Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpeptidyltransferase activity

GGTLC2 GGTLC1

2.25e-056252GO:0000048
GeneOntologyMolecularFunctionleukotriene-C(4) hydrolase

GGTLC2 GGTLC1

2.25e-056252GO:0002951
GeneOntologyMolecularFunctionleukotriene C4 gamma-glutamyl transferase activity

GGTLC2 GGTLC1

4.19e-058252GO:0103068
GeneOntologyMolecularFunctionglutathione hydrolase activity

GGTLC2 GGTLC1

5.39e-059252GO:0036374
GeneOntologyMolecularFunctionomega peptidase activity

GGTLC2 GGTLC1

1.79e-0416252GO:0008242
GeneOntologyMolecularFunctionthreonine-type peptidase activity

GGTLC2 GGTLC1

2.82e-0420252GO:0070003
GeneOntologyMolecularFunctiongrowth factor activity

BMP8B MSTN GDF6

1.28e-03173253GO:0008083
GeneOntologyMolecularFunctionproteoglycan binding

LRP1 PTPRF

1.85e-0351252GO:0043394
GeneOntologyMolecularFunctioncytokine activity

BMP8B MSTN GDF6

3.64e-03250253GO:0005125
GeneOntologyMolecularFunctionsulfur compound binding

LRP1 PTPRF MSTN

7.41e-03323253GO:1901681
GeneOntologyBiologicalProcesscysteine biosynthetic process

GGTLC2 GGTLC1

3.93e-058252GO:0019344
GeneOntologyBiologicalProcesspeptide modification

GGTLC2 GGTLC1

6.31e-0510252GO:0031179
GeneOntologyBiologicalProcessleukotriene D4 biosynthetic process

GGTLC2 GGTLC1

6.31e-0510252GO:1901750
GeneOntologyBiologicalProcessglutathione catabolic process

GGTLC2 GGTLC1

7.71e-0511252GO:0006751
GeneOntologyBiologicalProcessleukotriene D4 metabolic process

GGTLC2 GGTLC1

9.24e-0512252GO:1901748
GeneOntologyBiologicalProcesspeptide metabolic process

CPD GGTLC2 GGTLC1

1.40e-0484253GO:0006518
GeneOntologyBiologicalProcesscysteine metabolic process

GGTLC2 GGTLC1

1.67e-0416252GO:0006534
GeneOntologyBiologicalProcessglutathione biosynthetic process

GGTLC2 GGTLC1

2.64e-0420252GO:0006750
GeneOntologyBiologicalProcesssulfur amino acid biosynthetic process

GGTLC2 GGTLC1

2.92e-0421252GO:0000097
GeneOntologyBiologicalProcessleukotriene biosynthetic process

GGTLC2 GGTLC1

3.21e-0422252GO:0019370
GeneOntologyBiologicalProcessnonribosomal peptide biosynthetic process

GGTLC2 GGTLC1

3.21e-0422252GO:0019184
GeneOntologyBiologicalProcessserine family amino acid biosynthetic process

GGTLC2 GGTLC1

4.16e-0425252GO:0009070
MousePhenofailure of superovulation

TBPL2 GGTLC2 GGTLC1

2.72e-0618223MP:0031422
MousePhenooocyte degeneration

TBPL2 GGTLC2 GGTLC1

2.72e-0618223MP:0009093
MousePhenoanovulation

TBPL2 GGTLC2 GGTLC1

1.79e-0533223MP:0008869
MousePhenoabnormal circulating glutathione level

GGTLC2 GGTLC1

2.36e-055222MP:0030652
MousePhenoincreased circulating glutathione level

GGTLC2 GGTLC1

2.36e-055222MP:0030653
MousePhenoincreased glutathione level

GGTLC2 GGTLC1

2.36e-055222MP:0012606
MousePhenoglutathionuria

GGTLC2 GGTLC1

2.36e-055222MP:0013730
MousePhenodecreased tertiary ovarian follicle number

TBPL2 GGTLC2 GGTLC1

2.98e-0539223MP:0011129
MousePhenoabnormal ovarian folliculogenesis

TBPL2 GGTLC2 GGTLC1 ARID5B

3.35e-05120224MP:0001130
MousePhenodecreased circulating cysteine level

GGTLC2 GGTLC1

4.94e-057222MP:0030626
MousePhenoabnormal tertiary ovarian follicle number

TBPL2 GGTLC2 GGTLC1

5.25e-0547223MP:0011127
MousePhenoepididymis hypoplasia

GGTLC2 GGTLC1

6.58e-058222MP:0004932
MousePhenodecreased cysteine level

GGTLC2 GGTLC1

6.58e-058222MP:0030623
MousePhenonervous

GGTLC2 GGTLC1

8.46e-059222MP:0008912
MousePhenoabnormal tertiary ovarian follicle morphology

TBPL2 GGTLC2 GGTLC1

9.37e-0557223MP:0009363
MousePhenofailure of copulatory plug deposition

GGTLC2 GGTLC1

1.06e-0410222MP:0030983
MousePhenoseminal vesicle hypoplasia

GGTLC2 GGTLC1

1.06e-0410222MP:0005148
MousePhenoovary hypoplasia

GGTLC2 GGTLC1

1.06e-0410222MP:0005158
MousePhenoimpaired ovarian folliculogenesis

TBPL2 GGTLC2 GGTLC1

1.15e-0461223MP:0001129
MousePhenoabnormal circulating cysteine level

GGTLC2 GGTLC1

1.29e-0411222MP:0030624
MousePhenoabsent tertiary ovarian follicles

GGTLC2 GGTLC1

1.29e-0411222MP:0011130
MousePhenoabnormal superovulation

TBPL2 GGTLC2 GGTLC1

1.45e-0466223MP:0009648
MousePhenoabsent corpus luteum

GGTLC2 GGTLC1 ARID5B

1.45e-0466223MP:0001134
MousePhenoabnormal cysteine level

GGTLC2 GGTLC1

1.82e-0413222MP:0030621
MousePhenodecreased glutathione level

GGTLC2 GGTLC1

1.82e-0413222MP:0012604
MousePhenoabnormal glutathione level

GGTLC2 GGTLC1

1.82e-0413222MP:0012603
MousePhenopriapism

GGTLC2 GGTLC1

2.13e-0414222MP:0003415
MousePhenoabnormal ovarian follicle number

TBPL2 GGTLC2 GGTLC1 ARID5B

2.57e-04203224MP:0008871
MousePhenoabnormal copulatory plug deposition

GGTLC2 GGTLC1

2.80e-0416222MP:0030982
MousePhenodecreased spleen red pulp amount

GGTLC2 GGTLC1

2.80e-0416222MP:0008477
MousePhenoabnormal penile erection

GGTLC2 GGTLC1

3.56e-0418222MP:0001379
MousePhenofemale infertility

TBPL2 GGTLC2 GGTLC1 ARID5B NLRP5

3.69e-04410225MP:0001926
MousePhenosmall uterus

GGTLC2 GGTLC1 ARID5B

3.88e-0492223MP:0002637
MousePhenoabnormal copulation physiology

GGTLC2 GGTLC1

3.98e-0419222MP:0031627
MousePhenoincreased circulating growth hormone level

GGTLC2 GGTLC1

3.98e-0419222MP:0005123
MousePhenoabnormal sexual interaction

GGTLC2 GGTLC1 ARID5B

4.13e-0494223MP:0002566
MousePhenoabnormal ovulation

TBPL2 GGTLC2 GGTLC1

4.53e-0497223MP:0001928
MousePhenoabnormal ovarian follicle morphology

TBPL2 GGTLC2 GGTLC1 ARID5B

5.25e-04245224MP:0001131
MousePhenosmall vertebrae

GGTLC2 GGTLC1

5.36e-0422222MP:0004610
MousePhenoincreased growth hormone level

GGTLC2 GGTLC1

5.86e-0423222MP:0005137
MousePhenouterus hypoplasia

GGTLC2 GGTLC1

5.86e-0423222MP:0001121
MousePhenosmall seminiferous tubules

BMP8B GGTLC2 GGTLC1

6.04e-04107223MP:0001153
MousePhenoabnormal copulation behavior

GGTLC2 GGTLC1

6.39e-0424222MP:0009697
MousePhenoabnormal seminiferous tubule size

BMP8B GGTLC2 GGTLC1

6.72e-04111223MP:0006307
MousePhenoabnormal long bone hypertrophic chondrocyte zone

GGTLC2 GGTLC1 ARID5B

7.08e-04113223MP:0000165
MousePhenonuclear cataract

GGTLC2 GGTLC1

7.51e-0426222MP:0010254
MousePhenoabnormal corpus luteum morphology

GGTLC2 GGTLC1 ARID5B

7.64e-04116223MP:0002679
MousePhenoaminoaciduria

GGTLC2 GGTLC1

9.36e-0429222MP:0003311
MousePhenoshort femur

GGTLC2 MSTN GGTLC1

9.94e-04127223MP:0003109
MousePhenodecreased femur size

GGTLC2 MSTN GGTLC1

1.06e-03130223MP:0030825
MousePhenodecreased circulating follicle stimulating hormone level

GGTLC2 GGTLC1

1.29e-0334222MP:0002790
MousePhenoabnormal female germ cell morphology

TBPL2 GGTLC2 GGTLC1

1.61e-03150223MP:0006361
MousePhenodecreased circulating estradiol level

GGTLC2 GGTLC1

1.61e-0338222MP:0005181
MousePhenoabnormal cartilage morphology

GGTLC2 GGTLC1 GDF6 ARID5B

1.70e-03336224MP:0000163
MousePhenoinfertility

TBPL2 BMP8B IQCN GGTLC2 GGTLC1 ARID5B NLRP5

1.72e-031188227MP:0001924
MousePhenoabsent mature ovarian follicles

TBPL2 ARID5B

1.78e-0340222MP:0001132
MousePhenoabnormal limb bone morphology

GGTLC2 MSTN GGTLC1 GDF6 ARID5B

1.86e-03587225MP:0002115
MousePhenodecreased circulating estrogen level

GGTLC2 GGTLC1

1.87e-0341222MP:0003371
MousePhenoinduced hyperactivity

GGTLC2 GGTLC1

1.96e-0342222MP:0008911
MousePhenodecreased follicle stimulating hormone level

GGTLC2 GGTLC1

2.15e-0344222MP:0005130
MousePhenodecreased long bone epiphyseal plate size

GGTLC2 GGTLC1

2.15e-0344222MP:0006396
MousePhenoabsent estrous cycle

GGTLC2 GGTLC1

2.15e-0344222MP:0009009
MousePhenoabnormal uterus size

GGTLC2 GGTLC1 ARID5B

2.22e-03168223MP:0004902
MousePhenodecreased pro-B cell number

LYL1 ARID5B

2.35e-0346222MP:0008208
MousePhenoabnormal cartilage development

GGTLC2 GGTLC1 ARID5B

2.37e-03172223MP:0000164
MousePhenoabnormal long bone epiphyseal plate morphology

GGTLC2 GGTLC1 ARID5B

2.37e-03172223MP:0003055
MousePhenoabnormal seminiferous tubule morphology

BMP8B GGTLC2 GGTLC1 ARID5B

2.59e-03377224MP:0002216
MousePhenosmall ovary

TBPL2 GGTLC2 GGTLC1

2.62e-03178223MP:0001127
MousePhenodecreased thyroxine level

GGTLC2 GGTLC1

2.88e-0351222MP:0005471
MousePhenoabnormal epiphyseal plate morphology

GGTLC2 GGTLC1 ARID5B

2.92e-03185223MP:0006395
MousePhenoabnormal circulating estradiol level

GGTLC2 GGTLC1

2.99e-0352222MP:0005183
MousePhenoaciduria

GGTLC2 GGTLC1

3.34e-0355222MP:0010028
MousePhenodecreased length of long bones

GGTLC2 MSTN GGTLC1 ARID5B

3.48e-03409224MP:0004686
MousePhenoabnormal circulating estrogen level

GGTLC2 GGTLC1

3.58e-0357222MP:0003369
MousePhenodisproportionate dwarf

GGTLC2 GGTLC1

3.58e-0357222MP:0002427
MousePhenoabnormal growth hormone level

GGTLC2 GGTLC1

3.58e-0357222MP:0003968
MousePhenoabnormal urine amino acid level

GGTLC2 GGTLC1

3.83e-0359222MP:0011468
MousePhenoimmotile sperm

GGTLC2 GGTLC1

3.83e-0359222MP:0020869
MousePhenoabnormal social/conspecific interaction behavior

GGTLC2 PTPRF GGTLC1 ARID5B

3.86e-03421224MP:0002557
MousePhenodecreased circulating gonadotropin level

GGTLC2 GGTLC1

3.96e-0360222MP:0003363
MousePhenodecreased circulating testosterone level

GGTLC2 GGTLC1

3.96e-0360222MP:0002780
MousePhenodecreased circulating insulin-like growth factor I level

GGTLC2 GGTLC1

4.09e-0361222MP:0004701
MousePhenoabnormal limb morphology

LRP1 GGTLC2 MSTN GGTLC1 GDF6 ARID5B

4.18e-031028226MP:0002109
MousePhenoabnormal femur morphology

GGTLC2 MSTN GGTLC1

4.40e-03214223MP:0000559
MousePhenoabnormal hindlimb stylopod morphology

GGTLC2 MSTN GGTLC1

4.45e-03215223MP:0003856
MousePhenodiluted coat color

GGTLC2 GGTLC1

4.49e-0364222MP:0000371
MousePhenoabnormal thyroxine level

GGTLC2 GGTLC1

4.77e-0366222MP:0005469
MousePhenoabnormal ovary morphology

TBPL2 GGTLC2 GGTLC1 ARID5B

4.93e-03451224MP:0001126
MousePhenoabnormal long bone epiphyseal plate proliferative zone

GGTLC2 GGTLC1

5.06e-0368222MP:0003662
MousePhenoabnormal gametogenesis

TBPL2 BMP8B IQCN GGTLC2 GGTLC1 ARID5B

5.09e-031070226MP:0001929
MousePhenoabnormal ovary size

TBPL2 GGTLC2 GGTLC1

5.24e-03228223MP:0004853
DomainTGFb_propeptide

BMP8B MSTN GDF6

5.98e-0628243PF00688
DomainTGF-b_N

BMP8B MSTN GDF6

5.98e-0628243IPR001111
DomainTGF-beta-rel

BMP8B MSTN GDF6

9.02e-0632243IPR015615
DomainTGFb_CS

BMP8B MSTN GDF6

9.02e-0632243IPR017948
DomainTGFB

BMP8B MSTN GDF6

1.41e-0537243SM00204
DomainTGF_BETA_2

BMP8B MSTN GDF6

1.41e-0537243PS51362
DomainTGF_beta

BMP8B MSTN GDF6

1.41e-0537243PF00019
DomainTGF-b_C

BMP8B MSTN GDF6

1.41e-0537243IPR001839
DomainTGF_BETA_1

BMP8B MSTN GDF6

1.41e-0537243PS00250
DomainGGT_peptidase

GGTLC2 GGTLC1

3.31e-057242IPR000101
DomainG_glu_transpept

GGTLC2 GGTLC1

3.31e-057242PF01019
DomainG_GLU_TRANSPEPTIDASE

GGTLC2 GGTLC1

3.31e-057242PS00462
Domain-

BMP8B MSTN GDF6

8.46e-05672432.10.90.10
DomainCystine-knot_cytokine

BMP8B MSTN GDF6

8.46e-0567243IPR029034
DomainNtn_hydrolases_N

GGTLC2 GGTLC1

8.15e-0433242IPR029055
DomainEGF_3

LRP1 FAT2 ADAM23

3.27e-03235243PS50026
DomainEGF

LRP1 FAT2 ADAM23

3.27e-03235243SM00181
DomainEGF-like_dom

LRP1 FAT2 ADAM23

3.85e-03249243IPR000742
DomainEGF_1

LRP1 FAT2 ADAM23

4.12e-03255243PS00022
DomainEGF-like_CS

LRP1 FAT2 ADAM23

4.39e-03261243IPR013032
DomainEGF_2

LRP1 FAT2 ADAM23

4.59e-03265243PS01186
DomainEGF_CA

LRP1 FAT2

1.06e-02122242SM00179
DomainEGF-like_Ca-bd_dom

LRP1 FAT2

1.10e-02124242IPR001881
DomainEGF

LRP1 FAT2

1.13e-02126242PF00008
PathwayKEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY_BMP_ANTAGONIST

BMP8B GDF6

1.79e-0415192M47824
PathwayREACTOME_GLUTATHIONE_SYNTHESIS_AND_RECYCLING

GGTLC2 GGTLC1

2.04e-0416192MM14680
PathwayKEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY

BMP8B GDF6

3.22e-0420192M47843
PathwayWP_EICOSANOID_SYNTHESIS

GGTLC2 GGTLC1

3.91e-0422192MM15961
PathwayWP_OXYLIPINS_PATHWAYS

GGTLC2 GGTLC1

4.67e-0424192MM17249
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

GGTLC2 GGTLC1

5.07e-0425192MM14858
PathwayREACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION

GGTLC2 GGTLC1

5.49e-0426192MM15190
PathwayWP_GLUTATHIONE_METABOLISM

GGTLC2 GGTLC1

5.92e-0427192MM15908
PathwayWP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX

GGTLC2 GGTLC1

8.86e-0433192MM15963
PathwayWP_GLUTATHIONE_AND_ONECARBON_METABOLISM

GGTLC2 GGTLC1

9.97e-0435192MM15815
PathwayREACTOME_GLUTATHIONE_CONJUGATION

GGTLC2 GGTLC1

1.18e-0338192MM14600
PathwayREACTOME_PARACETAMOL_ADME

GGTLC2 GGTLC1

1.24e-0339192MM15695
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

GGTLC2 GGTLC1

3.00e-0361192MM14861
Pubmed

Human lung expresses unique gamma-glutamyl transpeptidase transcripts.

GGTLC2 GGTLC1

1.74e-0632727689219
Pubmed

Lung lining fluid glutathione attenuates IL-13-induced asthma.

GGTLC2 GGTLC1

5.80e-06527218063838
Pubmed

Gamma-glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses.

GGTLC2 GGTLC1

5.80e-06527210940879
Pubmed

Accumulation of DNA damage in the organs of mice deficient in gamma-glutamyltranspeptidase.

GGTLC2 GGTLC1

5.80e-06527210751614
Pubmed

Liver-Specific Overexpression of Gamma-Glutamyltransferase Ameliorates Insulin Sensitivity of Male C57BL/6 Mice.

GGTLC2 GGTLC1

5.80e-06527228660214
Pubmed

Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice.

GGTLC2 GGTLC1

5.80e-06527212468440
Pubmed

N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.

GGTLC2 GGTLC1

5.80e-06527226977590
Pubmed

Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia.

GGTLC2 GGTLC1

5.80e-06527212225953
Pubmed

Identification of a sixth promoter that directs the transcription of gamma-glutamyl transpeptidase type III RNA in mouse.

GGTLC2 GGTLC1

5.80e-0652727775425
Pubmed

Cataract development in gamma-glutamyl transpeptidase-deficient mice.

GGTLC2 GGTLC1

5.80e-06527211095909
Pubmed

Expression of gamma-glutamyl transpeptidase in midgestation mouse yolk sac and mouse visceral yolk sac carcinoma cells.

GGTLC2 GGTLC1

5.80e-0652727641802
Pubmed

Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species.

GGTLC2 GGTLC1

5.80e-06527210392451
Pubmed

Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.

GGTLC2 GGTLC1

5.80e-06527223615310
Pubmed

Type VI RNA is the major gamma-glutamyl transpeptidase RNA in the mouse small intestine.

GGTLC2 GGTLC1

5.80e-0652727523374
Pubmed

Cloning of cDNA and genomic structure of the mouse gamma-glutamyl transpeptidase-encoding gene.

GGTLC2 GGTLC1

5.80e-0652728566783
Pubmed

Therapeutic Effect of GGsTop, Selective Gamma-glutamyl Transpeptidase Inhibitor, on a Mouse Model of 5-Fluorouracil-induced Oral Mucositis.

GGTLC2 GGTLC1

5.80e-06527230591459
Pubmed

Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney.

GGTLC2 GGTLC1

5.80e-0652722891746
Pubmed

Cardio-reno-hepatic interactions in acute heart failure: the role of γ-glutamyl transferase.

GGTLC2 GGTLC1

5.80e-06527224698228
Pubmed

Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress.

GGTLC2 GGTLC1

5.80e-06527219850887
Pubmed

Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility.

GGTLC2 GGTLC1

5.80e-0652729139708
Pubmed

Analysis of site-specific glycosylation of renal and hepatic γ-glutamyl transpeptidase from normal human tissue.

GGTLC2 GGTLC1

5.80e-06527220622017
Pubmed

The mouse skin carcinogenesis model.

GGTLC2 GGTLC1

5.80e-0652729627710
Pubmed

Accelerated methylmercury elimination in gamma-glutamyl transpeptidase-deficient mice.

GGTLC2 GGTLC1

5.80e-0652729546365
Pubmed

Gamma-glutamyl transpeptidase and its role in melanogenesis: redox reactions and regulation of tyrosinase.

GGTLC2 GGTLC1

5.80e-06527212453183
Pubmed

In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knockout mice.

GGTLC2 GGTLC1

5.80e-06527211795900
Pubmed

gamma-Glutamyl transpeptidase. What does the organization and expression of a multipromoter gene tell us about its functions?

GGTLC2 GGTLC1

5.80e-0652727485380
Pubmed

Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma.

GGTLC2 GGTLC1

5.80e-06527225132819
Pubmed

Characterization of the dwg mutations: dwg and dwg(Bayer) are new mutant alleles of the Ggt1 gene.

GGTLC2 GGTLC1

5.80e-06527219760322
Pubmed

gamma-glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function, and cellular function.

GGTLC2 GGTLC1

5.80e-06527211003618
Pubmed

gamma-Glutamyl transferase (GGT) deficiency in the GGTenu1 mouse results from a single point mutation that leads to a stop codon in the first coding exon of GGT mRNA.

GGTLC2 GGTLC1

5.80e-06527210474818
Pubmed

Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice.

GGTLC2 GGTLC1

5.80e-06527212810527
Pubmed

Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice.

GGTLC2 GGTLC1

5.80e-0652728755578
Pubmed

Reproductive defects in gamma-glutamyl transpeptidase-deficient mice.

GGTLC2 GGTLC1

5.80e-06527211089562
Pubmed

Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosis.

GGTLC2 GGTLC1

8.69e-06627217363454
Pubmed

Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse.

GGTLC2 GGTLC1

8.69e-0662728101000
Pubmed

Four distinct membrane-bound dipeptidase RNAs are differentially expressed and show discordant regulation with gamma-glutamyl transpeptidase.

GGTLC2 GGTLC1

8.69e-0662728663190
Pubmed

Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes.

GGTLC2 GGTLC1

8.69e-0662728104871
Pubmed

Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response.

GGTLC2 GGTLC1

8.69e-06627211463821
Pubmed

Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.

GGTLC2 GGTLC1

8.69e-06627212163373
Pubmed

Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor.

GGTLC2 GGTLC1

8.69e-06627214634009
Pubmed

Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice.

GGTLC2 GGTLC1

8.69e-06627222242126
Pubmed

Effect of atorvastatin on the expression of gamma-glutamyl transferase in aortic atherosclerotic plaques of apolipoprotein E-knockout mice.

GGTLC2 GGTLC1

8.69e-06627225326709
Pubmed

TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.

BMP8B MSTN GDF6

1.07e-055527315342483
Pubmed

γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.

GGTLC2 GGTLC1

1.22e-05727227775020
Pubmed

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.

GGTLC2 GGTLC1

1.22e-05727232284594
Pubmed

Defective epidermal growth factor gene expression in mice with polycystic kidney disease.

GGTLC2 GGTLC1

1.22e-0572721968405
Pubmed

m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis.

GGTLC2 GGTLC1

1.22e-05727236685533
Pubmed

Renalase regulates renal dopamine and phosphate metabolism.

GGTLC2 GGTLC1

2.60e-051027223863468
Pubmed

Alternative splice variants encoding unstable protein domains exist in the human brain.

FAT2 PTPRF

4.50e-051327215491607
Pubmed

The human gamma-glutamyltransferase gene family.

GGTLC2 GGTLC1

5.25e-051427218357469
Pubmed

A large-scale candidate gene association study of age at menarche and age at natural menopause.

BMP8B MSTN GDF6 NLRP5

5.82e-0527527420734064
Pubmed

Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome.

GGTLC2 GGTLC1

8.81e-051827217097888
Pubmed

Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine.

GGTLC2 GGTLC1

2.01e-042727218478268
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

SORCS2 ZNF687 HACE1

2.26e-0415327310718198
Pubmed

Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells.

GGTLC2 GGTLC1

2.33e-042927222424930
Pubmed

Functional analysis of secreted and transmembrane proteins critical to mouse development.

PTPRF ADAM23

2.66e-043127211431694
Pubmed

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.

GGTLC2 GGTLC1

4.01e-043827227820600
Pubmed

Mouse models of ocular diseases.

GGTLC2 GGTLC1

5.38e-044427216332269
Pubmed

A comprehensive analysis of 22q11 gene expression in the developing and adult brain.

GGTLC2 GGTLC1

5.63e-044527214614146
GeneFamilyCD molecules|Gamma-glutamyltransferases

GGTLC2 GGTLC1

7.25e-0513182564
GeneFamilyFibronectin type III domain containing

FNDC8 PTPRF

1.09e-02160182555
GeneFamilyAnkyrin repeat domain containing

NUDT12 HACE1

2.37e-02242182403
CoexpressionGAVIN_FOXP3_TARGETS_CLUSTER_P3

SORCS2 GGTLC2 ARMCX4 LYL1 GGTLC1

8.48e-07173275MM725
CoexpressionGSE12366_NAIVE_VS_MEMORY_BCELL_UP

NUDT12 LYL1 MSTN ARHGEF5

4.56e-05195274M3178
CoexpressionGSE7852_TREG_VS_TCONV_UP

CPD ARMCX4 ARID5B NLRP5

5.03e-05200274M5751
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)-|367C / Donor, Lineage, Cell class and subclass (all cells)

GGTLC2 PTPRF ARHGEF5 GGTLC1

3.54e-06174274edf839d79ac58921f4e788f3b2cb2ae0d6af4b9e
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)|367C / Donor, Lineage, Cell class and subclass (all cells)

GGTLC2 PTPRF ARHGEF5 GGTLC1

3.54e-0617427465539f69100db0b7d90b1b39ee15ab8281f86461
ToppCelldroplet-Kidney-nan-3m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBPL2 SORCS2 GPR37L1 ADAM23

4.14e-061812740b1e7335648823b1d83bdfa878ccd44efe7bba9a
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

NUDT12 LYL1 ZNF653

1.04e-04152273b8aa62e3cf2b4c252db4bccfa75d881c4fa0a788
ToppCellwk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

LRP1 MSTN ZNF653

1.35e-0416627365dafed953b01a9830b54309af75c7a561e88336
ToppCelldroplet-Heart-4Chambers-21m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS2 GPR37L1 ADAM23

1.66e-041782733e8aacb27ed1a3c3978e21dddddd0828f8000692
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS2 GPR37L1 ADAM23

1.72e-04180273dad458398683ff80a6e207bdc08e257d1bb757d6
ToppCellP28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SORCS2 GPR37L1 ADAM23

1.72e-041802731e819c5c87704ec6535dfeaae56561895e239d07
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS2 GPR37L1 ADAM23

1.72e-04180273d9c9399df3e2d9f23dbbfffb6cbe8404bf01e2b7
ToppCellCOPD-Epithelial-ATI|World / Disease state, Lineage and Cell class

GGTLC2 PTPRF GGTLC1

1.77e-04182273e95d946a43b1579af199900bb0e3eacbb9d65300
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS2 GPR37L1 ADAM23

1.77e-0418227382ca6d5ed48b4c487ce00b9309255abb8f20b61d
ToppCelldroplet-Limb_Muscle-nan-21m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR37L1 ADAM23 GDF6

1.77e-04182273a512863304fad80acaab60a8c6107eb7c9cbac99
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS2 GPR37L1 ADAM23

1.77e-04182273812ff2a50a510b18d865e89465dba1754a08ef61
ToppCelldroplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR37L1 PTPRF ADAM23

1.77e-041822736fdaf3c8c3952a8f14dd7288e523ed58eb1d3517
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBPL2 GPR37L1 ADAM23

1.77e-04182273e3248d108b51c49ca2c978636e13017e23b53860
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS2 GPR37L1 ADAM23

1.80e-041832738330c39184ce076e1f95fd3725b68af551d89db0
ToppCellAT1-AT2_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

IQCN PTPRF GGTLC1

1.80e-041832736821dca076318115d360ff426eb1218cfe104063
ToppCelldroplet-Limb_Muscle-nan-18m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS2 GPR37L1 ADAM23

1.83e-04184273a7399a72f065d68800e3e0b2031d9894e0cc0ba4
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS2 GPR37L1 ADAM23

1.86e-04185273ca69499ba8c39b7ed6717d05685d6f70066a77bd
ToppCell10x5'-GI_large-bowel-Lymphocytic_B-Naive_B_cells|GI_large-bowel / Manually curated celltypes from each tissue

NUDT12 LYL1 LINC02693

1.86e-041852731c99373c123b5e0de40b47d9d885974a747b9839
ToppCellControl-Epithelial-ATI|World / Disease state, Lineage and Cell class

GGTLC2 PTPRF GGTLC1

1.86e-041852730563d5042bb96ecce8446fbf26d05ef7a45e23c5
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS2 LRP1 GPR37L1

1.86e-04185273785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS2 LRP1 GPR37L1

1.86e-0418527397a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCellCOPD-Epithelial-ATI|COPD / Disease state, Lineage and Cell class

GGTLC2 PTPRF GGTLC1

1.89e-04186273df0977f6f48a2d4e11b59971f098b01204242f0f
ToppCellControl-Epithelial-ATI|Control / Disease state, Lineage and Cell class

GGTLC2 PTPRF GGTLC1

1.92e-04187273fdd1c57b61ca9392ac27661a82729f37593df63c
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR37L1 PTPRF ADAM23

1.95e-041882733b8b9161f0fdcbde302ce5b4c0bc874628211109
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR37L1 PTPRF ADAM23

1.95e-04188273c2101ded71fb16b8ddbc1f883911b1ed2a533ffc
ToppCelldroplet-Heart-nan-18m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORCS2 GPR37L1 PTPRF

1.98e-041892730493f7b79127c207fd7ade778ef4810500495d7e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SORCS2 PTPRF ADAM23

2.08e-041922739e031bf93eb8757fdd0cc22f01b44e48f85532d5
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SORCS2 PTPRF ADAM23

2.08e-041922733d777d07878269b87ec7e1f06489cae7c989d633
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SORCS2 PTPRF ADAM23

2.11e-04193273371f4c98a599923fbe8382530b3eab05d873665a
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

SORCS2 ADAM23 GDF6

2.11e-04193273194e7fa00a50cc4e026987b715323d125d79594e
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SORCS2 PTPRF ADAM23

2.14e-04194273158dc393639e69aecfb014f6106797214ea05fe5
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT2 PTPRF ARHGEF5

2.17e-0419527324d226f89dd337c22728688e4b40ca082a0e1fe1
ToppCell356C-Epithelial_cells-Epithelial-I_(AT1)-|356C / Donor, Lineage, Cell class and subclass (all cells)

GGTLC2 PTPRF GGTLC1

2.17e-04195273b65511770ed67f7447847e2187555b362988af45
ToppCell356C-Epithelial_cells-Epithelial-I_(AT1)|356C / Donor, Lineage, Cell class and subclass (all cells)

GGTLC2 PTPRF GGTLC1

2.17e-0419527307a3ef6b0f1201fe2bcb9ea426b8f7a69beb4904
ToppCell(7)_Epithelial-I_(AT1)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

GGTLC2 PTPRF GGTLC1

2.20e-04196273150554fa06868d29b0608189862eef6505ba757f
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

LRP1 MSTN ARID5B

2.24e-04197273fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT2 ARHGEF5 ARID5B

2.27e-04198273fc00cb25cdc6c31b7f9d397bc9f9a8f4e9708003
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LRP1 GPR37L1 GDF6

2.31e-0419927319a97e27a4758e794ce7246d295e112b47931a48
ToppCellSigmoid-T_cell-Tfh|T_cell / Region, Cell class and subclass

ADAM23 ZNF653 ARID5B

2.34e-04200273dd7dcf25520f065bf0d33d589f3c176f63875dc9
Diseaseaflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)

GGTLC2 GGTLC1

1.44e-057252DOID:5022 (biomarker_via_orthology)
Diseasealcohol dependence (biomarker_via_orthology)

GGTLC2 GGTLC1

1.92e-058252DOID:0050741 (biomarker_via_orthology)
Disease1,3,7-trimethylurate measurement

PTPRF ARID5B

7.19e-0515252EFO_0021172
Diseasediabetes mellitus (implicated_via_orthology)

LRP1 BMP8B

2.21e-0426252DOID:9351 (implicated_via_orthology)
DiseaseHeadache

TBPL2 LRP1

1.35e-0364252HP_0002315
DiseaseAbdominal Aortic Aneurysm

LRP1 NUDT12

1.52e-0368252EFO_0004214
Diseaseintelligence, self reported educational attainment

PTPRF LYL1

4.41e-03117252EFO_0004337, EFO_0004784
Diseasecannabis dependence

PTPRF ARID5B

5.82e-03135252EFO_0007191
Diseasesevere acute respiratory syndrome, COVID-19

TBPL2 SORCS2 ADAM23

6.20e-03447253EFO_0000694, MONDO_0100096
Diseasestroke

FAT2 PTPRF

6.59e-03144252EFO_0000712

Protein segments in the cluster

PeptideGeneStartEntry
GTPCGPSMMCLDRKC

ADAM23

711

O75077
SMDDPSPCGTSEMCP

ARHGEF5

561

Q12774
CKTGPGMDMKTCTQP

ARMCX4

536

Q5H9R4
SIMKSLPQVCPGPAM

IQCN

436

Q9H0B3
SKMMPECQCPPHMTG

LRP1

4391

Q07954
LPPSMLLSVQKCCMP

LINC02693

201

A8MQB3
AMPMVPCQGPTCQGQ

FAT2

3721

Q9NYQ8
PGKQPLSSMCPTIMV

GGTLC1

101

Q9BX51
MCCSCQMPPGMTSPR

HACE1

461

Q8IYU2
MPSCSCALMAPCGPA

MIR1-1HG

1

Q9H1L0
PGKQPLSSMCPTIMV

GGTLC2

101

Q14390
PKGMMKLCSAFACPT

NLRP5

1136

P59047
PAPTMGTLDSCIMKP

GPR37L1

276

O60883
PSMHMGQPSCPNKSD

CPD

1131

O75976
MCPPQAQAEVGPTMT

LYL1

1

P12980
MCGNNMSTPLPAIVP

LYPLA1

1

O75608
LMMPDAVPKACCAPT

BMP8B

356

P34820
PSAPPQKVMCVSMGS

PTPRF

606

P10586
ALGPCPCPSKSQMAT

FNDC8

136

Q8TC99
LMNSMDPGSTPPSCC

GDF6

406

Q6KF10
AGPCCTPTKMSPINM

MSTN

336

O14793
RPPSMDMNGKPTNCK

SORCS2

481

Q96PQ0
ACQPWPMPSSLMIGC

NUDT12

386

Q9BQG2
HPKACRVSPMTMSGP

ARID5B

951

Q14865
ASCPMPGMVPGSQVI

ZNF653

306

Q96CK0
GATSNVCPTCPMMLP

ZNF687

701

Q8N1G0
MTPMTPISECCGIVP

TBPL2

186

Q6SJ96