Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	DOCK3 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D GMIP TBC1D3C TBC1D3B OPHN1 RASA4 RASA4B TBC1D3I TBC1D3G TBC1D3K TBC1D3F AGAP3	1.60e-13	279	108	17	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK3 DENND2A TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 RAPGEF1 GMIP TBC1D3C TBC1D3B OPHN1 RASA4 RASA4B TBC1D3I TBC1D3G TBC1D3K TBC1D3F AGAP3	3.17e-12	507	108	20	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK3 DENND2A TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 RAPGEF1 GMIP TBC1D3C TBC1D3B OPHN1 RASA4 RASA4B TBC1D3I TBC1D3G TBC1D3K TBC1D3F AGAP3	3.17e-12	507	108	20	GO:0030695
GeneOntologyMolecularFunction	enzyme activator activity	DOCK3 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D GMIP TBC1D3C TBC1D3B OPHN1 GPR158 RASA4 RASA4B TBC1D3I TBC1D3G TBC1D3K TBC1D3F AGAP3	1.39e-08	656	108	18	GO:0008047
GeneOntologyMolecularFunction	molecular function activator activity	DOCK3 TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D FBRS GMIP TBC1D3C TBC1D3B OPHN1 GPR158 RASA4 FGF2 RASA4B C1QTNF12 TBC1D3I TBC1D3G TBC1D3K BMP15 TBC1D3F AGAP3	6.00e-07	1233	108	22	GO:0140677
GeneOntologyMolecularFunction	enzyme regulator activity	DOCK3 DENND2A TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 RAPGEF1 GMIP ANKLE2 TBC1D3C TBC1D3B OPHN1 GPR158 RASA4 RASA4B TBC1D3I TBC1D3G TBC1D3K TBC1D3F AGAP3	5.96e-06	1418	108	22	GO:0030234
GeneOntologyBiologicalProcess	activation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 RAPGEF1 GMIP TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F AGAP3	1.30e-17	109	107	15	GO:0090630
GeneOntologyBiologicalProcess	regulation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 RAPGEF1 GMIP TBC1D3C TBC1D3B RASIP1 RASA4 HRAS RASA4B TBC1D3I TBC1D3G TBC1D3K TBC1D3F AGAP3	8.99e-15	335	107	19	GO:0043087
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 RAPGEF1 GMIP TBC1D3C TBC1D3B HRAS TBC1D3I TBC1D3G TBC1D3K TBC1D3F AGAP3	1.50e-13	244	107	16	GO:0043547
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 RAPGEF1 GMIP TBC1D3C TBC1D3B HRAS TBC1D3I TBC1D3G TBC1D3K TBC1D3F AGAP3	6.21e-09	499	107	16	GO:0051345
GeneOntologyBiologicalProcess	regulation of hydrolase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 RAPGEF1 GMIP TBC1D3C TBC1D3B RASIP1 RASA4 HRAS RASA4B TBC1D3I TBC1D3G TBC1D3K TBC1D3F AGAP3	1.17e-07	878	107	19	GO:0051336
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	DOCK3 OGT ARHGEF5 RAPGEF1 GMIP OPHN1 RASIP1 RASA4 HRAS RASA4B	9.25e-06	333	107	10	GO:0051056
GeneOntologyBiologicalProcess	positive regulation of catalytic activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 RAPGEF1 GMIP TBC1D3C TBC1D3B HRAS FGF2 TBC1D3I TBC1D3G TBC1D3K TBC1D3F AGAP3	2.12e-05	1028	107	17	GO:0043085
GeneOntologyBiologicalProcess	small GTPase-mediated signal transduction	DOCK3 OGT ARHGEF5 RAPGEF1 GMIP OPHN1 RASIP1 RASA4 HRAS FGF2 RASA4B	1.11e-04	538	107	11	GO:0007264
Domain	TBC	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.26e-13	49	104	10	SM00164
Domain	RabGAP-TBC	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	2.94e-13	53	104	10	PF00566
Domain	TBC_RABGAP	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	4.37e-13	55	104	10	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	4.37e-13	55	104	10	IPR000195
Domain	-	RASA4 RASA4B	9.18e-05	3	104	2	4.10.1130.10
Domain	Chromo_domain	CHD3 CHD6 CBX2	3.12e-04	24	104	3	IPR023780
Domain	Chromo	CHD3 CHD6 CBX2	3.97e-04	26	104	3	PF00385
Domain	CHROMO_1	CHD3 CHD6 CBX2	4.97e-04	28	104	3	PS00598
Domain	CHROMO_2	CHD3 CHD6 CBX2	4.97e-04	28	104	3	PS50013
Domain	Chromodomain-like	CHD3 CHD6 CBX2	7.40e-04	32	104	3	IPR016197
Domain	Chromo/shadow_dom	CHD3 CHD6 CBX2	8.10e-04	33	104	3	IPR000953
Domain	CHROMO	CHD3 CHD6 CBX2	8.10e-04	33	104	3	SM00298
Domain	BTK	RASA4 RASA4B	1.08e-03	9	104	2	SM00107
Domain	Znf_Btk_motif	RASA4 RASA4B	1.08e-03	9	104	2	IPR001562
Domain	BTK	RASA4 RASA4B	1.08e-03	9	104	2	PF00779
Domain	ZF_BTK	RASA4 RASA4B	1.08e-03	9	104	2	PS51113
Pathway	WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K	1.92e-09	99	73	9	M46448
Pubmed	TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.53e-28	11	108	11	16863688
Pubmed	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.	TBC1D3E TBC1D3 TBC1D3H TBC1D3D CEP295NL TBC1D3B TBC1D3G TBC1D3F	8.45e-11	74	108	8	16625196
Pubmed	PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.	TBC1D3 TBC1D3D TBC1D3F	1.16e-07	4	108	3	12359748
Pubmed	Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.	TBC1D3 TBC1D3D TBC1D3F	1.16e-07	4	108	3	8406013
Pubmed	The Tre2 (USP6) oncogene is a hominoid-specific gene.	TBC1D3 TBC1D3D TBC1D3C	2.90e-07	5	108	3	12604796
Pubmed	Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.	TBC1D3 TBC1D3D TBC1D3F	2.90e-07	5	108	3	8471161
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	ARHGEF5 RASA4 RASA4B	1.61e-06	8	108	3	10810084
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	OGT RPH3AL UVSSA MINK1 KAT6A LARP1 CHD3 SHISA9 HIVEP3 NCOR2 GPR158 ZFHX2 CHD6 ATP2B1 TMCC1 RAI1 AGAP3	3.42e-06	1489	108	17	28611215
Pubmed	HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway.	SHC3 HRAS FGF2	6.28e-06	12	108	3	16436505
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ZNF777 ILF3 BAZ2B LARP1 CHD3 HNRNPUL1 PRAM1 NCOR2 RBM15B PDCD11 RAI1 NOL8 CBX2	8.55e-06	954	108	13	36373674
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOCK3 TEAD2 KAT6A FBRS MAML1 RAPGEF1 HIVEP3 NCOR2 MEGF8 PDCD11 CAMSAP1 RAI1 CBX2 AGAP3	8.56e-06	1105	108	14	35748872
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	9.55e-06	2	108	2	11448776
Pubmed	CHD6 is a DNA-dependent ATPase and localizes at nuclear sites of mRNA synthesis.	CHD3 CHD6	9.55e-06	2	108	2	17027977
Pubmed	The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development.	SHC3 RAI1	9.55e-06	2	108	2	23345394
Pubmed	Polycomb repressive complex 2 is necessary for the normal site-specific O-GlcNAc distribution in mouse embryonic stem cells.	OGT CBX2	9.55e-06	2	108	2	21606357
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	9.55e-06	2	108	2	16041389
Pubmed	CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.	RAPGEF1 HRAS	9.55e-06	2	108	2	10514505
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	KAT6A LARP1 CHD3 ANKLE2 FGF2 MTCL1 CAMSAP1 GOLGA3	9.75e-06	332	108	8	37433992
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	BAZ2B KAT6A CHD3 CHD6 CBX2 DNMT3A	1.01e-05	157	108	6	30186101
Pubmed	Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.	LARP1 RASIP1 SUPT5H	1.03e-05	14	108	3	22354037
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CDK17 ARHGEF5 MINK1 LARP1 HNRNPUL1 MAST4 MEGF8 MTCL1 CAMSAP1 ATP2B1 TMCC1 AGAP3	1.56e-05	861	108	12	36931259
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	ILF3 ZNF366 PRR30 RUSC1 CHD3 RBM15B VAMP4 CBX2	1.89e-05	364	108	8	31391242
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	OGT BAZ2B RADX ARHGEF5 KAT6A CHD3 CHD6 RAI1 CBX2 DNMT3A	2.07e-05	608	108	10	36089195
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	2.86e-05	3	108	2	25637021
Pubmed	Analysis of Gene Expression Patterns of Epigenetic Enzymes Dnmt3a, Tet1 and Ogt in Murine Chondrogenic Models.	OGT DNMT3A	2.86e-05	3	108	2	34685658
Pubmed	Diversity of human copy number variation and multicopy genes.	TBC1D3E TBC1D3G	2.86e-05	3	108	2	21030649
Pubmed	DC-SCRIPT affects mammary organoids branching morphogenesis by modulating the FGFR1-pERK signaling axis.	ZNF366 FGF2	2.86e-05	3	108	2	32422143
Pubmed	Identification of endothelial cell genes by combined database mining and microarray analysis.	ABI3BP RASIP1	2.86e-05	3	108	2	12644598
Pubmed	Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.	HRAS FGF2	2.86e-05	3	108	2	19319189
Pubmed	The Ras/MAPK pathway is required for generation of iNKT cells.	EGR2 HRAS	2.86e-05	3	108	2	21572967
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DENND2A UVSSA MAML1 LARP1 ANKLE2 MAST4 PDCD11 PADI2 RAI1	4.20e-05	529	108	9	14621295
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ILF3 OGT MINK1 HCN3 NCOR2 GPR158 HRAS MTCL1 FRMPD3 CAMSAP1 GOLGA3 RAI1	4.63e-05	963	108	12	28671696
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	OGT FBRS RUSC1 CHD3 NCOR2 CHD6 CAMSAP1 GOLGA3	5.03e-05	418	108	8	34709266
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	5.71e-05	4	108	2	21460216
Pubmed	Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export.	NCOR2 RBM15B	5.71e-05	4	108	2	16129689
Pubmed	Chromosomal mapping of beta-globin and albino loci in the domestic cat. A conserved mammalian chromosome group.	ACP2 HRAS	5.71e-05	4	108	2	3559163
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	5.71e-05	4	108	2	16234249
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	TEAD2 MAML1 HNRNPUL1 SOWAHC NCOR2 TFCP2L1 ZNF41 SUPT5H UTF1 RAI1 DNMT3A	9.20e-05	877	108	11	20211142
Pubmed	RAS interaction with PI3K p110α is required for tumor-induced angiogenesis.	HRAS FGF2	9.50e-05	5	108	2	25003191
Pubmed	Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).	RAPGEF1 HRAS	9.50e-05	5	108	2	9266971
Pubmed	Functional proteomics mapping of a human signaling pathway.	CHD3 HNRNPUL1 ANKLE2 NCOR2 MAST4 ZNF41 SUPT5H CHD6 CAMSAP1	9.78e-05	591	108	9	15231748
Pubmed	The DNA sequence and comparative analysis of human chromosome 10.	CPEB3 UBTD1 FBH1 EGR2 GPR158 UTF1 ACSL5	1.05e-04	345	108	7	15164054
Pubmed	O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation.	OGT VAMP4	1.42e-04	6	108	2	25419848
Pubmed	Genome-wide association study of antibody response to smallpox vaccine.	ANKLE2 GPR158 GOLGA3	1.62e-04	34	108	3	22542470
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	FBRS MAML1 TTBK2 NCOR2 MEGF8 CHD6 MTCL1 ATP2B1 RAI1	1.74e-04	638	108	9	31182584
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ILF3 OGT BAZ2B CHD3 HNRNPUL1 NCOR2 MYPOP SUPT5H RBM15B PDCD11 CHD6 RAI1 NOL8	1.92e-04	1294	108	13	30804502
Pubmed	Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.	HCN3 DNMT3A	1.99e-04	7	108	2	27956497
Pubmed	MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.	CHD3 NCOR2	1.99e-04	7	108	2	15454082
Pubmed	The structural basis of the activation of Ras by Sos.	SHC3 HRAS	1.99e-04	7	108	2	9690470
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	BAZ2B LARP1 CHD3 SUPT5H CHD6 CBX2	2.58e-04	282	108	6	23667531
Pubmed	C3G regulates the size of the cerebral cortex neural precursor population.	RAPGEF1 FGF2	2.64e-04	8	108	2	16858399
Pubmed	Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.	PRAM1 NCOR2	2.64e-04	8	108	2	11430826
Pubmed	Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.	ILF3 LARP1 HNRNPUL1	2.65e-04	40	108	3	23825951
Pubmed	MicroRNA and target gene expression based clustering of oral cancer, precancer and normal tissues.	CPEB3 DNMT3A	3.39e-04	9	108	2	27515006
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	KAT6A TFCP2L1 HRAS FGF2 UTF1 BMP15 DNMT3A	3.69e-04	424	108	7	21731673
Pubmed	Regulation of GATA-3 expression during CD4 lineage differentiation.	EGR2 HRAS	4.23e-04	10	108	2	21357543
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	ILF3 CHD3 PDCD11 ATP2B1 GOLGA3	4.32e-04	202	108	5	24639526
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	ILF3 NCOR2 PDCD11 CBX2	4.82e-04	116	108	4	21282530
Pubmed	Human transcription factor protein interaction networks.	TEAD2 OGT DET1 RADX FBRS MAML1 LARP1 CHD3 HNRNPUL1 NCOR2 PDCD11 CHD6 CBX2	4.95e-04	1429	108	13	35140242
Pubmed	The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.	CHD3 NCOR2	5.16e-04	11	108	2	23658227
Pubmed	Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.	RASIP1 HRAS	5.16e-04	11	108	2	15031288
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ILF3 ABI3BP LARP1 CHD3 ANKLE2 C9orf43 MYPOP TMEM184C CC2D2A CHD6 TOP1MT ATP2B1 RAI1	5.39e-04	1442	108	13	35575683
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	TEAD2 FBRS MAML1 NCOR2 MEIOC PDCD11 RAI1	5.76e-04	457	108	7	32344865
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	CDK17 ILF3 CPEB3 LARP1 HNRNPUL1 GPR158 ACSL5	6.14e-04	462	108	7	31138677
Pubmed	A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool.	EGR2 HRAS	6.18e-04	12	108	2	10704452
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ILF3 OGT BAZ2B MAML1 LARP1 CHD3 HNRNPUL1 ZC3H10 PRAM1 NCOR2 RAI1	6.49e-04	1103	108	11	34189442
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	BAZ2B MAML1 SUPT5H PDCD11 NOL8	6.62e-04	222	108	5	37071664
Pubmed	O-GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/β-catenin signalling.	OGT LARP1	7.29e-04	13	108	2	37070251
Pubmed	Interaction network of human early embryonic transcription factors.	OGT FBRS MAML1 NCOR2 EGR2 RAI1	8.17e-04	351	108	6	38297188
Pubmed	Sour Sensing from the Tongue to the Brain.	HCN3 EGR2	8.48e-04	14	108	2	31543264
Pubmed	Human tyrosinase gene, mapped to chromosome 11 (q14----q21), defines second region of homology with mouse chromosome 7.	ACP2 HRAS	8.48e-04	14	108	2	3146546
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ILF3 RADX CPEB3 LARP1 HNRNPUL1 SUPT5H RBM15B PDCD11 NOL8	9.45e-04	807	108	9	22681889
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	RADX ARHGEF5 CBX2 AGAP3	9.49e-04	139	108	4	25476789
Pubmed	The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.	ILF3 LARP1 HNRNPUL1	9.64e-04	62	108	3	19710015
Pubmed	SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons.	RUSC1 EGR2	9.77e-04	15	108	2	24623780
Pubmed	TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.	ILF3 DNMT3A	1.11e-03	16	108	2	31823782
Pubmed	Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival.	TEAD2 EGR2	1.11e-03	16	108	2	18332127
Pubmed	A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.	APBA2 EGR2	1.26e-03	17	108	2	22832960
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	TEAD2 BAZ2B SHC3 TTBK2 C9orf43 EGR2 TMEM184C PADI2	1.37e-03	686	108	8	29987050
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	RADX APBA2 ANKLE2 MEIOC CAMSAP1	1.41e-03	263	108	5	34702444
Pubmed	Signal transduction by the neurotrophin receptors.	RAPGEF1 HRAS	1.42e-03	18	108	2	9069267
Pubmed	G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway.	RAPGEF1 HRAS	1.42e-03	18	108	2	14712229
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	OGT FBRS MAML1 CHD3 RAI1	1.53e-03	268	108	5	33640491
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	FBRS MAML1 LARP1 SOWAHC NCOR2 SUPT5H	1.55e-03	398	108	6	35016035
Pubmed	Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain.	UTF1 DNMT3A	1.58e-03	19	108	2	23665319
Pubmed	The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development.	IRX4 ATP2B1	1.58e-03	19	108	2	16182275
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	HTR7 CPEB3 CDH23 FBH1 GPR158 ACSL5	1.92e-03	415	108	6	16385451
Pubmed	Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.	NCOR2 EGR2	1.93e-03	21	108	2	30254164
Pubmed	Schwann cell myelination requires integration of laminin activities.	EGR2 FGF2	1.93e-03	21	108	2	22767514
Pubmed	Large-scale concatenation cDNA sequencing.	ILF3 OGT ACP2 APBA2 SUPT5H VAMP4 ATP2B1	2.01e-03	568	108	7	9110174
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	MINK1 RAPGEF1 GAL3ST4 GPR158 HRAS CAMSAP1 ATP2B1	2.03e-03	569	108	7	30639242
Pubmed	FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.	EGR2 MTCL1	2.12e-03	22	108	2	26494785
Pubmed	A "double adaptor" method for improved shotgun library construction.	ILF3 OGT ACP2 APBA2 SUPT5H VAMP4 ATP2B1	2.14e-03	574	108	7	8619474
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	OGT TFCP2L1 SUPT5H UTF1	2.30e-03	177	108	4	26206133
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	OGT KAT6A FBRS APBA2 CHD3 SOWAHC NCOR2 PADI2 RAI1 AGAP3	2.52e-03	1116	108	10	31753913
Pubmed	The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.	EGR2 UTF1	2.52e-03	24	108	2	16582099
Pubmed	BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.	RADX NCOR2	2.52e-03	24	108	2	33722704
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	ILF3 LARP1 RUSC1 MTCL1	2.55e-03	182	108	4	31067453
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ILF3 FBRS LARP1 HNRNPUL1 SUPT5H CAMSAP1	2.56e-03	440	108	6	34244565
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RADX KAT6A LARP1 CHD3 HNRNPUL1 RBM15B PDCD11 NOL8	2.57e-03	759	108	8	35915203
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	8.45e-14	149	109	11	chr17q12
Cytoband	17q12	TBC1D3 TBC1D3H TBC1D3C TBC1D3B TBC1D3F	4.12e-06	99	109	5	17q12
Cytoband	3p21.2	DOCK3 RBM15B	9.30e-04	19	109	2	3p21.2
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	4.79e-04	10	60	2	830
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	NCOR2 MYPOP CHD6	7.23e-04	53	60	3	532
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	OPHN1 AGAP3	1.43e-03	17	60	2	1291
GeneFamily	PHD finger proteins	BAZ2B KAT6A CHD3	3.33e-03	90	60	3	88
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	BAZ2B KAT6A CPEB3 MAML1 MAST4 MTCL1 SUCO ATP2B1 TMCC1	3.72e-06	300	106	9	M8702
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	DOCK3 TBC1D3 HCN3 CPEB3 APBA2 RUSC1 CHD3 HIVEP3 MAST4 GPR158 RASA4 ZFHX2 FRMPD3 ATP2B1 GOLGA3 RAI1	9.40e-06	1106	106	16	M39071
Coexpression	GSE27670_BLIMP1_VS_LMP1_TRANSDUCED_GC_BCELL_UP	ACP2 GMIP EGR2 RASA4 RAI1 BMP15 DNMT3A	1.75e-05	200	106	7	M8209
Coexpression	NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP	TBC1D3 TBC1D3H DET1 BAZ2B MAML1 TBC1D3C RASA4 RASA4B TBC1D3F	1.87e-05	367	106	9	M41159
CoexpressionAtlas	Mesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D ACP2 UVSSA TBC1D3C TBC1D3B RASA4 RASA4B TBC1D3G ATP2B1 TBC1D3K TBC1D3F	1.48e-10	281	107	14	PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D ACP2 UVSSA TBC1D3C TBC1D3B RASA4 RASA4B TBC1D3G ATP2B1 TBC1D3K TBC1D3F	1.48e-10	281	107	14	PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	7.49e-10	90	107	9	PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B RASA4 RASA4B TBC1D3G RAI1 TBC1D3K TBC1D3F	8.18e-10	213	107	12	PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B RASA4 RASA4B TBC1D3G RAI1 TBC1D3K TBC1D3F	8.18e-10	213	107	12	PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	DE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGEF5 TBC1D3C TBC1D3B RASA4 RASA4B TBC1D3G TBC1D3K TBC1D3F	3.48e-09	242	107	12	PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	DOCK3 DENND2A TBC1D3 TBC1D3H DET1 TBC1D3L TBC1D3D KAT6A FBRS APBA2 TBC1D3C TBC1D3B RASA4 RASA4B SUCO TBC1D3G TBC1D3K TBC1D3F CBX2	1.62e-06	1075	107	19	PCBC_ratio_ECTO_vs_DE_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G RAI1 TBC1D3K TBC1D3F	5.07e-06	320	107	10	PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05	DOCK3 DENND2A OGT TBC1D3 TBC1D3H DET1 TBC1D3L TBC1D3D KAT6A FBRS APBA2 TBC1D3C TBC1D3B RASA4 RASA4B SUCO TBC1D3G ATP2B1 RAI1 TBC1D3K TBC1D3F	1.15e-05	1466	107	21	PCBC_ratio_ECTO_vs_SC_cfr-2X-p05
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a\|Striatum / BrainAtlas - Mouse McCarroll V32	HTR7 SHC3 EGR2 HRAS ATP2B1	7.27e-06	109	109	5	e8e0f2c5f8c9e45f2b4d173569c94275eedfe432
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2A ABI3BP SHISA9 TFCP2L1 MAST4 BHMT2	7.40e-06	190	109	6	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2A CPEB3 SHISA9 TFCP2L1 MAST4 MTCL1	7.62e-06	191	109	6	963f4f2e852bbb4faf070aafb0d368297abacd3b
Drug	Dantrolene sodium salt [14663-23-1]; Up 200; 11.8uM; PC3; HT_HG-U133A	DENND2A KAT6A CPEB3 MAML1 HIVEP3 CAMSAP1 PADI2 DNMT3A	2.47e-06	198	99	8	4343_UP
Disease	selective IgA deficiency disease	CDH23 MAST4 EGR2	4.58e-04	46	96	3	EFO_1001929
Disease	Pneumoconiosis	CDH23 HS3ST6	9.29e-04	14	96	2	C0032273
Disease	Bagassosis	CDH23 HS3ST6	9.29e-04	14	96	2	C0004681
Disease	macrophage inflammatory protein 1b measurement	DOCK3 TBC1D3 TBC1D3B TBC1D3F	1.03e-03	136	96	4	EFO_0008219
Disease	DiGeorge syndrome (implicated_via_orthology)	ZNF366 KAT6A	1.73e-03	19	96	2	DOID:11198 (implicated_via_orthology)
Disease	CCL4 measurement	TBC1D3 TBC1D3F	1.92e-03	20	96	2	EFO_0004751
Disease	temperament and character inventory	APBA2 EGR2	2.76e-03	24	96	2	EFO_0004825
Disease	urinary albumin to creatinine ratio	WIPF3 HNRNPUL1 SOWAHC RASIP1	2.82e-03	179	96	4	EFO_0007778
Disease	xanthosine measurement	HTR7 TFCP2L1	2.99e-03	25	96	2	EFO_0010549

Protein segments in the cluster

Peptide	Gene	Start	Entry
GRTVRGHPRKKLFPE	TMEM184C	351	Q9NVA4
HLAPPEKRKGRPEPS	CEP295NL	216	Q96MC4
HRRKKSTGTPRPDGP	AGAP3	546	Q96P47
LAGKRPKAPRGEEAH	ANKLE2	711	Q86XL3
KPHAGALEERGPRPV	C16orf86	81	Q6ZW13
PGRKRKHPPVESGDT	DNMT3A	51	Q9Y6K1
EEQHPLGTPTPGRKR	BAZ2B	1276	Q9UIF8
HPGPSDTVVFREKKP	ARHGEF5	1061	Q12774
CGSRDKKPRDLFGPP	C1QTNF12	91	Q5T7M4
KHPGDPQRGFKPKTR	APBA2	291	Q99767
EKPPCFLRKFSPDGR	DET1	56	Q7L5Y6
KGKAEAAPPLRPEHF	CAMSAP1	921	Q5T5Y3
LRFRHKPPVELKGPD	CDH23	3266	Q9H251
SKILPPEKEGGLPRH	ATP2B1	526	P20020
HKLRKLNPPDESGPG	HRAS	166	P01112
PPVKEGPLFIHRTKG	RASA4	566	O43374
PKPGAGSKLSDRPLH	RAI1	1206	Q7Z5J4
RKEGGSPRFGKLHLP	RASIP1	6	Q5U651
KHPVPARARDKPRGS	RBM15B	46	Q8NDT2
PPVKEGPLFIHRTKG	RASA4B	566	C9J798
RDLHGTAGPDRKPFP	EGR2	236	P11161
KPPFHSLDGGLERVP	IRX4	276	P78413
RPFLKDLHARPAAPG	MTCL1	46	Q9Y4B5
IKRPAPRPLAHHKEG	OPHN1	706	O60890
KPERPLRGGKSHYLA	RADX	176	Q6NSI4
GDLFPGHKKTRREAP	MAML1	131	Q92585
KSHLEGELRPKQPGP	NCOR2	2076	Q9Y618
PEPRHIPANRGEIKG	LARP1	276	Q6PKG0
EGSPLRRTPLPKHFE	GMIP	921	Q9P107
RERTPKGKPHAQQPG	GPR158	36	Q5T848
PKEDRPEHYPGLGKK	CFAP65	1746	Q6ZU64
ESPGEQPRKPRLLGH	BMP15	51	O95972
PGSARLFPLPGRDHK	MEGF8	786	Q7Z7M0
KKPPLRRPHSVIGGS	CDK17	66	Q00537
RRGEFSDFHGPPKKI	NOL8	206	Q76FK4
PHKGFPVVLDSPRDG	PADI2	361	Q9Y2J8
PIPKSGPEPKRRHLG	HCN3	36	Q9P1Z3
LPFPPEKRAKRGNIH	GAL3ST4	216	Q96RP7
PKVGSLGLPAHPREK	GOLGA3	221	Q08378
RHGDRSPVKTYPKDP	ACP2	41	P11117
NPGRIALPKPRNHGK	KAT6A	76	Q92794
QIPDHFRPPLRKPGK	FBRS	71	Q9HAH7
DPNHGLYPKPRTKRG	FBH1	36	Q8NFZ0
APERGFLPPASEKHG	BHMT2	306	Q9H2M3
KRGPRGRETHPVPQK	CBX2	131	Q14781
PEPEGSEEKPKARHR	CC2D2A	201	Q9P2K1
RGLHRKAPLPPGSAK	DOCK3	2001	Q8IZD9
REFHKPLVKEGGDRP	CPEB3	676	Q8NE35
PLVKEGGDRPRHVPF	CPEB3	681	Q8NE35
LPKPRRTFKHAGEGD	DENND2A	266	Q9ULE3
PKEPGLRGFLPENKF	CHD6	2411	Q8TD26
PGHKRRSKSPRVPDG	CHD3	266	Q12873
GPAKPKSSRGPFRLR	FRMPD3	1236	Q5JV73
ESPPGPRVHFRTLKG	FNDC4	126	Q9H6D8
SKFHGRPPKGLPDKS	C9orf43	91	Q8TAL5
VPVRGGPKFAAKPHN	ILF3	606	Q12906
AENLGKEHFRKPVPP	ACSL5	236	Q9ULC5
LPDPEFKRDRKGPHP	MAST4	1891	O15021
FKRDRKGPHPTARSP	MAST4	1896	O15021
SGAFPPGHFKDPKRL	FGF2	151	P09038
GPGLHTPKAEPRRRK	FAM27E3	16	Q08E93
SRPRCLGKSKGRPHP	HS3ST6	296	Q96QI5
LGKSKGRPHPRVPQA	HS3ST6	301	Q96QI5
PPYEHPKDLKLSDGR	OGT	541	O15294
EEGRKAGPPPEKRFD	HNRNPUL1	596	Q9BUJ2
KAKPDDHRSRPGRPA	MINK1	786	Q8N4C8
LKTPGRADDPHFRPL	RPH3AL	166	Q9UNE2
PAPPGKEHPRDLKFS	FOXL3	181	A0A1W2PRP0
FHELAQKRKRGPGLP	RUSC1	316	Q9BVN2
RPHPSGLREEGLEPK	MEIOC	11	A2RUB1
PFHGKIVPRDDEGRP	UVSSA	586	Q2YD98
PSGPRFGPRNDKIKH	VAMP4	41	O75379
LKRHPQPEFFGDLPR	PRAM1	366	Q96QH2
KPRPHAPDTAQFAGK	SHC3	361	Q92529
TGKPPARKDDPLHDP	SHISA9	131	B4DS77
KKGGLRELYDRGPPH	TEAD2	281	Q15562
PPGSQPFLQKKRHGR	WIPF3	351	A6NGB9
ERPVKGHSPFTLRPK	SOWAHC	506	Q53LP3
EDDDRPPKKPRHGGF	SUPT5H	61	O00267
PPKKPRHGGFILDEA	SUPT5H	66	O00267
SGPERPPEKPRKHDS	HYPK	16	Q9NX55
HRAGLPEDKGPKPFR	TBC1D3L	26	B9A6J9
FTPRKHGGEKGVPFR	TFCP2L1	176	Q9NZI6
AKHKFPGFPRVEPDS	HTR7	271	P34969
HRAGLPEDKGPKPFR	TBC1D3B	26	A6NDS4
HRAGLPEDKGPKPFR	TBC1D3H	26	P0C7X1
ESFPRGGTRKIHKPE	PDCD11	6	Q14690
GARKSADPKRPCDHP	ZNF707	86	Q96C28
PGPPLKRKHEDGSLS	ZFHX2	1826	Q9C0A1
RQLEPPAGKDGHPRD	RAPGEF1	616	Q13905
HRAGLPEDKGPKPFR	TBC1D3F	26	A6NER0
AKRFPHKKNDIPGPG	STPG1	56	Q5TH74
DKLPGSLGHPRPQEK	TTBK2	366	Q6IQ55
LKEYPQPSGKPHRRG	HIVEP3	1531	Q5T1R4
PSKEAGSRPPLARKH	HIVEP3	1971	Q5T1R4
IEPPGLFRGRGDHPK	TOP1MT	191	Q969P6
LHSRRGKPEAPKGSP	TMCC1	121	O94876
HRAGLPEDKGPKPFR	TBC1D3E	26	A0A087X179
PLHPIANGDIKGRKP	SUCO	1126	Q9UBS9
PGHPRKRAGRNEPLK	UBTD1	16	Q9HAC8
HSVKRYPDLSPGPKG	ZNF41	36	P51814
GKAPQRHPFPEALRG	ZNF366	36	Q8N895
HRAGLPEDKGPKPFR	TBC1D3D	26	A0A087WVF3
PDRGFEDHEPGPKRR	ZC3H10	196	Q96K80
HLLPEKRPKEAGPQG	PRR30	311	Q53SZ7
RETDPLGKPRFKGPH	ABI3BP	781	Q7Z7G0
ERGPTFNPKHALKPR	ZNF777	606	Q9ULD5
HRAGLPEDKGPKPFR	TBC1D3G	26	Q6DHY5
HRAGLPEDKGPKPFR	TBC1D3	26	Q8IZP1
HRAGLPEDKGPKPFR	TBC1D3K	26	A0A087X1G2
AAGHRPRKRKLSGPP	nan	241	A6NL46
HRAGLPEDKGPKPFR	TBC1D3I	26	A0A087WXS9
HRAGLPEDKGPKPFR	TBC1D3C	26	Q6IPX1
LKDKFREAHGQPPGP	UTF1	121	Q5T230
HDSPPHKRRKGFPTR	MYPOP	376	Q86VE0