Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATPase-coupled inorganic anion transmembrane transporter activity

ABCC1 ABCC4 CFTR

7.59e-05101753GO:0043225
GeneOntologyMolecularFunctionpolysaccharide binding

CLEC18A CLEC18B CLEC18C PPP1R3A

1.49e-04311754GO:0030247
DomainAnk

TANC2 CTTNBP2 DAPK1 ANKRD20A2P ANKRD20A3P RNASEL ANKRD19P ANKRD20A4P ANKRD30A PPP1R16B TNKS TANC1 ANKRD20A1 ANKRD7

2.27e-0822817014PF00023
DomainANK

TANC2 CTTNBP2 DAPK1 ANKRD20A2P ANKRD20A3P RNASEL ANKRD19P ANKRD20A4P ANKRD30A PPP1R16B TNKS TANC1 ANKRD20A1 ANKRD7

7.56e-0825117014SM00248
DomainANK_REPEAT

TANC2 CTTNBP2 DAPK1 ANKRD20A2P ANKRD20A3P RNASEL ANKRD19P ANKRD20A4P ANKRD30A PPP1R16B TNKS TANC1 ANKRD20A1 ANKRD7

8.34e-0825317014PS50088
DomainANK_REP_REGION

TANC2 CTTNBP2 DAPK1 ANKRD20A2P ANKRD20A3P RNASEL ANKRD19P ANKRD20A4P ANKRD30A PPP1R16B TNKS TANC1 ANKRD20A1 ANKRD7

8.76e-0825417014PS50297
DomainAnk_2

TANC2 CTTNBP2 DAPK1 ANKRD20A2P ANKRD20A3P RNASEL ANKRD20A4P ANKRD30A PPP1R16B TNKS TANC1 ANKRD20A1 ANKRD7

8.80e-0821517013PF12796
DomainAnkyrin_rpt

TANC2 CTTNBP2 DAPK1 ANKRD20A2P ANKRD20A3P RNASEL ANKRD19P ANKRD20A4P ANKRD30A PPP1R16B TNKS TANC1 ANKRD20A1 ANKRD7

1.28e-0726217014IPR002110
Domain-

TANC2 CTTNBP2 DAPK1 ANKRD20A2P ANKRD20A3P RNASEL ANKRD20A4P ANKRD30A PPP1R16B TNKS TANC1 ANKRD20A1 ANKRD7

4.57e-07248170131.25.40.20
DomainAnkyrin_rpt-contain_dom

TANC2 CTTNBP2 DAPK1 ANKRD20A2P ANKRD20A3P RNASEL ANKRD20A4P ANKRD30A PPP1R16B TNKS TANC1 ANKRD20A1 ANKRD7

6.00e-0725417013IPR020683
DomainMAM_1

PTPRU PTPRT EGFL6 PTPRM

1.11e-05161704PS00740
Domain-

CFAP251 BBS2 NBEA DENND3 MAPK8IP3 WDR3 LLGL1 NBEAL2 WRAP73 WDR17 TBL2 PLXNA1 FBXW7

1.18e-05333170132.130.10.10
DomainWD40/YVTN_repeat-like_dom

CFAP251 BBS2 NBEA DENND3 MAPK8IP3 WDR3 LLGL1 NBEAL2 WRAP73 WDR17 TBL2 PLXNA1 FBXW7

1.25e-0533517013IPR015943
DomainMAM

PTPRU PTPRT EGFL6 PTPRM

1.44e-05171704SM00137
DomainMAM

PTPRU PTPRT EGFL6 PTPRM

1.84e-05181704PF00629
DomainMAM_dom

PTPRU PTPRT EGFL6 PTPRM

1.84e-05181704IPR000998
DomainMAM_2

PTPRU PTPRT EGFL6 PTPRM

1.84e-05181704PS50060
DomainCFTR/ABCC7

ABCC4 CFTR

8.24e-0521702IPR009147
DomainWD40_repeat_dom

CFAP251 BBS2 NBEA DENND3 MAPK8IP3 WDR3 LLGL1 NBEAL2 WDR17 TBL2 FBXW7

9.00e-0529717011IPR017986
DomainWD40

CFAP251 NBEA DENND3 WDR3 LLGL1 NBEAL2 WRAP73 WDR17 TBL2 FBXW7

1.35e-0425917010PF00400
DomainWD40

CFAP251 NBEA DENND3 WDR3 LLGL1 NBEAL2 WRAP73 WDR17 TBL2 FBXW7

1.78e-0426817010SM00320
DomainWD40_repeat

CFAP251 NBEA DENND3 WDR3 LLGL1 NBEAL2 WRAP73 WDR17 TBL2 FBXW7

2.00e-0427217010IPR001680
DomainWD_REPEATS_1

CFAP251 NBEA DENND3 WDR3 LLGL1 NBEAL2 WRAP73 WDR17 TBL2 FBXW7

2.38e-0427817010PS00678
DomainWD_REPEATS_2

CFAP251 NBEA DENND3 WDR3 LLGL1 NBEAL2 WRAP73 WDR17 TBL2 FBXW7

2.45e-0427917010PS50082
DomainWD_REPEATS_REGION

CFAP251 NBEA DENND3 WDR3 LLGL1 NBEAL2 WRAP73 WDR17 TBL2 FBXW7

2.45e-0427917010PS50294
DomainTIL_dom

LRP2 MUC5AC OTOG

2.51e-04141703IPR002919
DomainARM-type_fold

DOCK1 ARMC7 CAND2 ATR NBEA NCDN FOCAD DNAAF5 PIK3C2A AOPEP NBEAL2

2.84e-0433917011IPR016024
DomainPTPc

PTPRU PTPRT PTPRM PTPRN

3.11e-04361704SM00194
DomainuDENN

DENND2B DENND3 MADD

3.11e-04151703PF03456
DomainCAP

CLEC18A CLEC18B CLEC18C

3.11e-04151703PF00188
DomainSCP

CLEC18A CLEC18B CLEC18C

3.11e-04151703SM00198
DomainAllrgn_V5/Tpx1

CLEC18A CLEC18B CLEC18C

3.11e-04151703IPR001283
Domain-

CLEC18A CLEC18B CLEC18C

3.11e-041517033.40.33.10
DomainCAP_domain

CLEC18A CLEC18B CLEC18C

3.11e-04151703IPR014044
DomainDENN

DENND2B DENND3 MADD

3.80e-04161703SM00799
DomainDENN

DENND2B DENND3 MADD

3.80e-04161703PF02141
DomaindDENN

DENND2B DENND3 MADD

3.80e-04161703PF03455
DomainUDENN

DENND2B DENND3 MADD

3.80e-04161703PS50946
DomainDDENN

DENND2B DENND3 MADD

3.80e-04161703PS50947
DomaindDENN

DENND2B DENND3 MADD

3.80e-04161703SM00801
DomaindDENN_dom

DENND2B DENND3 MADD

3.80e-04161703IPR005112
DomainuDENN_dom

DENND2B DENND3 MADD

3.80e-04161703IPR005113
DomainDENN

DENND2B DENND3 MADD

3.80e-04161703PS50211
DomainDENN_dom

DENND2B DENND3 MADD

3.80e-04161703IPR001194
DomainTYR_PHOSPHATASE_PTP

PTPRU PTPRT PTPRM PTPRN

4.25e-04391704PS50055
DomainPTPase_domain

PTPRU PTPRT PTPRM PTPRN

5.16e-04411704IPR000242
DomainY_phosphatase

PTPRU PTPRT PTPRM PTPRN

5.16e-04411704PF00102
DomainApc4_WD40_dom

WDR3 WRAP73 WDR17

7.54e-04201703IPR024977
DomainANAPC4_WD40

WDR3 WRAP73 WDR17

7.54e-04201703PF12894
DomainDUF4704

NBEA NBEAL2

8.09e-0451702IPR031570
DomainDUF4704

NBEA NBEAL2

8.09e-0451702PF15787
DomainTYR_PHOSPHATASE_1

DUSP9 PTPRU PTPRT PTPRM PTPRN

1.13e-03861705PS00383
DomainTYR_PHOSPHATASE_dom

DUSP9 PTPRU PTPRT PTPRM PTPRN

1.19e-03871705IPR000387
DomainTYR_PHOSPHATASE_2

DUSP9 PTPRU PTPRT PTPRM PTPRN

1.19e-03871705PS50056
DomainPH_BEACH

NBEA NBEAL2

1.21e-0361702PF14844
DomainPAK_BD

PAK2 PAK3

1.21e-0361702IPR033923
DomainABC_membrane

ABCC1 ABCC4 CFTR

1.30e-03241703PF00664
DomainEGF_3

CLEC18A CLEC18B CLEC18C EGFL6 FBLN1 OIT3 LRP2 OTOG

1.42e-032351708PS50026
Domain-

DUSP9 PTPRU PTPRT PTPRM PTPRN

1.53e-039217053.90.190.10
DomainHISTONE_H3_1

H3C1 H3-3A

1.68e-0371702PS00322
DomainPept_C14A_CASP1-typ

CASP7 CASP9

1.68e-0371702IPR017350
DomainPTPc_motif

PTPRU PTPRT PTPRM PTPRN

2.04e-03591704SM00404
DomainTyr_Pase_cat

PTPRU PTPRT PTPRM PTPRN

2.04e-03591704IPR003595
DomainEGF-like_dom

CLEC18A CLEC18B CLEC18C EGFL6 FBLN1 OIT3 LRP2 OTOG

2.05e-032491708IPR000742
DomainABC_TM1F

ABCC1 ABCC4 CFTR

2.05e-03281703PS50929
DomainABC1_TM_dom

ABCC1 ABCC4 CFTR

2.05e-03281703IPR011527
DomainDEATH-like_dom

CASP9 DAPK1 NLRP3 MADD NOD2

2.12e-03991705IPR011029
DomainProt-tyrosine_phosphatase-like

DUSP9 PTPRU PTPRT PTPRM PTPRN

2.12e-03991705IPR029021
DomainHISTONE_H3_2

H3C1 H3-3A

2.22e-0381702PS00959
DomainHistone_H3/CENP-A

H3C1 H3-3A

2.22e-0381702IPR000164
DomainPH-BEACH_dom

NBEA NBEAL2

2.22e-0381702IPR023362
DomainH3

H3C1 H3-3A

2.22e-0381702SM00428
Domain-

NBEA NBEAL2

2.22e-03817022.30.29.40
DomainPH_BEACH

NBEA NBEAL2

2.22e-0381702PS51783
DomainEGF_1

CLEC18A CLEC18B CLEC18C ITGB7 EGFL6 FBLN1 OIT3 LRP2

2.37e-032551708PS00022
DomainBEACH

NBEA NBEAL2

2.84e-0391702PS50197
DomainBeach

NBEA NBEAL2

2.84e-0391702PF02138
Domain-

NBEA NBEAL2

2.84e-03917021.10.1540.10
DomainBeach

NBEA NBEAL2

2.84e-0391702SM01026
DomainBEACH_dom

NBEA NBEAL2

2.84e-0391702IPR000409
DomainEGF_2

CLEC18A CLEC18B CLEC18C ITGB7 EGFL6 FBLN1 OIT3 LRP2

3.01e-032651708PS01186
DomainWD40_repeat_CS

DENND3 WDR3 LLGL1 WDR17 TBL2 FBXW7

3.93e-031641706IPR019775
DomainCASPASE_HIS

CASP7 CASP9

4.29e-03111702PS01121
DomainTyr_Pase_AS

PTPRU PTPRT PTPRM PTPRN

4.43e-03731704IPR016130
Domain-

PAK2 PAK3

5.12e-031217023.90.810.10
DomainCaspase_his_AS

CASP7 CASP9

5.12e-03121702IPR016129
DomainCASPASE_CYS

CASP7 CASP9

5.12e-03121702PS01122
DomainPept_C14_p10

CASP7 CASP9

5.12e-03121702IPR002138
DomainC8

MUC5AC OTOG

5.12e-03121702PF08742
DomainTIL

MUC5AC OTOG

5.12e-03121702PF01826
DomainCaspase_cys_AS

CASP7 CASP9

5.12e-03121702IPR033139
DomainCASPASE_P10

CASP7 CASP9

5.12e-03121702PS50207
DomainDUF4599

SPATA31D4 SPATA31D3

5.12e-03121702PF15371
DomainDUF4599

SPATA31D4 SPATA31D3

5.12e-03121702IPR027970
DomainEGF

CLEC18A CLEC18B CLEC18C EGFL6 FBLN1 OIT3 LRP2

5.81e-032351707SM00181
DomainCASc

CASP7 CASP9

6.01e-03131702SM00115
DomainUnchr_dom_Cys-rich

MUC5AC OTOG

6.01e-03131702IPR014853
DomainPept_C14A

CASP7 CASP9

6.01e-03131702IPR015917
DomainC8

MUC5AC OTOG

6.01e-03131702SM00832
DomainABC_transporter_CS

ABCC1 ABCC4 CFTR

6.56e-03421703IPR017871
Domain-

CASP7 CASP9

6.98e-031417023.40.50.1460
DomainPept_C14_p20

CASP7 CASP9

6.98e-03141702IPR001309
Pubmed

Expression of testicular germ cell genes identified by differential display analysis.

ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1

4.67e-088179412634303
Pubmed

Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.

CLEC18A CLEC18B CLEC18C

1.34e-073179326170455
Pubmed

Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms.

CASP7 CASP9 PAK2

1.34e-073179327889207
Pubmed

The C-type lectin-like domain superfamily.

CLEC18A CLEC18B CLEC18C

1.34e-073179316336259
Pubmed

Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.

CLEC18A CLEC18B CLEC18C

1.34e-073179333603190
Pubmed

Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1.

H3-7 H3C15 H3C1 H3-3A

2.18e-0711179415471871
Pubmed

Human PAD4 regulates histone arginine methylation levels via demethylimination.

PADI4 H3-7 H3C15 H3-3A

2.18e-0711179415345777
Pubmed

The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.

CLEC18A CLEC18B CLEC18C

5.34e-074179316709836
Pubmed

Expression patterns and post-translational modifications associated with mammalian histone H3 variants.

H3-7 H3C15 H3C1 H3-3A

6.52e-0714179416267050
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TANC2 MYCBP2 OBSCN IPP MLLT10 ELAC2 CASZ1 MADD MAPK8IP3 NOD2 FOCAD SLC6A8 C2CD3 SSU72 NBEAL2 PCYT2 TANC1 ATP2A3 MED12 PLXNA1

1.22e-0611051792035748872
Pubmed

Human spleen histone H3. Isolation and amino acid sequence.

H3-7 H3C15 H3-3A

1.33e-06517937309716
Pubmed

Modifications of human histone H3 variants during mitosis.

H3-7 H3C15 H3-3A

1.33e-065179316185088
Pubmed

Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation.

H3-7 H3C15 H3-3A

2.65e-066179310464286
Pubmed

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.

H3-7 H3C15 H3-3A

2.65e-066179315525939
Pubmed

Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase.

H3-7 H3C15 H3-3A

2.65e-066179312560483
Pubmed

The IA-2 interactome.

PTPRT MADD PTPRN

2.65e-066179316273344
Pubmed

Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification.

H3-7 H3C15 H3-3A

2.65e-066179317189264
Pubmed

Organismal differences in post-translational modifications in histones H3 and H4.

H3-7 H3C15 H3-3A

2.65e-066179317194708
Pubmed

Histone deimination antagonizes arginine methylation.

PADI4 H3C15 H3-3A

2.65e-066179315339660
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SUPT20H MYCBP2 ZNF423 TRPS1 NBEA DNAAF9 DALRD3 MADD MAPK8IP3 FOCAD PLEKHH1 WDR3 FRY AP2M1 PPP1R16B LRP2 PAK2 H3-3A TNKS WDR17 ZNF292

3.23e-0612851792135914814
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

MEF2D CASZ1 PLEKHH1 SPATA31D4 SPATA31D3 AARS2 SCAPER ZNF292 PGBD2

3.68e-06233179937704626
Pubmed

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.

H3-7 H3C15 H3C1 H3-3A

3.79e-0621179411242053
Pubmed

Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.

H3-7 H3C15 H3-3A

4.62e-067179315684425
Pubmed

Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation.

H3-7 H3C15 H3-3A

4.62e-067179311856369
Pubmed

The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.

H3-7 H3C15 H3-3A

4.62e-067179315681610
Pubmed

Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17.

H3-7 H3C15 H3-3A

4.62e-067179316497732
Pubmed

Congenital Hepatic Fibrosis Overview ─ RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

NPHP1 ZNF423 BBS2 PKHD1 BBS12

7.30e-0652179520301743
Pubmed

Semaphorin-Mediated Corticospinal Axon Elimination Depends on the Activity-Induced Bax/Bak-Caspase Pathway.

CASP7 CASP9 PLXNA1

7.37e-068179332471877
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

SUPT20H NCKAP1 DUSP9 OBSCN CASP9 NBEA NBEAL2 SHPRH ATP2A3 TBL2 MED12 ZNF292

1.14e-054971791236774506
Pubmed

PP1α, PP1β and Wip-1 regulate H4S47 phosphorylation and deposition of histone H3 variant H3.3.

H3C1 PAK2 H3-3A

1.57e-0510179323828041
Pubmed

RNase L and the NLRP3-inflammasome: An old merchant in a new trade.

NLRP3 RNASEL

2.63e-052179226987611
Pubmed

Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma.

ABCC1 ABCC4

2.63e-052179224024181
Pubmed

Therapeutic Potential for CFTR Correctors in Autosomal Recessive Polycystic Kidney Disease.

CFTR PKHD1

2.63e-052179234329764
Pubmed

Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation.

NLRP3 NOD2

2.63e-052179228403163
Pubmed

Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines.

ABCC1 ABCC4

2.63e-052179233081264
Pubmed

Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases.

ELAC2 RNASEL

2.63e-052179218767027
Pubmed

Death-associated protein kinase-mediated cell death modulated by interaction with DANGER.

DAPK1 ITPRIP

2.63e-052179220053891
Pubmed

H2O2 stimulates cystic fibrosis transmembrane conductance regulator through an autocrine prostaglandin pathway, using multidrug-resistant protein-4.

ABCC4 CFTR

2.63e-052179223742099
Pubmed

Association between RNASEL, MSR1, and ELAC2 single nucleotide polymorphisms and gene expression in prostate cancer risk.

ELAC2 RNASEL

2.63e-052179227318894
Pubmed

Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines.

CASP7 PAK2

2.63e-052179221555521
Pubmed

Synergism of NOD2 and NLRP3 activators promotes a unique transcriptional profile in murine dendritic cells.

NLRP3 NOD2

2.63e-052179220884650
Pubmed

FBW7 increases drug sensitivity to cisplatin in human nasopharyngeal carcinoma by downregulating the expression of multidrug resistance-associated protein.

ABCC1 FBXW7

2.63e-052179225586348
Pubmed

The relationship of chronic mucin secretion to airway disease in normal and CFTR-deficient mice.

CFTR MUC5AC

2.63e-05217929843919
Pubmed

Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex.

CASP7 CASP9

2.63e-052179216352606
Pubmed

PLCL1 regulates fibroblast-like synoviocytes inflammation via NLRP3 inflammasomes in rheumatoid arthritis.

NLRP3 PLCL1

2.63e-052179235820936
Pubmed

Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis.

ABCC1 ABCC4

2.63e-052179224130369
Pubmed

Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins.

TANC2 TANC1

2.63e-052179221068316
Pubmed

Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.

CLEC18A CLEC18B BMP2K CLEC18C

3.92e-0537179422432025
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TANC2 CTTNBP2 NCKAP1 MYCBP2 DAPK1 NBEA KEAP1 ZBTB1 NCDN MAPK8IP3 RAD50 FRY PAK2 PAK3 TNKS PLCL1

4.19e-059631791628671696
Pubmed

Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.

DOCK1 CTTNBP2 KEAP1 USP37 TNKS TANC1

5.51e-05128179625332235
Pubmed

Comparative analysis of apoptosis and inflammation genes of mice and humans.

CASP7 CASP9 DAPK1 MADD NOD2

6.01e-0580179512819136
Pubmed

An atlas of genetic influences on human blood metabolites.

ABCC1 ABCC4 CFAP251 ACADL SLC6A12 SLC17A1 SCAPER

6.12e-05190179724816252
Pubmed

Prognostic significance of PAK family kinases in acute myeloid leukemia.

PAK2 PAK3

7.88e-053179230890765
Pubmed

Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

ABCC1 ABCC4

7.88e-053179216156793
Pubmed

Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells.

ABCC1 ABCC4

7.88e-053179226600514
Pubmed

Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line.

CASP7 CASP9

7.88e-053179221142842
Pubmed

Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.

PAK2 PAK3

7.88e-053179215182717
Pubmed

MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands.

KEAP1 NLRP3

7.88e-053179237710276
Pubmed

Tumor suppressor death-associated protein kinase is required for full IL-1β production.

DAPK1 NLRP3

7.88e-053179221041719
Pubmed

Effect of cortisol on caspases in the co-cultured C2C12 and 3 T3-L1 cells.

CASP7 CASP9

7.88e-053179224752940
Pubmed

Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.

TANC2 TANC1

7.88e-053179238092135
Pubmed

Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.

CASP7 CASP9

7.88e-053179217371867
Pubmed

Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis.

CASP7 CASP9

7.88e-053179223834359
Pubmed

Molecular recognition of histone H3 by the WD40 protein WDR5.

H3C15 H3C1

7.88e-053179216829960
Pubmed

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.

H3C15 H3C1

7.88e-053179216829959
Pubmed

Growth arrest and DNA damage 45γ is required for caspase-dependent renal tubular cell apoptosis.

CASP7 GADD45G

7.88e-053179230794682
Pubmed

Regulation of BMP2K in AP2M1-mediated EGFR internalization during the development of gallbladder cancer.

BMP2K AP2M1

7.88e-053179232792513
Pubmed

Association of susceptibility alleles in ELAC2/HPC2, RNASEL/HPC1, and MSR1 with prostate cancer severity in European American and African American men.

ELAC2 RNASEL

7.88e-053179215824169
Pubmed

Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception.

ABCC1 ABCC4

7.88e-053179215886284
Pubmed

The expression of NOD2, NLRP3 and NLRC5 and renal injury in anti-neutrophil cytoplasmic antibody-associated vasculitis.

NLRP3 NOD2

7.88e-053179231186034
Pubmed

Inflammatory mediators ATP and S100A12 activate the NLRP3 inflammasome to induce MUC5AC production in airway epithelial cells.

NLRP3 MUC5AC

7.88e-053179229906464
Pubmed

Nucleotide oligomerization domain-2 interacts with 2'-5'-oligoadenylate synthetase type 2 and enhances RNase-L function in THP-1 cells.

NOD2 RNASEL

7.88e-053179219853919
Pubmed

Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.

NLRP3 NOD2

7.88e-053179219319132
Pubmed

The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis.

CASP7 CASP9

7.88e-053179212586738
Pubmed

Nod1, Nod2 and Nalp3 receptors, new potential targets in treatment of allergic rhinitis?

NLRP3 NOD2

7.88e-053179220384614
Pubmed

Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier.

ABCC1 ABCC4

7.88e-053179225986174
Pubmed

Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation.

PAK2 PAK3

7.88e-053179210075701
Pubmed

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.

PAK2 PAK3

7.88e-053179223335370
Pubmed

Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF.

PAK2 MUC5AC

7.88e-053179217555715
Pubmed

Group I Paks as therapeutic targets in NF2-deficient meningioma.

PAK2 PAK3

7.88e-053179225596744
Pubmed

Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men.

ELAC2 RNASEL

7.88e-053179220086112
Pubmed

Cepharanthine induces apoptosis through the mitochondria/caspase pathway in murine dendritic cells.

CASP7 CASP9

7.88e-053179227121492
Pubmed

NOD-like receptors in the human upper airways: a potential role in nasal polyposis.

NLRP3 NOD2

7.88e-053179221241317
Pubmed

Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene.

ELAC2 RNASEL

7.88e-053179215714208
Pubmed

The expression and function of Nod-like receptors in neutrophils.

NLRP3 NOD2

7.88e-053179220002790
Pubmed

The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.

PAK2 PAK3

7.88e-053179218507705
Pubmed

DAPK1 may be a potential biomarker for arterial aneurysm in clinical treatment and activated inflammation levels in arterial aneurysm through NLRP3 inflammasome by Beclin1.

DAPK1 NLRP3

7.88e-053179234796763
Pubmed

Critical role of cytosolic phospholipase A2{alpha} in bronchial mucus hypersecretion in CFTR-deficient mice.

CFTR MUC5AC

7.88e-053179220413542
Pubmed

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions.

PADI4 NLRP3

7.88e-053179234122445
Pubmed

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders.

CFTR NLRP3

7.88e-053179229021150
Pubmed

Gallium(III) complexes of α-N-heterocyclic piperidylthiosemicarbazones: Synthesis, structure-activity relationship, cellular uptake and activation of caspases-3/7/9.

CASP7 CASP9

7.88e-053179229842999
Pubmed

Molecular modeling in the age of clinical genomics, the enterprise of the next generation.

CFTR NOD2

7.88e-053179228204942
Pubmed

Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.

PAK2 PAK3

7.88e-053179238785043
Pubmed

ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.

ABCC1 ABCC4

7.88e-053179221799180
Pubmed

TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres.

ATR ACD

7.88e-053179226778124
Pubmed

Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei.

CTTNBP2 CFTR

7.88e-053179215364959
Pubmed

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.

PAK2 PAK3

7.88e-053179211278486
Pubmed

Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-9) and effector caspases (casp-3/casp-7) and PARP in UVR-exposed HaCaT keratinocytes.

CASP7 CASP9

7.88e-053179218086147
Pubmed

Knockdown of DAPK1 inhibits IL-1β-induced inflammation and cartilage degradation in human chondrocytes by modulating the PEDF-mediated NF-κB and NLRP3 inflammasome pathway.

DAPK1 NLRP3

7.88e-053179236412004
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

TANC2 ABCC1 ABCC4 MARCHF6 DAPK1 PGAP4 COQ3 MADD MRPS30 LLGL1 PTPRM PAK2 ITPRIP

9.78e-057191791335337019
Cytoband1q44

OR2AK2 NLRP3 KIF28P ZBTB18 PGBD2

7.49e-0511017951q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2AK2 NLRP3 KIF28P ZBTB18 PGBD2

1.53e-041281795chr1q44
GeneFamilyAnkyrin repeat domain containing

TANC2 CTTNBP2 DAPK1 ANKRD20A2P ANKRD20A3P RNASEL ANKRD20A4P ANKRD30A PPP1R16B TNKS TANC1 ANKRD20A1 ANKRD7

2.30e-0824213113403
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRU PTPRT PTPRM PTPRN

1.43e-05211314813
GeneFamilyWD repeat domain containing

CFAP251 NBEA DENND3 WDR3 LLGL1 NBEAL2 WRAP73 WDR17 TBL2 FBXW7

2.13e-0526213110362
GeneFamilyATP binding cassette subfamily C

ABCC1 ABCC4 CFTR

1.01e-04131313807
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND2B DENND3 MADD

7.61e-04251313504
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEA NBEAL2

1.81e-03913121230
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KLHL6 IPP KEAP1 ZBTB1 ZBTB18

2.93e-031341315861
GeneFamilyKelch like|BTB domain containing

KLHL6 IPP KEAP1

3.47e-03421313617
GeneFamilyCaspases|Caspase recruitment domain containing

CASP7 CASP9

3.86e-03131312468
GeneFamilyRing finger proteins

MARCHF6 MEX3C RNF150 PCGF6 RNF125 CHFR SHPRH

3.93e-03275131758
GeneFamilyC-type lectin domain family

CLEC18A CLEC18B CLEC18C

4.78e-03471313494
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

ZC3HC1 TRIP4

5.14e-0315131226
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

DOCK1 ABCC1 SUPT20H ATR NCKAP1 BMP2K MYCBP2 MARCHF6 DAPK1 DENND2B JARID2 SEC24D BMPR1A C2CD3 PTPRM PIK3C2A TNKS TRAM2 ZBTB18 ZNF292

1.26e-0685617520M4500
CoexpressionGSE22033_WT_VS_PPARG_KO_MEF_UP

ATR CASP9 FBLN1 MYG1 GADD45G PPP1R16B PAK3 ANKRD7 ZNF292

6.91e-061951759M7694
CoexpressionGSE4984_LPS_VS_VEHICLE_CTRL_TREATED_DC_DN

NCKAP1 TCIRG1 DGKH DENND3 NLRP3 BMPR1A PTPRM NBEAL2 PPP1R16B

7.81e-061981759M6511
CoexpressionGSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_UP

CAND2 CFTR KEAP1 MADD PPP1R16B LRP2 PLCL1 TRAM2 ATP2A3

8.13e-061991759M8401
CoexpressionLAKE_ADULT_KIDNEY_C4_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S2

NBEA DGKH PTPRM SLC17A1 AOPEP PKHD1 LRP2 PLCL1

2.52e-051761758M39223
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTTNBP2 NCKAP1 BMP2K ATP8A2 TCIRG1 TRIP4 DENND3 TC2N ITPRIP

6.43e-081851799bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCellmLN-(5)_Dendritic_cell-(53)_Lymphoid_DC|mLN / shred on region, Cell_type, and subtype

ABCC4 CTTNBP2 DAPK1 ANKRD20A2P ANKRD20A3P DENND2B SLC6A12 ANKRD20A4P ANKRD20A1

1.15e-071981799da84c76afe835aeee39da04b63c03549218b5d91
ToppCellmLN-Dendritic_cell-Lymphoid_DC|mLN / Region, Cell class and subclass

ABCC4 CTTNBP2 DAPK1 ANKRD20A2P ANKRD20A3P DENND2B SLC6A12 ANKRD20A4P ANKRD20A1

1.15e-0719817993965a9f1e8a51a196e5349aaca5fa5ed1cd8ee92
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TANC2 NBEA DGKH CASZ1 PLEKHH1 TC2N TANC1 MUC5AC

6.71e-0717917986e965e424eebef50f0202cff75f458be395cfca1
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A3 ABCC4 CTTNBP2 ATP8A2 OBSCN DENND2B GADD45G PTPRM

9.71e-071881798997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

OBSCN USP37 MAPK8IP3 RNF150 AOPEP TANC1 PLCL1 FBXW7

1.05e-06190179893c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TANC2 ATP8A2 DAPK1 PTPRT FRY GADD45G PAK3 ATP2A3

1.09e-06191179854f07e4de61735051498846afb44b1798bed8144
ToppCellCOPD-Myeloid-cDC1|COPD / Disease state, Lineage and Cell class

KLHL6 TRPS1 ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P PAK3 ANKRD20A1

1.14e-061921798bd3d00b094d92463b06023361a71240851a542b8
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

DNAAF9 PTPRM SLC17A1 AOPEP SCAPER PKHD1 LRP2 PLCL1

1.14e-061921798e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DAPK1 NBEA CHKA CASZ1 GALNT13 TANC1 GALNT6 ATP2A3

1.54e-0620017980eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal|GW12 / Sample Type, Dataset, Time_group, and Cell type.

ABCC4 CFTR OBSCN CHKA RNF150 TC2N GALNT6 PHTF1

1.54e-062001798be83f442179ba4217d12f0458059586ff3130991
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTTNBP2 CFTR PTPRT GALNT13 PKHD1 LRP2 WDR17

3.92e-061601797c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTTNBP2 CFTR PTPRT GALNT13 PKHD1 LRP2 WDR17

3.92e-06160179725c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellT_cells-TFH-like_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

DOCK1 COL6A3 TRPS1 GADD45G PTPRM PIK3C2A BBS12

7.89e-061781797e2ae43e5ec31de6197f2cbd6089f944adbf0a163
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPHP1 NCKAP1 ALS2 ZBTB1 CASZ1 FBLN1 PLXNA1

8.80e-0618117973fe648db1cb8326066d8bde3ca1287c5c9af19bd
ToppCellControl-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P PPP1R16B PAK3 ANKRD20A1

9.80e-061841797c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCellCOPD-Myeloid-cDC1|World / Disease state, Lineage and Cell class

ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P PAK3 ANKRD20A1 FBXW7

9.80e-06184179742d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TANC2 ABCC4 CFTR CHKA GALNT13 SEC24D TC2N

9.80e-061841797ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCellControl-Myeloid-cDC1|Control / Disease state, Lineage and Cell class

KLHL6 ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P PAK3 ANKRD20A1

1.05e-051861797b05c394aa3573ba855abc3066739ca193883b0c3
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL6 NXPE4 PLEKHH1 FRY PTPRM PPP1R16B ATP2A3

1.09e-0518717973699d5e71d779da922920aa3160895db187bf81b
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL6 NXPE4 PLEKHH1 FRY PTPRM PPP1R16B ATP2A3

1.09e-051871797033ba52c0c2f9978784947098fa697368ae44834
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TANC2 ABCC4 CFTR CHKA GALNT13 SEC24D TC2N

1.13e-0518817974bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ACADL CFTR FRY LRRIQ1 TC2N PKHD1 LRP2

1.13e-051881797beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ACADL CFTR FRY LRRIQ1 TC2N PKHD1 LRP2

1.17e-0518917977659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

OBSCN MAPK8IP3 RNF150 AOPEP TANC1 PLCL1 FBXW7

1.17e-0518917970a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CFTR DAPK1 CHKA FRY TC2N PTPRM PKHD1

1.21e-0519017978aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCellCOPD-Myeloid-Mast|Myeloid / Disease state, Lineage and Cell class

ABCC4 CTTNBP2 NCKAP1 BMP2K CFTR TANC1 ATP2A3

1.21e-051901797379dbac19110b76079a7a53209569e060a852acb
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCC4 NXPE4 TMEM255B NOD2 RNF125 PTPRM PPP1R16B

1.21e-0519017972655df8c0883dd811fa7617301f9c4b0a4dd55ec
ToppCellCOPD-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

ABCC1 TRPS1 DGKH ZC3H7A PAK2 PLCL1 ZNF292

1.25e-0519117973ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK1 ABCC4 CTTNBP2 DAPK1 DGKH SLC6A12 PKHD1

1.25e-051911797d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ACADL CFTR FRY LRRIQ1 TC2N PKHD1 LRP2

1.25e-05191179760ff989fe99d243a3d52955223680cdd1f1917a4
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ACADL FRY LRRIQ1 TC2N PKHD1 LRP2 MUC5AC

1.29e-051921797b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 ABCC4 DAPK1 DGKH AOPEP PKHD1 FBXL2

1.38e-051941797e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ACADL CFTR FRY LRRIQ1 TC2N PKHD1 LRP2

1.38e-0519417976b286992d4bb56013c0ea5a7601d3476d806175a
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ACADL CFTR FRY LRRIQ1 TC2N PKHD1 LRP2

1.38e-051941797f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TANC2 BBS2 DGKH CASZ1 TC2N OR2A25 ZNF292

1.52e-051971797e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK1 TRPS1 NBEA FOCAD SCAPER TNKS FBXW7

1.63e-05199179794b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Interneuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

ABCC1 NCDN PTPRT SHC2 PTPRM TMPRSS7 TRAM2

1.68e-052001797a6500d0d2e8bcac92381ab771dbdee66b0e1d48e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal-Unfolded_protein_responsible_cell|GW12 / Sample Type, Dataset, Time_group, and Cell type.

CFTR OBSCN CHKA RNF150 TC2N CLUH PHTF1

1.68e-0520017976b7314c425f6b40f1301dd39cc02b0436e96a2ec
ToppCell(53)_Lymphoid_DC|World / shred on Cell_type and subtype

ABCC4 BMP2K DAPK1 ANKRD20A2P ANKRD20A3P DENND2B ANKRD20A1

2.16e-05208179730212cfacad94a7cc562a69efa73a31259851515
ToppCellTCGA-Kidney|World / Sample_Type by Project: Shred V9

CLEC18A CLEC18B SLC6A12 SLC17A1 PKHD1 LRP2

3.37e-051511796e31974c0d0a0c644205a0ee6013ab74a09d8a306
ToppCellCOVID-19-Mast_cells-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

ABCC4 CTTNBP2 BMP2K ALS2 NBEA PLCL1

4.04e-051561796bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCellCOVID-19-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

ABCC4 CTTNBP2 BMP2K ALS2 NBEA PLCL1

4.04e-051561796159504d43421ee83b9ab484816333ae549c9c2fd
ToppCellT_cells-TFH-like_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

COL6A3 TRPS1 DGKH GADD45G PTPRM BBS12

5.34e-051641796b10cf59f4cc37ca6cd0ecf71d7de278cc2bdd8b5
ToppCelldroplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BMP2K DAPK1 DGKH MADD EGFL6 PCYT2

5.52e-05165179694a5211072464fc24592bb107a853ce832e816fe
ToppCellnucseq-Immune-Hematopoietic-Granulocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ABCC4 CTTNBP2 BMP2K ALS2 NBEA PLCL1

5.52e-05165179637615622c736e43260c38016e7c9e565ac97a3e8
ToppCellnucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ABCC4 CTTNBP2 BMP2K ALS2 NBEA PLCL1

5.52e-051651796640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCellnucseq-Immune-Hematopoietic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ABCC4 CTTNBP2 BMP2K ALS2 NBEA PLCL1

5.52e-051651796f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCelldroplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP7 ALS2 DENND3 MADD PLEKHH1 TNKS

5.91e-051671796bad33497ceeab968a7eb8a48b921c6f936390743
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 TCIRG1 SEC24D TRAM2 ATP2A3 FBXW7

5.91e-0516717960130743084dbcb20e10f96715d30961122150cbf
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 TCIRG1 SEC24D TRAM2 ATP2A3 FBXW7

5.91e-0516717967bcae3797d3a0811e7f39885afdfd29ec517f11b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL6 TCIRG1 SEC24D TRAM2 ATP2A3 FBXW7

5.91e-051671796c6f0209a1ad797631fdfa3efab6db6b1d3e8e315
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

CTTNBP2 BMP2K ATP8A2 ALS2 NBEA PLCL1

6.31e-051691796fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DGKH DENND2B SLC6A12 PAK3 PLCL1 WDR17

6.52e-0517017965570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

CTTNBP2 BMP2K ATP8A2 ALS2 NBEA PLCL1

6.52e-051701796c80f6d29096c372da95a8407f402349ff1bb7018
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALS2 USP37 NCDN BBS12 TBL2 FBXW7

7.18e-0517317968bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALS2 USP37 NCDN BBS12 TBL2 FBXW7

7.18e-0517317963e3c61468e703330788a10d850ef41a85680f86d
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCC4 CAND2 PTPRT PIK3C2A ATP2A3 TBL2

7.41e-051741796f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellCOVID-19-lung-MAST|COVID-19 / Disease (COVID-19 only), tissue and cell type

KLHL6 ABCC4 CTTNBP2 BMP2K ALS2 PLCL1

7.90e-051761796473c45a381ca109207d66ed1635668b391ea0e1f
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A1CF TDRD9 GALNT13 HHATL PAK3 GPR119

8.15e-0517717961dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A1CF TDRD9 GALNT13 HHATL PAK3 GPR119

8.15e-051771796426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCell(5)_Glands_mucous|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

NXPE4 NBEA GALNT13 GALNT6 ATP2A3 MUC5AC

8.40e-051781796f0f19b0d78f2cc5df4d4c321a953a6e447d5114a
ToppCellMid-temporal_gyrus_(MTG)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNF150 SHC2 SCAPER PKHD1 PLXNA1 SYCE1

8.40e-051781796ad187db4c40b9078d54dd915c143e0172b2f47b8
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 CTTNBP2 ACADL DAPK1 PTPRT PKHD1

8.40e-051781796c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TANC2 ABCC4 CHKA GALNT13 SEC24D TC2N

8.67e-051791796fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell(5)_Epithelial_cells-(5)_Glands_mucous|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

NXPE4 NBEA GALNT13 GALNT6 ATP2A3 MUC5AC

8.94e-051801796a4118adaf4b09e2ca01b662ed60e7bbf32a24d58
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

CLEC18A ISLR2 CFTR ALS2 NBEA AARS2

8.94e-05180179612f3c4c4aa7fe03c0ef847bd4d4942c808015f5f
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC-NK_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

CLEC18A ISLR2 CFTR ALS2 NBEA AARS2

8.94e-0518017961bc01bb76d0d3f8db74f9244436d3e6d6015ed5d
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

CLEC18A ISLR2 CFTR ALS2 NBEA AARS2

8.94e-0518017962a28fbfe10a340c8662c2c8be33792f41fc09088
ToppCelldroplet-Lung-nan-3m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFTR GALNT13 EGFL6 OIT3 LRP2 TBL2

9.49e-051821796cfba75c1ffc39ac76db9e8e27394731942882b30
ToppCelldroplet-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFTR GALNT13 EGFL6 OIT3 LRP2 TBL2

9.49e-051821796d836bfdc298ecd3558a973e393a329eb8bd59d79
ToppCelldroplet-Lung-nan-3m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFTR GALNT13 EGFL6 OIT3 LRP2 TBL2

9.49e-0518217967e7c7a26460d3003cdf0c0ffb96208a566aa09a7
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFTR OBSCN GALNT13 PKHD1 LRP2 OTOG

1.01e-0418417962cbed6462fea2622871bb7e49b0df3d984239281
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFTR DAPK1 CHKA EGFL6 TC2N LRP2

1.01e-04184179649705c8fec565b16216bdf48e83e27521f52d99a
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFTR OBSCN GALNT13 PKHD1 LRP2 OTOG

1.01e-041841796ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell-4|TCGA-Uvea / Sample_Type by Project: Shred V9

DENND3 SEC24D RNF125 GADD45G PIK3C2A PHTF1

1.01e-0418417969c56753e5e668be888662e4713cf4ce44e6c58fb
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

KLHL6 TANC2 RTF2 RAD50 ANKRD20A4P PIK3C2A

1.01e-041841796ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFTR OBSCN GALNT13 PKHD1 LRP2 OTOG

1.01e-0418417962b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TANC2 ABCC4 CHKA GALNT13 TC2N GADD45G

1.01e-041841796d0c212a8fbaad24597a84018442b25c61c17ea58
ToppCellControl-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

ABCC1 TRPS1 DGKH ZC3H7A PLCL1 ZNF292

1.04e-041851796e481cacda0b6b25f5f0062b962df9a442053ac30
ToppCellIPF-Myeloid-cDC1|World / Disease state, Lineage and Cell class

ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P PAK3 ANKRD20A1

1.07e-041861796962c2dada19185628ead77c32fcb07fa95114247
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ACADL FRY LRRIQ1 TC2N PKHD1 LRP2

1.07e-041861796bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TANC2 ABCC4 CHKA GALNT13 SEC24D TC2N

1.07e-041861796e83718fabb057100835d3357df407f283d23fe16
ToppCellCF|World / Disease state, Lineage and Cell class

PADI4 DENND3 NLRP3 JARID2 ITPRIP ZNF292

1.10e-041871796eec4d4e4a658e3a61c05745167a1a5e3d39bb43e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 DAPK1 DGKH LRRIQ1 PKHD1 FBXL2

1.10e-04187179687b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ACADL PPP1R3A LRRIQ1 TC2N PKHD1 LRP2

1.10e-041871796db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 DAPK1 DGKH LRRIQ1 PKHD1 FBXL2

1.10e-04187179642a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 DAPK1 DGKH LRRIQ1 PKHD1 FBXL2

1.10e-04187179664afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCellpdx-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ABCC1 CASZ1 NOD2 JARID2 PIK3C2A PPP1R16B

1.10e-0418717967e376831a11ee72ed87abcdac631ca46ae29c250
ToppCellIPF-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P PAK3 ANKRD20A1

1.13e-04188179647bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCC4 NXPE4 TMEM255B RNF125 PTPRM PPP1R16B

1.13e-04188179620072a2a3f9ecbe727c850629f19420cf60e4bc5
ToppCellfacs-Trachea-3m-Endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCC4 NXPE4 TMEM255B RNF125 PTPRM PPP1R16B

1.13e-041881796dd817059e1b4225e84733559f7839cc973b7dfd6
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ACADL CFTR FRY LRRIQ1 TC2N PKHD1

1.13e-0418817960d86044bc340e3efb90d0022dd299873639d831c
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCC4 NXPE4 TMEM255B RNF125 PTPRM PPP1R16B

1.13e-0418817966ab5ce8569f896a0fe7a76b8b4a83661e5499b8c
ToppCellIPF-Myeloid-cDC1|IPF / Disease state, Lineage and Cell class

ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P PAK3 ANKRD20A1

1.13e-0418817962331a2bae1383820d598e93aa86c75b101069bac
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TANC2 CFTR DAPK1 EGFL6 TC2N LRP2

1.13e-041881796562f5984efdbbcb8f53ddcee033ccbf9eb678425
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCC1 ABCC4 CTTNBP2 BMP2K ALS2 GALNT6

1.17e-041891796f01158bb15df3117fae1271bf8cf8c2501422671
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFTR DAPK1 CHKA EGFL6 TC2N LRP2

1.20e-0419017968ff8c586237cf15f930416710bcff45205fe6f70
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ACADL FRY LRRIQ1 TC2N PKHD1 LRP2

1.20e-041901796c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL6A3 OBSCN PCDHA11 DGKH DENND2B EGFL6

1.20e-0419017964eb92aef1ee868f4537483d19014d947b7684612
DiseaseIntellectual Disability

TANC2 ATP8A2 NBEA MAPK8IP3 SLC6A8 FRY AP2M1 RNF125 SCAPER LRP2 PCYT2 ZNF292

9.39e-0644716612C3714756
DiseaseColorectal Carcinoma

ABCC1 ABCC4 CFTR OBSCN IPP PTPRU NCDN PTPRT BMPR1A PUS10 PKHD1 LRP2 FBXL2 ZNF292 FBXW7

1.11e-0570216615C0009402
DiseaseCiliopathies

NPHP1 ZNF423 CFTR BBS2 PKHD1 BBS12

3.83e-051101666C4277690
Diseasecortical surface area measurement

SCFD2 TANC2 CTTNBP2 MYCBP2 ATP8A2 ZNF423 DAPK1 DNAAF9 ELAC2 DENND3 FOCAD PCGF6 ANKRD19P LRRIQ1 GADD45G AOPEP PKHD1 TNKS PLCL1 ZBTB18

7.26e-05134516620EFO_0010736
Diseaseintestinal disease (is_implicated_in)

NOD2 BMPR1A

9.40e-0531662DOID:5295 (is_implicated_in)
Diseaseureteral obstruction (biomarker_via_orthology)

CASP7 CASP9 KEAP1 PAK2

1.20e-04451664DOID:5199 (biomarker_via_orthology)
DiseaseAcne Vulgaris

NLRP3 NOD2

1.87e-0441662C0001144
Disease4-hydroxyphenylpyruvate measurement

CFAP251 SLC17A1

1.87e-0441662EFO_0800120
DiseaseAcne

NLRP3 NOD2

1.87e-0441662C0702166
Diseaseresponse to radiation, pain

ABCC4 EGFL6

1.87e-0441662EFO_0003843, GO_0009314
DiseasePyoderma Gangrenosum

NLRP3 NOD2

1.87e-0441662C0085652
DiseaseProstatic Neoplasms

ABCC4 ATR CASP9 KEAP1 ELAC2 CASZ1 FBLN1 GUCD1 RNASEL LRP2 MED12 ZNF292

2.03e-0461616612C0033578
DiseaseMalignant neoplasm of prostate

ABCC4 ATR CASP9 KEAP1 ELAC2 CASZ1 FBLN1 GUCD1 RNASEL LRP2 MED12 ZNF292

2.03e-0461616612C0376358
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

MMS22L TRPS1 MLLT10 PPP1R3A GADD45G PKHD1 TNKS TRAM2 SLC37A4

2.32e-043641669EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
DiseaseCholedochal Cyst, Type I

CFTR PKHD1

3.11e-0451662C0009439
DiseaseCholedochal Cyst, Type II

CFTR PKHD1

3.11e-0451662C1257796
DiseaseCholedochal Cyst, Type III

CFTR PKHD1

3.11e-0451662C1257797
DiseaseCholedochal Cyst, Type IV

CFTR PKHD1

3.11e-0451662C1257798
DiseaseCholedochal Cyst, Type V

CFTR PKHD1

3.11e-0451662C1257799
Diseaseendometritis (biomarker_via_orthology)

CASP7 CASP9

3.11e-0451662DOID:1002 (biomarker_via_orthology)
DiseaseCholedochal Cyst

CFTR PKHD1

3.11e-0451662C0008340
DiseaseAbnormal muscle tone

MAPK8IP3 ZNF292

4.65e-0461662C0852413
DiseaseGLIOMA SUSCEPTIBILITY 1

H3C1 H3-3A

4.65e-0461662C2750850
DiseaseHidradenitis Suppurativa

NLRP3 NOD2

6.49e-0471662C0162836
Diseasepresubiculum volume

ZNF423 TRPS1 PLCL1

7.00e-04311663EFO_0009400
Diseasedisease recurrence, malaria

PTPRT PTPRM

8.61e-0481662EFO_0001068, EFO_0004952
DiseaseGlobal developmental delay

NBEA MAPK8IP3 AP2M1 PCYT2 ZBTB18

9.55e-041331665C0557874
Diseaseneuroimaging measurement

SCFD2 CLEC18A CTTNBP2 TRPS1 DUSP9 IPP MLLT10 ELAC2 DENND3 MAPK8IP3 LRRIQ1 GADD45G PKHD1 PLCL1 TBL2

1.08e-03106916615EFO_0004346
Diseasecystic fibrosis (implicated_via_orthology)

ABCC4 CFTR

1.10e-0391662DOID:1485 (implicated_via_orthology)
Diseasepulmonary sarcoidosis (is_implicated_in)

CFTR NOD2

1.10e-0391662DOID:13406 (is_implicated_in)
DiseaseAutosomal Recessive Polycystic Kidney Disease

CFTR PKHD1

1.10e-0391662C0085548
DiseaseAbnormality of nervous system morphology

MAPK8IP3 ZNF292

1.37e-03101662C4022810
Diseaseautosomal recessive polycystic kidney disease (biomarker_via_orthology)

CFTR PKHD1

1.67e-03111662DOID:0110861 (biomarker_via_orthology)
DiseaseBardet-Biedl syndrome (implicated_via_orthology)

BBS2 SCAPER

1.67e-03111662DOID:1935 (implicated_via_orthology)
Diseasebody fat percentage

MMS22L TRPS1 MLLT10 PPP1R3A GADD45G PKHD1 TNKS TRAM2 SLC37A4

1.85e-034881669EFO_0007800
DiseaseParoxysmal atrial fibrillation

CAND2 CASZ1 MEX3C AOPEP PAK2

1.93e-031561665C0235480
Diseasefamilial atrial fibrillation

CAND2 CASZ1 MEX3C AOPEP PAK2

1.93e-031561665C3468561
DiseasePersistent atrial fibrillation

CAND2 CASZ1 MEX3C AOPEP PAK2

1.93e-031561665C2585653
Diseaseserum albumin measurement

TRPS1 TCIRG1 MLLT10 CHKA NLRP3 MADD FRY LLGL1 SSU72 SLC37A4

2.00e-0359216610EFO_0004535
Diseasebody weight

DOCK1 MMS22L ZNF423 TRPS1 DUSP9 BBS2 DGKH MLLT10 PTPRT MEX3C PPP1R3A H3C1 PTPRN CHFR PLCL1 PLXNA1

2.08e-03126116616EFO_0004338
Diseaseneutrophil count

SCFD2 MYCBP2 ZNF423 PCDHA11 ZC3HC1 DGKH DENND2B MEF2D CASZ1 NLRP3 EGFL6 ZC3H7A NBEAL2 PAK2 PLCL1 PHTF1 ZNF292

2.10e-03138216617EFO_0004833
DiseaseAtrial Fibrillation

CAND2 CASZ1 MEX3C AOPEP PAK2

2.16e-031601665C0004238
Diseaseliver cirrhosis (implicated_via_orthology)

RAD50 FOCAD

2.36e-03131662DOID:5082 (implicated_via_orthology)
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

TANC2 NCKAP1 TANC1

2.66e-03491663DOID:0060037 (implicated_via_orthology)
Diseasegastric ulcer (implicated_via_orthology)

CFTR MUC5AC

2.74e-03141662DOID:10808 (implicated_via_orthology)
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

PTPRU LRP2

2.74e-03141662DOID:10976 (biomarker_via_orthology)
DiseaseBardet-Biedl syndrome (is_implicated_in)

NPHP1 BBS2

2.74e-03141662DOID:1935 (is_implicated_in)
Diseasesodium measurement

MMS22L MLLT10 PKHD1 PLCL1

2.77e-031031664EFO_0009282
DiseasePeripheral Nervous System Diseases

ABCC1 CASP9 DAPK1

3.51e-03541663C4721453
Diseasefilaggrin gene expression measurement

TRPS1 RNF150

3.58e-03161662EFO_0020899
Diseasegrip strength measurement

MMS22L TRPS1 MLLT10 PPP1R3A JARID2 GADD45G PLCL1

3.79e-033501667EFO_0006941
DiseaseBardet-Biedl syndrome 1 (disorder)

BBS2 BBS12

4.05e-03171662C2936862
Diseasecyclic adenosine monophosphate measurement

ABCC4 PTPRM

4.05e-03171662EFO_0010473
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

AP2M1 ZNF292

4.05e-03171662DOID:0060307 (is_implicated_in)
DiseaseDrug habituation

DOCK1 ABCC4 CFTR TMPRSS7

4.12e-031151664C0013170
DiseaseDrug abuse

DOCK1 ABCC4 CFTR TMPRSS7

4.12e-031151664C0013146
DiseasePrescription Drug Abuse

DOCK1 ABCC4 CFTR TMPRSS7

4.12e-031151664C4316881
DiseaseSubstance-Related Disorders

DOCK1 ABCC4 CFTR TMPRSS7

4.12e-031151664C0236969
DiseaseDrug Use Disorders

DOCK1 ABCC4 CFTR TMPRSS7

4.12e-031151664C0013222
DiseaseDrug Dependence

DOCK1 ABCC4 CFTR TMPRSS7

4.12e-031151664C1510472
DiseaseSubstance Dependence

DOCK1 ABCC4 CFTR TMPRSS7

4.12e-031151664C0038580
DiseaseSubstance Use Disorders

DOCK1 ABCC4 CFTR TMPRSS7

4.12e-031151664C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

DOCK1 ABCC4 CFTR TMPRSS7

4.12e-031151664C0029231
Diseaseblood urea nitrogen measurement

DUSP9 DAPK1 DGKH CASZ1 MRPS30 PKHD1 LRP2 TANC1

4.20e-034521668EFO_0004741
Diseasecortical thickness

CTTNBP2 MYCBP2 ZNF423 TRPS1 ZC3HC1 DNAAF9 MLLT10 ELAC2 DENND3 MAPK8IP3 LRRIQ1 GADD45G PKHD1 CLUH

4.24e-03111316614EFO_0004840
DiseaseSubstance abuse problem

DOCK1 ABCC4 CFTR TMPRSS7

4.24e-031161664C0740858
Diseaseglucose homeostasis measurement, acute insulin response measurement

PTPRM ATP2A3

4.54e-03181662EFO_0006831, EFO_0006896
DiseaseMalignant neoplasm of endometrium

ATR FBXW7

4.54e-03181662C0007103
DiseaseBardet-Biedl syndrome

BBS2 BBS12

4.54e-03181662cv:C0752166
DiseaseCarcinoma in situ of endometrium

ATR FBXW7

4.54e-03181662C0346191
DiseasePhenyllactate (PLA) measurement

DAPK1 SLC17A1

5.05e-03191662EFO_0021662
Diseasesuperior temporal gyrus volume measurement

CTTNBP2 ANKRD7

5.05e-03191662EFO_0010331
Diseasechronic obstructive pulmonary disease (is_implicated_in)

ABCC1 CFTR NOD2

5.42e-03631663DOID:3083 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
QAVHCQEEACAVILL

ANKRD20A1

106

Q5TYW2
IVECLAEHGADLNAC

DAPK1

526

P53355
LNISVDCSFNHGICD

EGFL6

396

Q8IUX8
QAVHCQEEACAVILL

ANKRD20A8P

106

Q5CZ79
AFADCTVILCEHRIE

CFTR

1391

P13569
LLGVCASVDNCRLFV

A1CF

126

Q9NQ94
ICVTRAFVDNCLQLH

ACADL

341

P28330
VACGAFHSLALVQCL

ALS2

206

Q96Q42
FHCVVEECGALFSTL

CASZ1

1031

Q86V15
QAVHCQEEACAVILL

ANKRD20A4P

106

Q4UJ75
EHVIDLETFLQCCCQ

COQ3

226

Q9NZJ6
QAVHCQEEACAVILL

ANKRD20A5P

106

A0PJZ0
CHQEACANILIDSGA

ANKRD30A

116

Q9BXX3
ICAGFLIHAIDSNSC

ACOT12

491

Q8WYK0
CQEEECATILLEHGA

ANKRD26P1

126

Q6NSI1
NHGSEDFLLVLDCCD

AOPEP

136

Q8N6M6
HVDFECLFTCLSVRQ

DENND2B

871

P78524
CVHFLVLTDVCGNRT

DENND3

61

A2RUS2
LQIFCDTCEAVARLH

BMP2K

156

Q9NSY1
AVEFLCLSCLHILAE

BBS12

541

Q6ZW61
QFDGLVELATICALC

ATP2A3

406

Q93084
CIQEFLTLLAVCHTV

ATP8A2

496

Q9NTI2
CQEEACAIILLEHGA

ANKRD19P

111

Q9H560
QGHANIISCLCVSED

CFAP251

296

Q8TBY9
VCLALAGEACHVQVV

ISLR2

566

Q6UXK2
ALAETFCLNCGIIAL

RAD50

1216

Q92878
EVVHLCCEFLKGQID

IPP

121

Q9Y573
EGACHLSCLQIASFL

ITPRIP

401

Q8IWB1
TCLACLTNLGDVHVF

LLGL1

876

Q15334
QAVHCQEEACAVILL

ANKRD20A2P

106

Q5SQ80
FCASNIIDHFICDIS

OR6C70

166

A6NIJ9
HAVCVLGTLTQLDIC

PADI4

16

Q9UM07
CGQSAECSIHLEVIV

PCDHA11

96

Q9Y5I1
AVCRECLQALDFLHS

PAK3

381

O75914
HQIFCDLVPVLSLAC

OR6K3

191

Q8NGY3
CLLITDVALEHLENC

FBXL2

351

Q9UKC9
LCSHLEVCIQDGLFG

PTPRN

46

Q16849
HFFCEVPALLSLVCQ

OR2AK2

191

Q8NG84
LCVDIQEFSCHRVVL

KLHL6

76

Q8WZ60
LFGVVNTVACLDHLD

HHATL

306

Q9HCP6
VDACLQVLTCILLEH

MADD

306

Q8WXG6
VVDQFTVCNAHVLCI

MAPK8IP3

796

Q9UPT6
IGLQTCCHIFLNLVV

NCDN

516

Q9UBB6
NISLFEEHCETLLCD

MMS22L

251

Q6ZRQ5
LVGLFEDTNLCAIHA

H3-3A

101

P84243
NGTFHCDEALACALL

MYG1

51

Q9HB07
LVGLFEDTNLCAIHA

H3-7

101

Q5TEC6
NCDFCVHGNDITLTV

PCYT2

106

Q99447
CTHNVADCAFLEGRV

PLXNA1

686

Q9UIW2
VFLHCRVLVCGVLDE

OIT3

491

Q8WWZ8
ALSTCGSHICVILLF

OR52B6

256

Q8NGF0
VAECDLVCTFFHPLL

PIK3C2A

1521

O00443
FLITGIVQVACQECH

GPR119

241

Q8TDV5
IDEALSQNCGVLVHC

DUSP9

276

Q99956
TENLLADCLQGCFVV

MARCHF6

136

O60337
CSHECNQRLVVLFGV

MED12

746

Q93074
GHNICVNLSVVCDGI

LRP2

1321

P98164
CEELLHGQLFSGCVA

MUC5AC

266

P98088
GQDVICSHTEGLICL

MUC5AC

2011

P98088
IAIDDCTFHQCVRLS

AP2M1

241

Q96CW1
ETLVEFAIGGLCNLC

ARMC7

71

Q9H6L4
CEGHQLFLCNVERSV

PGAP4

136

Q9BRR3
LVGLFEDTNLCAIHA

H3C1

101

P68431
VVGNCGLICLISHEE

OR52N2

41

Q8NGI0
ICDAATIHCLLEQEL

DGKH

1006

Q86XP1
LHGLDGCTNIQCLEL

LRRIQ1

876

Q96JM4
HVCELLNTIDVCQVF

NCKAP1

106

Q9Y2A7
LIVELHTLCDCNCSD

ITGB7

466

P26010
VHDAILEACLCGNTA

PTPRT

1136

O14522
FIHDAILEACLCGET

PTPRU

1136

Q92729
QETVCCELSSLADHG

PPP1R3A

706

Q16821
GQVITFLDAHCECTL

GALNT13

201

Q8IUC8
HSLRQDGAVCELQIC

OBSCN

3406

Q5VST9
DAEVSRHLFELCICQ

ABCC4

566

O15439
SRNEIEHCLCSNLGV

OR56B4

176

Q8NH76
GLTALHQCCIDNFEE

PPP1R16B

101

Q96T49
IDECVTGIHNCSINE

FBLN1

526

P23142
AAVCRECLQALEFLH

PAK2

346

Q13177
CAVLEIECAHGAVFV

PUS10

276

Q3MIT2
CVVVSFLCLLLIHNE

SLC37A4

176

O43826
AIVLVNSGVLHCDLC

GUCD1

146

Q96NT3
QAVHCQEEACAVILL

ANKRD20A3P

106

Q5VUR7
LTGECVHVDFNCLFN

ATR

2486

Q13535
TLTCIICQDLLHDCV

CHFR

301

Q96EP1
GHIQLICCSVDGEIR

BBS2

301

Q9BXC9
LVTQHCSGEACFLAE

C2CD3

1271

Q4AC94
DLEACCQLLSHILEV

DOCK1

876

Q14185
LCAAAAQGHFECVEL

CTTNBP2

781

Q8WZ74
VFCHNDCQEGNILLL

CHKA

301

P35790
QAEVLTFLDAHCECF

GALNT6

261

Q8NCL4
IHFTLIQAFCCENDI

GADD45G

76

O95257
QQDHGALDCCVVVIL

CASP9

221

P55211
ALDCCVVVILSHGCQ

CASP9

226

P55211
DFLENVLTCHVCLDI

COL6A3

2576

P12111
LKGHDDHVITCLQFC

FBXW7

376

Q969H0
DHVITCLQFCGNRIV

FBXW7

381

Q969H0
CITNGHCFAIIEEDD

BMPR1A

76

P36894
SELCAFLVTLHKECG

DNAAF9

761

Q5TEA3
ACANGHTDVVLFLIE

ANKRD7

66

Q92527
CFACILLSHGEENVI

CASP7

136

P55210
DLNVRCESEVFHACI

KEAP1

236

Q14145
GCLVVHVVSCEEEFQ

DALRD3

276

Q5D0E6
LACQDLRVHQLGCEV

FRY

1191

Q5TBA9
VQALVSVCHEDCGVA

DNAAF5

501

Q86Y56
SVCHEDCGVASLQLL

DNAAF5

506

Q86Y56
CLGQLDICEFLNHVE

CAND2

1101

O75155
VSCESLLHEVIVCVG

SCAPER

1261

Q9BY12
NCDGLEEAVLHTCIA

KIF28P

661

B7ZC32
CCEGLVALVAQDHAE

FOCAD

66

Q5VW36
QGLHALCQAEVVCIR

FOCAD

631

Q5VW36
SEAGIFCLVNHVSFC

NPHP1

256

O15259
SVLCDCEIALIIFNH

MEF2D

36

Q14814
FIHDAILEACLCGDT

PTPRM

1146

P28827
FLSHLAVVDIACACS

OR2A25

61

A4D2G3
ACQVDIICGDHLLEQ

PCGF6

301

Q9BYE7
ENVVFCLECALRHVE

JARID2

1156

Q92833
AEQDCVRHICLEGQL

OTOG

2056

Q6ZRI0
CGNNVIDHITCEILA

OR13D1

201

Q8NGV5
IPLCGNLIDHFTCEI

OR2K2

166

Q8NGT1
VRLECVGNCIVLFAA

ABCC1

1201

P33527
FCFVHLLCLDFTVAE

RNF150

21

Q9ULK6
ELICIAEHCTNLTAL

FBXL21P

356

Q9UKT6
GLSHECCFDISLVLS

NLRP3

781

Q96P20
ALRAVACDCLLQEHF

MRPS30

141

Q9NP92
VCHTCGAAFQEDDVI

RTF2

156

Q9BY42
CHAELELGTCFQAVN

TC2N

351

Q8N9U0
CCAIVDGVFAAQHIE

TMEM255B

101

Q8WV15
IVLGHVFGCLDECLI

TDRD9

611

Q8NDG6
HSECGLILNTNAELC

NXPE4

216

Q6UWF7
HLDVVTCLALDTCGI

NBEAL2

2501

Q6ZNJ1
HEVVCVSVCAELGLV

NBEA

2781

Q8NFP9
LVGLFEDTNLCAIHA

H3C15

101

Q71DI3
GLSFLVHCCNVIITA

SLC17A1

21

Q14916
HDCVICFENEVIAAL

MEX3C

606

Q5U5Q3
LGLDSQFVCVECLVT

SLC6A12

391

P48065
HRGHLFVCVTLCEQT

RNASEL

426

Q05823
CEEAHRQLVCALNGL

SHPRH

1016

Q149N8
CLVPEFVHSIAALLC

TANC1

516

Q9C0D5
CLVPEFVHNVAALLC

TANC2

466

Q9HCD6
HCLDIDLNFICLSGL

SPATA31D4

21

Q6ZUB0
FDCELRAVQVSCGFH

MYCBP2

936

O75592
VLAACCHLAIDNIEL

WDR17

961

Q8IZU2
DHFCLCFLETEAVVG

WRAP73

436

Q9P2S5
CVILSLGDHTILCQV

PKHD1

1431

P08F94
CVEIFRHEDCANASL

SLC6A8

181

P48029
LCEHLGVREECFAVG

SCFD2

226

Q8WU76
ALQTSVELCCGTHLL

AARS2

741

Q5JTZ9
LAKDCVAHGCSVTLF

SEC24D

621

O94855
LAHSVEVCSFLQECG

SPTBN5

996

Q9NRC6
HQGALVCLAESCLTL

ACD

181

Q96AP0
FHVTCAQFAGLLCEE

MLLT10

166

P55197
HLCSAGQAAIEAFVC

CLEC18A

166

A5D8T8
HLCSAGQTAIEAFVC

CLEC18B

166

Q6UXF7
HLCSAGQAAIEAFVC

CLEC18C

166

Q8NCF0
LCCLRQELVDAFVEH

CLUH

601

O75153
LHRICCQDAQVDLLA

PGBD2

501

Q6P3X8
DIQVHVTACILSVCG

ZC3HC1

241

Q86WB0
ADQICEDCAFSILHG

PLCL1

181

Q15111
DELSTKCVHCGIVFL

TRPS1

1211

Q9UHF7
HCLDIDLNFICLSGL

SPATA31D3

21

P0C874
PVTSFDCAVCLEVLH

RNF125

31

Q96EQ8
TCDLEEFQTCLVRHC

ELAC2

631

Q9BQ52
CLEENHLQDEGVCSL

NOD2

961

Q9HC29
LSIAFICCAQVLQGH

PHTF1

621

Q9UMS5
ACHILECCEGLAQSI

SHC2

276

P98077
AKGHIFCEDCVAAIL

TMPRSS7

186

Q7RTY8
LEDVKHQLCSLCGAE

SYCE1

206

Q8N0S2
NHADIGFCLVLCVLI

TRAM2

21

Q15035
ACSFGHAEVVSLLLC

TNKS

256

O95271
EQRHQGFLCDCTVLV

ZBTB18

16

Q99592
SQVNIFHCGCVIAEI

SUPT20H

131

Q8NEM7
CELHFLATLAQETGV

ZNF292

146

O60281
DLEHCLQGSVKICDA

PLEKHH1

1051

Q9ULM0
HLSAGETICQVCFQI

ZBTB1

656

Q9Y2K1
LEGTHELRQACQICF

ZC3H7A

436

Q8IWR0
LTGLHSVADIFCESC

YPEL4

76

Q96NS1
LASHHIGECCFQEIE

ZNF888

76

P0CJ79
FEVQHSIICKACGEI

USP37

481

Q86T82
DSVIQECVQFLGHCE

TTC30A

606

Q86WT1
LFCGTLVCTHEEQDI

TRIP4

201

Q15650
CGETFSTEVELQCHI

ZNF423

786

Q2M1K9
CHGTDSVLELFCILS

WDR3

296

Q9UNX4
GAFLICELCQCIQHT

SSU72

151

Q9NP77
ECFERVHGECIANLS

TBL2

366

Q9Y4P3
QAIHTIEFCLGCVSN

TCIRG1

716

Q13488