Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetallopeptidase activity

ANPEP ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 NPEPL1 LNPEP ADAMTS15 PAPPA ADAMTS14 AGTPBP1

7.34e-0820012911GO:0008237
GeneOntologyMolecularFunctionpeptidase activity

PCSK5 RELN USP22 ANPEP ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 NPEPL1 F11 PRSS53 LNPEP ADAMTS15 PAPPA ADAMTS14 AGTPBP1 SENP7

1.09e-0665412917GO:0008233
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 PAPPA ADAMTS14

1.29e-051201297GO:0004222
GeneOntologyMolecularFunctionendopeptidase activity

PCSK5 ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 F11 PRSS53 ADAMTS15 PAPPA ADAMTS14 SENP7

1.11e-0443012911GO:0004175
GeneOntologyMolecularFunctionlow voltage-gated calcium channel activity

CACNA1H CACNA1G

1.24e-0431292GO:0008332
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

STAB2 STAB1 SORL1

1.39e-04161293GO:0005041
GeneOntologyMolecularFunctionaminopeptidase activity

ANPEP NPEPL1 F11 LNPEP

1.69e-04431294GO:0004177
GeneOntologyMolecularFunctionlow-density lipoprotein particle binding

STAB2 STAB1 SORL1

2.00e-04181293GO:0030169
GeneOntologyMolecularFunctionphosphatidylinositol N-acetylglucosaminyltransferase activity

PIGQ PIGA

2.46e-0441292GO:0017176
GeneOntologyMolecularFunctionbeta-adrenergic receptor kinase activity

GRK2 GRK3

2.46e-0441292GO:0047696
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

STAB2 STAB1 SORL1

3.22e-04211293GO:0030228
GeneOntologyMolecularFunctionglycosaminoglycan binding

STAB2 ADAMTS1 ADAMTS5 F11 STAB1 SULF1 ADAMTS15 AGRN

3.57e-042681298GO:0005539
GeneOntologyMolecularFunctionATPase inhibitor activity

FNIP1 AGRN

6.11e-0461292GO:0042030
GeneOntologyMolecularFunctionhistone H3K9me2/H3K9me3 demethylase activity

KDM4E KDM4A

6.11e-0461292GO:0140684
GeneOntologyMolecularFunctionDNA exonuclease activity

AEN POLE FEN1

6.14e-04261293GO:0004529
GeneOntologyMolecularFunctionmetalloaminopeptidase activity

ANPEP NPEPL1 LNPEP

6.14e-04261293GO:0070006
GeneOntologyMolecularFunctiontransition metal ion binding

TCEA1 USP22 ANPEP ADAMTS4 ADAMTS1 POLE ADAMTS5 NPEPL1 LNPEP FEN1 ADAMTS15 RNF216 PAPPA KDM4A ATOX1 MUC2 NOS1 AGTPBP1

6.38e-04118912918GO:0046914
GeneOntologyMolecularFunctionexopeptidase activity

ANPEP NPEPL1 F11 LNPEP AGTPBP1

7.41e-041101295GO:0008238
GeneOntologyMolecularFunctionG protein-coupled receptor kinase activity

GRK2 GRK3

8.51e-0471292GO:0004703
GeneOntologyMolecularFunctionmetalloexopeptidase activity

ANPEP NPEPL1 LNPEP AGTPBP1

1.10e-03701294GO:0008235
GeneOntologyMolecularFunctionextracellular matrix binding

ADAMTS5 THSD1 ADAMTS15 AGRN

1.28e-03731294GO:0050840
GeneOntologyMolecularFunctionextracellular matrix structural constituent

RELN VWF SSPOP MUC2 MUC5AC AGRN

1.40e-031881296GO:0005201
GeneOntologyMolecularFunctioncuprous ion binding

ATOX1 MUC2

1.45e-0391292GO:1903136
GeneOntologyMolecularFunctionlipoprotein particle binding

STAB2 STAB1 SORL1

1.48e-03351293GO:0071813
GeneOntologyMolecularFunctionprotein-lipid complex binding

STAB2 STAB1 SORL1

1.48e-03351293GO:0071814
GeneOntologyMolecularFunctionzinc ion binding

TCEA1 USP22 ANPEP ADAMTS4 ADAMTS1 POLE ADAMTS5 LNPEP ADAMTS15 RNF216 PAPPA KDM4A NOS1 AGTPBP1

1.87e-0389112914GO:0008270
GeneOntologyCellularComponentextracellular matrix

RELN VWF ADAMTS4 ADAMTS1 ADAMTS5 SSPOP EYS SULF1 ADAMTS15 ADAMTS14 MUC2 MUC5AC AGRN OTOG

5.99e-0565613014GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

RELN VWF ADAMTS4 ADAMTS1 ADAMTS5 SSPOP EYS SULF1 ADAMTS15 ADAMTS14 MUC2 MUC5AC AGRN OTOG

6.19e-0565813014GO:0030312
GeneOntologyCellularComponentmucus layer

MUC2 MUC5AC

1.15e-0431302GO:0070701
GeneOntologyCellularComponentcollagen-containing extracellular matrix

RELN VWF ADAMTS4 ADAMTS1 ADAMTS5 SSPOP EYS SULF1 ADAMTS15 MUC2 AGRN

4.82e-0453013011GO:0062023
DomainC8

VWF SSPOP MUC2 MUC5AC OTOG

1.07e-08121285PF08742
DomainTIL

VWF SSPOP MUC2 MUC5AC OTOG

1.07e-08121285PF01826
DomainUnchr_dom_Cys-rich

VWF SSPOP MUC2 MUC5AC OTOG

1.72e-08131285IPR014853
DomainC8

VWF SSPOP MUC2 MUC5AC OTOG

1.72e-08131285SM00832
DomainADAM_Cys-rich

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 ADAMTS14

2.42e-08271286IPR006586
DomainACR

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 ADAMTS14

2.42e-08271286SM00608
DomainTIL_dom

VWF SSPOP MUC2 MUC5AC OTOG

2.66e-08141285IPR002919
DomainVWF_type-D

VWF SSPOP MUC2 MUC5AC OTOG

5.75e-08161285IPR001846
DomainVWFD

VWF SSPOP MUC2 MUC5AC OTOG

5.75e-08161285PS51233
DomainVWD

VWF SSPOP MUC2 MUC5AC OTOG

5.75e-08161285SM00216
DomainVWD

VWF SSPOP MUC2 MUC5AC OTOG

5.75e-08161285PF00094
DomainEGF_3

RELN STAB2 SSPOP CRB1 STAB1 EYS MALRD1 ASTN2 AGRN NOTCH4 OTOG SORL1

7.80e-0823512812PS50026
DomainVWC_out

VWF SSPOP MUC2 MUC5AC OTOG

1.50e-07191285SM00215
DomainTSP_1

ADAMTS4 ADAMTS1 ADAMTS5 THSD1 SSPOP ADAMTS15 ADAMTS14

2.42e-07631287PF00090
DomainPep_M12B_propep

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 ADAMTS14

2.50e-07391286PF01562
DomainPeptidase_M12B_N

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 ADAMTS14

2.50e-07391286IPR002870
DomainDISINTEGRIN_1

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 ADAMTS14

2.92e-07401286PS00427
DomainReprolysin

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 ADAMTS14

2.92e-07401286PF01421
DomainADAM_MEPRO

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 ADAMTS14

2.92e-07401286PS50215
DomainDISINTEGRIN_2

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 ADAMTS14

2.92e-07401286PS50214
DomainPeptidase_M12B

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 ADAMTS14

2.92e-07401286IPR001590
DomainTSP1

ADAMTS4 ADAMTS1 ADAMTS5 THSD1 SSPOP ADAMTS15 ADAMTS14

3.01e-07651287SM00209
DomainTSP1_rpt

ADAMTS4 ADAMTS1 ADAMTS5 THSD1 SSPOP ADAMTS15 ADAMTS14

3.01e-07651287IPR000884
DomainTSP1

ADAMTS4 ADAMTS1 ADAMTS5 THSD1 SSPOP ADAMTS15 ADAMTS14

3.01e-07651287PS50092
DomainDisintegrin_dom

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 ADAMTS14

3.40e-07411286IPR001762
DomainZINC_PROTEASE

ANPEP ADAMTS4 ADAMTS1 ADAMTS5 LNPEP ADAMTS15 PAPPA ADAMTS14

3.67e-07981288PS00142
DomainADAM_spacer1

ADAMTS4 ADAMTS1 ADAMTS5 ADAMTS15 ADAMTS14

4.26e-07231285IPR010294
DomainADAM_spacer1

ADAMTS4 ADAMTS1 ADAMTS5 ADAMTS15 ADAMTS14

4.26e-07231285PF05986
DomainPeptidase_M12B_ADAM-TS

ADAMTS4 ADAMTS1 ADAMTS5 ADAMTS15 ADAMTS14

5.35e-07241285IPR013273
DomainEGF

PCSK5 RELN STAB2 GPR179 CRB1 STAB1 EYS MALRD1 AGRN NOTCH4 SORL1

6.62e-0723512811SM00181
DomainCys_knot_C

VWF SSPOP MUC2 MUC5AC OTOG

6.65e-07251285IPR006207
DomainCTCK_2

VWF SSPOP MUC2 MUC5AC OTOG

6.65e-07251285PS01225
DomainEGF-like_dom

PCSK5 RELN STAB2 CRB1 STAB1 EYS MALRD1 AGRN NOTCH4 OTOG SORL1

1.17e-0624912811IPR000742
Domain-

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 PAPPA ADAMTS14

1.37e-068112873.40.390.10
DomainMetalloPept_cat_dom

ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 ADAMTS15 PAPPA ADAMTS14

1.37e-06811287IPR024079
DomainEGF_2

RELN STAB2 SSPOP CRB1 STAB1 EYS MALRD1 ASTN2 AGRN NOTCH4 SORL1

2.14e-0626512811PS01186
DomainCTCK_1

VWF SSPOP MUC2 MUC5AC

5.98e-06181284PS01185
DomainVWF_dom

VWF SSPOP MUC2 MUC5AC OTOG

9.70e-06421285IPR001007
DomainEGF_1

RELN STAB2 SSPOP CRB1 STAB1 EYS MALRD1 ASTN2 AGRN NOTCH4

1.04e-0525512810PS00022
DomainCT

VWF MUC2 MUC5AC OTOG

1.40e-05221284SM00041
DomainEGF

STAB2 CRB1 STAB1 EYS MALRD1 AGRN NOTCH4

2.59e-051261287PF00008
DomainCell_morpho_N

FRYL FRY

4.66e-0521282IPR025614
DomainCell_Morphogen_C

FRYL FRY

4.66e-0521282IPR025481
DomainMOR2-PAG1_mid

FRYL FRY

4.66e-0521282IPR029473
DomainMOR2-PAG1_mid

FRYL FRY

4.66e-0521282PF14228
DomainMOR2-PAG1_C

FRYL FRY

4.66e-0521282PF14225
DomainMOR2-PAG1_N

FRYL FRY

4.66e-0521282PF14222
DomainEGF-like_CS

RELN STAB2 CRB1 STAB1 EYS MALRD1 AGRN NOTCH4 SORL1

7.94e-052611289IPR013032
DomainGrowth_fac_rcpt_

PCSK5 STAB2 GPR179 CRB1 STAB1 EYS NOTCH4

1.01e-041561287IPR009030
DomainVWFC_1

VWF SSPOP MUC2 MUC5AC

1.05e-04361284PS01208
DomainVWFC_2

VWF SSPOP MUC2 MUC5AC

1.30e-04381284PS50184
DomainVWC

VWF SSPOP MUC2 MUC5AC

1.30e-04381284SM00214
DomainConA-like_dom

NPTX1 RYR1 CRB1 EYS MALRD1 PAPPA AGRN RFPL2

1.35e-042191288IPR013320
DomainVDCC_T_a1

CACNA1H CACNA1G

1.39e-0431282IPR005445
DomainEGF_CA

STAB2 CRB1 STAB1 EYS AGRN NOTCH4

1.95e-041221286SM00179
DomainEGF-like_Ca-bd_dom

STAB2 CRB1 STAB1 EYS AGRN NOTCH4

2.13e-041241286IPR001881
DomainFAS1

STAB2 STAB1

2.77e-0441282SM00554
DomainFAS1_domain

STAB2 STAB1

2.77e-0441282IPR000782
Domain-

STAB2 STAB1

2.77e-04412822.30.180.10
DomainFAS1

STAB2 STAB1

2.77e-0441282PS50213
DomainFasciclin

STAB2 STAB1

2.77e-0441282PF02469
Domain-

NPTX1 CRB1 EYS PAPPA AGRN

4.95e-049512852.60.120.200
DomainWxxW_domain

MUC2 MUC5AC

6.87e-0461282IPR025155
DomainMucin2_WxxW

MUC2 MUC5AC

6.87e-0461282PF13330
DomainhEGF

CRB1 EYS NOTCH4

9.09e-04281283PF12661
DomainNotch_dom

PAPPA NOTCH4

9.57e-0471282IPR000800
DomainMob1_phocein

MOB1B MOB1A

9.57e-0471282PF03637
DomainGPCR_kinase

GRK2 GRK3

9.57e-0471282IPR000239
DomainNotch

PAPPA NOTCH4

9.57e-0471282PF00066
DomainMOB_kinase_act_fam

MOB1B MOB1A

9.57e-0471282IPR005301
Domain-

MOB1B MOB1A

9.57e-04712821.20.140.30
DomainMob1_phocein

MOB1B MOB1A

9.57e-0471282SM01388
DomainNL

PAPPA NOTCH4

9.57e-0471282SM00004
DomainEGF_LAM_2

STAB2 STAB1 AGRN

1.11e-03301283PS50027
DomainEGF_LAM_1

STAB2 STAB1 AGRN

1.11e-03301283PS01248
DomainERAP1-like_C_dom

ANPEP LNPEP

1.27e-0381282IPR024571
DomainERAP1_C

ANPEP LNPEP

1.27e-0381282PF11838
DomainSialidases

RELN SORL1

1.63e-0391282IPR011040
DomainEGF_Lam

STAB2 STAB1 AGRN

1.75e-03351283SM00180
DomainJmjN

KDM4E KDM4A

2.02e-03101282SM00545
DomainJmjN

KDM4E KDM4A

2.02e-03101282PF02375
DomainJMJN

KDM4E KDM4A

2.02e-03101282PS51183
DomainVDCCAlpha1

CACNA1H CACNA1G

2.02e-03101282IPR002077
DomainJmjN

KDM4E KDM4A

2.02e-03101282IPR003349
DomainLAM_G_DOMAIN

CRB1 EYS AGRN

2.23e-03381283PS50025
DomainLaminin_EGF

STAB2 STAB1 AGRN

2.23e-03381283IPR002049
DomainGFP-like

STAB2 STAB1

2.46e-03111282IPR023413
Domain-

STAB2 STAB1

2.46e-031112822.40.155.10
DomainLaminin_G_1

EYS AGRN

2.46e-03111282PF00054
DomainLDLR_class-A_CS

SSPOP MALRD1 SORL1

2.58e-03401283IPR023415
DomainEGF_dom

STAB2 STAB1

2.94e-03121282IPR024731
DomainEGF_3

STAB2 STAB1

2.94e-03121282PF12947
DomainPeptidase_M1

ANPEP LNPEP

2.94e-03121282IPR001930
DomainLamG

CRB1 EYS AGRN

3.39e-03441283SM00282
DomainKelch_2

KLHDC2 KLHL31

3.46e-03131282IPR011498
DomainLink_dom

STAB2 STAB1

3.46e-03131282IPR000538
DomainXlink

STAB2 STAB1

3.46e-03131282PF00193
DomainKelch_2

KLHDC2 KLHL31

3.46e-03131282PF07646
DomainLINK_2

STAB2 STAB1

3.46e-03131282PS50963
DomainPeptidase_M1_N

ANPEP LNPEP

3.46e-03131282IPR014782
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS4 ADAMTS1 ADAMTS5 THSD1 SSPOP ADAMTS15 ADAMTS14 MUC5AC NOTCH4

7.61e-1068969M27303
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS4 ADAMTS1 ADAMTS5 THSD1 SSPOP ADAMTS15 ADAMTS14

7.01e-0939967M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS4 ADAMTS1 ADAMTS5 THSD1 SSPOP ADAMTS15 ADAMTS14

7.01e-0939967MM15165
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS4 ADAMTS1 ADAMTS5 THSD1 SSPOP ADAMTS15 ADAMTS14 MUC5AC AGRN NOTCH4

4.51e-081439610M27275
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS4 ADAMTS1 ADAMTS5 THSD1 SSPOP ADAMTS15 ADAMTS14 MUC2 MUC5AC

5.24e-08109969MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS4 ADAMTS1 ADAMTS5 THSD1 SSPOP ADAMTS15 ADAMTS14 MUC5AC

8.55e-07111968M27416
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS4 ADAMTS1 ADAMTS5 THSD1 SSPOP ADAMTS15 ADAMTS14 MUC5AC AGRN NOTCH4

7.61e-062509610M27554
Pubmed

Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion.

ADAMTS4 ADAMTS1 ADAMTS5 ADAMTS15

1.37e-088132423233679
Pubmed

Regulation of ADAMTS-1, -4 and -5 expression in human macrophages: differential regulation by key cytokines implicated in atherosclerosis and novel synergism between TL1A and IL-17.

ADAMTS4 ADAMTS1 ADAMTS5

5.34e-083132323859810
Pubmed

Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina.

ADAMTS4 ADAMTS1 ADAMTS5

5.34e-083132321345877
Pubmed

Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation.

ADAMTS4 ADAMTS1 ADAMTS5

5.34e-083132315659705
Pubmed

Expression of ADAMTS-1, ADAMTS-4, ADAMTS-5 and TIMP3 by hepatocellular carcinoma cell lines.

ADAMTS4 ADAMTS1 ADAMTS5

2.13e-074132322735305
Pubmed

Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators.

RELN ADAMTS4 ADAMTS5

2.13e-074132323082219
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS4 ADAMTS1 ADAMTS5 SSPOP ADAMTS15 ADAMTS14

4.33e-0775132620637190
Pubmed

Cell-specific and developmental expression of lectican-cleaving proteases in mouse hippocampus and neocortex.

ADAMTS4 ADAMTS5 ADAMTS15

5.31e-075132325349050
Pubmed

[ADAMTS family--new extracellular matrix degrading enzyme].

ADAMTS4 ADAMTS1 ADAMTS5

5.31e-075132311831030
Pubmed

Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells.

ADAMTS4 ADAMTS1 ADAMTS5

5.31e-075132322562232
Pubmed

ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.

ADAMTS4 ADAMTS1 ADAMTS5 ADAMTS15

9.16e-0720132419922873
Pubmed

The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican.

ADAMTS1 ADAMTS5 ADAMTS15

1.85e-067132315599946
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ICOSLG ADAMTS4 HECTD4 ACOT11 ASTN2 KDM4A

2.66e-0610213269734811
Pubmed

Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.

ADAMTS1 ADAMTS5 ADAMTS15

8.62e-0611132329337306
Pubmed

Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.

ADAMTS4 ADAMTS1 ADAMTS5

1.15e-0512132332648916
Pubmed

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.

ADAMTS4 ADAMTS1 ADAMTS5

1.15e-0512132325770910
Pubmed

Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.

ADAMTS4 ADAMTS1 ADAMTS5 RBPJ

1.32e-0538132429743679
Pubmed

Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases.

ADAMTS4 ADAMTS5

1.43e-052132224786121
Pubmed

Shared and specific signatures of locomotor ataxia in mutant mice.

RELN AGTPBP1

1.43e-052132232718435
Pubmed

Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period.

CACNA1H CACNA1G

1.43e-052132214988077
Pubmed

Association of ADAMTS4 and ADAMTS5 polymorphisms with musculoskeletal degenerative diseases: a systematic review and meta-analysis.

ADAMTS4 ADAMTS5

1.43e-052132230369484
Pubmed

Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice.

CACNA1H CACNA1G

1.43e-052132221622683
Pubmed

FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.

STAB2 STAB1

1.43e-052132212473645
Pubmed

Structure analysis reveals the flexibility of the ADAMTS-5 active site.

ADAMTS4 ADAMTS5

1.43e-052132221370305
Pubmed

Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis.

RBPJ NOTCH4

1.43e-052132218836481
Pubmed

Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2).

ADAMTS4 ADAMTS5

1.43e-052132226612259
Pubmed

The coexpression of reelin and neuronal nitric oxide synthase in a subpopulation of dentate gyrus neurons is downregulated in heterozygous reeler mice.

RELN NOS1

1.43e-052132221331324
Pubmed

Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.

CACNA1H CACNA1G

1.43e-052132220685979
Pubmed

Expression Levels of A Disintegrin-like Metalloproteinase with Thrombospondin Motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in Inflamed and Healthy Gingival Tissues.

ADAMTS4 ADAMTS5

1.43e-052132232067610
Pubmed

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.

ADAMTS4 ADAMTS5

1.43e-052132211801682
Pubmed

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.

ADAMTS4 ADAMTS5

1.43e-052132218042673
Pubmed

Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.

ADAMTS4 ADAMTS5

1.43e-052132211956193
Pubmed

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

ADAMTS4 ADAMTS5

1.43e-052132217430884
Pubmed

Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways.

RBPJ NOTCH4

1.43e-052132214701863
Pubmed

Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver.

STAB2 STAB1

1.43e-052132221427291
Pubmed

Mucolytic activity of bacterial and human chitinases.

MUC2 MUC5AC

1.43e-052132217321686
Pubmed

Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma.

MUC2 MUC5AC

1.43e-052132220731025
Pubmed

Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles.

CACNA1H CACNA1G

1.43e-052132223436820
Pubmed

Modeling ADAMTS13-von Willebrand factor interaction: Implications for oxidative stress-related cardiovascular diseases and type 2A von Willebrand disease.

VWF ADAMTS1

1.43e-052132221937160
Pubmed

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.

ADAMTS4 ADAMTS5

1.43e-052132210438522
Pubmed

Expression of nNOS and soluble guanylate cyclase in schizophrenic brain.

GUCY1A2 NOS1

1.43e-052132215094474
Pubmed

Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding.

STAB2 STAB1

1.43e-052132215572036
Pubmed

Phenotypical and biochemical characterization of murine psoriasiform and fibrotic skin disease models in Stabilin-deficient mice.

STAB2 STAB1

1.43e-052132238946049
Pubmed

Deficiency of T-type Ca2+ channels Cav3.1 and Cav3.2 has no effect on angiotensin II-induced hypertension but differential effect on plasma aldosterone in mice.

CACNA1H CACNA1G

1.43e-052132231042060
Pubmed

Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.

GRK2 GRK3

1.43e-052132210198406
Pubmed

Variable phenotype of del45-55 Becker patients correlated with nNOSμ mislocalization and RYR1 hypernitrosylation.

RYR1 NOS1

1.43e-052132222589245
Pubmed

FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities.

STAB2 STAB1

1.43e-052132212077138
Pubmed

G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.

GRK2 GRK3

1.43e-052132211762794
Pubmed

Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins.

MUC2 MUC5AC

1.43e-052132223832517
Pubmed

Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution.

MUC2 MUC5AC

1.43e-052132223832516
Pubmed

Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa.

RBPJ NOTCH4

1.43e-052132215187023
Pubmed

Scavenging Endothelium of Pancreatic Islets: Differential Expression of Stabilin-1 and Stabilin-2 in Mice and Humans.

STAB2 STAB1

1.43e-052132227977633
Pubmed

The role of LNPEP and ANPEP gene polymorphisms in the pathogenesis of pre-eclampsia.

ANPEP LNPEP

1.43e-052132232619880
Pubmed

Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis.

MUC2 MUC5AC

1.43e-052132217203232
Pubmed

Cloning of GRK2 cDNA from S49 murine lymphoma cells.

GRK2 GRK3

1.43e-05213228638670
Pubmed

Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling.

MOB1B MOB1A

1.43e-052132230349003
Pubmed

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.

MOB1B MOB1A

1.43e-052132223143302
Pubmed

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform-dependent manner.

RELN ADAMTS4

1.43e-052132222819337
Pubmed

Investigation roles of Adamts1 and Adamts5 in scleral fibroblasts under hypoxia and mice with form-deprived myopia.

ADAMTS1 ADAMTS5

1.43e-052132239122105
Pubmed

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.

GRK2 GRK3

1.43e-052132233060647
Pubmed

Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study.

STAB2 STAB1

1.43e-052132233008099
Pubmed

ADAMTS proteoglycanases downregulation with impaired oocyte quality in PCOS.

ADAMTS4 ADAMTS5

1.43e-052132233444494
Pubmed

Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells.

MUC2 MUC5AC

1.43e-052132212527922
Pubmed

Exploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1- and Stabilin-2-deficient liver sinusoidal endothelial cells.

STAB2 STAB1

1.43e-052132233130055
Pubmed

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

ADAMTS4 ADAMTS5

1.43e-052132217265492
Pubmed

G protein--coupled receptor kinases.

GRK2 GRK3

1.43e-05213228035170
Pubmed

Senolytics prevent caveolar CaV 3.2-RyR axis malfunction in old vascular smooth muscle.

RYR1 CACNA1H

1.43e-052132237837625
Pubmed

Risk of non-medullary thyroid cancer influenced by polymorphic variation in the thyroglobulin gene.

TSHR TG

1.43e-052132214633662
Pubmed

Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas.

ADAMTS4 ADAMTS5

1.43e-052132216003758
Pubmed

ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.

ADAMTS4 ADAMTS5

1.43e-052132225101296
Pubmed

Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration.

ADAMTS4 ADAMTS5

1.43e-052132217978660
Pubmed

The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin.

VWF MUC2

1.43e-05213229407109
Pubmed

Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth.

ADAMTS4 ADAMTS5

1.43e-052132229926003
Pubmed

Human fibrocytes coexpress thyroglobulin and thyrotropin receptor.

TSHR TG

1.43e-052132222517745
Pubmed

ADAMTS1 and ADAMTS5 metalloproteases produced by Sertoli cells: a potential diagnostic marker in azoospermia.

ADAMTS1 ADAMTS5

1.43e-052132229737873
Pubmed

Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity.

ADAMTS4 ADAMTS5

1.43e-052132218156631
Pubmed

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.

ADAMTS4 ADAMTS5

1.43e-052132215800625
Pubmed

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.

ADAMTS4 ADAMTS5

1.43e-052132215800624
Pubmed

T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells.

CACNA1H CACNA1G

1.43e-052132222469755
Pubmed

Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis.

ADAMTS4 ADAMTS5

1.43e-052132217968948
Pubmed

ADAMTS-4 and ADAMTS-5 expression in human temporomandibular joint discs with internal derangement, correlates with degeneration.

ADAMTS4 ADAMTS5

1.43e-052132225477257
Pubmed

Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice.

ADAMTS4 ADAMTS5

1.43e-052132217938173
Pubmed

Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors.

STAB2 STAB1

1.43e-052132221293057
Pubmed

Different distribution of Cav3.2 and Cav3.1 transcripts encoding T-type Ca(2+) channels in the embryonic heart of mice.

CACNA1H CACNA1G

1.43e-052132221079360
Pubmed

In vivo glycosylation of mucin tandem repeats.

MUC2 MUC5AC

1.43e-052132211445551
Pubmed

Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues.

STAB2 STAB1

1.43e-052132211829752
Pubmed

Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population.

ADAMTS4 ADAMTS5

1.43e-052132227706574
Pubmed

ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.

ADAMTS4 ADAMTS5

1.43e-052132217255106
Pubmed

The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.

CACNA1H CACNA1G

1.43e-052132222886848
Pubmed

Human Mob1 proteins are required for cytokinesis by controlling microtubule stability.

MOB1B MOB1A

1.43e-052132222454515
Pubmed

Role of ADAMTS1 and ADAMTS5 in male infertility.

ADAMTS1 ADAMTS5

1.43e-052132226888488
Pubmed

Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice.

CACNA1H CACNA1G

1.43e-052132229082441
Pubmed

ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.

ADAMTS4 ADAMTS5

1.43e-052132231734379
Pubmed

[Decreased mRNA expressions of T-type channel alpha1H and alpha1G in the sperm of varicocele patients and their implication].

CACNA1H CACNA1G

1.43e-052132222574369
Pubmed

Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma.

MUC2 MUC5AC

1.43e-052132214594655
Pubmed

Association of Differentially Altered Liver Fibrosis with Deposition of TGFBi in Stabilin-Deficient Mice.

STAB2 STAB1

1.43e-052132237446152
Pubmed

Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.

CACNA1H CACNA1G

1.43e-052132221438841
Pubmed

Chimeric RNA ASTN2-PAPPAas aggravates tumor progression and metastasis in human esophageal cancer.

PAPPA ASTN2

1.43e-052132233388371
Pubmed

Abnormal subcellular distribution of mature MUC2 and de novo MUC5AC mucins in adenomas of the rectum: immunohistochemical detection using non-VNTR antibodies to MUC2 and MUC5AC peptide.

MUC2 MUC5AC

1.43e-052132212820724
Pubmed

β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A.

CACNA1H CACNA1G

1.43e-052132222808078
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS4 ADAMTS1 ADAMTS5 ADAMTS15 ADAMTS14

3.95e-081995550
GeneFamilyAminopeptidases|CD molecules

ANPEP NPEPL1 LNPEP

9.06e-0517953104
GeneFamilyMOB kinase activators|STRIPAK complex

MOB1B MOB1A

5.64e-047952647
CoexpressionNABA_ECM_REGULATORS

PCSK5 ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 SULF1 ADAMTS15 PAPPA ADAMTS14

3.06e-062381309M3468
CoexpressionNABA_MATRISOME

VWA3A PCSK5 RELN VWF ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 SSPOP EYS SULF1 ADAMTS15 PAPPA ADAMTS14 MUC2 MUC5AC AGRN OTOG

3.28e-06102613018M5889
CoexpressionNABA_ECM_REGULATORS

PCSK5 ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 SULF1 ADAMTS15 PAPPA ADAMTS14

3.51e-062421309MM17062
CoexpressionGSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP

NPTX1 RASA3 TM9SF3 GRN PIGQ FEN1 SLC9B2 NIN

7.06e-061991308M5620
CoexpressionGSE14000_4H_VS_16H_LPS_DC_DN

KLHDC2 SNUPN MOB1B FEN1 MOB1A KDM4A KAT6B TEDC1

7.32e-062001308M3355
CoexpressionNABA_MATRISOME

VWA3A PCSK5 RELN VWF ADAMTS4 ADAMTS1 ADAM7 ADAMTS5 SSPOP SULF1 ADAMTS15 PAPPA ADAMTS14 MUC2 MUC5AC AGRN OTOG

1.05e-05100813017MM17056
CoexpressionNABA_ECM_GLYCOPROTEINS

VWA3A RELN VWF SSPOP EYS AGRN OTOG

5.71e-051961307M3008
CoexpressionGSE24574_BCL6_HIGH_TFH_VS_TFH_CD4_TCELL_UP

PCSK5 ANPEP WHAMM STAB1 GUCY1A2 SULF1 CACNA1H

5.90e-051971307M8337
CoexpressionGSE46606_UNSTIM_VS_CD40L_IL2_IL5_DAY1_STIMULATED_BCELL_UP

PRUNE2 KLHDC2 FRY GRK3 RBPJ SORL1 NIN

5.90e-051971307M9862
CoexpressionGSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_UP

ICOSLG WDR55 NLRP9 GRK3 PRSS53 FEN1 SORL1

6.49e-052001307M6633
CoexpressionGSE20366_EX_VIVO_VS_HOMEOSTATIC_CONVERSION_TREG_UP

MED13L NPEPL1 ACOT11 BRD9 AGRN TOP3B SEC14L1

6.49e-052001307M4313
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_top-relative-expression-ranked_1000

ADAMTS4 TM9SF3 BCAT1 THSD1 DDC BNC1 PIGA LNPEP SULF1 RBPJ MOB1A ADAMTS15 FNIP1 AGRN AGTPBP1 XPO7

3.12e-0582612616DevelopingLowerUrinaryTract_e14.5_ bladder_emap-6668_1000
CoexpressionAtlasdev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#1_top-relative-expression-ranked_1000

ARHGEF28 HECTD4 BCAT1 DDC FRY GRK3 SV2C AGTPBP1

3.83e-052111268gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k1_1000
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PCSK5 RYR1 CFAP65 LRRIQ1 CACNA1H SORL1 SEC14L1

2.51e-07144132708005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM7 TSHR GPR179 RYR1 CFAP65 LRRIQ1 SLC9B2

4.91e-07159132700a157d033627d0e65c3fbd38d652c4cf56b47f6
ToppCellPericytes-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

PRUNE2 ADAMTS4 ADAMTS1 KCNE4 GUCY1A2 ADAMTS15 CACNA1H

1.17e-061811327ff445a8e56522e57e27405184d123cf905caf8cc
ToppCellEndothelial-A-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

VWF ADAMTS4 ADAMTS1 PROKR1 SULF1 NOS1 NOTCH4

1.36e-061851327ae49c61f6ecf128fe2a958b8c75c83688da75f59
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

PCSK5 VWF ARHGEF28 ADAMTS1 FRYL NOTCH4 SEC14L1

1.46e-06187132740ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 RELN PKP4 DDC GRK3 PRSS53 ACOT11

1.51e-061881327a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCellfacs-Brain_Myeloid-Striatum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIP2B RASA3 TM9SF3 STAB1 MOB1A MED12L FHL3

1.56e-0618913276dd4ec5ce4beb856f0d2d1654e3c4676d1d63736
ToppCellfacs-Brain_Myeloid-Striatum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIP2B RASA3 TM9SF3 STAB1 MOB1A MED12L FHL3

1.56e-0618913273ae479ec7e00c57127cbe51a398329b10ca9848c
ToppCellfacs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIP2B RASA3 TM9SF3 STAB1 MOB1A MED12L FHL3

1.56e-061891327875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCellfacs-Brain_Myeloid-Striatum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIP2B RASA3 TM9SF3 STAB1 MOB1A MED12L FHL3

1.56e-06189132797ef5215d841ff366a3e3682cd9bd04100cbfde0
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

VWF ADAMTS4 ADAMTS1 GUCY1A2 CACNA1H NOTCH4 SEC14L1

1.62e-061901327a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCell10x5'v1-week_12-13-Endothelial-stroma-tip_EC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

VWF ARHGEF28 ADAMTS4 THSD1 GUCY1A2 AGRN NOTCH4

1.68e-061911327cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 RELN PKP4 DDC GRK3 PRSS53 ACOT11

1.68e-0619113273387b95a3f2445c672d407922fdce3a91eabaef8
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A RELN STAB2 ADAMTS4 STAB1 KCNE4 GUCY1A2

1.80e-0619313272483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCellLV-14._Fibroblast_III|LV / Chamber and Cluster_Paper

PCSK5 ADAMTS4 ADAMTS1 KCNE4 SLC9B2 PAPPA CACNA1G

1.86e-061941327927c26aea0147f7a4b8fb3f192de4de263f1b978
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BCAT1 RYR1 ZNF710 STAB1 GRK3 RBPJ SP140

1.92e-061951327ce8215d503cad3a9bc7d5d2be4adb57408015593
ToppCellControl-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

MED13L ZNF710 GRK3 PTPRJ AGTPBP1 SEC14L1 NIN

1.92e-061951327b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 ADAMTS4 ADAMTS1 KCNE4 SULF1 CACNA1H ADAMTS14

2.06e-061971327cfb3dc4b401800e33c82cfc3baee69dbbd16ac8c
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PCSK5 NPTX1 VWF ADAMTS1 SULF1 NOS1 NOTCH4

2.06e-061971327ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCelldroplet-Bladder-nan-24m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN VWF ADAMTS4 ADAMTS1 KCNE4 GUCY1A2 CACNA1H

2.06e-061971327488e85991c5e668afb7672942726d9295b8fc7d8
ToppCell10x5'v1-week_12-13-Endothelial-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

STAB2 VWF ARHGEF28 THSD1 GUCY1A2 AGRN NOTCH4

2.13e-061981327122215d9288533ad03562cf777e846504863df9a
ToppCell10x5'v1-week_12-13-Endothelial|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

STAB2 VWF ARHGEF28 THSD1 GUCY1A2 AGRN NOTCH4

2.13e-061981327307dd09e6bc820a148f3000f18dae7aedba4be0b
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 ADAMTS4 ADAMTS1 FRY GUCY1A2 SULF1 CACNA1H

2.28e-062001327a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

RYR1 CFAP65 LRRIQ1 CACNA1H SORL1 SEC14L1

4.37e-0614313265fb5a4ea93e5cce55d427e3b4a50a979504fad3c
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-IPC_like|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

ICOSLG NPTX1 LHX9 PRSS53 CACNA1G DKK4

5.33e-061481326a261c6d3d9cf0311c053fca66c37d39e66db6ad8
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-IPC_like-IPs_and_early_cortical_neurons|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

ICOSLG NPTX1 LHX9 PRSS53 CACNA1G DKK4

5.33e-061481326c0237ba7d4040b6a497094b362dfb8b3a97a7d06
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRUNE2 ICOSLG POLE GRN STAB1 PTPRJ

8.63e-0616113268937f6b92cb2a93ea8c4780d9200a518c3112e53
ToppCellnormal_Lung-Fibroblasts-Mesothelial_cells|Fibroblasts / Location, Cell class and cell subclass

SLC28A3 KLHL31 LHX9 BNC1 GPR75 MUC5AC

1.06e-051671326892a2dc83ab5de5a1016402f8e95d2aabf651326
ToppCelldroplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ICOSLG ANPEP SSPOP RYR1 GRK3 RBPJ

1.10e-05168132699148986aa5628f67d85258c171b254be77a071c
ToppCellmetastatic_Lymph_Node-Endothelial_cells-Lymphatic_ECs|metastatic_Lymph_Node / Location, Cell class and cell subclass

RELN STAB2 VWF ADAMTS4 ADAMTS5 THSD1

1.34e-051741326d551bc29afef071adf4c9bb80345352ec33441d8
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Shisa8_(Layer_5,_medial_posterior_cortex_(Retrosplenial_cortex_(RSG),_subiculum))-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ADAM7 KLHL31 PAPPA OTOG

1.35e-054913243eca54d2c8426e6d78a4a3b261f9a5ad786515a3
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Shisa8_(Layer_5,_medial_posterior_cortex_(Retrosplenial_cortex_(RSG),_subiculum))|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ADAM7 KLHL31 PAPPA OTOG

1.35e-054913247ea79acc4a7210c32181d4b306b07fe35f598dae
ToppCellmetastatic_Lymph_Node-Endothelial_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

RELN STAB2 VWF ADAMTS4 ADAMTS5 THSD1

1.48e-05177132671bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCell367C-Endothelial_cells-Endothelial-B_(Artery)|367C / Donor, Lineage, Cell class and subclass (all cells)

VWF ADAMTS1 FRY SV2C NOS1 NOTCH4

1.53e-051781326e1e96a0e3ff718ebf676a982bc63e8ced6984059
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BCAT1 RYR1 STAB1 GRK3 RBPJ CACNA1G

1.53e-05178132624e8c62060455159235985f456af0c5023a7f3f5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BCAT1 RYR1 STAB1 GRK3 RBPJ CACNA1G

1.53e-0517813264f1cc954d4d9b5b2b75a4cf995ba81e2ada27084
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PKP4 F11 MALRD1 ACOT11 ADAMTS15 ASTN2

1.53e-0517813264df6218b20c2f076c22346d23260964cc0d73e65
ToppCell367C-Endothelial_cells-Endothelial-B_(Artery)-|367C / Donor, Lineage, Cell class and subclass (all cells)

VWF ADAMTS1 FRY SV2C NOS1 NOTCH4

1.53e-051781326363e8b23b3834692a8a79e5fdc7b43bd3a4dab5e
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

VWF THSD1 EYS SULF1 NOS1 NOTCH4

1.53e-051781326c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 NPTX1 GRK3 ASTN2 CACNA1H NIN

1.53e-05178132630ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

PCSK5 VWF ADAMTS1 FRYL NOTCH4 SEC14L1

1.58e-0517913262a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRUNE2 PCSK5 VWF FRYL STAB1 SULF1

1.63e-05180132667c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

PRUNE2 ARHGEF28 ANPEP ALDH8A1 PAPPA ASTN2

1.63e-051801326864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 PCSK5 VWF FRYL STAB1 SULF1

1.68e-0518113264ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCellCOVID-19-Heart-EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

VWF ADAMTS4 ADAMTS1 GUCY1A2 CACNA1H NOTCH4

1.73e-051821326e67f3234165199085c793915ebb1f9bbd845e933
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRUNE2 PCSK5 VWF FRYL STAB1 SULF1

1.73e-051821326ebc812ed3f25839ea25f76b952c463d79a8325b1
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRUNE2 PCSK5 VWF FRYL STAB1 SULF1

1.73e-05182132647ff6b4002a4167412c79210651316d1342503f9
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BCAT1 RYR1 ZNF710 STAB1 GRK3 RBPJ

1.79e-051831326a97f052950429245c3231464271e1ba539863bba
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 VWF GLS2 ADAMTS5 LRRIQ1 SULF1

1.84e-051841326f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 VWF GLS2 ADAMTS5 LRRIQ1 SULF1

1.84e-0518413268bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCellCOVID-19-Endothelial_cells-Arterial_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

VWF ADAMTS1 SV2C NOS1 NOTCH4 SEC14L1

1.84e-0518413260f19494789f38ab1a420545e15e748ca7eb345c3
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS4 ADAMTS1 KCNE4 GRK3 GUCY1A2 CACNA1H

1.84e-051841326327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF USP22 STAB1 PIGQ FNIP1 SPINDOC

1.90e-05185132687151ab95530e70d61328b336518df58db584acb
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

RELN ARHGEF28 HECTD4 MED13L ZNF710 CACNA1H

1.90e-0518513261d874608aa2062024323512f68889219471b2f00
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VWA3A NPTX1 ARHGEF28 LRRIQ1 GUCY1A2 NIN

1.96e-05186132684ba666237c18189d7e7556bd92dd953af733c00
ToppCellPCW_05-06-Endothelial-Endothelial_mature-lymphatic|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

STAB2 VWF ARHGEF28 THSD1 STAB1 NOTCH4

1.96e-05186132686b218a400f9c64f92b050f00b49f09647b17437
ToppCellPCW_05-06-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

STAB2 VWF ARHGEF28 THSD1 STAB1 NOTCH4

1.96e-051861326f51c76b1c3c6c49e0ebc9a913d8413e0b6a04d80
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-2|TCGA-Kidney / Sample_Type by Project: Shred V9

ADAMTS4 THSD1 KCNE4 GUCY1A2 SULF1 FHL3

1.96e-0518613261e6526fc9e9381b7ace864588cc7bd80194338d6
ToppCellControl-Endothelial_cells-Arterial_endothelial_cells|Control / group, cell type (main and fine annotations)

VWF ADAMTS1 SULF1 NOS1 NOTCH4 SEC14L1

2.02e-05187132681affaab3fe3e1daea45ada6445e906ddd33950e
ToppCellPericytes-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

ADAMTS4 ADAMTS5 KCNE4 GUCY1A2 PAPPA CACNA1H

2.08e-051881326f16ff998393bf1954bbf10caab15173bdb104ac1
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 VWF ARHGEF28 ADAMTS1 SULF1 NOTCH4

2.08e-0518813265bc1537e079c7435196c163bff5f639ea392a33a
ToppCellfacs-Pancreas-Endocrine-24m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 RELN DDC GRK3 PRSS53 ACOT11

2.14e-051891326010fdd70e9d0e21b856306a29ff877776a480319
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS5 EYS SULF1 PAPPA ASTN2 NOS1

2.21e-051901326d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCellCOVID-19-lung-Artery_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

VWF FRYL SV2C NOS1 NOTCH4 SEC14L1

2.21e-05190132607b675befcd1d0a9c90cb17b5d22323468325d51
ToppCell21-Trachea-Endothelial|Trachea / Age, Tissue, Lineage and Cell class

MAG RELN STAB2 VWF STAB1 NOTCH4

2.21e-051901326bce09634acbc2cfd53666328e8aed8bf8835f845
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS1 BCAT1 ADAMTS5 CFAP65 CACNA1G AGRN

2.21e-051901326050d6e0546954675b6adbfecb67854b1e09739d1
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADAMTS4 RASA3 ADAMTS1 SULF1 ADAMTS15 PAPPA

2.21e-0519013260fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCell21-Trachea-Endothelial-Endothelial|Trachea / Age, Tissue, Lineage and Cell class

MAG RELN STAB2 VWF STAB1 NOTCH4

2.21e-05190132608437396a98ca9526f69c3a74bbf2929f3c68b8e
ToppCellCOPD-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

PCSK5 VWF ADAMTS1 PTPRJ SULF1 NOS1

2.27e-051911326ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 RELN DDC GRK3 PRSS53 ACOT11

2.27e-051911326a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCellControl-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

PCSK5 VWF ADAMTS1 PTPRJ SULF1 NOS1

2.34e-0519213267e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCell15-Trachea-Endothelial-Endothelial|Trachea / Age, Tissue, Lineage and Cell class

RELN VWF THSD1 STAB1 SULF1 NOS1

2.41e-0519313266ea0444fc3dc156997129387184e6418947f4b12
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 RELN CRB1 PAPPA ASTN2 NOS1

2.41e-051931326d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS5 EYS SULF1 PAPPA ASTN2 NOS1

2.41e-0519313264979862c0c16e6b4baa4c79894f1d237c861f5a5
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWF ADAMTS4 ADAMTS1 SLC9B2 NOS1 NOTCH4

2.41e-0519313261e6e2d786511cc40241197368f5df20c20b882f3
ToppCellfacs-MAT-Fat-3m-Endothelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A VWF PKP4 STAB1 FRY NOTCH4

2.41e-051931326b32533afeff1905e188becaa09079e9699722e4b
ToppCelltumor_Lung-Endothelial_cells-Stalk-like_ECs|tumor_Lung / Location, Cell class and cell subclass

VWF ADAMTS4 ADAMTS1 FRY NOS1 NOTCH4

2.41e-05193132621fec35587ffb5c0157e54a821ce3ffd3e24e536
ToppCell15-Trachea-Endothelial|Trachea / Age, Tissue, Lineage and Cell class

RELN VWF THSD1 STAB1 SULF1 NOS1

2.41e-051931326b1ebf8df2d55e2938e5a495ea68b80c4ac216dc0
ToppCellfacs-MAT-Fat-3m-Endothelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A VWF PKP4 STAB1 FRY NOTCH4

2.41e-0519313262ff573ba2c74583ed1cb071a3bbc01bb71117e5f
ToppCellfacs-MAT-Fat-3m-Endothelial-endothelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A VWF PKP4 STAB1 FRY NOTCH4

2.41e-051931326e164f6403a8b541ced08a6feec915d2e855036ea
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 RELN EYS PAPPA ASTN2 NOS1

2.41e-051931326e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 RELN EYS PAPPA ASTN2 NOS1

2.41e-051931326658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADAMTS4 ADAMTS1 ADAMTS5 SULF1 ADAMTS15 PAPPA

2.41e-051931326261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCellCOVID-19-Heart-Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

BCAT1 ZNF710 STAB1 GRK3 PTPRJ RBPJ

2.48e-051941326f09675cd472200363c458952f00d2e41990800ee
ToppCell5'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Paneth|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 ANPEP SLC28A3 DDC MALRD1 MUC2

2.48e-0519413262f6e62a4ec8707bd5a16c0734c5131af55207ea2
ToppCellnucseq-Immune-Immune_Myeloid-pMON-pMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ZNF710 GRK2 GRK3 PTPRJ SEC14L1 NIN

2.48e-051941326e237384b02be460d44eeada3026a5691c66f6fc1
ToppCellnucseq-Immune-Immune_Myeloid-pMON|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ZNF710 GRK2 GRK3 PTPRJ SEC14L1 NIN

2.48e-0519413260bc83ae79873a5e473e6e1e3111924cd003986a1
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS5 EYS SULF1 PAPPA ASTN2 NOS1

2.48e-051941326e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BCAT1 RYR1 ZNF710 STAB1 GRK3 RBPJ

2.48e-0519413261dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 RELN EYS PAPPA ASTN2 NOS1

2.48e-0519413261bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAMTS1 ALDH8A1 SLC28A3 BNC1 SULF1 PAPPA

2.48e-051941326421344cc4b601d9745fa72d0af3124dab11d1d27
ToppCellRA-08._Macrophage|RA / Chamber and Cluster_Paper

ANPEP BCAT1 ZNF710 STAB1 TG RBPJ

2.48e-051941326ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCellCOVID-19-lung-Pericytes/_Smooth_Muscle|lung / Disease (COVID-19 only), tissue and cell type

PRUNE2 ADAMTS4 ADAMTS1 FRY GUCY1A2 CACNA1H

2.48e-0519413265e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

VWF ADAMTS4 ADAMTS1 SULF1 NOTCH4 SEC14L1

2.55e-051951326fde8e7b38b3631109b95ef111c5f6e3f9878cfbd
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 DDC GRK3 PRSS53 ACOT11 SEC14L1

2.55e-051951326bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellControl-Myeloid-ncMonocyte|Control / Disease state, Lineage and Cell class

MED13L GRK3 PTPRJ AGTPBP1 SEC14L1 NIN

2.55e-051951326fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCellEndothelial-A-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

VWF ADAMTS4 ADAMTS1 SLC9B2 NOS1 NOTCH4

2.55e-051951326c3a0aa34b672c99cb3a2a4e9218412dbd19da3ca
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BCAT1 RYR1 ZNF710 STAB1 GRK3 RBPJ

2.55e-051951326247803cf58c6d9c561a52aa34e581188ddad197e
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN FRYL DDC GRK3 PRSS53 FNIP1

2.55e-0519513263e519cffa6144a62b06124642a14c9ff39b76554
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BCAT1 RYR1 ZNF710 STAB1 GRK3 RBPJ

2.55e-05195132609df40ff9b493170861b3f6e57a942a834655b5c
Diseasebipolar disorder (is_marker_for)

RELN VWF GRN GRK3

1.13e-06191254DOID:3312 (is_marker_for)
Diseasevenous thromboembolism, fibrinogen measurement

DIP2B VWF HECTD4 F11 PTPRJ

9.85e-06671255EFO_0004286, EFO_0004623
Diseasefactor VIII measurement, venous thromboembolism

STAB2 VWF F11 PTPRJ

1.29e-05341254EFO_0004286, EFO_0004630
Diseasecystitis (is_marker_for)

MUC2 MUC5AC

1.78e-0521252DOID:1679 (is_marker_for)
Diseasemood disorder

RELN SV2C SORL1

2.06e-05131253EFO_0004247
Diseasebody weight

RALGAPA1 PCSK5 RELN HECTD4 CAST SLC28A3 SNUPN CRB1 EYS KCNE4 PTPRJ FNIP1 PAPPA ASTN2 ADAMTS14 KAT6B XPO7

2.43e-05126112517EFO_0004338
Diseasevenous thromboembolism, von Willebrand factor measurement

STAB2 VWF F11 PTPRJ

3.03e-05421254EFO_0004286, EFO_0004629
Diseasesputum mucin-5B amount

MUC2 MUC5AC

5.33e-0531252OBA_2050332
DiseaseCongenital myasthenic syndrome ib

GRN AGRN

5.33e-0531252C1850792
Diseasea disintegrin and metalloproteinase with thrombospondin motifs 5 measurement

ADAMTS1 ADAMTS5

5.33e-0531252EFO_0008326
Diseasefactor VIII measurement, Ischemic stroke

STAB2 VWF HECTD4

6.84e-05191253EFO_0004630, HP_0002140
Diseasefactor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement

DIP2B HECTD4 F11 FNIP1

9.51e-05561254EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
DiseaseAutoimmune thyroiditis

TSHR TG

1.06e-0441252C0920350
DiseaseMultiple congenital anomalies-hypotonia-seizures syndrome

PIGQ PIGA

1.06e-0441252cv:C5191419
Diseasemucinous adenocarcinoma (is_marker_for)

MUC2 MUC5AC

1.77e-0451252DOID:3030 (is_marker_for)
Diseaseprimary progressive multiple sclerosis (is_implicated_in)

GRN ADAMTS14

1.77e-0451252DOID:0050784 (is_implicated_in)
Diseaseretinitis pigmentosa (implicated_via_orthology)

CRB1 EYS AGTPBP1

2.02e-04271253DOID:10584 (implicated_via_orthology)
Diseaserheumatoid arthritis (is_marker_for)

ADAMTS4 ADAMTS5 GRK2 NOTCH4

2.14e-04691254DOID:7148 (is_marker_for)
DiseaseParkinson's disease (biomarker_via_orthology)

DDC GRK2 GRK3

2.77e-04301253DOID:14330 (biomarker_via_orthology)
Diseasefactor XI measurement, venous thromboembolism

VWF F11 PTPRJ

2.77e-04301253EFO_0004286, EFO_0004694
DiseaseIschemic stroke, von Willebrand factor measurement

STAB2 VWF HECTD4

2.77e-04301253EFO_0004629, HP_0002140
Diseasemigraine disorder, glucose measurement

SLC28A3 CACNA1H KDM4A

3.06e-04311253EFO_0004468, MONDO_0005277
Diseaseeye morphology measurement

RASA3 FRY GUCY1A2 PTPRJ PAPPA ASTN2

3.43e-042181256EFO_0007858
Diseaseendoplasmic reticulum aminopeptidase 1 measurement

CAST LNPEP

3.69e-0471252EFO_0008119
Diseaselupus nephritis

CRB1 NOTCH4 NIN

3.69e-04331253EFO_0005761
DiseaseNerve Degeneration

GRN DDC NOS1 AGTPBP1

4.35e-04831254C0027746
Diseasethyroid stimulating hormone measurement

AEN RASA3 TSHR TG FRY PTPRJ SULF1

4.67e-043231257EFO_0004748
Diseasevenous thromboembolism, factor VII measurement

VWF F11 PTPRJ

5.62e-04381253EFO_0004286, EFO_0004619
Diseasebringing up phlegm, sputum or mucus on most days, self-reported

MUC2 MUC5AC

6.29e-0491252EFO_0009824
Diseaseglioblastoma (implicated_via_orthology)

USP22 POLE

6.29e-0491252DOID:3068 (implicated_via_orthology)
DiseaseMelancholia

RELN TG NOS1

7.03e-04411253C0025193
DiseaseDepression, Neurotic

RELN TG NOS1

7.03e-04411253C0282126
DiseaseDepressive Syndrome

RELN TG NOS1

7.55e-04421253C0086133
Diseaseage at onset, multiple sclerosis

PCSK5 RELN

7.84e-04101252EFO_0004847, MONDO_0005301
Diseasefibrinogen measurement, tissue plasminogen activator measurement

DIP2B HECTD4 FNIP1

9.25e-04451253EFO_0004623, EFO_0004791
Diseasefibrinogen measurement, plasminogen activator inhibitor 1 measurement

DIP2B HECTD4 FNIP1

9.25e-04451253EFO_0004623, EFO_0004792
Diseasehemopexin measurement

CRB1 LHX9

9.55e-04111252EFO_0008149
Diseasedegenerative disc disease (biomarker_via_orthology)

ADAMTS4 ADAMTS5

9.55e-04111252DOID:90 (biomarker_via_orthology)
Diseaseserum albumin measurement

GLS2 RASA3 SLC28A3 AAGAB FRY PTPRJ RBPJ NOTCH4 TEDC1

9.66e-045921259EFO_0004535
DiseaseEndogenous depression

RELN TG NOS1

9.86e-04461253C0011573
DiseaseBipolar Disorder

RELN GRN DDC STAB1 GRK3 ASTN2 DKK4 NOTCH4

9.95e-044771258C0005586
DiseaseBehavior Disorders

DDC NOS1

1.14e-03121252C0004930
DiseaseMental disorders

DDC NOS1

1.14e-03121252C0004936
DiseaseMental Disorders, Severe

DDC NOS1

1.14e-03121252C4046029
Diseasedementia (is_implicated_in)

GRN NOTCH4

1.14e-03121252DOID:1307 (is_implicated_in)
DiseaseDiagnosis, Psychiatric

DDC NOS1

1.14e-03121252C0376338
Diseaseautistic disorder (is_marker_for)

RELN GRN

1.14e-03121252DOID:12849 (is_marker_for)
DiseaseCongenital Hypothyroidism

TSHR TG

1.35e-03131252C0010308
Diseasecongenital hypothyroidism (implicated_via_orthology)

TSHR TG

1.57e-03141252DOID:0050328 (implicated_via_orthology)
Diseaseeosinophil count

DIP2B ICOSLG ADAMTS4 TMEM116 HECTD4 AAGAB TG PTPRJ MED12L FNIP1 CACNA1H MUC2 MUC5AC NOTCH4 SP140

1.60e-03148812515EFO_0004842
Diseaseamyotrophic lateral sclerosis, age at onset

PCSK5 KDM4A

1.80e-03151252EFO_0004847, MONDO_0004976
Diseaseimpotence (implicated_via_orthology)

GRK2 NOS1

1.80e-03151252DOID:1875 (implicated_via_orthology)
Diseaseadverse effect, response to xenobiotic stimulus

STAB2 GLS2 ASTN2

2.03e-03591253EFO_0009658, GO_0009410
Diseasetelomere length

ARHGEF28 CAST SLC28A3 MOB1B CACNA1H SENP7

2.22e-033131256EFO_0004505
DiseaseMuscle hypotonia

RALGAPA1 DDC

2.32e-03171252C0026827
Diseasefactor XI measurement, Ischemic stroke

HECTD4 F11

2.32e-03171252EFO_0004694, HP_0002140
Diseasecystic fibrosis (is_marker_for)

MUC2 NOS1 MUC5AC

2.34e-03621253DOID:1485 (is_marker_for)
Diseasecaudal middle frontal gyrus volume measurement

FRY ASTN2

2.61e-03181252EFO_0010290
Diseaseacute lymphoblastic leukemia

DDC KCNE4 PTPRJ

2.80e-03661253EFO_0000220
Diseasecarotid artery disease (is_marker_for)

VWF PAPPA

2.90e-03191252DOID:3407 (is_marker_for)
DiseaseCannabis use, age at onset

CAST SLC28A3

2.90e-03191252EFO_0004847, EFO_0007585
DiseaseParkinson's disease (is_marker_for)

CAST GRN NOS1

2.92e-03671253DOID:14330 (is_marker_for)
DiseaseVertigo

MALRD1 SLC10A5 MED12L OTOG

2.94e-031391254HP_0002321
Diseasebiological sex

PKP4 SLC28A3 PTPRJ AGTPBP1 XPO7

3.03e-032301255PATO_0000047
Diseasevenous thromboembolism

RELN VWF ARHGEF28 F11 PTPRJ SV2C ASTN2

3.53e-034601257EFO_0004286
Diseasevenous thromboembolism, plasminogen activator inhibitor 1 measurement

VWF F11

3.55e-03211252EFO_0004286, EFO_0004792
Diseasegamma-glutamylglutamine measurement

GLS2 ASTN2

3.89e-03221252EFO_0021138
Diseaseportal hypertension (biomarker_via_orthology)

DDC GRK2

3.89e-03221252DOID:10762 (biomarker_via_orthology)
DiseaseParkinson's disease (is_implicated_in)

CAST DDC NOS1

4.17e-03761253DOID:14330 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
GPSVLSDETMAAICC

PKP4

926

Q99569
LPSKCVAIDCEMVGT

AEN

106

Q8WTP8
CAAVMRVALSSCVPD

FAM200B

631

P0CF97
MAVTCDPEAFLSICF

BTNL10

1

A8MVZ5
CCMTEEIFGPVTCVV

ALDH8A1

386

Q9H2A2
LPCGTCDMVFRSSAL

CCDC17

11

Q96LX7
VSTGDCPFIVCMTYA

GRK3

246

P35626
REMFGSGTACVVCPV

BCAT1

326

P54687
VISCMFEPEGNACSL

BRD9

276

Q9H8M2
TCPSGKCVMDSDGSI

ADAM7

351

Q9H2U9
CDTLGMADVGTICSP

ADAMTS5

376

Q9UNA0
MADVGTICSPERSCA

ADAMTS5

381

Q9UNA0
FECPDFSTCCVMVDG

GRN

131

P28799
SAPATCAEMRCEFGA

AGRN

896

O00468
EMHTCTVEGCNATFP

BNC1

746

Q01954
PVMCTECSTEVAVYD

EAPP

256

Q56P03
GCPCVTASMDDIYFE

ACOT11

86

Q8WXI4
FSVDMTCGGCAEAVS

ATOX1

6

O00244
CSNGVPECEEMVSGL

ANPEP

761

P15144
PFFMVATLGTTTCCS

DDC

236

P20711
PAFCMSSCSFVVEKS

AGTPBP1

1066

Q9UPW5
ATSSTIFMFCGCVEE

ASTN2

726

O75129
EPCTGDRSVFCQMEV

ADAMTS14

1061

Q8WXS8
LCGATTCDTLGMADV

ADAMTS15

321

Q8TE58
TSCFCMTEPDVASSD

ACAD11

501

Q709F0
VSTGDCPFIVCMSYA

GRK2

246

P25098
FFCDVPAMLTLACTD

OR2L2

176

Q8NH16
GIVENMSGFTCPHCT

NUBP2

186

Q9Y5Y2
ITESGVSCPTVMCDI

RASA3

441

Q14644
VSCPTVMCDIFFSLR

RASA3

446

Q14644
TCDTLGMADVGTVCD

ADAMTS1

366

Q9UHI8
GMADVGTVCDPSRSC

ADAMTS1

371

Q9UHI8
PEVLMDCGVDLTASC

KAT6B

1471

Q8WYB5
ICTSVPVDADMCAAS

NPTX1

31

Q15818
ICDSSPMLLIACTDT

OR6C65

176

A6NJZ3
SVCLCSEGYSPVTMG

ARHGEF28

71

Q8N1W1
DCMFPSRCSGVEHFI

POGLUT1

101

Q8NBL1
CTDPASMASFDCEVV

PTPRJ

716

Q12913
GSTECVLPAVMSCDR

OR2G2

111

Q8NGZ5
APALSCTLCSMEGDS

KCNE4

161

Q8WWG9
PEATVGVSCCTLSMP

KLHL31

601

Q9H511
TCDVITCEPMGSLID

MED12L

1631

Q86YW9
VCRMCGISAADSPSI

MED13L

1931

Q71F56
AGTEVEVSCMVPDNC

MAG

151

P20916
SNDVMCICSPIFTDL

EYS

351

Q5T1H1
EGCTSCMDATPCLVE

GPR179

361

Q6PRD1
RTVDYCSIMPSGCAS

CFAP65

436

Q6ZU64
EDCTTCPMTRIFDDG

PCSK5

901

Q92824
MEIVGCRAEDNSCPF

LHX9

1

Q9NQ69
FFCDVPAMLTLACTD

OR2L5

176

Q8NG80
FCDIPAVMVLSCSDR

OR5B3

176

Q8NH48
ACVFDSCFMPGSSLE

MUC2

4716

Q02817
IVMVCEQPEVFASAC

NPEPL1

111

Q8NDH3
AMSAVLCCGPVADNV

FRYL

1111

O94915
MLCSECPTVFVDAET

FRYL

2751

O94915
CPTVFVDAETLMSCG

FRYL

2756

O94915
AICPCATSAEAMTVA

DIP2B

666

Q9P265
IPEMCFTSTGCSTDI

KDM4A

706

O75164
QCSCGESTVTFSMDP

KDM4E

306

B2RXH2
GACSVPSARTMVVCA

LNPEP

101

Q9UIQ6
CSVEVTCESGSVMAA

GLS2

351

Q9UI32
TDFCTEESCPVMSAG

MOB1B

76

Q7L9L4
TEGCFCPEGMTLFST

MUC5AC

5251

P98088
CPEGMTLFSTSAQVC

MUC5AC

5256

P98088
QPSAMVDEATCAACD

POLE

641

Q07864
GISEIQSCSDPCMET

PAPPA

576

Q13219
QSCSDPCMETEPSFE

PAPPA

581

Q13219
PCCRFTYLTMTGEEV

HECTD4

3786

Q9Y4D8
LSFCDLFICGVTAPM

GPR75

86

O95800
QFEIDDSSPSMSGCC

NAA40

191

Q86UY6
EPDSMTCCVSESTLL

LRRIQ1

721

Q96JM4
ECLPSMPSCQEFTSA

RELN

966

P78509
TLETGCTEYICMGSI

NOS1

326

P29475
RAMVGSDVELSCACP

ICOSLG

26

O75144
NTDLSLEDSPMCVVC

SCYL3

431

Q8IZE3
LCSNMEFPCSTDECI

MALRD1

1946

Q5VYJ5
TCDTLGMADVGTVCD

ADAMTS4

326

O75173
GMADVGTVCDPARSC

ADAMTS4

331

O75173
AFSSQCSACGETVMP

FHL3

96

Q13643
ATEDMDCLTFGSPVL

FEN1

176

P39748
VTLGMFRPCEDIACD

CACNA1G

96

O43497
PGTLCVNDVCTTMED

DKK4

81

Q9UBT3
LGISDECQMISPSDC

FNIP1

641

Q8TF40
DSVMAPDAFVCGRIC

F11

216

P03951
APVSEAVCRTSMCSI

CAST

401

P20810
DVPPSMSGSCAVCVD

KLHDC2

86

Q9Y2U9
AMSAVLCCGPVFDNV

FRY

1161

Q5TBA9
MLTSCSECPTLFVDA

FRY

2746

Q5TBA9
SGFTGTHCETLMPLC

CRB1

291

P82279
TLGMFRPCEDVECGS

CACNA1H

116

O95180
GGTPDIASCCEIMEE

CDKN3

111

Q16667
EIIPDFLSGECMCEV

SEC14L1

481

Q92503
MNPICSRCEEGFVTG

RYR1

201

P21817
QACSVLTGEMFAPCS

OTOG

711

Q6ZRI0
DIVGFTAICAQCTPM

GUCY1A2

526

P33402
DPMTGTFRCTFCHTE

GTF2E1

146

P29083
STCSFPAGVAVAEEM

SENP7

681

Q9BQF6
VSSSVLPSGDLMCDC

SORL1

1046

Q92673
CALPCVSSVVALTFM

SV2C

326

Q496J9
LSACMGPEVESSELC

PRUNE2

2121

Q8WUY3
TCAQGEEMVLEPGSC

SSPOP

5026

A2VEC9
GLVMSSCLDEPATEF

NIN

1101

Q8N4C6
TEFCTEASCPVMSAG

MOB1A

76

Q9H8S9
MVLKAFFPTCCVSTD

PIGQ

1

Q9BRB3
RLSMGPCIVEACTSA

SLC9B2

206

Q86UD5
CMVCGAEIRAPSADT

SPINDOC

91

Q9BUA3
ELSCMEGSCTCSFPT

RNF216

556

Q9NWF9
ADEPMTTFVVCNECG

TCEA1

281

P23193
LESFSCPGSMDEVLA

WHAMM

701

Q8TF30
IAGTVACFMTACIAG

SLC28A3

596

Q9HAS3
PCTPESLCDVLSMDF

SNUPN

236

O95149
LPEAQAFGVVMTCTC

SLC10A5

201

Q5PT55
ASVAPFTVAMCSGCE

SLC10A5

396

Q5PT55
DGVTPLMSAVCCGEV

NOTCH4

1586

Q99466
LMSAVCCGEVQSGTF

NOTCH4

1591

Q99466
MAAGVPCALVTSCSS

AAGAB

1

Q6PD74
MCVENIFPDDSGCIS

NLRP9

596

Q7RTR0
TEAFCMAIVEAASCG

PIGA

311

P37287
ISDFLVAIVCCPFEM

PROKR1

106

Q8TCW9
GMVCTSAVGELPSCE

PRSS53

461

Q2L4Q9
TDTDICNAMACLGEP

TOP3B

156

O95985
GTMVCAFLIASEICS

TPTE

346

P56180
CPVSEMFGRLCPVSE

nan

116

Q6ZQT0
PSSCLVCEMSSLFQE

USP22

216

Q9UPT9
EISEFPSECCSVMAG

RALGAPA1

1036

Q6GYQ0
KVMLEGSCVPEEACT

VWF

2241

P04275
VCPGMSLEASLCSLE

THSD1

376

Q9NS62
GDEMTVCQCEALASP

TEDC1

136

Q86SX3
LMTPVFCLGNTSECF

TMEM116

36

Q8NCL8
RPFVCTECGMEFSQI

ZNF710

461

Q8N1W2
VGTMVTCTCLPDYEG

STAB1

2111

Q9NY15
DGTLCSEMDPCTGLT

STAB2

861

Q8WWQ8
MAALFQEASSCPVCS

RFPL2

91

O75678
RCGESMLCVVPDISA

RBPJ

396

Q06330
VASIMDAPTICPDCG

ZNF697

181

Q5TEC3
EKPYMCSECGETFSV

ZNF697

406

Q5TEC3
ASRAIPFGTMVAVCC

TM9SF3

386

Q9HD45
CCLFHESGMPFTSSE

ZNF416

161

Q9BWM5
IVGAMFSCTECLIES

TIMM22

131

Q9Y584
IDCMVPVTESLLCTG

WDR55

256

Q9H6Y2
SEGLTALDTMVCTGC

XPO7

921

Q9UIA9
CVMCFSEEVPGSPEA

SP140

456

Q13342
TFINAFVTTPMCCPS

SULF1

76

Q8IWU6
SEFPVMQCLTDCTED

TG

1596

P01266
SPCEALTCTMEEIST

VWA3A

361

A6NCI4
DYTICGDSEDMVCTP

TSHR

386

P16473