Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	nuclear protein-containing complex	BRD8 MTA1 RGPD8 ACTR5 BAZ2A SUPT6H SF3B6 BAZ1B CSTF3 DKC1 SIN3A MVP BAHD1 TENT2 NUP153 NUP205 RGPD5	2.39e-05	1377	83	17	GO:0140513
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	BRD8 MTA1 ACTR5 BAZ2A BAZ1B	4.02e-05	96	83	5	GO:0070603
GeneOntologyCellularComponent	nuclear pore	RGPD8 MVP NUP153 NUP205 RGPD5	5.13e-05	101	83	5	GO:0005643
GeneOntologyCellularComponent	ATPase complex	BRD8 MTA1 ACTR5 BAZ2A BAZ1B	1.64e-04	129	83	5	GO:1904949
Domain	BROMODOMAIN_1	BRD8 BAZ2A ATAD2B BAZ1B	1.94e-05	37	81	4	PS00633
Domain	Bromodomain	BRD8 BAZ2A ATAD2B BAZ1B	2.17e-05	38	81	4	PF00439
Domain	BROMODOMAIN_2	BRD8 BAZ2A ATAD2B BAZ1B	2.94e-05	41	81	4	PS50014
Domain	BROMO	BRD8 BAZ2A ATAD2B BAZ1B	3.24e-05	42	81	4	SM00297
Domain	Bromodomain	BRD8 BAZ2A ATAD2B BAZ1B	3.24e-05	42	81	4	IPR001487
Domain	-	BRD8 BAZ2A ATAD2B BAZ1B	3.24e-05	42	81	4	1.20.920.10
Domain	DDT	BAZ2A BAZ1B	1.84e-04	5	81	2	SM00571
Domain	WSD	BAZ2A BAZ1B	1.84e-04	5	81	2	PF15613
Domain	WHIM1	BAZ2A BAZ1B	1.84e-04	5	81	2	PF15612
Domain	DDT_dom	BAZ2A BAZ1B	1.84e-04	5	81	2	IPR018501
Domain	WHIM1_dom	BAZ2A BAZ1B	1.84e-04	5	81	2	IPR028942
Domain	WHIM2_dom	BAZ2A BAZ1B	1.84e-04	5	81	2	IPR028941
Domain	Bromodomain_CS	BAZ2A ATAD2B BAZ1B	1.90e-04	26	81	3	IPR018359
Domain	DDT	BAZ2A BAZ1B	2.76e-04	6	81	2	PS50827
Domain	BAH	MTA1 BAHD1	9.96e-04	11	81	2	SM00439
Domain	Grip	RGPD8 RGPD5	9.96e-04	11	81	2	SM00755
Domain	BAH	MTA1 BAHD1	9.96e-04	11	81	2	PF01426
Domain	BAH	MTA1 BAHD1	9.96e-04	11	81	2	PS51038
Domain	GRIP	RGPD8 RGPD5	9.96e-04	11	81	2	PF01465
Domain	BAH_dom	MTA1 BAHD1	9.96e-04	11	81	2	IPR001025
Domain	Ran_BP1	RGPD8 RGPD5	1.19e-03	12	81	2	PF00638
Domain	GRIP_dom	RGPD8 RGPD5	1.19e-03	12	81	2	IPR000237
Domain	GRIP	RGPD8 RGPD5	1.19e-03	12	81	2	PS50913
Domain	RANBD1	RGPD8 RGPD5	1.19e-03	12	81	2	PS50196
Domain	RanBD	RGPD8 RGPD5	1.40e-03	13	81	2	SM00160
Domain	Ran_bind_dom	RGPD8 RGPD5	1.40e-03	13	81	2	IPR000156
Domain	uDENN	DENND2A DENND2B	1.63e-03	14	81	2	SM00800
Domain	uDENN	DENND2A DENND2B	1.88e-03	15	81	2	PF03456
Domain	UDENN	DENND2A DENND2B	2.14e-03	16	81	2	PS50946
Domain	DDENN	DENND2A DENND2B	2.14e-03	16	81	2	PS50947
Domain	DENN	DENND2A DENND2B	2.14e-03	16	81	2	SM00799
Domain	dDENN	DENND2A DENND2B	2.14e-03	16	81	2	SM00801
Domain	DENN	DENND2A DENND2B	2.14e-03	16	81	2	PF02141
Domain	dDENN_dom	DENND2A DENND2B	2.14e-03	16	81	2	IPR005112
Domain	uDENN_dom	DENND2A DENND2B	2.14e-03	16	81	2	IPR005113
Domain	dDENN	DENND2A DENND2B	2.14e-03	16	81	2	PF03455
Domain	DENN	DENND2A DENND2B	2.14e-03	16	81	2	PS50211
Domain	DENN_dom	DENND2A DENND2B	2.14e-03	16	81	2	IPR001194
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	GTF3C1 BAZ2A ZNF644 SF3B6 WDR46 TCF25 BAZ1B SIN3A DDX27 NUP153 NUP205	5.90e-10	341	83	11	32971831
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	GTF3C1 BAZ2A SUPT6H ATAD2B WDR46 HELZ2 MAK16 BAZ1B MVP DDX27 RPL7A NUP153 NUP205	5.08e-09	653	83	13	22586326
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	RGPD8 BAZ2A WDR46 HELZ2 MAK16 BAZ1B DKC1 DDX27 NUP153 NUP205	7.21e-09	332	83	10	25693804
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BRD8 MTA1 GTF3C1 BAZ2A ZNF644 HELZ2 BAZ1B DKC1 SIN3A NUP153 PPL PHLDB2	3.10e-07	774	83	12	15302935
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	DNAJB12 BRD8 MTA1 ACTR5 BAZ2A SUPT6H SF3B6 HELZ2 APC MAK16 BAZ1B CSTF3 FBXO11 MAGT1 DDX27 GGCX	4.34e-07	1497	83	16	31527615
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	NPR1 BRD8 GTF3C1 RGPD8 ZNF644 SF3B6 APC DKC1 IDE KIF24 NUP153 PPL KIF1C RGPD5	5.74e-07	1155	83	14	20360068
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	BRD8 MTA1 BAZ2A ATAD2B BAZ1B	1.04e-06	75	83	5	25593309
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	SUPT6H SF3B6 MAK16 BAZ1B CSTF3 DKC1 RPL7A NUP205	1.60e-06	340	83	8	29478914
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	BRD8 MTA1 GTF3C1 BAZ2A SUPT6H SIN3A	1.67e-06	150	83	6	28242625
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	MTA1 BAZ2A WDR46 MAK16 BAZ1B DKC1 DDX27 NUP153	1.95e-06	349	83	8	25665578
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	BRD8 MTA1 GTF3C1 ACTR5 BAZ2A SUPT6H ZNF644 BAZ1B DKC1 FBXO11 SIN3A MAGT1 RPL7A NUP153	2.18e-06	1294	83	14	30804502
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	BRD8 MTA1 GTF3C1 APC PAN2 DKC1 NUP153 PHLDB2 KIF1C	3.28e-06	503	83	9	16964243
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	GTF3C1 SUPT6H SF3B6 WDR46 MAK16 BAZ1B DKC1 SIN3A DDX27 RPL7A NUP153 NUP205	3.96e-06	989	83	12	36424410
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	MTA1 BAZ2A ZNF644 BAZ1B DKC1	4.99e-06	103	83	5	32744500
Pubmed	Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB.	CDHR3 GSDMB	5.63e-06	2	83	2	35381269
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	GTF3C1 SUPT6H SF3B6 WDR46 BAZ1B CSTF3 DKC1 DDX27 RPL7A NUP153 PHLDB2 NUP205	5.64e-06	1024	83	12	24711643
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PALS1 GTF3C1 HELZ2 MAK16 BAZ1B MAGT1 MVP DDX27 RPL7A NUP153 PPL PHLDB2 NUP205	8.52e-06	1257	83	13	36526897
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	GTF3C1 SUPT6H SF3B6 HELZ2 APC PAN2 CSTF3 DKC1 FBXO11 MVP RPL7A NUP205	9.81e-06	1082	83	12	38697112
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	BRD8 MTA1 ACTR5 BAZ2A TCF25 BAZ1B SIN3A ACY1 MAST2 TENT2 GGCX PHLDB2	1.34e-05	1116	83	12	31753913
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	GTF3C1 MAK16 TCF25 BAZ1B DKC1 FBXO11 SIN3A DDX27 RPL7A NUP205	1.34e-05	759	83	10	35915203
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	GTF3C1 TCF25 BAZ1B DKC1 EIF2AK4 MAGT1 MVP RPL7A KIF1C	1.37e-05	601	83	9	33658012
Pubmed	Rhinovirus in the Pathogenesis and Clinical Course of Asthma.	CDHR3 GSDMB	1.69e-05	3	83	2	26270739
Pubmed	FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase.	SLC27A1 RPE65	1.69e-05	3	83	2	20356843
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	ACOD1 DNAJB12 MTA1 GTF3C1 TCF25 BAZ1B CSTF3 MAGT1 DDX27 RPL7A NUP153	1.96e-05	971	83	11	33306668
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	PALS1 TCAF1 SUPT6H APC PAN2 DKC1 FBXO11 EIF2AK4 NUP153 NUP205 RGPD5	2.69e-05	1005	83	11	19615732
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	BRD8 MTA1 RGPD8 SUPT6H SIN3A	2.72e-05	146	83	5	23892456
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DNAJB12 BRD8 MTA1 GTF3C1 SUPT6H BAZ1B CSTF3 DKC1 SIN3A NUP153 NUP205	2.91e-05	1014	83	11	32416067
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	GTF3C1 HELZ2 APC DKC1 NUP153 NUP205	3.09e-05	250	83	6	33536335
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	MTA1 BAZ2A SUPT6H SF3B6 BAZ1B RPL7A	3.16e-05	251	83	6	28077445
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	GTF3C1 SUPT6H WDR46 MAK16 BAZ1B CSTF3 DKC1 IDE MAST2 DDX27 RPL7A NUP153 NUP205	3.18e-05	1425	83	13	30948266
Pubmed	The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription.	BAZ2A SIN3A	3.37e-05	4	83	2	12198165
Pubmed	Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.	RGPD8 RGPD5	3.37e-05	4	83	2	9480752
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	DYNLT2B BRD8 MTA1 SKIDA1 CEP41 BAZ1B OAS1 IDE CFAP61 MAST2 KIF24 DDX27	3.81e-05	1242	83	12	30973865
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	TCAF1 GTF3C1 ACTR5 DKC1 SIN3A DDX27 NUP153	4.50e-05	394	83	7	27248496
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	PALS1 BRD8 GTF3C1 BAZ2A BAZ1B SIN3A TP53BP2 RGPD5	5.12e-05	549	83	8	38280479
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TCAF1 BRD8 MTA1 TMEM106C APC PAN2 BAZ1B OAS1 FBXO11 EIF2AK4 NUP153	5.33e-05	1084	83	11	11544199
Pubmed	CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium.	PALS1 RPE65	5.60e-05	5	83	2	26404741
Pubmed	Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin.	CHRNB1 KIF1C	5.60e-05	5	83	2	16429160
Pubmed	Generation and Validation of miR-142 Knock Out Mice.	TSPOAP1 APC	5.60e-05	5	83	2	26327117
Pubmed	A novel family of bromodomain genes.	BAZ2A BAZ1B	5.60e-05	5	83	2	10662543
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	GTF3C1 ACTR5 BAZ2A WDR46 CEP41 MAK16 DDX27	5.78e-05	410	83	7	26949251
Pubmed	Nucleolar proteome dynamics.	SF3B6 WDR46 MAK16 BAZ1B DKC1 DDX27 RPL7A	6.62e-05	419	83	7	15635413
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	BAZ2A SF3B6 WDR46 MAK16 BAZ1B DKC1 MAGT1 DDX27 RPL7A TENT2 NUP153 NUP205	6.73e-05	1318	83	12	30463901
Pubmed	The functional interactome landscape of the human histone deacetylase family.	MTA1 BAZ1B DKC1 SIN3A DDX27 NUP153	6.90e-05	289	83	6	23752268
Pubmed	FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis.	FBXO11 BAHD1	8.39e-05	6	83	2	33156908
Pubmed	Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket.	NUP153 NUP205	8.39e-05	6	83	2	15229283
Pubmed	A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.	CDHR3 GSDMB	8.39e-05	6	83	2	24241537
Pubmed	WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.	BAZ2A BAZ1B	8.39e-05	6	83	2	11980720
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	TCAF1 BRD8 ACTR5 DKC1 RPL7A KIF1C	8.47e-05	300	83	6	28561026
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	GTF3C1 BAZ2A SF3B6 WDR46 BAZ1B DKC1 MVP DDX27 RPL7A PHLDB2 TP53BP2 NUP205	8.64e-05	1353	83	12	29467282
Pubmed	Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.	PALS1 PDZD7 MAST2	8.84e-05	36	83	3	26053890
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	GTF3C1 SUPT6H APC DKC1 DDX27 NUP153 NUP205	8.98e-05	440	83	7	34244565
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	TCAF1 MAN2A2 SF3B6 HELZ2 MAK16 DKC1 FBXO11 EIF2AK4 MAGT1 DDX27 GGCX NUP205	9.78e-05	1371	83	12	36244648
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	MTA1 BAZ1B SIN3A NUP153 NUP205	1.07e-04	195	83	5	19454010
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD8 RGPD5	1.17e-04	7	83	2	15710750
Pubmed	Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex.	NUP153 NUP205	1.17e-04	7	83	2	12802065
Pubmed	BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk.	NPR1 NMB	1.17e-04	7	83	2	34919054
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	DNAJB12 SUPT6H CSTF3 DKC1 SIN3A RPL7A NUP153 NUP205	1.45e-04	638	83	8	33239621
Pubmed	Directed proteomic analysis of the human nucleolus.	WDR46 MAK16 DKC1 DDX27 RPL7A	1.45e-04	208	83	5	11790298
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	GTF3C1 WDR46 MAK16 DKC1 FBXO11 DDX27 RPL7A	1.60e-04	483	83	7	36912080
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	SF3B6 BAZ1B DKC1 MVP DDX27 RPL7A PPL NUP205	1.68e-04	652	83	8	31180492
Pubmed	Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.	MTA1 BAZ1B DKC1 DDX27 NUP205	1.69e-04	215	83	5	30462309
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	GTF3C1 RGPD8 APC DDX27 RGPD5	1.69e-04	215	83	5	35973513
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	BRD8 TCF25 DKC1 DDX27 PHLDB2 NUP205 KIF1C	1.88e-04	496	83	7	31343991
Pubmed	DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC.	ACTR5 BAZ1B NUP153 NUP205	1.88e-04	118	83	4	37105989
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	GTF3C1 SF3B6 BAZ1B CSTF3 DKC1 MVP DDX27 RPL7A NUP153	1.90e-04	847	83	9	35850772
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	DNAJB12 TCAF1 GTF3C1 RGPD8 SF3B6 DKC1 MAGT1 RPL7A GGCX NUP205 RGPD5	1.96e-04	1257	83	11	37317656
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	DYNLT2B CEP41 APC DKC1 MAST2 DDX27 TP53BP2 NUP205 KIF1C	2.00e-04	853	83	9	28718761
Pubmed	Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1.	EIF2AK4 RPL7A	2.00e-04	9	83	2	24113185
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	ZNF644 APC DKC1 MAST2 NUP153	2.41e-04	232	83	5	25515538
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	DNAJB12 TCF25 DKC1 IDE DDX27 GGCX	2.42e-04	364	83	6	24778252
Pubmed	EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.	APC MTUS2	2.50e-04	10	83	2	23001180
Pubmed	MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex.	MTA1 SIN3A	3.05e-04	11	83	2	15456747
Pubmed	De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.	SUPT6H BAZ1B	3.05e-04	11	83	2	31045206
Pubmed	Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes.	MTA1 SIN3A	3.05e-04	11	83	2	29263092
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD8 NUP153	3.05e-04	11	83	2	17069463
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	SUPT6H BAZ1B DKC1 SIN3A DDX27	3.58e-04	253	83	5	29911972
Pubmed	NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.	MTA1 SIN3A	3.66e-04	12	83	2	9885572
Pubmed	Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition.	CSTF3 PDZD7 RPL7A	3.87e-04	59	83	3	31551363
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	DNAJB12 MTA1 SUPT6H TCF25 CSTF3 SIN3A BCS1L	3.90e-04	560	83	7	35241646
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	TCAF1 SF3B6 CSTF3 SIN3A IDE MAGT1 MVP RPL7A PPL PHLDB2 NUP205	4.01e-04	1367	83	11	32687490
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	RGPD8 NUP153	4.31e-04	13	83	2	31427429
Pubmed	Optimising experimental design for high-throughput phenotyping in mice: a case study.	MTA1 BAZ1B	4.31e-04	13	83	2	20799038
Pubmed	The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.	MTA1 SIN3A	4.31e-04	13	83	2	12920132
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	PALS1 TCAF1 GTF3C1 TCF25 NUP153 NUP205 RGPD5	4.38e-04	571	83	7	37167062
Pubmed	RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.	DNAJB12 MAGT1 DDX27 PPL	4.46e-04	148	83	4	35676246
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	BRD8 MTA1 BAZ2A ZNF644 ATAD2B BAZ1B CSTF3 DKC1 NUP153	4.53e-04	954	83	9	36373674
Pubmed	Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.	MTA1 ZNF644 DDX27	4.69e-04	63	83	3	25680957
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PALS1 TCAF1 RGPD8 APC NBEA GRIK2 NUP153 PHLDB2 TP53BP2	4.85e-04	963	83	9	28671696
Pubmed	An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers.	BRD8 DDX27	5.03e-04	14	83	2	28981838
Pubmed	Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA.	MTA1 SIN3A	5.03e-04	14	83	2	20585571
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	MTA1 BAZ2A BAZ1B SIN3A	5.57e-04	157	83	4	30186101
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD8 NUP153	5.79e-04	15	83	2	14697343
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	DNAJB12 ZNF644 SLC27A1 BAZ1B FBXO11 SIN3A MAGT1 RPL7A GGCX NUP205	5.82e-04	1203	83	10	29180619
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	USF3 MTA1 TSPOAP1 SIN3A NUP153 TP53BP2	5.84e-04	430	83	6	35044719
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	WDR46 MAK16 BAZ1B DKC1 DDX27 RPL7A	5.84e-04	430	83	6	38172120
Pubmed	Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2 Virus.	GTF3C1 HELZ2 DKC1 DDX27	5.84e-04	159	83	4	34578187
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	MTA1 SUPT6H SF3B6 BAZ1B DKC1 DDX27 RPL7A	6.17e-04	605	83	7	28977666
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CYLC2 GTF3C1 RGPD8 SLC27A1 SKIDA1 DKC1 EIF2AK4 RPL7A PPL NUP205 RGPD5	6.25e-04	1442	83	11	35575683
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	MTA1 GTF3C1 BAZ2A ZNF644 ATAD2B BAZ1B SIN3A	6.35e-04	608	83	7	36089195
Interaction	NUP43 interactions	BRD8 MTA1 RGPD8 ACTR5 BAZ2A SUPT6H ZNF644 ATAD2B APC MAK16 DKC1 DDX27 RPL7A NUP153 RGPD5	2.05e-08	625	80	15	int:NUP43
Interaction	EED interactions	MTA1 GTF3C1 BAZ2A SUPT6H SF3B6 WDR46 SKIDA1 MAK16 BAZ1B DKC1 FBXO11 SIN3A MAGT1 MVP BAHD1 DDX27 RPL7A TENT2 NUP205	2.72e-06	1445	80	19	int:EED
Interaction	SIRT7 interactions	GTF3C1 BAZ2A SUPT6H ATAD2B WDR46 HELZ2 MAK16 BAZ1B MVP DDX27 RPL7A NUP153 NUP205	6.85e-06	744	80	13	int:SIRT7
Interaction	MEN1 interactions	GTF3C1 BAZ2A ZNF644 SF3B6 WDR46 TCF25 BAZ1B CSTF3 DKC1 SIN3A MVP DDX27 RPL7A NUP153 NUP205	1.11e-05	1029	80	15	int:MEN1
Interaction	LIN7B interactions	PALS1 APC MAK16 GRIK2	2.08e-05	41	80	4	int:LIN7B
Interaction	ZNF48 interactions	MAK16 DKC1 FBXO11 DDX27 MTUS2 RPL7A	2.83e-05	149	80	6	int:ZNF48
Interaction	SNRNP40 interactions	MTA1 BAZ2A SUPT6H ZNF644 ATAD2B SF3B6 MAK16 CSTF3 DKC1 DDX27 RPL7A	4.18e-05	637	80	11	int:SNRNP40
Interaction	FBL interactions	BRD8 GTF3C1 BAZ2A ZNF644 WDR46 MAK16 PAN2 BAZ1B DKC1 DDX27 NUP205	4.30e-05	639	80	11	int:FBL
Interaction	NPIPB6 interactions	RGPD8 NUP153 RGPD5	4.71e-05	18	80	3	int:NPIPB6
Interaction	ZNF330 interactions	GTF3C1 SUPT6H ZNF644 BAZ1B DKC1 SIN3A DDX27 RPL7A NUP205	6.78e-05	446	80	9	int:ZNF330
Interaction	RBM4B interactions	GTF3C1 HELZ2 APC MAK16 DKC1 DDX27 TENT2	8.20e-05	262	80	7	int:RBM4B
Interaction	RAN interactions	RGPD8 ZNF644 SF3B6 PAN2 SIN3A NUP153 NUP205 KIF1C RGPD5	1.10e-04	475	80	9	int:RAN
Interaction	H2AZ1 interactions	BRD8 MTA1 BAZ2A ZNF644 PAN2 BAZ1B SIN3A BAHD1	1.12e-04	371	80	8	int:H2AZ1
Interaction	IFI16 interactions	RGPD8 BAZ2A WDR46 HELZ2 MAK16 BAZ1B DKC1 DDX27 RPL7A NUP153 NUP205	1.16e-04	714	80	11	int:IFI16
Interaction	DCAF4 interactions	BAZ2A ZNF644 HELZ2 APC DKC1 SIN3A RPL7A PHLDB2	1.27e-04	378	80	8	int:DCAF4
GeneFamily	AAA ATPases\|Mitochondrial respiratory chain complex assembly factors	SDHAF3 ECSIT BCS1L	2.30e-04	40	54	3	645
Coexpression	MILI_PSEUDOPODIA	APC DKC1 PHLDB2 KIF1C	1.56e-05	48	82	4	M17507
Coexpression	MILI_PSEUDOPODIA	APC DKC1 PHLDB2 KIF1C	1.99e-05	51	82	4	MM824
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	GTF3C1 BAZ2A ATAD2B BAZ1B MAST2 NUP205	2.19e-05	180	82	6	M8239
Coexpression	GSE46242_TH1_VS_ANERGIC_TH1_CD4_TCELL_WITH_EGR2_DELETED_DN	OR2W3 ADAMTS15 OAS1 NMB MVP BAHD1	3.24e-05	193	82	6	M9717
Coexpression	GSE21380_NON_TFH_VS_TFH_CD4_TCELL_DN	CYLC2 TMEM106C HELZ2 EIF2AK4 CHRNB1 TP53BP2	3.96e-05	200	82	6	M7502
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	HELZ2 PAN2 OAS1 MVP DDX27	1.66e-05	170	83	5	07b561cd9c528bc8444c9385e1de621eee7b697e
ToppCell	18-Airway-Epithelial-Multiciliated_precursor\|Airway / Age, Tissue, Lineage and Cell class	DYNLT2B TMEM106C CEP41 DNAAF1 KIF24	2.37e-05	183	83	5	a75cda2131755931117c387f2e0ae3394efa8e80
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNLT2B TMEM106C CEP41 DNAAF1 KIF24	2.83e-05	190	83	5	da60bcc4b59d8e3719d8201387d567594059b1a4
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DYNLT2B TMEM106C CEP41 DNAAF1 KIF24	2.83e-05	190	83	5	827a1f4e4ac4beada262f4fb965dd74a447a8f4f
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Myeloid-Cd4_positive_Macrophages\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR46 MAK16 DKC1 ACY1 ECSIT	2.90e-05	191	83	5	45023854f285ac465f23ea1b33c970e14992e709
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR46 MAK16 DKC1 ACY1 ECSIT	2.90e-05	191	83	5	6890a8e4b4530987a5b044614fcd7e00716a4d66
ToppCell	(04)_Pre-ciliated\|World / shred by cell type and Timepoint	DYNLT2B CEP41 DNAAF1 MAST2 NUP205	2.90e-05	191	83	5	37cf121e6e80760c8519075b7845b9029958a988
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	ZNF644 HELZ2 TCF25 OAS1 TENT2	3.45e-05	198	83	5	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF644 HELZ2 TCF25 OAS1 TENT2	3.45e-05	198	83	5	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZNF644 ATAD2B HELZ2 TCF25 OAS1	3.62e-05	200	83	5	12f1685ce8f218433068e090c9d839cd5a1910bf
Drug	(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; PC3; HT_HG-U133A	BAZ2A GPR37 BAZ1B GRIK2 MAST2 BAHD1 CHRNB1	5.97e-06	194	81	7	4524_DN
Drug	Methiazole; Down 200; 15uM; PC3; HT_HG-U133A	BAZ2A APC GRIK2 MAST2 MVP DENND2B CHRNB1	6.61e-06	197	81	7	4532_DN
Disease	response to triptolide, cytotoxicity measurement	MTUS2 TP53BP2	8.71e-04	16	81	2	EFO_0006952, EFO_0007662
Disease	obsessive-compulsive disorder, Tourette syndrome	ACOD1 CYLC2	2.32e-03	26	81	2	EFO_0004242, EFO_0004895
Disease	S-warfarin measurement	GPR37 MAK16 EIF2AK4	2.44e-03	97	81	3	EFO_0803323

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALHYLVPVRPRRQIV	CFAP61	611	Q8NHU2
PIPVHQLRRYTAQLL	EIF2AK4	396	Q9P2K8
AYQARQAVKTPPRRL	BRD8	166	Q9H0E9
LIRTERPPNKEIVRY	BAZ1B	241	Q9UIG0
PVNPRLVSGYRRIIK	BAZ2A	1821	Q9UIF9
YPRRRRPLNSVVLQQ	BCS1L	181	Q9Y276
PNRVLSYRVKQLVFP	GSDMB	201	Q8TAX9
RIPQNPRYQHIKSRL	CEP41	16	Q9BYV8
IRRKPLFYLVNVIAP	CHRNB1	241	P11230
YLAARRQPLKPTRTV	CYLC2	91	Q14093
RPQLIRAKVPIVKFR	TENT2	256	Q6PIY7
SNIYVPIRLPKQASR	ACTR5	571	Q9H9F9
RPPFQQIRLTLRKFN	NPR1	791	P16066
RRIPKLVQRINSIYN	DENND2B	611	P78524
VLERLIYKPRQAPVT	DDX27	276	Q96GQ7
IYKPRQAPVTRVLVL	DDX27	281	Q96GQ7
RNLLGLYPRIKPRQR	TP53BP2	1111	Q13625
RLYRHPSILNPINIV	ADAMTS15	251	Q8TE58
RPKIITYIRRNPQAL	MTUS2	641	Q5JR59
YLIAFQVPRPKIKLR	RGPD5	321	Q99666
YLIAFQVPRPKIKLR	RGPD8	321	O14715
VPYPRRLVVLKQLAH	TSPOAP1	791	O95153
RPPQRQVVLSKFVRQ	NUP205	486	Q92621
PRTRLRNQIPYRLKE	PAN2	446	Q504Q3
FRRLVKAPPRNYSVI	MAGT1	61	Q9H0U3
PLRGPLQRKRAYVEI	MAK16	271	Q9BXY0
LRQRKTVDRYQAPPI	ATAD2B	286	Q9ULI0
VTPLLNPLIYTLRNR	OR2W3	281	Q7Z3T1
LQKRGQQVVPLKYRR	PPL	381	O60437
RYLLRKQQRLLNGPP	PDZD7	41	Q9H5P4
VPPVHDIYRARQQKR	CSTF3	701	Q12996
SGKRRAPRRVYQIPQ	KIF1C	716	O43896
YQIPQRRRLQGKDPR	KIF1C	726	O43896
LKRSLRQYRPPEGQL	KIF24	786	Q5T7B8
PIIEKYLRRQLTKPR	OAS1	281	P00973
YLRRQLTKPRPVILD	OAS1	286	P00973
LQPLAPRNKTRVVSY	MVP	446	Q14764
VTPLLNPIVYSLRNR	OR10Z1	281	Q8NGY1
LYHQPANRKRPIILI	PALS1	471	Q8N3R9
RETAIQFKPPLYRQR	HENMT1	21	Q5T8I9
TNRRVRLKNPFYPLT	GPR37	241	O15354
LVNVKSRLKQAPRYP	DENND2A	536	Q9ULE3
NSPYQLRRKTLLPKR	FBXO11	96	Q86XK2
PRPRVTYQVLRKNVY	CDHR3	691	Q6ZTQ4
LEKAQRLYPTPRVRA	DNAJB12	31	Q9NXW2
RRKNYPLRKRPLVPE	BAHD1	51	Q8TBE0
QVQPRRYLKKLPLQA	MAN2A2	906	P49641
GLAPKLQRQYRSPRR	MAST2	1321	Q6P0Q8
PVIRQIPNYRRTVTV	DNAAF1	256	Q8NEP3
RPCLRLKVYVRPTNE	EFNA2	161	O43921
LPTDYIKRIVLRIPN	ACOD1	301	A6NK06
KPLLPSQLVRYREVQ	IDE	756	P14735
APSRYNLRLKIRQLP	GRIK2	191	Q13002
QVPIYSLRKGRLQRV	HELZ2	1236	Q9BYK8
FQRPPLIAAVKRQLR	DKC1	181	O60832
ARKPLRPDSLIIYRQ	FAM110C	91	Q1W6H9
ALYKRVLQLHRVLPP	SDHAF3	11	Q9NRP4
LRPVFQQRFRPSVVK	DYNLT2B	31	Q8WW35
FPKEVFRPRNIIQRI	ECSIT	136	Q9BQ95
IRRAINKYPPINLKI	COL6A6	2166	A6NMZ7
DQRLRPQRTKQYVLL	TMEM106C	76	Q9BVX2
NARKAPQPEVRRYVL	RPE65	356	Q16518
IIRKESLPPPYRLQQ	PRSS29P	201	A6NIE9
RYRLPVATRENPVIN	TCAF1	471	Q9Y4C2
QRAILYKRLKVPPAI	RPL7A	66	P62424
LPLQQYKLVRPRVVN	FEZF1	136	A0PJY2
PQARRISLATPRQLY	NBEA	2266	Q8NFP9
YRTLVLGKRPVLQTP	SKIDA1	781	Q1XH10
IDYRLAQRRPQKPKQ	SMIM38	36	A0A286YFK9
QKPVFLPRNLRRIRK	SIN3A	1121	Q96ST3
APKIRVPRHLRQTYI	MYBPH	171	Q13203
ARRPYKPIALRQSQA	MTA1	681	Q13330
RQRAQARPLTRYLPV	PHLDB2	1101	Q86SQ0
FRQYLRIRTVQPKPD	ACY1	16	Q03154
VKPIPQNTEYRTRVR	APC	1776	P25054
YPPVLRQAVSLARRI	SUPT6H	906	Q7KZ85
PRKLVSYCPRRLQQL	GGCX	316	P38435
RILPHVYPIRLVKVN	SLC27A1	411	Q6PCB7
IRLPPEVNRILYIRN	SF3B6	11	Q9Y3B4
SLSRPAPQIQYRRLL	NMB	101	P08949
IDRQKRLSYPPVQSI	USF3	1786	Q68DE3
SKLRNTPYQAPVRRQ	NUP153	276	P49790
RELRPQRPKNAYILK	WDR46	51	O15213
LNSRRIIPRPFVAQK	ZNF644	1096	Q9H582
FLPRPIRQQLLYKRR	GTF3C1	946	Q12789
LGEQRPRQRQRVYPK	TCF25	201	Q9BQ70