Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sulfur amino acid transmembrane transporter activity	SLC7A11 SLC3A1 SLC7A9 CTNS	9.43e-07	11	149	4	GO:0000099
GeneOntologyMolecularFunction	L-cystine transmembrane transporter activity	SLC3A1 SLC7A9 CTNS	1.62e-06	4	149	3	GO:0015184
GeneOntologyMolecularFunction	orexin receptor activity	HCRTR1 HCRTR2	5.53e-05	2	149	2	GO:0016499
GeneOntologyMolecularFunction	olfactory receptor activity	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 OR6X1 OR4A8 OR5H6 OR56A3	9.70e-05	431	149	12	GO:0004984
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	SLC7A11 SLC3A1 SLC7A9 CTNS	1.03e-04	33	149	4	GO:0072349
GeneOntologyMolecularFunction	G-protein activated inward rectifier potassium channel activity	KCNJ5 KCNJ6	3.29e-04	4	149	2	GO:0015467
GeneOntologyMolecularFunction	antiporter activity	SLC35A1 SLC7A11 SLC7A9 SLC9A5 SLC24A2 SLC35A5	5.97e-04	138	149	6	GO:0015297
GeneOntologyBiologicalProcess	L-cystine transport	SLC7A11 SLC3A1 SLC7A9 CTNS	3.88e-08	6	149	4	GO:0015811
GeneOntologyBiologicalProcess	sulfur amino acid transport	SLC7A11 SLC3A1 SLC7A9 CTNS	1.78e-06	13	149	4	GO:0000101
GeneOntologyBiologicalProcess	sensory perception of smell	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 ADCY3 OR6X1 OR4A8 OR5H6 OR56A3	3.40e-05	465	149	13	GO:0007608
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 ADCY3 OR6X1 ITPR3 OR4A8 OR5H6 OR56A3	4.42e-05	547	149	14	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 OR6X1 OR4A8 OR5H6 OR56A3	7.32e-05	432	149	12	GO:0050911
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 OR6X1 OR4A8 TLR2 OR5H6 OR56A3	1.14e-04	524	149	13	GO:0009593
GeneOntologyCellularComponent	DNA repair complex	BRCA2 FANCI ATM ASCC3	2.03e-05	23	150	4	GO:1990391
Domain	Orexin_rcpt	HCRTR1 HCRTR2	5.99e-05	2	145	2	IPR000204
Domain	ARM-type_fold	PPP4R1 INTS1 ARFGEF2 NBEA TRRAP FOCAD RPTOR RRP12 DIAPH2 ATM BRAT1	6.96e-05	339	145	11	IPR016024
Domain	Olfact_rcpt	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 OR6X1 OR5H6 OR56A3	2.54e-04	393	145	11	IPR000725
Domain	Nuc_sug_transp	SLC35A1 SLC35A5	5.89e-04	5	145	2	PF04142
Domain	Nuc_sug_transpt	SLC35A1 SLC35A5	5.89e-04	5	145	2	IPR007271
Domain	FAT	TRRAP ATM	8.80e-04	6	145	2	PS51189
Domain	FATC	TRRAP ATM	8.80e-04	6	145	2	PS51190
Domain	FAT	TRRAP ATM	8.80e-04	6	145	2	PF02259
Domain	PIK-rel_kinase_FAT	TRRAP ATM	8.80e-04	6	145	2	IPR003151
Domain	FATC_dom	TRRAP ATM	8.80e-04	6	145	2	IPR003152
Domain	PIK_FAT	TRRAP ATM	8.80e-04	6	145	2	IPR014009
Domain	FATC	TRRAP ATM	8.80e-04	6	145	2	SM01343
Domain	Znf_GRF	ZGRF1 NEIL3	1.23e-03	7	145	2	IPR010666
Domain	zf-GRF	ZGRF1 NEIL3	1.23e-03	7	145	2	PF06839
Domain	ARM-like	PPP4R1 ARFGEF2 NBEA TRRAP RPTOR RRP12 TAF7L BRAT1	1.25e-03	270	145	8	IPR011989
Domain	DHC_N1	DNAH8 DNAH11	1.63e-03	8	145	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH8 DNAH11	1.63e-03	8	145	2	IPR013594
Domain	GPCR_Rhodpsn_7TM	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 OR6X1 OR5H6 OR56A3 HCRTR1 HCRTR2	2.19e-03	670	145	13	IPR017452
Domain	7tm_1	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 OR6X1 OR5H6 OR56A3 HCRTR1 HCRTR2	2.40e-03	677	145	13	PF00001
Domain	IGc2	ROBO4 MXRA5 ADAMTSL3 IL1RAPL1 MFAP3 LINGO1 ALCAM	2.43e-03	235	145	7	SM00408
Domain	Ig_sub2	ROBO4 MXRA5 ADAMTSL3 IL1RAPL1 MFAP3 LINGO1 ALCAM	2.43e-03	235	145	7	IPR003598
Domain	G_PROTEIN_RECEP_F1_1	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 OR6X1 OR5H6 OR56A3 HCRTR1 HCRTR2	2.66e-03	685	145	13	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 OR6X1 OR5H6 OR56A3 HCRTR1 HCRTR2	2.86e-03	691	145	13	PS50262
Domain	GPCR_Rhodpsn	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 OR6X1 OR5H6 OR56A3 HCRTR1 HCRTR2	2.90e-03	692	145	13	IPR000276
Domain	Ig_I-set	ROBO4 MXRA5 ADAMTSL3 IL1RAPL1 MFAP3 LINGO1	3.71e-03	190	145	6	IPR013098
Domain	I-set	ROBO4 MXRA5 ADAMTSL3 IL1RAPL1 MFAP3 LINGO1	3.71e-03	190	145	6	PF07679
Domain	AA_permease_2	SLC7A11 SLC7A9	4.41e-03	13	145	2	PF13520
Domain	AA/rel_permease1	SLC7A11 SLC7A9	4.41e-03	13	145	2	IPR002293
Domain	Dynein_heavy_chain_D4_dom	DNAH8 DNAH11	5.12e-03	14	145	2	IPR024317
Domain	Dynein_HC_stalk	DNAH8 DNAH11	5.12e-03	14	145	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH8 DNAH11	5.12e-03	14	145	2	IPR013602
Domain	DHC_N2	DNAH8 DNAH11	5.12e-03	14	145	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH8 DNAH11	5.12e-03	14	145	2	IPR011704
Domain	MT	DNAH8 DNAH11	5.12e-03	14	145	2	PF12777
Domain	AAA_8	DNAH8 DNAH11	5.12e-03	14	145	2	PF12780
Domain	AAA_5	DNAH8 DNAH11	5.12e-03	14	145	2	PF07728
Domain	DHC_fam	DNAH8 DNAH11	5.88e-03	15	145	2	IPR026983
Domain	Dynein_heavy	DNAH8 DNAH11	5.88e-03	15	145	2	PF03028
Domain	Dynein_heavy_dom	DNAH8 DNAH11	5.88e-03	15	145	2	IPR004273
Domain	HEAT	PPP4R1 RPTOR BRAT1	6.14e-03	48	145	3	PF02985
Domain	-	TRRAP ATM	6.69e-03	16	145	2	1.10.1070.11
Domain	IRK	KCNJ5 KCNJ6	6.69e-03	16	145	2	PF01007
Domain	PI3Kc	TRRAP ATM	6.69e-03	16	145	2	SM00146
Domain	K_chnl_inward-rec_Kir_cyto	KCNJ5 KCNJ6	6.69e-03	16	145	2	IPR013518
Domain	-	KCNJ5 KCNJ6	6.69e-03	16	145	2	2.60.40.1400
Domain	K_chnl_inward-rec_Kir	KCNJ5 KCNJ6	6.69e-03	16	145	2	IPR016449
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 ADCY3 OR6X1 OR4A8 OR5H6 OR56A3	2.38e-05	417	111	13	M4072
Pubmed	Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.	BRCA2 FANCI ATM	7.97e-07	5	151	3	15199141
Pubmed	The human olfactory receptor gene family.	OR7G1 OR4K17 OR2AP1 OR4D10 OR2G3 OR6C74 OR2W1 OR2T2 OR6X1 OR4A8 OR5H6 OR56A3	4.71e-06	541	151	12	14983052
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	INTS1 ARFGEF2 TRRAP FANCI DIAPH2 ATM	6.48e-06	104	151	6	31240132
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	TRRAP RPTOR ATM	1.29e-05	11	151	3	20427287
Pubmed	Twenty-four novel mutations identified in a cohort of 85 patients by direct sequencing of the SLC3A1 and SLC7A9 cystinuria genes.	SLC3A1 SLC7A9	1.87e-05	2	151	2	18752446
Pubmed	Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.	HCRTR1 HCRTR2	1.87e-05	2	151	2	34475397
Pubmed	G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells.	HCRTR1 HCRTR2	1.87e-05	2	151	2	27237973
Pubmed	Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.	HCRTR1 HCRTR2	1.87e-05	2	151	2	26950369
Pubmed	An overview of SLC3A1 and SLC7A9 mutations in Greek cystinuria patients.	SLC3A1 SLC7A9	1.87e-05	2	151	2	18778962
Pubmed	Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.	HCRTR1 HCRTR2	1.87e-05	2	151	2	22389503
Pubmed	Human cystinuria-related transporter: localization and functional characterization.	SLC3A1 SLC7A9	1.87e-05	2	151	2	11318953
Pubmed	Significant contribution of genomic rearrangements in SLC3A1 and SLC7A9 to the etiology of cystinuria.	SLC3A1 SLC7A9	1.87e-05	2	151	2	14531788
Pubmed	New insights into cystinuria: 40 new mutations, genotype-phenotype correlation, and digenic inheritance causing partial phenotype.	SLC3A1 SLC7A9	1.87e-05	2	151	2	15635077
Pubmed	Co-localization and interaction of b0,+-type amino acid transporter 1 (BAT1) with caveolin-1 in rat kidney.	SLC3A1 SLC7A9	1.87e-05	2	151	2	16358225
Pubmed	Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala.	HCRTR1 HCRTR2	1.87e-05	2	151	2	24485472
Pubmed	Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9.	SLC3A1 SLC7A9	1.87e-05	2	151	2	32873097
Pubmed	Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia.	SLC7A11 ATM	1.87e-05	2	151	2	26469940
Pubmed	Spectrum of mutations in cystinuria patients presenting with prenatal hyperechoic colon.	SLC3A1 SLC7A9	1.87e-05	2	151	2	28646536
Pubmed	Large rearrangements detected by MLPA, point mutations, and survey of the frequency of mutations within the SLC3A1 and SLC7A9 genes in a cohort of 172 cystinuric Italian patients.	SLC3A1 SLC7A9	1.87e-05	2	151	2	19782624
Pubmed	Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1.	BRCA2 BUB1B	1.87e-05	2	151	2	10749118
Pubmed	Comment on "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2".	HCRTR1 HCRTR2	1.87e-05	2	151	2	26582896
Pubmed	Cystinuria in children: distribution and frequencies of mutations in the SLC3A1 and SLC7A9 genes.	SLC3A1 SLC7A9	1.87e-05	2	151	2	12234283
Pubmed	Differential influence of the 4F2 heavy chain and the protein related to b(0,+) amino acid transport on substrate affinity of the heteromeric b(0,+) amino acid transporter.	SLC3A1 SLC7A9	1.87e-05	2	151	2	10799513
Pubmed	Clinical and genetic analysis of patients with cystinuria in the United Kingdom.	SLC3A1 SLC7A9	1.87e-05	2	151	2	25964309
Pubmed	Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy.	ATG7 RPTOR	1.87e-05	2	151	2	34862201
Pubmed	Mutation analysis of SLC3A1 and SLC7A9 genes in patients with cystinuria.	SLC3A1 SLC7A9	1.87e-05	2	151	2	26123750
Pubmed	The population-specific distribution and frequencies of genomic variants in the SLC3A1 and SLC7A9 genes and their application in molecular genetic testing of cystinuria.	SLC3A1 SLC7A9	1.87e-05	2	151	2	14991253
Pubmed	Metastatic Prostate Cancers with BRCA2 versus ATM Mutations Exhibit Divergent Molecular Features and Clinical Outcomes.	BRCA2 ATM	1.87e-05	2	151	2	37126020
Pubmed	Associating mutations causing cystinuria with disease severity with the aim of providing precision medicine.	SLC3A1 SLC7A9	1.87e-05	2	151	2	28812535
Pubmed	Association of orexin receptor polymorphisms with antipsychotic-induced weight gain.	HCRTR1 HCRTR2	1.87e-05	2	151	2	26447462
Pubmed	ISG15 Promotes Progression and Gemcitabine Resistance of Pancreatic Cancer Cells Through ATG7.	ATG7 ISG15	1.87e-05	2	151	2	38385083
Pubmed	Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons.	HCRTR1 HCRTR2	1.87e-05	2	151	2	20576035
Pubmed	Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation.	HCRTR1 HCRTR2	1.87e-05	2	151	2	34126185
Pubmed	In silico analysis of SLC3A1 and SLC7A9 mutations in Iranian patients with Cystinuria.	SLC3A1 SLC7A9	1.87e-05	2	151	2	30069816
Pubmed	Increased plasma orexin-A levels in patients with insomnia disorder are not associated with prepro-orexin or orexin receptor gene polymorphisms.	HCRTR1 HCRTR2	1.87e-05	2	151	2	27988352
Pubmed	Population genetics analysis of SLC3A1 and SLC7A9 revealed the etiology of cystine stone may be more than what our current genetic knowledge can explain.	SLC3A1 SLC7A9	1.87e-05	2	151	2	37561200
Pubmed	Molecular genetic analysis of SLC3A1 and SLC7A9 genes in Czech and Slovak cystinuric patients.	SLC3A1 SLC7A9	1.87e-05	2	151	2	16138908
Pubmed	rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney.	SLC3A1 SLC7A9	1.87e-05	2	151	2	12167606
Pubmed	Orexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinction.	HCRTR1 HCRTR2	1.87e-05	2	151	2	21510948
Pubmed	Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.	HCRTR1 HCRTR2	1.87e-05	2	151	2	11723285
Pubmed	Synergistic mutations in SLC3A1 and SLC7A9 leading to heterogeneous cystinuria phenotypes: pitfalls in the diagnostic workup.	SLC3A1 SLC7A9	1.87e-05	2	151	2	24045899
Pubmed	Extreme Response to High-dose Testosterone in BRCA2- and ATM-mutated Prostate Cancer.	BRCA2 ATM	1.87e-05	2	151	2	27692705
Pubmed	Cellular localization of orexin receptors in human pituitary.	HCRTR1 HCRTR2	1.87e-05	2	151	2	11443222
Pubmed	Interpretation of SLC3A1 and SLC7A9 variants in cystinuria patients: The significance of the PM3 criterion and protein stability.	SLC3A1 SLC7A9	1.87e-05	2	151	2	37439839
Pubmed	Clinical and genetic characterization of Chinese pediatric cystine stone patients.	SLC3A1 SLC7A9	1.87e-05	2	151	2	28689648
Pubmed	SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis.	TEX11 SHOC1	1.87e-05	2	151	2	29742103
Pubmed	Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants.	HCRTR1 HCRTR2	1.87e-05	2	151	2	15256537
Pubmed	Association between pathogenic germline mutations in BRCA2 and ATM and tumor-infiltrating lymphocytes in primary prostate cancer.	BRCA2 ATM	1.87e-05	2	151	2	34533610
Pubmed	Molecular and Clinical Investigation of Cystinuria in the Greek-Cypriot Population.	SLC3A1 SLC7A9	1.87e-05	2	151	2	26540609
Pubmed	Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells.	HCRTR1 HCRTR2	1.87e-05	2	151	2	15797953
Pubmed	Clinical profile of a Polish cohort of children and young adults with cystinuria.	SLC3A1 SLC7A9	1.87e-05	2	151	2	33349102
Pubmed	Peripherally administered orexin improves survival of mice with endotoxin shock.	HCRTR1 HCRTR2	1.87e-05	2	151	2	28035899
Pubmed	Whole Brain Mapping of Orexin Receptor mRNA Expression Visualized by Branched In Situ Hybridization Chain Reaction.	HCRTR1 HCRTR2	1.87e-05	2	151	2	38199807
Pubmed	Hcrtr1 and 2 signaling differentially regulates depression-like behaviors.	HCRTR1 HCRTR2	1.87e-05	2	151	2	21377495
Pubmed	Mutation analysis of SLC7A9 in cystinuria patients in Sweden.	SLC3A1 SLC7A9	1.87e-05	2	151	2	12820697
Pubmed	Luminal heterodimeric amino acid transporter defective in cystinuria.	SLC3A1 SLC7A9	1.87e-05	2	151	2	10588648
Pubmed	Clinical, Biochemical, and Genetic Findings of Cystinuria in Chinese Children.	SLC3A1 SLC7A9	1.87e-05	2	151	2	30146843
Pubmed	Comparison between SLC3A1 and SLC7A9 cystinuria patients and carriers: a need for a new classification.	SLC3A1 SLC7A9	1.87e-05	2	151	2	12239244
Pubmed	Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy.	HCRTR1 HCRTR2	1.87e-05	2	151	2	18714784
Pubmed	Structural basis for amino acid exchange by a human heteromeric amino acid transporter.	SLC3A1 SLC7A9	1.87e-05	2	151	2	32817565
Pubmed	Clinical, biochemical and molecular characterization of cystinuria in a cohort of 12 patients.	SLC3A1 SLC7A9	1.87e-05	2	151	2	21255007
Pubmed	Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization.	HCRTR1 HCRTR2	1.87e-05	2	151	2	27683906
Pubmed	Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice.	HCRTR1 HCRTR2	1.87e-05	2	151	2	21533254
Pubmed	P. gingivalis-Induced TLR2 Interactome Analysis Reveals Association with PARP9.	TLR2 PARP9	1.87e-05	2	151	2	38344758
Pubmed	Cryo-EM structure of the human heteromeric amino acid transporter b0,+AT-rBAT.	SLC3A1 SLC7A9	1.87e-05	2	151	2	32494597
Pubmed	Panic disorder is associated with the Val308Iso polymorphism in the hypocretin receptor gene.	HCRTR1 HCRTR2	1.87e-05	2	151	2	21666548
Pubmed	Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice.	HCRTR1 HCRTR2	1.87e-05	2	151	2	26996108
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR7G1 OR2AP1 OR4D10 OR6C74 OR2W1 OR6X1 OR4A8 OR5H6 OR56A3	1.92e-05	340	151	9	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR7G1 OR2AP1 OR4D10 OR6C74 OR2W1 OR6X1 OR4A8 OR5H6 OR56A3	1.92e-05	340	151	9	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR7G1 OR2AP1 OR4D10 OR6C74 OR2W1 OR6X1 OR4A8 OR5H6 OR56A3	2.06e-05	343	151	9	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR7G1 OR2AP1 OR4D10 OR6C74 OR2W1 OR6X1 OR4A8 OR5H6 OR56A3	2.20e-05	346	151	9	14611657
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	CAD RPP30 NUP214 TRRAP ITPR3 KIF20A RRP12 HASPIN ASCC3 DHX29	2.43e-05	440	151	10	34244565
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CAD COPB2 INTS1 NUP214 TRRAP TASOR2 ITPR3 UTP15 FANCI RRP12 ATM ASCC3	3.04e-05	653	151	12	22586326
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	EXOC6 TBC1D15 ARFGEF2 NUP214 ITPR3 FANCI CEP135 ASCC3	3.72e-05	285	151	8	32838362
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	RC3H2 INTS1 NUP214 TRRAP TASOR2 KIF20A INTS2 FANCI HASPIN ASCC3	4.17e-05	469	151	10	27634302
Pubmed	Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.	HCRTR1 HCRTR2	5.60e-05	3	151	2	9491897
Pubmed	Obesity and the hypothalamus: novel peptides for new pathways.	HCRTR1 HCRTR2	5.60e-05	3	151	2	9491885
Pubmed	BRCA2 is required for neurogenesis and suppression of medulloblastoma.	BRCA2 ATM	5.60e-05	3	151	2	17476307
Pubmed	Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study.	BRCA2 ATM	5.60e-05	3	151	2	15084244
Pubmed	Hypocretin/orexin, sleep and narcolepsy.	HCRTR1 HCRTR2	5.60e-05	3	151	2	11340621
Pubmed	Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep.	HCRTR1 HCRTR2	5.60e-05	3	151	2	21525292
Pubmed	Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons.	ADCY3 STOML3	5.60e-05	3	151	2	12122055
Pubmed	Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents.	BUB1B ATM	5.60e-05	3	151	2	34545188
Pubmed	Mutations in ATM, NBN and BRCA2 predispose to aggressive prostate cancer in Poland.	BRCA2 ATM	5.60e-05	3	151	2	32875559
Pubmed	Hyperalgesia and blunted morphine analgesia in G protein-gated potassium channel subunit knockout mice.	KCNJ5 KCNJ6	5.60e-05	3	151	2	12499858
Pubmed	Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas.	BRCA2 BUB1B	5.60e-05	3	151	2	14646599
Pubmed	Identification of Key Prognostic Biomarker and Its Correlation with Immune Infiltrates in Pancreatic Ductal Adenocarcinoma.	COL6A3 FBN1	5.60e-05	3	151	2	32934754
Pubmed	To eat or to sleep? Orexin in the regulation of feeding and wakefulness.	HCRTR1 HCRTR2	5.60e-05	3	151	2	11283317
Pubmed	Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors.	HCRTR1 HCRTR2	5.60e-05	3	151	2	24530395
Pubmed	Toll-like receptor 2 and 4 induced interleukin-19 dampens immune reactions and associates inversely with spondyloarthritis disease activity.	TLR2 IL19	5.60e-05	3	151	2	25639337
Pubmed	BRCA2, ATM, and CDK12 Defects Differentially Shape Prostate Tumor Driver Genomics and Clinical Aggression.	BRCA2 ATM	5.60e-05	3	151	2	33414135
Pubmed	Screening for ATM sequence alterations in African-American women diagnosed with breast cancer.	BRCA2 ATM	5.60e-05	3	151	2	17333338
Pubmed	Absence of mutations in HCRT, HCRTR1 and HCRTR2 in patients with ROHHAD.	HCRTR1 HCRTR2	5.60e-05	3	151	2	26555080
Pubmed	Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models.	HCRTR1 HCRTR2	5.60e-05	3	151	2	28507129
Pubmed	Identification of GIRK2-4 subunits in human esophageal smooth muscle cells.	KCNJ5 KCNJ6	5.60e-05	3	151	2	21637918
Pubmed	Differential Roles of Each Orexin Receptor Signaling in Obesity.	HCRTR1 HCRTR2	5.60e-05	3	151	2	31546102
Pubmed	Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis.	FBN1 BRCA2	5.60e-05	3	151	2	25749384
Pubmed	Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.	HCRTR1 HCRTR2	5.60e-05	3	151	2	31983458
Pubmed	A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway.	ISG15 ATM	5.60e-05	3	151	2	21298066
Pubmed	Mechanism of RAD51-dependent DNA interstrand cross-link repair.	BRCA2 FANCI	5.60e-05	3	151	2	21719678
GeneFamily	Hypocretin receptors	HCRTR1 HCRTR2	3.34e-05	2	105	2	228
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ROBO4 MXRA5 ADAMTSL3 IL1RAPL1 MFAP3 LINGO1	3.54e-04	161	105	6	593
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND4A DENND6A SMCR8	3.99e-04	25	105	3	504
GeneFamily	Solute carriers	SLC35A1 SLC7A11 SLC3A1 SLC7A9 SLC25A36 SLC9A5 SLC16A4 SLC24A2 SLC35A5	4.91e-04	395	105	9	752
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	ARFGEF2 NBEA CMYA5	6.23e-04	29	105	3	396
GeneFamily	Zinc fingers GRF-type\|Topoisomerases	ZGRF1 NEIL3	6.88e-04	7	105	2	135
GeneFamily	Integrator complex	INTS1 INTS2	3.34e-03	15	105	2	1366
GeneFamily	Potassium voltage-gated channel subfamily J	KCNJ5 KCNJ6	3.80e-03	16	105	2	276
GeneFamily	Olfactory receptors, family 2	OR2AP1 OR2G3 OR2W1 OR2T2	4.26e-03	113	105	4	149
GeneFamily	Dyneins, axonemal	DNAH8 DNAH11	4.29e-03	17	105	2	536
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	BRCA2 FANCI	5.93e-03	20	105	2	548
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_500	CASP8AP2 CAD ZGRF1 ARFGEF2 TEX11 TASOR2 BRCA2 FANCI TAF7L ATM METTL25 DNAH8	7.16e-06	385	136	12	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_500
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#4_top-relative-expression-ranked_500	CASP8AP2 ZGRF1 TASOR2 BRCA2 TAF7L ATM DNAH8	1.98e-05	129	136	7	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k4_500
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_1000	ZGRF1 ARFGEF2 BRCA2 FANCI ATM DNAH8	5.61e-05	104	136	6	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k2_1000
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 ZGRF1 FBN1 BRCA2 MICAL2 FANCI BUB1B NEIL3	1.29e-07	171	151	8	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 ZGRF1 FBN1 BRCA2 MICAL2 FANCI BUB1B NEIL3	1.29e-07	171	151	8	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ELAPOR2 WFS1 DIPK2B HIVEP3 FBN1 SNCAIP MICAL2	2.08e-07	182	151	8	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ELAPOR2 WFS1 DIPK2B HIVEP3 FBN1 SNCAIP MICAL2	2.08e-07	182	151	8	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ELAPOR2 WFS1 DIPK2B HIVEP3 FBN1 SNCAIP MICAL2	2.08e-07	182	151	8	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 ZGRF1 KIF20A FBN1 BRCA2 FANCI BUB1B NEIL3	2.56e-07	187	151	8	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 ZGRF1 KIF20A FBN1 BRCA2 FANCI BUB1B NEIL3	2.56e-07	187	151	8	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	facs-Kidney-nan-3m-Lymphocytic-T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND4A ZGRF1 ITGAD ZDHHC15 GZMA SCN10A SV2C	1.43e-06	163	151	7	385b24e18df5ef92108483de312d6c85a1e6d145
ToppCell	facs-Kidney-nan-3m-Lymphocytic-T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND4A ZGRF1 ITGAD ZDHHC15 GZMA SCN10A SV2C	1.43e-06	163	151	7	8004cc0b3428be08b89957b563cd8799f822d931
ToppCell	facs-Kidney-nan-3m-Lymphocytic\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND4A ZGRF1 ITGAD ITPR3 ZDHHC15 GZMA SCN10A	1.56e-06	165	151	7	ba041deb0d9c187f251493ccd4794b5f09abd5aa
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CASP8AP2 ZGRF1 ADCY3 BRCA2 FANCI BUB1B NEIL3	1.82e-06	169	151	7	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZGRF1 KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	1.82e-06	169	151	7	e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CASP8AP2 ZGRF1 BRCA2 FANCI BUB1B HASPIN NEIL3	2.67e-06	179	151	7	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	LPS-IL1RA-Endothelial-Endothelial-FOXM1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZGRF1 KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	2.77e-06	180	151	7	334e2b1f6eb7d4ece20b1c7b02107863f913237f
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZGRF1 KIF20A BRCA2 FANCI BUB1B OR56A3 NEIL3	2.77e-06	180	151	7	f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCell	ILEUM-inflamed-(7)_Lymphatics\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MAGI1 ROBO4 WFS1 CMYA5 UBE2U DIPK2B SNCAIP	3.32e-06	185	151	7	d711dd2e91cfee723dae1ccb2b910b8cf3becc3b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZGRF1 DIPK2B KIF20A BRCA2 FANCI BUB1B NEIL3	3.96e-06	190	151	7	31de1727822e9818652946dfb962daee77ffad68
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZGRF1 DACH2 BRCA2 FANCI BUB1B NEIL3 LRRC7	3.96e-06	190	151	7	e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NUP214 KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	4.54e-06	194	151	7	e5b81a8e52259a54a911c1c2ac932c98c988318d
ToppCell	COVID-19-lung-Proliferative_fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	COL6A3 ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	4.86e-06	196	151	7	2ce8a787f2731faa913d20342d73041d59468f27
ToppCell	COVID-19-lung-Proliferative_fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL6A3 ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	4.86e-06	196	151	7	ca91d5e325875e7444809b80fcbd491d8899ea36
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CFAP47 CFAP91 MYO1H KIF20A KIAA0825 ZFHX2 DNAH11	5.02e-06	197	151	7	6e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCell	distal-3-Endothelial-Bronchial_Vessel_2\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MAGI1 ROBO4 NBEA SLC7A11 DIPK2B ZDHHC15 KIAA0825	5.19e-06	198	151	7	f701d06e3d7fd2192afae3698c5ec3c355e96da3
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_NK-Cycling_NK\|lymph-node_spleen / Manually curated celltypes from each tissue	ZGRF1 KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	5.19e-06	198	151	7	b2868a897dd96494cf1829c30e0ce508f52efdf3
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Stem_cells-Neuroepithelial_cell\|2m / Sample Type, Dataset, Time_group, and Cell type.	KIF20A BRCA2 FANCI BUB1B HASPIN CEP135 NEIL3	5.55e-06	200	151	7	0d9b8d51a7630e70e60c76c763ff82df4c559152
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Stem_cells\|2m / Sample Type, Dataset, Time_group, and Cell type.	KIF20A BRCA2 FANCI BUB1B HASPIN CEP135 NEIL3	5.55e-06	200	151	7	0675f580ccef705875854247bbfd4ee2bcf126a1
ToppCell	LPS_only-Endothelial-Endothelial-FOXM1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZGRF1 KIF20A BRCA2 KCNJ5 BUB1B NEIL3	6.52e-06	134	151	6	4d8f7ddad02fe76a614771e115ebb8e04623ba85
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI1 MBOAT1 ADAMTSL3 BPIFA2 KCNJ6 DNAH11	1.07e-05	146	151	6	ec1f793409d1a81c0f9323eb3c82ffe01dae0e44
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 ZNF273 BRCA2 KIAA0825 FANCI DNAH11	1.61e-05	157	151	6	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	1.99e-05	163	151	6	3f434015c0cbefb31eeda133c34f75384c5f7e22
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	COL6A3 IL31RA MXRA5 EGR4 MICAL2 PLPP4	2.06e-05	164	151	6	9b4a6007abae992db871d9f6f731d5af724de30d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BRCA2 FANCI BUB1B NEIL3 STOML3	2.28e-05	167	151	6	bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFAP91 ZGRF1 CHRNA3 BRCA2 FANCI BUB1B	2.44e-05	169	151	6	121768fc51fc3441ec725346a1bbe29e21d05971
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	2.44e-05	169	151	6	54b13ab02b4c187f4754045ecfcf409749e7ccc0
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ATP13A1 TRRAP ADCY3 TASOR2 FOCAD ALCAM	2.69e-05	172	151	6	da959c1abadafd79b7a0088a25eb8ef8efa3a0c2
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELAPOR2 DENND4A ITGAD SLC24A2 KCNJ5 ZFHX2	2.87e-05	174	151	6	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OR2T2 ITGAD SLC7A11 IGHE RNF145 DNAH11	2.87e-05	174	151	6	16204ff504b7b382b4d90ca35003ad5336020e07
ToppCell	Dividing_Macrophages-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	CCDC168 KIF20A BRCA2 FANCI BUB1B NEIL3	2.97e-05	175	151	6	0a8bf455babb3271aa00642199fb58b0b02dc3ac
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	2.97e-05	175	151	6	876cea684faf42ff3eb4623ad6d7a1fb1276ee02
ToppCell	facs-Skin-Anagen-24m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A LINGO1 BUB1B HASPIN NEIL3 DNAH8	3.16e-05	177	151	6	8a0f0fbb06cdacb99a3fdba0da3e0494b891db4f
ToppCell	facs-Skin-Anagen-24m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A LINGO1 BUB1B HASPIN NEIL3 DNAH8	3.16e-05	177	151	6	e9d7682517fb30fd2ad535d59779d718a7024c13
ToppCell	Dividing_Macrophages-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	KIF20A AGXT2 BRCA2 FANCI BUB1B NEIL3	3.26e-05	178	151	6	1893fadac2ec3d5de0a641e57b7b2f962012a9ba
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	WFS1 KIF20A BRCA2 BUB1B HASPIN NEIL3	3.37e-05	179	151	6	021d782134126c6f7dce6b6ea50cc54bdaa39987
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INTS1 ITGAD FANCI BUB1B NEIL3 PWWP3B	3.81e-05	183	151	6	42dc31d587fbb9724b2f0be5ee8ed77233f67b86
ToppCell	droplet-Spleen-nan-24m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZGRF1 NBEA ZDHHC15 BUB1B NEIL3 DNAH11	3.93e-05	184	151	6	b998803180322a5ea2b567928dea531c26816c3c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	4.05e-05	185	151	6	30e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	CFAP47 CFAP91 DCDC1 ZNF273 ZFHX2 DNAH11	4.05e-05	185	151	6	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	368C-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZGRF1 KIF20A TMEM156 GZMA BUB1B IL19	4.17e-05	186	151	6	799903b68bc6f6205d004b44c603424b0d5f7c32
ToppCell	facs-Skin-Telogen-3m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A FANCI BUB1B HASPIN NEIL3 DNAH8	4.17e-05	186	151	6	9feef5936985e936b3d88f9d1bb012abb6468570
ToppCell	facs-Skin-Telogen-3m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A FANCI BUB1B HASPIN NEIL3 DNAH8	4.17e-05	186	151	6	89f5b06bc56674af304912d481ac697c7c870904
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL6A3 CRIM1 NBEA ADAMTSL3 ADCY3 KCNJ6	4.30e-05	187	151	6	fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ELAPOR2 WFS1 DIPK2B FBN1 MICAL2	4.30e-05	187	151	6	65d406122dffe18279f14a1ed35ba091730b97be
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	4.30e-05	187	151	6	9351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	4.30e-05	187	151	6	057569c9437219ecc396aa6e673b1178a2273837
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ELAPOR2 WFS1 DIPK2B FBN1 MICAL2	4.30e-05	187	151	6	4c15c0ed41a55271fc793cb76fee97fa64190369
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ELAPOR2 WFS1 DIPK2B FBN1 MICAL2	4.30e-05	187	151	6	5274f2b302bbf7fed30c480af4f35058d2cf61e0
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ELAPOR2 WFS1 DIPK2B FBN1 SNCAIP	4.43e-05	188	151	6	26915db8863f4115b46a81982e187322e21600fd
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ELAPOR2 WFS1 DIPK2B FBN1 SNCAIP	4.43e-05	188	151	6	3f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ELAPOR2 WFS1 DIPK2B FBN1 SNCAIP	4.43e-05	188	151	6	61ee7b152745164293d8a44ef91ee2393efbdca5
ToppCell	Control-Endothelial-Endothelial-FOXM1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	4.56e-05	189	151	6	1e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-Cycling_Natural_Killer_Cell_/_Natural_Killer_T_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BRCA2 FANCI GZMA BUB1B NEIL3	4.70e-05	190	151	6	185ae04c68f825cd346aa65072cc5da6a39dff4a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-Cycling_Natural_Killer_Cell_/_Natural_Killer_T_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BRCA2 FANCI GZMA BUB1B NEIL3	4.70e-05	190	151	6	e38dc41f2e79e3bd51326581c6ebe51927edb549
ToppCell	Dividing_Macrophages-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	KIF20A BRCA2 FANCI BUB1B SCN10A NEIL3	4.84e-05	191	151	6	3e567ed6b5fefafa7f460e49d25d60bb52a0a6c8
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	COL6A3 NHSL2 ADAMTSL3 ADCY3 FBN1 MICAL2	4.84e-05	191	151	6	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAGI1 MBOAT1 ADAMTSL3 BPIFA2 SHOC1	4.93e-05	117	151	5	240cd636d1f5d3f270825ace02126fae993f5802
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	COL6A3 DENND4A DGKA ANKRD44 RRP12 ATM	4.98e-05	192	151	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MAGI1 ELAPOR2 ITPR3 MICAL2 TLR2 ALCAM	4.98e-05	192	151	6	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	Control-Lymphoid-Proliferating_CD4_T_cells\|Control / Condition, Lineage and Cell class	KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	5.12e-05	193	151	6	33d409d6ed1c606337248587ad997ac5f67f081d
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 CFAP91 DCDC1 ZNF273 SLC25A36 DNAH11	5.12e-05	193	151	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ZGRF1 DACH2 BRCA2 FANCI BUB1B NEIL3	5.12e-05	193	151	6	516ea2c12bdc7a5dc676159d627e36f6abe13ef0
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	5.27e-05	194	151	6	f9070035553bc68106a9e0bdf4b507715a138aba
ToppCell	3'_v3-blood-Lymphocytic_NK-Cycling_NK\|blood / Manually curated celltypes from each tissue	ZGRF1 BRCA2 FANCI GZMA BUB1B HASPIN	5.27e-05	194	151	6	bf9734abaad603ade2a6a6940918aaf1e1c4e2cd
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 CFAP91 DCDC1 NBEA SHOC1 DNAH11	5.27e-05	194	151	6	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-J_(AT1-AT2_progenitors)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	5.27e-05	194	151	6	4d6ae2b25db11a4ae6dadee83be5c8c05b1225c3
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	5.43e-05	195	151	6	926eb3fc5d028be936885bea0654a77db3107234
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	5.43e-05	195	151	6	75759fd7f925725f0ecd07214afcca5aa2158f9e
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	5.43e-05	195	151	6	1a5e814e12fe37287dbfc58189e1958e2c76b5da
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_1\|343B / Donor, Lineage, Cell class and subclass (all cells)	KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	5.43e-05	195	151	6	47a01b8a92eebeb34ac7f70bf1ab4613a326e24f
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	5.58e-05	196	151	6	9591a6a3477ed6a1e2e016f7542e38603d8b16cb
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	5.58e-05	196	151	6	1d2e0b328eb822db7521b5f5724d4bd17c0bad5f
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	5.58e-05	196	151	6	1964c5003a0cb84539850a7cfe3bbb0e23a61d2d
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	5.58e-05	196	151	6	73f951f7712e0aa3323676b9a4b7944d21d347c4
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_interstitial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	OTOA ATG7 FANCI TMLHE TLR2 HCRTR1	5.58e-05	196	151	6	e12fc1bfeb42457b204d582d3e19f01e2345cb6a
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	5.74e-05	197	151	6	84ed777cdba569200a3ef1654d8a12f17fcfb7f1
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 CFAP91 DCDC1 DIAPH2 STOML3 DNAH11	5.74e-05	197	151	6	71fea4aa6ce96c7693fa94792d08770622873850
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 CFAP91 DCDC1 KIAA0825 ZFHX2 DNAH11	5.74e-05	197	151	6	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BRCA2 FANCI GZMA BUB1B HASPIN NEIL3	5.74e-05	197	151	6	7eb4c1cffd0366204af7e63adc8f751685601a94
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	5.74e-05	197	151	6	8b616cde333bdbc0c591035ad9e4949155866245
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NBEA CHRNA3 KCNJ6 ZFHX2 SV2C PLPP4	5.91e-05	198	151	6	85881637641d8996be2edc65c4bceff0433135e7
ToppCell	COVID-19_Moderate-T/NK_proliferative\|COVID-19_Moderate / disease group, cell group and cell class	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	5.91e-05	198	151	6	166c000fb0e19602ffdd8bf2b2f19be2c6df96a6
ToppCell	severe_COVID-19-T/NK_proliferative\|severe_COVID-19 / disease group, cell group and cell class (v2)	ZGRF1 BRCA2 FANCI GZMA BUB1B HASPIN	5.91e-05	198	151	6	ed86b0247006befe55400c287d334d2202b470bd
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-Cycling_Natural_Killer_Cell_/_Natural_Killer_T_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BRCA2 FANCI GZMA BUB1B NEIL3	5.91e-05	198	151	6	d484ac79d6cd29f1d9c192d126c2099f737d5320
ToppCell	COVID-19_Moderate-T/NK_proliferative\|World / disease group, cell group and cell class	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	5.91e-05	198	151	6	bf0131fbca6032e1aab4aa807f8c1d3be689cb7f
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-Cycling_Natural_Killer_Cell_/_Natural_Killer_T_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A BRCA2 FANCI GZMA BUB1B NEIL3	5.91e-05	198	151	6	ac0be1666456cfa8d68588b187d65008e6d5c0e2
ToppCell	distal-1-Hematologic-Proliferating_Macrophage\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	5.91e-05	198	151	6	df3f5559ecd1f3cd1fd60e39dbad8741309e83a3
ToppCell	distal-Hematologic-Proliferating_Macrophage-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	5.91e-05	198	151	6	2b0716e900bce54ad1825d6dcdaf4ebf31f355c4
ToppCell	(0)_NK_dividing\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	KIF20A BRCA2 FANCI GZMA BUB1B NEIL3	5.91e-05	198	151	6	c5336d9b802393d6fd6f8446ea4bb6befeb97bfd
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZGRF1 KIF20A BRCA2 FANCI BUB1B NEIL3	5.91e-05	198	151	6	bcfe7b6d91f2e2f145cb2660b65fd2a6c1134b86
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NUP214 KIF20A BRCA2 FANCI BUB1B NEIL3	6.07e-05	199	151	6	13ff6c26ebcc663ef8e5559ab9be99dab848abe7
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	KIF20A BRCA2 FANCI BUB1B HASPIN NEIL3	6.07e-05	199	151	6	88d130e2451e61afb710edf552e6b346b9fcfb2b
Drug	L-Cystine	SLC7A11 SLC3A1 SLC7A9 CTNS	1.67e-09	4	147	4	DB00138
Disease	cystinuria (is_implicated_in)	SLC3A1 SLC7A9	2.33e-05	2	143	2	DOID:9266 (is_implicated_in)
Disease	cystinuria (implicated_via_orthology)	SLC3A1 SLC7A9	2.33e-05	2	143	2	DOID:9266 (implicated_via_orthology)
Disease	Cystinuria	SLC3A1 SLC7A9	2.33e-05	2	143	2	cv:C0010691
Disease	CYSTINURIA	SLC3A1 SLC7A9	2.33e-05	2	143	2	220100
Disease	Cystinuria	SLC3A1 SLC7A9	2.33e-05	2	143	2	C0010691
Disease	cataract (implicated_via_orthology)	CRIM1 WFS1 INTS1 BRCA2	3.43e-05	38	143	4	DOID:83 (implicated_via_orthology)
Disease	Heart Block	KCNJ5 SCN10A	1.39e-04	4	143	2	C0018794
Disease	Auriculo-Ventricular Dissociation	KCNJ5 SCN10A	1.39e-04	4	143	2	C0004331
Disease	comparative body size at age 10, self-reported	MAGI1 ATG7 ADAMTSL3 ADCY3 FOCAD MFAP3 RPTOR KCNJ6 HCRTR2	2.19e-04	420	143	9	EFO_0009819
Disease	thoracic aortic aneurysm, Abdominal Aortic Aneurysm, brain aneurysm	ANKRD44 FBN1	3.45e-04	6	143	2	EFO_0003870, EFO_0004214, EFO_0004282
Disease	hip bone mineral density	MAGI1 CRIM1 SLC35A1 ALCAM DNAH11	3.80e-04	126	143	5	EFO_0007702
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	IQCN ADAMTSL3 ADCY3 HIVEP3 ANKRD44 MFAP3 RPTOR ALCAM	4.16e-04	364	143	8	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	Aortic Aneurysm, Thoracic	ROBO4 FBN1	4.82e-04	7	143	2	C0162872
Disease	Aortic Aneurysm, Thoracoabdominal	ROBO4 FBN1	4.82e-04	7	143	2	C0340630
Disease	infertility (implicated_via_orthology)	BRCA2 ATM	4.82e-04	7	143	2	DOID:5223 (implicated_via_orthology)
Disease	female breast cancer (is_implicated_in)	FANCI ATM	6.41e-04	8	143	2	DOID:0050671 (is_implicated_in)
Disease	type 1 diabetes mellitus (is_implicated_in)	WFS1 GC ITPR3 TLR2	7.90e-04	85	143	4	DOID:9744 (is_implicated_in)
Disease	waist-hip ratio, metabolic syndrome	KCNJ6 STOML3	8.21e-04	9	143	2	EFO_0000195, EFO_0004343
Disease	Liver carcinoma	ATG7 CYP39A1 DIPK2B KIF20A ISG15 FANCI BUB1B NEIL3 ATM	8.50e-04	507	143	9	C2239176
Disease	Fanconi anemia (is_implicated_in)	BRCA2 FANCI	1.02e-03	10	143	2	DOID:13636 (is_implicated_in)
Disease	pro‐interleukin‐16 measurement	ADAMTSL3 SLC24A2	1.25e-03	11	143	2	EFO_0010629
Disease	mammographic density measurement	NBEA ADAMTSL3 ADCY3	1.85e-03	50	143	3	EFO_0005941
Disease	Tobacco Dependence	CHRNA3 RPTOR	2.04e-03	14	143	2	C0040332
Disease	Fanconi anemia	BRCA2 FANCI	2.04e-03	14	143	2	cv:C0015625
Disease	atrial fibrillation (is_implicated_in)	AGXT2 KCNJ5	2.04e-03	14	143	2	DOID:0060224 (is_implicated_in)
Disease	phoneme awareness	ARFGEF2 KCNJ6	2.04e-03	14	143	2	EFO_0021812
Disease	Nicotine Dependence	CHRNA3 RPTOR	2.04e-03	14	143	2	C0028043
Disease	Nicotine Use Disorder	CHRNA3 RPTOR	2.04e-03	14	143	2	C0376384
Disease	Sinus Node Dysfunction (disorder)	KCNJ5 SCN10A	2.35e-03	15	143	2	C0428908
Disease	age at menarche	MYO1H ADCY3 CHRNA3 AGXT2 MFAP3 LINGO1 RPTOR SENP6 ASCC3	2.51e-03	594	143	9	EFO_0004703
Disease	Romano-Ward Syndrome	KCNJ5 SCN10A	2.68e-03	16	143	2	C0035828
Disease	body fat percentage	IQCN ADAMTSL3 ADCY3 HIVEP3 ANKRD44 MFAP3 RPTOR ALCAM	2.69e-03	488	143	8	EFO_0007800
Disease	Bone marrow hypocellularity	BRCA2 FANCI	3.39e-03	18	143	2	C1855710
Disease	Schizophrenia	MAGI1 GC CMYA5 ADAMTSL3 TRRAP CHRNA3 EGR4 TLR2 ATM HCRTR1 IL19	3.91e-03	883	143	11	C0036341
Disease	visual cortical surface area measurement	DCDC1 ALCAM	4.18e-03	20	143	2	EFO_0004771
Disease	Adenocarcinoma of prostate	BRCA2 ATM	4.18e-03	20	143	2	C0007112
Disease	Microcephaly	NUP214 TRRAP BUB1B	4.26e-03	67	143	3	C0025958
Disease	MYELODYSPLASTIC SYNDROME	BRCA2 FANCI TLR2	4.26e-03	67	143	3	C3463824
Disease	BREAST CANCER	BRCA2 ATM	4.61e-03	21	143	2	114480
Disease	Nephritis, Tubulointerstitial	SLC3A1 SLC7A9	4.61e-03	21	143	2	C0041349
Disease	gestational age	SLC7A11 HIVEP3 ANKRD44 HCRTR1	4.63e-03	138	143	4	EFO_0005112
Disease	Cocaine Dependence	CHRNA3 LRRC7 DNAH8 HCRTR1	4.75e-03	139	143	4	C0600427

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSIKCLQIPEKLELT	BUB1B	696	O60566
VITTPEIAKSLAKCL	AGXT2	361	Q9BYV1
VSDCPTLKTKLLVSD	ACSM6	176	Q6P461
VTQALAVLLECLESP	BRAT1	446	Q6PJG6
EKVTLCISVLLSLTV	CHRNA3	271	P32297
TQTLVKTFEVCDLPV	COPB2	46	P35606
KLFLECTLILTSVVP	ATP13A1	476	Q9HD20
VSLLLIPEDVCEKII	GZMA	16	P12544
PRVVSTSLDCLQKLI	ARFGEF2	81	Q9Y6D5
LEEEKLSCVPVLIFA	ARL3	111	P36405
IPESSLVQTLCVLLE	DNAH11	2371	Q96DT5
KPSIIAVTLACEELK	DIAPH2	811	O60879
KSEDDVLVVCPTILT	DHX29	416	Q7Z478
LPSCESISEKQSLVL	DIPK2B	346	Q9H7Y0
EKSKPCVSSILLEDL	CASP8AP2	1426	Q9UKL3
TKLKRLDISPVVCTV	DACH2	111	Q96NX9
ATLILDSLIQCPIDT	ACTR10	281	Q9NZ32
VCQDSIPELLTLATL	CFAP91	211	Q7Z4T9
LAVTDICIIIPSKGE	DENND4A	156	Q7Z401
ILEEQKTILPVTSCF	RC3H2	1126	Q9HBD1
VATILKTLCLASPTV	IQCN	511	Q9H0B3
FPLNLCTKTIVETIR	PARP9	246	Q8IXQ6
KCTSLLPLEDVVSVV	ITPR3	1386	Q14573
VITEKCPEGIILLLV	KCNJ5	156	P48544
PISLAVPKETDCLLT	PAPOLB	26	Q9NRJ5
CAINITEIPLIKISE	OTOA	971	Q7RTW8
APTVCLLVLSQAEKV	FANCI	1081	Q9NVI1
TVPTITLLLEECTEK	DCDC1	191	M0R2J8
EIPAVLKLSCTDTSL	OR2T2	181	Q6IF00
DELPASILCGIVSVK	FMO3	286	P31513
LVECPKGSEVTLLVQ	MAGI1	706	Q96QZ7
AVSIVISKLPTVIAC	KIAA0825	971	Q8IV33
SPVLEVQLTKDLICF	NEIL3	116	Q8TAT5
ACKPVVVVSSLLLQE	INTS1	1576	Q8N201
CSTPSDKLVIDKLVV	IL31RA	596	Q8NI17
VEKLALTTSGCPLVI	MTMR6	56	Q9Y217
CLTIIEASVNPISKL	LRRC7	116	Q96NW7
SLALVASKLCEETPI	GMIP	886	Q9P107
TDKCPEGIILLLIQS	KCNJ6	161	P48051
STLETLQIIKPLDVC	IL19	61	Q9UHD0
VLLVVDKCDEPLSIL	ISG15	71	P05161
KVVLAPCIETLILLD	METTL25	551	Q8N6Q8
VTGEIKVILIECSEL	IL1RAPL1	501	Q9NZN1
LPALVKIACVDTTTV	OR2W1	181	Q9Y3N9
VVDSIFCDLPLVTKL	OR4K17	176	Q8NGC6
LTIKAEECASIPTLL	DNAH8	2671	Q96JB1
SAAVQILLEICLPTE	INTS2	936	Q9H0H0
ITDPDILKTCVPDLS	DGKA	636	P23743
LELPALLQSIDCKVS	NANP	231	Q8TBE9
VLQVTETVKVCATLP	NUP214	176	P35658
LTLEKCNLTSIPTEA	LINGO1	196	Q96FE5
KCAEVIIPLLSSVNV	ANKRD44	121	Q8N8A2
TKIEDLLSISCPAEL	EGR4	341	Q05215
PLLELSCSDTSLIEK	OR2AP1	181	Q8NGE2
PSLKAACIDTSILEL	OR6X1	181	Q8NH79
AISFLTPLAVICVVK	PLPP4	56	Q5VZY2
ISLPEKKLATCETVD	ELAPOR2	911	A8MWY0
TTVVEKLQLCLPVLE	EXOC6	126	Q8TAG9
IIAKEGTSVSIECLL	MFAP3	61	P55082
PILQLSCTDTDIIEL	OR6C74	181	A6NCV1
DIIPLLKISCTDSSI	OR5H6	196	Q8NGV6
TLKLLLPDCVEDVVS	ITGAD	711	Q13349
ICLTTTTVPKILVNI	OR7G1	71	Q8NGA0
VVISITIFCLETLPE	KCNA10	226	Q16322
TAICLPASLLVDITE	HCRTR1	96	O43613
VLVTITCLPATLVVD	HCRTR2	101	O43614
TVECLPLVEKLFSDL	CEP135	26	Q66GS9
TLIAVVLSCSPICEK	ATM	1156	Q13315
PTLDLDKVVSVKCLL	ATG7	346	O95352
STVSSLLQKEICPLI	BPIFA2	206	Q96DR5
LELACETIEITAAPK	BRCA2	1576	P51587
STLDPTKTICIETIK	FBN1	836	P35555
SLIVIKPTSFAIICL	SLC7A9	116	P82251
LVEKTKTFLPVVLSC	CMYA5	2716	Q8N3K9
TEPLALTETDICKLP	COL6A3	3101	P12111
SLDSIASVVVPIIIC	CRIM1	936	Q9NZV1
SETVLALVNCISPLK	DENND6A	306	Q8IWF6
VVLLCTALVEILIDP	ADCY3	641	O60266
IIISKELSLLSGEVC	HASPIN	536	Q8TF76
LTLTKTFPVTCLVDD	MBOAT1	256	Q6ZNC8
IRKSPTITCLVVDLA	IGHE	231	P01854
CVLETIRLKAPGVIT	CYP39A1	331	Q9NYL5
LVEKCESSVSLTVPP	CTNS	16	O60931
EIVVLLSKTCPFVTS	CCDC168	4686	Q8NDH2
KLSDVTLVPVSCSEL	DDAH2	251	O95865
SKIIISPEENVTLTC	ALCAM	471	Q13740
IKNIDTTIIISCLPN	CFAP47	316	Q6ZTR5
TEGTCKLLTLVVTDL	MFSD13A	371	Q14CX5
ALSLLVPVFIISCKE	FOCAD	1046	Q5VW36
CSKIEDVPTLLEKVS	MICAL2	1626	O94851
VPALLKLACVDTTVN	OR2G3	181	Q8NGZ4
SPVLIVDLLCDKKTI	OR4A8	76	P0C604
ICFSSITVPKVLVDL	OR4D10	71	Q8NGI6
DVDLVCITVTEKLPF	RPP30	121	P78346
AKLVDLPCVIESLRT	TAF7L	151	Q5H9L4
TAVCITEVIKLLLSV	SLC35A1	46	P78382
LDPTCTIKTPEITVS	UTP15	381	Q8TED0
TKSIPILLASTVLVC	SV2C	696	Q496J9
TKVCPVLIELTAPDS	PPP4R1	171	Q8TF05
EISEVSPQSLCLVLV	TDRD15	1801	B5MCY1
LPLSPIITLEEDTKC	NHSL2	1031	Q5HYW2
VSVLLEDRILTCPVS	SLC24A2	646	Q9UI40
ILEVLLPEAIICSIS	PWWP3B	636	Q5H9M0
ILKSLVAAPVEIAEC	NBEA	1746	Q8NFP9
VLTEEELTTTLKVLC	SETD6	361	Q8TBK2
IEIFLPTKVLQLESC	SHOC1	396	Q5VXU9
LSTEETEISPPLVKC	SNCAIP	231	Q9Y6H5
LSRKVTSLVPESCLL	SLC9A5	66	Q14940
IAATIAIIALSPKCL	SLC3A1	101	Q07837
AILTCPLEVVKTRLQ	SLC25A36	21	Q96CQ1
SLLDIVLCLTVIPKV	OR56A3	71	Q8NH54
QKCVSLVPGVTLDLI	RPTOR	281	Q8N122
TALIPEVILCTKEVS	RRP12	856	Q5JTH9
SVLTPEEVALCLELS	ROBO4	791	Q8WZ75
SSLEECPIPKVLISV	SMCR8	401	Q8TEV9
LKPECSTEELLSILS	ASCC3	1836	Q8N3C0
SVLLQVPFTCTIITK	CNBD1	406	Q8NA66
KTPKERTLELSCLEV	TMEM156	26	Q8N614
IQCEIPELAIKLITA	SLC7A11	156	Q9UPY5
LGIAVSKPDLITCLE	ZNF273	76	Q14593
PECVEKLLLVATTVE	ZFHX2	1036	Q9C0A1
LVAIICDILGEKTTS	SLC16A4	76	O15374
PTTVNVCSELVKLVF	SLC35A5	51	Q9BS91
DIVPKISELSLCDLA	KIF20A	396	O95235
LVTDPFAELTITLCI	SCN10A	661	Q9Y5Y9
SEAKDITCLSLLPVT	ZNF410	31	Q86VK4
VLPCIDVFVKVDLRT	STOML3	81	Q8TAV4
LSISTEVKKSIDIPC	TRGV10	26	A0A0A0MS01
KLELVKPCSVVLTST	HIVEP3	1461	Q5T1R4
VLPLAEDITNILSKC	GC	251	P02774
ELTAEPTIVAQLCKV	THTPA	81	Q9BU02
PSDQVILIARKTCLL	TEX11	671	Q8IYF3
PVEIILNTSDLTKCE	SENP6	481	Q9GZR1
KLCPTLIPTTDEIFL	UBE2U	251	Q5VVX9
VVLCESPQDKRTLLV	TBC1D15	181	Q8TC07
DFSVPLIIDIKCTKL	CAD	1421	P27708
VFLGIVVTKPDLITC	ZNF90	41	Q03938
LKFPVVVLDECSQIT	ZGRF1	1801	Q86YA3
KVIPILSTLNCALLE	TASOR2	176	Q5VWN6
PVTLILSKENCTLEI	TASOR2	1366	Q5VWN6
ILKEPTTESLQALCA	TTC37	1116	Q6PGP7
PALTISKVLLSICSL	UBE2E1	141	P51965
CLVPLETIVIINKFA	RNF145	161	Q96MT1
ITVENSKVFLVPCLL	TLR2	341	O60603
VTGCIPKTLEILDVS	TLR2	451	O60603
DLCIKPKTIRLDETT	TMLHE	101	Q9NVH6
TCSEVFQKPIVLRIL	THEGL	26	P0DJG4
IELLLAVCEKSTPIG	TRRAP	2496	Q9Y4A5
TLKETPASVLELVIC	ZDHHC18	271	Q9NUE0
LLVVQETKTCPLDLL	ZBTB40	536	Q9NUA8
FELCLVTVLSPAEKV	ZDHHC15	41	Q96MV8
KIAVTVAVCSVPLLL	WFS1	596	O76024
KRTEVINILCDLITP	ADAMTSL3	1206	P82987
KTEEVICPLTLELSV	MYO1H	326	Q8N1T3
LVSIINGETLKLPCT	MXRA5	2646	Q9NR99