Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ABCA2 GTF3C2 VWA8 INPP5E LARS1 AKNA HMGXB3 HHIPL1 DOCK6 FRMD4B	3.87e-07	529	80	10	14621295
Pubmed	Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells.	CSK KDR BCAR1	2.54e-06	12	80	3	9621077
Pubmed	RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells.	GTF3C2 CSK LARS1 SCRIB	4.29e-06	47	80	4	29212245
Pubmed	VEGFR2 expression and TGF-β signaling in initial and recurrent high-grade human glioma.	TGFB1 KDR	5.23e-06	2	80	2	21985798
Pubmed	Dual roles of the C-terminal Src kinase (Csk) during developmental vascularization.	CSK KDR	5.23e-06	2	80	2	14576066
Pubmed	beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.	ARRB1 CSK	5.23e-06	2	80	2	10753943
Pubmed	Apoptosis of pulmonary microvascular endothelial cells stimulates vascular smooth muscle cell growth.	TGFB1 KDR	5.23e-06	2	80	2	16617095
Pubmed	Children undergoing liver transplantation for treatment of inherited metabolic diseases are prone to higher oxidative stress, complement activity and transforming growth factor-β1.	TGFB1 C5	5.23e-06	2	80	2	23792503
Pubmed	Fibrotic mechanisms in idiopathic rapidly progressive glomerulonephritis: the role of TGF-beta1 and C5b-9.	TGFB1 C5	5.23e-06	2	80	2	18300128
Pubmed	Slit2 Promotes Angiogenic Activity Via the Robo1-VEGFR2-ERK1/2 Pathway in Both In Vivo and In Vitro Studies.	SLIT2 KDR	5.23e-06	2	80	2	26244297
Pubmed	p130Cas controls the susceptibility of cancer cells to TGF-β-induced growth inhibition.	TGFB1 BCAR1	5.23e-06	2	80	2	23872147
Pubmed	Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice.	TGFB1 KDR	1.57e-05	3	80	2	7600998
Pubmed	Regulation of c-Src by binding to the PDZ domain of AF-6.	CSK AFDN	1.57e-05	3	80	2	17491594
Pubmed	β-Arrestin-1 directly interacts with Gαs and regulates its function.	ARRB1 GNAS	1.57e-05	3	80	2	23353685
Pubmed	Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion.	BCAR1 PRDM1	1.57e-05	3	80	2	28442738
Pubmed	AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation.	TGFB1 PRKAB1	1.57e-05	3	80	2	18250161
Pubmed	The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.	AFDN SCRIB FRMD4B	1.75e-05	22	80	3	27521426
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	UBR1 ATXN2L GTF3C2 VWA8 DHX40 EXD2 POLG IMMP1L	2.49e-05	515	80	8	31617661
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ATXN2L ARHGEF10 INPP5E AFDN TRIM68 SCRIB GNAS BCAR1 DOCK6 SHKBP1	2.83e-05	861	80	10	36931259
Pubmed	Immunolocalizations of VEGF, its receptors flt-1, KDR and TGF-beta's in epithelial ovarian tumors.	TGFB1 KDR	3.13e-05	4	80	2	16835828
Pubmed	p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity.	TGFB1 BCAR1	3.13e-05	4	80	2	19822523
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	SLIT2 ATXN2L TRIM11 WARS1 ABI2 NOM1 VPS4B STAU2 SCRIB	3.49e-05	704	80	9	32994395
Pubmed	Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage.	ERBB3 GNAS	5.20e-05	5	80	2	28414273
Pubmed	Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.	TGFB1 C5	5.20e-05	5	80	2	20479942
Pubmed	Aphidicolin-resistant and -sensitive base excision repair in wild-type and DNA polymerase beta-defective mouse cells.	POLG POLL	5.20e-05	5	80	2	15177179
Pubmed	Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells.	CSK BCAR1	5.20e-05	5	80	2	10739664
Pubmed	Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis.	AFDN KDR	7.79e-05	6	80	2	10477764
Pubmed	The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation.	AFDN KDR	7.79e-05	6	80	2	25893857
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	TGFB1 SLIT2 EDEM3 WARS1 TAF9B UBE2T RBM10 EXD2 STAU2 KIAA1143	1.04e-04	1007	80	10	34597346
Pubmed	A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk.	ERBB3 KDR	1.09e-04	7	80	2	20446891
Pubmed	c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms.	ARRB1 CSK	1.09e-04	7	80	2	19262695
Pubmed	Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab.	TGFB1 ERBB3	1.09e-04	7	80	2	18625725
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	UBR1 ERBB3 DHX40 NOM1 LRCH4 L2HGDH AFDN SCRIB	1.27e-04	650	80	8	38777146
Pubmed	Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization.	SLIT2 KDR	1.45e-04	8	80	2	26659946
Pubmed	Robo4 is a vascular-specific receptor that inhibits endothelial migration.	SLIT2 KDR	1.45e-04	8	80	2	12941633
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ERBB3 ABCA2 ARRB1 WARS1 ARHGEF10 POLG LARS1 AFDN TRIM68 SCRIB FRMD4B	1.70e-04	1285	80	11	35914814
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	SLIT2 DHX40 NOM1 KDR OVCH1	2.11e-04	234	80	5	36243803
Pubmed	TGF-beta1 perturbs vascular development and inhibits epithelial differentiation in fetal lung in vivo.	TGFB1 KDR	2.32e-04	10	80	2	11458389
Pubmed	Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.	TGFB1 KDR	2.32e-04	10	80	2	21282641
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	SLC6A6 ERBB3 ABI2 TMEM199 SCRIB GNAS	2.38e-04	377	80	6	38117590
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	WARS1 VWA8 DHX40 RBM10 AFDN SHKBP1	2.42e-04	378	80	6	34315543
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	ATXN2L CSK AFDN SCRIB	2.58e-04	133	80	4	15144186
Pubmed	Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia.	TGFB1 KDR	2.84e-04	11	80	2	15548578
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	GTF3C2 EXD2 GNAS ATP4A	3.05e-04	139	80	4	25476789
Pubmed	Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.	TGFB1 CSK NOX5 NCF2	3.22e-04	141	80	4	20056178
Pubmed	GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.	TGFB1 SLIT2 KDR	3.47e-04	59	80	3	21421844
Pubmed	Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice.	TGFB1 KDR	4.01e-04	13	80	2	11509733
Pubmed	Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning.	AEBP1 KDR	4.01e-04	13	80	2	29618843
Pubmed	Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells.	ERBB3 NKX6-1	4.01e-04	13	80	2	18036209
Pubmed	Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex.	WARS1 LARS1	4.01e-04	13	80	2	11829477
Pubmed	Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction.	SLIT2 NKX6-1	4.67e-04	14	80	2	25530182
Pubmed	Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.	ERBB3 KDR	4.67e-04	14	80	2	33500353
Pubmed	p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance.	WARS1 LARS1	4.67e-04	14	80	2	12060739
Pubmed	Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.	TGFB1 NKX6-1	4.67e-04	14	80	2	16435884
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	VWA8 DHX40 POLG VPS4B L2HGDH GNAS	5.28e-04	438	80	6	32628020
Pubmed	PDZ-Containing Proteins Targeted by the ACE2 Receptor.	SCRIB SHANK3	5.38e-04	15	80	2	34835087
Pubmed	Angiopoietin-1 is essential in mouse vasculature during development and in response to injury.	TGFB1 KDR	5.38e-04	15	80	2	21606590
Pubmed	Phenotypic analysis of mice completely lacking netrin 1.	SLIT2 KDR	5.38e-04	15	80	2	26395479
Pubmed	Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway.	TGFB1 KDR	5.38e-04	15	80	2	20692235
Pubmed	CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.	TGFB1 CHST5 SLC35B4 VPS4B GNAS PRDM1	5.41e-04	440	80	6	35156780
Pubmed	Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.	GZF1 CSK AFDN SCRIB BCAR1	5.89e-04	293	80	5	31741433
Pubmed	Genetic influences on the end-stage effector phase of arthritis.	NCF2 C5	6.14e-04	16	80	2	11489951
Pubmed	The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm.	TGFB1 KDR	6.14e-04	16	80	2	11124112
Pubmed	The ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling.	INPP5E NKX6-1	6.14e-04	16	80	2	31964774
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ARRB1 GZF1 GTF3C2 ABI2 DHX40 NOM1 EXD2 STAU2 LRCH4 AFDN SHKBP1	6.20e-04	1497	80	11	31527615
Pubmed	Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon.	TGFB1 PRKAB1 PER1	6.75e-04	74	80	3	26332085
Pubmed	An important role of endothelial hairy-related transcription factors in mouse vascular development.	SLIT2 KDR	6.95e-04	17	80	2	25264302
Pubmed	Expression levels of endoglin distinctively identify hematopoietic and endothelial progeny at different stages of yolk sac hematopoiesis.	TGFB1 KDR	6.95e-04	17	80	2	23712751
Pubmed	Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.	TGFB1 KDR	6.95e-04	17	80	2	25138534
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TGFB1 SLC6A6 ERBB3 SLC35B4 TMEM199 IMMP1L L2HGDH C5 DOCK6	7.38e-04	1061	80	9	33845483
Pubmed	Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development.	KDR GNAS	7.81e-04	18	80	2	25977369
Pubmed	Chloride intracellular channel 4 is required for maturation of the cerebral collateral circulation.	TGFB1 KDR	7.81e-04	18	80	2	26276819
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	ATXN2L GZF1 GTF3C2 NOM1 STAU2 LARS1 GNAS	7.88e-04	655	80	7	35819319
Pubmed	Phosphotyrosine interactome of the ErbB-receptor kinase family.	ERBB3 CSK	8.71e-04	19	80	2	16729043
Pubmed	Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta.	KDR PRDM1	8.71e-04	19	80	2	22987638
Pubmed	ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.	AFDN SCRIB	8.71e-04	19	80	2	35177595
Pubmed	Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects.	TGFB1 KDR	8.71e-04	19	80	2	25958091
Pubmed	Wnt7b is required for epithelial progenitor growth and operates during epithelial-to-mesenchymal signaling in pancreatic development.	NKX6-1 SCRIB	8.71e-04	19	80	2	25576928
Pubmed	Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain.	SLIT2 KDR	8.71e-04	19	80	2	21508241
Pubmed	The protein tyrosine kinase family of the human genome.	ERBB3 CSK KDR	9.43e-04	83	80	3	11114734
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	ATXN2L ABCA2 TAF9B GTF3C2 DHX40 NOM1 EXD2 LARS1 GNAS KIAA1143	9.64e-04	1335	80	10	29229926
Pubmed	GATA5 interacts with GATA4 and GATA6 in outflow tract development.	TGFB1 ERBB3	9.66e-04	20	80	2	21839733
Pubmed	Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line.	UBR1 C5	9.66e-04	20	80	2	17082620
Pubmed	A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development.	TGFB1 KDR	9.66e-04	20	80	2	12588999
Pubmed	Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways.	TGFB1 KDR	9.66e-04	20	80	2	18990706
Pubmed	Nuclear Organization in the Spinal Cord Depends on Motor Neuron Lamination Orchestrated by Catenin and Afadin Function.	AFDN NKX6-1	9.66e-04	20	80	2	29444423
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCA2 VWA8 INPP5E POLG PER1 AKNA POLL HMGXB3 DOCK6	9.82e-04	1105	80	9	35748872
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	ARHGEF10 INPP5E HMGXB3 SCRIB BCAR1	1.03e-03	332	80	5	37433992
Pubmed	Constitutive expression of TNF-alpha and -beta genes in mouse embryo: roles of cytokines as regulator and effector on development.	TGFB1 C5	1.07e-03	21	80	2	8138038
Pubmed	Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.	NOM1 PRKAB1	1.07e-03	21	80	2	25340873
Pubmed	Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells.	TGFB1 KDR	1.07e-03	21	80	2	21593423
Pubmed	Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells.	AFDN KDR	1.07e-03	21	80	2	18353970
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	ATXN2L GTF3C2 STAU2 AFDN SCRIB BCAR1	1.08e-03	503	80	6	16964243
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	SLC6A6 ABI2 AFDN SHANK3	1.13e-03	197	80	4	36604605
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	ATXN2L WARS1 VWA8 ABI2 STAU2 PER1 PITPNM3 AFDN SHANK3	1.21e-03	1139	80	9	36417873
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	VWA8 AFDN SCRIB ATP4A	1.24e-03	202	80	4	24639526
Pubmed	Netrin 1 directs vascular patterning and maturity in the developing kidney.	TGFB1 KDR	1.28e-03	23	80	2	37818607
Pubmed	Cranial neural crest deletion of VEGFa causes cleft palate with aberrant vascular and bone development.	TGFB1 KDR	1.28e-03	23	80	2	25759071
Pubmed	Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.	TGFB1 KDR	1.28e-03	23	80	2	28811219
Pubmed	Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex.	ABCA2 C5	1.28e-03	23	80	2	8799160
Cytoband	1q25	EDEM3 NCF2	9.48e-04	26	80	2	1q25
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UNC5A AFDN KDR BCAR1 DOCK6 FRMD4B SHANK3	3.76e-08	181	80	7	e898ecb8d8f2eb2204225b7b0d665cadcd241139
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UNC5A AFDN KDR BCAR1 DOCK6 FRMD4B SHANK3	4.54e-08	186	80	7	20340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UNC5A AFDN KDR DOCK6 FRMD4B SHANK3	8.31e-07	178	80	6	ad3de3e03a401dac64431a541899445262246347
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	AEBP1 INPP5E HPX L2HGDH TRIM68	1.24e-05	166	80	5	8d5d09f25e8903d481c2097fed435e69d42ccdb5
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-1\|TCGA-Liver / Sample_Type by Project: Shred V9	SLC6A6 UNC5A ARHGEF10 ABI2 PITPNM3	1.73e-05	178	80	5	51c59dabf2d7aef1b1964f6f766d5ec07ef90f5a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	QRFPR HPX KDR DOCK6 SHANK3	2.03e-05	184	80	5	688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC5A WARS1 TAF9B KDR DOCK6	2.09e-05	185	80	5	bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5A ARRB1 KDR TM6SF1 SHANK3	2.37e-05	190	80	5	876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5A ARRB1 KDR TM6SF1 SHANK3	2.37e-05	190	80	5	be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5A ARRB1 KDR TM6SF1 SHANK3	2.37e-05	190	80	5	09a8855901c3c9332dbaab3e40166485b696d0f1
ToppCell	background-Endothelial_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	SLC26A3 WARS1 HPX KDR SHANK3	2.68e-05	195	80	5	c7d60dabfc7cb310e002cab10003dadfcc34fe33
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A6 WARS1 KDR DOCK6 SHANK3	2.82e-05	197	80	5	cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-tip_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	AFDN KDR BCAR1 DOCK6 SHANK3	2.82e-05	197	80	5	b212ff28ca2d1fea4140f186ab90941bdca21249
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A6 WARS1 KDR DOCK6 SHANK3	2.82e-05	197	80	5	412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell	10x3'2.3-week_17-19-Endothelial\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	AFDN KDR BCAR1 DOCK6 SHANK3	2.89e-05	198	80	5	2630a7a6e56febe5c0b0bde70dd7292fa1650c47
ToppCell	10x5'v1-week_12-13-Endothelial-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	QRFPR KDR BCAR1 DOCK6 SHANK3	2.89e-05	198	80	5	122215d9288533ad03562cf777e846504863df9a
ToppCell	10x5'v1-week_12-13-Endothelial\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	QRFPR KDR BCAR1 DOCK6 SHANK3	2.89e-05	198	80	5	307dd09e6bc820a148f3000f18dae7aedba4be0b
ToppCell	COVID-19-lung-Capillary_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC26A3 WARS1 KDR DOCK6 SHANK3	2.89e-05	198	80	5	45419f2804b4be79bae6632e71c54e1af482d115
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	AFDN KDR BCAR1 DOCK6 SHANK3	2.89e-05	198	80	5	1e83bec16dcd60460422625f89952ff506d6be51
ToppCell	10x5'v1-week_14-16-Endothelial-stroma-tip_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	QRFPR KDR BCAR1 DOCK6 SHANK3	3.03e-05	200	80	5	77ac1aa73c16a4f595ff01c6b4e171e0b8fed1e6
ToppCell	COVID-19-COVID-19_Mild\|COVID-19 / Disease, condition lineage and cell class	TGFB1 WARS1 PER1 AKNA GNAS	3.03e-05	200	80	5	62c25042086f1afd1102e0720e933c2e476468fd
ToppCell	control-Myeloid-Monocyte-derived_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PER1 IMMP1L POLL SCRIB	1.39e-04	146	80	4	69e9c1ec6eec1151290227902e75e77a4aecc8db
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|368C / Donor, Lineage, Cell class and subclass (all cells)	UBR1 INPP5E AKNA TRIM68	1.46e-04	148	80	4	80470353e12599440f711b6e107730763376d04d
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CHST5 ERBB3 ARHGEF10 BCAR1	1.54e-04	150	80	4	70ac8ae4b1683fb17278a8e4606f2fa0b94988c0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TGFB1 PABPC5 TM6SF1 SHANK3	1.71e-04	154	80	4	1899138c096c08d8aee6b1970b7c0081e14c88a8
ToppCell	10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3\|bone_marrow / Manually curated celltypes from each tissue	CHST5 FGF20 KDR PCDH20	1.75e-04	155	80	4	83430a64c2cb5ad29caa3dacba76c28dd204ac40
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRD5 SLC26A3 KDR RNF17	1.75e-04	155	80	4	8fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARRB1 KDR SHANK3 PRDM1	1.93e-04	159	80	4	d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCell	NS-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TP53TG5 AEBP1 ST3GAL3 DOCK6	1.97e-04	160	80	4	8a4746463ca1976f7d6de803496c851249ced797
ToppCell	Control-APC-like-Monocytes\|Control / group, cell type (main and fine annotations)	TDRD5 ATXN2L INPP5E KIAA1143	2.12e-04	163	80	4	4bc80a2c741d462724b6f3902377d48c57478932
ToppCell	droplet-Pancreas-Endocrine-18m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFB1 AKNA NCF2 TM6SF1	2.12e-04	163	80	4	644c8a8af6a378fced4c70dec9a0de906f8d6e69
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TGFB1 KDR NCF2 GNAS	2.12e-04	163	80	4	c21114826bee1b05b411984326fef6b6e0d05316
ToppCell	droplet-Pancreas-Endocrine-18m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFB1 AKNA NCF2 TM6SF1	2.12e-04	163	80	4	aaff80d254131d1f1230bb12b6f43bc061ab5ab3
ToppCell	droplet-Pancreas-Endocrine-18m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFB1 AKNA NCF2 TM6SF1	2.12e-04	163	80	4	8b0f8a2d5b38f3bbff265211a7607acc85fa38b0
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TGFB1 KDR NCF2 GNAS	2.12e-04	163	80	4	5d49414432db259a19df50d7944581d00b69f537
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5A TM6SF1 FRMD4B SHANK3	2.17e-04	164	80	4	a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5A TM6SF1 FRMD4B SHANK3	2.17e-04	164	80	4	1a1795969673232191425dde84ab24ee6a98143f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5A TM6SF1 FRMD4B SHANK3	2.17e-04	164	80	4	8f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCell	Adult-Mesenchymal-myofibroblast_cell\|Adult / Lineage, Cell type, age group and donor	SLIT2 AEBP1 PABPC5 DOCK6	2.32e-04	167	80	4	d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TGFB1 ARRB1 KDR TM6SF1	2.54e-04	171	80	4	3112d15f2a28cf4a71992db4971d960716dc1264
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLIT2 AEBP1 NKX6-1 OVCH1	2.60e-04	172	80	4	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	droplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRD5 KDR HHIPL1 SHANK3	2.60e-04	172	80	4	073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CHST5 HPX SLC1A7	2.72e-04	70	80	3	986c7a1002a4ffd3a246495bedde2997ffdc2c9d
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CHST5 HPX SLC1A7	2.72e-04	70	80	3	c0330216305491d7d57cdbea0ae3cb8e9092c8e3
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P3\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CHST5 HPX SLC1A7	2.72e-04	70	80	3	86dde790fcdaec2095e2256463953077811145d2
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CHST5 HPX SLC1A7	2.72e-04	70	80	3	e604660b2efbc03e21806dcaecf7a72321673ae2
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	SLIT2 AEBP1 PABPC5 NKX6-1	2.84e-04	176	80	4	510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AKNA SLC1A7 SP140 PRDM1	2.84e-04	176	80	4	ce85a13e10cf37f5cf38ca8b0bac6701b6d00ffd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_26.46.91\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AEBP1 B4GALNT2 OVCH1 KIAA1143	2.84e-04	176	80	4	29b71369503719c74888cd356ceb6724cfdcabd9
ToppCell	ASK428-Epithelial-Secretory\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	TAF9B UBE2T SLC35B4 SP140	2.90e-04	177	80	4	66074a288501c136b4e83b883db5f0d8269ee326
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC26A3 TAF9B AEBP1 ST3GAL3	2.90e-04	177	80	4	88403b055eb9fdf96e4695fb6e0d78179e30a1e3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC26A3 TAF9B AEBP1 ST3GAL3	2.90e-04	177	80	4	8903aeaab61abd81a148ea623038c5114b8a183b
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	WARS1 HPX KDR SHANK3	2.96e-04	178	80	4	375156ba1c7b8592bf733c75f24968161f7cfa09
ToppCell	droplet-Pancreas-Endocrine-21m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFB1 NCF2 TM6SF1 SP140	3.09e-04	180	80	4	83f9060dcf1d0ff8d2b2edc1841b2624b81c0eb3
ToppCell	367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|367C / Donor, Lineage, Cell class and subclass (all cells)	ARHGEF10 KDR DOCK6 SHANK3	3.09e-04	180	80	4	162cec1734e560c068cd61717e40e18dcf92308c
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	WARS1 KDR DOCK6 SHANK3	3.09e-04	180	80	4	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	ARHGEF10 KDR DOCK6 SHANK3	3.09e-04	180	80	4	33c86c22ba877358cd8c1e39b5c0b3dc3a45b7dd
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	ARHGEF10 KDR DOCK6 SHANK3	3.16e-04	181	80	4	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	droplet-Lung-3m-Hematologic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TGFB1 CSK NCF2 TM6SF1	3.22e-04	182	80	4	6c06ee60f0f1bb2b8a97d978ef5a59d671f043a3
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	QRFPR KDR BCAR1 DOCK6	3.22e-04	182	80	4	997d37ca2af661c92a56add888762724dfccc890
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TGFB1 ARRB1 KDR TM6SF1	3.22e-04	182	80	4	345d0f9d5ee30434bc2aac17608ccdc9e61c8fa3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5A ARRB1 KDR FRMD4B	3.22e-04	182	80	4	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5A ARRB1 KDR FRMD4B	3.22e-04	182	80	4	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5A ARRB1 KDR FRMD4B	3.22e-04	182	80	4	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KDR DOCK6 FRMD4B SHANK3	3.29e-04	183	80	4	4d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	QRFPR AKNA FRMD4B PRDM1	3.29e-04	183	80	4	5a541a7f6c3514be8a13e988185dfe388c874f8b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.29e-04	183	80	4	93213124e55d1b673dd345188caf8b5bd31d99fe
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_KLHL14\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLIT2 QRFPR FRMD4B PRDM1	3.29e-04	183	80	4	439b1d1373b7cc73d65f3b59037a6def7cf8f4ba
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.36e-04	184	80	4	f6d6b3ddada66dae28d3306415bf4efe0934208a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	QRFPR OVCH1 FRMD4B PRDM1	3.36e-04	184	80	4	7f6c8912677764d438ab0555faca344d74c2f483
ToppCell	droplet-Mammary_Gland-nan-18m-Lymphocytic-B_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFB1 CSK NCF2 SP140	3.36e-04	184	80	4	73ddf9d647d61381bab1e9c0d983736b6d390c15
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	UNC5A KDR DOCK6 SHANK3	3.43e-04	185	80	4	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	UNC5A KDR DOCK6 SHANK3	3.43e-04	185	80	4	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.43e-04	185	80	4	1d731d69d8db8aef4a11439b8abd1030c7e6ac4c
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.43e-04	185	80	4	b8d02c9426740ffcb69d2e6f95473b388149d297
ToppCell	Control-Endothelial_cells-Endothelial_cells_(other)\|Control / group, cell type (main and fine annotations)	ARHGEF10 KDR DOCK6 SHANK3	3.50e-04	186	80	4	c6075fe84226b370c5139066793844ad33ae2db1
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.50e-04	186	80	4	90eaf6ffb4ce0c34fa1e79f0c8f36f217f44973b
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.50e-04	186	80	4	bd8a9753df219084e19e7f94447856e86608325c
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.57e-04	187	80	4	f0de86ef25e344d9b1860ee26308877d6c25ed31
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	WARS1 KDR DOCK6 SHANK3	3.57e-04	187	80	4	35c382c0aabd46906113e5db30ea24bb8e658899
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.57e-04	187	80	4	b71d0cd91bc98e020757c1d071a13ad48d718bcf
ToppCell	droplet-Fat-SCAT-30m-Endothelial-Cd36+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFDN KDR DOCK6 SHANK3	3.64e-04	188	80	4	e901a9bdf00b8e91806f445af66647373bf62661
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.64e-04	188	80	4	14072d0b82df55711d5356b2209f4f0bdd90dc27
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KDR BCAR1 DOCK6 SHANK3	3.64e-04	188	80	4	c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.64e-04	188	80	4	b04fd6a724c117eb9a979c29b91f90113feb7a5c
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	TGFB1 SLIT2 SHANK3 SLC1A7	3.64e-04	188	80	4	c90669b51e1902fe7726555290c91c92a911df83
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5A KDR BCAR1 TM6SF1	3.64e-04	188	80	4	26915db8863f4115b46a81982e187322e21600fd
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5A KDR BCAR1 TM6SF1	3.64e-04	188	80	4	3f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	UNC5A KDR BCAR1 TM6SF1	3.64e-04	188	80	4	61ee7b152745164293d8a44ef91ee2393efbdca5
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KDR BCAR1 DOCK6 SHANK3	3.64e-04	188	80	4	aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.72e-04	189	80	4	70eea8c94fa56bb15bee8065de47acea156794e9
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.72e-04	189	80	4	b60c8a29d3169c4830fe63b01db90c57660fc239
ToppCell	droplet-Heart-HEART-1m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 AFDN KDR GNAS	3.72e-04	189	80	4	4225bbff4037eecc93a12abad3a38dd04b1e22be
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(general)\|COVID-19 / group, cell type (main and fine annotations)	ARHGEF10 KDR DOCK6 SHANK3	3.79e-04	190	80	4	812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF10 STAU2 AFDN KDR	3.79e-04	190	80	4	474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCell	COVID-19-Endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	ARHGEF10 KDR DOCK6 SHANK3	3.79e-04	190	80	4	9fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLIT2 TM6SF1 FRMD4B PRDM1	3.79e-04	190	80	4	0acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB3 ABCA2 TP53TG5 FRMD4B	3.79e-04	190	80	4	396b7225c2430db3dc55a3d0db70239b71987229
ToppCell	10x5'v1-week_12-13-Endothelial-stroma-tip_EC\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	QRFPR KDR DOCK6 SHANK3	3.87e-04	191	80	4	cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCell	10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	KDR BCAR1 DOCK6 SHANK3	3.87e-04	191	80	4	dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
Drug	Sulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	CHST5 AEBP1 FGF20 PER1 POLL TRIM68 SLC1A7 PRDM1	4.64e-07	197	80	8	3940_UP
Drug	3-Acetamidocoumarin [779-30-6]; Up 200; 19.6uM; HL60; HT_HG-U133A	ATXN2L ABCA2 AFDN KDR DOCK6 SP140 PRDM1	5.88e-06	196	80	7	2941_UP
Disease	cerebellar ataxia (is_implicated_in)	POLG L2HGDH	7.04e-05	5	79	2	DOID:0050753 (is_implicated_in)
Disease	lung adenocarcinoma (is_implicated_in)	ERBB3 RBM10 PRDM1	3.11e-04	49	79	3	DOID:3910 (is_implicated_in)
Disease	mean arterial pressure	EDEM3 WARS1 CSK NOX5 L2HGDH GNAS BCAR1	3.85e-04	499	79	7	EFO_0006340
Disease	verbal-numerical reasoning measurement	ATXN2L ERBB3 EXD2 ST3GAL3	4.31e-04	131	79	4	EFO_0008394
Disease	Profound Mental Retardation	INPP5E L2HGDH GNAS SHANK3	5.39e-04	139	79	4	C0020796
Disease	Mental Retardation, Psychosocial	INPP5E L2HGDH GNAS SHANK3	5.39e-04	139	79	4	C0025363
Disease	Mental deficiency	INPP5E L2HGDH GNAS SHANK3	5.39e-04	139	79	4	C0917816
Disease	Colorectal Carcinoma	TGFB1 RBM10 ETFDH PER1 B4GALNT2 KDR GNAS SLC1A7	5.82e-04	702	79	8	C0009402
Disease	carcinoma (implicated_via_orthology)	ERBB3 KDR SCRIB	6.84e-04	64	79	3	DOID:305 (implicated_via_orthology)
Disease	Uremia	TGFB1 KDR	9.38e-04	17	79	2	C0041948
Disease	hepatocellular carcinoma (is_marker_for)	ERBB3 CSK RBM10 KDR PRDM1	1.30e-03	301	79	5	DOID:684 (is_marker_for)
Disease	urinary albumin to creatinine ratio	TGFB1 EDEM3 GTF3C2 ABI2	1.38e-03	179	79	4	EFO_0007778
Disease	Epilepsy, Cryptogenic	TGFB1 POLG L2HGDH	1.40e-03	82	79	3	C0086237
Disease	Awakening Epilepsy	TGFB1 POLG L2HGDH	1.40e-03	82	79	3	C0751111
Disease	Aura	TGFB1 POLG L2HGDH	1.40e-03	82	79	3	C0236018
Disease	breast cancer (is_marker_for)	TGFB1 L3MBTL1 KDR BCAR1	1.56e-03	185	79	4	DOID:1612 (is_marker_for)
Disease	impotence (biomarker_via_orthology)	TGFB1 KDR	1.58e-03	22	79	2	DOID:1875 (biomarker_via_orthology)
Disease	Epilepsy, Benign Psychomotor, Childhood	SLIT2 KDR	1.73e-03	23	79	2	C0393672
Disease	Epilepsy, Lateral Temporal	SLIT2 KDR	1.73e-03	23	79	2	C0393682
Disease	Uncinate Epilepsy	SLIT2 KDR	1.73e-03	23	79	2	C0014558
Disease	Epilepsy, Temporal Lobe	SLIT2 KDR	1.73e-03	23	79	2	C0014556
Disease	chronic obstructive pulmonary disease (is_marker_for)	TGFB1 KDR C5	2.27e-03	97	79	3	DOID:3083 (is_marker_for)
Disease	Pancreatic Neoplasm	TGFB1 KDR BCAR1	2.48e-03	100	79	3	C0030297
Disease	attention deficit hyperactivity disorder (implicated_via_orthology)	VPS4B PER1	2.56e-03	28	79	2	DOID:1094 (implicated_via_orthology)
Disease	Malignant neoplasm of pancreas	TGFB1 KDR BCAR1	2.62e-03	102	79	3	C0346647

Protein segments in the cluster

Peptide	Gene	Start	Entry
VPYRGRVAPILPAVV	TDRD5	121	Q8NAT2
PEKLPYLVELSPGRR	AFDN	381	P55196
RREEKYPLRGTDPLP	GNAS	306	P84996
DPPRYLVIKRESGPG	ERBB3	971	P21860
LYVPVEEKRREPGAP	ARHGEF10	961	O15013
VIPKLYDPGPERKLR	B4GALNT2	306	Q8NHY0
LYDVPRERVLPPEVA	BCAR1	386	P56945
LPEPVVARFIRIYPL	AEBP1	511	Q8IUX7
GPKYSPLEFLRRVPL	EFL1	526	Q7Z2Z2
VVKPPYPKIRRASGR	GZF1	211	Q9H116
SFGRVPYPRIPLKDV	CSK	381	P41240
PYPRIPLKDVVPRVE	CSK	386	P41240
LVIRKVQYAPERPGP	ARRB1	166	P49407
EGKYIPLPQRVREGP	ATXN2L	346	Q8WWM7
APANLERPVRYIRKP	ABI2	126	Q9NYB9
EKDVFRLLGLPYREP	POLL	556	Q9UGP5
RREKYGIPEPPEPKR	RBM10	821	P98175
LRPLVYTPELPGRAK	QRFPR	31	Q96P65
PIPYGLIRGRIFFKI	IMMP1L	131	Q96LU5
LLIKRPPFFHYRPGD	NOX5	461	Q96PH1
LRPRRYPQVPDEKDL	LRCH4	526	O75427
IIKVIFRPPEIVPRY	PCDH20	416	Q8N6Y1
LYEPVVIPVGKLFRP	NCF2	171	P19878
PVYGLFRVKVRPGRD	INPP5E	586	Q9NRR6
VDRKERGLPYGIPPD	HHIPL1	361	Q96JK4
PRIVPFRGDYLLLKP	L2HGDH	276	Q9H9P8
EEPTPADGRIIYRKP	KIAA1143	86	Q96AT1
PYPRINLKFGIRKPE	EDEM3	201	Q9BZQ6
EPFVVKLRFEPAGRP	EXD2	391	Q9NVH0
PDIPGFRKILPRSDY	HMGXB3	116	Q12766
SGYEAPRIPPDKRIF	PER1	346	O15534
RIGRPPKYRKIPQED	L3MBTL1	686	Q9Y468
RLYVGGPPLEKEPRE	POLG	361	P54098
LRLKEKSRPPGVPIY	PABPC5	291	Q96DU9
YPLNIGEKPPQVRRR	FRMD4B	466	Q9Y2L6
RFGILTEKYRIPVPI	ETFDH	146	Q16134
YPDPRGRPTKEILEF	DOCK6	521	Q96HP0
KVAPEEAPPRRILIY	SLC1A7	171	O00341
RKEFPYRIPLDLVPK	C5	956	P01031
YRLTLVKRPAEPGGP	ABCA2	1216	Q9BZC7
YPLPDFSKVGPRVRF	AKNA	356	Q7Z591
EPPDRIRPIYSGKFF	EFHB	241	Q8N7U6
PIFDIPGRLYPVREK	DHX40	226	Q8IX18
LRPPRGTPEYVKFAR	ATP4A	91	P20648
LPRPVDPERVPELYK	FGF20	191	Q9NP95
FLRFDPVRGEVPPRY	HPX	206	P02790
RDVAPRIGYPKPALL	WARS1	321	P23381
LIKPYAGPRLPPDRY	TAF9B	106	Q9HBM6
PFLVRVKYLLTPREP	SLC6A6	571	P31641
EADLGRKPPAIPIRY	SLC35B4	51	Q969S0
AVGRYPKPLAELPGR	NKX6-1	186	P78426
PLLGPRRVPVLGKEY	LARS1	1121	Q9P2J5
LEKPRGFFPTPRYLL	OVCH1	851	Q7RTY7
FNGYLPPPVFPVKRR	SHKBP1	126	Q8TBC3
RVPKEPPEIRILNPY	ST3GAL3	261	Q11203
RKIPGYDPEPVEKLR	NOM1	561	Q5C9Z4
RVVYPIRAPLPEDFL	PRDM1	296	O75626
LEGPYPVEEIRLPRA	SCRIB	996	Q14160
EPEGVKIFRCPSPIY	SLC26A3	531	P40879
PYVCKPEERFRAPPI	PRKAB1	191	Q9Y478
EAATLKPPPFLRGRY	CHST5	276	Q9GZS9
KPPPFLRGRYRLVRF	CHST5	281	Q9GZS9
EKILEPRTTRGYKPP	RNF17	1161	Q9BXT8
FKPPLRDLGETRIPY	RNF17	1551	Q9BXT8
GPRVIFIKPYRNRTP	TP53TG5	181	Q9Y2B4
RFEKRIYIPLPEPHA	VPS4B	291	O75351
EGSEIYLPEVVKPPR	TMEM199	81	Q8N511
PLRDPPRRVGIFLDY	TRIM11	396	Q96F44
LPVPPRRVGIFVDYE	TRIM68	416	Q6AZZ1
KRGEPAIYRPLDPKP	STAU2	106	Q9NUL3
ALGPLPYPERQKRAR	SHANK3	876	Q9BYB0
LEPLPIVYYVGRKPK	TGFB1	361	P01137
FKLEVIIPERYPFEP	UBE2T	51	Q9NPD8
IYRIGLKVPPDERDP	UBR1	1301	Q8IWV7
PPGAFSPYKKLRRID	SLIT2	316	O94813
VPRPRRLGVGVYPVK	PITPNM3	701	Q9BZ71
PPDAIPRGKIYEIYL	UNC5A	466	Q6ZN44
ENGFLPDPPRIRYRK	SP140	656	Q13342
PINVKRPVERRFPIY	GTF3C2	741	Q8WUA4
ERVRIPAKYLGYPPP	KDR	346	P35968
VRILPPGEVPLKDIY	VWA8	1426	A3KMH1
RVLVKRKPPRDPLFY	TM6SF1	51	Q9BZW5
RAEARRKPDIPVPYL	TMEM101	41	Q96IK0