Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainTNFR/NGFR_Cys_rich_reg

LAMA5 TNFRSF14

8.15e-0433242IPR001368
DomainC2

PKN1 PLA2G4E

1.33e-02137242SM00239
DomainC2

PKN1 PLA2G4E

1.42e-02142242PS50004
Domain-

PKN1 PLA2G4E

1.54e-021482422.60.40.150
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PKN1 GIGYF1 PHF3 SQSTM1 KIF1C

3.17e-0550326516964243
Pubmed

The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.

SEC31B SQSTM1

6.41e-051626222792322
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

NAT8L XIRP1 GIGYF1 CCDC61 PHF3

1.40e-0468926536543142
Pubmed

FGF signalling regulates bone growth through autophagy.

SEC31B SQSTM1

3.72e-043826226595272
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

LAMA5 PKN1 SQSTM1

5.38e-0421426322199357
CytobandEnsembl 112 genes in cytogenetic band chr7q22

CBLL1 GIGYF1

6.83e-03219262chr7q22
Cytoband19p13.3

APBA3 RAX2

7.95e-0323726219p13.3
CytobandEnsembl 112 genes in cytogenetic band chr19p13

APBA3 PKN1 RAX2

1.01e-02797263chr19p13
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

TMEM119 GIGYF1 CCDC61 TNFRSF14

1.91e-06155264a4f2fffa8d0de760c556c3f8f1c91804eedbfa68
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LAMA5 APBA3 PLA2G4E

7.75e-05143263d0ed8c25da1327085e042c2e03cb7503e2c52ce0
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LAMA5 APBA3 PLA2G4E

7.75e-051432638900b92a24289204b9ec7baccc11594fec7694f1
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-3|TCGA-Colorectal / Sample_Type by Project: Shred V9

APBA3 GPR25 CCDC61

1.00e-04156263b464871ad7c8ce0d58013a27996639eac1e526d8
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

LAMA5 TEAD1 NRG3

1.29e-04170263e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCT TMEM119 XIRP1

1.53e-04180263f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCellCOVID-19-Endothelial_cells-Endothelial_cells_(other)|COVID-19 / group, cell type (main and fine annotations)

LAMA5 NRG3 SYN3

1.56e-0418126326eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D122|Adult / Lineage, Cell type, age group and donor

LAMA5 TEAD1 NRG3

1.63e-04184263561592edc3083fad41b91811151b442207c65dd9
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LAMA5 TEAD1 NRG3

1.63e-04184263d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LAMA5 TEAD1 NRG3

1.63e-0418426357c792e6e2fedba25d3350ffe649fd74750b579d
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1|Children_(3_yrs) / Lineage, Cell type, age group and donor

LAMA5 TEAD1 NRG3

1.66e-041852631c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCellEpithelial-alveolar_epithelial_cell_type_1|World / Lineage, Cell type, age group and donor

LAMA5 TEAD1 NRG3

1.69e-0418626309d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1|Adult / Lineage, Cell type, age group and donor

LAMA5 TEAD1 NRG3

1.71e-0418726377f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCellControl-Endothelial-VE_Capillary_A|Control / Disease state, Lineage and Cell class

LAMA5 NRG3 SYN3

1.71e-0418726354d7588172ac145ff5045ad9771636729ca3f0ca
ToppCellfacs-Tongue-nan-24m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8L PLA2G4E KIF1C

1.74e-04188263ed35e438796cef302b6787c111753425922792dc
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D231|Adult / Lineage, Cell type, age group and donor

LAMA5 TEAD1 NRG3

1.77e-041892635a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCellControl-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

TEAD1 NRG3 SYN3

1.77e-04189263f83f7521e377ded1522639e9a35c98b3e2725bac
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

LAMA5 TEAD1 NRG3

1.79e-0419026330b50d183d7649146eb1e79b47ba897355f1998a
ToppCellControl-Endothelial-VE_Venous|Control / Disease state, Lineage and Cell class

TEAD1 NRG3 SYN3

1.82e-04191263617546cf4883dedf3323e03a53ba5adec334cf8e
ToppCellfacs-Tongue-nan-18m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8L PLA2G4E KIF1C

1.82e-0419126302f24202f9fdd46c648265a5b3b6f9066aa009fc
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-8|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

SCT TMEM119 XIRP1

1.91e-0419426355b97095a7a17a312c616703d291738a0f806339
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA5 TEAD1 NRG3

1.94e-04195263a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCellControl-Endothelial-VE_Arterial|Control / Disease state, Lineage and Cell class

SCT TEAD1 SYN3

1.94e-0419526356c66a3655820961e1390b8f4bcc5618e8d0c5a8
Diseaseautoimmune thyroid disease

GIGYF1 GPR25 TNFRSF14

1.63e-04126253EFO_0006812
DiseaseAge related macular degeneration

RAX2 SQSTM1

2.95e-0430252C0242383
DiseaseAlzheimer's disease biomarker measurement

NRG3 SYN3

7.59e-0448252EFO_0006514
Diseasehypothyroidism

GIGYF1 GPR25 TNFRSF14

1.73e-03284253EFO_0004705
Diseaseneuroblastoma

LAMA5 MAPK1IP1L

4.33e-03116252EFO_0000621
DiseaseSclerocystic Ovaries

SCT SPATA21

6.59e-03144252C1136382
DiseasePolycystic Ovary Syndrome

SCT SPATA21

6.59e-03144252C0032460
Diseaseanthropometric measurement

TEAD1 SYN3

8.87e-03168252EFO_0004302
Diseaseautoimmune disease

GIGYF1 TNFRSF14

9.38e-03173252EFO_0005140
Diseaseblood phosphate measurement

TMEM119 SYN3

9.49e-03174252EFO_0010972
Diseasecolorectal health

XIRP1 TEAD1

1.25e-02201252EFO_0008460

Protein segments in the cluster

PeptideGeneStartEntry
PSPTPWSGSNMKSPP

CCDC61

446

Q9Y6R9
MAPTEPWSPSPGSAP

GPR25

1

O00155
LTPDSQWDPMPGGPG

APBA3

31

O96018
PPAMSLPLEPWLGPG

RAX2

111

Q96IS3
PVPGTPSTQAMPSWP

NRG3

211

P56975
PGPGNPSPMSLSPAW

ESPNL

361

Q6ZVH7
KMWGRVPFAPGPSPP

GIGYF1

526

O75420
WPGMGSGEAPTPLQP

KIF1C

991

O43896
GGLPEPMAVQPWPPA

LAMA5

3646

O15230
PPFTQPGGMSPGIWP

CBLL1

441

Q75N03
TPGLPPFCPMAPWGS

PLA2G4E

46

Q3MJ16
PLDGTWSPWLPPGPM

SCT

91

P09683
WSPWLPPGPMVSEPA

SCT

96

P09683
PLGPWGSMSSGPWAP

MAPK1IP1L

141

Q8NDC0
LPMPGGTAPSPLRPW

SYN3

396

O14994
LSPMGPPLPWPVGST

STK11IP

336

Q8N1F8
WARLPAPGPEPAPMG

SPATA21

141

Q7Z572
PWNPTPSMGGPGTPD

PKN1

341

Q16512
GTWPLPGSPLPMACP

SEC31B

906

Q9NQW1
PGWEMGPPGNWSPRP

SQSTM1

196

Q13501
VPGPLSPWAQGMQPP

TEX13D

206

A0A0J9YY54
PPPGFGFAQNPMVPW

PHF3

1841

Q92576
MEPPGDWGPPPWRST

TNFRSF14

1

Q92956
PRPTFPGAPGFWPGM

TEAD1

146

P28347
PPWTPALSPTSMGPQ

TMEM119

56

Q4V9L6
TSPQWGPGPSGEQPM

XIRP1

1436

Q702N8
GAMWPPLPAAPGPAA

NAT8L

36

Q8N9F0