Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondisordered domain specific binding

NCOA3 TP53

8.38e-0439222GO:0097718
GeneOntologyMolecularFunctionprotease binding

LRP1 TP53 FN1

9.94e-04181223GO:0002020
GeneOntologyMolecularFunctionproteoglycan binding

LRP1 FN1

1.43e-0351222GO:0043394
GeneOntologyMolecularFunctionligase activity, forming carbon-nitrogen bonds

GCLC RIMKLB

1.54e-0353222GO:0016879
GeneOntologyMolecularFunctionbasal RNA polymerase II transcription machinery binding

NCOA3 TP53

2.38e-0366222GO:0001099
GeneOntologyMolecularFunctionbasal transcription machinery binding

NCOA3 TP53

2.38e-0366222GO:0001098
GeneOntologyMolecularFunctioncopper ion binding

F8 TP53

3.31e-0378222GO:0005507
GeneOntologyBiologicalProcessmitochondrial DNA repair

NEURL4 TP53

3.03e-058222GO:0043504
GeneOntologyBiologicalProcessmitochondrial transport

GCLC SLC25A18 TP53 ROMO1

6.02e-05205224GO:0006839
Pubmed

Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE.

LRP1 F8

3.82e-07222227794518
Pubmed

A common polymorphism decreases LRP1 mRNA stability and is associated with increased plasma factor VIII levels.

LRP1 F8

3.82e-07222228431990
Pubmed

Proteolytic cleavage of factor VIII heavy chain is required to expose the binding-site for low-density lipoprotein receptor-related protein within the A2 domain.

LRP1 F8

3.82e-07222216839343
Pubmed

Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.

LRP1 F8

3.82e-07222225903134
Pubmed

Upregulation of fibronectin following loss of p53 function is a poor prognostic factor in ovarian carcinoma with a unique immunophenotype.

TP53 FN1

3.82e-07222232635925
Pubmed

Diagnostic value of fibronectin and mutant p53 in the urine of patients with bladder cancer: impact on clinicopathological features and disease recurrence.

TP53 FN1

3.82e-07222220012564
Pubmed

Wild-type p53 controls the level of fibronectin expression in breast cancer cells.

TP53 FN1

3.82e-07222228765903
Pubmed

Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation.

LRP1 F8

3.82e-07222218166789
Pubmed

Cluster III of low-density lipoprotein receptor-related protein 1 binds activated blood coagulation factor VIII.

LRP1 F8

3.82e-07222225486042
Pubmed

The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces.

LRP1 FN1

3.82e-07222211867643
Pubmed

LRP1 is required for novobiocin-mediated fibronectin turnover.

LRP1 FN1

3.82e-07222230061663
Pubmed

Macrophage LRP1 contributes to the clearance of von Willebrand factor.

LRP1 F8

1.15e-06322222234691
Pubmed

A test of the role of alpha5 integrin/fibronectin interactions in tumorigenesis.

TP53 FN1

1.15e-0632229485045
Pubmed

Low density lipoprotein receptor-related protein and factor IXa share structural requirements for binding to the A3 domain of coagulation factor VIII.

LRP1 F8

1.15e-06322212522143
Pubmed

NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization.

NEURL4 TP53

1.15e-06322228977907
Pubmed

The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells.

TP53 FN1

1.15e-06322211751853
Pubmed

The binding sites for the very low density lipoprotein receptor and low-density lipoprotein receptor-related protein are shared within coagulation factor VIII.

LRP1 F8

1.15e-06322218277139
Pubmed

[Research of fibronectin, p53 and Ezrin protein with occurrence, progress and prognosis in the primary laryngeal carcinoma by the tissuechip technology].

TP53 FN1

1.15e-06322215835821
Pubmed

Contribution of low density lipoprotein receptor-related protein genotypes to coagulation factor VIII levels in thrombotic women.

LRP1 F8

1.15e-06322216956829
Pubmed

Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53.

NCOA3 TP53

2.29e-06422210551785
Pubmed

Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation.

NPC1 TP53

2.29e-06422220386595
Pubmed

SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization.

NCOA3 TP53

2.29e-06422223388826
Pubmed

Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase.

TP53 FN1

2.29e-06422215331608
Pubmed

Regulation of the MDM2-p53 pathway by the ubiquitin ligase HERC2.

NEURL4 TP53

2.29e-06422231665549
Pubmed

Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.

LRP1 F8

3.82e-06522218685438
Pubmed

Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development.

TP53 FN1

3.82e-06522222821713
Pubmed

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.

F8 TP53

8.01e-06722226456157
Pubmed

Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.

NCOA3 TP53

1.07e-05822210490106
Pubmed

TAp63 prevents premature aging by promoting adult stem cell maintenance.

TP53 FN1

1.71e-051022219570515
Pubmed

Jun and JunD-dependent functions in cell proliferation and stress response.

GCLC TP53

5.16e-051722220300111
Pubmed

Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.

TP53 FN1

5.81e-051822211311202
Pubmed

Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation.

TP53 FN1

1.05e-042422226744331
Pubmed

Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation.

FASTKD5 TP53

1.43e-042822232376682
Pubmed

The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.

TP53 FN1

1.53e-042922219094228
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

PSMB8 NPC1 NCOA3 ROMO1

1.78e-0445722432344865
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PREX1 NEURL4 DENND3 RIMKLB

2.38e-0449322415368895
Pubmed

mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia.

PSMB8 TP53

2.94e-044022234677125
Pubmed

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.

TP53 FN1

2.94e-044022229180744
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

NPC1 LRP1 FN1

3.24e-0421422322199357
Pubmed

Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.

LRP1 FN1

3.56e-044422231273033
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

NPC1 GCLC FN1

3.81e-0422622337839992
Pubmed

mTORC1 accelerates retinal development via the immunoproteasome.

PSMB8 TP53

3.89e-044622229950673
Pubmed

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

NPC1 LRP1

4.06e-044722211208732
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

LRP1 F8 FN1

5.54e-0425722316335952
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

LRP1 FASTKD5 MBTD1 TP53 RTL9

5.63e-04111622531753913
GeneFamilyWD repeat domain containing

ARPC1B DENND3

1.25e-02262122362
ToppCellMacrophages-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

LRP1 MS4A4A ARPC1B FN1

2.12e-061902248c49622a43422c07659f74edffe1ceab87621381
ToppCellMacrophages-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

LRP1 MS4A4A ARPC1B FN1

2.26e-06193224642f8f20e5a35a4b5d1fc8d3f1e3b9b83a37a654
ToppCellCV-Severe-6|CV / Virus stimulation, Condition and Cluster

NCOA3 PREX1 DENND3 ROMO1

2.35e-0619522469095c6ce2a7e763afa543c10d5710e0c3dda769
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 MS4A4A ARPC1B FN1

2.35e-061952249e49e59a20b1bbd6167d594c33ab6bdfe2c1ebaf
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 MS4A4A ARPC1B FN1

2.35e-06195224412a9fcf9f075d97fae254bbd89774e4b1face07
ToppCellASK440-Immune-Macrophages|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

LRP1 MS4A4A ARPC1B FN1

2.45e-0619722469d88b15abdc6ec5d3b6c66e88e9a7046eb3eac9
ToppCelldistal-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LRP1 MS4A4A ROMO1 FN1

2.50e-061982246aef5f5f89b508b214e1ab1876a743dedda0553b
ToppCellASK428-Immune-Macrophages|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

LRP1 MS4A4A ARPC1B FN1

2.50e-061982241d9bd6e13e54308687e56a6b4f3d4e9d411b1cb2
ToppCellASK440-Immune|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

LRP1 MS4A4A ARPC1B FN1

2.50e-061982246a63a2988d848c2b81202d3def02ad16f29c42d6
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 MS4A4A ARPC1B FN1

2.55e-0619922494308fa48d73bedbfaf0e68570e151af26563b01
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|343B / Donor, Lineage, Cell class and subclass (all cells)

LRP1 MS4A4A FN1

6.96e-05164223057ca87847373eff7fe97dd9f4358509e66ca4c3
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSMB8 ARPC1B SLC25A18

7.48e-051682231fabb2455ce15315f19f01ea9308bc9e453cc095
ToppCellfacs-Marrow-B-cells-18m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 ROMO1 FN1

7.74e-051702236e82e41acd1299aa549a32ac036b39754abdf376
ToppCellfacs-Marrow-B-cells-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 ROMO1 FN1

7.74e-0517022318cd941bf3ca7cc0b6af1317bd2619d283353de0
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PSMB8 ARPC1B ACOXL

8.01e-05172223adf016e5856bc85e7bed58aee09ade483b9dcb00
ToppCellE18.5-samps-Epithelial-Alveolar_epithelial-AT2|E18.5-samps / Age Group, Lineage, Cell class and subclass

NPC1 GCLC ACOXL

8.15e-05173223f6e36ea98a9c669ff393d141455aaecef083f738
ToppCellMacrophages-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

MS4A4A ARPC1B FN1

8.15e-05173223a112da5b0ab6e1f13d1a7dfa72c67c9a95fa9243
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic-Neutrophil|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 PREX1 DENND3

8.58e-05176223676839d07450b313222622e0ffd305c732cbad6d
ToppCell3'_v3-GI_small-bowel-Myeloid_Mac-Macrophage|GI_small-bowel / Manually curated celltypes from each tissue

LRP1 MS4A4A FN1

8.58e-051762234be270f6bb7da4070f972aca403109751646d155
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PREX1 F8 FN1

9.02e-051792238f9e538c822940785130297712b75131812a4603
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MS4A4A ARPC1B FN1

9.02e-05179223b07ebfd4157ae7436f275add78f2ac9ffc55f417
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PREX1 ARPC1B DENND3

9.17e-051802235861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PREX1 ARPC1B DENND3

9.17e-0518022397e0dcb7cfbba60a782824c5e23995058609fcd4
ToppCell10x5'-bone_marrow-Myeloid_Mac-Macrophage|bone_marrow / Manually curated celltypes from each tissue

MS4A4A RIMKLB FN1

9.32e-05181223d2aa5b53162fb5c4cbbedbd2cb4b2b614e8c4afa
ToppCelldroplet-Lung-30m-Hematologic-myeloid|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP1 ARPC1B FN1

9.32e-0518122375751d390812c98cc2b32ab578cdb15b34a80750
ToppCellcellseq2-Immune-Immune_Myeloid-AM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MS4A4A ARPC1B FN1

9.32e-05181223d4ab8ab41bf3e6f1937e919662456d7c9551eeab
ToppCellcellseq2-Immune-Immune_Myeloid-AM-AM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MS4A4A ARPC1B FN1

9.32e-0518122345fc9c27ea60312a118a2a6c1eb635d776fde295
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-1|TCGA-Lung / Sample_Type by Project: Shred V9

PSMB8 ARPC1B ROMO1

9.32e-0518122378b646feca39d1bfd68f9843b7f557b3fac56829
ToppCell3'_v3-lymph-node_spleen-Myeloid_Mac-Macrophage|lymph-node_spleen / Manually curated celltypes from each tissue

LRP1 MS4A4A FN1

9.63e-051832230bcbd60e10b9d6898915dab1987fd46dc7238b19
ToppCellPND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 GCLC ACOXL

9.94e-05185223fd51fef8c69e34c72017d8371ab0a0d7be5701f2
ToppCellPND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 GCLC ACOXL

9.94e-05185223bea26e369ae91006052b973cd89b4c49afa9e553
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP1 MS4A4A FN1

9.94e-051852237bff05d8d34616adbaa0ea0b69eb30aa906bb9f8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MS4A4A ARPC1B DENND3

9.94e-0518522376fc5bbb71e42c0eb70474efcd3a71a7b2633f24
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell|TCGA-Uvea / Sample_Type by Project: Shred V9

ARPC1B DENND3 FN1

1.01e-04186223e8580a2093eb7e50aad55ec7fada850d2fed8ae1
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 GCLC ACOXL

1.03e-041872236ab51e17a7782c2ae6394cad813dc3a2cde70c89
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.0.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MS4A4A ARPC1B FN1

1.03e-04187223cbe25fb3fc8ed6245dc767c884c298c89a774cce
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 MS4A4A FN1

1.03e-041872237b24a324335c30c4b37795c43611b297274c804b
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 GCLC ACOXL

1.03e-04187223e176b5b051690f840f3b12c8f7c4cc10cbe2bbae
ToppCell10x5'-GI_large-bowel-Myeloid_Monocytic|GI_large-bowel / Manually curated celltypes from each tissue

LRP1 MS4A4A FN1

1.04e-04188223d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes|GI_large-bowel / Manually curated celltypes from each tissue

LRP1 MS4A4A FN1

1.04e-041882230bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 GCLC ACOXL

1.04e-04188223562f5984efdbbcb8f53ddcee033ccbf9eb678425
ToppCellMacrophages-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

LRP1 MS4A4A FN1

1.06e-04189223c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 MS4A4A FN1

1.06e-04189223a59025e82fabd9d60e2438dee85b2644478cc7c8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PREX1 F8 FN1

1.08e-04190223bf9bc57a605c7e3979bc4f7260e6fb92c3eb8690
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 GCLC ACOXL

1.08e-041902238ff8c586237cf15f930416710bcff45205fe6f70
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_2|356C / Donor, Lineage, Cell class and subclass (all cells)

LRP1 MS4A4A FN1

1.08e-041902234cce4ddb79b7751d0103e10f71156977e0c34439
ToppCellCOPD-Myeloid-Macrophage_Alveolar|COPD / Disease state, Lineage and Cell class

LRP1 MS4A4A FN1

1.08e-04190223006e31606d637033bc81333816ee332773d36b08
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_2|343B / Donor, Lineage, Cell class and subclass (all cells)

LRP1 MS4A4A FN1

1.08e-041902236514f00d222eef08c282face7f177259bca62f0e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MS4A4A PREX1

1.08e-04190223788ff9d8888d2dd25b7e1d7e0e5d57751ce86f19
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP1 MS4A4A FN1

1.09e-041912235c0c44612b4cdbf89c0f1f219416374a7541f610
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 GCLC ACOXL

1.09e-0419122308b1d3b3be78bf7fd9e9039027e35275f2be88d0
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MS4A4A ARPC1B FN1

1.09e-04191223723dc09607e791e9517a22c6482d6cd6b07ce1d6
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 GCLC ACOXL

1.09e-04191223f896fb490c4a17adac5e00ed9b6e6145eab1e564
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 GCLC ACOXL

1.09e-041912232f71f1fb6b5872d84860840b22e789a87ab14eec
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 GCLC ACOXL

1.09e-041912234ab3056f9af2a6caed39f32288562f480811cd7b
ToppCellPND14-Epithelial-Epithelial_Alveolar|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPC1 GCLC ACOXL

1.09e-041912235f8b3b2d38b37027901db9a1cccdbd1ff70f29de
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PREX1 F8 FN1

1.11e-04192223c0e59e642b42c055cf73d029cf54d07d9b719359
ToppCellChildren_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

LRP1 MS4A4A ARPC1B

1.13e-041932238b2f89c3cf137315eed05d9edb5fc6011c5325a8
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_4|343B / Donor, Lineage, Cell class and subclass (all cells)

LRP1 MS4A4A FN1

1.13e-04193223b9dcffd28ca309359fb110fb79de8ce066208ee1
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)|Adult / Lineage, Cell type, age group and donor

LRP1 MS4A4A PREX1

1.13e-0419322331c0978ba78c9516d498aec0798902e57555e557
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PREX1 F8 FN1

1.13e-0419322352e918884877b6659cdca0496390e440f73694a9
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MS4A4A ARPC1B FN1

1.14e-04194223412c2b8eb522da6c84f8b00d32d6f0bee555251f
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

GCLC MS4A4A PREX1

1.14e-04194223663e7e7fe48157e808b4f1a0ea6ad41944e857a2
ToppCellCOVID-19_Convalescent-PLT_4|COVID-19_Convalescent / Disease Group and Platelet Clusters

PSMB8 NCOA3 MBTD1

1.14e-04194223ce1fad4e76a87f0c35e430ed1f2262395df882fd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MS4A4A PREX1

1.14e-041942231dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCellMacrophages|World / lung cells shred on cell class, cell subclass, sample id

LRP1 MS4A4A FN1

1.14e-04194223baf7ae36826f04acb2b2975f80cd1287daec4261
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MS4A4A PREX1

1.14e-0419422345708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PREX1 F8 FN1

1.14e-0419422374a9fdb73f279bebb6337510deab9aaaf9f7e957
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NPC1 MS4A4A ARPC1B

1.14e-04194223fa50c77a6d6b083cdafdb07243bc68b894977487
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PREX1 F8 FN1

1.14e-04194223e55dc30e200c9f576804acb642175eb4fa9146b5
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-memory_B_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GCLC NCOA3 DENND3

1.14e-04194223f0c113edb706d53792892115b67277a285219942
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NPC1 MS4A4A ARPC1B

1.16e-04195223ef2304acb01638df197f42dcc3db8c5867f4dc17
ToppCell3'-Distal_airway-Immune_Myeloid|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 MS4A4A ARPC1B

1.16e-041952234df004b8ca7669a57d85c6dffef5b82b4ea1dfdf
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MS4A4A PREX1

1.16e-04195223247803cf58c6d9c561a52aa34e581188ddad197e
ToppCell343B-Myeloid-Macrophage|343B / Donor, Lineage, Cell class and subclass (all cells)

LRP1 MS4A4A FN1

1.16e-0419522348ba2044d2459c8b0d17bc7deca8d0195ac6a00e
ToppCellCOVID-19-kidney-PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

F8 DENND3 FN1

1.16e-04195223a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MS4A4A PREX1

1.16e-0419522342bfdff88da1d07828c0ad65d412fb1752f0cee4
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NPC1 MS4A4A ARPC1B

1.16e-041952235ed495941b80221206b8a9a86d92221ab8ba6682
ToppCellBronchial_Biopsy-Immune-Luminal_Macrophages|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

LRP1 MS4A4A FN1

1.16e-041952236800c17026ec6c56132bf4664b8fcd74d7836579
ToppCellMacrophages-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

LRP1 MS4A4A PREX1

1.16e-04195223eb104f3bb08ab9eca31273c0523a5c90de1f30a9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MS4A4A PREX1

1.16e-0419522309df40ff9b493170861b3f6e57a942a834655b5c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MS4A4A PREX1

1.16e-0419522334a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PREX1 F8 FN1

1.18e-04196223023312af38f816a44b407e0daa32590d953caf99
ToppCell3'_v3-Lung|World / Manually curated celltypes from each tissue

LRP1 MS4A4A FN1

1.18e-04196223a04f8384b734ce67ec402e64bd891a6274f04744
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LRP1 MS4A4A FN1

1.18e-041962235ed7f063fc4ba213fe15256caf77f59c9e476290
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PREX1 F8 FN1

1.18e-04196223adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MS4A4A ARPC1B FN1

1.18e-041962232793ad692d49b3ee78a5cd2d8e0220bf5188a686
ToppCellfacs-Brain_Non-Myeloid-Cortex|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPC1 PREX1 SLC25A18

1.18e-04196223256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP1 MS4A4A FN1

1.18e-041962237ce416e1809bfbb39553c28c20125790100a938d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PREX1 F8 FN1

1.18e-0419622322767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRP1 MS4A4A FN1

1.18e-04196223292da8a0c052917a2f68afee9068b5b8e1544b13
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MS4A4A ARPC1B FN1

1.18e-04196223aae79eafe5bc2c7de16958994a2fe97439d7bea1
ToppCellnormal_Lung-Myeloid_cells|normal_Lung / Location, Cell class and cell subclass

MS4A4A ARPC1B FN1

1.20e-041972236407aa446a87a9c6fca723718acc19fd3afe06e8
ToppCell343B-Myeloid-Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LRP1 MS4A4A FN1

1.20e-041972231b6f7a62b7fcfd55c25c5840353eed7183050860
ToppCellSmart-seq2-thymus_(Smart-seq2)-myeloid-myeloid_macrophage-macrophage|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP1 GCLC MS4A4A

1.20e-04197223e567886d69c6ea8dec87019c2ebc593793cb3107
ToppCellnormal_Lung-Myeloid_cells-Alveolar_Mac|normal_Lung / Location, Cell class and cell subclass

MS4A4A ARPC1B FN1

1.20e-04197223a158d8e697a122aa282f25a580179419644e749f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MS4A4A PREX1

1.20e-041972238af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MS4A4A ARPC1B DENND3

1.20e-04197223769a4203c014b34d16d4d76d3caf07ddb2c41abc
ToppCellMNPs-Macrophages|MNPs / lung cells shred on cell class, cell subclass, sample id

LRP1 MS4A4A FN1

1.20e-0419722303d74643646dce5d3a278a1ee48c390d13a7889c
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

MS4A4A ARPC1B FN1

1.20e-041972231ded28732ea5d1f9ebca0b136575103540600ff1
DrugPolycyclic Aromatic Hydrocarbons

GCLC ARPC1B TP53 FN1

6.45e-06128224ctd:D011084
DrugS-ethyl glutathione

GCLC TP53 FN1

6.46e-0638223ctd:C042431
Drugdn B

PSMB8 GCLC NCOA3

7.56e-0640223CID000008331
Drugtetrahydrofurfuryl methacrylate

F8 FN1

8.90e-065222CID000017151
DrugNPCB

NPC1 TP53

8.90e-065222CID000146853
DrugEthacrynic Acid

GCLC TP53 FN1

1.08e-0545223ctd:D004976
Drugkaempferol

GCLC NCOA3 TP53 FN1

1.18e-05149224ctd:C006552
DrugCoagulation Factor IX

LRP1 F8

1.87e-057222DB00100
Drug2-nitrofluorene

PSMB8 GCLC ARPC1B FN1

2.07e-05172224ctd:C019499
DrugAC1NRAX5

TP53 FN1

3.20e-059222CID005288137
Drugethyl acrylate

GCLC TP53

3.20e-059222ctd:C040833
DrugPropofol [2078-54-8]; Down 200; 22.4uM; MCF7; HT_HG-U133A

F8 MBTD1 POMT1 FN1

3.59e-051982245306_DN
Drugtris(2,3-dibromopropyl)isocyanurate

NCOA3 TP53

3.99e-0510222ctd:C541743
DrugMG 262

TP53 FN1

3.99e-0510222ctd:C423917
Drugcalcium oxalate monohydrate

GCLC TP53 FN1

4.29e-0571223CID000122156
Druglinalool

GCLC TP53 FN1

4.47e-0572223ctd:C018584
Drugcresidine

GCLC TP53

4.88e-0511222ctd:C013453
Drugnotoginsenoside R1

GCLC TP53 FN1

6.60e-0582223ctd:C072936
Drugdibenzyl-N,N-diethylphosphoramidite

GCLC TP53 FN1

8.43e-0589223CID005066231
DrugHoechst 33258

NPC1 TP53 FN1

9.91e-0594223CID005326397
Drugbenzidine

GCLC TP53

1.06e-0416222ctd:C029876
Drugethyl methacrylate

F8 FN1

1.06e-0416222CID000007343
Drug2-acetylaminofluorene

GCLC F8 TP53 FN1

1.06e-04262224CID000005897
DrugAsbestos, Crocidolite

OR10K1 NPC1 GCLC NCOA3 FASTKD5 TP53 FN1

1.16e-041241227ctd:D017638
Drugdiethyl sulfate

GCLC TP53

1.20e-0417222ctd:C011612
Drug2-chloro-5-nitrobenzanilide

GCLC TP53 FN1

1.26e-04102223ctd:C457499
DrugAC1L9N61

GCLC SLC25A18 TP53

1.26e-04102223CID000449471
Drugschizandrin B

GCLC TP53

1.35e-0418222ctd:C015499
DrugBiomer

F8 FN1

1.35e-0418222CID003085227
DrugDactinomycin

GCLC TP53 POMT1 FN1

1.57e-04290224ctd:D003609
Drug4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

NPC1 GCLC TP53 FN1

1.59e-04291224ctd:C016583
Drugchrysin

GCLC TP53 FN1

1.80e-04115223ctd:C043561
Drugerdosteine

GCLC TP53

1.85e-0421222ctd:C048498
DrugButhionine Sulfoximine

NPC1 GCLC TP53 FN1

1.93e-04306224ctd:D019328
DrugPVLA

NPC1 FN1

2.03e-0422222CID000126094
Drugmethylmercury hydroxide

GCLC TP53

2.03e-0422222ctd:C020771
Drugfipronil

NPC1 LRP1 GCLC F8 TP53

2.22e-04597225ctd:C082360
DrugNimustine

GCLC TP53

2.23e-0423222ctd:D015376
Drugangiogenesis inhibitor

GCLC TP53 FN1

2.47e-04128223CID002812173
Drugcyanoginosin LR

LRP1 GCLC TP53 FN1

2.52e-04328224ctd:C057862
DrugGestodene

F8 FN1

2.86e-0426222ctd:C033273
DrugGlutathione

LRP1 GCLC TP53 FN1

2.89e-04340224ctd:D005978
DrugNSC3056

GCLC TP53 FN1

3.02e-04137223CID000001599
Drugethidium homodimer

GCLC FN1

3.08e-0427222CID004072365
DrugDiamide

GCLC TP53

3.32e-0428222ctd:D003958
DrugThiabendazole

GCLC TP53

3.56e-0429222ctd:D013827
Drug3-hydroxyflavone

NCOA3 FN1

3.56e-0429222ctd:C041477
Drugfullerene C60

PSMB8 LRP1 NCOA3 PREX1 DENND3 TP53 ROMO1

3.73e-041498227ctd:C069837
DrugAC1L1BEB

NPC1 TP53

3.81e-0430222CID000001402
DrugAC1L1WED

F8 FN1

4.07e-0431222CID000062061
DrugStaurosporine

GCLC TP53 FN1

4.17e-04153223ctd:D019311
DrugAC1O7G0A

GCLC FN1

4.34e-0432222CID000002308
DrugLinoleic Acids, Conjugated

GCLC TP53

4.62e-0433222ctd:D044243
DrugSB 203580

LRP1 GCLC TP53 FN1

4.76e-04388224ctd:C093642
Drugprobucol

NPC1 LRP1 TP53

4.93e-04162223CID000004912
Drugalpha-Tocopherol

GCLC TP53 FN1

5.11e-04164223ctd:D024502
Drugpyrrolidone

GCLC F8

5.20e-0435222CID000012025
DrugAG957

TP53 FN1

5.20e-0435222CID000002064
Drugkhellin

NCOA3 ARPC1B FN1

5.77e-04171223CID000003828
DrugGinkgo biloba extract

GCLC TP53

5.82e-0437222ctd:C063170
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

NPC1 DENND3 FN1

6.38e-041772233462_UP
DrugExcitatory Amino Acid Agents

GCLC TP53

6.46e-0439222ctd:D018683
DrugDesoxycorticosterone Acetate

GCLC TP53

6.46e-0439222ctd:D064791
Drugvanillin

GCLC TP53

6.46e-0439222ctd:C100058
Druglomustine; Up 200; 100uM; PC3; HT_HG-U133A

NPC1 GCLC NCOA3

6.49e-041782237094_UP
Drugselenide ion

GCLC TP53 FN1

6.49e-04178223CID000107674
DrugTrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

NPC1 DENND3 FN1

6.59e-041792236951_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

NPC1 DENND3 FN1

6.59e-041792236551_UP
DrugSAHA; Up 200; 10uM; MCF7; HT_HG-U133A

NPC1 DENND3 FN1

6.70e-041802236939_UP
Drug10-hydroxycamptothecin

GCLC TP53

6.80e-0440222CID000097226
DrugSodium Cholate

GCLC TP53

6.80e-0440222ctd:D020358
DrugSecurinine [5610-40-2]; Up 200; 18.4uM; PC3; HT_HG-U133A

NPC1 GCLC NCOA3

6.81e-041812234493_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

NPC1 DENND3 FN1

6.92e-041822237043_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

NPC1 DENND3 FN1

6.92e-041822236879_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

NPC1 DENND3 FN1

7.03e-041832236910_UP
Drugscriptaid; Up 200; 10uM; MCF7; HT_HG-U133A

NPC1 DENND3 FN1

7.14e-041842236901_UP
Drugscriptaid; Up 200; 10uM; PC3; HT_HG-U133A

NPC1 NCOA3 DENND3

7.14e-041842236919_UP
Drugesculetin

TP53 FN1

7.14e-0441222ctd:C007628
DrugGoserelin

NPC1 TP53

7.14e-0441222CID000047725
Drugprochlorperazine dimaleate salt; Up 200; 10uM; PC3; HT_HG-U133A

NPC1 MBTD1 DENND3

7.25e-041852231215_UP
Drugapocynin

GCLC TP53 FN1

7.37e-04186223CID000002214
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

NPC1 DENND3 FN1

7.37e-041862236891_UP
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

NPC1 DENND3 FN1

7.37e-041862237499_UP
DrugMethotrimeprazine maleat salt [7104-38-3]; Up 200; 9uM; PC3; HT_HG-U133A

NCOA3 DENND3 FN1

7.60e-041882233701_UP
DrugPromazine hydrochloride [53-60-1]; Up 200; 12.4uM; PC3; HT_HG-U133A

LRP1 NCOA3 DENND3

7.72e-041892234308_UP
Drugtrichostatin A; Up 200; 0.1uM; MCF7; HG-U133A

NPC1 DENND3 POMT1

7.84e-04190223331_UP
Drugtert-butylthio

NCOA3 FN1

7.86e-0443222CID000006387
DrugNorcyclobenzaprine [303-50-4]; Up 200; 15.4uM; PC3; HT_HG-U133A

LRP1 MS4A4A DENND3

7.96e-041912234190_UP
DrugThioridazine hydrochloride [130-61-0]; Up 200; 9.8uM; HL60; HG-U133A

NCOA3 MBTD1 FN1

7.96e-041912231986_UP
DrugDeptropine citrate [2169-75-7]; Up 200; 7.6uM; PC3; HT_HG-U133A

LRP1 DENND3 ACOXL

8.08e-041922235118_UP
DrugRapamycin; Up 200; 0.1uM; PC3; HT_HG-U133A

LRP1 DENND3 FN1

8.20e-041932234466_UP
DrugPyrithyldione [77-04-3]; Down 200; 24uM; PC3; HT_HG-U133A

F8 MBTD1 FN1

8.20e-041932237153_DN
Drug2-methylbutylamine

F8 FN1

8.23e-0444222CID000007283
DrugBeta-Escin [11072-93-8]; Down 200; 3.2uM; PC3; HT_HG-U133A

LRP1 DENND3 FN1

8.32e-041942233807_DN
DrugAlthiazide [5588-16-9]; Down 200; 10.4uM; HL60; HT_HG-U133A

NCOA3 F8 MBTD1

8.32e-041942232527_DN
Drug(-)-Isoproterenol hydrochloride [5984-95-2]; Down 200; 16.2uM; PC3; HT_HG-U133A

LRP1 DENND3 FN1

8.45e-041952234495_DN
DrugCarisoprodol [78-44-4]; Down 200; 15.4uM; PC3; HT_HG-U133A

LRP1 MBTD1 DENND3

8.58e-041962236610_DN
DrugTrimethoprim [738-70-5]; Down 200; 13.8uM; PC3; HT_HG-U133A

F8 DENND3 POMT1

8.58e-041962237377_DN
Drug4-dideoxy-1,4-imino-D-xylitol

TP53 ROMO1 FN1

8.58e-04196223CID000001335
DrugMinaprine dihydrochloride [25953-17-7]; Up 200; 10.8uM; HL60; HG-U133A

F8 POMT1 FN1

8.58e-041962231968_UP
Diseasemonocyte percentage of leukocytes

NPC1 GCLC MS4A4A NEURL4 TP53 ACOXL

1.20e-05731226EFO_0007989
Diseasepulse pressure measurement, migraine without aura, susceptibility to, 4

LRP1 TP53

1.90e-059222EFO_0005763, MONDO_0011847
DiseaseNeoplastic Cell Transformation

GCLC TP53 FN1

1.48e-04139223C0007621
Diseasebreast cancer (implicated_via_orthology)

NCOA3 TP53

1.58e-0425222DOID:1612 (implicated_via_orthology)
DiseaseNon-Small Cell Lung Carcinoma

GCLC NCOA3 TP53

2.07e-04156223C0007131
Diseasemyelodysplastic syndrome (is_implicated_in)

ARPC1B TP53

2.28e-0430222DOID:0050908 (is_implicated_in)
Diseaselymphoid leukemia

TP53 ACOXL

3.67e-0438222EFO_0004289
DiseaseHypertensive disease

GCLC TP53 FN1

3.70e-04190223C0020538
Diseaseureteral obstruction (biomarker_via_orthology)

ROMO1 FN1

5.15e-0445222DOID:5199 (biomarker_via_orthology)
DiseaseChronic Lymphocytic Leukemia

TP53 ACOXL

7.69e-0455222C0023434
Diseasepolyp of colon

PREX1 TP53

7.98e-0456222MONDO_0021400
DiseaseIGA glomerulonephritis

PSMB8 ACOXL

8.55e-0458222EFO_0004194

Protein segments in the cluster

PeptideGeneStartEntry
KCSQFCTTGMDGGMS

ARPC1B

341

O15143
CCTGNSIMVMKMNGS

DENND3

1046

A2RUS2
CRECTGGMGYMMENR

ACOXL

346

Q9NUZ1
SNMMCQYRGMGLSMG

PSMB8

156

P28062
DGKSGMATCEMCGMV

MBTD1

46

Q05BQ5
CSNGGSCTMNSKMMP

LRP1

4381

Q07954
IYMDAMGFGMGNCCL

GCLC

236

P48506
MGCDLNSCSMPLGME

F8

2186

P00451
YMCNSSCMGGMNRRP

TP53

236

P04637
SSKGQNMVCGGMGCN

NPC1

901

O15118
NMVCGGMGCNNDSLV

NPC1

906

O15118
CMRPACMGQMQMSQG

POMT1

241

Q9Y6A1
CMGQMQMSQGVCVFC

POMT1

246

Q9Y6A1
SGAMEMAGLCPAACM

FASTKD5

676

Q7L8L6
NGQMMSCTCLGNGKG

FN1

2361

P02751
NLKMEMLAGCGAGMC

SLC25A18

101

Q9H1K4
GITMMCMASNTYGSN

MS4A4A

81

Q96JQ5
MTNLQSGTIMMSGCG

NEURL4

396

Q96JN8
MGHGVCMGLMAAACA

OR10K1

136

Q8NGX5
RATASGCGMGMSMPQ

RTL9

1046

Q8NET4
MGFVMGCAVGMAAGA

ROMO1

21

P60602
MAGCNSSVGGMSMSP

NCOA3

391

Q9Y6Q9
GACQMVMCGTGMQRS

PREX1

1576

Q8TCU6
MQSNCSLGGVGMMCS

RIMKLB

226

Q9ULI2