Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	WW domain binding	NDFIP2 NDFIP1	2.02e-04	25	17	2	GO:0050699
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC44A2 SLC24A1 ABCA13 SLC28A3	5.98e-04	477	17	4	GO:0022804
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC44A2 SLC24A1 SLC28A3	1.88e-03	296	17	3	GO:0015291
GeneOntologyMolecularFunction	deubiquitinase activity	PRPF8 USP34	4.89e-03	124	17	2	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	PRPF8 USP34	5.94e-03	137	17	2	GO:0019783
GeneOntologyMolecularFunction	antiporter activity	SLC44A2 SLC24A1	6.02e-03	138	17	2	GO:0015297
GeneOntologyMolecularFunction	symporter activity	SLC24A1 SLC28A3	7.08e-03	150	17	2	GO:0015293
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC24A1 SLC28A3	9.11e-03	171	17	2	GO:0015081
GeneOntologyMolecularFunction	metallopeptidase activity	MBTPS2 PRPF8	1.23e-02	200	17	2	GO:0008237
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC44A2 SLC24A1 ABCA13 SLC28A3	1.55e-02	1180	17	4	GO:0022857
GeneOntologyMolecularFunction	peptidase activity	MBTPS2 PRPF8 USP34	1.69e-02	654	17	3	GO:0008233
Domain	DUF2370	NDFIP2 NDFIP1	7.80e-07	2	17	2	PF10176
Domain	NEDD4/Bsd2	NDFIP2 NDFIP1	7.80e-07	2	17	2	IPR019325
Domain	-	MBTPS2 AFDN	8.05e-03	150	17	2	2.30.42.10
Domain	PDZ	MBTPS2 AFDN	8.26e-03	152	17	2	IPR001478
Pubmed	Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.	NDFIP2 NDFIP1	6.74e-07	3	17	2	19343052
Pubmed	Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).	NDFIP2 NDFIP1	1.35e-06	4	17	2	26363003
Pubmed	Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.	NDFIP2 NDFIP1	1.35e-06	4	17	2	27088444
Pubmed	Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.	NDFIP2 NDFIP1	2.25e-06	5	17	2	18776082
Pubmed	N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.	NDFIP2 NDFIP1	3.37e-06	6	17	2	11748237
Pubmed	Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.	NDFIP2 NDFIP1	6.29e-06	8	17	2	20534535
Pubmed	Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord.	NDFIP2 NDFIP1	6.29e-06	8	17	2	30893602
Pubmed	Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.	SLC44A2 NDFIP2 NDFIP1	1.26e-05	94	17	3	12761501
Pubmed	NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation.	NDFIP2 NDFIP1	7.84e-05	27	17	2	28931009
Pubmed	MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.	NDFIP2 NDFIP1	1.73e-04	40	17	2	30759391
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ELOVL1 PRPF8 USP34 CLUH AFDN	2.15e-04	1203	17	5	29180619
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PRPF8 USP34 CLUH AFDN	2.41e-04	653	17	4	22586326
Pubmed	Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress.	USP34 UBR3	3.91e-04	60	17	2	26472337
Interaction	FAM8A1 interactions	MBTPS2 NDFIP2 NDFIP1	1.77e-05	70	15	3	int:FAM8A1
Cytoband	17p13.3	PRPF8 CLUH	4.85e-04	88	17	2	17p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	PRPF8 CLUH	7.15e-03	346	17	2	chr17p13
GeneFamily	Solute carriers	SLC44A2 SLC24A1 SLC28A3 SLC35F4	4.25e-05	395	10	4	752
ToppCell	critical-Epithelial\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ABCA13 NDFIP2 AFDN	5.54e-05	199	17	3	bbb44e2a52f102a6d891ead6c06d6c07221abd33
ToppCell	NS-critical-d_07-13-Epithelial\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ABCA13 NDFIP2 AFDN	5.54e-05	199	17	3	b88a81cd2a89f4d27100c96ae4324dcee68daf83
ToppCell	control-Epithelial\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ABCA13 NDFIP2 AFDN	5.62e-05	200	17	3	f95bbb94e51ac28b1995026c599ec3a34e012916
ToppCell	NS-control-d_0-4-Epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ABCA13 NDFIP2 AFDN	5.62e-05	200	17	3	d014959891893b6d3854a471fba1dc50c6625a0a
Disease	longitudinal BMI measurement	SLC28A3 NDFIP1 SLC35F4	1.13e-05	82	16	3	EFO_0005937
Disease	caudate volume change measurement, age at assessment	UBR3 SLC28A3	9.60e-05	27	16	2	EFO_0008007, EFO_0021491
Disease	reticulocyte measurement	SLC44A2 PRPF8 USP34 AFDN DPY19L3	1.80e-04	1053	16	5	EFO_0010700
Disease	unipolar depression, mood disorder	CLUH DPY19L3	2.36e-03	134	16	2	EFO_0003761, EFO_0004247
Disease	bipolar disorder	SLC44A2 DPY19L3 SLC35F4	3.45e-03	577	16	3	MONDO_0004985
Disease	multiple sclerosis	SLC44A2 TRAM1 NDFIP1	3.74e-03	594	16	3	MONDO_0005301
Disease	DNA methylation	ABCA13 NDFIP1 SLC35F4	4.94e-03	656	16	3	GO_0006306
Disease	Disorder of eye	PRPF8 SLC24A1	5.77e-03	212	16	2	C0015397

Protein segments in the cluster

Peptide	Gene	Start	Entry
LFSQLFHFINMWLFN	AFDN	786	P55196
NNVGFFFPLIMMLTW	ABCA13	3566	Q86UQ4
TFLFSLTWQFNQFMM	DPY19L3	251	Q6ZPD9
FFVFTFLGSIMWIAM	SLC24A1	936	O60721
GLSNSWELQMFFFMV	OR4K2	16	Q8NGD2
GIFMLAFFMAFIFNW	NDFIP2	231	Q9NV92
GIFMLTFFMAFLFNW	NDFIP1	116	Q9BT67
IWMYGTIFFMLFSNF	ELOVL1	236	Q9BW60
MLYQWFNFGMVFGVI	MBTPS2	71	O43462
ALLGLQIFNAFMFFW	SLC44A2	441	Q8IWA5
QIFNAFMFFWLANFV	SLC44A2	446	Q8IWA5
FMFFWLANFVLALGQ	SLC44A2	451	Q8IWA5
LSFMNSALSWFGNMF	SLC28A3	461	Q9HAS3
FFMTWFSTNWNIMFF	SLC35F4	196	A4IF30
MQMFIWNNIFFSLGF	CLUH	416	O75153
FMVPAQSSWNYNFMG	PRPF8	2271	Q6P2Q9
VTQAFMMWKFINFQL	TRAM1	306	Q15629
LLVTWMNFVSFFQGM	UBR3	536	Q6ZT12
LQDNGSFLWFSMMSQ	ZBED9	186	Q6R2W3
MFSTYFMDLWNLFQP	USP34	2771	Q70CQ2