Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OR8U8 OR10A3 OR2T3 OR52I2 OR5J2 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

2.47e-1343115323GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OPRD1 OPRK1 OR8U8 OPRM1 OR10A3 OR2T3 LHCGR GPR161 OR52I2 OR5J2 P2RY1 OR1A1 TAS1R2 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

5.13e-1288415330GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR2T34 OR5M8 CHRNA1 CHRNB4 OR8U9 OPRD1 OPRK1 OR8U8 OPRM1 OR10A3 OR2T3 LHCGR GPR161 OR52I2 OR5J2 PTPRB P2RX5 P2RY1 PTPRZ1 OR1A1 TAS1R2 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.32e-10135315335GO:0004888
GeneOntologyMolecularFunctionodorant binding

OR8U1 OR5AK2 OR5AK3P OR8U3 OR5M8 OR8U9 OR8U8 OR5J2

6.14e-061271538GO:0005549
GeneOntologyMolecularFunctionG protein-coupled opioid receptor activity

OPRD1 OPRK1 OPRM1

1.51e-0571533GO:0004985
GeneOntologyMolecularFunctiontransporter activity

SLC25A24 SFXN4 CACNA1S ATP13A1 ESYT1 ATP13A5 SLC1A1 CHRNA1 RYR3 CHRNB4 OPRM1 SLC10A1 CLCN6 P2RX5 SLC15A1 GET3 PITPNM3 KCNQ2 SLC13A5 CACNA1I ABCC12 ATP11A SLC25A23 UNC80

4.60e-05128915324GO:0005215
GeneOntologyMolecularFunctionADP:phosphate antiporter activity

SLC25A24 SLC25A23

5.83e-0521532GO:0140988
GeneOntologyMolecularFunctionmedium-chain fatty acid omega-hydroxylase activity

CYP4A11 CYP4A22

5.83e-0521532GO:0140981
GeneOntologyMolecularFunction16-hydroxypalmitate dehydrogenase activity

CYP4A11 CYP4A22

5.83e-0521532GO:0103002
GeneOntologyMolecularFunctionATP-dependent activity

UBA5 SPG7 MYO9A ATP13A1 ATP13A5 YTHDC2 MORC4 DNAH12 GET3 UBA6 SMARCA4 ABCC12 ATP11A MYO15A DDX28

7.76e-0561415315GO:0140657
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SFXN4 CACNA1S ATP13A1 ATP13A5 SLC1A1 CHRNA1 RYR3 CHRNB4 OPRM1 SLC10A1 CLCN6 P2RX5 SLC15A1 KCNQ2 SLC13A5 CACNA1I UNC80

1.26e-0479315317GO:0015075
GeneOntologyMolecularFunctionaromatase activity

CYP2E1 CYP3A4 CYP4A11 CYP4A22

1.44e-04351534GO:0070330
GeneOntologyMolecularFunctionATP:phosphate antiporter activity

SLC25A24 SLC25A23

1.74e-0431532GO:0140987
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1S ATP13A1 ATP13A5 SLC1A1 CHRNA1 RYR3 CHRNB4 OPRM1 SLC10A1 P2RX5 SLC15A1 KCNQ2 SLC13A5 CACNA1I UNC80

1.83e-0466415315GO:0008324
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC25A24 SFXN4 CACNA1S ATP13A1 ATP13A5 SLC1A1 CHRNA1 RYR3 CHRNB4 OPRM1 SLC10A1 CLCN6 P2RX5 SLC15A1 GET3 KCNQ2 SLC13A5 CACNA1I ABCC12 SLC25A23 UNC80

2.67e-04118015321GO:0022857
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2E1 CYP3A4 CYP4A11 CYP4A22

5.37e-04491534GO:0016712
GeneOntologyMolecularFunctionhistone H3K27me2/H3K27me3 demethylase activity

KDM6A UTY

5.75e-0451532GO:0071558
GeneOntologyMolecularFunctionATP hydrolysis activity

SPG7 ATP13A1 ATP13A5 YTHDC2 MORC4 DNAH12 GET3 SMARCA4 ABCC12 ATP11A DDX28

6.06e-0444115311GO:0016887
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP2E1 CYP3A4 CYP4A11 PHYHD1 CYP4A22 KDM6A UTY

7.53e-041941537GO:0016705
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP2E1 CYP4A11 CYP4A22

7.93e-04241533GO:0008392
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1S SLC1A1 CHRNA1 RYR3 CHRNB4 OPRM1 CLCN6 P2RX5 KCNQ2 CACNA1I UNC80

8.41e-0445915311GO:0005216
GeneOntologyMolecularFunctiongated channel activity

CACNA1S CHRNA1 RYR3 CHRNB4 OPRM1 CLCN6 P2RX5 KCNQ2 CACNA1I

1.12e-033341539GO:0022836
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP2E1 CYP4A11 CYP4A22

1.13e-03271533GO:0008391
GeneOntologyMolecularFunctionorganophosphate:phosphate antiporter activity

SLC25A24 SLC25A23

1.19e-0371532GO:0015315
GeneOntologyMolecularFunctionleukotriene-B4 20-monooxygenase activity

CYP4A11 CYP4A22

1.19e-0371532GO:0050051
GeneOntologyMolecularFunctionalkane 1-monooxygenase activity

CYP4A11 CYP4A22

1.19e-0371532GO:0018685
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1S CHRNA1 RYR3 CHRNB4 OPRM1 P2RX5 KCNQ2 CACNA1I UNC80

1.34e-033431539GO:0005261
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC25A24 CACNA1S ATP13A1 SLC1A1 RYR3 OPRM1 SLC10A1 CLCN6 SLC15A1 GET3 KCNQ2 SLC13A5 CACNA1I SLC25A23

2.11e-0375815314GO:0015318
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC1A1 SLC10A1 SLC13A5

2.41e-03351533GO:0005343
GeneOntologyMolecularFunctionreceptor serine/threonine kinase binding

OPRD1 OPRK1 NEO1

2.41e-03351533GO:0033612
GeneOntologyMolecularFunctionchannel activity

CACNA1S SLC1A1 CHRNA1 RYR3 CHRNB4 OPRM1 CLCN6 P2RX5 KCNQ2 CACNA1I UNC80

2.44e-0352515311GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1S SLC1A1 CHRNA1 RYR3 CHRNB4 OPRM1 CLCN6 P2RX5 KCNQ2 CACNA1I UNC80

2.47e-0352615311GO:0022803
GeneOntologyMolecularFunctionarachidonate omega-hydroxylase activity

CYP4A11 CYP4A22

2.52e-03101532GO:0052869
GeneOntologyMolecularFunctionfatty acid omega-hydroxylase activity

CYP4A11 CYP4A22

2.52e-03101532GO:0120250
GeneOntologyMolecularFunctionubiquitin-like modifier activating enzyme activity

UBA5 UBA6

2.52e-03101532GO:0008641
GeneOntologyMolecularFunctionlong-chain fatty acid omega-hydroxylase activity

CYP4A11 CYP4A22

2.52e-03101532GO:0102033
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1S OPRM1 CLCN6 P2RX5 KCNQ2 CACNA1I

2.82e-031821536GO:0005244
GeneOntologyMolecularFunctionneuropeptide binding

OPRD1 OPRK1 OPRM1

2.83e-03371533GO:0042923
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1S OPRM1 CLCN6 P2RX5 KCNQ2 CACNA1I

2.98e-031841536GO:0022832
GeneOntologyMolecularFunctionADP transmembrane transporter activity

SLC25A24 SLC25A23

3.07e-03111532GO:0015217
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OR8U8 OR10A3 OR2T3 OR52I2 OR5J2 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.00e-1343215123GO:0050911
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OR8U8 OR10A3 OR2T3 OR52I2 OR5J2 OR1A1 TAS1R2 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.36e-1348515124GO:0050907
GeneOntologyBiologicalProcesssensory perception

OR8U1 OR9A4 OR5AK2 DHRS3 OR4S2 MYO9A OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OPRK1 OR8U8 OPRM1 OR10A3 OR2T3 OR52I2 ATF6 ABLIM1 OR5J2 OR1A1 TAS1R2 KCNQ2 OR4C12 OR52M1 OR2V2 MYO15A TBX1 CLRN2 OR4F6 OR1L4

2.72e-13107215134GO:0007600
GeneOntologyBiologicalProcesssensory perception of smell

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OR8U8 OR10A3 OR2T3 OR52I2 OR5J2 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

4.64e-1346515123GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OR8U8 OR10A3 OR2T3 OR52I2 OR5J2 OR1A1 TAS1R2 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

7.16e-1352415124GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OR8U8 OR10A3 OR2T3 OR52I2 OR5J2 OR1A1 TAS1R2 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.79e-1254715124GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OR8U8 OR10A3 OR2T3 OR52I2 OR5J2 OR1A1 TAS1R2 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

6.61e-1258215124GO:0050906
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR2T34 OR5M8 SLC1A1 ADCY2 PREX2 OR8U9 OPRD1 OPRK1 OR8U8 OPRM1 OR10A3 OR2T3 LHCGR GPR161 OR52I2 NLN OR5J2 P2RY1 OR1A1 TAS1R2 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

3.63e-10139515134GO:0007186
GeneOntologyBiologicalProcessdetection of stimulus

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OR8U8 OR10A3 OR2T3 OR52I2 OR5J2 OR1A1 TAS1R2 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

5.48e-1072215124GO:0051606
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SFXN4 CACNA1S RELN NEDD4L SPG7 ATP13A1 ATP13A5 SLC1A1 CHRNA1 RYR3 CHRNB4 OPRK1 OPRM1 LHCGR CLCN6 P2RX5 SLC15A1 KCNQ2 SLC13A5 CACNA1I SLC25A23 UNC80 PCYOX1

6.51e-06111515123GO:0034220
GeneOntologyBiologicalProcessmonoatomic ion transport

SFXN4 CACNA1S RELN NEDD4L SPG7 ATP13A1 ATP13A5 SLC1A1 CHRNA1 RYR3 CHRNB4 OPRD1 OPRK1 OPRM1 LHCGR SLC10A1 CLCN6 P2RX5 P2RY1 SLC15A1 KCNQ2 SLC13A5 CACNA1I SLC25A23 UNC80 PCYOX1

7.14e-06137415126GO:0006811
GeneOntologyBiologicalProcesslipid hydroxylation

CYP2E1 CYP3A4 CYP4A22

3.13e-0591513GO:0002933
GeneOntologyBiologicalProcesseating behavior

OPRD1 OPRK1 OPRM1 P2RY1 TTC21B

5.56e-05561515GO:0042755
GeneOntologyBiologicalProcessresponse to nicotine

CHRNA1 CHRNB4 OPRD1 OPRK1 VCAM1

6.60e-05581515GO:0035094
GeneOntologyBiologicalProcessG protein-coupled opioid receptor signaling pathway

OPRD1 OPRK1 OPRM1

1.04e-04131513GO:0038003
GeneOntologyBiologicalProcesscellular response to purine-containing compound

CACNA1S RYR3 P2RY1

1.32e-04141513GO:0071415
GeneOntologyBiologicalProcessadenylate cyclase-inhibiting opioid receptor signaling pathway

OPRK1 OPRM1

1.59e-0431512GO:0031635
GeneOntologyBiologicalProcesslauric acid metabolic process

CYP4A11 CYP4A22

1.59e-0431512GO:0048252
GeneOntologyBiologicalProcesscellular response to alkaloid

CACNA1S SLC1A1 RYR3 OPRM1

2.05e-04401514GO:0071312
GeneOntologyBiologicalProcesslocomotory behavior

RELN SLC1A1 PREX2 CHRNB4 OPRD1 OPRK1 OPRM1 UBA6 MYO15A

2.52e-042841519GO:0007626
GeneOntologyBiologicalProcessglial cell migration

RELN SUN1 PTPRB P2RY1 PTPRZ1

3.04e-04801515GO:0008347
GeneOntologyBiologicalProcessmonoatomic cation transport

CACNA1S NEDD4L SPG7 ATP13A1 ATP13A5 SLC1A1 CHRNA1 RYR3 OPRD1 OPRK1 OPRM1 LHCGR SLC10A1 P2RX5 SLC15A1 KCNQ2 SLC13A5 CACNA1I SLC25A23 UNC80

3.05e-04115715120GO:0006812
GeneOntologyBiologicalProcessadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

ADCY2 OPRD1 OPRK1 OPRM1 P2RY1

4.25e-04861515GO:0007193
GeneOntologyBiologicalProcessregulation of carbohydrate biosynthetic process

SERPINA12 OPRM1 PRKAG3 LHCGR NLN P2RY1

4.28e-041321516GO:0043255
DomainGPCR_Rhodpsn_7TM

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OPRD1 OPRK1 OR8U8 OPRM1 OR10A3 OR2T3 LHCGR GPR161 OR52I2 OR5J2 P2RY1 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

8.48e-1367015228IPR017452
DomainOlfact_rcpt

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OR8U8 OR10A3 OR2T3 OR52I2 OR5J2 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.06e-1239315222IPR000725
Domain7tm_1

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OPRD1 OPRK1 OR8U8 OPRM1 OR10A3 OR2T3 LHCGR GPR161 OR52I2 OR5J2 P2RY1 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.09e-1267715228PF00001
DomainG_PROTEIN_RECEP_F1_1

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OPRD1 OPRK1 OR8U8 OPRM1 OR10A3 OR2T3 LHCGR GPR161 OR52I2 OR5J2 P2RY1 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.45e-1268515228PS00237
DomainG_PROTEIN_RECEP_F1_2

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OPRD1 OPRK1 OR8U8 OPRM1 OR10A3 OR2T3 LHCGR GPR161 OR52I2 OR5J2 P2RY1 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.78e-1269115228PS50262
DomainGPCR_Rhodpsn

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OPRD1 OPRK1 OR8U8 OPRM1 OR10A3 OR2T3 LHCGR GPR161 OR52I2 OR5J2 P2RY1 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.84e-1269215228IPR000276
DomainOpioid_rcpt

OPRD1 OPRK1 OPRM1

2.10e-0641523IPR001418
DomainFam133

FAM133A FAM133B

6.58e-0521522IPR026766
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OR8U8 OR10A3 OR2T3 OR52I2 OR5J2 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

9.76e-1241712322M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR1A2 OR8U3 OR2T34 OR5M8 OR8U8 OR10A3 OR2T3 OR52I2 OR5J2 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.99e-1138912321M14091
PathwayREACTOME_SENSORY_PERCEPTION

OR8U1 OR9A4 OR5AK2 DHRS3 OR4S2 OR13C8 OR2W1 OR1A2 OR8U3 OR2T34 OR5M8 OR8U9 OR8U8 OR10A3 OR2T3 OR52I2 OR5J2 OR1A1 TAS1R2 OR4C12 OR52M1 OR2V2 MYO15A OR4F6 OR1L4

1.84e-1063612325M41834
PathwayBIOCARTA_NUCLEARRS_PATHWAY

CYP2E1 CYP3A4 CYP4A11 CYP4A22

1.86e-04331234MM1448
PathwayWP_GPCRS_OTHER

OR8U1 OR2W1 OR1A2 OPRK1 OPRM1 OR1A1

1.91e-04961236MM15939
PathwayBIOCARTA_NUCLEARRS_PATHWAY

CYP2E1 CYP3A4 CYP4A11 CYP4A22

2.09e-04341234M16393
PathwayKEGG_RETINOL_METABOLISM

DHRS3 CYP3A4 CYP4A11 CYP4A22 UGT1A3

2.36e-04641235M9488
PathwayWP_FATTY_ACID_OMEGAOXIDATION

CYP2E1 CYP3A4 CYP4A11

2.73e-04151233M39717
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR2W1 OR1A2 OR10A3 OR1A1 OR4C12

3.59e-04701235MM14984
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OR2W1 OR1A2 OPRD1 OPRK1 OPRM1 LHCGR GPR161 P2RY1 OR1A1

4.54e-042601239M39397
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP3A4 CYP4A11 CYP4A22

4.81e-04181233MM14843
PathwayREACTOME_MECP2_REGULATES_NEURONAL_RECEPTORS_AND_CHANNELS

OPRK1 OPRM1 PTPN4

4.81e-04181233M27901
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR5M8 OR10A3 OR52I2 OR5J2 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.12e-153401541911875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR5M8 OR10A3 OR52I2 OR5J2 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.12e-153401541911802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR5M8 OR10A3 OR52I2 OR5J2 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.32e-153431541932295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR8U1 OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR5AK3P OR1A2 OR8U3 OR5M8 OR10A3 OR52I2 OR5J2 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

1.55e-153461541914611657
Pubmed

The human olfactory receptor gene family.

OR9A4 OR5AK2 OR4S2 OR13C8 OR2W1 OR1A2 OR8U3 OR2T34 OR5M8 OR10A3 OR52I2 OR5J2 OR1A1 OR4C12 OR52M1 OR2V2 OR4F6 OR1L4

4.02e-115411541814983052
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR4S2 OR13C8 OR2W1 OR1A2 OR2T34 OR5M8 OR10A3 OR1A1 OR4C12 OR2V2 OR1L4

4.38e-092191541112213199
Pubmed

Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice.

OPRD1 OPRK1 OPRM1

8.51e-083154310082819
Pubmed

Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers.

OPRD1 OPRK1 OPRM1

8.51e-083154318537939
Pubmed

Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones.

OPRD1 OPRK1 OPRM1

8.51e-083154312603260
Pubmed

No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse.

OPRD1 OPRK1 OPRM1

8.51e-083154315178356
Pubmed

Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.

OPRD1 OPRK1 OPRM1

8.51e-08315438114680
Pubmed

Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.

OPRD1 OPRK1 OPRM1

8.51e-083154311032994
Pubmed

Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice.

OPRD1 OPRK1 OPRM1

8.51e-083154325855262
Pubmed

Opioid receptors: from binding sites to visible molecules in vivo.

OPRD1 OPRK1 OPRM1

8.51e-083154318718480
Pubmed

Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations.

OPRD1 OPRK1 OPRM1

8.51e-083154318213616
Pubmed

Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.

OPRD1 OPRK1 OPRM1

8.51e-083154311069979
Pubmed

Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*.

OPRD1 OPRK1 OPRM1

8.51e-083154319032295
Pubmed

The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice.

OPRD1 OPRK1 OPRM1

8.51e-083154315090050
Pubmed

Cell-specific actions of HIV-Tat and morphine on opioid receptor expression in glia.

OPRD1 OPRK1 OPRM1

8.51e-083154318338799
Pubmed

Long-term alterations in mu, delta and kappa opioidergic receptors following middle cerebral artery occlusion in mice.

OPRD1 OPRK1 OPRM1

8.51e-083154317676326
Pubmed

Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms.

OPRD1 OPRK1 OPRM1

8.51e-083154326692286
Pubmed

Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.

OPRD1 OPRK1 OPRM1

8.51e-083154317374034
Pubmed

Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity.

OPRD1 OPRK1 OPRM1

8.51e-083154311504820
Pubmed

Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice.

OPRD1 OPRK1 OPRM1

8.51e-083154312431223
Pubmed

The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation.

OPRD1 OPRK1 OPRM1

8.51e-083154328049031
Pubmed

Modelling the PKPD of oxycodone in experimental pain - Impact of opioid receptor polymorphisms.

OPRD1 OPRK1 OPRM1

8.51e-083154326946441
Pubmed

Nociception increases during opioid infusion in opioid receptor triple knock-out mice.

OPRD1 OPRK1 OPRM1

8.51e-083154317544222
Pubmed

Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han.

OPRD1 OPRK1 OPRM1

8.51e-083154314745298
Pubmed

Opioid receptor characterisation of neuronally stimulated isolated human vas deferens.

OPRD1 OPRK1 OPRM1

8.51e-083154322752269
Pubmed

Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence.

OPRD1 OPRK1 OPRM1

8.51e-083154324874714
Pubmed

Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.

OPRD1 OPRK1 OPRM1

8.51e-083154311826143
Pubmed

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.

OPRD1 OPRK1 OPRM1

8.51e-083154333555255
Pubmed

Enhanced humoral response in kappa-opioid receptor knockout mice.

OPRD1 OPRK1 OPRM1

8.51e-083154312507774
Pubmed

Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration.

OPRD1 OPRK1 OPRM1

8.51e-083154314975676
Pubmed

Identification of ligands for olfactory receptors by functional expression of a receptor library.

OR8U1 OR2W1 OR1A2 OR1A1

1.78e-071215449875846
Pubmed

Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells.

OPRD1 OPRK1 OPRM1

3.39e-074154312413885
Pubmed

Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse.

OPRD1 OPRK1 OPRM1

3.39e-07415439502813
Pubmed

Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene.

OPRD1 OPRK1 OPRM1

3.39e-074154311430857
Pubmed

A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline.

OPRD1 OPRK1 OPRM1

3.39e-074154330249798
Pubmed

Multiple opioid receptor-like genes are identified in diverse vertebrate phyla.

OPRD1 OPRK1 OPRM1

3.39e-07415438941707
Pubmed

Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.

CYP2E1 CYP4A11 CYP4A22

3.39e-074154310049703
Pubmed

Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells.

OPRD1 OPRK1 OPRM1

3.39e-074154316053916
Pubmed

Identification and characterization of novel candidate compounds targeting 6- and 7-transmembrane μ-opioid receptor isoforms.

OPRD1 OPRK1 OPRM1

8.46e-075154333782947
Pubmed

Variations in opioid receptor genes in neonatal abstinence syndrome.

OPRD1 OPRK1 OPRM1

8.46e-075154326233486
Pubmed

Genetic susceptibility to heroin addiction: a candidate gene association study.

OPRD1 OPRK1 OPRM1

1.69e-066154318518925
Pubmed

Opioid receptor gene expression in dopamine transporter knock-out mice in adult and during development.

OPRD1 OPRK1 OPRM1

1.69e-066154312044478
Pubmed

Expression of opioid receptors and ligands in pregnant mouse uterus and placenta.

OPRD1 OPRK1 OPRM1

1.69e-06615439746745
Pubmed

Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.

CYP2E1 CYP4A11 CYP4A22

2.94e-067154312958197
Pubmed

HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.

CUL2 UBA5 UBE4B ANAPC2 UBA6 SYVN1

3.13e-0690154635671810
Pubmed

Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.

CYP3A4 CYP4A11 CYP4A22

4.69e-068154318488193
Pubmed

Preimplantation mouse embryo is a target for opioid ligand-receptor signaling.

OPRD1 OPRK1 OPRM1

4.69e-068154324855103
Pubmed

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.

SMARCA4 KDM6A UTY

7.01e-069154323028370
Pubmed

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.

CYP3A4 CYP4A11 CYP4A22

7.01e-06915437678494
Pubmed

Dissociation of the opioid receptor mechanisms that control mechanical and heat pain.

OPRD1 OPRM1

1.95e-052154219524516
Pubmed

Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.

CYP4A11 CYP4A22

1.95e-052154215611369
Pubmed

Activation of µ-δ opioid receptor heteromers inhibits neuropathic pain behavior in rodents.

OPRD1 OPRM1

1.95e-052154231815916
Pubmed

Differential involvement of the mu and kappa opioid receptors in spatial learning.

OPRK1 OPRM1

1.95e-052154212884965
Pubmed

Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice.

OPRK1 OPRM1

1.95e-052154228512665
Pubmed

Involvement of delta and mu opioid receptors in the acute and sensitized locomotor action of cocaine in mice.

OPRD1 OPRM1

1.95e-052154223965295
Pubmed

Association Between Genetic Polymorphisms and Pain Sensitivity in Patients with Hip Osteoarthritis.

OPRD1 OPRM1

1.95e-052154229055075
Pubmed

The conserved cysteine 7.38 residue is differentially accessible in the binding-site crevices of the mu, delta, and kappa opioid receptors.

OPRD1 OPRM1

1.95e-052154211076532
Pubmed

An H-YDb epitope is encoded by a novel mouse Y chromosome gene.

KDM6A UTY

1.95e-05215428944031
Pubmed

Ligands raise the constraint that limits constitutive activation in G protein-coupled opioid receptors.

OPRD1 OPRM1

1.95e-052154223836900
Pubmed

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

OPRD1 OPRK1

1.95e-05215428393575
Pubmed

μ-Opioid receptor antibody reveals tissue-dependent specific staining and increased neuronal μ-receptor immunoreactivity at the injured nerve trunk in mice.

OPRD1 OPRK1

1.95e-052154224278116
Pubmed

Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.

CYP4A11 CYP4A22

1.95e-052154223641057
Pubmed

Regulations of opioid dependence by opioid receptor types.

OPRD1 OPRK1

1.95e-052154211316510
Pubmed

The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.

CYP4A11 CYP4A22

1.95e-052154228912346
Pubmed

Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.

CYP4A11 CYP4A22

1.95e-052154224413902
Pubmed

Contrasting effects of mu opioid receptor and delta opioid receptor deletion upon the behavioral and neurochemical effects of cocaine.

OPRD1 OPRM1

1.95e-052154215262338
Pubmed

Increased abundance of opioid receptor heteromers after chronic morphine administration.

OPRD1 OPRM1

1.95e-052154220647592
Pubmed

Activation of mu-opioid receptors are required for the conditioned enhancement of NK cell activity.

OPRD1 OPRM1

1.95e-05215428930374
Pubmed

Differential stability of the crystallographic interfaces of mu- and kappa-opioid receptors.

OPRK1 OPRM1

1.95e-052154224651466
Pubmed

The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.

OPRD1 OPRK1

1.95e-052154217622222
Pubmed

KDM6A point mutations cause Kabuki syndrome.

SMARCA4 KDM6A

1.95e-052154223076834
Pubmed

Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.

CYP4A11 CYP4A22

1.95e-05215428031839
Pubmed

Potentiation of dopamine D1-like receptor signaling by concomitant activation of δ- and μ-opioid receptors in mouse medial prefrontal cortex.

OPRD1 OPRM1

1.95e-052154223073238
Pubmed

Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.

CYP4A11 CYP4A22

1.95e-052154210860550
Pubmed

Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses.

OPRD1 OPRM1

1.95e-052154210835636
Pubmed

Differential response to morphine of the oligomeric state of μ-opioid in the presence of δ-opioid receptors.

OPRD1 OPRM1

1.95e-052154221361347
Pubmed

μ- and δ-opioid-related processes in the accumbens core and shell differentially mediate the influence of reward-guided and stimulus-guided decisions on choice.

OPRD1 OPRM1

1.95e-052154222302826
Pubmed

delta-, but not mu-, opioid receptor stabilizes K(+) homeostasis by reducing Ca(2+) influx in the cortex during acute hypoxia.

OPRD1 OPRM1

1.95e-052154217373650
Pubmed

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.

CYP4A11 CYP4A22

1.95e-052154211320253
Pubmed

Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice.

OPRD1 OPRM1

1.95e-052154214622224
Pubmed

Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2.

OR1A2 OR1A1

1.95e-052154217601748
Pubmed

Modification of CYP2E1 and CYP3A4 activities in haemoglobin E-beta thalassemia patients.

CYP2E1 CYP3A4

1.95e-052154217119944
Pubmed

Mu and delta opioid receptor knockout mice show increased colonic sensitivity.

OPRD1 OPRM1

1.95e-052154227748566
Pubmed

Characterization of the CYP4A11 gene, a second CYP4A gene in humans.

CYP4A11 CYP4A22

1.95e-052154212464262
Pubmed

Ligand directed signaling differences between rodent and human κ-opioid receptors.

OPRK1 OPRM1

1.95e-052154223086943
Pubmed

Expression of delta- and mu-opioid receptors in the ventricular and subventricular zones of the developing human neocortex.

OPRD1 OPRM1

1.95e-052154218455254
Pubmed

Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation.

CYP2E1 CYP3A4

1.95e-052154223530020
Pubmed

Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.

CYP4A11 CYP4A22

1.95e-052154215066132
Pubmed

Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons.

OPRD1 OPRM1

1.95e-052154219357247
Pubmed

Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions.

OPRD1 OPRM1

1.95e-052154215657030
Pubmed

Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.

OPRD1 OPRM1

1.95e-052154220615975
Pubmed

Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.

OPRD1 OPRM1

1.95e-052154235674691
Pubmed

κ Opioid Receptor 1 Single Nucleotide Polymorphisms were Associated with the Methadone Dosage.

OPRK1 OPRM1

1.95e-052154231940240
Pubmed

The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions.

OPRD1 OPRK1

1.95e-052154216331961
Pubmed

20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.

CYP4A11 CYP4A22

1.95e-052154223825080
Pubmed

Effect of CYP3A4*18B polymorphisms and interactions with OPRM1 A118G on postoperative fentanyl requirements in patients undergoing radical gastrectomy.

CYP3A4 OPRM1

1.95e-052154223313934
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR8U1 OR5AK2 OR5AK3P OR8U3 OR5M8 OR5J2 FEN1

1.76e-043451547chr11q12
Cytoband11q12.1

OR8U1 OR5AK2 OR5AK3P OR8U3 OR5M8

2.21e-04161154511q12.1
Cytoband11q11

OR4S2 OR8U8 OR5J2

5.39e-0447154311q11
CytobandEnsembl 112 genes in cytogenetic band chr18q21

NEDD4L SEC11C SERPINB12 SERPINB2 PHLPP1

6.67e-042051545chr18q21
GeneFamilyOpioid receptors

OPRD1 OPRK1 OPRM1

8.73e-0741103245
GeneFamilyParkinson disease associated genes|ATPase orphan transporters

ATP13A1 ATP13A5

3.62e-04511021213
GeneFamilyOlfactory receptors, family 5

OR5AK2 OR5AK3P OR8U3 OR5M8 OR5J2

6.09e-041121105152
GeneFamilySerpin peptidase inhibitors

SERPINA12 SERPINB12 SERPINB2

1.46e-03371103739
GeneFamilyUbiquitin like modifier activating enzymes

UBA5 UBA6

1.60e-03101102100
GeneFamilyOlfactory receptors, family 1

OR1A2 OR1A1 OR1L4

1.84e-03401103147
GeneFamilyOlfactory receptors, family 8

OR8U1 OR8U9 OR8U8

3.29e-03491103155
GeneFamilyCholinergic receptors nicotinic subunits

CHRNA1 CHRNB4

4.16e-03161102173
GeneFamilyOlfactory receptors, family 2

OR2W1 OR2T34 OR2T3 OR2V2

5.02e-031131104149
GeneFamilyT-boxes

TBX4 TBX1

5.27e-03181102766
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

SAMD5 RALGAPA2 PREX2 ABLIM1 PTPRB GFOD1 VCAM1

3.57e-061871517e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

SAMD5 RALGAPA2 PREX2 ABLIM1 PTPRB GFOD1 VCAM1

3.69e-061881517d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SEC11C SLC1A1 TENM2 OPRK1 MARVELD3 MUC5AC TBX1

4.10e-06191151705731ece7867659c662f952812805f947032fe10
ToppCellTCGA-Lung-Primary_Tumor|TCGA-Lung / Sample_Type by Project: Shred V9

SFXN4 TMEM69 RMI2 NLN BUB1 FEN1 IQGAP3

5.37e-061991517d1d035e987280607266171094db5d6362efe1ad5
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

SFXN4 TMEM69 RMI2 NLN BUB1 FEN1 IQGAP3

5.37e-0619915176748d4f76703360071d5f2026d9d06bf30ccfb6d
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Vein|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PHYHD1 RALGAPA2 PREX2 ABLIM1 FRY PTPRB VCAM1

5.55e-0620015177eb366b2c5394af7c77650bde6261e7dac67154e
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CYP3A4 ADCY2 PREX2 RYR3 ABLIM1 SLC13A5 PYGM

5.55e-06200151707d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCellCOVID-19-kidney-Technical/muscle_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

RELN TBX4 PREX2 MALRD1 PTPRB OR4C12

8.04e-06139151664c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC10A1 MALRD1 FEN1 ACP4 MARVELD3 DDX28

9.09e-0614215165690eee2ce1ecd02e34eac4193578bd13c4228b9
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A5 ADCY2 RYR3 PTPRZ1 ABCC12 UNC80

1.79e-051601516c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A5 ADCY2 RYR3 PTPRZ1 ABCC12 UNC80

1.79e-05160151625c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SAMD5 RALGAPA2 SLC1A1 PTPRB P2RY1 PHLPP1

2.44e-051691516f086b50791e1c93e253eb5e8d6c4bf617b1416c3
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SZT2 ESYT1 PREX2 ABLIM1 PTPRB GFOD1

2.52e-05170151655fe16d98ea284d05fb899888e4569c685644c7b
ToppCellAT1-AT2_cells-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

NEDD4L PHYHD1 SLC1A1 ABLIM1 SLC25A23 PCYOX1

3.58e-051811516ca23ce4f2c7b684d8ddd0e8619b3b696023d75e3
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SLC1A1 OPRK1 FRY SLC15A1 MARVELD3 TBX1

3.81e-051831516c5b10571599dc26476170b54b53f09c23e6b3117
ToppCellControl-Endothelial_cells-Pulmonary_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

SAMD5 RALGAPA2 PREX2 ABLIM1 PTPRB VCAM1

3.81e-05183151646be9f96755c7b65aeac061d95d15abeb6466034
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CYP4A11 ADCY2 SNX29 ABLIM1 SLC15A1 ATP11A

4.17e-051861516b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

SAMD5 RALGAPA2 PREX2 ABLIM1 PTPRB VCAM1

4.30e-0518715162d20193a6cacdfa4877457c97b0077408942186c
ToppCellControl-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

SAMD5 RALGAPA2 PREX2 ABLIM1 PTPRB VCAM1

4.56e-051891516f83f7521e377ded1522639e9a35c98b3e2725bac
ToppCellCOVID-19-Heart-EC_3|Heart / Disease (COVID-19 only), tissue and cell type

SAMD5 RALGAPA2 SLC1A1 PREX2 PTPRB VCAM1

4.70e-05190151678e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RALGAPA2 PREX2 ABLIM1 PTPRB GFOD1 VCAM1

4.84e-05191151650601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ToppCellControl-Endothelial-VE_Venous|Control / Disease state, Lineage and Cell class

SAMD5 RALGAPA2 PREX2 ABLIM1 PTPRB VCAM1

4.84e-051911516617546cf4883dedf3323e03a53ba5adec334cf8e
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SAMD5 RALGAPA2 PREX2 ABLIM1 PTPRB VCAM1

5.12e-0519315169ba688b35a9ead5d04691b3f3f15484f02dbbd0d
ToppCellIPF-Endothelial-VE_Venous|IPF / Disease state, Lineage and Cell class

SAMD5 RALGAPA2 PREX2 ABLIM1 PTPRB VCAM1

5.12e-05193151629a655fa80feaabe846c90a28363b037e22d24ae
ToppCellIPF-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

SAMD5 RALGAPA2 PREX2 ABLIM1 PTPRB VCAM1

5.12e-051931516ef66a46e7ab44fcc4005a23416e6da478a4cce37
ToppCellEndothelial-endothelial_cell_of_vein|World / Lineage, Cell type, age group and donor

SAMD5 RALGAPA2 PREX2 PTPRB GFOD1 VCAM1

5.27e-0519415163cbd9622a68e89add90e589867d88c83c5a33476
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SLC1A1 ADCY2 OPRK1 FRY MARVELD3 TBX1

5.27e-051941516b19e16a76d7342ff9a665d19c9151652916f17d4
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Tacstd2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN SAMD5 SERPINA12 OPRM1 GPR161

5.35e-051191515e868453c02dcf0e07821886b81ca739887d43c67
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RYR3 OPRK1 PRKAG3 ABCC12 MYO15A UNC80

5.43e-051951516d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RYR3 OPRK1 PRKAG3 ABCC12 MYO15A UNC80

5.43e-05195151619853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellcellseq-Epithelial-Epithelial_Alveolar-AT1-AT1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TES NEDD4L SLC1A1 ABLIM1 ATP11A PCYOX1

5.58e-0519615166731fef8c148b6681d6ed38afdf23c8213e0bbbe
ToppCellcellseq-Epithelial-Epithelial_Alveolar-AT1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TES NEDD4L SLC1A1 ABLIM1 ATP11A PCYOX1

5.58e-0519615166856317cd0cdcb88fe54b4ae905d91e13495b1c4
ToppCellnucseq-Endothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RELN RALGAPA2 PREX2 ABLIM1 PTPRB TBX1

5.74e-051971516ebf9be068eaa658493fa7884fd19f34642922acb
ToppCellsevere-Plasmablast|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

UBA5 ATP13A1 SEC11C P2RX5 BUB1 SYVN1

5.91e-0519815160b1620ad4352ee5d599a72931aaceab4ca407498
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SAMD5 PREX2 ABLIM1 PTPRB GFOD1 VCAM1

6.07e-0519915163a4deea6e11a0555d27497b7c9983350797aac69
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / Treatment groups by lineage, cell group, cell type

PHYHD1 RALGAPA2 PREX2 ABLIM1 PTPRB VCAM1

6.24e-052001516b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PHYHD1 ADCY2 RYR3 ABLIM1 SLC13A5 ABCC12

6.24e-0520015167a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADCY2 PREX2 RYR3 ABLIM1 SLC13A5 PYGM

6.24e-052001516d0812817ef99608994193787a62d39adeb2070ca
ToppCellwk_08-11-Epithelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

TES NEDD4L SEC11C PTPRZ1 ATP11A MARVELD3

6.24e-052001516445fc7995ffc440c6256a6aab0bbf33fb0fea028
ToppCellMacroglial-Astrocytes-GFAP---|Macroglial / cells hierarchy compared to all cells using T-Statistic

DHRS3 PHYHD1 TENM2 ADCY2 RYR3 ABLIM1

6.24e-05200151688d66550781a3c9102ff7455f5cff6fb072943cd
ToppCellMacroglial-Astrocytes-GFAP-|Macroglial / cells hierarchy compared to all cells using T-Statistic

DHRS3 PHYHD1 TENM2 ADCY2 RYR3 ABLIM1

6.24e-052001516d6a059b0ef763c281c60b1ac76da6079ea822f80
ToppCellMacroglial-Astrocytes-GFAP--|Macroglial / cells hierarchy compared to all cells using T-Statistic

DHRS3 PHYHD1 TENM2 ADCY2 RYR3 ABLIM1

6.24e-05200151616269fa4adb28fc6ed032bbdba8781237dd0d249
ToppCellMacroglial-Astrocytes-GFAP----L1-2|Macroglial / cells hierarchy compared to all cells using T-Statistic

DHRS3 PHYHD1 TENM2 ADCY2 RYR3 ABLIM1

6.24e-052001516c6f43bbbd5df5f2c19ae385f1a6b6a330abede2f
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Bronchial_vessel-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD5 RALGAPA2 PREX2 ABLIM1 PTPRB VCAM1

6.24e-052001516c55efd997392e99068b673542f56f1a209c5a6c8
ToppCellMacroglial-Astrocytes-GFAP|Macroglial / cells hierarchy compared to all cells using T-Statistic

DHRS3 PHYHD1 TENM2 ADCY2 RYR3 ABLIM1

6.24e-05200151679634b1086934412ae92f259ab43554ce545008f
ToppCellParenchyma_COVID-19-Endothelial-TX-Bronchial_vessel|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

SAMD5 RALGAPA2 PREX2 ABLIM1 PTPRB VCAM1

6.24e-052001516a18817d36b2b30a32e1513d36174bf98dfea2a92
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADCY2 PREX2 RYR3 ABLIM1 SLC13A5 PYGM

6.24e-052001516cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Bronchial_vessel|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

SAMD5 RALGAPA2 PREX2 ABLIM1 PTPRB VCAM1

6.24e-05200151671979bbcc035d5b8882f1502b5a8ef248aaba45a
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN SAMD5 SERPINA12 OPRM1 GPR161

6.76e-051251515d05556ea185c15815a4f8643f1c01185badbeece
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Myh4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN SAMD5 SERPINA12 OPRM1 GPR161

7.85e-051291515f83187c0bb06528127b8d2d56674ab1946846951
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Tfh|GI_small-bowel / Manually curated celltypes from each tissue

GPR161 DNAH12 SLC10A1 CACNA1I UTY

9.39e-051341515bf94ce5edde8912a27010e229c313d8102d6de62
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O2-Tfr|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SEC11C PRKAG3 SERPINB2 CLRN2

9.41e-05701514125f8e8fcd14420dff5b18f2270516d5baafd38e
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-T-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THNSL1 MALRD1 PTPRZ1 ANAPC2 PYGM

1.01e-041361515186be8e1595608004b8216892cb9c7a7f31fbb4d
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Tacstd2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN TES SAMD5 OPRD1 OPRM1

1.27e-04143151524fd24846fbef049af669a57d42fcc18928d2b27
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN ADCY2 OPRK1 OPRM1 GPR161

1.32e-04144151571107275767a0728541a3695715c44874b3e5efc
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SERPINA12 RYR3 CHRNB4 THBS3 PTPRZ1

1.36e-041451515590ba937c741ae67460f303eca88b1cd3ac87f64
DrugNSC117862

CYP2E1 CYP3A4 CYP4A11 OPRD1 OPRK1 OPRM1

4.17e-08301526CID000003648
DrugDextrorphan

CYP3A4 OPRD1 OPRK1 OPRM1

6.58e-0871524ctd:D003917
DrugAC1L1ILY

CYP2E1 CYP3A4 CYP4A11 OPRD1 OPRK1 OPRM1

1.86e-07381526CID000004635
DrugTRK 820

OPRD1 OPRK1 OPRM1

2.92e-0731523ctd:C111212
DrugOxycodone

OPRD1 OPRK1 OPRM1

2.92e-0731523DB00497
DrugHydromorphone

OPRD1 OPRK1 OPRM1

2.92e-0731523DB00327
DrugCodeine

OPRD1 OPRK1 OPRM1

2.92e-0731523DB00318
DrugCarfentanil

OPRD1 OPRK1 OPRM1

2.92e-0731523DB01535
DrugMorphine

OPRD1 OPRK1 OPRM1

2.92e-0731523DB00295
DrugHydrocodone

OPRD1 OPRK1 OPRM1

2.92e-0731523ctd:D006853
Drug3-Methylfentanyl

OPRD1 OPRK1 OPRM1

2.92e-0731523DB01571
DrugHeroin

OPRD1 OPRK1 OPRM1

2.92e-0731523DB01452
Drug3-Methylthiofentanyl

OPRD1 OPRK1 OPRM1

2.92e-0731523DB01439
Drugmorphine-7,8-oxide

OPRD1 OPRK1 OPRM1

2.92e-0731523CID005491901
DrugLevorphanol

OPRD1 OPRK1 OPRM1

2.92e-0731523ctd:D007981
DrugLevallorphan

OPRD1 OPRK1 OPRM1

2.92e-0731523ctd:D007977
DrugBuprenorphine

OPRD1 OPRK1 OPRM1

2.92e-0731523DB00921
DrugLevorphanol

OPRD1 OPRK1 OPRM1

2.92e-0731523DB00854
DrugRemifentanil

OPRD1 OPRK1 OPRM1

2.92e-0731523DB00899
DrugNalbuphine

OPRD1 OPRK1 OPRM1

2.92e-0731523DB00844
DrugFentanyl

OPRD1 OPRK1 OPRM1

2.92e-0731523DB00813
DrugSufentanil

OPRD1 OPRK1 OPRM1

2.92e-0731523DB00708
DrugPropoxyphene

OPRD1 OPRK1 OPRM1

2.92e-0731523DB00647
DrugButorphanol

OPRD1 OPRK1 OPRM1

2.92e-0731523DB00611
DrugButorphanol

OPRD1 OPRK1 OPRM1

2.92e-0731523ctd:D002077
Drugcyclorphan

OPRD1 OPRK1 OPRM1

2.92e-0731523ctd:C084603
DrugAlvimopan

OPRD1 OPRK1 OPRM1

2.92e-0731523DB06274
Drugdextrallorphan

OPRD1 OPRK1 OPRM1

2.92e-0731523ctd:C044130
Drug14-phenylpropoxymetopon

OPRD1 OPRK1 OPRM1

2.92e-0731523ctd:C478565
Drugbuprenorphine hydrochloride solution

CYP3A4 OPRD1 OPRK1 OPRM1 UGT1A3 FEN1

2.97e-07411526CID000002476
DrugAC1L1IMA

CYP2E1 CYP3A4 CYP4A11 OPRD1 OPRK1 OPRM1

2.97e-07411526CID000004639
Drugpropoxyphene

CYP2E1 CYP3A4 CYP4A11 OPRD1 CYP4A22 OPRK1 OPRM1

3.20e-07671527CID000010100
DrugAC1L2K1Q

CYP2E1 CYP3A4 CYP4A11 OPRD1 OPRK1

3.79e-07231525CID000022258
DrugCodeine

CYP3A4 OPRD1 OPRK1 OPRM1

3.89e-07101524ctd:D003061
DrugAC1LCF1O

CYP3A4 OPRD1 OPRK1 OPRM1

3.89e-07101524CID000627285
Drugcyclamate

OPRD1 OPRK1 OPRM1 CLCN6 TAS1R2

1.08e-06281525CID000007533
DrugDynorphins

OPRD1 OPRK1 OPRM1

1.16e-0641523ctd:D004399
DrugAC1L5BQM

OPRD1 OPRK1 OPRM1

1.16e-0641523CID000174892
DrugDiprenorphine

OPRD1 OPRK1 OPRM1

1.16e-0641523DB01548
Drug3B-b

OPRD1 OPRK1 OPRM1

1.16e-0641523CID000533975
DrugNaltrexone

OPRD1 OPRK1 OPRM1

1.16e-0641523DB00704
DrugMethadyl Acetate

OPRD1 OPRK1 OPRM1

1.16e-0641523ctd:D008692
Drug7-hydroxymitragynine

OPRD1 OPRK1 OPRM1

1.16e-0641523ctd:C482678
Drugmethadol

CYP3A4 OPRD1 OPRK1 OPRM1

1.30e-06131524CID000028397
Drugcyprodime hydrobromide

OPRD1 OPRK1 OPRM1 MUC5AC

1.30e-06131524CID005748293
Drugnaltrindole-5'-isothiocyanate

TES OPRD1 OPRK1 OPRM1

1.81e-06141524CID005487327
DrugI06-1317

OPRD1 OPRK1 OPRM1 TAS1R2

1.81e-06141524CID003081923
Drugmitragynine

CYP3A4 OPRD1 OPRK1 OPRM1

2.46e-06151524ctd:C001801
Drugnorbuprenorphine

CYP2E1 CYP3A4 OPRM1 UGT1A3 NEO1

2.53e-06331525CID000114976
DrugDihydromorphine

OPRD1 OPRK1 OPRM1

2.89e-0651523DB01565
DrugNaloxone

OPRD1 OPRK1 OPRM1

2.89e-0651523DB01183
Drugoxymorphamine

OPRD1 OPRK1 OPRM1

2.89e-0651523CID000134844
DrugSc 39566

OPRD1 OPRK1 OPRM1

2.89e-0651523CID000130018
DrugDextromethorphan

CYP2E1 CYP3A4 OPRD1 OPRK1 OPRM1

2.95e-06341525ctd:D003915
Druglevo-dromoran tartrate

CYP2E1 CYP3A4 ADCY2 OPRD1 OPRK1 OPRM1 UGT1A3

4.28e-06981527CID000003918
DrugBuprenorphine

CYP3A4 OPRD1 OPRK1 OPRM1

5.43e-06181524ctd:D002047
DrugAC1L1QMT

CYP2E1 CYP3A4 OPRD1 OPRK1

5.43e-06181524CID000008270
DrugEtorphine

OPRD1 OPRK1 OPRM1

5.75e-0661523DB01497
DrugAC1L2OET

OPRD1 OPRK1 OPRM1

5.75e-0661523CID000125331
DrugNSC612111

OPRD1 OPRK1 OPRM1

5.75e-0661523CID000163346
DrugLoperamide

OPRD1 OPRK1 OPRM1

5.75e-0661523DB00836
DrugRX8008M

OPRD1 OPRK1 OPRM1

5.75e-0661523CID000162443
Drugloperamide

CACNA1S CYP3A4 RYR3 OPRD1 OPRK1 OPRM1 CACNA1I

6.78e-061051527CID000003954
DrugNeomycin sulfate [1405-10-3]; Up 200; 4.2uM; HL60; HG-U133A

UBA5 MED18 TES SPG7 YJU2 CLCN6 P2RX5 ANAPC2 DDX28

7.94e-0619915291383_UP
DrugNSC76436

CYP3A4 OPRD1 OPRK1 OPRM1

8.51e-06201524CID000002828
Drug2',6'-dimethyltyrosine

OPRD1 OPRK1 OPRM1 SLC15A1

8.51e-06201524CID000124247
Drugfentanyl

CACNA1S CYP3A4 RYR3 OPRD1 OPRK1 OPRM1 PYGM

9.78e-061111527CID000003345
DrugTyr-ala-phe-gly

OPRD1 OPRK1 OPRM1

1.00e-0571523CID005487532
DrugEnkephalin, D-Penicillamine (2,5)-

OPRD1 OPRK1 OPRM1

1.00e-0571523ctd:D020881
DrugMET-CAMO

OPRD1 OPRK1 OPRM1

1.00e-0571523CID006450159
Drugphenylmorphan

OPRD1 OPRK1 OPRM1

1.00e-0571523CID000146306
DrugAC1L9PCU

OPRD1 OPRK1 OPRM1

1.00e-0571523CID000451042
DrugN-cyclopropylmethylnorazidomorphine

OPRD1 OPRK1 OPRM1

1.00e-0571523CID005489191
Drug2-mercaptoacetate

OPRD1 OPRK1 OPRM1

1.00e-0571523ctd:C017487
DrugDextropropoxyphene

OPRD1 OPRK1 OPRM1

1.00e-0571523ctd:D011431
DrugAC1L2YDY

OPRD1 OPRK1 LHCGR

1.00e-0571523CID000130992
Drugbeta-naltrexamine

OPRD1 OPRK1 OPRM1

1.00e-0571523CID005486948
DrugNDTMB

OPRD1 OPRK1 OPRM1

1.00e-0571523CID000134748
Drugethosuximide

CACNA1S CYP2E1 CYP3A4 CHRNA1 RYR3 CACNA1I

1.02e-05741526CID000003291
Drugdulcin

OPRD1 OPRK1 OPRM1 UGT1A3

1.05e-05211524CID000009013
Drugacetylmethadol

CYP3A4 OPRD1 OPRK1 OPRM1

1.05e-05211524CID000010517
DrugNSC35549

CYP3A4 OPRD1 OPRK1 OPRM1

1.27e-05221524CID000411697
Drugbeta-CNA

ADCY2 OPRD1 OPRK1 OPRM1

1.53e-05231524CID005486190
DrugICI 204448

OPRD1 OPRK1 OPRM1

1.59e-0581523CID000003683
Drugmetazocine

OPRD1 OPRK1 OPRM1

1.59e-0581523CID000062518
DrugAC1L1B1Q

OPRD1 OPRK1 OPRM1

1.59e-0581523CID000001246
DrugDIPPA

OPRD1 OPRK1 OPRM1

1.59e-0581523CID000127914
DrugTyr-D-Ala-Gly-Phe-Leu-chloromethyl ketone

OPRD1 OPRK1 OPRM1

1.59e-0581523CID005492572
DrugU 69593

OPRD1 OPRK1 OPRM1

1.59e-0581523ctd:C045444
DrugAC1L2Y8M

TES OPRD1 OPRK1

1.59e-0581523CID000130908
Drug14-methoxymetopon

OPRD1 OPRK1 OPRM1

1.59e-0581523CID005486940
DrugKT-89

OPRD1 OPRK1 OPRM1

1.59e-0581523CID005748450
Drugbinaltorphimine

OPRD1 OPRK1 OPRM1

1.59e-0581523CID005484197
DrugN-methyl nalorphine

OPRD1 OPRK1 OPRM1

1.59e-0581523CID005748235
DrugAC1LBBLW

OPRD1 OPRK1 OPRM1

1.59e-0581523CID000579851
DrugOxymorphone hydrazone

OPRD1 OPRK1 OPRM1

1.59e-0581523CID009577748
Druggamma-aminobutyric acid

CACNA1S RELN SPG7 SLC1A1 CHRNA1 RYR3 OPRD1 OPRK1 OPRM1 NEO1 CLCN6 CACNA1I ACP4

1.86e-0547415213CID000000119
DrugTramadol

CYP3A4 OPRD1 OPRK1 OPRM1

2.17e-05251524ctd:D014147
Drugpimozide

CACNA1S CYP3A4 RYR3 OPRD1 OPRK1 OPRM1 CACNA1I

2.35e-051271527CID000016362
DrugDam K

OPRD1 OPRK1 OPRM1

2.38e-0591523CID005487344
Diseasesevere acute respiratory syndrome, COVID-19

RELN ANXA4 SAMD5 TENM2 PREX2 NLN PTPN4 ABLIM1 MALRD1 SLC15A1 ATP11A

1.31e-0544714411EFO_0000694, MONDO_0100096
DiseaseKabuki syndrome (implicated_via_orthology)

KDM6A UTY

7.07e-0531442DOID:0060473 (implicated_via_orthology)
DiseaseHypotension, Orthostatic

OPRD1 OPRM1

7.07e-0531442C0020651
Diseaselevel of Sphingomyelin (d34:1) in blood serum

ADAMTS3 USP24 SMARCA4

8.80e-05181443OBA_2045175
DiseaseGeneralized seizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0234533
DiseaseClonic Seizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0234535
DiseaseConvulsive Seizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0751494
DiseaseSeizures, Sensory

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0751496
DiseaseNon-epileptic convulsion

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0751056
DiseaseAtonic Absence Seizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0751123
DiseaseComplex partial seizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0149958
DiseaseSingle Seizure

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0751110
DiseaseNonepileptic Seizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C3495874
DiseaseVisual seizure

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0270824
DiseaseEpileptic drop attack

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0270846
DiseaseVertiginous seizure

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0422855
DiseaseGustatory seizure

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0422854
DiseaseSeizures, Somatosensory

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0422850
DiseaseOlfactory seizure

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0422853
DiseaseSeizures, Auditory

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0422852
DiseaseGeneralized Absence Seizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C4505436
DiseaseJacksonian Seizure

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C0022333
DiseaseEpileptic Seizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.40e-041011445C4317109
Diseaseunipolar depression, smoking behaviour measurement

OR5AK2 OR5AK3P

1.41e-0441442EFO_0003761, EFO_0005671
DiseaseAbsence Seizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.47e-041021445C4316903
DiseaseConvulsions

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.47e-041021445C4048158
DiseaseTonic Seizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.47e-041021445C0270844
DiseaseSeizures, Focal

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.61e-041041445C0751495
DiseaseMyoclonic Seizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.61e-041041445C4317123
DiseaseTonic - clonic seizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2

1.61e-041041445C0494475
DiseaseDrug habituation

TENM2 OPRD1 OPRM1 ABLIM1 TTC21B

2.58e-041151445C0013170
DiseaseDrug abuse

TENM2 OPRD1 OPRM1 ABLIM1 TTC21B

2.58e-041151445C0013146
DiseasePrescription Drug Abuse

TENM2 OPRD1 OPRM1 ABLIM1 TTC21B

2.58e-041151445C4316881
DiseaseSubstance-Related Disorders

TENM2 OPRD1 OPRM1 ABLIM1 TTC21B

2.58e-041151445C0236969
DiseaseDrug Use Disorders

TENM2 OPRD1 OPRM1 ABLIM1 TTC21B

2.58e-041151445C0013222
DiseaseDrug Dependence

TENM2 OPRD1 OPRM1 ABLIM1 TTC21B

2.58e-041151445C1510472
DiseaseSubstance Dependence

TENM2 OPRD1 OPRM1 ABLIM1 TTC21B

2.58e-041151445C0038580
DiseaseSubstance Use Disorders

TENM2 OPRD1 OPRM1 ABLIM1 TTC21B

2.58e-041151445C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

TENM2 OPRD1 OPRM1 ABLIM1 TTC21B

2.58e-041151445C0029231
DiseaseSubstance abuse problem

TENM2 OPRD1 OPRM1 ABLIM1 TTC21B

2.68e-041161445C0740858
Diseaseoral cavity cancer (is_implicated_in)

CYP2E1 CHRNB4

3.50e-0461442DOID:8618 (is_implicated_in)
DiseaseX-14939 measurement

CYP4A11 CYP4A22

3.50e-0461442EFO_0800747
Diseasealpha 1-antitrypsin deficiency (implicated_via_orthology)

SERPINA12 SYVN1

4.89e-0471442DOID:13372 (implicated_via_orthology)
DiseaseX-18899 measurement

UBA5 CYP4A11

4.89e-0471442EFO_0800793
DiseaseCocaine Dependence

CHRNB4 OPRD1 OPRK1 OPRM1 SMARCA4

6.15e-041391445C0600427
DiseaseEpilepsy, Cryptogenic

SLC1A1 OPRD1 OPRM1 KCNQ2

7.08e-04821444C0086237
DiseaseAwakening Epilepsy

SLC1A1 OPRD1 OPRM1 KCNQ2

7.08e-04821444C0751111
DiseaseAura

SLC1A1 OPRD1 OPRM1 KCNQ2

7.08e-04821444C0236018
DiseaseSeizures

SLC1A1 CHRNB4 OPRK1 OPRM1 KCNQ2 EIF3F

7.26e-042181446C0036572
Diseaselung adenocarcinoma (is_marker_for)

CHRNB4 PTPRB ERGIC3 ANAPC2

8.11e-04851444DOID:3910 (is_marker_for)
DiseaseAutism Spectrum Disorders

RELN SLC1A1 IQGAP3 UNC80

8.11e-04851444C1510586
Diseasecystic fibrosis (implicated_via_orthology)

ABCC12 EDEM1

8.33e-0491442DOID:1485 (implicated_via_orthology)
Diseasecolorectal cancer, hormone replacement therapy

SAMD5 SEC11C OPRK1 SLC15A1

9.23e-04881444EFO_0003961, MONDO_0005575
DiseaseCongenital myasthenic syndrome

MYO9A CHRNA1

1.04e-03101442cv:C0751882
Diseaseasthma exacerbation measurement

RMDN2 TENM2 MALRD1 VCAM1

1.13e-03931444EFO_0007614
Diseaseautosomal recessive polycystic kidney disease (biomarker_via_orthology)

CYP4A11 CYP4A22

1.26e-03111442DOID:0110861 (biomarker_via_orthology)
DiseaseRespiratory Depression

CACNA1S OPRM1

1.78e-03131442C0235063
DiseaseRespiratory Insufficiency

CACNA1S OPRM1

1.78e-03131442C0035229
DiseaseRespiratory Failure

CACNA1S OPRM1

1.78e-03131442C1145670
Diseaseeosinophil measurement

MED18 FAM133B SMARCA4 GFM1

1.97e-031081444EFO_0803540
DiseaseEpilepsy

SLC1A1 OPRD1 OPRM1 KCNQ2

2.04e-031091444C0014544
Diseaseesterified cholesterol measurement, low density lipoprotein cholesterol measurement

ADAMTS3 SMARCA4

2.07e-03141442EFO_0004611, EFO_0008589
DiseaseHepatitis C

CYP3A4 OPRM1

2.38e-03151442C0019196
Diseasealcohol use disorder (implicated_via_orthology)

CHRNA1 RYR3 SMARCA4 KDM6A UTY

2.75e-031951445DOID:1574 (implicated_via_orthology)
DiseaseWithdrawal Symptoms

CHRNB4 OPRD1 OPRK1

2.89e-03581443C0087169
DiseaseDrug Withdrawal Symptoms

CHRNB4 OPRD1 OPRK1

2.89e-03581443C0086189
DiseaseSubstance Withdrawal Syndrome

CHRNB4 OPRD1 OPRK1

2.89e-03581443C0038587
Diseaseparental longevity

ADAMTS3 ATP13A1 SLC1A1 SNX29 RYR3 CHRNB4 SMARCA4 PHLPP1

3.02e-034941448EFO_0007796
DiseaseGlycogen storage disease

PHKB PYGM

3.07e-03171442cv:C0017919
Diseaseesophageal carcinoma, gastric carcinoma

SAMD5 RMDN2

3.07e-03171442EFO_0000178, EFO_0002916
Diseaseangiopoietin-related protein 1 measurement

ANGPTL1 UGT1A3

3.44e-03181442EFO_0801382
Diseasefamilial hyperlipidemia (biomarker_via_orthology)

CYP2E1 VCAM1

3.83e-03191442DOID:1168 (biomarker_via_orthology)
Diseasefatty acid measurement, linoleic acid measurement

PRKAG3 FEN1 SMARCA4

4.52e-03681443EFO_0005110, EFO_0006807
Diseaselung non-small cell carcinoma (is_implicated_in)

CHRNB4 PTPRB SMARCA4 KDM6A

4.87e-031391444DOID:3908 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
TFMQRVKNMLYPLAL

UGT1A3

206

P35503
LGMATAYMILKQTPR

TTC21B

1161

Q7Z4L5
DVPLIGKYLMFTMVL

CHRNB4

291

P30926
SGPNSRLYMKLVMRI

ESYT1

581

Q9BSJ8
VYMKGAPEMVARFCR

ATP13A5

621

Q4VNC0
DRIYNMLRMFVVTGP

ANAPC2

771

Q9UJX6
FYIGTQLMERLKPSM

BUB1

831

O43683
FPYEMLMVTNRGRNK

ABLIM1

716

O14639
LRKPGAQIYMRFMQE

PRKAG3

176

Q9UGI9
IRKMGNKPHMIQVYR

ATP13A1

291

Q9HD20
KPYVGLMADSVRVML

CYP4A11

156

Q02928
GSYSLRAVQMMIKPI

ANGPTL1

476

O95841
VMIVLAFIILNYGPM

ATF6

381

P18850
FEQVIVGMMTPTVLY

ANXA4

76

P09525
PVFTLYVGSQRMVVM

CYP2E1

66

P05181
VMSGGILIYKNRVRM

PTPN4

236

P29074
VPLIGKYMLFTMVFV

CHRNA1

291

P02708
DKMASVFYTVIIPML

OR8U8

271

P0C7N1
IRVTVIPFYMGMREA

POLDIP2

241

Q9Y2S7
VSYIPFHVMKTMNLR

P2RY1

271

P47900
FQNLLQGRMYKMVIV

PTPRB

1141

P23467
VKMMYLGVGVFSLPL

OR1A2

196

Q9Y585
NYPVIMNRGVFMKLV

OR10A3

131

P58181
GLPVMFMATTKYRQG

OPRM1

201

P35372
DKAVAVFYTMVVPML

OR4C12

266

Q96R67
MGKRDNRVAYMNPIA

FAM133A

1

Q8N9E0
LIAMLPLVGVSNYMK

LHCGR

496

P22888
NGMVGLVPKNYVTVM

NCK1

236

P16333
VESMKYPFRQGMRLE

L3MBTL2

316

Q969R5
KVMPNMYRVGVSKLF

MYO15A

1871

Q9UKN7
ILGMNTVQLYMKVPG

KDM6A

1126

O15550
MFIPKGVVVMIPSYA

CYP3A4

386

P08684
KFLNEMIAPVMRVNY

PCYOX1

211

Q9UHG3
KLDFLVNIYMQRMGI

KCNQ2

636

O43526
MVVVMNFPYCGLRKV

OR2V2

161

Q96R30
PKMEMILSGVVAIFY

OR2W1

21

Q9Y3N9
VLNPVIYTFRNKEMM

OR4F6

281

Q8NGB9
DKMVAVFYTIITPML

OR4S2

266

Q8NH73
VFVLYELSPMMVKLT

ERGIC3

321

Q9Y282
MPALMRVGIFQSFQK

DDX28

431

Q9NUL7
VLFRTVAMMVPNYAL

DNAH12

1371

Q6ZR08
KLMGVVPVSYFIRNM

LRRC74A

91

Q0VAA2
VKMYATIPELGVQVM

MUC5AC

5026

P98088
VYQVAKMINLMRPGV

PTPRZ1

2251

P23471
LMYLCVTVPKMLVGQ

OR2T34

76

Q8NGX1
LMYLCVTVPKMLVGQ

OR2T3

76

Q8NH03
EKVVSMFYTLGIPML

OR5J2

271

Q8NH18
IIYPMKNHMFFIAIT

RALGAPA2

1771

Q2PPJ7
DKMASVFYTVIIPML

OR8U9

271

P0C7N5
MVAVAKPMVYITVGE

IQGAP3

1271

Q86VI3
ELIIQPGYMMQFKIV

RELN

3111

P78509
MKIMVYKIFRILVPG

MED18

141

Q9BUE0
MKVASIFYGTVIPML

OR5AK3P

271

Q8NH89
GNVLVMFGIVRYTKM

OPRD1

66

P41143
LPVMYLMDSIVKNVG

PCF11

71

O94913
PQYMRYVIKGGMIII

SLC10A1

181

Q14973
SRVQRLGLPLKMVMY

ACP4

271

Q9BZG2
MKVAFIFYGTVIPML

OR5AK2

271

Q8NH90
MIDPRSMGILKVYTI

MALRD1

1816

Q5VYJ5
VVYTMLPFNMRDAII

ADCY2

146

Q08462
INVVLVRMIMLGYAK

ADAMTS3

301

O15072
ITYGLPIMVTLMVAK

CLCN6

551

P51797
TIRMMENGIKPVYVF

FEN1

71

P39748
MGKRDNRVAYMNPIA

FAM133B

1

Q5BKY9
YLMSGVMAPVKRRNV

GBA2

576

Q9HCG7
RTMGVMFTPLTVKYA

EIF3F

226

O00303
YAVIGMQMFGKIALV

CACNA1S

1281

Q13698
IVDSKYFNRGIMMAI

CACNA1I

636

Q9P0X4
KPYVGLMADSVRVML

CYP4A22

156

Q5TCH4
KPYVAMVTTYQMAVL

CUL2

571

Q13617
PLKSIYMRQIDQMVG

EDEM1

641

Q92611
QFYQLKLPMVTVAMA

MARVELD3

261

Q96A59
VMRLVKGMNFSVVVF

GET3

151

O43681
PMKITGNRAVMALVY

GPR161

136

Q8N6U8
PFAYCMMIRVASKQL

COPG1

226

Q9Y678
PYVVQSIISLIMGMK

FRY

261

Q5TBA9
QMKAFPRIVRESYAM

CCDC168

6561

Q8NDH2
FRYKLLRAGGVMVMP

MLLT1

131

Q03111
MTVNRQMKRYNVPFL

GFM1

156

Q96RP9
MPAKFVRCAYVIILM

SLC13A5

31

Q86YT5
QIKMVTRVMFLYIPL

SLC15A1

276

P46059
FIVVRKNPFRFAMGM

SLC1A1

306

P43005
GLQMPVVVQSMYIFK

PHYHD1

131

Q5SRE7
MFPLQMIYLVVKAAV

DHRS3

11

O75911
YMMIDGVFRGNPKQV

PHKB

371

Q93100
PVQMMYLREKLNIGY

SERPINB2

231

P05120
TLMKAYGIRFDVMVN

P2RX5

311

Q93086
VKMMYLGVGIFSVPL

OR1A1

196

Q9P1Q5
FRPLSMYSVMKGRVA

OR1L4

261

Q8NGR5
GNSLVMFVIIRYTKM

OPRK1

76

P41145
RYPVIMSKGAYVAMA

OR13C8

131

Q8NGS7
HYKRILTPQVMLGMS

OR52I2

161

Q8NH67
YVMIFRAVMGLATPE

OR52M1

221

Q8NGK5
QDMMSYIGPKRTAVV

PIGS

156

Q96S52
DKMASVFYTVIIPML

OR8U1

271

Q8NH10
RPMYLAMRQFKKAVT

SYVN1

246

Q86TM6
YMVRIISKAPCMVLR

SZT2

651

Q5T011
MNTVQLYMKVPGSRT

UTY

1076

O14607
LVPGKYVMVMGVVQA

RMI2

96

Q96E14
PAIGMIIYFARKANM

VCAM1

711

P19320
SDGIPMYKRNVMILT

TES

81

Q9UGI8
MYKRNVMILTNPVAA

TES

86

Q9UGI8
AFVEGVKMRTYKPLM

PUS3

401

Q9BZE2
VGMVTIIMNDYPKFK

SEC11C

161

Q9BY50
YLRSVMNKVIQMVPE

SNX29

741

Q8TEQ0
PVIFLVQASGMNVYM

SFXN4

201

Q6P4A7
SRKVPMAGILEYLMN

SAMD5

151

Q5TGI4
YPKLMSIMGNVLRFL

GFOD1

111

Q9NXC2
PYLRGTIKMMQAVRQ

GFOD1

301

Q9NXC2
FCGILYMKPRMKIFL

MORC4

271

Q8TE76
QNLMPATVYIFRVMA

NEO1

501

Q92859
RAQIMAYKMLARGQP

SMARCA4

181

P51532
LMTKTYIPILAFTQM

TMEM69

116

Q5SWH9
MPYSTNKELILGIMV

RMDN2

1

Q96LZ7
NGLMYFVDATMIRKV

TENM2

1366

Q9NT68
KMVAVFYTTVIPMLN

OR5M8

271

Q8NGP6
IAGMITVAYPQMKLK

PEX11A

231

O75192
VVFGRPRLALMYRMQ

SPG7

201

Q9UQ90
DKMASVFYTVVIPML

OR8U3

271

Q8NH85
GISVYVIFIPVQMFM

ABCC12

266

Q96J65
MIVCVDKRLQSPMYF

OR9A4

46

Q8NGU2
IKRAQIMGFMPVTYK

MRPS18C

111

Q9Y3D5
VKMMTQKGLYRIGFI

SERPINB12

221

Q96P63
VKVPMMFRSGIYQVG

SERPINA12

236

Q8IW75
QDVARMMYVVFKEVP

B3GALT9

251

A8MXE2
LFAFVIKMPVMYRIG

CLPTM1

556

O96005
MGFAILNMIQVPYRA

CLRN2

116

A0PK11
PVSMYVTVEMQKFLG

ATP11A

361

P98196
IMNPEVGMKYRNLIL

NLN

656

Q9BYT8
IEPTMVVQGVKMLYV

UBA6

981

A0AVT1
PHLMSIFKGRMVVYQ

VIL1

486

P09327
GMLKYIRLQVMSLSP

UNC80

1556

Q8N2C7
APGYHMAKMIIRLVT

PYGM

611

P11217
KVFYQHPNLMRVLGM

RYR3

2051

Q15413
NPYSRLMALKRMGIV

UBA5

51

Q9GZZ9
FKEMMRFIYTGRAPN

SPOPL

251

Q6IQ16
RNPYLVAKLVEVMFM

UBE4B

926

O95155
AAVYAKMMGIPIRKF

THNSL1

516

Q8IYQ7
PRYIMQATDVMRKQG

PREX2

1556

Q70Z35
YVVRLMAPFNMRCKT

YJU2

31

Q9BW85
AYLRMQGFVESMKII

THBS3

176

P49746
QGPYVSMAFITVLKM

TAS1R2

676

Q8TE23
YMILYITGRPDMQKQ

PITPNM3

776

Q9BZ71
MPVRYFIMKSSNLRN

YTHDC2

1286

Q9H6S0
GLFVEKMPARIYQMV

USP24

2106

Q9UPU5
EYMVNTFIVMQRKLG

PHLPP1

1241

O60346
MRGLYRGIAPNFMKV

SLC25A23

431

Q9BV35
FKGSQGYLVVRLSMM

SUN1

671

O94901
EMIITKAGRRMFPSY

TBX4

86

P57082
GRRMFPTFQVKLFGM

TBX1

136

O43435
SPGMVLMQRAKLYLE

VRTN

396

Q9H8Y1
YARYLKMVQVGVPVM

WASHC3

136

Q9Y3C0
TAQTFIYPMEVMKTR

SLC25A24

301

Q6NUK1
PFTGYIIAVHRKMMR

USP32

1071

Q8NFA0
MEMVGFLPKTRRQIF

MYO9A

406

B2RTY4
FIRPFYKMMLGKQIT

NEDD4L

731

Q96PU5