Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	snRNA methyltransferase activity	METTL4 METTL16	5.24e-05	2	145	2	GO:0106346
GeneOntologyMolecularFunction	neurexin family protein binding	NLGN4Y NLGN1 NLGN4X	1.96e-04	16	145	3	GO:0042043
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	DDX31 POLE SPO11 DARS1 ZNFX1 MSH3 METTL4 ERN2 TERT NSUN2 GGT5 ANGEL2 METTL16 GEN1	2.60e-04	645	145	14	GO:0140640
GeneOntologyMolecularFunction	ubiquitin-like protein-specific endopeptidase activity	SENP6 SENP7	5.16e-04	5	145	2	GO:0070137
GeneOntologyMolecularFunction	SUMO-specific endopeptidase activity	SENP6 SENP7	5.16e-04	5	145	2	GO:0070139
GeneOntologyMolecularFunction	ATP-dependent activity	DDX31 ABCA12 RNF213 SPO11 NLRP1 ZNFX1 MSH3 DNAH12 ABCC8 MYO3B KIF19 UBA6 MACF1	5.48e-04	614	145	13	GO:0140657
GeneOntologyMolecularFunction	DNA insertion or deletion binding	XPC MSH3	7.71e-04	6	145	2	GO:0032135
GeneOntologyMolecularFunction	WD40-repeat domain binding	DDB1 CDC5L	7.71e-04	6	145	2	GO:0071987
GeneOntologyCellularComponent	asymmetric, glutamatergic, excitatory synapse	NLGN4Y NLGN1 SEMA3A NLGN4X	2.06e-05	24	144	4	GO:0098985
GeneOntologyCellularComponent	RNA-directed RNA polymerase complex	ZNFX1 TERT	1.41e-04	3	144	2	GO:0031379
GeneOntologyCellularComponent	chromatoid body	NSUN2 TDRD7 TDRD6	2.03e-04	17	144	3	GO:0033391
GeneOntologyCellularComponent	symmetric, GABA-ergic, inhibitory synapse	NLGN4Y NLGN4X	2.80e-04	4	144	2	GO:0098983
GeneOntologyCellularComponent	filopodium tip	NLGN1 ABI2 MYO3B	3.35e-04	20	144	3	GO:0032433
HumanPheno	Early chronotype	PER3 PER2 TIMELESS	4.73e-06	4	55	3	HP:0031873
Domain	Nlgn	NLGN4Y NLGN1 NLGN4X	4.35e-06	5	143	3	IPR000460
Domain	-	SEH1L DMXL2 WDR64 NEDD1 DDB1 WDR59 SEMA3A SEMA6D EML5 CIAO1 BRWD1	5.23e-05	333	143	11	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SEH1L DMXL2 WDR64 NEDD1 DDB1 WDR59 SEMA3A SEMA6D EML5 CIAO1 BRWD1	5.52e-05	335	143	11	IPR015943
Domain	NLGN4	NLGN4Y NLGN4X	5.82e-05	2	143	2	IPR030025
Domain	WD40_repeat_dom	KNTC1 SEH1L DMXL2 WDR64 NEDD1 DDB1 WDR59 EML5 CIAO1 BRWD1	9.87e-05	297	143	10	IPR017986
Domain	SPEC	AKAP6 SYNE1 MACF1 DMD	1.00e-04	32	143	4	SM00150
Domain	Spectrin/alpha-actinin	AKAP6 SYNE1 MACF1 DMD	1.00e-04	32	143	4	IPR018159
Domain	Carboxylesterase_B_CS	NLGN4Y NLGN1 NLGN4X	1.19e-04	13	143	3	IPR019819
Domain	CARBOXYLESTERASE_B_2	NLGN4Y NLGN1 NLGN4X	1.50e-04	14	143	3	PS00941
Domain	COesterase	NLGN4Y NLGN1 NLGN4X	1.50e-04	14	143	3	PF00135
Domain	CarbesteraseB	NLGN4Y NLGN1 NLGN4X	1.50e-04	14	143	3	IPR002018
Domain	Period_circadian-like_C	PER3 PER2	1.74e-04	3	143	2	IPR022728
Domain	Period_C	PER3 PER2	1.74e-04	3	143	2	PF12114
Domain	Spectrin	SYNE1 MACF1 DMD	6.96e-04	23	143	3	PF00435
Domain	ACTININ_2	SYNE1 MACF1 DMD	6.96e-04	23	143	3	PS00020
Domain	ACTININ_1	SYNE1 MACF1 DMD	6.96e-04	23	143	3	PS00019
Domain	Actinin_actin-bd_CS	SYNE1 MACF1 DMD	6.96e-04	23	143	3	IPR001589
Domain	WD40	SEH1L DMXL2 WDR64 NEDD1 WDR59 EML5 CIAO1 BRWD1	8.72e-04	259	143	8	PF00400
Domain	-	INPPL1 EEPD1 ANGEL2	1.00e-03	26	143	3	3.60.10.10
Domain	Exo_endo_phos	INPPL1 EEPD1 ANGEL2	1.00e-03	26	143	3	PF03372
Domain	WD40	SEH1L DMXL2 WDR64 NEDD1 WDR59 EML5 CIAO1 BRWD1	1.09e-03	268	143	8	SM00320
Domain	Endo/exonuclease/phosphatase	INPPL1 EEPD1 ANGEL2	1.12e-03	27	143	3	IPR005135
Domain	Peptidase_C48_C	SENP6 SENP7	1.19e-03	7	143	2	IPR003653
Domain	Peptidase_C48	SENP6 SENP7	1.19e-03	7	143	2	PF02902
Domain	ULP_PROTEASE	SENP6 SENP7	1.19e-03	7	143	2	PS50600
Domain	WD40_repeat	SEH1L DMXL2 WDR64 NEDD1 WDR59 EML5 CIAO1 BRWD1	1.19e-03	272	143	8	IPR001680
Domain	WD_REPEATS_1	SEH1L DMXL2 WDR64 NEDD1 WDR59 EML5 CIAO1 BRWD1	1.37e-03	278	143	8	PS00678
Domain	Spectrin_repeat	SYNE1 MACF1 DMD	1.39e-03	29	143	3	IPR002017
Domain	WD_REPEATS_2	SEH1L DMXL2 WDR64 NEDD1 WDR59 EML5 CIAO1 BRWD1	1.40e-03	279	143	8	PS50082
Domain	WD_REPEATS_REGION	SEH1L DMXL2 WDR64 NEDD1 WDR59 EML5 CIAO1 BRWD1	1.40e-03	279	143	8	PS50294
Domain	KRAB	ZNF93 ZNF671 ZFP90 ZNF677 ZNF33B ZNF790 ZNF611 ZNF75A ZNF91	1.77e-03	358	143	9	PS50805
Domain	KRAB	ZNF93 ZNF671 ZFP90 ZNF677 ZNF33B ZNF790 ZNF611 ZNF75A ZNF91	1.77e-03	358	143	9	PF01352
Domain	KRAB	ZNF93 ZNF671 ZFP90 ZNF677 ZNF33B ZNF790 ZNF611 ZNF75A ZNF91	2.18e-03	369	143	9	SM00349
Domain	KRAB	ZNF93 ZNF671 ZFP90 ZNF677 ZNF33B ZNF790 ZNF611 ZNF75A ZNF91	2.22e-03	370	143	9	IPR001909
Domain	-	NLGN4Y NLGN1 LIPA NLGN4X SERAC1	2.23e-03	119	143	5	3.40.50.1820
Domain	AB_hydrolase	NLGN4Y NLGN1 LIPA NLGN4X SERAC1	2.23e-03	119	143	5	IPR029058
Domain	zf-C2H2_6	ZNF93 ZNF671 ZFP90 ZNF677 ZNF790 ZNF611 ZNF75A ZNF91	2.92e-03	314	143	8	PF13912
Domain	TUDOR	TDRD7 TDRD6	4.99e-03	14	143	2	PF00567
Domain	Ald_DH_CS_GLU	ALDH8A1 ALDH4A1	6.51e-03	16	143	2	IPR029510
Domain	zf-C2H2	ZNF93 ZNF671 ZFP90 ZHX2 ZNF677 ZNF33B ZNF296 ZNF790 ZNF611 ZNF75A ZFHX3 ZNF91	7.05e-03	693	143	12	PF00096
Domain	Ald_DH_CS_CYS	ALDH8A1 ALDH4A1	7.34e-03	17	143	2	IPR016160
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AKAP6 DMXL2 PDE2A ITCH NRCAM TCOF1 SYNE1 GNPTAB KCNAB2 ZMYM2 DARS1 ZNFX1 XPC MSH3 NSUN2 WDR59 CRNKL1 AP2M1 RPRD1A FAM218A USP32 SENP6 MACF1 HECTD1 GEN1 BRWD1	3.80e-11	1285	148	26	35914814
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	AKAP6 DMXL2 GBF1 SYNE1 GNPTAB CDK19 ANKRD28 MACF1 PCNX1 CDC5L	4.92e-08	225	148	10	12168954
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KNTC1 DMXL2 GBF1 GNPTAB RNF213 WDR59 AP2M1 PER3 EEPD1 MACF1 CDC5L KLHDC10 HECTD1	2.14e-07	493	148	13	15368895
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	AKAP6 SYNE1 GNPTAB ABI2 MACF1 DMD ZNF91 CDC5L	2.95e-07	151	148	8	17043677
Pubmed	Molecular analysis of mammalian timeless.	PER3 PER2 TIMELESS	3.01e-07	4	148	3	9856466
Pubmed	Analysis of four neuroligin genes as candidates for autism.	NLGN4Y NLGN1 NLGN4X	3.01e-07	4	148	3	16077734
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ITCH TCOF1 ABCA12 HAUS5 RNF213 XPC DDB1 YEATS2 RASAL3 EML5 CIAO1 SCML1 SUPT7L ANKRD28 MACF1 ZFHX3 LRRC41 SENP7 BRWD1	3.04e-07	1116	148	19	31753913
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TRPC4AP ITCH NLGN4Y CDK19 RNF213 IQCN PCGF3 NEDD1 ZHX2 SBNO2 YEATS2 ZNF33B ABCC8 EEPD1 TBCK KNDC1 UBA6 MACF1 ZFHX3 HECTD1 MCTP2 LRRC41	3.68e-07	1489	148	22	28611215
Pubmed	Characterization of functional domains in human Claspin.	POLE CDC45 TIMELESS	7.50e-07	5	148	3	21478680
Pubmed	Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.	NLGN4Y NLGN1 NLGN4X	7.50e-07	5	148	3	37865312
Pubmed	Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription.	PER3 PER2 TIMELESS	7.50e-07	5	148	3	9856465
Pubmed	Synapse formation: if it looks like a duck and quacks like a duck ...	NLGN4Y NLGN1 NLGN4X	7.50e-07	5	148	3	10996085
Pubmed	The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?	NLGN4Y NLGN1 NLGN4X	1.50e-06	6	148	3	21838267
Pubmed	A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock.	PER3 PER2 TIMELESS	1.50e-06	6	148	3	9989497
Pubmed	Molecular bases for circadian clocks.	PER3 PER2 TIMELESS	1.50e-06	6	148	3	9988221
Pubmed	Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.	NLGN4Y NLGN1 NLGN4X	1.50e-06	6	148	3	29724786
Pubmed	mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.	PER3 PER2 TIMELESS	1.50e-06	6	148	3	10428031
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NRCAM SYNE1 CDK19 NLGN1 ZHX2 YEATS2 SEMA6D PER2 MACF1 ARRDC3 SENP7	1.50e-06	407	148	11	12693553
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DMXL2 PDE2A ITCH NRCAM TCOF1 SYNE1 KCNAB2 ZMYM2 ZNFX1 DDB1 ABI2 UBA6 ANKRD28 MACF1 LAMTOR1 CDC5L	3.81e-06	963	148	16	28671696
Pubmed	Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.	POLE DDB1 CIAO1	4.16e-06	8	148	3	27235625
Pubmed	Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.	NLGN4Y NLGN1 NLGN4X	4.16e-06	8	148	3	30871858
Pubmed	DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.	NRCAM NLGN4Y NLGN1 NLGN4X	4.38e-06	26	148	4	34848499
Pubmed	Neuronal Bmal1 regulates retinal angiogenesis and neovascularization in mice.	SEMA3A SEMA6D PER2	6.23e-06	9	148	3	35933488
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	GBF1 TCOF1 ADCK5 RNF213 CDC45 AP2M1 USP32 UBA6 MACF1 KLHDC10 HECTD1	7.37e-06	481	148	11	28190767
Pubmed	Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study.	PER3 PER2 TIMELESS	8.87e-06	10	148	3	19934327
Pubmed	SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.	NLGN4Y NLGN1 NLGN4X	1.22e-05	11	148	3	32973045
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	NLGN4Y NLGN1 NLGN4X	1.22e-05	11	148	3	26403076
Pubmed	Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.	TDRD7 TDRD6	1.80e-05	2	148	2	21670278
Pubmed	Possible Association of PER2/PER3 Variable Number Tandem Repeat Polymorphism Variants with Susceptibility and Clinical Characteristics in Pancreatic Cancer.	PER3 PER2	1.80e-05	2	148	2	33393850
Pubmed	Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.	NLGN4Y NLGN4X	1.80e-05	2	148	2	23183221
Pubmed	Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.	NLGN4Y NLGN4X	1.80e-05	2	148	2	24855039
Pubmed	Requirement of mammalian Timeless for circadian rhythmicity.	PER3 TIMELESS	1.80e-05	2	148	2	14564007
Pubmed	Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.	NLGN4Y NLGN4X	1.80e-05	2	148	2	37001827
Pubmed	Knockdown of Muscle-Specific Ribosomal Protein L3-Like Enhances Muscle Function in Healthy and Dystrophic Mice.	DMD RPL3L	1.80e-05	2	148	2	34081545
Pubmed	Variants in the circadian clock genes PER2 and PER3 associate with familial sleep phase disorders.	PER3 PER2	1.80e-05	2	148	2	38695651
Pubmed	TIMELESS mutation alters phase responsiveness and causes advanced sleep phase.	PER2 TIMELESS	1.80e-05	2	148	2	31138685
Pubmed	Zfhx3-mediated genetic ablation of the SCN abolishes light entrainable circadian activity while sparing food anticipatory activity.	PER2 ZFHX3	1.80e-05	2	148	2	34632336
Pubmed	Distinct functions of Period2 and Period3 in the mouse circadian system revealed by in vitro analysis.	PER3 PER2	1.80e-05	2	148	2	20072700
Pubmed	Dopamine adjusts the circadian gene expression of Per2 and Per3 in human dermal fibroblasts from ADHD patients.	PER3 PER2	1.80e-05	2	148	2	34275001
Pubmed	Unusually rapid evolution of Neuroligin-4 in mice.	NLGN4Y NLGN4X	1.80e-05	2	148	2	18434543
Pubmed	Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.	NLGN4Y NLGN4X	1.80e-05	2	148	2	37080762
Pubmed	Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.	NLGN4Y NLGN4X	1.80e-05	2	148	2	29106499
Pubmed	Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.	NLGN4Y NLGN4X	1.80e-05	2	148	2	26456829
Pubmed	Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.	NLGN4Y NLGN4X	1.80e-05	2	148	2	24104404
Pubmed	A novel association of two non-synonymous polymorphisms in PER2 and PER3 genes with specific diurnal preference subscales.	PER3 PER2	1.80e-05	2	148	2	23969301
Pubmed	A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.	NLGN4Y NLGN4X	1.80e-05	2	148	2	32243781
Pubmed	Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.	NLGN4Y NLGN4X	1.80e-05	2	148	2	22989184
Pubmed	Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7.	SENP6 SENP7	1.80e-05	2	148	2	18799455
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	SEH1L TRPC4AP GBF1 TCOF1 POLE NEDD1 DDB1 CDC45 AP2M1 CIAO1 ANKRD28 PLD2 DMD CDC5L HECTD1	1.89e-05	974	148	15	28675297
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	NRCAM TCOF1 ZMYM2 DARS1 SEMA3A RPRD1A SEMA6D MACF1 CDC5L	2.45e-05	358	148	9	32460013
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DMXL2 NRCAM NLGN4Y SYNE1 KCNAB2 NLGN1 NLGN4X MACF1	2.92e-05	281	148	8	28706196
Pubmed	Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.	NLGN4Y NLGN1 NLGN4X	3.31e-05	15	148	3	18227507
Pubmed	CUL2LRR1 , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle.	POLE CDC45 TIMELESS	3.31e-05	15	148	3	33590678
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF355P ZNF93 ZNF91	3.31e-05	15	148	3	15885501
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	KNTC1 SEH1L TRPC4AP SYNE1 HAUS5 ZMYM2 XPC NEDD1 NSUN2 DDB1 CRNKL1 AP2M1 PER3 PER2 TIMELESS CDC5L	3.56e-05	1155	148	16	20360068
Pubmed	Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.	NRCAM SEMA3A SEMA6D	4.06e-05	16	148	3	22632726
Pubmed	PER2 variantion is associated with depression vulnerability.	PER3 PER2 TIMELESS	4.06e-05	16	148	3	19693801
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	XPC DDB1 CC2D2B YEATS2 RPRD1A ANGEL2 PLD2 CDC5L LRRC41	5.35e-05	396	148	9	26687479
Pubmed	Neuronal Localization of SENP Proteins with Super Resolution Microscopy.	SENP6 SENP7	5.38e-05	3	148	2	33113832
Pubmed	Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects.	PER3 PER2	5.38e-05	3	148	2	19013183
Pubmed	A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.	PER3 PER2	5.38e-05	3	148	2	9428527
Pubmed	Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice.	PER3 PER2	5.38e-05	3	148	2	26781276
Pubmed	Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.	PER3 PER2	5.38e-05	3	148	2	9427249
Pubmed	Association between polymorphisms in period genes and bone density in postmenopausal Korean women.	PER3 PER2	5.38e-05	3	148	2	24678593
Pubmed	Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA.	XPC DDB1	5.38e-05	3	148	2	22039351
Pubmed	For whom the circadian clock ticks? Investigation of PERIOD and CLOCK gene variants in bipolar disorder.	PER3 PER2	5.38e-05	3	148	2	34112033
Pubmed	Photic entrainment of period mutant mice is predicted from their phase response curves.	PER3 PER2	5.38e-05	3	148	2	20826680
Pubmed	mPeriod2 Brdm1 and other single Period mutant mice have normal food anticipatory activity.	PER3 PER2	5.38e-05	3	148	2	29138421
Pubmed	A time memory engram embedded in a light-entrainable circadian clock.	PER3 PER2	5.38e-05	3	148	2	37951213
Pubmed	Sex difference in daily rhythms of clock gene expression in the aged human cerebral cortex.	PER3 PER2	5.38e-05	3	148	2	23606611
Pubmed	Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function.	PER3 PER2	5.38e-05	3	148	2	22331899
Pubmed	Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes.	PER3 PER2	5.38e-05	3	148	2	15031135
Pubmed	The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15.	PER3 PER2	5.38e-05	3	148	2	29186676
Pubmed	Period determination in the food-entrainable and methamphetamine-sensitive circadian oscillator(s).	PER3 PER2	5.38e-05	3	148	2	22891330
Pubmed	Period Family of Clock Genes as Novel Predictors of Survival in Human Cancer: A Systematic Review and Meta-Analysis.	PER3 PER2	5.38e-05	3	148	2	32849922
Pubmed	Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.	PER3 PER2	5.38e-05	3	148	2	29269828
Pubmed	PER2 rs2304672, CLOCK rs1801260, and PER3 rs57875989 polymorphisms are not associated with juvenile myoclonic epilepsy.	PER3 PER2	5.38e-05	3	148	2	24892753
Pubmed	The complex relationship between the light-entrainable and methamphetamine-sensitive circadian oscillators: evidence from behavioral studies of Period-mutant mice.	PER3 PER2	5.38e-05	3	148	2	23869717
Pubmed	ARNTL, CLOCK and PER3 polymorphisms - links with chronotype and affective dimensions.	PER3 TIMELESS	5.38e-05	3	148	2	28708003
Pubmed	Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.	NLGN4Y NLGN4X	5.38e-05	3	148	2	32011705
Pubmed	Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock.	PER3 PER2	5.38e-05	3	148	2	11395012
Pubmed	Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity.	PER3 PER2	5.38e-05	3	148	2	12032351
Pubmed	Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers.	PER3 PER2	5.38e-05	3	148	2	15790588
Pubmed	Aberrant expression of Per1, Per2 and Per3 and their prognostic relevance in non-small cell lung cancer.	PER3 PER2	5.38e-05	3	148	2	25550826
Pubmed	Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes.	PER3 PER2	5.38e-05	3	148	2	18517031
Pubmed	Analysis of the neuroligin 4Y gene in patients with autism.	NLGN4Y NLGN4X	5.38e-05	3	148	2	18628683
Pubmed	A light-independent oscillatory gene mPer3 in mouse SCN and OVLT.	PER3 PER2	5.38e-05	3	148	2	9707434
Pubmed	Intracellular calcium mobilization induces period genes via MAP kinase pathways in NIH3T3 cells.	PER3 PER2	5.38e-05	3	148	2	11959112
Pubmed	Comparing expression levels of PERIOD genes PER1, PER2 and PER3 in chronic insomnia patients and medical staff working in the night shift.	PER3 PER2	5.38e-05	3	148	2	32805476
Pubmed	Nuclear export of mammalian PERIOD proteins.	PER3 PER2	5.38e-05	3	148	2	11591712
Pubmed	The role of phosphorylation and degradation of hPER protein oscillation in normal human fibroblasts.	PER3 PER2	5.38e-05	3	148	2	14712925
Pubmed	An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons.	ZNF93 ZNF91	5.38e-05	3	148	2	25274305
Pubmed	Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.	NLGN4Y NLGN4X	5.38e-05	3	148	2	21282647
Pubmed	Molecular analysis of avian circadian clock genes.	PER3 PER2	5.38e-05	3	148	2	10891604
Pubmed	UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.	XPC DDB1	5.38e-05	3	148	2	15882621
Pubmed	Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.	PER3 PER2 TIMELESS	5.88e-05	18	148	3	20174623
Pubmed	Gestational folate deficiency alters embryonic gene expression and cell function.	CUBN SEMA3A CCNG1	5.88e-05	18	148	3	33302058
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	HAUS5 DDB1 CCNG1 YEATS2 SLC8A1 RPRD1A NLGN4X ZNF296 CIAO1 EEPD1 KIF19 METTL16 TAS2R50	6.03e-05	832	148	13	36724073
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SEH1L ITCH DSG1 POLE DARS1 XPC MSH3 NSUN2 DDB1 WDR59 CDC45 CRNKL1 AP2M1 CIAO1 ANKRD28 MACF1 CDC5L	6.73e-05	1353	148	17	29467282
Pubmed	Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.	PER3 PER2 TIMELESS	6.96e-05	19	148	3	20072116
Interaction	POU5F1 interactions	ITCH TCOF1 ZMYM2 XPC CUBN DDB1 CC2D2B YEATS2 AP2M1 RPRD1A ANGEL2 ZFHX3 PLD2 CDC5L LRRC41 BRWD1	5.89e-06	584	147	16	int:POU5F1
GeneFamily	WD repeat domain containing	SEH1L DMXL2 WDR64 NEDD1 WDR59 EML5 CIAO1 BRWD1	1.45e-04	262	105	8	362
GeneFamily	SUMO specific peptidases	SENP6 SENP7	6.88e-04	7	105	2	984
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF93 ZNF671 ZFP90 ZHX2 ZNF677 ZNF33B ZNF296 ZNF790 ZNF611 ZNF75A ZFHX3 ZNF91	9.33e-04	718	105	12	28
Coexpression	GSE45365_HEALTHY_VS_MCMV_INFECTION_CD11B_DC_UP	ZNF671 TCOF1 XPC ZNF677 PER3 ZNF75A ZNF91 SENP7	1.26e-05	189	148	8	M9978
Coexpression	GSE32986_GMCSF_VS_GMCSF_AND_CURDLAN_LOWDOSE_STIM_DC_DN	DDX31 HAUS5 IQCN CUBN EML5 PER2 SCML1 ZNF91	1.69e-05	197	148	8	M8611
Coexpression	GSE17721_CTRL_VS_POLYIC_4H_BMDC_DN	ZNFX1 GSAP TDRD7 ZNF296 ABCC8 PCNX1 RBM43 LRRC41	1.89e-05	200	148	8	M3714
Coexpression	GSE21670_UNTREATED_VS_IL6_TREATED_CD4_TCELL_DN	ITCH SYNE1 SPO11 XPC LIPA RASAL3 SENP6 ALDH4A1	1.89e-05	200	148	8	M7441
Coexpression	GSE40068_BCL6_POS_VS_NEG_CXCR5_POS_TFH_DN	ZMYM2 IRF6 ST8SIA1 LIPA USP32 SENP6 SERAC1 ARRDC3	1.89e-05	200	148	8	M9260
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	SEH1L ITCH GBF1 MRPL30 TDRD7 ANGEL2 PLD2	2.25e-06	178	148	7	536a601abcc60867949ea06e9aafb6c7b799b56b
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Grin2c_(SNc)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TRPA1 ABCA12 ALDH8A1 TERT RPL3L	2.54e-06	65	148	5	acc541e5a0e4be5ddd5702f191185c5b405b8762
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Grin2c_(SNc)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TRPA1 ABCA12 ALDH8A1 TERT RPL3L	2.54e-06	65	148	5	b8ab40d75b4078123cdffec2f5326cff65f67578
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	KNTC1 DMXL2 GBF1 GNPTAB RNF213 MACF1 MCTP2	2.91e-06	185	148	7	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	KNTC1 DMXL2 GBF1 GNPTAB RNF213 MACF1 MCTP2	3.01e-06	186	148	7	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	KNTC1 GBF1 GNPTAB RNF213 TBCK MACF1 MCTP2	3.59e-06	191	148	7	9454f642c3621370fa23640b631301346b300950
ToppCell	Control-NK\|Control / Disease condition and Cell class	SYNE1 GNPTAB RNF213 GSAP CATSPER1 MACF1 MCTP2	4.70e-06	199	148	7	f3316fb97c6065286ffd22a0ad9fe7aa5b3b5650
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCA12 ITGA8 C8orf48 SEMA3A ZFHX3 MCTP2	1.97e-05	166	148	6	739dfbe927f409821ff23aca6e47ebe78f57e859
ToppCell	E12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PDE2A TDRD7 YEATS2 USP32 KLHDC10 FBXO15	2.41e-05	172	148	6	3b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KNTC1 DDX31 INPPL1 IRF6 SBNO2 TBCK	2.41e-05	172	148	6	1bbf5ed7d13635f9a7e528060341e0652699bd7c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE1 ITGA8 ERN2 CDC45 CATSPER1 CFAP161	2.49e-05	173	148	6	f193c63cc536d891c9d23043765e320252bb6e65
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DMXL2 INPPL1 ZHX2 SLC8A1 EEPD1 ARRDC3	2.83e-05	177	148	6	f28243b51be104cb3adcde63f03fc2206ed3121e
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SEH1L ITCH GBF1 MRPL30 TDRD7 ANGEL2	2.92e-05	178	148	6	9d575902d3dbe33437c9d4200df093a741269803
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	IQCN NLGN4X SEMA6D EEPD1 MYO3B HECTD1	3.30e-05	182	148	6	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NLGN4Y SLC8A1 SEMA6D ZFHX3 DMD MCTP2	3.41e-05	183	148	6	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F NRCAM ABCA12 SLC8A1 DMD USH2A	3.51e-05	184	148	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F NRCAM ABCA12 SLC8A1 DMD USH2A	3.51e-05	184	148	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F NRCAM ABCA12 SLC8A1 DMD USH2A	3.51e-05	184	148	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Ciliated-cil-3\|World / Class top	SYNE1 KIF19 KNDC1 ULK4 CFAP161 SERPINA9	4.45e-05	192	148	6	4989ebb8812b8af1870599acd932849122c05a29
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NRCAM SEMA6D EDAR ZFHX3 DMD MCTP2	4.58e-05	193	148	6	000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	AKAP6 FBXL13 SYNE1 DNAH12 ULK4 DMD	4.58e-05	193	148	6	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	SYNE1 POLE RNF213 ZHX2 YEATS2 MACF1	5.28e-05	198	148	6	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	healthy_donor-Lymphocytic-ILC-NK_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	SYNE1 GNPTAB RNF213 GSAP MACF1 MCTP2	5.28e-05	198	148	6	d7053a898e04478c577381085f615edaad3cdc5b
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 GNPTAB RNF213 GSAP MACF1 MCTP2	5.28e-05	198	148	6	0e918e9db9b884f5328d438e90efe065e27266ee
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 GNPTAB RNF213 GSAP MACF1 MCTP2	5.28e-05	198	148	6	ce92d5fbc2eac27fb246b044fb1914ab92506275
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNE1 GNPTAB RNF213 GSAP MACF1 MCTP2	5.28e-05	198	148	6	fed823d6e684d113bcc9ff3cd1803bb001aa02fa
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AKAP6 NRCAM SYNE1 ITGA8 NLGN1 SLC8A1	5.28e-05	198	148	6	c12e7511628db819a52959bb68580e27c00c2e41
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DMXL2 KCNAB2 CDCP1 SLC8A1 LIPA EEPD1	5.28e-05	198	148	6	0b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCell	healthy_donor-Lymphocytic-ILC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	SYNE1 GNPTAB RNF213 GSAP MACF1 MCTP2	5.28e-05	198	148	6	aa33be29e26f1b8facfc894413099083ae3bbb1b
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SYNE1 GNPTAB RNF213 GSAP MACF1 MCTP2	5.28e-05	198	148	6	1ef3a6bd681c223eed58300348adfef89df5563c
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AKAP6 NRCAM SYNE1 ITGA8 NLGN1 SLC8A1	5.28e-05	198	148	6	22e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	AKAP6 SYNE1 SLC8A1 ZFHX3 DMD MCTP2	5.58e-05	200	148	6	f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AKAP6 SYNE1 ITGA8 SEMA6D ZFHX3 DMD	5.58e-05	200	148	6	b22cae282591d8dead9869c2adbb9632615f50f7
ToppCell	Control-Control-Lymphocyte-T/NK-NK\|Control / Disease, condition lineage and cell class	SYNE1 GNPTAB RNF213 GSAP MACF1 MCTP2	5.58e-05	200	148	6	c64c27dbf4df42ca2ad2bd94b50fab87b4050ef3
ToppCell	mild-NK\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 GNPTAB RNF213 GSAP MACF1 MCTP2	5.58e-05	200	148	6	a11fb1d7e124c352eb73fea0e0ec0fed577c97f7
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-NK_activated\|COVID-19_Severe / Disease, condition lineage and cell class	SYNE1 GNPTAB RNF213 GSAP MACF1 MCTP2	5.58e-05	200	148	6	6a77f9643646bafc1157bf1fc1e4c614860ee642
Drug	Nisoxetine hydrochloride [57754-86-6]; Down 200; 13uM; MCF7; HT_HG-U133A	ZNF93 TRPC4AP GSAP PCGF3 ERN2 TDRD7 PER3 EDAR PCNX1 ALDH4A1 METTL16	6.75e-08	199	146	11	6496_DN
Drug	5248896; Down 200; 11uM; MCF7; HT_HG-U133A_EA	TRPC4AP DDX31 CDK19 IRF6 PEX11A PER3 SUPT7L SENP6 MACF1	5.49e-06	198	146	9	955_DN
Drug	Cefuroxime sodium salt [56238-63-2]; Down 200; 9uM; MCF7; HT_HG-U133A	KCNAB2 IRF6 PPP1R14D PEX11A YEATS2 EDAR ANGEL2 TIMELESS PLD2	5.72e-06	199	146	9	6088_DN
Disease	advanced sleep phase syndrome (is_implicated_in)	PER3 PER2 TIMELESS	4.08e-07	4	139	3	DOID:0050628 (is_implicated_in)
Disease	Malignant neoplasm of breast	AKAP6 PDE2A MAN2C1 NRCAM SYNE1 CUBN TERT SEMA3A RPRD1A PER3 PER2 ZNF75A MACF1 TIMELESS ARRDC3 PLD2 DMD KLHDC10 GEN1	7.44e-07	1074	139	19	C0006142
Disease	response to cold	AKAP6 ST8SIA1	6.59e-05	3	139	2	GO_0009409
Disease	Advanced Sleep-Phase Syndrome, Familial	PER3 PER2	6.59e-05	3	139	2	C1858496
Disease	bombesin receptor-activated protein C6orf89 measurement	CUBN RASAL3	2.18e-04	5	139	2	EFO_0801428
Disease	brain edema (implicated_via_orthology)	ABCC8 DMD	3.26e-04	6	139	2	DOID:4724 (implicated_via_orthology)
Disease	xeroderma pigmentosum (implicated_via_orthology)	XPC DDB1	3.26e-04	6	139	2	DOID:0050427 (implicated_via_orthology)
Disease	sleep duration	GBF1 METTL4 SLC8A1 SEMA6D MYO3B TBCK PLD2 FBXO15	3.32e-04	362	139	8	EFO_0005271
Disease	Myeloid Leukemia, Chronic	TERT PER3 PER2	3.42e-04	29	139	3	C0023473
Disease	osteoarthritis, spine, body mass index	NLGN1 PER3	6.06e-04	8	139	2	EFO_0004340, EFO_1000787
Disease	lung cancer (implicated_via_orthology)	POLE XPC	7.76e-04	9	139	2	DOID:1324 (implicated_via_orthology)
Disease	status epilepticus (biomarker_via_orthology)	NLGN1 SLC8A1 ABCC8 DMD	1.30e-03	100	139	4	DOID:1824 (biomarker_via_orthology)
Disease	Intellectual Disability	AKAP6 SYNE1 ZMYM2 NSUN2 AP2M1 MACF1 SERAC1 ALDH4A1	1.31e-03	447	139	8	C3714756
Disease	endometrial carcinoma (is_implicated_in)	POLE MSH3	1.41e-03	12	139	2	DOID:2871 (is_implicated_in)
Disease	metabolite measurement, body weight gain	KIF19 ZFHX3	1.41e-03	12	139	2	EFO_0004566, EFO_0004725
Disease	outer ear morphology trait	EDAR MYO3B	1.41e-03	12	139	2	EFO_0007664
Disease	Myeloproliferative disease	ZMYM2 TERT	1.41e-03	12	139	2	C0027022
Disease	amino acid measurement	ABCA12 SYNE1 NLGN1 ST8SIA1 DNAH12 RASAL3 PER3 SENP6 ULK4 MCTP2	1.44e-03	678	139	10	EFO_0005134
Disease	Colorectal Carcinoma	AKAP6 NRCAM TCOF1 ABCA12 SYNE1 POLE CUBN NLGN4X ABCC8 DMD	1.86e-03	702	139	10	C0009402
Disease	lobe size	EDAR MYO3B	1.93e-03	14	139	2	EFO_0007666
Disease	Drug habituation	NRCAM SYNE1 CDCP1 SEMA6D	2.18e-03	115	139	4	C0013170
Disease	Drug abuse	NRCAM SYNE1 CDCP1 SEMA6D	2.18e-03	115	139	4	C0013146
Disease	Prescription Drug Abuse	NRCAM SYNE1 CDCP1 SEMA6D	2.18e-03	115	139	4	C4316881
Disease	Substance-Related Disorders	NRCAM SYNE1 CDCP1 SEMA6D	2.18e-03	115	139	4	C0236969
Disease	Drug Use Disorders	NRCAM SYNE1 CDCP1 SEMA6D	2.18e-03	115	139	4	C0013222
Disease	Drug Dependence	NRCAM SYNE1 CDCP1 SEMA6D	2.18e-03	115	139	4	C1510472
Disease	Substance Dependence	NRCAM SYNE1 CDCP1 SEMA6D	2.18e-03	115	139	4	C0038580
Disease	Substance Use Disorders	NRCAM SYNE1 CDCP1 SEMA6D	2.18e-03	115	139	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	NRCAM SYNE1 CDCP1 SEMA6D	2.18e-03	115	139	4	C0029231
Disease	Substance abuse problem	NRCAM SYNE1 CDCP1 SEMA6D	2.25e-03	116	139	4	C0740858
Disease	body weight	AKAP6 KNTC1 NRCAM NLGN1 WDR59 SBNO2 DNAH12 SEMA6D PEMT ABCC8 SENP6 ULK4 ZFHX3 DMD	2.57e-03	1261	139	14	EFO_0004338
Disease	Mammary Carcinoma, Human	PDE2A MAN2C1 NRCAM SYNE1 TERT PER3 ARRDC3 KLHDC10	3.52e-03	525	139	8	C4704874
Disease	Mammary Neoplasms, Human	PDE2A MAN2C1 NRCAM SYNE1 TERT PER3 ARRDC3 KLHDC10	3.52e-03	525	139	8	C1257931
Disease	Mammary Neoplasms	PDE2A MAN2C1 NRCAM SYNE1 TERT PER3 ARRDC3 KLHDC10	3.60e-03	527	139	8	C1458155
Disease	QT interval	GBF1 KCNAB2 SLC8A1 PEMT ABCC8 ZFHX3 CFAP161 BRWD1	3.90e-03	534	139	8	EFO_0004682
Disease	Breast Carcinoma	PDE2A MAN2C1 NRCAM SYNE1 TERT PER3 ARRDC3 KLHDC10	4.07e-03	538	139	8	C0678222
Disease	periodontitis	AKAP6 ITGA8 NLGN1 ZFHX3 DMD	4.18e-03	223	139	5	EFO_0000649
Disease	ovarian carcinoma	ZFP90 NLRP1 CDCP1 TERT ZFHX3 DMD	4.24e-03	321	139	6	EFO_0001075
Disease	lung non-small cell carcinoma (is_implicated_in)	POLE MSH3 TERT ZFHX3	4.30e-03	139	139	4	DOID:3908 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VHRVAKKLQSGLVWT	ALDH8A1	431	Q9H2A2
AFKKWHQRLAARSPR	C1orf167	1411	Q5SNV9
WSRIASLLHRKSAKQ	CDC5L	31	Q99459
LQKVFLSHSDRKVWL	CDK19	81	Q9BWU1
RTRKKGHSTNLFQWL	CATSPER1	411	Q8NEC5
LNRTFIWDVKAHKSI	CDCP1	121	Q9H5V8
AILIKRFHHTRRNWK	ABCA12	1731	Q86UK0
RVNAKDSKWLTPLHR	ANKRD28	66	O15084
SFARIKKWLEHARSS	ALDH4A1	396	P30038
PRVHWDKSSKRVLTA	ADCK5	301	Q3MIX3
SIKQGVKSRWVLLRS	DMXL2	1221	Q8TDJ6
HRTLLKSSKRSWLQE	CFAP161	166	Q6P656
WSELRKKSLNIRSHL	DMD	2786	P11532
SSKRRKHQGVIKRNW	ANGEL2	121	Q5VTE6
LRTWKQIKSLRHGQG	CC2D2B	391	Q6DHV5
KSLKKVFTGHWAVVR	EEPD1	496	Q7L9B9
SLKIHARGHAKVRWT	ARRDC3	46	Q96B67
HGVKWLLRFKVSTQN	ABI2	151	Q9NYB9
SRLRLSKALWGRHKN	RASAL3	81	Q86YV0
KHWLARKTRHAELTV	RBM43	81	Q6ZSC3
GKDHTLKFVVVTRWR	PCGF3	211	Q3KNV8
KWFLILRGQQRAVSH	ARHGAP36	96	Q6ZRI8
HIQRQVAKRVWKSSP	ARHGAP36	431	Q6ZRI8
AWRRFNKRHILHSSK	IQCN	136	Q9H0B3
AWHTNLSRKILRKSP	NSUN2	126	Q08J23
IWKRLTEKSHIRYSG	C8orf48	261	Q96LL4
KWIVSGRTARQLKHS	CCNG1	266	P51959
RIFKVTRHWASLSNL	CACNA1F	631	O60840
LWVLDHTKTSFGRRK	MSH3	561	P20585
WRATLKTIRNGVHKI	PLA2G12A	31	Q9BZM1
PIKRHRLASWIKSQD	nan	21	O00370
KRHRWSNRKRLSASK	MCTP2	321	Q6DN12
VNIWDLKSKRVHRSL	NEDD1	101	Q8NHV4
IRHASIANKWKTIHL	GNPTAB	586	Q3T906
WKTQSSSKRNRRHIE	NRCAM	886	Q92823
HALSKQTGDLKWTLR	ERN2	51	Q76MJ5
VKTWRHLAESFGLKR	EDAR	371	Q9UNE0
WSRKISFIIGRHKVR	PER2	421	O15055
NIRNFIVSTWHRLRK	PCNX1	2021	Q96RV3
NPWSRKISFIIGRHK	PER3	361	P56645
IHENKRTGSLFKIWL	KLHDC10	386	Q6PID8
NREHWTKVSHKFTIR	PDE2A	891	O00408
KLQLIEGRQHRSTWS	NLRP1	766	Q9C000
VLRTTLKHSNVWRKH	FAM214A	781	Q32MH5
QRSLHQSWEKRIVFS	FAM218A	71	Q96MZ4
RRWLFQLTKTVIKDH	DNAH12	2141	Q6ZR08
LTAIENSWIHLRRKK	METTL16	371	Q86W50
RKVLKAISSIHSLWQ	KNTC1	1996	P50748
FHVKRSNIWLAAVTK	AP2M1	56	Q96CW1
RKHFLRKWLKSSSLQ	POLE	1106	Q07864
HSQRTVKKIRGNLLW	HAUS5	51	O94927
TRRKTLLALFTDHQW	NLGN1	491	Q8N2Q7
IKSTKNIHFSRLRWL	DDX31	371	Q9H8H2
VHSSERRVSWAKKAL	DDX31	701	Q9H8H2
NGTIKWHSIRRQKRE	DSG1	36	Q02413
VLKVRSRLWAHTFLQ	ITGA8	946	P53708
KGWRRSSLVITTKIF	KCNAB2	106	Q13303
TTIKHWITIIRARFE	MACF1	6846	Q9UPN3
VVARWEHKTRKLSRA	PEMT	31	Q9UBM1
KRWRKHGVFVLLTTA	GPRC5C	236	Q9NQ84
RHLLTIAGWKHEKSR	KIF19	456	Q2TAC6
VSKLHFRVWSHQTLK	ITCH	76	Q96J02
RRKTLVALFTDHQWV	NLGN4Y	436	Q8NFZ3
HIKSITNSVWIRFKI	CUBN	786	O60494
WHNLISEEKTGKRRS	GSAP	551	A4D1B5
TAARFKLWSVHGQKR	CDC45	296	O75419
RLLQRTQHVKVWISF	CRNKL1	701	Q9BZJ0
LRHWKLTGTNKSIRK	HECTD1	1926	Q9ULT8
KRKGIERWHRAVSTN	C3orf49	36	Q96BT1
KTPTKHRLRWHSLIA	FBXO15	256	Q8NCQ5
HLVETLKFAKGQRWR	GGT5	321	P36269
KLTIILTKWRNTARH	FBXL13	86	Q8NEE6
KIWSTHNGRLLSTLR	BRWD1	211	Q9NSI6
ALKHWRTTLERVEKF	MAN2C1	6	Q9NTJ4
RLAVLSSSLTHWKKL	LAMTOR1	91	Q6IAA8
WSQKTGRSHFKSVLR	GEN1	101	Q17RS7
VVGAIKRNARWSTHT	GBF1	16	Q92538
AHRWSKLRNIAKVVS	KNDC1	1666	Q76NI1
HVKFWTLAGRALLSK	EML5	1536	Q05BV3
KLRGQSHWVKRTTLV	SEH1L	96	Q96EE3
RRKTLVALFTDHQWV	NLGN4X	436	Q8N0W4
VIKSVGKIEHSFWRS	DDB1	1061	Q16531
TWVTNRQKHLRFIKE	METTL4	326	Q8N3J2
KKVHWASGRRRTSST	PPP1R14D	21	Q9NXH3
RDSKRFQIPWKHATR	IRF6	31	O14896
SFILIWRTKKLKHTF	TAS2R50	276	P59544
SRTIHIQWKQPRKIS	USH2A	2156	O75445
FVKTQGSRKAHVRWE	USH2A	2336	O75445
LVDTTHLKRFGLWKS	SENP7	561	Q9BQF6
VSKIQRFHARSLWTN	SCML1	86	Q9UN30
HWRDIRNIIKFTGSL	SERAC1	26	Q96JX3
EFWIRLRKHNVTFSK	TDRD6	501	O60522
KLIWRKHSASALVLH	TRPC4AP	426	Q8TEL6
TWHRVRKTTQEQLKR	TLR10	616	Q9BXR5
WIRHKFTRSRIPEKV	MRPL30	31	Q8TCC3
RTFTKWINSHLAKRK	SYNE1	31	Q8NF91
THWQQTSELGRKRKA	TCOF1	51	Q13428
TALKKGLSTQAIWRR	LRRC41	91	Q15345
RGVKGVTSRWHTKKL	RPL3L	226	Q92901
LHKQDSSGLRLWKRR	PLEKHA4	61	Q9H4M7
RRNKIKTLSNLFWGH	INSL6	151	Q9Y581
WTTFTHDRIRQLIKS	INPPL1	356	O15357
KFWKSRGIHAKRLST	ST8SIA1	261	Q92185
HLRGRKKALWFSVSN	SBNO2	296	Q9Y2G9
WVRARVHTSRAKGKQ	DARS1	61	P14868
TSGINKEKWRTRAAH	PEX11A	111	O75192
HRSLVNKWTTFLKAR	SEMA3A	276	Q14563
GSVLSLQKFWQHRIK	SUPT7L	226	O94864
GKWLRVEITNVHSSR	TDRD7	716	Q8NHU6
LSARTLRKWSHSLQK	SERPINA9	286	Q86WD7
EWTGLKVAKRLHRSL	ABCC8	1086	Q09428
KRQHSWILRALDTIK	AKAP6	876	Q13023
LSEGHQRTVRKVAWS	CIAO1	56	O76071
SWRKSTTHLGSRRKF	CLECL1	31	Q8IZS7
HNRITVFLSTWNKLR	RNF213	4826	Q63HN8
VKDFQRKGTHIVLWT	TIMELESS	876	Q9UNS1
VRKTKIRNGISFTIW	UBA6	941	A0AVT1
KAFIWSSVLTRHKRV	ZNF93	376	P35789
KAFTQRPNLIRHWKV	ZNF671	486	Q8TAW3
SRWNTVLRAVKAKTH	TRPA1	1101	O75762
KAFWEKSHLTRHQRV	ZNF33B	336	Q06732
NTRLLVKKLWDTFHV	SPO11	256	Q9Y5K1
KWNTTARVFSHIRLG	SLC35A5	216	Q9BS91
KKHLGRVLSIWEERS	RPRD1A	101	Q96P16
LSAVQTRGIKHRIKW	PRND	21	Q9UKY0
TRGIKHRIKWNRKAL	PRND	26	Q9UKY0
LSIQQKRHGRVKTWT	SENP6	731	Q9GZR1
AKFRRVLKAWVVSHP	TBCK	526	Q8TEA7
QVHEWLAKKRLSFTS	ZNFX1	1736	Q9P2E3
HRKISRQSKWDIGAV	WDR59	51	Q6PJI9
KAFIKRSHLWGHQRT	ZNF677	466	Q86XU0
LRLSFGTVFRHWKKN	ZMYM2	1236	Q9UBW7
GKAFIWSSTLTRHKR	ZNF91	776	Q05481
IRIWFATQRLKHGIS	ZHX2	306	Q9Y6X8
KSFIWGSQLTRHKKI	ZNF790	541	Q6PG37
KAFVWSSQLAKHTRI	ZNF611	461	Q8N823
FFLLVRSLWRHTKQI	TAS2R8	201	Q9NYW2
ARTWHKLIKTRQEQG	TTC37	136	Q6PGP7
AFKWSSELTIHQRIR	ZNF355P	371	Q9NSJ1
KRFRWSSDLNKHLTT	ZNF75A	196	Q96N20
VHTLHSRDTWLKKAR	XPC	681	Q01831
SQRVLEKHWTSFLKA	SEMA6D	266	Q8NFY4
SRDKSLWKHFRAVSL	RNF145	371	Q96MT1
ARHFIQRWNFTKTTK	PLD2	556	O14939
WSKLQSIGIRQHLKR	TERT	581	O14746
HLKRFQFVNGRWIKS	USP32	1281	Q8NFA0
SRREPSINHFVKKVW	YEATS2	241	Q9ULM3
WVRLTREIKHKNIVT	ULK4	46	Q96C45
KTFLWKTQLTEHQRI	ZFP90	261	Q8TF47
KFKQLLSWRAHSLEI	WDR64	856	B1ANS9
RCGKQFTVAWKLLRH	ZNF296	161	Q8WUU4
KAKTALEAHIRSRHW	ZFHX3	2721	Q15911
RGNTWSRKHKTLSVS	LIPA	121	P38571
VSFQHLRKLTVLKLW	LRRC8C	631	Q8TDW0
RKIKHLRVFFVTAAW	SLC8A1	196	P32418
SRLDHWVLGKTKVFL	MYO3B	1031	Q8WXR4