Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionS-adenosyl-L-methionine binding

SETD6 METTL14

3.16e-0423232GO:1904047
GeneOntologyMolecularFunctionchromatin DNA binding

H2AB1 H2AB2 DDX17

9.00e-04167233GO:0031490
GeneOntologyCellularComponentnucleosome

H2AB1 H2AB2 EPC1

4.53e-04138233GO:0000786
GeneOntologyCellularComponentchromatin

DDX21 H2AB1 EGR4 H2AB2 SCX BCL7C EPC1

7.86e-041480237GO:0000785
GeneOntologyCellularComponenteuchromatin

H2AB1 H2AB2

2.82e-0372232GO:0000791
DomainGSDH

HHIP HHIPL1

4.74e-063242PF07995
DomainGlc/Sorbosone_DH

HHIP HHIPL1

4.74e-063242IPR012938
DomainFolate_rcpt-like

HHIP HHIPL1

4.41e-058242IPR018143
DomainFolate_rec

HHIP HHIPL1

4.41e-058242PF03024
DomainQuinoprot_gluc/sorb_DH

HHIP HHIPL1

1.04e-0412242IPR011041
DomainHISTONE_H2A

H2AB1 H2AB2

3.27e-0421242PS00046
DomainH2A

H2AB1 H2AB2

3.94e-0423242SM00414
DomainHistone_H2A

H2AB1 H2AB2

3.94e-0423242IPR002119
DomainDEAD_ATP_HELICASE

DDX21 DDX17

7.19e-0431242PS00039
DomainRNA-helicase_DEAD-box_CS

DDX21 DDX17

8.15e-0433242IPR000629
DomainRNA_helicase_DEAD_Q_motif

DDX21 DDX17

1.03e-0337242IPR014014
DomainQ_MOTIF

DDX21 DDX17

1.03e-0337242PS51195
Domain-

HHIP HHIPL1

1.14e-03392422.120.10.30
Domain6-blade_b-propeller_TolB-like

HHIP HHIPL1

1.58e-0346242IPR011042
DomainHistone

H2AB1 H2AB2

2.34e-0356242PF00125
DomainHistone_H2A/H2B/H3

H2AB1 H2AB2

2.34e-0356242IPR007125
Domain-

H2AB1 H2AB2

3.52e-03692421.10.20.10
DomainDEAD

DDX21 DDX17

3.93e-0373242PF00270
DomainDEAD/DEAH_box_helicase_dom

DDX21 DDX17

3.93e-0373242IPR011545
DomainHistone-fold

H2AB1 H2AB2

5.05e-0383242IPR009072
DomainHelicase_C

DDX21 DDX17

8.27e-03107242PF00271
DomainHELICc

DDX21 DDX17

8.27e-03107242SM00490
DomainHelicase_C

DDX21 DDX17

8.42e-03108242IPR001650
DomainHELICASE_CTER

DDX21 DDX17

8.57e-03109242PS51194
DomainHELICASE_ATP_BIND_1

DDX21 DDX17

8.57e-03109242PS51192
DomainDEXDc

DDX21 DDX17

8.57e-03109242SM00487
DomainHelicase_ATP-bd

DDX21 DDX17

8.72e-03110242IPR014001
Pubmed

Gene editing of the multi-copy H2A.B gene and its importance for fertility.

H2AB1 H2AB2

4.56e-07224230704500
Pubmed

Histone variants at the transcription start-site.

H2AB1 H2AB2

4.56e-07224224768041
Pubmed

A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B.

H2AB1 H2AB2

4.56e-07224228234895
Pubmed

Histone variant selectivity at the transcription start site: H2A.Z or H2A.Lap1.

H2AB1 H2AB2

4.56e-07224224213378
Pubmed

H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis.

H2AB1 H2AB2

4.56e-07224220008104
Pubmed

A unique H2A histone variant occupies the transcriptional start site of active genes.

H2AB1 H2AB2

1.37e-06324222139013
Pubmed

Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21.

DDX21 METTL14

1.37e-06324238387756
Pubmed

Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA.

H2AB1 H2AB2

1.37e-06324215257289
Pubmed

Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells.

H2AB1 H2AB2

1.37e-06324222795134
Pubmed

Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.2.

H2AB1 H2AB2

2.74e-06424233073403
Pubmed

Biparental contributions of the H2A.B histone variant control embryonic development in mice.

H2AB1 H2AB2

4.56e-06524233362208
Pubmed

Distinct DDX DEAD-box RNA helicases cooperate to modulate the HIV-1 Rev function.

DDX21 DDX17

6.83e-06624223608157
Pubmed

Investigation of the factor VIII intron 22 repeated region (int22h) and the associated inversion junctions.

H2AB1 H2AB2

6.83e-0662428528212
Pubmed

Host cell targets of tegument protein VP22 of herpes simplex virus 1.

U2AF1 SCX

9.56e-06724221424732
Pubmed

Evolutionary origins and diversification of testis-specific short histone H2A variants in mammals.

H2AB1 H2AB2

1.27e-05824229549088
Pubmed

A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome.

H2AB1 H2AB2

1.27e-05824211266453
Pubmed

Nucleosome adaptability conferred by sequence and structural variations in histone H2A-H2B dimers.

H2AB1 H2AB2

2.05e-051024225731851
Pubmed

Every amino acid matters: essential contributions of histone variants to mammalian development and disease.

H2AB1 H2AB2

2.05e-051024224614311
Pubmed

EGR1 and EGR2 involvement in vertebrate tendon differentiation.

EGR4 SCX

3.54e-051324221173153
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

SETD6 METTL14 EPC1

1.70e-0415724330186101
Pubmed

Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature.

SCX HHIP

1.71e-042824231719045
Pubmed

Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin.

DDX21 DDX17

1.96e-043024224140279
Pubmed

Proteomic analysis of complexes formed by human topoisomerase I.

DDX21 DDX17

2.24e-043224215848144
Pubmed

Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF).

DDX21 U2AF1 DDX17

3.03e-0419124321907836
Pubmed

Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.

DDX21 DDX17

3.50e-044024223825951
Pubmed

Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.

DDX21 U2AF1 DDX17

3.78e-0420624322174317
Pubmed

The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.

DDX21 U2AF1 DDX17

5.83e-0423924326641092
Pubmed

Comprehensive interactome of Otx2 in the adult mouse neural retina.

U2AF1 DDX17

6.16e-045324226426291
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

DDX21 U2AF1 DDX17 BCL7C

6.32e-0458224420467437
Cytoband15q11.2

GOLGA6L2 ATP10A

3.65e-0317224215q11.2
CytobandXq28

H2AB1 H2AB2

3.82e-03176242Xq28
CytobandEnsembl 112 genes in cytogenetic band chrXq28

H2AB1 H2AB2

5.53e-03213242chrXq28
GeneFamilyDEAD-box helicases

DDX21 DDX17

4.04e-0442132499
GeneFamilyHistones

H2AB1 H2AB2

3.04e-03116132864
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP10A SCX HHIP

7.12e-05151243f3406094ce79cc80398b82d58ca6fd87a96e68d4
ToppCellfacs-Lung-EPCAM-24m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP10A SCX HHIP

7.12e-05151243523dcd243c285a6b74830a93c82cca8784edd658
ToppCellInfluenza_Severe-B_memory|World / Disease group and Cell class

WEE1 EGR4 HHIP

8.77e-0516224321eb96cd4fecd85dd6acbbc3760944fa1a7cff42
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

WEE1 BSPRY EYA1

9.94e-05169243d382a76d85875663502cc7dde2e3e0682605768e
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCX HHIP SETD6

1.03e-0417124309e653973962fb884878089d281f0947f7a285f6
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCX HHIP SETD6

1.03e-0417124382de2885c8ce4fb7776da6a0207b3355c0910121
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ATP10A NAGS HHIPL1

1.05e-04172243c3a99828838af3b85c8c885d69cc8018f55ced50
ToppCellfacs-Lung-24m-Mesenchymal-myofibroblast-myofibroblast_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATP10A SCX HHIP

1.08e-04174243eb8012823b08729b462d1e5212f4873bb6b4eb1e
ToppCellfacs-Lung-24m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATP10A SCX HHIP

1.08e-0417424332fdeeebeeeca657eac6329caad4c28ca54e4d1c
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP10A HHIP ADCY5

1.08e-041742434da79da7a09ee1e345102c5331675ebcdbe56171
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCX HHIP ADCY5

1.20e-04180243573308d43425d9fba20787abdb7f8efefc48efb5
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCX HHIP ADCY5

1.20e-04180243d67d3196e6cc3dcd31023a4dc69310226181d583
ToppCellE15.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

BMP1 SCX BSPRY

1.43e-041912436f5d91a9583bbb30dfaa30dd9c7772995a9196be
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SCX HHIP ADCY5

1.43e-04191243b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCellE15.5-Epithelial-epithelial_progenitor_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

BMP1 SCX BSPRY

1.45e-04192243cb6f42dcffe650f7958543531d8f5412b2f2eb12
ToppCelldroplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SCX HHIP ADCY5

1.47e-041932432b80991e7ba7640f7ab2139d30e4c54d8e533862
ToppCelldroplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SCX HHIP ADCY5

1.47e-0419324390cfc34c2d0d7c70f071703d35db1d6037961481
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

U2AF1 GIGYF1 BCL7C

1.52e-041952432c03d1a2f208b6737311458a4bd8f2e4444de29a
ToppCellfacs-Skin-Skin_Anagen|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

U2AF1 GIGYF1 BCL7C

1.52e-04195243ffd87cc7ae9b141bf48e072ea1a1420794499790
ToppCellfacs-Skin-Skin_Anagen-18m|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

U2AF1 GIGYF1 BCL7C

1.52e-041952430d37dd66a8d60fc9cda3d6e3c4fbe67e577b890e
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BMP1 GIGYF1 DDX17

1.61e-04199243174f6013af6eafa577f84205a62927f2b367fda3
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

SCX HHIP ADCY5

1.63e-04200243c5e051f1aac8dda376c342a9932785a23450e073
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SCX HHIP ADCY5

1.63e-04200243dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
Diseasebody height at birth

HHIP ADCY5

3.35e-0440202EFO_0006784
DiseaseHOMA-B

ATP10A ADCY5

6.34e-0455202EFO_0004469
Diseaseinsulin measurement

TBC1D30 HHIP ADCY5

7.45e-04267203EFO_0004467
Diseasemigraine disorder, type 2 diabetes mellitus

WEE1 EYA1

7.55e-0460202MONDO_0005148, MONDO_0005277
DiseaseOsteoporosis, Senile

U2AF1 ADCY5

7.80e-0461202C0029459
DiseaseOsteoporosis, Age-Related

U2AF1 ADCY5

7.80e-0461202C0001787
DiseasePost-Traumatic Osteoporosis

U2AF1 ADCY5

7.80e-0461202C0751406
DiseaseOsteoporosis

U2AF1 ADCY5

8.32e-0463202C0029456
Diseasesmoking behavior, BMI-adjusted waist circumference

HHIP EYA1

3.07e-03122202EFO_0004318, EFO_0007789
DiseaseBMI-adjusted waist circumference, physical activity measurement

HHIP EYA1

3.12e-03123202EFO_0007789, EFO_0008002
Diseasenon-alcoholic fatty liver disease

HHIP EYA1

6.68e-03182202EFO_0003095
Diseasebirth weight, parental genotype effect measurement

HHIP ADCY5

7.41e-03192202EFO_0004344, EFO_0005939
Diseasewaist-hip ratio

HHIP ADCY5 EYA1 EPC1

8.43e-031226204EFO_0004343
DiseaseFEV/FEC ratio

HHIP HHIPL1 EYA1 EPC1

8.48e-031228204EFO_0004713
Diseaseplatelet component distribution width

WEE1 ADCY5 EPC1

1.37e-02755203EFO_0007984

Protein segments in the cluster

PeptideGeneStartEntry
CIGFARRRVGRGGRV

EPC1

451

Q9H2F5
RRRGSSGAGGRGRTC

H2AB1

6

P0C5Y9
RRRGSSGAGGRGRTC

H2AB2

6

P0C5Z0
RGGDDCGRGSRRQRR

ADCY5

106

O95622
CGRGSRRQRRGAASG

ADCY5

111

O95622
RGACGRWRGRSRSRR

BMP1

106

P13497
AAGAAKGERRRRRGC

ATP10A

41

O60312
RGRGSTRSRGRGRGD

GIGYF1

116

O75420
RRGGGRRRGRLNSAS

HHIPL1

651

Q96JK4
GRERNRSNFRGERGG

METTL14

426

Q9HCE5
RRGSDGKSRGRGRRN

EYA1

296

Q99502
AGRRRCGSSRGCRNR

GOLGA6L2

691

Q8N9W4
GGARRLSCGARRRAA

NAGS

26

Q8N159
ALERRGAAARGRCGR

EGR4

31

Q05215
GLGGRCRGHRIRRAE

BSPRY

46

Q5W0U4
RAGGGAERSRGRERR

BCL7C

61

Q8WUZ0
AERSRGRERRGRGAS

BCL7C

66

Q8WUZ0
GDRDRDRDRGGFGAR

DDX17

86

Q92841
SRGFRGQRDGNRRFR

DDX21

731

Q9NR30
GQRDGNRRFRGQREG

DDX21

736

Q9NR30
SERAGGRRTRGGARA

SETD6

41

Q8TBK2
GERNEGSGARRRRCL

HHIP

26

Q96QV1
PRGCGARRAGEGRRS

WEE1

151

P30291
RALFRRRADGRGGRC

SPRED3

301

Q2MJR0
GGRGAEGRRRRRDSL

TBC1D30

101

Q9Y2I9
ERRSRSRDRGRGGGG

U2AF1

201

Q01081
RNATGRGRRRRQGGA

nan

101

Q8N1X5
RCGLQGARRRAGGRR

SCX

46

Q7RTU7