Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentCul4-RING E3 ubiquitin ligase complex

DCAF12L1 DCAF5 DCAF12

1.02e-0438503GO:0080008
DomainNUT

NUTM2F NUTM2G

6.44e-055482IPR024310
DomainNUT_N

NUTM2F NUTM2G

6.44e-055482IPR024309
DomainNUT

NUTM2F NUTM2G

6.44e-055482PF12881
DomainVps4_C

KATNA1 FIGNL1

1.79e-048482PF09336
DomainVps4_C

KATNA1 FIGNL1

1.79e-048482IPR015415
Domain-

SCAP DCAF12L1 TEP1 BIRC6 DCAF5 DCAF12

2.01e-043334862.130.10.10
DomainWD40/YVTN_repeat-like_dom

SCAP DCAF12L1 TEP1 BIRC6 DCAF5 DCAF12

2.07e-04335486IPR015943
DomainPH

RASA1 NET1 PLD1 ARHGEF3 FERMT3

2.96e-04229485PF00169
DomainWD40

SCAP DCAF12L1 TEP1 DCAF5 DCAF12

5.19e-04259485PF00400
DomainWD40

SCAP DCAF12L1 TEP1 DCAF5 DCAF12

6.06e-04268485SM00320
DomainWD40_repeat

SCAP DCAF12L1 TEP1 DCAF5 DCAF12

6.48e-04272485IPR001680
DomainPH

RASA1 NET1 PLD1 ARHGEF3 FERMT3

7.15e-04278485SM00233
DomainWD_REPEATS_1

SCAP DCAF12L1 TEP1 DCAF5 DCAF12

7.15e-04278485PS00678
DomainPH_DOMAIN

RASA1 NET1 PLD1 ARHGEF3 FERMT3

7.27e-04279485PS50003
DomainWD_REPEATS_2

SCAP DCAF12L1 TEP1 DCAF5 DCAF12

7.27e-04279485PS50082
DomainWD_REPEATS_REGION

SCAP DCAF12L1 TEP1 DCAF5 DCAF12

7.27e-04279485PS50294
DomainPH_domain

RASA1 NET1 PLD1 ARHGEF3 FERMT3

7.39e-04280485IPR001849
DomainWD40_repeat_dom

SCAP DCAF12L1 TEP1 DCAF5 DCAF12

9.62e-04297485IPR017986
DomainATPase_AAA_CS

KATNA1 FIGNL1

2.51e-0329482IPR003960
Domain-

RASA1 NET1 PLD1 ARHGEF3 FERMT3

3.20e-033914852.30.29.30
DomainAAA

KATNA1 FIGNL1

3.44e-0334482PS00674
DomainGDS_CDC24_CS

NET1 ARHGEF3

4.51e-0339482IPR001331
DomainPH_dom-like

RASA1 NET1 PLD1 ARHGEF3 FERMT3

4.61e-03426485IPR011993
DomainDual-sp_phosphatase_cat-dom

SSH3 TPTE2

4.98e-0341482IPR000340
DomainDSPc

SSH3 TPTE2

4.98e-0341482PF00782
DomainAAA

KATNA1 FIGNL1

7.90e-0352482PF00004
DomainATPase_AAA_core

KATNA1 FIGNL1

8.50e-0354482IPR003959
DomainWD40_repeat_CS

SCAP TEP1 DCAF12

8.61e-03164483IPR019775
Pubmed

The Rho exchange factor Net1 is regulated by nuclear sequestration.

NET1 ARHGEF3

2.11e-06251211839749
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

RPL23A DNAJB12 RPAP1 XPO5 HEATR1 BIRC6 IMMT SLC27A4

4.84e-0665751836180527
Pubmed

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

DCAF12L1 DCAF5 DCAF12

2.23e-053751316949367
Pubmed

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.

DNAJB12 XPO5 SSH3 TPTE2 HEATR1 IMMT DCAF5 SLC27A4

5.88e-0593151827432908
Pubmed

A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.

DCAF5 DCAF12

7.54e-05951219966799
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

RPL23A RPAP1 XPO5 TPTE2 HEATR1 SIX4 IMMT SLC27A4

8.05e-0597451828675297
Pubmed

A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export.

RPL23A XPO5

9.42e-051051221048991
Pubmed

Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation.

NET1 SIX4

1.38e-041251222987639
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

SCAP NET1 HEATR1 PLD1 ARHGEF3 CPT2 HERC4 DCAF5

1.68e-04108451811544199
Pubmed

Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis.

IHH FERMT3

2.19e-041551226151572
Pubmed

alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.

RELN IHH

3.55e-041951216543460
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

DNAJB12 SCAP RPAP1 XPO5 HEATR1 IMMT SLC27A4

4.29e-0494251731073040
Pubmed

Nutrient Transporter Gene Expression in the Early Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy.

CPT2 SLC27A4

6.19e-042551235478964
Pubmed

Array MAPPIT: high-throughput interactome analysis in mammalian cells.

FBXL8 ASB2

6.70e-042651219159283
Pubmed

Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment.

RPL23A XPO5 HEATR1 IMMT FERMT3

7.56e-0449151522623428
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

TMEM106B SCAP PLD1 IMMT SLC27A4

8.50e-0450451534432599
Pubmed

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

DCAF5 DCAF12

1.02e-033251216964240
Pubmed

Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum.

RELN NETO1

1.08e-033351218199763
Pubmed

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.

SSH3 IMMT SLC27A4

1.11e-0313851326752685
Pubmed

Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.

KIF20A BIRC6 SLC27A4

1.13e-0313951325476789
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

CARD10 SIGLEC1 TEP1 BIRC6

1.15e-0331351420800603
Pubmed

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.

KATNA1 DCAF5

1.22e-033551219287380
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

RPL23A DNAJB12 RPAP1 HEATR1 CPT2 BIRC6 FIGNL1 IMMT

1.41e-03149651832877691
GeneFamilyWD repeat domain containing

SCAP DCAF12L1 TEP1 DCAF5 DCAF12

1.21e-04262345362
GeneFamilyWD repeat domain containing|DDB1 and CUL4 associated factors

DCAF5 DCAF12

5.15e-0418342498
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

RASA1 NET1 PLD1 FERMT3

5.81e-04206344682
GeneFamilyAAA ATPases

KATNA1 FIGNL1

4.45e-0353342413
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

NET1 ARHGEF3

6.83e-0366342722
CoexpressionHALLMARK_MITOTIC_SPINDLE

RASA1 NET1 ARHGEF3 KATNA1 PALLD

3.85e-05199505M5893
CoexpressionGSE3039_CD4_TCELL_VS_B1_BCELL_UP

CARD10 ASB2 TEP1 PALLD DKKL1

3.94e-05200505M6466
CoexpressionGSE17721_CTRL_VS_GARDIQUIMOD_1H_BMDC_DN

CARD10 ARHGEF3 NRROS CPT2 FIGNL1

3.94e-05200505M3777
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN RGS7BP CARD10 SLC7A7 DYNLT4

1.20e-06163515c21114826bee1b05b411984326fef6b6e0d05316
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN RGS7BP CARD10 SLC7A7 DYNLT4

1.20e-061635155d49414432db259a19df50d7944581d00b69f537
ToppCellfacs-Pancreas-Exocrine-3m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4B SIGLEC1 NRROS FERMT3

2.49e-05148514bbf4933582b50b3412c805de5ed137107c996236
ToppCellfacs-Pancreas-Exocrine-3m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4B SIGLEC1 NRROS FERMT3

2.49e-051485146543860e3207a7de92a35bb6004be51287582f7a
ToppCellfacs-Pancreas-Exocrine-3m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4B SIGLEC1 NRROS FERMT3

2.49e-0514851479e376503a3f9504a1ec5af4a60a09cc80e19059
ToppCellE18.5-Immune-Immune_Myeloid-DC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND4B TEP1 DKKL1 FERMT3

3.38e-051605149f1fec2cf565193c73cc3c8a4f0476e57478e3b8
ToppCellE18.5-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND4B TEP1 DKKL1 FERMT3

3.55e-05162514388670cf3acef17df971c0d8ae3ce14398945192
ToppCellE18.5-Immune-Immune_Myeloid-DC-cDC1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DENND4B TEP1 DKKL1 FERMT3

3.55e-051625149333d923225df7bfdf6b3a4c32816751315aec50
ToppCellfacs-SCAT-Fat-3m-Myeloid-myeloid_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIGLEC1 NRROS TEP1 FERMT3

3.90e-051665148395c74db8e4e54af97a3f2b75cb75171140ec31
ToppCellfacs-SCAT-Fat-3m-Myeloid|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIGLEC1 NRROS TEP1 FERMT3

3.90e-0516651476807edc5620514b53a14be354b84c54c112b8f9
ToppCellfacs-SCAT-Fat-3m-Myeloid-nan|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIGLEC1 NRROS TEP1 FERMT3

3.90e-05166514645b842b94b8d2f4b26c2623f8589f56bd782c26
ToppCelldroplet-Lung-nan-21m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASB2 NRROS TEP1 DCAF12

4.28e-05170514d72eb77271d61e27a3d247149561c7f45fadb28b
ToppCellfacs-Aorta-Heart-3m-Myeloid|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4B ASB2 FERMT3 DCAF12

4.58e-05173514513b4d31bcfb269556c6b4cc389865fb12e52c4f
ToppCellfacs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP NET1 ASB2 PALLD

4.79e-05175514d8e385320f554d974538b7cdc4f8e4767f1455f2
ToppCellCOVID-mDC1-|COVID / Condition, Cell_class and T cell subcluster

NET1 CARD10 ASB2 IL9R

4.79e-0517551483a95d6fc2ddf3ec53f05825bbc982fb8d2ccd15
ToppCellCOVID-mDC1|COVID / Condition, Cell_class and T cell subcluster

NET1 CARD10 ASB2 IL9R

4.79e-05175514b9280444016e21c28131a61df65cc5c56d402412
ToppCellfacs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP NET1 ASB2 PALLD

4.79e-05175514cf15465855602ba135752c18755e3e058dbd42ec
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-ILC2|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBXL8 NRROS FERMT3 IL9R

5.01e-051775149828504591599619649d41a78daf7c052729c669
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP NET1 ASB2 PALLD

5.23e-051795148da6863edc756540bb097cc7221c1408640d9bb4
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP NET1 ASB2 PALLD

5.23e-05179514f39c13c99a07d009cc677e363ffe089089c64916
ToppCellfacs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP NET1 ASB2 PALLD

5.70e-051835148d45dff06a199b1369576657f7f9dc0249c5f841
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NET1 NETO1 SIGLEC1 FIGNL1

5.70e-0518351442dc31d587fbb9724b2f0be5ee8ed77233f67b86
ToppCellfacs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP NET1 ASB2 PALLD

5.70e-05183514421265fa15d5a028cb567bb0904e670473ef102b
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP ASB2 IHH PALLD

6.33e-0518851461f010c165826b434ca3d27553d4c9e13d2c0c51
ToppCelldroplet-Lung-nan-18m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP ASB2 IHH PALLD

6.33e-051885147553ef7de3575af4cf34704b405b551c1af8eb83
ToppCelldroplet-Tongue-nan-3m-Epithelial-suprabasal_interpapillary|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASB2 HERC4 SLC27A4 FERMT3

6.73e-05191514abdd93b2313e635f75a750d051a6a01ddc4e2df9
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP NET1 ASB2 PALLD

6.87e-05192514eb9a0b3d32f90f8b95905c740aab21639dae5cbd
ToppCellmLN-B_cell-B_cell_cycling|B_cell / Region, Cell class and subclass

NET1 ASB2 PALLD DCAF12

7.58e-051975142071526fe46de8359ea118ff78581eb4454aa55a
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RGS7BP NET1 ASB2 PALLD

7.73e-05198514d1827e3707b929e3a3562989a0c11537d344e164
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CCL|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

RPAP1 SIGLEC1 NRROS SLC7A7

7.89e-0519951452c06fcc112da21b1d914a896c04bde06fc756fe
ToppCellwk_08-11-Hematologic|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SIGLEC1 NRROS SLC7A7 FERMT3

7.89e-05199514edc9afd7be8543cb93a2bb874a14aad0417dfa92
ToppCellwk_08-11-Hematologic-Myeloid-SPP1+_Mac|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SIGLEC1 NRROS SLC7A7 FERMT3

7.89e-05199514d94cf750599366061066074e8007d707adf6fc5a
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid-Dendritic_cells-mDC|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DENND4B SIGLEC1 ASB2 FERMT3

8.04e-05200514f78968d4b4d907094b2c44dcf5ac557ae94e4484
ToppCellwk_08-11-Hematologic-Myeloid|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SIGLEC1 NRROS SLC7A7 FERMT3

8.04e-05200514148e09e27e4a563bdd1fbe9a593cd938885cbb1b

Protein segments in the cluster

PeptideGeneStartEntry
PRSLLVLRGPAYTRL

ALKBH6

166

Q3KRA9
LLILSPLRYKLRMTP

HTR6

126

P50406
LRPYSLVRPLLVSAL

CARD10

831

Q9BWT7
LDIPRSRLVKYPLLL

ARHGEF3

256

Q9NR81
PLVRRTLPVLLLYSI

BIRC6

621

Q9NR09
YRIKLLDTLPLPGRL

ASB2

611

Q96Q27
LDTLPLPGRLIRYLK

ASB2

616

Q96Q27
RLPIPKLEDTIRRYL

CPT2

51

P23786
SLLNLTPYPLVRRRK

RGS7BP

231

Q6MZT1
IRAPPRSKIYLRFLD

NETO1

206

Q8TDF5
RRRVRAILPYTKVPD

RASA1

281

P20936
PRSRLVKYPLLLKEI

NET1

311

Q7Z628
LYIPKRKIISPRSIE

ANKRD36C

406

Q5JPF3
RRRLVKRLYIPLPEA

FIGNL1

556

Q6PIW4
VHVRLRELSPPRYKL

DYNLT4

156

Q5JR98
SPRKTHLLYILRPSR

DKKL1

226

Q9UK85
LKLYKIGIPPSERRI

HERC4

571

Q5GLZ8
TQLLALRRRLPPVLY

DCAF5

246

Q96JK2
KFVLRPLRPCRRYST

IMMT

21

Q16891
KRITVYLPLSTISPR

RELN

1726

P78509
PLLTRPSYIRSLRKA

PALLD

126

Q8WX93
DPVEYTLRKRLPSRL

POP7

16

O75817
RKRLPPVKRSLVYYL

DCAF12

36

Q5T6F0
CPRLRTYTLKLTREP

FBXL8

351

Q96CD0
LTLERPALRYPERLK

C9orf43

266

Q8TAL5
RLYPTPRVRALIESL

DNAJB12

36

Q9NXW2
KLLSPRTLPRRPYKV

DENND4B

506

O75064
RTLPRRPYKVLLATL

DENND4B

511

O75064
RRLEKRIYIPLPSAK

KATNA1

371

O75449
PLLLKRQRRPATYRS

DCAF12L1

36

Q5VU92
LPLIRLLESKYPRTL

HEATR1

426

Q9H583
KRYISLLPVIPVTLR

SCAP

646

Q12770
SRRRPPRKLVPLAYK

IHH

36

Q14623
PLLPQYSKLRTLLLR

NRROS

266

Q86YC3
FLIPVLRSLARRKPT

NUTM2F

236

A1L443
FLIPVLRSLARRKPT

NUTM2G

236

Q5VZR2
LIPYSDQRLRPRRTK

TMEM106B

81

Q9NUM4
LKYKAFIRIPIPTRR

PLD1

131

Q13393
DKYRLRRKFPLPRTI

SIX4

206

Q9UIU6
TLRLRRQPKYPRKSA

RPL23A

51

P62750
PTYLLFKLSPRVKRI

IL9R

286

Q01113
RPPRLRYLLVVSTRE

SSH3

121

Q8TE77
RLLLVKRESGRPLYL

TEP1

1351

Q99973
KELPLYARPIFLRLL

SLC27A4

571

Q6P1M0
KVYLRVRPLLPSELE

KIF20A

66

O95235
IRVPEHKRPLYLRRI

SLC7A7

461

Q9UM01
RDPLLLAIIPKYLRA

XPO5

386

Q9HAV4
IPRRPRKLTLKGYRQ

FERMT3

361

Q86UX7
RAPRLSRPITLDVLY

SIGLEC1

1156

Q9BZZ2
IKGLLATSLLPRLRY

RPAP1

536

Q9BWH6
LPRPLTSLYIRLSIL

ZNF818P

16

Q6ZRF7
PPRRILFIKRFIIYS

TPTE2

391

Q6XPS3
RLRTLEPIPLKLYRN

UBXN11

226

Q5T124