Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncomplement component C3b binding

CFHR1 CFHR2 CFHR5 CFHR4

2.90e-0812574GO:0001851
GeneOntologyMolecularFunctioncomplement binding

CFHR1 CFHR2 CFHR5 CR2 CFHR4

3.01e-0832575GO:0001848
GeneOntologyMolecularFunctionopsonin binding

CFHR1 CFHR2 CFHR5 CFHR4

7.22e-0725574GO:0001846
GeneOntologyMolecularFunctionproteoglycan binding

CTSK CTSV CFHR4

4.17e-0451573GO:0043394
GeneOntologyMolecularFunctionvoltage-gated chloride channel activity

CLCN1 ANO6

4.33e-0411572GO:0005247
GeneOntologyMolecularFunctionlipase activity

PNLIPRP1 ABHD1 PLA2G4E LIPI

6.49e-04138574GO:0016298
GeneOntologyMolecularFunctioncarboxylic ester hydrolase activity

PNLIPRP1 ABHD1 PLA2G4E LIPI

1.05e-03157574GO:0052689
GeneOntologyMolecularFunctionvoltage-gated monoatomic anion channel activity

CLCN1 ANO6

1.06e-0317572GO:0008308
GeneOntologyMolecularFunctionimmunoglobulin receptor binding

TARM1 CR2

1.62e-0321572GO:0034987
GeneOntologyBiologicalProcesscomplement activation

CFHR1 CFHR2 C4BPA CFHR5 CR2 CFHR4

3.89e-0870576GO:0006956
GeneOntologyBiologicalProcesscytolysis by host of symbiont cells

CFHR1 CFHR2 CFHR5

2.37e-0610573GO:0051838
GeneOntologyBiologicalProcesshumoral immune response

CFHR1 CFHR2 C4BPA CFHR5 CR2 TF IGKV3-20 CFHR4

2.69e-06321578GO:0006959
GeneOntologyBiologicalProcesscomplement activation, alternative pathway

CFHR5 CR2 CFHR4

1.88e-0519573GO:0006957
GeneOntologyBiologicalProcessregulation of complement activation

C4BPA CR2 CFHR4

5.58e-0527573GO:0030449
GeneOntologyBiologicalProcesskilling by host of symbiont cells

CFHR1 CFHR2 CFHR5

1.58e-0438573GO:0051873
GeneOntologyBiologicalProcessnegative regulation of complement activation, classical pathway

C4BPA CR2

2.08e-048572GO:0045959
GeneOntologyCellularComponentIgM immunoglobulin complex, circulating

IGKV3D-20 IGKV3-20

2.17e-048592GO:0071754
GeneOntologyCellularComponentpentameric IgM immunoglobulin complex

IGKV3D-20 IGKV3-20

2.17e-048592GO:0071756
GeneOntologyCellularComponentmonomeric IgA immunoglobulin complex

IGKV3D-20 IGKV3-20

2.78e-049592GO:0071748
GeneOntologyCellularComponentpolymeric IgA immunoglobulin complex

IGKV3D-20 IGKV3-20

3.47e-0410592GO:0071749
GeneOntologyCellularComponentIgA immunoglobulin complex, circulating

IGKV3D-20 IGKV3-20

3.47e-0410592GO:0071746
GeneOntologyCellularComponentsecretory IgA immunoglobulin complex

IGKV3D-20 IGKV3-20

3.47e-0410592GO:0071751
GeneOntologyCellularComponentblood microparticle

CFHR1 C4BPA TF IGKV3-20

7.33e-04144594GO:0072562
GeneOntologyCellularComponentIgA immunoglobulin complex

IGKV3D-20 IGKV3-20

8.03e-0415592GO:0071745
GeneOntologyCellularComponentIgM immunoglobulin complex

IGKV3D-20 IGKV3-20

8.03e-0415592GO:0071753
GeneOntologyCellularComponentimmunoglobulin complex, circulating

IGKV3D-20 IGKV3-20

1.04e-0317592GO:0042571
GeneOntologyCellularComponentlysosomal lumen

HYAL1 CTSK CTSV

2.69e-0398593GO:0043202
GeneOntologyCellularComponentendolysosome

MPEG1 CTSK

3.24e-0330592GO:0036019
DomainSushi

CFHR1 CFHR2 C4BPA CFHR5 CR2 CFHR4

9.03e-0952556PF00084
DomainCCP

CFHR1 CFHR2 C4BPA CFHR5 CR2 CFHR4

1.14e-0854556SM00032
DomainSUSHI

CFHR1 CFHR2 C4BPA CFHR5 CR2 CFHR4

1.43e-0856556PS50923
DomainSushi_SCR_CCP_dom

CFHR1 CFHR2 C4BPA CFHR5 CR2 CFHR4

1.59e-0857556IPR000436
DomainInhibitor_I29

CTSK CTSV

1.77e-047552PF08246
DomainProt_inhib_I29

CTSK CTSV

1.77e-047552IPR013201
DomainInhibitor_I29

CTSK CTSV

1.77e-047552SM00848
DomainPept_asp_AS

CTSK CTSV

3.77e-0410552IPR025661
DomainLipase_LIPH

PNLIPRP1 LIPI

3.77e-0410552IPR016272
DomainLipase

PNLIPRP1 LIPI

3.77e-0410552PF00151
DomainLipase_N

PNLIPRP1 LIPI

3.77e-0410552IPR033906
DomainLipase/vitellogenin

PNLIPRP1 LIPI

3.77e-0410552IPR013818
DomainTAG_lipase

PNLIPRP1 LIPI

3.77e-0410552IPR000734
DomainPept_his_AS

CTSK CTSV

4.60e-0411552IPR025660
DomainPept_C1

CTSK CTSV

6.50e-0413552SM00645
DomainPeptidase_C1A_C

CTSK CTSV

6.50e-0413552IPR000668
DomainPeptidase_C1

CTSK CTSV

6.50e-0413552PF00112
DomainPeptidase_C1A

CTSK CTSV

6.50e-0413552IPR013128
DomainLIPASE_SER

PNLIPRP1 LIPI

2.64e-0326552PS00120
DomainTHIOL_PROTEASE_CYS

CTSK CTSV

2.64e-0326552PS00139
DomainTHIOL_PROTEASE_ASN

CTSK CTSV

2.85e-0327552PS00640
DomainTHIOL_PROTEASE_HIS

CTSK CTSV

2.85e-0327552PS00639
DomainPept_cys_AS

CTSK CTSV

3.06e-0328552IPR000169
Domain-

PNLIPRP1 ABHD1 LIPI

5.20e-031195533.40.50.1820
DomainAB_hydrolase

PNLIPRP1 ABHD1 LIPI

5.20e-03119553IPR029058
Domain-

UNK UNKL

6.18e-03405524.10.1000.10
Domain-

HYAL1 ALAD

6.80e-03425523.20.20.70
DomainAldolase_TIM

HYAL1 ALAD

7.44e-0344552IPR013785
DomainZnF_C3H1

UNK UNKL

8.81e-0348552SM00356
Domainzf-CCCH

UNK UNKL

9.16e-0349552PF00642
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR

CFHR1 CFHR2 CFHR5 CFHR4

1.23e-096444M47880
PathwayREACTOME_COMPLEMENT_CASCADE

CFHR1 CFHR2 IGKV3D-20 C4BPA CFHR5 CR2 IGKV3-20 CFHR4

2.13e-09115448M19752
PathwayREACTOME_INNATE_IMMUNE_SYSTEM

CFHR1 CFHR2 TARM1 ANO6 ITLN1 IGKV3D-20 C4BPA ALAD CFHR5 CR2 MAP2K1 CTSK CTSV IGKV3-20 CFHR4

8.06e-0711284415M1036
PathwayREACTOME_COMPLEMENT_CASCADE

CFHR1 CFHR2 CR2 CFHR4

1.33e-0484444MM14653
PathwayWP_COMPLEMENT_SYSTEM

CFHR2 C4BPA CR2 CFHR4

2.23e-0496444M39581
PathwayREACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_KERATINOCYTES

CTSK CTSV

2.63e-048442M27796
Pubmed

Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.

CFHR1 CFHR2 C4BPA CFHR5 CFHR4

1.36e-12958520059470
Pubmed

Factor H-related proteins determine complement-activating surfaces.

CFHR1 CFHR2 CFHR5 CFHR4

3.48e-11558425979655
Pubmed

Dimerization of complement factor H-related proteins modulates complement activation in vivo.

CFHR1 CFHR2 CFHR5 CFHR4

1.04e-10658423487775
Pubmed

Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.

CFHR1 CFHR2 CFHR5 CFHR4

1.04e-10658427196323
Pubmed

Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.

CFHR1 CFHR2 CFHR5 CFHR4

1.04e-10658417438673
Pubmed

Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.

CFHR1 C4BPA CFHR5 C1QTNF7 CR2

1.78e-093158519344414
Pubmed

C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.

CFHR1 CFHR2 CFHR5

4.40e-09358323728178
Pubmed

Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1.

C4BPA CR2 CFHR4

4.39e-0855839799332
Pubmed

Identification and sequence analysis of four complement factor H-related transcripts in mouse liver.

CFHR1 CFHR2 CFHR4

4.39e-0855831689298
Pubmed

A radiation hybrid map of complement factor H and factor H-related genes.

CFHR1 CFHR2 CFHR4

4.39e-08558310380701
Pubmed

The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.

CFHR2 CFHR5 CFHR4

8.77e-08658318541031
Pubmed

Genetic organization of complement receptor-related genes in the mouse.

C4BPA CR2 CFHR4

2.45e-0785832564419
Pubmed

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.

CFHR1 CFHR5 CFHR4

3.67e-07958328533443
Pubmed

Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced Alternative Complement Pathway.

CFHR1 CFHR2

2.73e-06258232636836
Pubmed

Circulating complement factor H-related proteins 1 and 5 correlate with disease activity in IgA nephropathy.

CFHR1 CFHR5

2.73e-06258228673452
Pubmed

The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein.

UNK UNKL

2.73e-0625821339381
Pubmed

Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration.

CFHR2 CFHR5

2.73e-06258234260947
Pubmed

Molecular cloning of a human serum protein structurally related to complement factor H.

CFHR1 CFHR2

2.73e-0625821711047
Pubmed

A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.

CFHR1 CFHR5

2.73e-06258228729035
Pubmed

Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes.

CR2 TF

2.73e-06258226623655
Pubmed

Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation.

CTSK CTSV

2.73e-06258222562303
Pubmed

Molecular bases for the association of FHR-1 with atypical hemolytic uremic syndrome and other diseases.

CFHR1 CFHR2

2.73e-06258233651882
Pubmed

Complement factor H-related hybrid protein deregulates complement in dense deposit disease.

CFHR2 CFHR5

2.73e-06258224334459
Pubmed

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation.

CFHR1 CFHR5

2.73e-06258235392081
Pubmed

Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells.

CTSK CTSV

2.73e-06258224719048
Pubmed

Genome-wide association study identifies susceptibility loci for IgA nephropathy.

CFHR1 CFHR5 CFHR4

4.18e-061958321399633
Pubmed

Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.

CR2 CFHR4

8.19e-06358219828624
Pubmed

[Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production].

IGKV3D-20 IGKV3-20

8.19e-0635825027703
Pubmed

Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts.

CTSK CTSV

8.19e-06358222126332
Pubmed

Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption.

CTSK CTSV

8.19e-06358219028686
Pubmed

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies.

CFHR1 CFHR2

8.19e-06358231273197
Pubmed

Sequential, but not Concurrent, Incubation of Cathepsin K and L with Type I Collagen Results in Extended Proteolysis.

CTSK CTSV

8.19e-06358230931961
Pubmed

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.

CFHR1 CFHR4

8.19e-06358221637784
Pubmed

Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis.

CTSK CTSV

8.19e-06358223871919
Pubmed

An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury.

CTSK CTSV

8.19e-06358217889653
Pubmed

Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH/CFHR1-3 and complement factor H 479.

CFHR1 CFHR2

1.64e-05458224333077
Pubmed

Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation.

CTSK CTSV

1.64e-05458232007579
Pubmed

CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome.

CFHR1 CFHR4

1.64e-05458236793547
Pubmed

Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone.

CTSK CTSV

1.64e-05458216939398
Pubmed

Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis.

CTSK CTSV

1.64e-05458217068745
Pubmed

Lack of cathepsin activities alter or prevent the development of lung granulomas in a mouse model of sarcoidosis.

CTSK CTSV

1.64e-05458221251246
Pubmed

Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry.

C4BPA TF IGKV3-20

2.11e-053258323750785
Pubmed

Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation.

STK3 MAP2K1

2.72e-05558220212043
Pubmed

Complement factor H and related proteins: an expanding family of complement-regulatory proteins?

CFHR1 CFHR2

2.72e-0555828172644
Pubmed

Cathepsin V, but not cathepsins L, B and K, may release angiostatin-like fragments from plasminogen.

CTSK CTSV

2.72e-05558218163891
Pubmed

Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V.

CTSK CTSV

2.72e-05558233786919
Pubmed

Thyroid functions of mouse cathepsins B, K, and L.

CTSK CTSV

2.72e-05558212782676
Pubmed

Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation.

CR2 CFHR4

2.72e-05558220962256
Pubmed

Primary structures of N-terminal extra peptide segments linked to the variable and constant regions of immunoglobulin light chain precursors: implications on the organization and controlled expression of immunoglobulin genes.

IGKV3D-20 IGKV3-20

4.08e-05658298179
Pubmed

Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P.

CTSK CTSV

4.08e-05658210760593
Pubmed

Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions.

IGKV3D-20 IGKV3-20

4.08e-05658299744
Pubmed

The human VK locus. Characterization of a duplicated region encoding 28 different immunoglobulin genes.

IGKV3D-20 IGKV3-20

4.08e-0565823351922
Pubmed

Mouse immunoglobulin chains. Pattern of sequence variation among kappa chains with limited sequence differences.

IGKV3D-20 IGKV3-20

4.08e-0565824691517
Pubmed

The 3' part of the immunoglobulin kappa locus of the mouse.

IGKV3D-20 IGKV3-20

5.71e-0575829603450
Pubmed

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.

CFHR1 CFHR4

5.71e-05758219861685
Pubmed

C3 Glomerulopathy

CFHR1 CFHR5

7.60e-05858220301598
Pubmed

Lysosomal processing of progranulin.

CTSK CTSV

7.60e-05858228835281
Pubmed

Asparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activation.

CTSK CTSV

7.60e-05858222916010
Pubmed

STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.

STK3 STK25

9.77e-05958234518307
Pubmed

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.

CFHR1 C4BPA TF IGKV3-20

9.78e-0514358422516433
Pubmed

A molecular genetic approach to gld "autoimmune" disease.

C4BPA CFHR4

1.22e-04105823416634
Pubmed

Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity.

STK3 STK25

1.22e-041058220949042
Pubmed

Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.

C4BPA TF CFHR4

1.34e-045958317330941
Pubmed

Genetic Atypical Hemolytic-Uremic Syndrome

CFHR1 CFHR4

1.49e-041158220301541
Pubmed

Ischemic stroke is associated with the ABO locus: the EuroCLOT study.

CFHR5 CFHR4

2.46e-041458223381943
Pubmed

Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.

CFHR5 CFHR4

2.46e-041458223577725
Pubmed

The zinc finger/RING domain protein Unkempt regulates cognitive flexibility.

UNK UNKL

2.83e-041558234381067
Pubmed

Genetic influences on the end-stage effector phase of arthritis.

C4BPA CFHR4

3.23e-041658211489951
Pubmed

Maternal UHRF1 Is Essential for Transcription Landscapes and Repression of Repetitive Elements During the Maternal-to-Zygotic Transition.

CNOT6L UNK

3.66e-041758233634103
Pubmed

Genome cross-referencing and XREFdb: implications for the identification and analysis of genes mutated in human disease.

GK CLCN1

4.11e-04185829090377
Pubmed

Identification of transcripts with enriched expression in the developing and adult pancreas.

CNOT6L PNLIPRP1 ZNF473 PLXNB2 TF CFHR4

5.97e-0462458618554416
Pubmed

Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.

CR2 CFHR4

7.37e-042458211739537
Pubmed

Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences.

GK CLCN1

8.00e-04255828889551
Pubmed

Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1.

C4BPA CFHR4

9.34e-04275822574151
Pubmed

Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.

C4BPA CR2

1.31e-033258218842294
Pubmed

Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.

C4BPA CFHR4

1.66e-03365827558020
Cytoband1q32

CFHR1 C4BPA CR2 CFHR4

4.99e-07495941q32
CytobandEnsembl 112 genes in cytogenetic band chr1q31

CFHR1 CFHR2 CFHR5 CFHR4

2.79e-0675594chr1q31
Cytoband1q31.3

CFHR2 CFHR5

1.93e-04165921q31.3
CytobandEnsembl 112 genes in cytogenetic band chr9q32

ZNF618 ALAD

1.91e-0350592chr9q32
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CFHR1 CFHR2 C4BPA CFHR5 CR2 CFHR4

4.17e-09574361179
GeneFamilyComplement system|Sushi domain containing

CFHR1 CFHR2 CFHR5 CR2 CFHR4

2.14e-0836435492
GeneFamilyCathepsins

CTSK CTSV

5.69e-0415432470
GeneFamilyZinc fingers CCCH-type

UNK UNKL

3.13e-033543273
CoexpressionSTK33_SKM_UP

FAM20C LPAR6 MPEG1 UNK UNKL PLXNB2 CTSK

2.72e-06279587M2857
CoexpressionLEE_LIVER_CANCER_MYC_E2F1_DN

CFHR1 PNLIPRP1 C4BPA ALAD

1.24e-0564584M5636
CoexpressionNABA_MATRISOME

FAM20C OTOGL HYAL1 ITLN1 C4BPA C1QTNF7 PLXNB2 MUC2 CTSK CTSV

6.59e-0510085810MM17056
CoexpressionGSE22342_CD11C_HIGH_VS_LOW_DECIDUAL_MACROPHAGES_DN

GID4 HYAL1 UNKL MUC2 CFHR4

7.20e-05195585M8132
CoexpressionGSE34156_NOD2_LIGAND_VS_TLR1_TLR2_LIGAND_6H_TREATED_MONOCYTE_DN

FAM20C GK ANO6 MPEG1 PLXNB2

7.56e-05197585M8686
CoexpressionGSE24142_DN2_VS_DN3_THYMOCYTE_FETAL_UP

GK PLXNB2 CTSK TF DYRK3

8.12e-05200585M4574
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Bcl11b-Inhibitory_Gad1Gad2_Id2.Bcl11b_(Interneuron,_Neurogliaform2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

ZNF473 OTOGL CR2 MUC2

2.04e-0668594cfd75c373e10b3761666ccd445ba74755efeb95f
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Bcl11b|Hippocampus / BrainAtlas - Mouse McCarroll V32

ZNF473 OTOGL CR2 MUC2

2.04e-0668594c25fb921dc83eecdc337353894829ae6b5192353
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Bcl11b-Inhibitory_Gad1Gad2_Id2.Bcl11b_(Interneuron,_Neurogliaform2)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

ZNF473 OTOGL CR2 MUC2

2.04e-0668594712f5f4d3a1e0c0db1a340332876206b93bdac31
ToppCellTCGA-Liver|World / Sample_Type by Project: Shred V9

CFHR1 CFHR2 CFHR5 TF CFHR4

3.45e-06174595452932f08cf53e5949672a025d78cecb874aa4b0
ToppCellTCGA-Colorectal-Recurrent_Tumor|TCGA-Colorectal / Sample_Type by Project: Shred V9

CFHR1 CFHR2 CFHR5 TF CFHR4

3.55e-061755957f74961436f88c0e380819095e6104489914d765
ToppCellTCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

CFHR1 CFHR2 CFHR5 TF CFHR4

3.55e-06175595bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CFHR1 CFHR2 C4BPA CFHR5 TF

4.91e-06187595edb0ab0154542b1c0b3a2c216c4a60f0f06290b3
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CFHR1 CFHR2 C4BPA CFHR5 TF

5.17e-061895957899af78b273d9c7f029d52f7e0cf6df4da41f5e
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CFHR1 CFHR2 C4BPA CFHR5 TF

5.30e-06190595a34293601aefe5fb5c400c14091294b9ddaa195b
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FAM20C OTOF MPEG1 PLXNB2 PLPPR2

6.32e-06197595280804810041783f1b7704914b62ffefbb0d88f6
ToppCellmLN-T_cell-Tfh|T_cell / Region, Cell class and subclass

CNOT6L PPP1R3B LPAR6 NOL10 FRMD4B

6.64e-06199595a234f14ff46a0dc2f916a80e1e7af7d793006050
ToppCellControl-Myeloid-Dendritic_cells-pDC|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MPEG1 CR2 DYRK3 SP140

4.10e-05145594bab85a72142b6257f7d424e5301f65b6dcdf745d
ToppCell10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-MAIT|GI_small-bowel / Manually curated celltypes from each tissue

CFHR1 CFHR2 C4BPA CFHR4

4.22e-051465941cb2e157222631e8915d89b255a843d16d7d99cc
ToppCellControl-Myeloid-MoAM2,_CCL18|Control / Condition, Lineage and Cell class

FAM20C ZNF618 LPAR6 CTSK

8.33e-051745944c64ff5666812fb4efa440ba4faeca51d916d68e
ToppCellB_cells-pDCs|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

MPEG1 PLXNB2 CTSV FRMD4B

8.71e-05176594ce757de9e09a225f3f96433f103f43619b0e0dda
ToppCellControl-Myeloid-MoAM2,_CCL18|Myeloid / Condition, Lineage and Cell class

FAM20C ZNF618 LPAR6 CTSK

8.90e-05177594470f54fe2b21c7350ea471e02039461a3808f700
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV3D-20 CR2 IGKV3-20 SP140

9.10e-05178594107dae8b00c4257697a63700e72bb434cdb8406f
ToppCell10x5'v1-week_17-19-Myeloid_macrophage-stroma-monocytoid_macrophage|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CFHR1 FAM20C LPAR6 CACNA1G

9.50e-05180594ba4c1fb55e8f1095bea6968417fefcf5f700926b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

FAM20C GK C1QTNF7 FRMD4B

9.70e-05181594c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCellcellseq-Mesenchymal-Chondrocytic-Mesenchymal_Airway/Vascular|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

UNKL CACNA1G C1QTNF7 CTSK

9.91e-05182594bb7de0c93d8f59f13c990e425139b9348ca8027e
ToppCellcellseq-Mesenchymal-Chondrocytic-Mesenchymal_Airway/Vascular-Chondrocyte|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

UNKL CACNA1G C1QTNF7 CTSK

9.91e-05182594507f095af4dff60f2c2b64d750477154084c3595
ToppCellcellseq-Mesenchymal-Chondrocytic|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

UNKL CACNA1G C1QTNF7 CTSK

9.91e-0518259488bd17c07bd8443a0ede4e9dc7bc9d1230b42211
ToppCellwk_15-18-Hematologic_Lymphocytic-B-CD5+_CCL22-_mature_B|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

IGKV3D-20 CR2 IGKV3-20 SP140

1.03e-0418459418aa9c43b79d12c9e420dfd9822745c022be6789
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFHR1 C1QTNF7 PLXNB2 CTSK

1.06e-04185594eaa54b76743628c89b4310be57b87fa92b75fd37
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFHR1 C1QTNF7 PLXNB2 CTSK

1.06e-04185594f7f4c921d248c637351e2e882589b99ba7f04b66
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFHR1 C1QTNF7 PLXNB2 CTSK

1.06e-04185594ff38a15af3dec36d9993f06623591872b5d1da9a
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TARM1 GK MPEG1 PLXNB2

1.17e-04190594e1c02fe6fa43a36381cb9f02569fa9b1c5f5efdc
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FAM20C MPEG1 PLXNB2 PLPPR2

1.17e-041905944b9bac17eb7ceadada932f2d4a20a5f176088d53
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TARM1 GK MPEG1 PLXNB2

1.17e-041905946de15ec88426fbf52acb0a8371f82cf03b6a6237
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FAM20C MPEG1 PLXNB2 PLPPR2

1.24e-0419359445205ad1ef12aabf33059a7ff922a3bb86994c2f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FAM20C MPEG1 PLXNB2 PLPPR2

1.24e-041935941beca3d3b34082b7d9112fbd094bee8019921ca0
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FAM20C MPEG1 PLXNB2 PLPPR2

1.24e-041935942ebb950476767f330241b0077ced22e55e124359
ToppCelldistal-Hematologic-EREG+_Dendritic-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GK PPP1R3B MPEG1 MAP2K1

1.32e-04196594c17bb7b3992bfec194bfa310f201a5c64b35868e
ToppCellMonocytes-IL1B+_Monocytes|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

GK LPAR6 MPEG1 FRMD4B

1.32e-041965947bc0735d324ac5a1661434cda4116ddd58296730
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV3D-20 CR2 IGKV3-20 SP140

1.34e-041975942662138671262b30508c5759038bcdcfe6551696
ToppCellILEUM-inflamed-(5)_Plasma-(5)_IgG_plasma_cells|(5)_Plasma / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TMEM147 IGKV3D-20 CTSK IGKV3-20

1.34e-041975946b0941883e40bd82c65659b97a4752e8e32ac190
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV3D-20 CR2 IGKV3-20 SP140

1.34e-041975940e56255862fed099e771ebd2529393dc5a3641ba
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_cell-B_mature|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV3D-20 CR2 IGKV3-20 SP140

1.34e-04197594da175e66d0a743a1b91d46f224b5ff1d37aa5410
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-myeloid_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FAM20C PNLIPRP1 LPAR6 MPEG1

1.34e-041975949838dbd1623babf8de7e9126a28fe5d3666bce42
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_cell-B_naive|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV3D-20 CR2 IGKV3-20 SP140

1.37e-0419859479c690d21d3420d0bb1a3b3b4ea2c9aa3810a219
ToppCellIPF-Myeloid-Macrophage|Myeloid / Disease state, Lineage and Cell class

FAM20C GK CTSK FRMD4B

1.40e-041995943c2b362d5e824e1a04830e70352f8818de984174
ToppCellmild_COVID-19_(asymptomatic)-Classical_Monocyte|World / disease group, cell group and cell class (v2)

FAM20C OTOF MPEG1 PLXNB2

1.40e-04199594727122b6f4ca265d2826c9271b10a4215a9d45a3
ToppCell(1)_T_cell-(16)_Tfh|(1)_T_cell / shred on Cell_type and subtype

PPP1R3B LPAR6 NOL10 FRMD4B

1.42e-042005943b28137e8e69b98fde9f6ab8320cb4d1c3543ef9
ComputationalGenes in the cancer module 58.

CFHR1 C4BPA CR2

3.07e-0521323MODULE_58
ComputationalComplement.

CFHR1 C4BPA CR2

4.08e-0523323MODULE_130
Drug3-Amino-5-Phenylpentane

CTSK CTSV

6.38e-062582DB02869
DrugAC1L9IGO

CFHR1 C4BPA CFHR5 CR2 MAP2K1 CFHR4

7.33e-06184586CID000445722
DrugEtodolac [41340-25-4]; Up 200; 14uM; PC3; HT_HG-U133A

ZNF609 OSBPL3 UNKL ELSPBP1 FRMD4B DYRK3

1.08e-051975862091_UP
DiseaseComplement deficiency disease

CFHR1 CFHR2 CFHR5 CFHR4

4.57e-0733564C0272242
DiseaseC3 glomerulopathy

CFHR1 CFHR2 CFHR5

5.39e-079563C4087273
Diseasehemopexin measurement

CFHR1 CFHR5 CFHR4

1.06e-0611563EFO_0008149
Diseasecomplement factor H-related protein 5 measurement

CFHR1 CFHR2 CFHR5 CFHR4

1.23e-0642564EFO_0008098
Diseasecomplement factor H-related protein 4 measurement

CFHR1 CFHR2 CFHR5 CFHR4

2.31e-0649564EFO_0600091
Diseasezinc finger protein 329 measurement

CFHR1 CFHR4

3.54e-062562EFO_0803276
Diseaseleucine-rich repeat-containing protein 19 measurement

CFHR1 CFHR4

3.54e-062562EFO_0801762
DiseaseCFHR5 DEFICIENCY

CFHR1 CFHR5

3.54e-062562C3553720
Diseasephosphopantothenoylcysteine decarboxylase measurement

CFHR1 CFHR4

3.54e-062562EFO_0802867
Diseaselevel of otoraplin in blood serum

CFHR1 CFHR4

3.54e-062562OBA_2042720
Diseaseprotein FAM209B measurement

CFHR1 CFHR4

3.54e-062562EFO_0802943
Diseasecomplement factor H-related protein 1 measurement

CFHR1 CFHR2 CFHR5 CFHR4

3.97e-0656564EFO_0600054
Diseaselevel of alpha-N-acetylglucosaminidase in blood serum

CFHR1 CFHR4

1.06e-053562OBA_2042500
Diseasesoluble transferrin receptor measurement

CFHR1 CFHR4

1.06e-053562EFO_0004460
Diseasecalnexin measurement

CFHR1 CFHR4

1.06e-053562EFO_0801444
Diseasehistone-lysine N-methyltransferase 2D measurement

CFHR1 CFHR4

1.06e-053562EFO_0801683
Diseasecomplement factor H-related protein 4A measurement

CFHR1 CFHR4

1.06e-053562EFO_0600057
DiseaseNADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement

CFHR1 CFHR4

2.12e-054562EFO_0803292
Diseasekallikrein-5 measurement

CFHR1 CFHR4

2.12e-054562EFO_0020515
Diseasecomplement factor H-related protein 2 measurement

CFHR1 CFHR2 CFHR4

2.28e-0529563EFO_0600055
DiseaseAge related macular degeneration

CFHR1 CFHR2 CFHR4

2.53e-0530563C0242383
Diseasecomplement C1s subcomponent measurement

CFHR1 CFHR4

5.28e-056562EFO_0008091
Diseasecomplement factor H measurement

CFHR1 CFHR2 CFHR4

6.56e-0541563EFO_0008097
DiseaseDNA repair protein XRCC4 measurement

CFHR1 CFHR4

9.83e-058562EFO_0801532
DiseaseHemolytic-uremic syndrome

CFHR1 CFHR4

1.26e-049562cv:C0019061
Diseaseleukocyte immunoglobulin-like receptor subfamily A member 5 measurement

CFHR1 CFHR4

1.26e-049562EFO_0801766
DiseaseAtypical hemolytic-uremic syndrome

CFHR1 CFHR4

1.26e-049562cv:C2931788
Diseaseatrophic macular degeneration, age-related macular degeneration, wet macular degeneration

CFHR1 CFHR5 CFHR4

2.05e-0460563EFO_0001365, EFO_0004683, EFO_1001492
Diseasecomplement factor H-related protein 3 measurement

CFHR1 CFHR2 CFHR5 CFHR4

3.02e-04169564EFO_0600056
Diseaseotitis media (biomarker_via_orthology)

CTSK CTSV

4.72e-0417562DOID:10754 (biomarker_via_orthology)
Diseaseage-related macular degeneration

CFHR1 CFHR5 CFHR4

6.55e-0489563EFO_0001365
Diseasecoagulation factor measurement

CFHR5 CFHR4

6.58e-0420562EFO_0004634

Protein segments in the cluster

PeptideGeneStartEntry
FQFYSKGVYYDESCN

CTSK

256

P43235
NFYAYGFSVTYSCDP

C4BPA

191

P04003
SFQFYKSGIYFEPDC

CTSV

256

O60911
CNSPYIVGFYGAFYS

MAP2K1

121

Q02750
TAVKRYYTFNTYPGC

MPEG1

336

Q2M385
YYTFNTYPGCTDLNS

MPEG1

341

Q2M385
NKSISYYGCALQFYF

OR5I1

91

Q13606
NYYSSCFYIAFFKGK

ANO6

561

Q4KMQ2
YDFGDAQKTASYYSP

ITLN1

211

Q8WWA0
DPSTGCYMYYFQYLS

KMT5A

306

Q9NQR1
PEDFAVYYCQQYGSS

IGKV3D-20

101

A0A0C4DH25
YPGRFDYVFYVSCKE

NLRP10

196

Q86W26
YSAKFASCFYGPFRD

ALAD

196

P13716
GNIFLTSYQYPFYDC

PLXNB2

601

O15031
DGFAAYPCTSYKSFE

PNLIPRP1

296

P54315
TFDGLYYSYQGNCTY

MUC2

4491

Q02817
PTGEVFYYSCEYNFV

CFHR2

46

P36980
FYYSCEYNFVSPSKS

CFHR2

51

P36980
YNDSFKYTLYGCMFS

LPAR6

11

P43657
SYHYPSCDLYFVGAS

NOL10

141

Q9BSC4
KYCFPYFGCRFSSIY

PTTG1IP2

76

P0DTF9
TQGFFCYDSTYAKPY

PLPPR2

46

Q96GM1
GASFAGFYYICFQKS

GID4

251

Q8IVV7
FQTAACFHYPKYFQS

PLA2G4E

256

Q3MJ16
AMFESLFSYYNQYCP

GAL3ST3

156

Q96A11
SSSYYIAGYTPYAEC

FRMD4B

801

Q9Y2L6
FYNDTVTFKCYSGFT

CR2

621

P20023
SEAQCKPYYSDYSRF

CACNA1G

1586

O43497
SPANNICFYGECSYY

FAM20C

356

Q8IXL6
SYGCYFVPAFSGLYA

GK

361

P32189
SYSYYCDQNFVTPSG

CFHR4

51

Q92496
FPVATGQSYSYYCDQ

CFHR4

291

Q92496
PTGEVFYYSCEYNFV

CFHR5

46

Q9BXR6
FYYSCEYNFVSPSKS

CFHR5

51

Q9BXR6
FPFTYKGSVYFTCTH

ELSPBP1

31

Q96BH3
PEDFAVYYCQQYGSS

IGKV3-20

101

P01619
FYGFPDCYNYDFLSP

HYAL1

201

Q12794
PTGEVFYYSCEYNFV

CFHR1

46

Q03591
FYYSCEYNFVSPSKS

CFHR1

51

Q03591
ICAFPGIYYFSYDIT

C1QTNF7

186

Q9BXJ2
FGSSCFEYQKLYTYI

DYRK3

356

O43781
FETFDGIYYYFPGNC

OTOGL

131

Q3ZCN5
STNCPYYNEYFVFDF

OTOF

291

Q9HC10
SAYASSYYRAGSKPF

OSBPL3

591

Q9H4L5
SYTDFPCQYVKDTYA

PPP1R3B

171

Q86XI6
YFVGGQSYNCPYSTT

GMNC

11

A6NCL1
LDTSGTYPFCTYYFV

LIPI

326

Q6XZB0
YTDPLKFYATSYCTA

PPP1R32

21

Q7Z5V6
PSTNLYFADFYCMYT

PHYHIP

216

Q92561
SQCDSPYITRYFGSY

STK25

71

O00506
FGYQDCVTYYKAASP

ABHD1

296

Q96SE0
SVFCGVYEQPYYYSD

CLCN1

251

P35523
PYTNYTFDFKGVIDY

CNOT6L

476

Q96LI5
QCDSPYVVKYYGSYF

STK3

76

Q13188
YTCEFCGKQYKYYTP

ZNF618

256

Q5T7W0
AEFYGSKEDPQTFYY

TF

101

P02787
GFTRLSSSPCYYFYQ

RNF10

496

Q8N5U6
SSSPCYYFYQAEDGQ

RNF10

501

Q8N5U6
SKDSPYYQGFESYYS

ZNF609

886

O15014
GTFNYSPDVYCSKYN

UNKL

71

Q9H9P5
YCCSESSFFAKIPYY

SP140

771

Q13342
EYGNTCSFYKDFNVY

ZNF529

231

Q6P280
ALAYFPYFITYKCSG

TMEM147

11

Q9BVK8
TFNYSPDVYCTKYDE

UNK

81

Q9C0B0
AGNYSCMYYQTKSPF

TARM1

191

B6A8C7
GYKFYVCNEYGTTFS

ZNF473

261

Q8WTR7