Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ribosomal protein S6 kinase activity	RPS6KA1 RPS6KA2 RPS6KA3	2.14e-06	7	80	3	GO:0004711
GeneOntologyCellularComponent	eukaryotic translation initiation factor 2 complex	EIF2S3 EIF2S3B	2.09e-04	6	79	2	GO:0005850
GeneOntologyCellularComponent	proteasome core complex, alpha-subunit complex	PSMA1 PSMA2	3.89e-04	8	79	2	GO:0019773
GeneOntologyCellularComponent	cardiac myofibril	CRYAB MYBPC3	4.99e-04	9	79	2	GO:0097512
GeneOntologyCellularComponent	apical plasma membrane	FAT1 KL ATP7A PRKAA1 PKHD1 ANO1 ABCC2 PFKM	5.02e-04	487	79	8	GO:0016324
MousePheno	dilated pulmonary alveolar duct	KL ATP7A TLR4	2.47e-06	7	59	3	MP:0010908
MousePheno	abnormal pulmonary alveolar duct morphology	KL ATP7A TLR4	1.98e-05	13	59	3	MP:0002271
MousePheno	wide ribs	KL ATP7A	5.24e-05	3	59	2	MP:0004676
MousePheno	decreased hormone level	CDKN2C GUF1 KL ATP7A AZIN2 CYP17A1 RPS6KA3 TLR4 STEAP4 ZFHX3 PFKM	5.96e-05	635	59	11	MP:0014455
Domain	Ribosomal_S6_kinase_II	RPS6KA1 RPS6KA2 RPS6KA3	1.39e-06	6	78	3	IPR016239
Domain	Proteasome_suA-type	PSMA1 PSMA2	4.74e-04	8	78	2	IPR023332
Domain	Proteasome_asu_N	PSMA1 PSMA2	4.74e-04	8	78	2	IPR000426
Domain	Proteasome_A_N	PSMA1 PSMA2	4.74e-04	8	78	2	SM00948
Domain	Proteasome_A_N	PSMA1 PSMA2	4.74e-04	8	78	2	PF10584
Domain	PROTEASOME_ALPHA_2	PSMA1 PSMA2	4.74e-04	8	78	2	PS51475
Domain	PROTEASOME_ALPHA_1	PSMA1 PSMA2	4.74e-04	8	78	2	PS00388
Domain	Pkinase_C	RPS6KA1 RPS6KA2 RPS6KA3	4.92e-04	37	78	3	IPR017892
Domain	Pkinase_C	RPS6KA1 RPS6KA2 RPS6KA3	7.15e-04	42	78	3	PF00433
Domain	Pkinase	RPS6KA1 RPS6KA2 RPS6KA3 TBCK PRKAA1 OXSR1 MAP2K6	1.06e-03	381	78	7	PF00069
Domain	AGC-kinase_C	RPS6KA1 RPS6KA2 RPS6KA3	1.66e-03	56	78	3	IPR000961
Domain	AGC_KINASE_CTER	RPS6KA1 RPS6KA2 RPS6KA3	1.66e-03	56	78	3	PS51285
Domain	S_TK_X	RPS6KA1 RPS6KA2 RPS6KA3	1.66e-03	56	78	3	SM00133
Domain	EFTu-like_2	GUF1 EIF2S3	2.52e-03	18	78	2	IPR004161
Domain	GTP_EFTU_D2	GUF1 EIF2S3	2.52e-03	18	78	2	PF03144
Domain	G_TR_2	GUF1 EIF2S3	2.52e-03	18	78	2	PS51722
Domain	TF_GTP-bd_dom	GUF1 EIF2S3	2.81e-03	19	78	2	IPR000795
Domain	Proteasome	PSMA1 PSMA2	2.81e-03	19	78	2	PF00227
Domain	Proteasome_sua/b	PSMA1 PSMA2	2.81e-03	19	78	2	IPR001353
Domain	Ser/Thr_kinase_AS	RPS6KA1 RPS6KA2 RPS6KA3 PRKAA1 OXSR1 MAP2K6	3.78e-03	357	78	6	IPR008271
Domain	S_TKc	RPS6KA1 RPS6KA2 RPS6KA3 PRKAA1 OXSR1 MAP2K6	3.89e-03	359	78	6	SM00220
Domain	PROTEIN_KINASE_ST	RPS6KA1 RPS6KA2 RPS6KA3 PRKAA1 OXSR1 MAP2K6	4.05e-03	362	78	6	PS00108
Domain	Prot_kinase_dom	RPS6KA1 RPS6KA2 RPS6KA3 TBCK PRKAA1 OXSR1 MAP2K6	4.31e-03	489	78	7	IPR000719
Domain	-	PSMA1 PSMA2	4.48e-03	24	78	2	3.60.20.10
Domain	PROTEIN_KINASE_DOM	RPS6KA1 RPS6KA2 RPS6KA3 TBCK PRKAA1 OXSR1 MAP2K6	4.50e-03	493	78	7	PS50011
Domain	Protein_kinase_ATP_BS	RPS6KA1 RPS6KA2 RPS6KA3 PRKAA1 OXSR1 MAP2K6	5.05e-03	379	78	6	IPR017441
Pathway	REACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING	RPS6KA1 RPS6KA2 RPS6KA3	6.92e-07	5	59	3	MM15108
Pathway	KEGG_MEDICUS_REFERENCE_ERK_RSK_SIGNALING	RPS6KA1 RPS6KA2 RPS6KA3	1.38e-06	6	59	3	M47936
Pathway	REACTOME_RSK_ACTIVATION	RPS6KA1 RPS6KA2 RPS6KA3	2.41e-06	7	59	3	M27369
Pathway	REACTOME_CREB_PHOSPHORYLATION	RPS6KA1 RPS6KA2 RPS6KA3	2.41e-06	7	59	3	M27096
Pathway	REACTOME_CREB_PHOSPHORYLATION	RPS6KA1 RPS6KA2 RPS6KA3	2.41e-06	7	59	3	MM14784
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	RPS6KA1 RPS6KA2 RPS6KA3 PRKAA1 APBA1 NBEA	2.54e-06	94	59	6	M2843
Pathway	REACTOME_CELLULAR_RESPONSES_TO_STIMULI	CRYAB EIF2S3 PSMA1 RPS6KA1 PSMA2 RPS6KA2 RPS6KA3 TLR4 EIF2S3B MAP2K6 KPTN	6.59e-06	505	59	11	MM15548
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING	RPS6KA1 RPS6KA2 RPS6KA3 MAP2K6	1.47e-05	36	59	4	M39908
Pathway	REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS	RPS6KA1 RPS6KA2 RPS6KA3	3.06e-05	15	59	3	MM15103
Pathway	REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK	RPS6KA1 RPS6KA2 RPS6KA3	3.75e-05	16	59	3	MM15477
Pathway	WP_INSULIN_SIGNALING	RPS6KA1 RPS6KA2 RPS6KA3 PRKAA1 PFKM MAP2K6	5.34e-05	160	59	6	MM15956
Pathway	WP_INSULIN_SIGNALING	RPS6KA1 RPS6KA2 RPS6KA3 PRKAA1 PFKM MAP2K6	5.34e-05	160	59	6	M39482
Pathway	REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK	RPS6KA1 RPS6KA2 RPS6KA3	5.43e-05	18	59	3	M657
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE	RPS6KA1 RPS6KA2 RPS6KA3 TLR4 MAP2K6	5.72e-05	99	59	5	MM14660
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	EIF2S3 PSMA1 PSMA2 EIF2S3B ABCC2	5.72e-05	99	59	5	MM14986
Pathway	REACTOME_ERK_MAPK_TARGETS	RPS6KA1 RPS6KA2 RPS6KA3	6.43e-05	19	59	3	MM14780
Pathway	KEGG_MTOR_SIGNALING_PATHWAY	RPS6KA1 RPS6KA2 RPS6KA3 PRKAA1	6.45e-05	52	59	4	M7561
Pathway	REACTOME_MYD88_INDEPENDENT_TLR4_CASCADE	RPS6KA1 RPS6KA2 RPS6KA3 TLR4 MAP2K6	9.05e-05	109	59	5	M29565
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE	RPS6KA1 RPS6KA2 RPS6KA3 TLR4 MAP2K6	9.05e-05	109	59	5	M27012
Pathway	REACTOME_ERK_MAPK_TARGETS	RPS6KA1 RPS6KA2 RPS6KA3	1.01e-04	22	59	3	M13408
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	RPS6KA1 RPS6KA2 RPS6KA3 MAP2K6	1.06e-04	59	59	4	MM15128
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_TLR1_TLR2_CASCADE	RPS6KA1 RPS6KA2 RPS6KA3 TLR4 MAP2K6	1.17e-04	115	59	5	M27013
Pathway	REACTOME_CELL_CYCLE_CHECKPOINTS	KIF18A PHF20 PSMA1 PSMA2 MDC1 CLASP2 HERC2	1.30e-04	271	59	7	MM15388
Pathway	REACTOME_CELLULAR_RESPONSES_TO_STIMULI	CRYAB CDKN2C ATP7A EIF2S3 PSMA1 RPS6KA1 PSMA2 RPS6KA2 RPS6KA3 TLR4 MAP2K6 KPTN	1.35e-04	828	59	12	M27827
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE	RPS6KA1 RPS6KA2 RPS6KA3 TLR4 MAP2K6	1.54e-04	122	59	5	MM14640
Pathway	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	RPS6KA1 RPS6KA2 RPS6KA3 EBP	1.74e-04	67	59	4	M295
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	RPS6KA1 RPS6KA2 RPS6KA3	1.90e-04	27	59	3	MM14779
Pathway	REACTOME_CELL_CYCLE_CHECKPOINTS	KIF18A PHF20 PSMA1 PSMA2 MDC1 CLASP2 HERC2	2.02e-04	291	59	7	M16647
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	RPS6KA1 RPS6KA2 RPS6KA3 PRKAA1 APBA1 NBEA	2.08e-04	205	59	6	M752
Pathway	REACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING	RPS6KA1 RPS6KA2 RPS6KA3	2.12e-04	28	59	3	M837
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	RPS6KA1 RPS6KA2 RPS6KA3	2.12e-04	28	59	3	MM15132
Pathway	REACTOME_INTERLEUKIN_17_SIGNALING	RPS6KA1 RPS6KA2 RPS6KA3 MAP2K6	2.18e-04	71	59	4	M27382
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	RPS6KA1 RPS6KA2 RPS6KA3 PRKAA1 MAP2K6	2.23e-04	132	59	5	M39338
Pathway	BIOCARTA_MAPK_PATHWAY	RPS6KA1 RPS6KA2 RPS6KA3 MAP2K6	2.84e-04	76	59	4	MM1433
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	RPS6KA1 RPS6KA2 RPS6KA3	2.88e-04	31	59	3	M15195
Pathway	BIOCARTA_MAPK_PATHWAY	RPS6KA1 RPS6KA2 RPS6KA3 MAP2K6	3.62e-04	81	59	4	M13863
Pathway	REACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS	RPS6KA1 RPS6KA2 RPS6KA3	4.14e-04	35	59	3	MM15109
Pathway	REACTOME_MYD88_MAL_TIRAP_CASCADE_INITIATED_ON_PLASMA_MEMBRANE	RPS6KA1 RPS6KA2 RPS6KA3 MAP2K6	4.35e-04	85	59	4	MM14645
Pathway	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	RPS6KA1 RPS6KA2 RPS6KA3	4.51e-04	36	59	3	M1315
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_CASCADES	RPS6KA1 RPS6KA2 RPS6KA3 TLR4 MAP2K6	4.67e-04	155	59	5	MM14665
Pathway	REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP	RPS6KA1 RPS6KA2 RPS6KA3	5.72e-04	39	59	3	MM14900
Pathway	REACTOME_RECYCLING_OF_EIF2_GDP	EIF2S3 EIF2S3B	6.08e-04	9	59	2	MM15418
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_CASCADES	RPS6KA1 RPS6KA2 RPS6KA3 TLR4 MAP2K6	7.11e-04	170	59	5	M7494
Pathway	REACTOME_CELLULAR_RESPONSE_TO_MITOCHONDRIAL_STRESS	EIF2S3 EIF2S3B	7.58e-04	10	59	2	MM17234
Pathway	BIOCARTA_EIF_PATHWAY	EIF2S3 EIF2S3B	7.58e-04	10	59	2	MM1394
Pathway	BIOCARTA_EIF2_PATHWAY	EIF2S3 EIF2S3B	7.58e-04	10	59	2	MM1469
Pathway	WP_GLYCOLYSIS_AND_GLUCONEOGENESIS	PKLR PFKM PC	8.72e-04	45	59	3	M39474
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	EIF2S3 PSMA1 PSMA2 ABCC2	8.99e-04	103	59	4	M758
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	RPS6KA1 RPS6KA2 RPS6KA3 PRKAA1 APBA1 NBEA	8.99e-04	270	59	6	M15514
Pathway	WP_TRANSLATION_INHIBITORS_IN_CHRONICALLY_ACTIVATED_PDGFRA_CELLS	RPS6KA1 RPS6KA2 MAP2K6	9.30e-04	46	59	3	M39805
Pathway	WP_THERMOGENESIS	RPS6KA1 RPS6KA2 RPS6KA3 PRKAA1	1.07e-03	108	59	4	M39746
Pathway	REACTOME_SIGNALING_BY_INTERLEUKINS	PSMA1 RPS6KA1 PSMA2 RPS6KA2 RPS6KA3 MAP2K6	1.10e-03	281	59	6	MM15130
Pathway	REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR	EIF2S3 EIF2S3B	1.11e-03	12	59	2	MM14981
Pathway	REACTOME_RECYCLING_PATHWAY_OF_L1	RPS6KA1 RPS6KA2 RPS6KA3	1.12e-03	49	59	3	M891
Pathway	REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP	CDKN2C RPS6KA1 RPS6KA2 RPS6KA3	1.19e-03	111	59	4	M27187
Pathway	WP_SENESCENCEASSOCIATED_SECRETORY_PHENOTYPE_SASP	CDKN2C RPS6KA1 RPS6KA2 RPS6KA3	1.23e-03	112	59	4	M48334
Pathway	WP_GLYCOLYSIS_AND_GLUCONEOGENESIS	PKLR PFKM PC	1.26e-03	51	59	3	MM15928
Pathway	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	RPS6KA1 RPS6KA2 RPS6KA3	1.26e-03	51	59	3	M7955
Pathway	KEGG_MEDICUS_REFERENCE_DOUBLE_STRAND_BREAK_SIGNALING	MDC1 HERC2	1.30e-03	13	59	2	M47832
Pathway	REACTOME_CELLULAR_SENESCENCE	CDKN2C RPS6KA1 RPS6KA2 RPS6KA3 MAP2K6	1.38e-03	197	59	5	M27188
Pathway	REACTOME_STABILIZATION_OF_P53	PHF20 PSMA1 PSMA2	1.48e-03	54	59	3	MM15384
Pathway	REACTOME_CELLULAR_SENESCENCE	RPS6KA1 RPS6KA2 RPS6KA3 MAP2K6	1.54e-03	119	59	4	MM14901
Pathway	REACTOME_STABILIZATION_OF_P53	PHF20 PSMA1 PSMA2	1.74e-03	57	59	3	M27670
Pathway	REACTOME_METABOLISM_OF_POLYAMINES	AZIN2 PSMA1 PSMA2	1.74e-03	57	59	3	MM14955
Pathway	REACTOME_METABOLISM_OF_POLYAMINES	AZIN2 PSMA1 PSMA2	1.92e-03	59	59	3	M747
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	RPS6KA1 RPS6KA2 RPS6KA3	2.11e-03	61	59	3	M152
Pathway	REACTOME_SIGNALING_BY_NTRK1_TRKA	RPS6KA1 RPS6KA2 RPS6KA3	2.31e-03	63	59	3	MM14714
Pathway	REACTOME_G1_S_DNA_DAMAGE_CHECKPOINTS	PHF20 PSMA1 PSMA2	2.42e-03	64	59	3	MM15386
Pathway	BIOCARTA_PROTEASOME_PATHWAY	PSMA1 PSMA2	2.81e-03	19	59	2	M194
Pathway	REACTOME_G1_S_DNA_DAMAGE_CHECKPOINTS	PHF20 PSMA1 PSMA2	2.88e-03	68	59	3	M27672
Pathway	REACTOME_G2_M_CHECKPOINTS	PSMA1 PSMA2 MDC1 HERC2	3.00e-03	143	59	4	MM15383
Pathway	BIOCARTA_IGF1MTOR_PATHWAY	EIF2S3 EIF2S3B	3.12e-03	20	59	2	MM1496
Pathway	KEGG_LONG_TERM_POTENTIATION	RPS6KA1 RPS6KA2 RPS6KA3	3.12e-03	70	59	3	M3115
Pathway	WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS	FAT1 TLR4 MKI67	3.38e-03	72	59	3	M39403
Pathway	REACTOME_SIGNALING_BY_INTERLEUKINS	PSMA1 RPS6KA1 PSMA2 RPS6KA2 RPS6KA3 MAP2K6 F13A1	3.46e-03	473	59	7	M874
Pathway	WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS	FAT1 TLR4 MKI67	3.52e-03	73	59	3	MM15906
Pathway	REACTOME_SIGNALING_BY_NTRKS	RPS6KA1 RPS6KA2 RPS6KA3	3.80e-03	75	59	3	MM14652
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	CDKN2C FANCI RPS6KA1 RPS6KA2 RPS6KA3 PABPC4 PRKAA1 CLASP2 OXSR1 USP9Y ADAM22	6.07e-09	432	82	11	23455922
Pubmed	Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning.	RPS6KA1 RPS6KA2 RPS6KA3	1.26e-08	3	82	3	12393804
Pubmed	The Clinical Implications of RSK1-3 in Human Breast Cancer.	RPS6KA1 RPS6KA2 RPS6KA3	1.26e-08	3	82	3	26977024
Pubmed	Human rsk isoforms: cloning and characterization of tissue-specific expression.	RPS6KA1 RPS6KA2 RPS6KA3	1.26e-08	3	82	3	8141249
Pubmed	Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene.	RPS6KA1 RPS6KA2 RPS6KA3	5.04e-08	4	82	3	9770464
Pubmed	90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.	RPS6KA1 RPS6KA2 RPS6KA3	1.26e-07	5	82	3	10480933
Pubmed	The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.	RPS6KA1 RPS6KA2 RPS6KA3	1.26e-07	5	82	3	37068088
Pubmed	RSK2 is a modulator of craniofacial development.	RPS6KA1 RPS6KA2 RPS6KA3	1.26e-07	5	82	3	24416220
Pubmed	Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission.	RPS6KA1 RPS6KA2 RPS6KA3	1.26e-07	5	82	3	16217014
Pubmed	Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo.	RPS6KA1 RPS6KA2 RPS6KA3	1.26e-07	5	82	3	9915826
Pubmed	The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction.	RPS6KA1 RPS6KA2 RPS6KA3	1.26e-07	5	82	3	15867353
Pubmed	Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation.	RPS6KA1 RPS6KA2 RPS6KA3	1.26e-07	5	82	3	11160957
Pubmed	Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.	RPS6KA1 RPS6KA2 RPS6KA3	2.51e-07	6	82	3	12832467
Pubmed	Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.	RPS6KA1 RPS6KA2 RPS6KA3	2.51e-07	6	82	3	8688081
Pubmed	NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation.	RPS6KA1 RPS6KA2 RPS6KA3	2.51e-07	6	82	3	11175347
Pubmed	The MAP kinase ERK5 binds to and phosphorylates p90 RSK.	RPS6KA1 RPS6KA2 RPS6KA3	2.51e-07	6	82	3	16626623
Pubmed	Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases.	RPS6KA1 RPS6KA2 RPS6KA3	2.51e-07	6	82	3	8939914
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	FAT1 ATP7A TTC28 EIF2S3 PABPC4 MKI67 PKLR ZFHX3 NBEA CLASP2 ANKRD50 PC	2.82e-07	777	82	12	35844135
Pubmed	CREB is a regulatory target for the protein kinase Akt/PKB.	RPS6KA1 RPS6KA2 RPS6KA3	7.01e-07	8	82	3	9829964
Pubmed	Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases.	RPS6KA1 RPS6KA3 TLR4	1.50e-06	10	82	3	29229781
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	PHF20 EIF2S3 RPS6KA1 RPS6KA2 PKLR PYGL EIF2S3B PFKM PC ADAM22	2.07e-06	621	82	10	22794259
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	CDKN2C FANCI PSMA1 RPS6KA1 PSMA2 RPS6KA3 PRKAA1 PYGL EIF2S3B OXSR1 PFKM ANKRD50	2.98e-06	974	82	12	28675297
Pubmed	Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos.	RPS6KA1 RPS6KA2 RPS6KA3	4.51e-06	14	82	3	15305288
Pubmed	Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.	RPS6KA1 RPS6KA2 RPS6KA3	4.51e-06	14	82	3	9687510
Pubmed	RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.	RPS6KA1 RPS6KA3	5.49e-06	2	82	2	19716794
Pubmed	The RSK family of kinases: emerging roles in cellular signalling.	RPS6KA1 RPS6KA3	5.49e-06	2	82	2	18813292
Pubmed	Peritoneal and hematogenous metastases of ovarian cancer cells are both controlled by the p90RSK through a self-reinforcing cell autonomous mechanism.	RPS6KA1 RPS6KA3	5.49e-06	2	82	2	26625210
Pubmed	S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover.	RPS6KA1 RPS6KA3	5.49e-06	2	82	2	17494629
Pubmed	ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.	ARG2 PRKAA1	5.49e-06	2	82	2	25484082
Pubmed	Immunohistochemical analysis of S6K1 and S6K2 expression in human breast tumors.	RPS6KA1 RPS6KA2	5.49e-06	2	82	2	15112576
Pubmed	Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner.	RPS6KA1 RPS6KA3	5.49e-06	2	82	2	25889895
Pubmed	MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit.	RPS6KA2 RPS6KA3	5.49e-06	2	82	2	11495723
Pubmed	A novel αB-crystallin R123W variant drives hypertrophic cardiomyopathy by promoting maladaptive calcium-dependent signal transduction.	CRYAB MYBPC3	5.49e-06	2	82	2	37435054
Pubmed	Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.	RPS6KA1 RPS6KA3	5.49e-06	2	82	2	2779569
Pubmed	Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain.	EIF2S3 EIF2S3B	5.49e-06	2	82	2	16325480
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	EIF2S3 EIF2S3B USP9Y	5.63e-06	15	82	3	14762062
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	EIF2S3 EIF2S3B USP9Y	1.00e-05	18	82	3	12023983
Pubmed	Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules.	RPS6KA1 RPS6KA2 RPS6KA3	1.40e-05	20	82	3	21421818
Pubmed	SH3P2 is a negative regulator of cell motility whose function is inhibited by ribosomal S6 kinase-mediated phosphorylation.	RPS6KA1 RPS6KA3	1.64e-05	3	82	2	21501342
Pubmed	p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling.	RPS6KA1 RPS6KA3	1.64e-05	3	82	2	19332537
Pubmed	p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors.	RPS6KA1 RPS6KA3	1.64e-05	3	82	2	36612117
Pubmed	Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells.	RPS6KA1 RPS6KA3	1.64e-05	3	82	2	19036157
Pubmed	Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy.	RPS6KA1 RPS6KA3	1.64e-05	3	82	2	15226426
Pubmed	Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase.	RPS6KA2 RPS6KA3	1.64e-05	3	82	2	12016217
Pubmed	Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.	RPS6KA1 RPS6KA3	1.64e-05	3	82	2	26158630
Pubmed	Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1.	RPS6KA1 RPS6KA2	1.64e-05	3	82	2	8663493
Pubmed	The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition.	NFIL3 ABCC2	1.64e-05	3	82	2	31244920
Pubmed	Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease.	RPS6KA1 RPS6KA3	1.64e-05	3	82	2	27063456
Pubmed	Deficiency in the anti-aging gene Klotho promotes aortic valve fibrosis through AMPKα-mediated activation of RUNX2.	KL PRKAA1	1.64e-05	3	82	2	27242197
Pubmed	The signal-dependent coactivator CBP is a nuclear target for pp90RSK.	RPS6KA1 RPS6KA2	1.64e-05	3	82	2	8756728
Pubmed	Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells.	RPS6KA1 RPS6KA3	1.64e-05	3	82	2	22031759
Pubmed	Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.	RPS6KA1 RPS6KA3	1.64e-05	3	82	2	22041125
Pubmed	Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase.	CRYAB PRKAA1 C19orf47	2.47e-05	24	82	3	19616115
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	TCP11L2 TTC28 EIF2S3 PSMA1 PSMA2 MDC1 PABPC4 HERC2	2.91e-05	513	82	8	25798074
Pubmed	MD-2: the Toll 'gatekeeper' in endotoxin signalling.	RPS6KA1 RPS6KA3 TLR4 MAP2K6	2.91e-05	74	82	4	15276183
Pubmed	RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.	RPS6KA2 RPS6KA3	3.28e-05	4	82	2	7623830
Pubmed	Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.	RPS6KA1 RPS6KA3	3.28e-05	4	82	2	11507039
Pubmed	p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.	RPS6KA2 RPS6KA3	3.28e-05	4	82	2	21527514
Pubmed	Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.	EIF2S3 EIF2S3B	3.28e-05	4	82	2	31836389
Pubmed	Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase.	RPS6KA1 RPS6KA2	3.28e-05	4	82	2	10521512
Pubmed	Rsk2 allosterically activates estrogen receptor alpha by docking to the hormone-binding domain.	RPS6KA1 RPS6KA3	3.28e-05	4	82	2	11432835
Pubmed	14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.	RPS6KA1 RPS6KA2	3.28e-05	4	82	2	10949026
Pubmed	Coffin-Lowry syndrome: a role for RSK2 in mammalian neurogenesis.	RPS6KA3 MKI67	3.28e-05	4	82	2	20832397
Pubmed	Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2.	RPS6KA1 RPS6KA3	3.28e-05	4	82	2	25513777
Pubmed	Complete dependence on IRAK4 kinase activity in TLR2, but not TLR4, signaling pathways underlies decreased cytokine production and increased susceptibility to Streptococcus pneumoniae infection in IRAK4 kinase-inactive mice.	RPS6KA1 TLR4	3.28e-05	4	82	2	23209321
Pubmed	Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.	CRYAB ATP7A EIF2S3 EIF2S3B	4.58e-05	83	82	4	19799774
Pubmed	Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity.	RPS6KA1 PRKAA1	5.47e-05	5	82	2	11171059
Pubmed	The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous.	PSMA1 PSMA2	5.47e-05	5	82	2	1888762
Pubmed	Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes.	RPS6KA2 RPS6KA3	5.47e-05	5	82	2	15526037
Pubmed	BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival.	RPS6KA1 RPS6KA2	5.47e-05	5	82	2	10837486
Pubmed	Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes.	PRKAA1 TLR4	5.47e-05	5	82	2	26232429
Pubmed	The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.	RPS6KA1 RPS6KA3	5.47e-05	5	82	2	15861136
Pubmed	Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells.	CRYAB MKI67	5.47e-05	5	82	2	21600198
Pubmed	Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes).	PSMA1 PSMA2	5.47e-05	5	82	2	2025653
Pubmed	Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.	RPS6KA1 RPS6KA3	5.47e-05	5	82	2	11139588
Pubmed	The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning.	RPS6KA1 RPS6KA3	5.47e-05	5	82	2	26401001
Pubmed	Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.	RPS6KA1 RPS6KA3	5.47e-05	5	82	2	18722121
Pubmed	pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167.	RPS6KA1 RPS6KA3	5.47e-05	5	82	2	9528769
Pubmed	Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation.	RPS6KA1 RPS6KA3	5.47e-05	5	82	2	18402937
Pubmed	C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.	RPS6KA1 RPS6KA2	5.47e-05	5	82	2	11684016
Pubmed	Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha.	RPS6KA1 RPS6KA2	5.47e-05	5	82	2	10635333
Pubmed	Critical role for Rsk2 in T-lymphocyte activation.	RPS6KA1 RPS6KA3	5.47e-05	5	82	2	17938253
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	NACC1 NFIL3 FANCI EIF2S3 ARID2 PSMA1 PSMA2 PABPC4 MKI67 PYGL PFKM	5.55e-05	1103	82	11	34189442
Pubmed	Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.	PRKAA1 PKLR PYGL PC	7.14e-05	93	82	4	27215380
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	RPS6KA1 RPS6KA3 PABPC4 PRKAA1 MKI67 AHNAK2	7.63e-05	298	82	6	30737378
Pubmed	Angelman syndrome-associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome.	PSMA1 PSMA2 HERC2	7.83e-05	35	82	3	30257870
Pubmed	Late embryonic and postnatal development of interstitial cells of cajal in mouse esophagus: distribution, proliferation and kit dependence.	MKI67 ANO1	8.19e-05	6	82	2	22269660
Pubmed	Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.	RPS6KA1 RPS6KA2	8.19e-05	6	82	2	9381178
Pubmed	Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.	RPS6KA1 RPS6KA3	8.19e-05	6	82	2	11297520
Pubmed	HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.	MDC1 HERC2	8.19e-05	6	82	2	20023648
Pubmed	Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.	RPS6KA1 PRKAA1	8.19e-05	6	82	2	14709557
Pubmed	A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin.	RPS6KA1 PRKAA1	8.19e-05	6	82	2	15024086
Pubmed	MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo.	TLR4 MKI67	8.19e-05	6	82	2	35043940
Pubmed	An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes.	STEAP4 F13A1	8.19e-05	6	82	2	26018251
Pubmed	A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.	CYP17A1 EBP MKI67	9.26e-05	37	82	3	26108225
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	PSMA1 PSMA2 PABPC4 MKI67 PYGL USP4	9.99e-05	313	82	6	16196087
Pubmed	The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.	PSMA1 PSMA2	1.14e-04	7	82	2	10983987
Pubmed	The alpha4 and alpha7 subunits and assembly of the 20S proteasome.	PSMA1 PSMA2	1.14e-04	7	82	2	15225636
Pubmed	Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development.	EIF2S3 EIF2S3B	1.14e-04	7	82	2	15669143
Pubmed	Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3.	RPS6KA1 RPS6KA3	1.14e-04	7	82	2	12562765
Interaction	IGLL1 interactions	FAM25G FAT1 FAM25A FAM25C	1.17e-07	12	81	4	int:IGLL1
Interaction	COX16 interactions	FAM25G FAM25A FAM25C KPTN	7.02e-06	31	81	4	int:COX16
Interaction	TOMM20L interactions	FAM25G FAM25A FAM25C	7.36e-06	10	81	3	int:TOMM20L
Interaction	ARMC10 interactions	FAM25G FAM25A FAM25C AHNAK2	1.45e-05	37	81	4	int:ARMC10
Interaction	KLHL35 interactions	FAM25G FAM25A FAM25C	2.75e-05	15	81	3	int:KLHL35
Interaction	ZFAND3 interactions	FAM25G FAM25A FAM25C	4.08e-05	17	81	3	int:ZFAND3
Interaction	FRK interactions	RPS6KA1 TBCK MKI67 OXSR1	4.85e-05	50	81	4	int:FRK
Interaction	STK11 interactions	ARG2 CDKN2C CYP17A1 ARID2 RPS6KA3 PRKAA1 HERC2 MAP2K6	4.96e-05	326	81	8	int:STK11
Interaction	MIEF1 interactions	FAM25G PSMA1 FAM25A FAM25C	5.24e-05	51	81	4	int:MIEF1
Interaction	IRGC interactions	RPS6KA1 RPS6KA2 RPS6KA3	6.79e-05	20	81	3	int:IRGC
Interaction	GPD1 interactions	FAM25G FAM25A FAM25C	1.05e-04	23	81	3	int:GPD1
Interaction	AGPAT1 interactions	CRYAB RPS6KA1 RPS6KA2 RPS6KA3 STEAP4 OXSR1 AHNAK2	1.05e-04	269	81	7	int:AGPAT1
Cytoband	Xp22.2-p22.1	EIF2S3 RPS6KA3	3.14e-05	5	82	2	Xp22.2-p22.1
GeneFamily	Mitogen-activated protein kinase-activated protein kinases	RPS6KA1 RPS6KA2 RPS6KA3	3.64e-06	11	52	3	1156
Coexpression	FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN	CRYAB GATD3 GJB1 FAT1 KL CYP17A1 RPS6KA3 CLASP2 ABCC2 PC	8.83e-06	553	82	10	M1475
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDKN2C APBA1 DNAH2 MKI67 PHYHD1 F13A1	5.55e-07	162	82	6	ec29c6f1c31e41ddcb041a49c593910edaf0532c
ToppCell	facs-Lung-EPCAM-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF18A GUF1 MDC1 TBCK EML6 FAM131A	5.96e-07	164	82	6	1d0d88132baaa3154c3e6e4ef0aff795afab08a2
ToppCell	facs-Lung-EPCAM-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF18A GUF1 MDC1 TBCK EML6 FAM131A	5.96e-07	164	82	6	bd2e10b015d5e6a338675500ec5d81dc39583b3e
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CRYAB FAT1 RPS6KA2 ANO1 ZFHX3 ANKRD50	1.89e-06	200	82	6	b5b5a32925f225610fe25a021a742d6397162863
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FAT1 RPS6KA2 ANO1 ZFHX3 NBEA ANKRD50	1.89e-06	200	82	6	d2fcd3bd7c3223875f027eeb48ff621192a5f242
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FAT1 RPS6KA2 APBA1 ANO1 ZFHX3 ANKRD50	1.89e-06	200	82	6	786f1ae53e60b5ffbf4bfd393d10b802478148b3
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYAB GJB1 EML6 SEC11C F13A1	4.59e-06	132	82	5	3661665ed5b257f51530122cb9a9c849b5baa1fb
ToppCell	facs-BAT-Fat-3m-Myeloid-myeloid_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARG2 NFIL3 RNF149 PYGL F13A1	1.36e-05	165	82	5	bfe330751d34813af7540765b490406078c40da7
ToppCell	facs-BAT-Fat-3m-Myeloid\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARG2 NFIL3 RNF149 PYGL F13A1	1.36e-05	165	82	5	8bdeacbb47948fabae2575689f811a9fad47f779
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJB1 PKLR PYGL ABCC2 PC	1.48e-05	168	82	5	b98af4043dfa5dfa4413e482879fad88de484675
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJB1 PKLR PYGL ABCC2 PC	1.48e-05	168	82	5	073b53d4cee6bc8c5c6fce51cf6cd9c316478f69
ToppCell	droplet-Liver-HEPATOCYTES\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJB1 PKLR PYGL ABCC2 PC	1.52e-05	169	82	5	f195467438c589f87224bde7da720dea072d110c
ToppCell	droplet-Liver-HEPATOCYTES-1m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJB1 PKLR PYGL ABCC2 PC	1.52e-05	169	82	5	7785cab967a33560830c394c918d6ce625103858
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PABPC4 PKLR PYGL ABCC2 PC	1.80e-05	175	82	5	5c38d4b6c03473d841e6203a7efaa6dcb2d59386
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF18A APBA1 MKI67 SEC11C F13A1	1.85e-05	176	82	5	90f8bb11f339f67f08692a0c33dd420f5cda2861
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FAT1 RPS6KA2 APBA1 ANO1 ZFHX3	2.29e-05	184	82	5	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FAT1 RPS6KA2 APBA1 ANO1 ZFHX3	2.29e-05	184	82	5	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	RA-14._Fibroblast_III\|RA / Chamber and Cluster_Paper	FAT1 PHF20 NFIL3 APBA1 STEAP4	2.60e-05	189	82	5	46e9a58aacd79db5a02898a8c7244e1884adcfd1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRYAB FAT1 TTC28 PKHD1 PTH2R	2.60e-05	189	82	5	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CRYAB FAT1 ANO1 ZFHX3 ADAM22	2.60e-05	189	82	5	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CRYAB FAT1 ANO1 ZFHX3 ADAM22	2.74e-05	191	82	5	08042952431ca1a6fd7dfc13f36eb28643979598
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYAB GJB1 PKHD1 ANO1 PHYHD1	2.81e-05	192	82	5	f3133bbbf938a39062a9b1d1181003bb48174695
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	TCP11L2 TTC28 ARID2 RPS6KA3 TBCK	2.81e-05	192	82	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CRYAB FAT1 ANO1 ZFHX3 ADAM22	2.81e-05	192	82	5	992d08092edbc68c47b945deb8708379738c239a
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	TCP11L2 TTC28 ARID2 RPS6KA3 TBCK	2.88e-05	193	82	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	COVID_vent-Myeloid-Monocytic-Neutrophil\|COVID_vent / Disease condition, Lineage, Cell class and subclass	NFIL3 TLR4 RNF149 STEAP4 PYGL	2.95e-05	194	82	5	eb23b171e429165dd26a64377eae7fa2ce25f547
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_3\|COVID-19_Mild / Disease condition and Cell class	NFIL3 TLR4 PYGL PCNX1 F13A1	3.10e-05	196	82	5	f245e929a286cb097130572e1027b4f01be8b04d
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT1 MKI67 ANO1 FAM25A AHNAK2	3.18e-05	197	82	5	fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell	severe-Lymphocytic-CD4_T_cells_2\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NFIL3 TLR4 RNF149 STEAP4 PYGL	3.18e-05	197	82	5	3b71e523d8a68f131def17233385df371db70db5
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT1 MKI67 ANO1 FAM25A AHNAK2	3.18e-05	197	82	5	61c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT1 MKI67 ANO1 FAM25A AHNAK2	3.18e-05	197	82	5	dcabea5c50c133c9a4e294e447462d0393174ea7
ToppCell	severe-Others-Megakaryocytes\|Others / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	TLR4 RNF149 STEAP4 PYGL F13A1	3.18e-05	197	82	5	fc0864e2de2d9f99084586b467551b6da535d933
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT1 MKI67 ANO1 FAM25A AHNAK2	3.25e-05	198	82	5	e06d41a7254a09e037ec404be2d8c352d5cbd7f4
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TLR4 RNF149 STEAP4 PYGL F13A1	3.25e-05	198	82	5	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	COVID-19_Mild-Classical_Monocyte\|COVID-19_Mild / Disease condition and Cell class	NFIL3 TLR4 STEAP4 PYGL F13A1	3.25e-05	198	82	5	30ada3de865b6fb2b14196a1cbfd4740c6a57ce3
ToppCell	LPS_IL1RA-Hematopoietic_Myeloid\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ARG2 TLR4 STEAP4 PYGL F13A1	3.33e-05	199	82	5	0e696f13c9bd135fbb31368d6dca29897d6a1a25
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CRYAB FAT1 ANO1 ZFHX3 ADAM22	3.41e-05	200	82	5	f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FAT1 RPS6KA2 ANO1 ZFHX3 ANKRD50	3.41e-05	200	82	5	4e1e19214aeebbdca004de7faaf4cc9d18498591
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_only / Treatment groups by lineage, cell group, cell type	FAT1 RPS6KA2 ANO1 ZFHX3 NBEA	3.41e-05	200	82	5	69edc375d85689300d1dbc1217fedc40063ecdcb
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Intermediate\|3m / Sample Type, Dataset, Time_group, and Cell type.	ARG2 CRYAB TTC28 SEC11C PFKM	3.41e-05	200	82	5	cbd0b9188a94778ffa539912aeb2a4378f0ab88f
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_B3-5\|TCGA-Thymus / Sample_Type by Project: Shred V9	FAM25G PSMA2 SERPINA7 AHNAK2	7.17e-05	120	82	4	9d4e630e1d3b9adf94a1884071bfe46edaa3f0c1
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MKI67 PYGL ABCC2 F13A1	1.53e-04	146	82	4	45d7cb73776e60d22f335a651845e21e16948fcc
ToppCell	368C-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MKI67 PLD6 MAP2K6 F13A1	1.70e-04	150	82	4	c3ad5fa41eb636a5d691c0268c0f1c32cd0de658
ToppCell	368C-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	MKI67 PLD6 MAP2K6 F13A1	1.70e-04	150	82	4	78b8029e71d26f336a46274c8afef3435bf536b9
ToppCell	facs-Lung-Endomucin-3m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFIL3 RNF149 PYGL F13A1	1.78e-04	152	82	4	962f5bf632da79bd933193d3edd7d89941a85831
ToppCell	facs-Trachea-24m-Hematologic-myeloid-granulocyte-granulocyte_l8\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARG2 RNF149 PYGL USP9Y	1.83e-04	153	82	4	338684d420b01e32918fa19048ccdda234942ce1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CRYAB EML6 PKHD1 PTH2R	1.83e-04	153	82	4	d6526d17826470534b766df144c74e73eb83fdad
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF320 ZNF813 SEC11C PLD6	1.92e-04	155	82	4	51f6447945389649d99dcf7603b396195c631ead
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic-Mast_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF320 ZNF813 SEC11C PLD6	1.92e-04	155	82	4	23dc71cab28094ca0ac4d2baf4e24871ed107781
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GJB1 NACC1 STEAP4 MYBPC3	1.92e-04	155	82	4	62b59cb32b12bd55b19e98786a866d788fc9e4bf
ToppCell	facs-Lung-Endomucin_-18m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARG2 RNF149 PYGL F13A1	2.02e-04	157	82	4	2b60de520edf167f5ca790b478557a778435b3d9
ToppCell	Goblet\|World / Class top	CRYAB GJB1 SEC11C FAM25C	2.02e-04	157	82	4	b352aa37d662629db6a9c6def9ee6d7c49a9071c
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFIL3 C19orf47 PYGL F13A1	2.07e-04	158	82	4	ad1040bce6ad655c2502d9abb02507ecff177f83
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFIL3 C19orf47 PYGL F13A1	2.07e-04	158	82	4	ac7aef01eda1dca80d6c5b508649fcad55803a67
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-3\|TCGA-Skin / Sample_Type by Project: Shred V9	ATP7A TTC28 PLD6 CLASP2	2.12e-04	159	82	4	fb222c42f66901852b01cec073ec0732245ee973
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKLR PYGL ABCC2 PC	2.17e-04	160	82	4	c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-stromal_related\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARG2 ANO1 ZFHX3 PFKM	2.22e-04	161	82	4	8aaca49b53a551395f4025ac4e535c7b0ce41a49
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARG2 ANO1 ZFHX3 PFKM	2.22e-04	161	82	4	deb10628d258fb813c293f81fb71be8e383dc82a
ToppCell	droplet-Limb_Muscle-nan-18m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARG2 C19orf47 RNF149 F13A1	2.39e-04	164	82	4	8d089844896e84935eab705ebe54f125c4b6d9ca
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_2\|390C / Donor, Lineage, Cell class and subclass (all cells)	FANCI APBA1 MKI67 F13A1	2.39e-04	164	82	4	ad508f53009efdd1dae7abcdb5431387f3f7e7b2
ToppCell	droplet-Limb_Muscle-nan-18m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARG2 C19orf47 RNF149 F13A1	2.39e-04	164	82	4	17fb1421476ba44999b1165f2576514f74c1f882
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Plasma_cells-IgM_plasma_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF320 TTC28 EML6 SEC11C	2.44e-04	165	82	4	6e8370b8e747d8ef44a2413a993291a3cd83a77c
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJB1 PKLR PYGL PC	2.44e-04	165	82	4	d449a568664a81d9b5538e8f409301448a32ac37
ToppCell	facs-Lung-nan-3m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFIL3 RNF149 PYGL F13A1	2.44e-04	165	82	4	720649f330382ea2a68c64a5344160a048afb8f1
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	FANCI APBA1 MKI67 ADAM22	2.44e-04	165	82	4	a5c3af634d2698f9a01cf074791756b7669f9fff
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFIL3 RNF149 PYGL F13A1	2.50e-04	166	82	4	82fa07632f7e586698fbf37381715b40f9f6ae3a
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TLR4 MKI67 PKHD1 F13A1	2.50e-04	166	82	4	bb8135119dc37fdbba476599a56d368f422688dc
ToppCell	facs-Lung-EPCAM-18m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFIL3 RNF149 PYGL F13A1	2.50e-04	166	82	4	bf6c35c3e67ef4ca98a38926c6f7923ecca0508a
ToppCell	facs-Lung-EPCAM-18m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFIL3 RNF149 PYGL F13A1	2.50e-04	166	82	4	433128b7d964b32faa0bf437a02facc819ab1405
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFIL3 RNF149 PYGL F13A1	2.50e-04	166	82	4	0d03926452414f232c77fd15d5f48d148f9fca3b
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CDKN2C KIF18A FANCI MKI67	2.56e-04	167	82	4	9280558baddea51aae47f3383d895a9b0c6749a4
ToppCell	droplet-Limb_Muscle-nan-18m-Myeloid-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARG2 C19orf47 RNF149 F13A1	2.56e-04	167	82	4	7f9eedf68a800159c5642e04dd9569ae58109bd5
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAT1 FANCI MAP2K6 MYBPC3	2.56e-04	167	82	4	91b14df450bfb6a2b406c88f8c75cd51eeb9e82b
ToppCell	droplet-Lung-nan-18m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARG2 NFIL3 RNF149 PYGL	2.61e-04	168	82	4	da1eee804456d910c17f145a5ce79c74a808a2c2
ToppCell	droplet-Lung-18m-Hematologic-myeloid-neutrophil\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARG2 RNF149 STEAP4 PYGL	2.61e-04	168	82	4	937332580a522826b820e0b09080013f19f58479
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDKN2C KIF18A MKI67 SEC11C	2.61e-04	168	82	4	52fd65024af8683db11d931f7563cbe8eb815d1c
ToppCell	droplet-Lung-18m-Hematologic-myeloid-neutrophil-neutrophil\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARG2 RNF149 STEAP4 PYGL	2.61e-04	168	82	4	b0376e3687fa85f091654196403eecedc219d0cd
ToppCell	facs-Lung-18m-Hematologic-myeloid-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NFIL3 RNF149 PYGL F13A1	2.61e-04	168	82	4	0ffad93ba2fb5d4cfda2c13011059555475dcfc8
ToppCell	facs-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NFIL3 RNF149 PYGL F13A1	2.61e-04	168	82	4	ab1fb9b2cc7c5853b7fbd373e1784a9a31f96d38
ToppCell	facs-Lung-nan-3m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFIL3 RNF149 PYGL F13A1	2.67e-04	169	82	4	05b138511039f1255a5f647040b1b9bdf222bd52
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CDKN2C KIF18A FANCI MKI67	2.67e-04	169	82	4	e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell	facs-Lung-nan-3m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFIL3 RNF149 PYGL F13A1	2.67e-04	169	82	4	bf0a97f53d6e3f9ffeaeae0402b010c49a6cccb7
ToppCell	facs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NFIL3 RNF149 PYGL F13A1	2.67e-04	169	82	4	907e4c7d0df6dd46664d69834251aebca8e1dd1e
ToppCell	droplet-Spleen-SPLEEN-1m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF149 PKLR PYGL F13A1	2.74e-04	170	82	4	7cb7ad9ab064b6ea452545d145e5b1d4090cd4c1
ToppCell	facs-Marrow-T-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP7A APBA1 USP9Y F13A1	2.74e-04	170	82	4	a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCell	droplet-Spleen-SPLEEN-1m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF149 PKLR PYGL F13A1	2.74e-04	170	82	4	db7cee7e518debb2cbe9eeae05d47e14b69cb8e3
ToppCell	facs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP7A APBA1 USP9Y F13A1	2.74e-04	170	82	4	ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APBA1 FAM131A ANKRD50 F13A1	2.80e-04	171	82	4	d1e87478d8c0329e662849823f5c7604f20e1b1a
ToppCell	droplet-Lung-18m-Hematologic-myeloid\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NFIL3 RNF149 PYGL F13A1	2.80e-04	171	82	4	33869b9fab2c94cb33f1cc659073fcf2bb30c22d
ToppCell	droplet-Lung-21m-Hematologic-myeloid\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NFIL3 RNF149 PYGL F13A1	2.80e-04	171	82	4	22ad6de44e1d3f72a3d78d46fd26a5743a4f84a5
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	KIF18A FANCI MKI67 PKLR	2.86e-04	172	82	4	8d20eda599abf1e9e3e3b90f314acddee6a465a4
ToppCell	facs-BAT-Fat-18m-Myeloid-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFIL3 C19orf47 RNF149 F13A1	2.86e-04	172	82	4	36fe66a8c0aecee7a19269be23210c0ed7abb155
ToppCell	facs-BAT-Fat-3m-Myeloid-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFIL3 C19orf47 RNF149 F13A1	2.86e-04	172	82	4	5f18c3f8eb8b7928901eede44c9b84b3c5efa1a9
ToppCell	facs-Lung-24m-Hematologic-myeloid-classical_monocyte\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NFIL3 RNF149 PYGL F13A1	2.86e-04	172	82	4	f557ec1b4d08b42559da02dd1f2387283c6380a2
ToppCell	367C-Lymphocytic-ILC-ILC-2\|367C / Donor, Lineage, Cell class and subclass (all cells)	CDKN2C PHF20 PRKAA1 MKI67	2.92e-04	173	82	4	0451450605521fecb27a958628870d268adfb023
ToppCell	LV-11._Adipocyte\|LV / Chamber and Cluster_Paper	PYGL PPIP5K1 PC MAP2K6	2.92e-04	173	82	4	c2d3fcb3de71015d03d14c63450853d2b03ffa71
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-plasmablast-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	FANCI EML6 MKI67 SEC11C	3.05e-04	175	82	4	89bf89466191da14896ed8928027f5b911436c22
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FANCI RPS6KA2 EBP MKI67	3.05e-04	175	82	4	86dfce849b2ec023a72f7e887fa681b117155e51
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CRYAB FAT1 PLD6 PTH2R	3.12e-04	176	82	4	33323c97afe509147956b8df9f92ca6b0537e604
ToppCell	PND07-Immune\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRLF3 SEC11C PYGL F13A1	3.12e-04	176	82	4	2f87f49b64c6f89823d540172a8e923ebaa6d6cd
Drug	Hesperetin [520-33-2]; Up 200; 13.2uM; MCF7; HT_HG-U133A	TTC28 CYP17A1 ANO1 PCNX1 ADAM22 AHNAK2 KPTN	6.49e-06	199	80	7	1531_UP
Drug	BI D1870	RPS6KA1 RPS6KA2 RPS6KA3	6.75e-06	11	80	3	ctd:C516541
Drug	pentabromodiphenyl ether	ARG2 CRYAB KLHL28 NFIL3 EIF2S3 CYP17A1 PSMA1 RPS6KA2 STEAP4 PLD6 ABCC2 MAP2K6 ADAM22 F13A1 SERPINA7 AHNAK2	7.01e-06	1266	80	16	ctd:C086401
Drug	Glucose	ARG2 CDKN2C EIF2S3 ARID2 PSMA1 RPS6KA1 PRKAA1 TLR4 MKI67 PKLR SEC11C PYGL PCNX1 NBEA CLASP2 ABCC2 PC	7.06e-06	1420	80	17	ctd:D005947
Drug	phenylurethane	PKLR PYGL PFKM	8.98e-06	12	80	3	CID000007591
Drug	pyrazole	CRYAB CYP17A1 PSMA1 PSMA2 PYGL PC SERPINA7	1.01e-05	213	80	7	ctd:C031280
Drug	Cymal-6	FAT1 RPS6KA1 RPS6KA2	1.16e-05	13	80	3	CID000447688
Drug	Ovta	RPS6KA1 RPS6KA2 RPS6KA3	1.48e-05	14	80	3	CID003081047
Drug	AD 288	RPS6KA1 RPS6KA2 RPS6KA3	1.48e-05	14	80	3	CID000073553
Drug	R165481	RPS6KA1 RPS6KA2 RPS6KA3	2.26e-05	16	80	3	CID005459348
Drug	allulose 6-phosphate	CRYAB PKLR PKHD1 PYGL PFKM PC	2.30e-05	162	80	6	CID000000603
Drug	alloxan	PSMA2 PKLR PYGL PFKM PC	3.46e-05	105	80	5	CID000005781
Drug	Dimethylnitrosamine	CRYAB FAT1 CYP17A1 PSMA1 RPS6KA1 PSMA2 EBP TLR4 MKI67 PKLR PC SERPINA7	4.69e-05	865	80	12	ctd:D004128
Drug	H-89, Dihydrochloride; Up 200; 0.5uM; MCF7; HT_HG-U133A	TTC28 RPS6KA1 RPS6KA2 PCNX1 CLASP2 ADAM22	6.31e-05	194	80	6	6878_UP
Drug	fluoropyruvate	PKLR PFKM PC	7.03e-05	23	80	3	CID000067946
Drug	N,N'-bis(3-aminopropyl)cadaverine	ARG2 AZIN2	7.28e-05	4	80	2	CID003080781
Drug	AC1Q6RZ4	CRYAB PKLR PYGL PFKM PC	7.37e-05	123	80	5	CID000000719
Drug	Carbenoxolone disodium salt [7421-40-1]; Up 200; 6.6uM; MCF7; HT_HG-U133A	APBA1 ANO1 USP9Y F13A1 PTH2R MYBPC3	7.46e-05	200	80	6	4173_UP
Disease	Coffin-Lowry syndrome (implicated_via_orthology)	RPS6KA1 RPS6KA2 RPS6KA3	7.96e-08	4	81	3	DOID:3783 (implicated_via_orthology)
Disease	Liver carcinoma	CDKN2C KIF18A GJB1 FANCI CYP17A1 ARID2 RPS6KA3 TLR4 MKI67 PYGL	1.30e-06	507	81	10	C2239176
Disease	MEHMO syndrome (implicated_via_orthology)	EIF2S3 EIF2S3B	7.44e-06	2	81	2	DOID:0060801 (implicated_via_orthology)
Disease	Liver Cirrhosis, Experimental	CRYAB FAT1 CYP17A1 TLR4 MKI67 PKLR STEAP4 NBEA ABCC2 PC SERPINA7	8.61e-06	774	81	11	C0023893
Disease	glucose metabolism disease (implicated_via_orthology)	EIF2S3 TLR4 EIF2S3B	6.21e-05	28	81	3	DOID:4194 (implicated_via_orthology)
Disease	hypopituitarism (implicated_via_orthology)	EIF2S3 EIF2S3B	1.11e-04	6	81	2	DOID:9406 (implicated_via_orthology)
Disease	leukodystrophy (implicated_via_orthology)	EIF2S3 EIF2S3B	2.65e-04	9	81	2	DOID:10579 (implicated_via_orthology)
Disease	pancreatic hormone measurement	FAM25G FAM25C	3.30e-04	10	81	2	EFO_0020621
Disease	Seizures	ATP7A TBCK NBEA ABCC2 KPTN	3.41e-04	218	81	5	C0036572
Disease	Tinnitus	APBA1 PKHD1 ANO1 ISG20L2	4.60e-04	130	81	4	HP_0000360
Disease	pulmonary emphysema (implicated_via_orthology)	KL TLR4	5.69e-04	13	81	2	DOID:9675 (implicated_via_orthology)
Disease	breast cancer (is_implicated_in)	CYP17A1 PRKAA1 TLR4 MKI67	7.88e-04	150	81	4	DOID:1612 (is_implicated_in)
Disease	Colonic Neoplasms	CRYAB ATP7A MKI67 MAP2K6	8.28e-04	152	81	4	C0009375
Disease	Hypogonadism	EIF2S3 CYP17A1	8.71e-04	16	81	2	C0020619
Disease	Malignant tumor of colon	CRYAB ATP7A MKI67 MAP2K6	9.78e-04	159	81	4	C0007102
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	DNAH2 ZFHX3	1.37e-03	20	81	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	bilirubin measurement	NFIL3 PABPC4 PKLR ISG20L2 ABCC2 ANKRD50	1.38e-03	442	81	6	EFO_0004570
Disease	disease of metabolism (implicated_via_orthology)	PKLR PFKM	1.51e-03	21	81	2	DOID:0014667 (implicated_via_orthology)
Disease	Prostatic Neoplasms	ARG2 CRYAB CYP17A1 ARID2 TLR4 STEAP4 ZFHX3	1.53e-03	616	81	7	C0033578
Disease	Malignant neoplasm of prostate	ARG2 CRYAB CYP17A1 ARID2 TLR4 STEAP4 ZFHX3	1.53e-03	616	81	7	C0376358
Disease	Hepatitis, Chronic	ATP7A MKI67	1.66e-03	22	81	2	C0019189
Disease	Chronic active hepatitis	ATP7A MKI67	1.66e-03	22	81	2	C0520463
Disease	Cryptogenic Chronic Hepatitis	ATP7A MKI67	1.66e-03	22	81	2	C0524611
Disease	Chronic Persistent Hepatitis	ATP7A MKI67	1.66e-03	22	81	2	C0149519
Disease	osteoarthritis, hip	TLR4 HERC2 MAP2K6	2.10e-03	92	81	3	EFO_1000786
Disease	Glycogen Storage Disease	PYGL PFKM	2.50e-03	27	81	2	C0017919
Disease	HbA1c measurement	CDKN2C KL PKLR USP4 OXSR1 PFKM MYBPC3	2.56e-03	675	81	7	EFO_0004541
Disease	Alzheimer disease, age at onset	FAT1 ZNF813 SEC11C HERC2 F13A1	2.57e-03	343	81	5	EFO_0004847, MONDO_0004975
Disease	Malignant neoplasm of breast	CDKN2C CYP17A1 RPS6KA3 PRKAA1 RNF149 MKI67 ANKRD30A FAM131A HERC2	2.71e-03	1074	81	9	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
HSILKKSVHSVAVIG	ARG2	16	P78540
GDIIAILKHAKVVHR	C19orf47	96	Q8N9M1
LLENAKKHHVEVVGV	AZIN2	181	Q96A70
IERHIEHGGKTVEVK	ADAM22	116	Q9P0K1
KEATGLHVHERKIEV	ARID2	1251	Q68CP9
AKLLSHGAVIEVHNK	ANKRD30A	156	Q9BXX3
KVVQLLIEHGAVVDH	ANKRD50	1026	Q9ULJ7
GKVNGVHHIKVSLEE	ATP7A	31	Q04656
VKVLGDVIEVHGKHE	CRYAB	91	P02511
LVTVVHKDKAHSIGK	GUF1	566	Q8N442
HIVAKGEHKSGVLDE	OXSR1	106	O95747
EHKPSAVAHVVVKVI	FAT1	2056	Q14517
HVEGTIILHIVFAIK	FANCI	266	Q9NVI1
VDEAVAVLQAHHAKK	PABPC4	616	Q13310
PGSAIIHIKKHQVSV	MDC1	531	Q14676
HAVEEVVKEVVGHAK	FAM25G	26	B3EWG6
VVKKVAVHSGGRHAT	HERC2	3046	O95714
KHVLSGHTKGVLAAI	GLB1L3	261	Q8NCI6
HKVVHVVDKHILVFD	KIF18A	31	Q8NI77
SIKEIAITHHVKEGH	RPS6KA3	46	P51812
LGAKHCVKEVVEAHV	GATD3B	216	A0A0B4J2D5
HAVEEVVKEVVGHAK	FAM25A	26	B3EWG3
AIVSHEKNLVIAHEG	PCNX1	1881	Q96RV3
AVRHLGSKAEKHVHV	KIAA1586	166	Q9HCI6
ELAVVSLKGVHILQH	KPTN	381	Q9Y664
HHAAKTLGIGKAIAV	PFKM	6	P08237
SPVELKHVHATVVKV	NFIL3	301	Q16649
IVKDHIFKHGTVASR	CRLF3	166	Q8IUI8
LKILTGKIVVGHAIH	ISG20L2	251	Q9H9L3
HVVENVDATHIGKLI	F13A1	451	P00488
HGIKIISKIENHEGV	PKLR	306	P30613
VDAHVGKHIFNKVLG	ABCC2	791	Q92887
EDTKIHGVGFVKIHA	ANO1	146	Q5XXA6
TIIIGKAHTEKVHVP	MKI67	716	P46013
KKILHVDNHIGISIA	PSMA1	61	P25786
AKEGHLRVVEFLVKH	CDKN2C	111	P42773
AITVKVGHTAHIKVP	IGSF22	616	Q8N9C0
DIILRVGDVKIHAHK	KLHL28	36	Q9NXS3
VGDVKIHAHKVVLAS	KLHL28	41	Q9NXS3
KTTVIVGHHQLAKEV	CYP17A1	71	P05093
SLHGISQVVKDHVTK	FAM131A	106	Q6UXB0
HEKIVHILSNAVGEI	APBA1	801	Q02410
HLEEVKRHKVHISGT	GJB1	116	P08034
LGAKHCVKEVVEAHV	GATD3	216	P0DPI2
VHHSKRLIKVDGVVT	KL	551	Q9UEF7
PHHVDKLVTVGIKHI	EML6	826	Q6ZMW3
TIGHVAHGKSTVVKA	EIF2S3B	46	Q2VIR3
GVLVLDAVKHLTHAQ	EBP	201	Q15125
VKKGVKHVESILHLA	DNAH2	296	Q9P225
QKEVLVKVTHHGSHE	KIF28P	576	B7ZC32
ALVLIHGEVVHKSKQ	PHYHD1	236	Q5SRE7
YDGVVQTVKHIHVKA	PHF20	121	Q9BVI0
GKIAVSIVKALEHLH	MAP2K6	156	P52564
HAVEEVVKEVVGHAK	FAM25C	26	B3EWG5
HHKFAIVDKRVLITG	PLD6	156	Q8N2A8
IVHRVIKVHEKDNGD	SEC11C	106	Q9BY50
EKSLAGRVKHIVHQA	TCP11L2	96	Q8N4U5
SGVHVEVHDLLVDIK	NBEA	1046	Q8NFP9
VAGEHHILKATVALL	PKHD1	2121	P08F94
VKVGKHELTGHKVAV	PRKAA1	41	Q13131
KGHKAEVTAHEVAVS	AHNAK2	1276	Q8IVF2
HAAVLVETIKKGIHD	CLASP2	251	O75122
LLHTVKHGEKGIDVD	RNF149	251	Q8NC42
VVEHGLFVKHCKVEV	USP4	121	Q13107
SVLVIHKAVHTAEKP	ZNF320	286	A2RRD8
HKAVLHIGEKGTEAA	SERPINA7	351	P05543
SVHKVEPITKHIGLV	PSMA2	61	P25787
AKKSGIIIIAIHREH	STEAP4	71	Q687X5
GKHEAIVKNVHDLLA	USP9Y	441	O00507
KGKVIVIVGHVAKHT	TBCK	841	Q8TEA7
VKDRVVHAHIGVKEL	PTH2R	196	P49190
NSALVIHKAIHIGEK	ZNF813	451	Q6ZN06
HHGASVVVLEAALKI	TTC28	211	Q96AY4
CLDVFKEIIHKGHVV	PTCD1	266	O75127
HAVNGVAKIHSDIVK	PYGL	451	P06737
GFHKSRKVIVVVSQH	TLR4	726	O00206
LVKVIAHGKDHPTAA	PC	426	P11498
GVSVEVGKLVHKFHV	PPIP5K1	1341	Q6PFW1
LDHIAHEVGLKKRVV	ZFHX3	2671	Q15911
TIGHVAHGKSTVVKA	EIF2S3	46	P41091
KDEGVLKEISITHHV	RPS6KA1	36	Q15418
GVVKEIDISHHVKEG	RPS6KA2	36	Q15349
DVSVVVKGHAFKAHR	NACC1	31	Q96RE7
KVSHIGRVHKLTIDD	MYBPC3	591	Q14896