Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	non-membrane spanning protein tyrosine kinase activity	TYK2 YES1 SRC	2.87e-05	46	26	3	GO:0004715
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C SMYD2	7.29e-05	10	26	2	GO:0140999
GeneOntologyMolecularFunction	histone modifying activity	KMT2C CDY2A SMYD2 CDY1	2.07e-04	229	26	4	GO:0140993
GeneOntologyMolecularFunction	transcription corepressor activity	N4BP2L2 CDY2A CHD4 CDY1	2.07e-04	229	26	4	GO:0003714
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C SMYD2	3.05e-04	20	26	2	GO:0042800
GeneOntologyMolecularFunction	transcription coregulator activity	N4BP2L2 KMT2C CDY2A CHD4 CDY1	6.99e-04	562	26	5	GO:0003712
GeneOntologyMolecularFunction	protein tyrosine kinase activity	TYK2 YES1 SRC	8.63e-04	145	26	3	GO:0004713
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2C SMYD2	1.49e-03	44	26	2	GO:0140938
GeneOntologyMolecularFunction	histone acetyltransferase activity	CDY2A CDY1	2.00e-03	51	26	2	GO:0004402
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	CDY2A CDY1	2.32e-03	55	26	2	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	CDY2A CDY1	2.75e-03	60	26	2	GO:0034212
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	N4BP2L2 KMT2C CDY2A CHD4 SARM1 CDY1	3.20e-03	1160	26	6	GO:0030674
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2C SMYD2	3.52e-03	68	26	2	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2C SMYD2	3.63e-03	69	26	2	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	KMT2C SMYD2	3.83e-03	71	26	2	GO:0042054
GeneOntologyCellularComponent	asymmetric, glutamatergic, excitatory synapse	CHD4 ITGB1	4.04e-04	24	26	2	GO:0098985
GeneOntologyCellularComponent	postsynaptic specialization, intracellular component	YES1 SRC	2.20e-03	56	26	2	GO:0099091
GeneOntologyCellularComponent	cell division site	RTKN ITGB1	4.43e-03	80	26	2	GO:0032153
GeneOntologyCellularComponent	actin-based cell projection	TMC2 ITGB1 SRC	4.82e-03	278	26	3	GO:0098858
GeneOntologyCellularComponent	actin cytoskeleton	TNNI1 RTKN YES1 SRC	5.27e-03	576	26	4	GO:0015629
Domain	AHD	RTKN2 RTKN	5.59e-06	3	26	2	IPR012966
Domain	Anillin	RTKN2 RTKN	5.59e-06	3	26	2	PF08174
Domain	Chromo	CDY2A CHD4 CDY1	6.10e-06	26	26	3	PF00385
Domain	CHROMO_2	CDY2A CHD4 CDY1	7.67e-06	28	26	3	PS50013
Domain	CHROMO_1	CDY2A CHD4 CDY1	7.67e-06	28	26	3	PS00598
Domain	Chromodomain-like	CDY2A CHD4 CDY1	1.16e-05	32	26	3	IPR016197
Domain	CHROMO	CDY2A CHD4 CDY1	1.27e-05	33	26	3	SM00298
Domain	Chromo/shadow_dom	CDY2A CHD4 CDY1	1.27e-05	33	26	3	IPR000953
Domain	Hr1	RTKN2 RTKN	3.90e-05	7	26	2	SM00742
Domain	Chromo_dom_subgr	CDY2A CDY1	8.33e-05	10	26	2	IPR017984
Domain	TyrKc	TYK2 YES1 SRC	2.43e-04	88	26	3	SM00219
Domain	Tyr_kinase_cat_dom	TYK2 YES1 SRC	2.43e-04	88	26	3	IPR020635
Domain	Crotonase_core_superfam	CDY2A CDY1	2.50e-04	17	26	2	IPR001753
Domain	ECH_1	CDY2A CDY1	2.50e-04	17	26	2	PF00378
Domain	PROTEIN_KINASE_TYR	TYK2 YES1 SRC	3.24e-04	97	26	3	PS00109
Domain	Tyr_kinase_AS	TYK2 YES1 SRC	3.24e-04	97	26	3	IPR008266
Domain	SH2	TYK2 YES1 SRC	4.68e-04	110	26	3	SM00252
Domain	SH2	TYK2 YES1 SRC	4.81e-04	111	26	3	PS50001
Domain	SH2	TYK2 YES1 SRC	4.94e-04	112	26	3	IPR000980
Domain	-	TYK2 YES1 SRC	4.94e-04	112	26	3	3.30.505.10
Domain	HR1_rho-bd	RTKN2 RTKN	5.48e-04	25	26	2	IPR011072
Domain	Pkinase_Tyr	TYK2 YES1 SRC	7.45e-04	129	26	3	PF07714
Domain	Ser-Thr/Tyr_kinase_cat_dom	TYK2 YES1 SRC	9.06e-04	138	26	3	IPR001245
Domain	SET	KMT2C SMYD2	1.48e-03	41	26	2	PF00856
Domain	SET	KMT2C SMYD2	1.86e-03	46	26	2	SM00317
Domain	SET_dom	KMT2C SMYD2	2.19e-03	50	26	2	IPR001214
Domain	SET	KMT2C SMYD2	2.19e-03	50	26	2	PS50280
Domain	PH_dom-like	TYK2 DOK6 RTKN2 RTKN	2.68e-03	426	26	4	IPR011993
Domain	HMG_box_dom	KMT2C CHD4	3.67e-03	65	26	2	IPR009071
Domain	PH	DOK6 RTKN2 RTKN	3.84e-03	229	26	3	PF00169
Domain	PHD	KMT2C CHD4	4.86e-03	75	26	2	PF00628
Domain	Znf_PHD-finger	KMT2C CHD4	5.38e-03	79	26	2	IPR019787
Domain	PH	DOK6 RTKN2 RTKN	6.58e-03	278	26	3	SM00233
Domain	PH_DOMAIN	DOK6 RTKN2 RTKN	6.65e-03	279	26	3	PS50003
Domain	PH_domain	DOK6 RTKN2 RTKN	6.72e-03	280	26	3	IPR001849
Domain	PHD	KMT2C CHD4	6.77e-03	89	26	2	SM00249
Domain	Znf_PHD	KMT2C CHD4	7.07e-03	91	26	2	IPR001965
Domain	ZF_PHD_2	KMT2C CHD4	7.68e-03	95	26	2	PS50016
Domain	ZF_PHD_1	KMT2C CHD4	7.84e-03	96	26	2	PS01359
Domain	SH2	YES1 SRC	8.65e-03	101	26	2	PF00017
Pathway	WP_IL11_SIGNALING	TYK2 YES1 SRC	2.65e-05	44	19	3	M39716
Pathway	PID_PTP1B_PATHWAY	TYK2 YES1 SRC	4.40e-05	52	19	3	M50
Pathway	PID_FAK_PATHWAY	YES1 ITGB1 SRC	6.43e-05	59	19	3	M281
Pathway	WP_ALPHA_6_BETA_4_INTEGRIN_SIGNALING_PATHWAY	RTKN YES1 SRC	9.00e-05	66	19	3	MM15925
Pathway	REACTOME_PECAM1_INTERACTIONS	YES1 SRC	1.13e-04	12	19	2	MM14835
Pathway	REACTOME_PECAM1_INTERACTIONS	YES1 SRC	1.13e-04	12	19	2	M11773
Pathway	REACTOME_REGULATION_OF_KIT_SIGNALING	YES1 SRC	1.33e-04	13	19	2	MM14565
Pathway	REACTOME_REGULATION_OF_KIT_SIGNALING	YES1 SRC	2.04e-04	16	19	2	M537
Pathway	REACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE	YES1 SRC	2.60e-04	18	19	2	MM15023
Pathway	REACTOME_MET_ACTIVATES_PTK2_SIGNALING	ITGB1 SRC	2.90e-04	19	19	2	MM15512
Pathway	PID_CXCR4_PATHWAY	YES1 ITGB1 SRC	3.09e-04	100	19	3	M124
Pathway	REACTOME_SIGNALING_BY_KIT_IN_DISEASE	YES1 SRC	3.22e-04	20	19	2	M39002
Pathway	REACTOME_CTLA4_INHIBITORY_SIGNALING	YES1 SRC	3.56e-04	21	19	2	M5876
Pathway	REACTOME_CTLA4_INHIBITORY_SIGNALING	YES1 SRC	3.56e-04	21	19	2	MM14996
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	DOK6 YES1 ITGB1 SRC	3.57e-04	261	19	4	MM15676
Pathway	WP_NRF2ARE_REGULATION	YES1 SRC	4.28e-04	23	19	2	M39761
Pathway	PID_PRL_SIGNALING_EVENTS_PATHWAY	ITGB1 SRC	4.28e-04	23	19	2	M11
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGAP_RHOA_SIGNALING_PATHWAY	ITGB1 SRC	4.28e-04	23	19	2	M47537
Pathway	WP_GASTRIN_SIGNALING	YES1 ITGB1 SRC	4.66e-04	115	19	3	M39866
Pathway	REACTOME_RUNX2_REGULATES_OSTEOBLAST_DIFFERENTIATION	YES1 SRC	4.67e-04	24	19	2	M27803
Pathway	PID_INTEGRIN_A9B1_PATHWAY	ITGB1 SRC	5.07e-04	25	19	2	M118
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_CDC42_SIGNALING_PATHWAY	ITGB1 SRC	5.49e-04	26	19	2	M47719
Pathway	PID_GLYPICAN_1PATHWAY	YES1 SRC	5.92e-04	27	19	2	M33
Pathway	WP_NANOPARTICLEMEDIATED_ACTIVATION_OF_RECEPTOR_SIGNALING	ITGB1 SRC	6.37e-04	28	19	2	M39572
Pathway	REACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE	YES1 SRC	6.84e-04	29	19	2	M27309
Pathway	REACTOME_MET_ACTIVATES_PTK2_SIGNALING	ITGB1 SRC	7.32e-04	30	19	2	M27772
Pathway	PID_EPHRINB_REV_PATHWAY	YES1 SRC	7.32e-04	30	19	2	M257
Pathway	PID_P38_ALPHA_BETA_PATHWAY	YES1 SRC	7.32e-04	30	19	2	M76
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_RAC_SIGNALING_PATHWAY	ITGB1 SRC	7.32e-04	30	19	2	M47718
Pathway	REACTOME_MET_PROMOTES_CELL_MOTILITY	ITGB1 SRC	7.32e-04	30	19	2	MM15517
Pathway	REACTOME_SIGNALING_BY_CSF1_M_CSF_IN_MYELOID_CELLS	YES1 SRC	7.82e-04	31	19	2	M46423
Pathway	REACTOME_RUNX2_REGULATES_BONE_DEVELOPMENT	YES1 SRC	7.82e-04	31	19	2	M27805
Pathway	PID_NETRIN_PATHWAY	YES1 SRC	8.33e-04	32	19	2	M108
Pathway	PID_ALPHA_SYNUCLEIN_PATHWAY	YES1 SRC	8.33e-04	32	19	2	M275
Pathway	PID_SYNDECAN_2_PATHWAY	ITGB1 SRC	8.86e-04	33	19	2	M240
Pathway	PID_INTEGRIN_A4B1_PATHWAY	ITGB1 SRC	8.86e-04	33	19	2	M277
Pathway	REACTOME_CD28_CO_STIMULATION	YES1 SRC	8.86e-04	33	19	2	M11725
Pathway	PID_EPHA_FWDPATHWAY	YES1 SRC	9.41e-04	34	19	2	M177
Pathway	REACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS	YES1 SRC	9.41e-04	34	19	2	MM15025
Pathway	REACTOME_CD28_CO_STIMULATION	YES1 SRC	9.41e-04	34	19	2	MM14992
Pathway	WP_HEPATOCYTE_GROWTH_FACTOR_RECEPTOR_SIGNALING	ITGB1 SRC	9.41e-04	34	19	2	M39383
Pathway	REACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS	TYK2 CHD4 ITGB1	1.09e-03	154	19	3	M39007
Pathway	REACTOME_EPHB_MEDIATED_FORWARD_SIGNALING	YES1 SRC	1.11e-03	37	19	2	MM15022
Pathway	REACTOME_SIGNALING_BY_SCF_KIT	YES1 SRC	1.11e-03	37	19	2	MM14564
Pathway	REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL	YES1 ITGB1 SRC	1.17e-03	158	19	3	MM14812
Pathway	REACTOME_RET_SIGNALING	DOK6 SRC	1.18e-03	38	19	2	MM15493
Pathway	PID_RET_PATHWAY	DOK6 SRC	1.24e-03	39	19	2	M82
Pathway	REACTOME_RET_SIGNALING	DOK6 SRC	1.30e-03	40	19	2	M27746
Pathway	REACTOME_MET_PROMOTES_CELL_MOTILITY	ITGB1 SRC	1.37e-03	41	19	2	M27778
Pathway	PID_AMB2_NEUTROPHILS_PATHWAY	YES1 SRC	1.37e-03	41	19	2	M159
Pathway	REACTOME_EPHB_MEDIATED_FORWARD_SIGNALING	YES1 SRC	1.43e-03	42	19	2	M27308
Pathway	PID_UPA_UPAR_PATHWAY	ITGB1 SRC	1.43e-03	42	19	2	M174
Pathway	PID_TCPTP_PATHWAY	ITGB1 SRC	1.43e-03	42	19	2	M91
Pathway	REACTOME_SIGNALING_BY_SCF_KIT	YES1 SRC	1.50e-03	43	19	2	M508
Pathway	REACTOME_SIGNALING_BY_ERBB2	YES1 SRC	1.57e-03	44	19	2	MM14520
Pathway	REACTOME_GPER1_SIGNALING	ITGB1 SRC	1.65e-03	45	19	2	M45008
Pathway	WP_MECHANOREGULATION_AND_PATHOLOGY_OF_YAPTAZ_VIA_HIPPO_AND_NONHIPPO_MECHANISMS	ITGB1 SRC	1.79e-03	47	19	2	M39829
Pathway	WP_THYMIC_STROMAL_LYMPHOPOIETIN_TSLP_SIGNALING	YES1 SRC	1.79e-03	47	19	2	M39380
Pathway	PID_PI3KCI_PATHWAY	YES1 SRC	1.87e-03	48	19	2	M141
Pathway	REACTOME_FCGR_ACTIVATION	YES1 SRC	1.87e-03	48	19	2	MM17214
Pathway	WP_TROP2_REGULATORY_SIGNALING	ITGB1 SRC	1.95e-03	49	19	2	M46458
Pathway	REACTOME_SIGNALING_BY_ERBB2	YES1 SRC	2.03e-03	50	19	2	M553
Pathway	REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES	CHD4 YES1 ITGB1 SRC	2.07e-03	418	19	4	MM15587
Pathway	REACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS	YES1 SRC	2.11e-03	51	19	2	M27311
Pathway	REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL	YES1 ITGB1 SRC	2.11e-03	194	19	3	M16312
Pathway	PID_TXA2PATHWAY	YES1 SRC	2.54e-03	56	19	2	M99
Pathway	REACTOME_SIGNALING_BY_INTERLEUKINS	TYK2 YES1 ITGB1 IL37	3.25e-03	473	19	4	M874
Pathway	REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM	TYK2 YES1 ITGB1 IL37 SRC	3.27e-03	789	19	5	M1060
Pathway	WP_HISTONE_MODIFICATIONS	KMT2C SMYD2	3.40e-03	65	19	2	M39374
Pathway	REACTOME_EPH_EPHRIN_SIGNALING	YES1 SRC	3.40e-03	65	19	2	MM14911
Pathway	WP_ONCOSTATIN_M_SIGNALING	TYK2 SRC	3.40e-03	65	19	2	M39562
Pathway	REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY	YES1 SRC	3.51e-03	66	19	2	MM14990
Pathway	REACTOME_SIGNALING_BY_MET	ITGB1 SRC	3.61e-03	67	19	2	MM15345
Pathway	WP_RAC1PAK1P38MMP2_PATHWAY	ITGB1 SRC	3.72e-03	68	19	2	M39456
Pathway	REACTOME_L1CAM_INTERACTIONS	ITGB1 SRC	3.72e-03	68	19	2	MM14968
Pathway	REACTOME_FCGR_ACTIVATION	YES1 SRC	3.83e-03	69	19	2	M27108
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	KMT2C SMYD2	3.94e-03	70	19	2	M27231
Pathway	PID_CDC42_PATHWAY	YES1 SRC	3.94e-03	70	19	2	M81
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	DOK6 YES1 ITGB1 SRC	4.02e-03	502	19	4	MM14537
Pathway	WP_KIT_RECEPTOR_SIGNALING_PATHWAY	YES1 SRC	4.05e-03	71	19	2	MM15947
Pathway	WP_AXON_GUIDANCE	ITGB1 SRC	4.16e-03	72	19	2	M48335
Pathway	KEGG_ADHERENS_JUNCTION	YES1 SRC	4.27e-03	73	19	2	M638
Pathway	REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY	YES1 SRC	4.39e-03	74	19	2	M17386
Pathway	REACTOME_SIGNALING_BY_NTRKS	CHD4 SRC	4.50e-03	75	19	2	MM14652
Pathway	WP_PROLACTIN_SIGNALING	ITGB1 SRC	4.62e-03	76	19	2	M39601
Pathway	WP_REGULATORY_CIRCUITS_OF_STAT3_SIGNALING	TYK2 SRC	4.86e-03	78	19	2	M39824
Pathway	REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES	CHD4 YES1 ITGB1 SRC	4.95e-03	532	19	4	M27870
Pathway	REACTOME_SIGNALING_BY_MET	ITGB1 SRC	4.98e-03	79	19	2	M27643
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KMT2C CHD4 SMYD2	5.48e-03	272	19	3	M29619
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	DOK6 YES1 ITGB1 SRC	6.51e-03	575	19	4	M29853
Pathway	REACTOME_EPH_EPHRIN_SIGNALING	YES1 SRC	6.70e-03	92	19	2	M27201
Pubmed	Mammalian chromodomain proteins: their role in genome organisation and expression.	CDY2A CHD4 CDY1	2.07e-08	8	26	3	10655032
Pubmed	Integrin signalling regulates YAP and TAZ to control skin homeostasis.	YES1 ITGB1 SRC	1.68e-07	15	26	3	26989177
Pubmed	Elevated c-Src and c-Yes expression in malignant skin cancers.	YES1 SRC	5.37e-07	2	26	2	20796316
Pubmed	Ouabain stimulates a Na+/K+-ATPase-mediated SFK-activated signalling pathway that regulates tight junction function in the mouse blastocyst.	YES1 SRC	5.37e-07	2	26	2	21901128
Pubmed	Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice.	YES1 SRC	5.37e-07	2	26	2	7507074
Pubmed	The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo.	YES1 SRC	5.37e-07	2	26	2	10549294
Pubmed	Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells.	YES1 SRC	5.37e-07	2	26	2	21390316
Pubmed	Src family kinases are required for integrin but not PDGFR signal transduction.	YES1 SRC	1.61e-06	3	26	2	10228160
Pubmed	Localized activation of Src-family protein kinases in the mouse egg.	YES1 SRC	1.61e-06	3	26	2	17449027
Pubmed	Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.	YES1 SRC	1.61e-06	3	26	2	7958873
Pubmed	Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein.	YES1 SRC	1.61e-06	3	26	2	23497302
Pubmed	Src, Fyn and Yes play differential roles in VEGF-mediated endothelial cell events.	YES1 SRC	1.61e-06	3	26	2	16400523
Pubmed	Requirement of SRC-family tyrosine kinases in fat accumulation.	YES1 SRC	1.61e-06	3	26	2	16262245
Pubmed	Cellular tension encodes local Src-dependent differential β1 and β3 integrin mobility.	ITGB1 SRC	1.61e-06	3	26	2	30462575
Pubmed	Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake.	YES1 SRC	1.61e-06	3	26	2	20080640
Pubmed	Fibronectin induces endothelial cell migration through β1 integrin and Src-dependent phosphorylation of fibroblast growth factor receptor-1 at tyrosines 653/654 and 766.	ITGB1 SRC	1.61e-06	3	26	2	22247553
Pubmed	Entry of Neisseria meningitidis into mammalian cells requires the Src family protein tyrosine kinases.	YES1 SRC	1.61e-06	3	26	2	20176789
Pubmed	Accumulation of tissue factor in endothelial cells promotes cellular apoptosis through over-activation of Src1 and involves β1-integrin signalling.	ITGB1 SRC	1.61e-06	3	26	2	31654241
Pubmed	Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli.	ITGB1 SRC	1.61e-06	3	26	2	17630833
Pubmed	Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability.	YES1 SRC	1.61e-06	3	26	2	10635317
Pubmed	B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms.	ITGB1 SRC	1.61e-06	3	26	2	18322799
Pubmed	CD44 engagement promotes matrix-derived survival through the CD44-SRC-integrin axis in lipid rafts.	ITGB1 SRC	1.61e-06	3	26	2	18644869
Pubmed	Caveolin-1 contributes to anoikis resistance in human gastric cancer SGC-7901 cells via regulating Src-dependent EGFR-ITGB1 signaling.	ITGB1 SRC	3.22e-06	4	26	2	30088837
Pubmed	Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics.	ITGB1 SRC	3.22e-06	4	26	2	21045155
Pubmed	Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.	YES1 SRC	3.22e-06	4	26	2	7681396
Pubmed	GP2, a GPI-anchored protein in the apical plasma membrane of the pancreatic acinar cell, co-immunoprecipitates with src kinases and caveolin.	YES1 SRC	3.22e-06	4	26	2	11039464
Pubmed	A unique role for Fyn in CNS myelination.	YES1 SRC	3.22e-06	4	26	2	11245687
Pubmed	Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase.	YES1 SRC	3.22e-06	4	26	2	7537495
Pubmed	Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics.	YES1 SRC	3.22e-06	4	26	2	25080486
Pubmed	Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain.	YES1 SRC	3.22e-06	4	26	2	19258394
Pubmed	Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase.	ITGB1 SRC	3.22e-06	4	26	2	19470583
Pubmed	FAK-dependent regulation of myofibroblast differentiation.	YES1 SRC	3.22e-06	4	26	2	16585062
Pubmed	Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation.	YES1 SRC	3.22e-06	4	26	2	25157176
Pubmed	Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src.	YES1 SRC	3.22e-06	4	26	2	11127814
Pubmed	Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells.	YES1 SRC	3.22e-06	4	26	2	7521304
Pubmed	The Stiffness of Cardiac Fibroblast Substrates Exerts a Regulatory Influence on Collagen Metabolism via α2β1 Integrin, FAK and Src Kinases.	ITGB1 SRC	3.22e-06	4	26	2	34944014
Pubmed	A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males.	CDY2A CDY1	3.22e-06	4	26	2	9806824
Pubmed	State and role of SRC family kinases in replication of herpes simplex virus 1.	YES1 SRC	3.22e-06	4	26	2	16537602
Pubmed	Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation.	ITGB1 SRC	3.22e-06	4	26	2	16882656
Pubmed	Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases.	YES1 SRC	3.22e-06	4	26	2	14559149
Pubmed	Identification and characterization of the cynomolgus monkey chromodomain gene cynCDY, an orthologue of the human CDY gene family.	CDY2A CDY1	3.22e-06	4	26	2	12149400
Pubmed	Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation.	ITGB1 SRC	3.22e-06	4	26	2	19887442
Pubmed	Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch.	ITGB1 SRC	3.22e-06	4	26	2	14691141
Pubmed	Palatal adhesion is dependent on Src family kinases and p38MAPK.	YES1 SRC	5.37e-06	5	26	2	25354453
Pubmed	Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases.	YES1 SRC	5.37e-06	5	26	2	12846735
Pubmed	p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.	YES1 SRC	5.37e-06	5	26	2	17254967
Pubmed	Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits.	YES1 SRC	5.37e-06	5	26	2	18483622
Pubmed	Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.	YES1 SRC	5.37e-06	5	26	2	18194650
Pubmed	Type I collagen synergistically enhances PDGF-induced smooth muscle cell proliferation through pp60src-dependent crosstalk between the alpha2beta1 integrin and PDGFbeta receptor.	ITGB1 SRC	5.37e-06	5	26	2	15522237
Pubmed	S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH.	RTKN SRC	5.37e-06	5	26	2	19147496
Pubmed	Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells.	YES1 SRC	5.37e-06	5	26	2	22971575
Pubmed	Cyclic stretch-induced TGF-β1 and fibronectin expression is mediated by β1-integrin through c-Src- and STAT3-dependent pathways in renal epithelial cells.	ITGB1 SRC	5.37e-06	5	26	2	25477471
Pubmed	Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome.	CDY2A CDY1	5.37e-06	5	26	2	10192397
Pubmed	TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling.	YES1 SRC	5.37e-06	5	26	2	18255094
Pubmed	The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements.	YES1 SRC	5.37e-06	5	26	2	17623777
Pubmed	Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells.	YES1 SRC	5.37e-06	5	26	2	12509223
Pubmed	A gp130-Src-YAP module links inflammation to epithelial regeneration.	YES1 SRC	5.37e-06	5	26	2	25731159
Pubmed	Vav2 is required for cell spreading.	YES1 SRC	5.37e-06	5	26	2	11448999
Pubmed	Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac.	YES1 SRC	5.37e-06	5	26	2	10844001
Pubmed	VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration.	YES1 SRC	5.37e-06	5	26	2	21233420
Pubmed	Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration.	YES1 SRC	8.05e-06	6	26	2	19420001
Pubmed	Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.	YES1 SRC	8.05e-06	6	26	2	20606012
Pubmed	Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities.	YES1 SRC	8.05e-06	6	26	2	15557335
Pubmed	Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis.	YES1 SRC	8.05e-06	6	26	2	10861086
Pubmed	Slit2/Robo4 signaling modulates HIV-1 gp120-induced lymphatic hyperpermeability.	ITGB1 SRC	8.05e-06	6	26	2	22241990
Pubmed	Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.	YES1 SRC	8.05e-06	6	26	2	12923167
Pubmed	Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.	YES1 SRC	8.05e-06	6	26	2	9799234
Pubmed	Yes and PI3K bind CD95 to signal invasion of glioblastoma.	YES1 SRC	8.05e-06	6	26	2	18328427
Pubmed	ANG II-induced cell proliferation is dually mediated by c-Src/Yes/Fyn-regulated ERK1/2 activation in the cytoplasm and PKCzeta-controlled ERK1/2 activity within the nucleus.	YES1 SRC	8.05e-06	6	26	2	16723512
Pubmed	Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells.	YES1 SRC	8.05e-06	6	26	2	2404338
Pubmed	Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells.	YES1 SRC	8.05e-06	6	26	2	1381360
Pubmed	The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility.	YES1 SRC	8.05e-06	6	26	2	21725358
Pubmed	Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development.	YES1 SRC	1.13e-05	7	26	2	12526739
Pubmed	Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region.	YES1 SRC	1.13e-05	7	26	2	9632142
Pubmed	Direct reprogramming of stem cell properties in colon cancer cells by CD44.	ITGB1 SRC	1.13e-05	7	26	2	21701559
Pubmed	Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.	YES1 SRC	1.13e-05	7	26	2	12538589
Pubmed	CMS: an adapter molecule involved in cytoskeletal rearrangements.	YES1 SRC	1.13e-05	7	26	2	10339567
Pubmed	Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin.	YES1 SRC	1.13e-05	7	26	2	12558988
Pubmed	The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation.	YES1 SRC	1.13e-05	7	26	2	10829062
Pubmed	QM, a putative tumor suppressor, regulates proto-oncogene c-yes.	YES1 SRC	1.13e-05	7	26	2	12138090
Pubmed	Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis.	YES1 SRC	1.13e-05	7	26	2	19267251
Pubmed	Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases.	YES1 SRC	1.13e-05	7	26	2	10858437
Pubmed	Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes.	ITGB1 SRC	1.50e-05	8	26	2	22402981
Pubmed	The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation.	YES1 SRC	1.50e-05	8	26	2	21309750
Pubmed	Phosphorylation of SOCS1 Inhibits the SOCS1-p53 Tumor Suppressor Axis.	YES1 SRC	1.50e-05	8	26	2	31101761
Pubmed	p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.	YES1 SRC	1.50e-05	8	26	2	12640114
Pubmed	The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association.	YES1 SRC	1.50e-05	8	26	2	20605918
Pubmed	Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation.	YES1 SRC	1.50e-05	8	26	2	15190072
Pubmed	STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family.	YES1 SRC	1.50e-05	8	26	2	8918464
Pubmed	Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression.	YES1 SRC	1.50e-05	8	26	2	21829547
Pubmed	Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis.	YES1 SRC	1.50e-05	8	26	2	16921024
Pubmed	Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β.	ITGB1 SRC	1.50e-05	8	26	2	24036928
Pubmed	Identification of a new adapter protein that may link the common beta subunit of the receptor for granulocyte/macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 to phosphatidylinositol 3-kinase.	YES1 SRC	1.50e-05	8	26	2	7499252
Pubmed	Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis.	CDY2A CDY1	1.50e-05	8	26	2	12072557
Pubmed	Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit.	YES1 SRC	1.93e-05	9	26	2	18697750
Pubmed	Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons.	YES1 SRC	2.41e-05	10	26	2	15062102
Pubmed	Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes.	YES1 SRC	2.41e-05	10	26	2	18155796
Pubmed	The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons.	YES1 SRC	2.41e-05	10	26	2	16687575
Pubmed	SRC family kinases are required for limb trajectory selection by spinal motor axons.	YES1 SRC	2.94e-05	11	26	2	19403835
Pubmed	Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors.	YES1 SRC	2.94e-05	11	26	2	11312300
Interaction	CD46 interactions	YES1 ITGB1 SRC	1.27e-05	37	25	3	int:CD46
Interaction	CD36 interactions	YES1 ITGB1 SRC	1.50e-05	39	25	3	int:CD36
Interaction	KMT2A interactions	KMT2C CHD4 YES1 ITGB1 SRC	3.66e-05	314	25	5	int:KMT2A
Interaction	EDNRA interactions	SMPD2 YES1 SRC	3.79e-05	53	25	3	int:EDNRA
Interaction	H3C14 interactions	KMT2C CHAF1B CHD4 SMYD2	3.85e-05	156	25	4	int:H3C14
Interaction	DOK1 interactions	YES1 ITGB1 SRC	5.24e-05	59	25	3	int:DOK1
Interaction	NMRK2 interactions	LRP12 ITGB1	5.29e-05	9	25	2	int:NMRK2
Interaction	IGSF9B interactions	YES1 SRC	6.61e-05	10	25	2	int:IGSF9B
Interaction	H4C6 interactions	CHAF1B CHD4 SRC	8.37e-05	69	25	3	int:H4C6
Interaction	PTPRC interactions	TYK2 ITGB1 SRC	8.37e-05	69	25	3	int:PTPRC
Interaction	CSF1R interactions	TYK2 YES1 SRC	1.07e-04	75	25	3	int:CSF1R
Interaction	ACBD7 interactions	YES1 SRC	1.33e-04	14	25	2	int:ACBD7
Cytoband	Ensembl 112 genes in cytogenetic band chr1q32	TNNI1 SMYD2	1.17e-02	290	26	2	chr1q32
Cytoband	Ensembl 112 genes in cytogenetic band chrYq11	CDY2A CDY1	1.34e-02	311	26	2	chrYq11
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C SMYD2	5.75e-04	34	19	2	487
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DOK6 RTKN2 RTKN	1.23e-03	206	19	3	682
GeneFamily	PHD finger proteins	KMT2C CHD4	3.97e-03	90	19	2	88
GeneFamily	SH2 domain containing	YES1 SRC	4.97e-03	101	19	2	741
ToppCell	droplet-Spleen-nan-24m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAF1B TNNI1 RTKN SARM1	3.77e-06	184	26	4	b998803180322a5ea2b567928dea531c26816c3c
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	N4BP2L2 KMT2C RTKN2 TNNI1	4.94e-06	197	26	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
Drug	dinitrophenyl-human serum albumin conjugate	TYK2 SRC	4.49e-05	9	26	2	ctd:C058064
Drug	27-hydroxycholesterol	SMPD2 ITGB1 SRC	4.78e-05	62	26	3	ctd:C076996
Drug	Dasatinib	YES1 SRC	5.61e-05	10	26	2	DB01254
Drug	ponatinib	TYK2 YES1 SRC	6.31e-05	68	26	3	ctd:C545373
Drug	Azacyclonol [115-46-8]; Down 200; 15uM; PC3; HG-U133A	N4BP2L2 LRP12 CHAF1B YES1	6.34e-05	192	26	4	1937_DN
Drug	AC1L1J0H	TYK2 YES1 ITGB1 SRC	7.00e-05	197	26	4	CID000004813
Drug	Diphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; PC3; HT_HG-U133A	SMPD2 CHD4 ITGB1 SARM1	7.14e-05	198	26	4	1830_DN
Drug	Canavanine sulfate monohydrate (L,+) [206996-57-8]; Up 200; 13.6uM; MCF7; HT_HG-U133A	LRP12 SMPD2 SARM1 SRC	7.14e-05	198	26	4	4782_UP
Drug	Flumethasone [2135-17-3]; Down 200; 9.8uM; MCF7; HT_HG-U133A	LRP12 SMPD2 ITGB1 SRC	7.28e-05	199	26	4	3410_DN
Disease	interferon alpha/beta receptor 1 measurement	TYK2 SARM1	2.27e-05	9	24	2	EFO_0021850
Disease	Spermatogenic Failure, Nonobstructive, Y-Linked	CDY2A CDY1	7.56e-05	16	24	2	C1839071
Disease	SPERMATOGENIC FAILURE, Y-LINKED, 2	CDY2A CDY1	7.56e-05	16	24	2	415000
Disease	Spermatogenic failure, Y-linked, 2	CDY2A CDY1	7.56e-05	16	24	2	cv:C1839071
Disease	colon adenocarcinoma (is_implicated_in)	CHD4 SRC	2.04e-04	26	24	2	DOID:234 (is_implicated_in)
Disease	colorectal cancer (implicated_via_orthology)	YES1 SRC	2.72e-04	30	24	2	DOID:9256 (implicated_via_orthology)
Disease	intestinal cancer (implicated_via_orthology)	YES1 SRC	3.10e-04	32	24	2	DOID:10155 (implicated_via_orthology)
Disease	kidney disease (implicated_via_orthology)	YES1 SRC	5.10e-04	41	24	2	DOID:557 (implicated_via_orthology)
Disease	nasopharynx carcinoma (is_marker_for)	KMT2C SRC	5.61e-04	43	24	2	DOID:9261 (is_marker_for)
Disease	lung adenocarcinoma (is_implicated_in)	KMT2C CHD4	7.28e-04	49	24	2	DOID:3910 (is_implicated_in)
Disease	carcinoma (implicated_via_orthology)	YES1 SRC	1.24e-03	64	24	2	DOID:305 (implicated_via_orthology)
Disease	cancer (implicated_via_orthology)	YES1 ITGB1 SRC	1.30e-03	268	24	3	DOID:162 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WPACAQKIMDHVEES	BRAT1	191	Q6PJG6
DTWEPEQHLMNCEKC	CDY1	36	Q9Y6F8
DTWEPEQHLMNCEKC	CDY2A	36	Q9Y6F7
MVKGKDEWDIPHICN	GSDMA	211	Q96QA5
MKVITCEIAWHNKEP	CHAF1B	1	Q13112
DPVSHCKEKDVDDCW	ITGB1	686	P05556
NMCKRWVHLECDKPT	KMT2C	486	Q8NEZ4
GKCIPEAWKCNNMDE	LRP12	176	Q9Y561
SEWLKGCDMHVKIDP	SPACA5	141	Q96QH8
MHPEDLGCCLLKEWT	SMPD2	181	O60906
EERWMKEDCTHCICE	PXDNL	1406	A1KZ92
KMGSEDWEKDEPQCC	IL37	11	Q9NZH6
SELEAEEWCKHLCME	DOK6	96	Q6PKX4
CPHCEKEGIQWEAKE	CHD4	411	Q14839
SQWKHCCEELMKIEI	RTKN2	396	Q8IZC4
WKQCCDEIMKIETPA	RTKN	421	Q9BST9
PESLHDLMCQCWRKE	SRC	491	P12931
CLEQEKEPWNMKRHE	ZNF431	86	Q8TF32
LDKCMQDHDCKDWVH	SARM1	626	Q6SZW1
LMLAKAKECWEQEHE	TNNI1	21	P19237
HFMELCWDKCVEKPG	TIMM8B	31	Q9Y5J9
CIPWEMKIKDIESHF	TMC2	231	Q8TDI7
VECQKEDWPMHKLEC	SMYD2	76	Q9NRG4
PCEVYHLMKNCWETE	TYK2	1141	P29597
LHELMNLCWKKDPDE	YES1	501	P07947
CEVRERCWKDHCMDK	N4BP2L2	366	Q92802