Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Homeobox_CS	ZFHX3 HOXC11 IRX2 HOXA2	2.43e-04	186	31	4	IPR017970
Domain	Homeobox	ZFHX3 HOXC11 IRX2 HOXA2	5.79e-04	234	31	4	PF00046
Domain	HOMEOBOX_1	ZFHX3 HOXC11 IRX2 HOXA2	5.98e-04	236	31	4	PS00027
Domain	HOX	ZFHX3 HOXC11 IRX2 HOXA2	6.08e-04	237	31	4	SM00389
Domain	Homeobox_dom	ZFHX3 HOXC11 IRX2 HOXA2	6.27e-04	239	31	4	IPR001356
Domain	HOMEOBOX_2	ZFHX3 HOXC11 IRX2 HOXA2	6.27e-04	239	31	4	PS50071
Domain	ZnF_U1	ZFHX3 ZNF830	1.05e-03	29	31	2	SM00451
Domain	Znf_U1	ZFHX3 ZNF830	1.05e-03	29	31	2	IPR003604
Domain	-	ZFHX3 HOXC11 IRX2 HOXA2	1.18e-03	283	31	4	1.10.10.60
Domain	Homeodomain-like	ZFHX3 HOXC11 IRX2 HOXA2	2.11e-03	332	31	4	IPR009057
Domain	Homeobox_metazoa	HOXC11 HOXA2	9.75e-03	90	31	2	IPR020479
Domain	-	DOT1L TGS1	1.69e-02	120	31	2	3.40.50.150
Domain	SAM-dependent_MTases	DOT1L TGS1	1.74e-02	122	31	2	IPR029063
Pubmed	DOT1L Activity Promotes Proliferation and Protects Cortical Neural Stem Cells from Activation of ATF4-DDIT3-Mediated ER Stress In Vitro.	ATF4 DOT1L	2.46e-06	3	32	2	26299268
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	MPDZ DOT1L MAP1B CBL PRRC2B VCPIP1	9.62e-06	549	32	6	38280479
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PSD3 NOLC1 MPDZ CEP131 MAP1B CBL VCPIP1	1.09e-05	861	32	7	36931259
Pubmed	A census of human transcription factors: function, expression and evolution.	ZFHX3 ATF4 HOXC11 SOX8 IRX2 ZC3H3 HOXA2	1.54e-05	908	32	7	19274049
Pubmed	Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo.	HOXC11 HOXA2	1.72e-05	7	32	2	19716816
Pubmed	Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1.	HOXC11 HOXA2	3.67e-05	10	32	2	26496426
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	ATF4 DOT1L CBL ZC3H3 PRRC2B	5.35e-05	450	32	5	16751776
Pubmed	Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.	CEP131 MAP1B	5.38e-05	12	32	2	24089205
Pubmed	SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.	ATF4 HOXA2	6.36e-05	13	32	2	16751105
Pubmed	Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.	DNAI1 VCPIP1	7.41e-05	14	32	2	12509440
Pubmed	Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.	PSD3 TGS1	9.76e-05	16	32	2	12097419
Pubmed	Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.	HOXC11 CBL VCPIP1	1.28e-04	106	32	3	18654987
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TNRC18 DOT1L VCPIP1	1.32e-04	107	32	3	11347906
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	CEP131 MAP1B CBL	2.45e-04	132	32	3	16944949
Pubmed	Fine mapping of human HOX gene clusters.	HOXC11 HOXA2	2.63e-04	26	32	2	8646877
Pubmed	Human transcription factor protein interaction networks.	NOLC1 ZFHX3 CEP131 HOXC11 DOT1L RPA1 PRRC2B	2.66e-04	1429	32	7	35140242
Pubmed	The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development.	ZFHX3 IRX2	3.05e-04	28	32	2	32868762
Pubmed	Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons.	ZFHX3 SOX8	3.28e-04	29	32	2	31491374
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CXXC5 ARHGAP6 CHCHD6 ZFHX3 TNRC18 MAP1B CCDC57	3.41e-04	1489	32	7	28611215
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CEP131 TNRC18 MAP1B CBL PRRC2B	3.89e-04	689	32	5	36543142
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	PSD3 MPDZ MAP1B RPA1 VCPIP1	4.40e-04	708	32	5	39231216
Pubmed	Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.	ATF4 MAP1B	4.52e-04	34	32	2	25915474
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	TNRC18 DOT1L RPA1 HOXA2	4.71e-04	398	32	4	35016035
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	PSD3 NOLC1 CEP131 TNRC18 MAP1B VCPIP1	5.32e-04	1139	32	6	36417873
Pubmed	Atlas of Hox gene expression in the developing kidney.	HOXC11 HOXA2	5.65e-04	38	32	2	15042701
Pubmed	Complete mutation analysis panel of the 39 human HOX genes.	HOXC11 HOXA2	5.65e-04	38	32	2	11857506
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZFHX3 CEP131 SOX8 VCPIP1	5.67e-04	418	32	4	34709266
Pubmed	Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster.	HOXC11 HOXA2	5.95e-04	39	32	2	33257809
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	CEP131 MAP1B RPA1	6.25e-04	182	32	3	31067453
Pubmed	Quantification of Hox and surfactant protein-B transcription during murine lung development.	HOXC11 HOXA2	6.26e-04	40	32	2	19204410
Pubmed	Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates.	HOXC11 HOXA2	6.58e-04	41	32	2	32479258
Pubmed	Proteomic identification of brain proteins that interact with dynein light chain LC8.	MAP1B CLIP2	6.90e-04	42	32	2	14760703
Pubmed	Reduction of Hox gene expression by histone H1 depletion.	HOXC11 HOXA2	7.23e-04	43	32	2	22701719
Pubmed	Vertebrate homeobox gene nomenclature.	HOXC11 HOXA2	8.64e-04	47	32	2	1358459
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	PSD3 MPDZ CHCHD6 PRRC2B	9.12e-04	475	32	4	31040226
GeneFamily	HOXL subclass homeoboxes	HOXC11 HOXA2	1.65e-03	52	21	2	518
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PSD3 ARHGAP6 TNRC18 CCDC57 ZC3H3	2.94e-07	199	32	5	bbb4798d6a24e756fea744a151ba67c1bafbac9a
Disease	sphingomyelin 14:0 measurement	ZFHX3 IRX2	1.44e-04	17	31	2	EFO_0010390
Disease	body surface area	CXXC5 TICRR ZFHX3 DOT1L RPA1	5.14e-04	643	31	5	EFO_0022196
Disease	body fat percentage	ZFHX3 RPA1 ZC3H3 PRRC2B	1.63e-03	488	31	4	EFO_0007800
Disease	Lung diseases	DNAI1 IRX2	3.05e-03	78	31	2	C0024115
Disease	mean corpuscular hemoglobin concentration	PSD3 TICRR ATF4 DOT1L RPA1	5.51e-03	1105	31	5	EFO_0004528
Disease	S-6-hydroxywarfarin measurement	ZFHX3 SOX8 ZC3H3	6.68e-03	368	31	3	EFO_0803326
Disease	velopharyngeal dysfunction	MPDZ ARHGAP6	7.29e-03	122	31	2	EFO_0009336

Protein segments in the cluster

Peptide	Gene	Start	Entry
PHGFSSDKAKAGSSE	ATF4	46	P18848
SAAVAASSKEGSPLH	CLIP2	31	Q9UDT6
SFCSSAKSGKHSDPV	DNAI1	421	Q9UI46
TGAGSAKQSPSSKHS	DOT1L	1051	Q8TEK3
ASAGKKASSAAAPHT	DGAT1	226	O75907
APKIANGKAASSSSS	NOLC1	206	Q14978
ASASKSAKTATAGPG	MAP1B	2326	P46821
AAAVDHSGLPASASK	KIAA1549L	356	Q6ZVL6
ASALAVAPSAKAHKS	GPR35	286	Q9HC97
AVDKSNPTSKHKSGA	CXXC5	126	Q7LFL8
LHTAPKAASDAGKAG	IRX2	421	Q9BZI1
PASSSAASAKGFSKR	ARHGAP6	16	O43182
ASKTFGKAAGPSLSH	RPA1	161	P27694
AAQAKAKTTGASRSH	CCDC57	881	Q2TAC2
AKTTGASRSHPAKAK	CCDC57	886	Q2TAC2
SGSAHSVAKEPAKGA	HOXC11	211	O43248
AGKPSAAAASVSTQH	HGSNAT	121	Q68CP4
LGTASKAASGSLHKD	CBL	516	P22681
FGKLPKNVSSATHSA	CEP131	226	Q9UPN4
AATAAATGPACLSHK	HOXA2	116	O43364
AATKHSKASLPTGEG	CHCHD6	111	Q9BRQ6
RKSAKAGHSDSDSGA	SOX8	176	P57073
APHASSLTAAKRSKA	TNRC18	2076	O15417
KSGTSPAATAKSHLS	ZC3H3	461	Q8IXZ2
AAFKESLKDSSSPGH	TICRR	1151	Q7Z2Z1
PSAAGAASGEKKNSS	MPDZ	1571	O75970
AAHASADLPEASSKK	PRRC2B	1496	Q5JSZ5
LKSKAEGGQSAAAHS	VCPIP1	851	Q96JH7
GSSASSAPHSVKRKA	ZNF830	91	Q96NB3
KSSGANTSKDRPHAS	TGS1	391	Q96RS0
SAAHLGKLSKSTAPG	TRANK1	616	O15050
SEAAGLKKSHSSPSL	PSD3	1001	Q9NYI0
SAAAPSSASPHASRK	ZFHX3	3601	Q15911