Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	antigen binding	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6 IGHV3-73	1.32e-04	190	82	6	GO:0003823
GeneOntologyCellularComponent	IgG immunoglobulin complex	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6	1.50e-09	14	81	5	GO:0071735
GeneOntologyCellularComponent	IgD immunoglobulin complex	IGLC7 IGLC1 IGLC3 IGLC6	3.12e-09	6	81	4	GO:0071738
GeneOntologyCellularComponent	IgE immunoglobulin complex	IGLC7 IGLC1 IGLC3 IGLC6	3.12e-09	6	81	4	GO:0071742
GeneOntologyCellularComponent	IgA immunoglobulin complex	IGLC7 IGLC1 IGLC3 IGLC6	2.76e-07	15	81	4	GO:0071745
GeneOntologyCellularComponent	IgM immunoglobulin complex	IGLC7 IGLC1 IGLC3 IGLC6	2.76e-07	15	81	4	GO:0071753
GeneOntologyCellularComponent	trans-Golgi network	CLTCL1 ATP8A1 ARFGEF2 AP1M2 ARFGEF1 SCAMP3 COG5 DOP1A	2.45e-05	306	81	8	GO:0005802
GeneOntologyCellularComponent	clathrin coat of trans-Golgi network vesicle	SYNRG CLTCL1 AP1M2	4.39e-05	18	81	3	GO:0030130
GeneOntologyCellularComponent	immunoglobulin complex	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6 IGHV3-73	4.54e-05	166	81	6	GO:0019814
GeneOntologyCellularComponent	Golgi apparatus subcompartment	CLTCL1 ATP8A1 ARFGEF2 AP1M2 ARFGEF1 SCAMP3 COG5 B4GALT5 DOP1A	5.38e-05	443	81	9	GO:0098791
GeneOntologyCellularComponent	trans-Golgi network transport vesicle membrane	SYNRG CLTCL1 AP1M2	8.18e-05	22	81	3	GO:0012510
GeneOntologyCellularComponent	Golgi membrane	ARHGAP32 CHST15 EGFR USP32 ARFGEF2 AP1M2 ARFGEF1 SCAMP3 COG5 B4GALT5 DOP1A	1.03e-04	721	81	11	GO:0000139
GeneOntologyCellularComponent	clathrin-coated vesicle membrane	SYNRG CLTCL1 EGFR AP1M2 APOB	2.68e-04	147	81	5	GO:0030665
GeneOntologyCellularComponent	clathrin vesicle coat	SYNRG CLTCL1 AP1M2	4.29e-04	38	81	3	GO:0030125
GeneOntologyCellularComponent	trans-Golgi network transport vesicle	SYNRG CLTCL1 AP1M2	4.99e-04	40	81	3	GO:0030140
GeneOntologyCellularComponent	AP-1 adaptor complex	SYNRG AP1M2	9.54e-04	12	81	2	GO:0030121
GeneOntologyCellularComponent	Golgi-associated vesicle	SYNRG CLTCL1 AP1M2 DOP1A	1.01e-03	114	81	4	GO:0005798
GeneOntologyCellularComponent	clathrin coat	SYNRG CLTCL1 AP1M2	1.34e-03	56	81	3	GO:0030118
GeneOntologyCellularComponent	coated vesicle membrane	SYNRG CLTCL1 EGFR AP1M2 APOB	1.49e-03	215	81	5	GO:0030662
GeneOntologyCellularComponent	radial spoke	RSPH4A CFAP61	1.51e-03	15	81	2	GO:0001534
GeneOntologyCellularComponent	Golgi-associated vesicle membrane	SYNRG CLTCL1 AP1M2	1.72e-03	61	81	3	GO:0030660
GeneOntologyCellularComponent	low-density lipoprotein particle	PLA2G7 APOB	1.72e-03	16	81	2	GO:0034362
GeneOntologyCellularComponent	vesicle coat	SYNRG CLTCL1 AP1M2	2.25e-03	67	81	3	GO:0030120
GeneOntologyCellularComponent	clathrin-coated vesicle	SYNRG CLTCL1 EGFR AP1M2 APOB	2.29e-03	237	81	5	GO:0030136
Domain	DUF1981	ARFGEF2 ARFGEF1	9.24e-05	4	74	2	PF09324
Domain	HJURP_C	HJURP MEF2A	9.24e-05	4	74	2	IPR022102
Domain	HJURP_C	HJURP MEF2A	9.24e-05	4	74	2	PF12347
Domain	Sec7_N	ARFGEF2 ARFGEF1	9.24e-05	4	74	2	IPR032691
Domain	Sec7_N	ARFGEF2 ARFGEF1	9.24e-05	4	74	2	PF12783
Domain	DCB_dom	ARFGEF2 ARFGEF1	9.24e-05	4	74	2	IPR032629
Domain	DCB	ARFGEF2 ARFGEF1	9.24e-05	4	74	2	PF16213
Domain	Sec7_C	ARFGEF2 ARFGEF1	9.24e-05	4	74	2	IPR015403
Domain	TRP_channel	TRPV1 TRPC7	8.32e-04	11	74	2	IPR004729
Domain	Ion_trans_dom	TRPV1 TRPC7 KCNQ4 TRPM8	1.09e-03	114	74	4	IPR005821
Domain	Ion_trans	TRPV1 TRPC7 KCNQ4 TRPM8	1.09e-03	114	74	4	PF00520
Domain	Inhibin_asu	BMP8B BMP8A	1.17e-03	13	74	2	IPR002405
Domain	-	ARFGEF2 ARFGEF1	1.57e-03	15	74	2	1.10.1000.11
Domain	Sec7	ARFGEF2 ARFGEF1	1.57e-03	15	74	2	PF01369
Domain	Sec7_alpha_orthog	ARFGEF2 ARFGEF1	1.57e-03	15	74	2	IPR023394
Domain	Sec7	ARFGEF2 ARFGEF1	1.79e-03	16	74	2	SM00222
Domain	SEC7	ARFGEF2 ARFGEF1	1.79e-03	16	74	2	PS50190
Domain	Sec7_dom	ARFGEF2 ARFGEF1	1.79e-03	16	74	2	IPR000904
Domain	Propept_inh	PCSK2 CPA1	2.03e-03	17	74	2	IPR009020
Domain	ARM-type_fold	CLTCL1 ARFGEF2 ARFGEF1 APOB CTNND2 PUM1	2.25e-03	339	74	6	IPR016024
Domain	TGFb_propeptide	BMP8B BMP8A	5.48e-03	28	74	2	PF00688
Domain	TGF-b_N	BMP8B BMP8A	5.48e-03	28	74	2	IPR001111
Domain	TGF-beta-rel	BMP8B BMP8A	7.11e-03	32	74	2	IPR015615
Domain	Chromodomain-like	MORF4L1 CHD9	7.11e-03	32	74	2	IPR016197
Domain	TGFb_CS	BMP8B BMP8A	7.11e-03	32	74	2	IPR017948
Pubmed	Structure and function of immunoglobulins.	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6	1.90e-10	15	82	5	20176268
Pubmed	Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes.	IGLC1 IGLC2 IGLC3 IGLC6	1.99e-09	8	82	4	3122211
Pubmed	Structure and expression of the human immunoglobulin lambda genes.	IGLC7 IGLC1 IGLC2 IGLC3	3.58e-09	9	82	4	2115572
Pubmed	Clustered arrangement of immunoglobulin lambda constant region genes in man.	IGLC1 IGLC2 IGLC3 IGLC6	3.58e-09	9	82	4	6273747
Pubmed	Unraveling of the polymorphic C lambda 2-C lambda 3 amplification and the Ke+Oz- polymorphism in the human Ig lambda locus.	IGLC1 IGLC2 IGLC3	1.26e-08	3	82	3	12077254
Pubmed	Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms.	IGLC1 IGLC2 IGLC3	1.26e-08	3	82	3	2515285
Pubmed	The three-dimensional structure of the fab' fragment of a human myeloma immunoglobulin at 2.0-angstrom resolution.	IGLC1 IGLC2 IGLC3	5.04e-08	4	82	3	4215080
Pubmed	Immunoglobulin lambda-chains. The complete amino acid sequence of a Bence-Jones protein.	IGLC1 IGLC2 IGLC3	5.04e-08	4	82	3	4883841
Pubmed	Comparative studies on the structure of the light chains of human immunoglobulins. IV. Assignment of a subsubgroup.	IGLC1 IGLC2 IGLC3	5.04e-08	4	82	3	6404900
Pubmed	Primary structure of the Mcg lambda chain.	IGLC1 IGLC2 IGLC3	5.04e-08	4	82	3	4415202
Pubmed	[Structural rule of antibodies. Primary structure of a monoclonal immunoglobulin-L-chain of the lambda type, subgroup IV (Bence-Jones-protein Kern). V. The complete amino acid sequence and its genetic interpretation].	IGLC1 IGLC2 IGLC3	5.04e-08	4	82	3	5549568
Pubmed	Physicochemical and functional characterization of the C1r subunit of the first complement component.	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6	9.14e-08	47	82	5	814163
Pubmed	Recognition of immunoglobulins by Fcgamma receptors.	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6	1.02e-07	48	82	5	11955599
Pubmed	Amino acid sequence of the (lambda) light chain of a human myeloma immunoglobulin (IgG New).	IGLC1 IGLC2 IGLC3	1.26e-07	5	82	3	4814727
Pubmed	The amino acid sequence of a lambda type Bence-Jones protein. 3. The complete amino acid sequence and the location of the disulfide bridges.	IGLC1 IGLC2 IGLC3	1.26e-07	5	82	3	4909564
Pubmed	Characterization of the two unique human anti-flavin monoclonal immunoglobulins.	IGLC1 IGLC2 IGLC3	7.01e-07	8	82	3	7737190
Pubmed	Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.	BIVM IGLC1 IGLC2 IGLC3 IGLC6	3.33e-06	96	82	5	23580065
Pubmed	Ron tyrosine kinase receptor synergises with EGFR to confer adverse features in head and neck squamous cell carcinoma.	MST1R EGFR	5.49e-06	2	82	2	23799848
Pubmed	TRPM8 as the rapid testosterone signaling receptor: Implications in the regulation of dimorphic sexual and social behaviors.	TRPV1 TRPM8	5.49e-06	2	82	2	32609392
Pubmed	Amplified cold transduction in native nociceptors by M-channel inhibition.	TRPV1 TRPM8	5.49e-06	2	82	2	24133266
Pubmed	Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells.	HOXA7 EGFR	5.49e-06	2	82	2	20540809
Pubmed	Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.	BMP8B BMP8A	5.49e-06	2	82	2	9463357
Pubmed	The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	5.49e-06	2	82	2	8682296
Pubmed	Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.	ARFGEF2 ARFGEF1	5.49e-06	2	82	2	23918382
Pubmed	Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.	ARFGEF2 ARFGEF1	5.49e-06	2	82	2	17360629
Pubmed	Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.	ARFGEF2 ARFGEF1	5.49e-06	2	82	2	10716990
Pubmed	The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.	BMP8B BMP8A	5.49e-06	2	82	2	21277400
Pubmed	Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains.	ARFGEF2 ARFGEF1	5.49e-06	2	82	2	18203920
Pubmed	Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.	ARFGEF2 ARFGEF1	5.49e-06	2	82	2	18417613
Pubmed	Functional interactions between transient receptor potential M8 and transient receptor potential V1 in the trigeminal system: Relevance to migraine pathophysiology.	TRPV1 TRPM8	5.49e-06	2	82	2	28554243
Pubmed	Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor.	MST1R EGFR	5.49e-06	2	82	2	14499632
Pubmed	Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.	BMP8B BMP8A	5.49e-06	2	82	2	31940275
Pubmed	Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels.	TRPV1 TRPM8	5.49e-06	2	82	2	19482068
Pubmed	The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels.	TRPV1 TRPM8	5.49e-06	2	82	2	15306801
Pubmed	The elevation of apoB in hypercholesterolemic patients is primarily attributed to the relative increase of apoB/Lp-PLA₂.	PLA2G7 APOB	5.49e-06	2	82	2	24092915
Pubmed	Transient receptor potential vanilloid 1 promotes EGFR ubiquitination and modulates EGFR/MAPK signalling in pancreatic cancer cells.	TRPV1 EGFR	5.49e-06	2	82	2	31907951
Pubmed	Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8.	TRPV1 TRPM8	5.49e-06	2	82	2	26645885
Pubmed	Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain.	TRPV1 TRPM8	5.49e-06	2	82	2	33158961
Pubmed	Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition.	TRPV1 TRPM8	5.49e-06	2	82	2	24005250
Pubmed	Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.	ARFGEF2 ARFGEF1	5.49e-06	2	82	2	10212200
Pubmed	EGFR transactivates RON to drive oncogenic crosstalk.	MST1R EGFR	5.49e-06	2	82	2	34821550
Pubmed	Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.	ARFGEF2 ARFGEF1	1.64e-05	3	82	2	19332778
Pubmed	Specific functions of BIG1 and BIG2 in endomembrane organization.	ARFGEF2 ARFGEF1	1.64e-05	3	82	2	20360857
Pubmed	Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura.	TRPV1 TRPM8	1.64e-05	3	82	2	22971321
Pubmed	Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	1.64e-05	3	82	2	9076678
Pubmed	AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.	ARFGEF2 ARFGEF1	1.64e-05	3	82	2	16866877
Pubmed	TRPV1, TRPA1, and TRPM8 are expressed in axon terminals in the cornea: TRPV1 axons contain CGRP and secretogranin II; TRPA1 axons contain secretogranin 3.	TRPV1 TRPM8	1.64e-05	3	82	2	32863706
Pubmed	Relationship between Plasma Lipoprotein-Associated Phospholipase A2 Concentrations and Apolipoprotein in Stable Coronary Artery Disease Patients.	PLA2G7 APOB	1.64e-05	3	82	2	33029257
Pubmed	ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.	TRPV1 TRPM8	1.64e-05	3	82	2	12654248
Pubmed	Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis.	TRPV1 EGFR	1.64e-05	3	82	2	19155296
Pubmed	δ-Catenin Increases the Stability of EGFR by Decreasing c-Cbl Interaction and Enhances EGFR/Erk1/2 Signaling in Prostate Cancer.	EGFR CTNND2	1.64e-05	3	82	2	29629558
Pubmed	Molecular Sensors of Temperature, Pressure, and Pain with Special Focus on TRPV1, TRPM8, and PIEZO2 Ion Channels.	TRPV1 TRPM8	1.64e-05	3	82	2	34825354
Pubmed	Requirement of Bmp8b for the generation of primordial germ cells in the mouse.	BMP8B BMP8A	1.64e-05	3	82	2	10894154
Pubmed	Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis.	ARFGEF2 ARFGEF1	1.64e-05	3	82	2	31199673
Pubmed	BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.	BMP8B BMP8A	1.64e-05	3	82	2	22579288
Pubmed	Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis.	BMP8B BMP8A	1.64e-05	3	82	2	11784057
Pubmed	Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals.	ARFGEF2 ARFGEF1	1.64e-05	3	82	2	27162341
Pubmed	The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).	ARFGEF2 ARFGEF1	1.64e-05	3	82	2	23386609
Pubmed	Rhinovirus upregulates transient receptor potential channels in a human neuronal cell line: implications for respiratory virus-induced cough reflex sensitivity.	TRPV1 TRPM8	1.64e-05	3	82	2	24002057
Pubmed	Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine.	TRPV1 TRPM8	1.64e-05	3	82	2	23508958
Pubmed	Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.	BMP8B BMP8A	1.64e-05	3	82	2	25451979
Pubmed	Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain.	TRPV1 TRPM8	1.64e-05	3	82	2	19482060
Pubmed	Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).	BMP8B BMP8A	1.64e-05	3	82	2	12925636
Pubmed	Three-dimensional structure of a human Fab with high affinity for tetanus toxoid.	IGLC1 IGLC3	1.64e-05	3	82	2	9530559
Pubmed	Human odontoblasts express functional thermo-sensitive TRP channels: implications for dentin sensitivity.	TRPV1 TRPM8	1.64e-05	3	82	2	21168271
Pubmed	Definition of two agonist types at the mammalian cold-activated channel TRPM8.	TRPV1 TRPM8	1.64e-05	3	82	2	27449282
Pubmed	A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.	ARFGEF2 ARFGEF1	1.64e-05	3	82	2	18832381
Pubmed	Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1.	TRPV1 TRPM8	1.64e-05	3	82	2	29117570
Pubmed	Calcium regulation by temperature-sensitive transient receptor potential channels in human uveal melanoma cells.	TRPV1 TRPM8	1.64e-05	3	82	2	24084605
Pubmed	TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective.	TRPV1 TRPM8	1.64e-05	3	82	2	24871046
Pubmed	Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively.	ARFGEF2 ARFGEF1	1.64e-05	3	82	2	18003980
Pubmed	Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor.	EGFR SCAMP3	1.64e-05	3	82	2	9658162
Pubmed	Downregulation of TRPM7, TRPM8, and TRPV1 channels modulate apoptotic parameters and neurodegenerative markers: Focus on neuronal differentiation and Parkinson's disease model.	TRPV1 TRPM8	1.64e-05	3	82	2	37208975
Pubmed	The cellular code for mammalian thermosensation.	TRPV1 TRPM8	1.64e-05	3	82	2	23536068
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPV1 TRPC7 TRPM8	2.47e-05	24	82	3	33884443
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPV1 TRPC7 TRPM8	2.80e-05	25	82	3	16382100
Pubmed	Mouse Thermoregulation: Introducing the Concept of the Thermoneutral Point.	TRPV1 TRPM8	3.28e-05	4	82	2	32294435
Pubmed	Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.	ARFGEF2 ARFGEF1	3.28e-05	4	82	2	11013081
Pubmed	Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling.	TRPV1 TRPM8	3.28e-05	4	82	2	22850668
Pubmed	Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.	ARFGEF2 ARFGEF1	3.28e-05	4	82	2	12606707
Pubmed	The coding of cutaneous temperature in the spinal cord.	TRPV1 TRPM8	3.28e-05	4	82	2	27455110
Pubmed	Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse.	TRPV1 TRPM8	3.28e-05	4	82	2	23410158
Pubmed	Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).	ARFGEF2 ARFGEF1	3.28e-05	4	82	2	12571360
Pubmed	Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing.	ARFGEF2 ARFGEF1	3.28e-05	4	82	2	22084092
Pubmed	Transcriptional landscape of TRPV1, TRPA1, TRPV4, and TRPM8 channels throughout human tissues.	TRPV1 TRPM8	3.28e-05	4	82	2	36126722
Pubmed	A TRP channel that senses cold stimuli and menthol.	TRPV1 TRPM8	3.28e-05	4	82	2	11893340
Pubmed	Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells.	BMP8B BMP8A	3.28e-05	4	82	2	9434160
Pubmed	Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development.	BMP8B BMP8A	3.28e-05	4	82	2	8843393
Pubmed	Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRα3.	TRPV1 TRPM8	3.28e-05	4	82	2	36898840
Pubmed	A histamine-independent itch pathway is required for allergic ocular itch.	TRPV1 TRPM8	3.28e-05	4	82	2	26521042
Pubmed	Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy.	TRPV1 TRPM8	3.28e-05	4	82	2	17521436
Pubmed	TRPA1 is essential for the vascular response to environmental cold exposure.	TRPV1 TRPM8	3.28e-05	4	82	2	25501034
Pubmed	Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus.	TRPV1 TRPM8	3.28e-05	4	82	2	24812665
Pubmed	An introduction to TRP channels.	TRPV1 TRPC7 TRPM8	3.55e-05	27	82	3	16460286
Pubmed	Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set.	BMP8B EGFR PDE4DIP KRI1 DCC	3.63e-05	157	82	5	12466305
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	PLA2G7 DMGDH MST1R FRMD4A MFAP4 CLTCL1 ATP8A1 ERAP1 PDE4DIP ZBTB21 REN ANO3	4.96e-05	1293	82	12	15342556
Pubmed	2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3.	TRPV1 TRPM8	5.47e-05	5	82	2	15194687
Pubmed	The Sensory Coding of Warm Perception.	TRPV1 TRPM8	5.47e-05	5	82	2	32208171
Pubmed	Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1.	TRPV1 TRPM8	5.47e-05	5	82	2	18455988
Pubmed	Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis.	TRPV1 EGFR	5.47e-05	5	82	2	25083990
Cytoband	22q11.2	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6	2.61e-06	120	82	5	22q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr22q11	CLTCL1 IGLC7 IGLC1 IGLC2 IGLC3 IGLC6	1.09e-04	419	82	6	chr22q11
GeneFamily	Immunoglobulin lambda locus at 22q11.2	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6	5.07e-06	89	51	5	353
GeneFamily	Transient receptor potential cation channels	TRPV1 TRPC7 TRPM8	6.59e-05	28	51	3	249
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP8B BMP8A	4.22e-04	11	51	2	455
Coexpression	HALLMARK_PROTEIN_SECRETION	EGFR ARFGEF2 ARFGEF1 SCAMP3 DOP1A	1.30e-05	96	82	5	M5910
Coexpression	DESCARTES_ORGANOGENESIS_NEURAL_PROGENITOR_CELLS	HOXA7 CHST15 KCNQ4 DCC	1.84e-05	50	82	4	MM3639
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	BMP8B RBM44 CHST15 KCNQ4 IGLC2 IGLC3	4.79e-07	158	82	6	17a13c5719eb363f2eb8f1d4e171429c6a1ce1e9
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	BMP8B RBM44 CHST15 KCNQ4 IGLC2 IGLC3	4.79e-07	158	82	6	1397078f909338fa5fa3b01748db891e5e3fc9e7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CHST15 IGLC2 IGLC3 BMP8A AMZ2 FAM111B	4.79e-07	158	82	6	6b51e5ee08e23924f5edbaf0a845a9232fb7ff7a
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	BMP8B RBM44 CHST15 KCNQ4 IGLC2 IGLC3	4.79e-07	158	82	6	e5451cfe67e882eb0c1eca287740f8ab75370abc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CHST15 IGLC2 IGLC3 BMP8A AMZ2 FAM111B	4.79e-07	158	82	6	8dd83a2a4c2ec9cdc3a03df8b51ee22bee1c2888
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BMP8B RBM44 CHST15 KCNQ4 IGLC2 IGLC3	4.97e-07	159	82	6	6ecc3cb2daa5887b59836842be414a00cdcdaeec
ToppCell	BAL-Mild-Lymphocyte-B-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BMP8B RBM44 CHST15 KCNQ4 IGLC2 IGLC3	4.97e-07	159	82	6	1827493fb464bbddb2ee23f99472cfbcaf57405b
ToppCell	Mild_COVID-19-B_cell-Plasmablast\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	BMP8B RBM44 CHST15 KCNQ4 IGLC2 IGLC3	5.55e-07	162	82	6	b67f6fb3d7f6093c8ef02398ff8fea4d0fb41a3b
ToppCell	COVID-19-kidney-Plasma\|kidney / Disease (COVID-19 only), tissue and cell type	IGLC7 CHST15 SIDT1 IGLC2 IGLC3 DCC	7.61e-07	171	82	6	a59a054b8e119215f24dc5c80ad5a8094b3500f9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHST15 SIDT1 IGLC2 IGLC3 IGLC6 DCC	9.62e-07	178	82	6	f815bc76f98aaea2d9058173b02b6f36e45283ce
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHST15 SIDT1 IGLC2 IGLC3 IGLC6 DCC	9.62e-07	178	82	6	a0334764e865fea652c54b94bbc3b173f7cbc9fc
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BMP8B IGLC7 IGLC2 IGLC3 IGLC6 DCC	1.06e-06	181	82	6	f7b08f662eb77ee7a777c6525ddc3195046aaf65
ToppCell	COPD-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	IGLC7 CHST15 IGLC2 IGLC3 IGLC6 MEF2A	1.09e-06	182	82	6	19db653fe04c5e2957eea1f4893b1c1fca4ddcbd
ToppCell	cellseq2-Immune-Lymphocytic_B-Lymphocytic_B-Plasma\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BMP8B IGLC7 IGLC1 IGLC2 IGLC3 DCC	1.32e-06	188	82	6	33360f1c30315d9772731c9067834dc059172b79
ToppCell	356C-Lymphocytic-Plasma_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	IGLC7 CHST15 IGLC2 IGLC3 IGLC6 DCC	1.36e-06	189	82	6	0994aba7a44577a8943af237c9c3575502d0584c
ToppCell	356C-Lymphocytic-Plasma_cell-\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	IGLC7 CHST15 IGLC2 IGLC3 IGLC6 DCC	1.36e-06	189	82	6	d1bd3b5ac32459929e556fb3a4fe8e1e15f6e658
ToppCell	control-Lymphocytic-Plasmablast\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	BMP8B IGLC7 HJURP IGLC2 IGLC3 IGLC6	1.36e-06	189	82	6	2e4c2618d06120f83cb4887dd3497b81984a8607
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Naive_B_cells\|bone_marrow / Manually curated celltypes from each tissue	IGLC7 IGLC1 IGLC2 IGLC3 ZNF318 IGLC6	1.41e-06	190	82	6	3d45d5011305f13634013d9eeb98f235517dd54e
ToppCell	cellseq2-Immune-Lymphocytic_B-Lymphocytic_B\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BMP8B IGLC7 IGLC1 IGLC2 IGLC3 DCC	1.45e-06	191	82	6	17746a32f723c078aba1f7e320b0e3f1ab8bf5c6
ToppCell	cellseq2-Immune-Lymphocytic_B\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BMP8B IGLC7 IGLC1 IGLC2 IGLC3 DCC	1.45e-06	191	82	6	c2c450df810f83163987cd0f7ed9b50025cd3de1
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasmablast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BMP8B CHST15 IGLC2 IGLC3 BMP8A DCC	1.63e-06	195	82	6	c6e31038be2463f1601d52c82efa4e9facb8228f
ToppCell	tumor_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	ATP8A1 IGLC7 RPS2 IGLC2 IGLC3 RNF139	1.73e-06	197	82	6	dcce1c3dc5f3e53c368f758eb0fd5afcd86325e7
ToppCell	LA-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	CLTCL1 HJURP IGLC2 IGLC3 CTNND2	2.23e-06	114	82	5	ca69dddbdc02fa5718c56362649cd4b9b54f94ce
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IGLC7 CHST15 IGLC2 IGLC3 IGLC6	9.41e-06	153	82	5	3724dd498b982be693ddff9cea7671863acf3ff8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IGLC7 CHST15 IGLC2 IGLC3 IGLC6	9.41e-06	153	82	5	d810fc5aff28449ce79b4148558b260878a2c696
ToppCell	390C-Lymphocytic-Plasma_cell-\|390C / Donor, Lineage, Cell class and subclass (all cells)	BMP8B IGLC7 IGLC2 IGLC3 IGLC6	1.03e-05	156	82	5	4f92ca30755430db44402afc603d1ecd8bfc3617
ToppCell	390C-Lymphocytic-Plasma_cell\|390C / Donor, Lineage, Cell class and subclass (all cells)	BMP8B IGLC7 IGLC2 IGLC3 IGLC6	1.03e-05	156	82	5	0de2fc695bd5f8d4633c514f71ea941c88137bac
ToppCell	normal_Lung-B_lymphocytes-MALT_B_cells\|normal_Lung / Location, Cell class and cell subclass	IGLC7 IGLC2 IGLC3 IGLC6 IGHV3-73	1.13e-05	159	82	5	fbd0131b66f4267f7b0d6c3ad874ad097b859074
ToppCell	COVID-19-kidney-Plasma\|COVID-19 / Disease (COVID-19 only), tissue and cell type	IGLC7 CHST15 IGLC2 IGLC3 DCC	1.17e-05	160	82	5	f8d9e459976e711e9ad39ea2b6173140c0589d6e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHST15 IGLC2 IGLC3 IGLC6 DCC	1.24e-05	162	82	5	8ed9149ff53b285591354057055d072b203a47c8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHST15 IGLC2 IGLC3 IGLC6 DCC	1.24e-05	162	82	5	7a05b05a33e1309fb5c0a8171db105ae68491815
ToppCell	343B-Lymphocytic-Plasma_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	IGLC7 IGLC2 IGLC3 IGLC6 DCC	1.32e-05	164	82	5	cf62d34ce9dd220fe61748466c84fd70d9ba697c
ToppCell	10x5'-bone_marrow-Lymphocytic_B_plasma-Plasmablasts\|bone_marrow / Manually curated celltypes from each tissue	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6	1.32e-05	164	82	5	67260e9f569f0acaeb0e65f69cde230f91cd3d26
ToppCell	343B-Lymphocytic-Plasma_cell-\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	IGLC7 IGLC2 IGLC3 IGLC6 DCC	1.32e-05	164	82	5	e00549bc8b3a5566f39031f39d7e698b0b107a7f
ToppCell	Sigmoid-Macrophage-Macrophage\|Macrophage / Region, Cell class and subclass	PLA2G7 FRMD4A IGLC7 IGLC2 IGLC3	1.48e-05	168	82	5	bb16e135b6ae0d66615420b61edd6f62f2a3233c
ToppCell	BAL-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	DMGDH BMP8B HJURP IGLC2 IGLC3	1.52e-05	169	82	5	9ab34f602d46ce87283d243b81621e8806504f43
ToppCell	BAL-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	DMGDH BMP8B HJURP IGLC2 IGLC3	1.52e-05	169	82	5	89fbafdb4628ce7a90c50398870e0f8ee90cfd91
ToppCell	BAL-Control-Lymphocyte-B-Plasmablast-Plasmablast-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMGDH BMP8B HJURP IGLC2 IGLC3	1.52e-05	169	82	5	75d367eb35768d3063096e8866cea649dac3b1bd
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Plasma_cells-IgG_plasma_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGLC7 CHST15 IGLC2 IGLC3 DCC	1.52e-05	169	82	5	0c2384f780ec25710ebb35c0b0df8f4afb53c9b1
ToppCell	tumor_Lung-B_lymphocytes-Plasma_cells\|tumor_Lung / Location, Cell class and cell subclass	IGLC7 IGLC2 IGLC3 IGLC6 IGHV3-73	1.52e-05	169	82	5	b36b7632ce55fc7b6b8b66020563d360b3de6fd7
ToppCell	BAL-Control-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMGDH BMP8B HJURP IGLC2 IGLC3	1.57e-05	170	82	5	7dcb6319ba4d7b258dd0a17449d837800ef46ccc
ToppCell	Control-Lymphoid-B_Plasma\|World / Disease state, Lineage and Cell class	IGLC7 IGLC2 IGLC3 IGLC6 IGHV3-73	1.57e-05	170	82	5	fb05f49b7113470995b3c16683c54dc1a660b73a
ToppCell	BAL-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMGDH BMP8B HJURP IGLC2 IGLC3	1.57e-05	170	82	5	7377e59fba4bf97ba893ccf6b5e149b5152407be
ToppCell	BAL-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMGDH BMP8B HJURP IGLC2 IGLC3	1.57e-05	170	82	5	e18211029e9ffad54458fd921f455172aad407c7
ToppCell	Control-B_cell-Plasmablast\|Control / Disease group,lineage and cell class （2021.01.30）	DMGDH BMP8B HJURP IGLC2 IGLC3	1.61e-05	171	82	5	c09afc4b111b2b5acca75177554f6364ee02d37c
ToppCell	Control-Lymphoid-B_Plasma\|Control / Disease state, Lineage and Cell class	IGLC7 IGLC2 IGLC3 IGLC6 IGHV3-73	1.66e-05	172	82	5	61e33836b8cb0f347f3e699eb587a37073b6fa4c
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGLC7 IGLC2 IGLC3 IGLC6 IGHV3-73	1.70e-05	173	82	5	0ca2169a275404118038c0489a48062879488765
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IGLC7 CHST15 IGLC2 IGLC3 IGLC6	1.70e-05	173	82	5	62ba49c1c16760a8c6cde0cc44e068f94386946a
ToppCell	droplet-Spleen-nan-3m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA7 ARHGAP32 THBS4 EGFR CTNND2	1.80e-05	175	82	5	21bc0e59a9509d38751ce6aad2325f341bc70eff
ToppCell	Control-B_cells-Plasma_cells\|Control / group, cell type (main and fine annotations)	CHST15 IGLC1 IGLC2 IGLC3 DCC	1.80e-05	175	82	5	fb23858cfce71509cafbe0d9728e678012ff2962
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HOXA7 FRY ATP8A1 BIVM USP32	1.80e-05	175	82	5	334fad1a147de6c007cec5089c02c35cf3220f1b
ToppCell	3'_v3-bone_marrow-Lymphocytic_B_plasma-Plasma_cells\|bone_marrow / Manually curated celltypes from each tissue	IGLC1 IGLC2 IGLC3 IGLC6 DCC	1.80e-05	175	82	5	51301f3f44d3e88397f367cedd1e2abaa2be4c6f
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGLC7 IGLC2 IGLC3 ZNF318 FAM111B	1.85e-05	176	82	5	ad05dd934f4ac2e656b3455de091f4c8772de6c8
ToppCell	Control-Lymphoid_P-Plasmablast\|Control / Disease group, lineage and cell class	BMP8B IGLC7 IGLC2 IGLC3 BMP8A	1.85e-05	176	82	5	4b4416f342b732d2cc60133838728880326257d8
ToppCell	Control-Lymphoid_P\|Control / Disease group, lineage and cell class	BMP8B IGLC7 IGLC2 IGLC3 BMP8A	1.85e-05	176	82	5	d895a6b295cd649273ff80ad7785a3e0ae4c728a
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	BMP8B IGLC7 IGLC2 IGLC3 BMP8A	1.90e-05	177	82	5	4c434a7b7cc54cf4dac996bbc3f5124d9ef9a9cd
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	BMP8B IGLC7 IGLC2 IGLC3 BMP8A	1.90e-05	177	82	5	d746122bf8d208c3aa4d156e8c12d0a0e555c6e5
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	BMP8B IGLC7 IGLC2 IGLC3 BMP8A	1.90e-05	177	82	5	fc40918825b7e1eb6861df59dfca944778a64b98
ToppCell	Healthy-Plasmablast\|Healthy / disease group, cell group and cell class	BMP8B IGLC7 OR5AU1 IGLC2 IGLC3	1.90e-05	177	82	5	4ff75c609ac9edf7a94bda42eb7124c559e8b6aa
ToppCell	tumor_Lung-B_lymphocytes-MALT_B_cells\|tumor_Lung / Location, Cell class and cell subclass	IGLC7 IGLC2 IGLC3 IGLC6 DCC	1.90e-05	177	82	5	37e03f51925345f5f716ef3abe1d2c4ccf129020
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BMP8B IGLC7 IGLC2 IGLC3 BMP8A	2.01e-05	179	82	5	837ed81f18257f444eaeadc4fac89deedd4e3061
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BMP8B IGLC7 IGLC2 IGLC3 BMP8A	2.01e-05	179	82	5	494febe77c6d4e6a2c6f0928bbf4c84b0301f188
ToppCell	normal_Lung-B_lymphocytes\|normal_Lung / Location, Cell class and cell subclass	IGLC7 SIDT1 IGLC2 IGLC3 IGLC6	2.01e-05	179	82	5	5b89193486100b6754c1c5eca3105ea955805eae
ToppCell	droplet-Spleen-nan-24m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA7 FRMD4A ARHGAP32 EGFR CTNND2	2.01e-05	179	82	5	d50d29f26d5a2cd8c4cd4e1244e1bb8de072d159
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BMP8B IGLC7 IGLC2 IGLC3 BMP8A	2.01e-05	179	82	5	b6ee4f41d8fb5f047b7bdd8489dda0a89fc6d43f
ToppCell	cellseq-Immune-Lymphocytic_B-Lymphocytic_B\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6	2.06e-05	180	82	5	cd04d7bf92986a5b8a0193c9b92ec47da3929bac
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Plasma_cells-IgG_plasma_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGLC7 CHST15 IGLC2 IGLC3 IGLC6	2.06e-05	180	82	5	588461d603dafa74e274a1dea021fd568e7f7875
ToppCell	cellseq-Immune-Lymphocytic_B\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6	2.06e-05	180	82	5	663a800ab70e7ab7d13183417f9c1ed36907aa5e
ToppCell	Leuk-UTI-Lymphocyte-B-B_naive\|Leuk-UTI / Disease, Lineage and Cell Type	IGLC7 IGLC2 IGLC3 IGLC6 VN1R1	2.12e-05	181	82	5	fb0b5a94796b99c64091f9890f7a09c39bbc3f73
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRANK1 CHST15 IGLC2 IGLC3 DCC	2.12e-05	181	82	5	6cdee2f56bc633b387b4dbbd78c624edbd712c24
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TRANK1 CHST15 IGLC2 IGLC3 DCC	2.12e-05	181	82	5	b75b8b025257bccfe661fd0f92ab284b2a9c12ee
ToppCell	cellseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6	2.23e-05	183	82	5	5ab4aa0304b832f98fff89b6c24ad5b7dd014c11
ToppCell	3'_v3-blood-Lymphocytic_B_plasma\|blood / Manually curated celltypes from each tissue	HJURP IGLC1 IGLC2 IGLC3 BMP8A	2.23e-05	183	82	5	2477183a290b2c45b6fa091ed76969a3826fe3d9
ToppCell	COVID-19-B_cells-Plasma_cells\|COVID-19 / group, cell type (main and fine annotations)	CHST15 IGLC1 IGLC2 IGLC3 DCC	2.23e-05	183	82	5	130c109f63a5e3c8f83cb96e32f4addf513b6415
ToppCell	COVID-19-B_cells\|COVID-19 / group, cell type (main and fine annotations)	CHST15 IGLC1 IGLC2 IGLC3 DCC	2.23e-05	183	82	5	2c016bb59f131a0e821853b085289a3583f0a729
ToppCell	367C-Lymphocytic-Plasma_cell-\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	IGLC7 CHST15 IGLC2 IGLC3 IGLC6	2.29e-05	184	82	5	14a5288d861260f63fbe0cbea3569cf643e7597e
ToppCell	367C-Lymphocytic-Plasma_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	IGLC7 CHST15 IGLC2 IGLC3 IGLC6	2.29e-05	184	82	5	fc708a5c8a7b19fab973c72dc4383a7d30f8b59a
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGLC7 IGLC2 IGLC3 IGLC6 DCC	2.35e-05	185	82	5	ff598af88c7f9d7224cc4ed96b1c3463ef76b550
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Plasma_cells\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGLC7 CHST15 IGLC2 IGLC3 IGLC6	2.35e-05	185	82	5	a4792d8df52d80951fb9d022c49821df52100e67
ToppCell	IIF-Lymphocyte-B-B_naive\|IIF / Disease, Lineage and Cell Type	IGLC7 IGLC2 IGLC3 IGLC6 FAM111B	2.35e-05	185	82	5	dec48908addfc71f32f5ce0ce73f2926e476f60b
ToppCell	healthy_donor-Lymphocytic-Plasma_cell-IgA_Plasmablast\|healthy_donor / Disease condition, Lineage, Cell class and subclass	BMP8B IGLC7 IGLC2 IGLC3 BMP8A	2.41e-05	186	82	5	e2c050ba02e1f84f0b7258dc92e7ff6ab349ff67
ToppCell	IPF-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	IGLC2 IGLC3 IGLC6 DCC FAM111B	2.41e-05	186	82	5	f9c21daf905d0bb0e0e769ca4bb069ea4b1ba25b
ToppCell	Control-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	IGLC7 CHST15 IGLC2 IGLC3 IGLC6	2.41e-05	186	82	5	a08a50bff4e629588faa22440d57334b1df0e8df
ToppCell	control-Lymphocytic-Plasmablast\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	BMP8B IGLC7 IGLC2 IGLC3 IGLC6	2.48e-05	187	82	5	94a44b31ce9fe6fb4758769018fb746e93c8f043
ToppCell	Bac-SEP-Lymphocyte-B\|Bac-SEP / Disease, Lineage and Cell Type	IGLC7 RPS2 IGLC2 IGLC3 IGLC6	2.48e-05	187	82	5	027aa7b5be402fc82ae13c346dfb4c0c751a07e9
ToppCell	healthy_donor-Lymphocytic-Plasma_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	BMP8B IGLC7 IGLC2 IGLC3 BMP8A	2.54e-05	188	82	5	bd53b0371154cff680226897b61c9809a239d1b6
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Plasma_cells-IgG_plasma_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGLC7 IGLC2 IGLC3 IGLC6 DCC	2.54e-05	188	82	5	483d7494704e8732a478b0ffee2f877ee824a6cf
ToppCell	COVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CHST15 SIDT1 IGLC2 IGLC3 DCC	2.54e-05	188	82	5	567b08514d9d84cbb40f9b7a679eec304f023428
ToppCell	PBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BMP8B IGLC7 IGLC2 IGLC3 IGLC6	2.60e-05	189	82	5	73ee4cfb1057832f700be59b6917dedde3e89880
ToppCell	PBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BMP8B IGLC7 IGLC2 IGLC3 IGLC6	2.60e-05	189	82	5	a1bda6ed5c52a5d33d229018cb5982cae6305533
ToppCell	PBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	BMP8B IGLC7 IGLC2 IGLC3 IGLC6	2.60e-05	189	82	5	31594cc59eb1c5b01407dfd72b1487ecca8bf5ec
ToppCell	PBMC-Mild-Lymphocyte-B-Plasmablast-Plasmablast-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	BMP8B IGLC7 IGLC2 IGLC3 IGLC6	2.60e-05	189	82	5	c296660061b46e3abae1e7cf29df20274e5a8add
ToppCell	PBMC-Mild-Lymphocyte-B-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BMP8B IGLC7 IGLC2 IGLC3 IGLC6	2.60e-05	189	82	5	f2daf4889ef98bbefe3e44832618ac102a75b4d9
ToppCell	PBMC-Mild-Lymphocyte-B-Plasmablast\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	BMP8B IGLC7 IGLC2 IGLC3 IGLC6	2.60e-05	189	82	5	9de17ade3cc3e9cd1394338bd048fb1ce64ac50f
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGLC7 HJURP IGLC2 IGLC3 IGLC6	2.67e-05	190	82	5	7de42d8572599693618fb920798a2e52a0b5265c
ToppCell	wk_15-18-Hematologic_Lymphocytic-B-pre-B-I_cell\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ATP8A1 IGLC7 IGLC2 IGLC3 IGLC6	2.74e-05	191	82	5	146edd214aac49f9b910bb982e3d77a052c8b316
ToppCell	(5)_Plasma_IgG\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	IGLC7 CHST15 IGLC2 IGLC3 DCC	2.88e-05	193	82	5	a94ebb3bca62970d5d17b0234893918ee6b7b808
ToppCell	COVID_non-vent-Lymphocytic-Plasma_cell-IgM_Plasmablast\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	IGLC7 HJURP IGLC2 IGLC3 IGHV3-73	2.88e-05	193	82	5	7b4b0271e4fbece703876acb053ae236afb7cdba
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGLC7 HJURP IGLC2 IGLC3 IGHV3-73	2.95e-05	194	82	5	6ef4aeb8d8e35e4df58ff2a8256caa2113291de9
ToppCell	10x5'v1-week_14-16-Lymphocytic_B-B_lineage-immature_B_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ATP8A1 PDE4DIP IGLC2 IGLC3 IGLC6	3.02e-05	195	82	5	ecaaa3d071e763c40d05d088fbf9e8ca06f78f47
Computational	Genes upregulated in subsets of cells of a given type within various tumors	IGLC7 IGLC1 IGLC2 IGLC3 IGLC6	3.20e-06	49	51	5	GAVISH_3CA_MALIGNANT_METAPROGRAM_36_IG
Drug	Alsterpaullone; Down 200; 10uM; PC3; HT_HG-U133A	SYNRG ARHGAP32 CHST15 ZNF45 ZNF318 RNF139 B4GALT5	3.46e-06	188	77	7	7078_DN
Drug	citronellyl acetate	TRPV1 TRPM8	1.13e-05	2	77	2	ctd:C040879
Drug	Sandonorm	APOB REN	1.13e-05	2	77	2	CID000636368
Drug	AC1L2WD4	PLA2G7 CEL ACAT1 APOB	1.48e-05	44	77	4	CID000078971
Disease	nephrotic syndrome (biomarker_via_orthology)	PLA2G7 ACAT1 APOB	3.32e-05	24	77	3	DOID:1184 (biomarker_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	ARHGAP32 CHD9 SCAMP3 CTNND2 MEF2A	4.98e-05	152	77	5	DOID:0060041 (implicated_via_orthology)
Disease	Benign neoplasm of esophagus	EGFR DCC	1.00e-04	6	77	2	C0153942
Disease	Carcinoma in situ of esophagus	EGFR DCC	1.00e-04	6	77	2	C0154059
Disease	Esophageal carcinoma	EGFR DCC	1.40e-04	7	77	2	C0152018
Disease	dementia (is_marker_for)	PLA2G7 EGFR	1.86e-04	8	77	2	DOID:1307 (is_marker_for)
Disease	Pancreatitis, Chronic	CEL CPA1	2.39e-04	9	77	2	C0149521
Disease	eosinophilic esophagitis	PCSK2 DCC NAALADL2 ANO3	8.88e-04	163	77	4	EFO_0004232
Disease	caudal middle frontal gyrus volume measurement	FRY FBP2	1.00e-03	18	77	2	EFO_0010290
Disease	type 2 diabetes mellitus (is_implicated_in)	PLA2G7 PCSK2 CEL APOB	1.06e-03	171	77	4	DOID:9352 (is_implicated_in)
Disease	cerebral infarction (is_marker_for)	PLA2G7 APOB	1.12e-03	19	77	2	DOID:3526 (is_marker_for)
Disease	Coronary heart disease	PLA2G7 APOB	1.79e-03	24	77	2	C0010068
Disease	carnosine measurement	FRMD4A COG5	1.79e-03	24	77	2	EFO_0010470
Disease	Behcet Syndrome	ERAP1 APOB	1.79e-03	24	77	2	C0004943
Disease	response to mTOR inhibitor	USP32 DCC	1.94e-03	25	77	2	EFO_0005417
Disease	cerebrospinal fluid biomarker measurement	PLA2G7 IGLC7 ERAP1	2.05e-03	96	77	3	EFO_0006794
Disease	blood rubidium measurement	FRMD4A ARFGEF2	2.10e-03	26	77	2	EFO_0021529
Disease	diabetes mellitus (implicated_via_orthology)	BMP8B BMP8A	2.10e-03	26	77	2	DOID:9351 (implicated_via_orthology)
Disease	unipolar depression, depressive symptom measurement	ARFGEF2 DCC	2.10e-03	26	77	2	EFO_0003761, EFO_0007006
Disease	obesity (implicated_via_orthology)	BMP8B ACAT1 BMP8A PUM1	2.45e-03	215	77	4	DOID:9970 (implicated_via_orthology)
Disease	cytotoxicity measurement, response to clozapine	IGLC7 CHST15	2.61e-03	29	77	2	EFO_0006952, GO_0097338

Protein segments in the cluster

Peptide	Gene	Start	Entry
KYSYTSTSDDNLLKN	KCTD13	181	Q8WZ19
AAGSLTKFSNRYYSN	CFAP61	976	Q8NHU2
TSKNANASLVYSFLY	AP1M2	71	Q9Y6Q5
NYLYLLFSTDKSHSD	CSMD2	836	Q7Z408
TLFASADTAYVLAYS	ARFGEF1	816	Q9Y6D6
AVTALASLYGTKFNY	CPA1	336	P15085
TLFASADTAYVLAYS	ARFGEF2	761	Q9Y6D5
SDYAFLNQATSIYKT	BIVM	71	Q86UB2
YDSSRTLYAFSAIKA	DOP1A	1376	Q5JWR5
LKKTSSSDYSIFDNY	AMZ2	221	Q86W34
ANAKSAKTYAYLFSH	CEL	426	P19835
SAYAKRNSSVNDSDY	B4GALT5	71	O43286
TLLYNTANYSSEFEA	BBS12	601	Q6ZW61
LKSTGNYVDFYSAAR	CTNND2	1191	Q9UQB3
AANSSDYSIAQFKYL	ATP8A1	826	Q9Y2Q0
AQSYAYSKSLSQSTS	ANO3	41	Q9BYT9
SLIYFDSSATYNLDE	HJURP	386	Q8NCD3
AASYGAQSAASSLAY	RBM14	381	Q96PK6
YRYASLAFTKNSDAK	RBM44	866	Q6ZP01
SQSSSIFRDYYSKTF	IQCM	216	A0A1B0GVH7
YDSLKSLSSGYASFD	GUF1	526	Q8N442
YLAKNSATLFSASDY	MORF4L1	336	Q9UBU8
ASAKYKSEDTTSLSY	DCC	891	P43146
TSALSFHDLSKRYYN	KIAA1109	2536	Q2LD37
AKYLYTESSFLSSAA	FAM185A	241	Q8N0U4
VYLAEKDANSDFSSY	KCNQ4	256	P56696
SLNEGYAKYFDAATT	FBP2	211	O00757
YSKYQFSLSSTEKSQ	ERAP1	786	Q9NZ08
SRSKAKYSYFQGDST	PER3	711	P56645
YQKDATFYNRTASSS	KRI1	81	Q8N9T8
YNTDYSLTSADLSAL	MEF2A	336	Q02078
SYTAYGSSDAKSQKT	PAXBP1	356	Q9Y5B6
SSYSAVALDKAYFQT	ARHGAP32	1086	A7KAX9
DRSASATYYFKDQSA	PLA2G7	181	Q13093
AEAKYRSASSASSLF	PUM1	791	Q14671
YEAAYLSKSLSRLFD	COG5	481	Q9UP83
YSVKAQFKTSNSYTA	FRMD4A	861	Q9P2Q2
SYALAVLSNYDANKT	EGFR	116	P00533
FSSKLDNIYSSDKFY	APOB	1766	P04114
SYDANTVASFYTTKL	CHD9	2286	Q3L8U1
QSNNKYAASSYLSLT	IGLC1	61	P0CG04
EFYQKLSSRYAAASL	HS1BP3	76	Q53T59
QSNNKYAASSYLSLT	IGLC2	61	P0DOY2
QSNNKYAASSYLSLT	IGLC3	61	P0DOY3
QSNNKYAASSYLSLT	IGLC6	61	P0CF74
KLSATSVLYYDSSNN	BMP8A	371	Q7Z5Y6
TSGSYSYSIQKSLAF	DMGDH	801	Q9UI17
QSNNKYAASSYLSLT	IGLC7	61	A0M8Q6
FYRFTASSKASAAAS	FRY	1516	Q5TBA9
SIYSALSANDYFSER	FAM111B	106	Q6SJ93
KLSATSVLYYDSSNN	BMP8B	371	P34820
KNYGSYSTQASAAAA	SCAMP3	81	O14828
YVNALFSKYTAGASL	HOXA7	6	P31268
RSKANSYATAYAASV	IGHV3-73	71	A0A0B4J1V6
SYATAYAASVKGRFT	IGHV3-73	76	A0A0B4J1V6
LSQRSLFKFYTYSSA	RNF139	71	Q8WU17
LFKFYTYSSAFLLAA	RNF139	76	Q8WU17
AYLLKTSSNSGFNLY	RSPH4A	216	Q5TD94
IEDLKYAAFGSYSSN	SYNRG	871	Q9UMZ2
YSLLKSLSFLDFCYS	OR5AU1	111	Q8NGC0
TSADYVFQESYSSKK	REN	346	P00797
ENNTAYAKYADFSIS	MFAP4	136	P55083
QDAYAINSYTRSKAA	ACAT1	211	P24752
FLKSYDSSTSASEAY	CCDC136	786	Q96JN2
YEAAKLLYSNVSNFA	CLTCL1	1211	P53675
DYLYFASSNKSADDF	CHST15	401	Q7LFX5
GLYSSTDNSKYFEFT	THBS4	76	P35443
YIYSSSLFVEKSSLA	ZBTB21	86	Q9ULJ3
SSYNSLYSTCLELFK	TRPV1	626	Q8NER1
DINASAYSAYASFAV	SIDT1	596	Q9NXL6
YFFLLFYSTDSSDLN	VN1R1	16	Q9GZP7
KLSTFSAYLEDHSYN	TTLL6	286	Q8N841
ASSDSFYNKKSYSIS	TOPAZ1	756	Q8N9V7
ISALSDASSAVYYSA	SOX18	366	P35713
NAISYALYKAFSTSE	TRPM8	406	Q7Z2W7
ISKLSYSASQFYLEA	TRANK1	1856	O15050
FAKATFDAISKTYSY	RPS2	236	P15880
YFYVASSLDAAVAAS	MST1R	196	Q04912
ATANAKDLYDIFYSS	ZNF318	1561	Q5VUA4
RAKSYTNDASYRSFS	ZNF45	216	Q02386
AKYIFSLFSSESGNY	USP32	96	Q8NFA0
AYKGLASAAYLSLSS	TRPC7	221	Q9HCX4
ARKDSSQDLLYSYAA	NAALADL2	251	Q58DX5
ATLLSNDLEADSSYY	PDE4DIP	1766	Q5VU43
DLASNYNAEASYDFS	PCSK2	176	P16519