Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mannosyl-oligosaccharide mannosidase activity	MAN2A2 MAN2A1 MAN1C1	1.85e-05	10	109	3	GO:0015924
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	ENGASE MAN2A2 MAN2A1 MAN1C1 LCT FUCA1	2.14e-05	103	109	6	GO:0004553
GeneOntologyMolecularFunction	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	MAN2A2 MAN2A1	2.95e-05	2	109	2	GO:0004572
GeneOntologyMolecularFunction	20-hydroxy-leukotriene B4 omega oxidase activity	CYP4F2 CYP4F3	2.95e-05	2	109	2	GO:0097258
GeneOntologyMolecularFunction	20-aldehyde-leukotriene B4 20-monooxygenase activity	CYP4F2 CYP4F3	2.95e-05	2	109	2	GO:0097259
GeneOntologyMolecularFunction	alpha-mannosidase activity	MAN2A2 MAN2A1 MAN1C1	6.86e-05	15	109	3	GO:0004559
GeneOntologyMolecularFunction	mannosidase activity	MAN2A2 MAN2A1 MAN1C1	8.41e-05	16	109	3	GO:0015923
GeneOntologyMolecularFunction	U5 snRNA binding	PRPF8 EFTUD2	8.83e-05	3	109	2	GO:0030623
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	ENGASE MAN2A2 MAN2A1 MAN1C1 LCT FUCA1	1.39e-04	144	109	6	GO:0016798
GeneOntologyMolecularFunction	alpha-tocopherol omega-hydroxylase activity	CYP4F2 CYP4F3	2.92e-04	5	109	2	GO:0052871
GeneOntologyMolecularFunction	histone H3K27me2/H3K27me3 demethylase activity	KDM7A KDM6A	2.92e-04	5	109	2	GO:0071558
GeneOntologyMolecularFunction	iron ion binding	PLOD3 CYP4F2 HEPH CYP4F22 CYP4F3 KDM7A	3.01e-04	166	109	6	GO:0005506
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4F2 CYP4F3	6.09e-04	7	109	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4F2 CYP4F3	6.09e-04	7	109	2	GO:0018685
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	PLOD3 CYP4F2 CYP4F22 CYP4F3 KDM7A KDM6A	6.88e-04	194	109	6	GO:0016705
GeneOntologyMolecularFunction	transition metal ion binding	TRIM46 PAPPA2 CAD PLOD3 MMP21 CYP4F2 SIRT4 ZRANB3 HEPH ZFPM2 CYP4F22 CYP4F3 KDM7A PLSCR3 TRIM44 VAT1	7.15e-04	1189	109	16	GO:0046914
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4F2 CYP4F3	1.29e-03	10	109	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4F2 CYP4F3	1.29e-03	10	109	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4F2 CYP4F3	1.29e-03	10	109	2	GO:0102033
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4F2 CYP4F3	2.21e-03	13	109	2	GO:0016713
GeneOntologyBiologicalProcess	protein deglycosylation	ENGASE MAN2A2 MAN2A1 MAN1C1	1.98e-06	18	107	4	GO:0006517
GeneOntologyBiologicalProcess	mannose metabolic process	MAN2A2 MAN2A1 MAN1C1	2.89e-05	12	107	3	GO:0006013
Domain	WASPfam_EVH1	WASL WAS	3.44e-05	2	110	2	IPR033927
Domain	-	MAN2A2 MAN2A1 FUCA1	6.90e-05	14	110	3	2.60.40.1180
Domain	Glyco_hydro_b	MAN2A2 MAN2A1 FUCA1	8.59e-05	15	110	3	IPR013780
Domain	Glyco_hydro_38_C	MAN2A2 MAN2A1	3.40e-04	5	110	2	IPR011682
Domain	Alpha-mann_mid	MAN2A2 MAN2A1	3.40e-04	5	110	2	PF09261
Domain	Glyco_hydro_57/38_cen	MAN2A2 MAN2A1	3.40e-04	5	110	2	IPR028995
Domain	Glyco_hydro_38	MAN2A2 MAN2A1	3.40e-04	5	110	2	PF01074
Domain	-	MAN2A2 MAN2A1	3.40e-04	5	110	2	1.20.1270.50
Domain	-	MAN2A2 MAN2A1	3.40e-04	5	110	2	3.20.110.10
Domain	Alpha-mann_mid	MAN2A2 MAN2A1	3.40e-04	5	110	2	SM00872
Domain	Glyco_hydro_38_N	MAN2A2 MAN2A1	3.40e-04	5	110	2	IPR000602
Domain	Glyco_hydro_38/57_N	MAN2A2 MAN2A1	3.40e-04	5	110	2	IPR027291
Domain	Glyco_hydro_38_cen	MAN2A2 MAN2A1	3.40e-04	5	110	2	IPR015341
Domain	Glyco_hydro_38C	MAN2A2 MAN2A1	3.40e-04	5	110	2	PF07748
Domain	WASP_C	WASL WAS	7.08e-04	7	110	2	IPR011026
Domain	Glyco_hydro/deAcase_b/a-brl	MAN2A2 MAN2A1	7.08e-04	7	110	2	IPR011330
Domain	FN3	TRIM46 PAPPA2 IL12RB1 PTPRC IGSF9B MDGA1	7.96e-04	185	110	6	SM00060
Domain	FN3_dom	TRIM46 PAPPA2 IL12RB1 PTPRC IGSF9B MDGA1	1.49e-03	209	110	6	IPR003961
Domain	WH1	WASL WAS	1.83e-03	11	110	2	SM00461
Domain	WH1/EVH1_dom	WASL WAS	1.83e-03	11	110	2	IPR000697
Domain	WH1	WASL WAS	1.83e-03	11	110	2	PF00568
Domain	-	WASL WAS	2.18e-03	12	110	2	3.90.810.10
Domain	Cyt_P450_E_grp-I	CYP4F2 CYP4F22 CYP4F3	2.36e-03	45	110	3	IPR002401
Domain	WH1	WASL WAS	2.57e-03	13	110	2	PS50229
Domain	WH2	WASL WAS	2.99e-03	14	110	2	SM00246
Domain	Cyt_P450_CS	CYP4F2 CYP4F22 CYP4F3	3.76e-03	53	110	3	IPR017972
Domain	WH2	WASL WAS	3.91e-03	16	110	2	PF02205
Domain	PBD	WASL WAS	3.91e-03	16	110	2	SM00285
Domain	Gal_mutarotase_SF_dom	MAN2A2 MAN2A1	4.41e-03	17	110	2	IPR011013
Domain	PBD	WASL WAS	4.41e-03	17	110	2	PF00786
Domain	CYTOCHROME_P450	CYP4F2 CYP4F22 CYP4F3	4.62e-03	57	110	3	PS00086
Domain	-	CYP4F2 CYP4F22 CYP4F3	4.85e-03	58	110	3	1.10.630.10
Domain	p450	CYP4F2 CYP4F22 CYP4F3	4.85e-03	58	110	3	PF00067
Domain	Cyt_P450	CYP4F2 CYP4F22 CYP4F3	5.33e-03	60	110	3	IPR001128
Pathway	REACTOME_REACTIONS_SPECIFIC_TO_THE_COMPLEX_N_GLYCAN_SYNTHESIS_PATHWAY	MAN2A2 MAN2A1 FUCA1	2.92e-05	10	90	3	M27955
Pathway	REACTOME_EICOSANOIDS	CYP4F2 CYP4F22 CYP4F3	5.31e-05	12	90	3	M27129
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F2 CYP4F22 CYP4F3	5.31e-05	12	90	3	M27128
Pathway	REACTOME_EICOSANOIDS	CYP4F2 CYP4F22 CYP4F3	5.31e-05	12	90	3	MM14845
Pathway	REACTOME_REACTIONS_SPECIFIC_TO_THE_COMPLEX_N_GLYCAN_SYNTHESIS_PATHWAY	MAN2A2 MAN2A1 FUCA1	6.87e-05	13	90	3	MM15701
Pathway	REACTOME_FATTY_ACIDS	CYP4F2 CYP4F22 CYP4F3	1.08e-04	15	90	3	M27126
Pathway	KEGG_MEDICUS_REFERENCE_N_GLYCAN_BIOSYNTHESIS	MAN2A2 MAN2A1 MAN1C1	1.33e-04	16	90	3	M47632
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F2 CYP4F22 CYP4F3	1.92e-04	18	90	3	MM14843
Pathway	REACTOME_FATTY_ACIDS	CYP4F2 CYP4F22 CYP4F3	1.92e-04	18	90	3	MM14841
Pathway	WP_BARDETBIEDL_SYNDROME	DYNC2I2 PCARE PKHD1 IFT80 SUFU	2.45e-04	88	90	5	M45557
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F2 CYP4F22 CYP4F3	3.08e-04	21	90	3	M27137
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F2 CYP4F22 CYP4F3	5.23e-04	25	90	3	MM14858
Pathway	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI	MAN2A2 MAN2A1 FUCA1	5.88e-04	26	90	3	M979
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	FLNB CAD GRWD1 PCARE PRPF8 MAST2 EFTUD2 FAM120C	9.71e-07	234	112	8	36243803
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	ROR2 ANKLE2 PTPN14 NDC1 LATS2 N4BP1 PLSCR3 PEAK1	2.32e-06	263	112	8	34702444
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ENGASE PCSK5 COL4A5 HIVEP2 PLOD3 MAN2A2 MAST2 ELAC2 SIL1 HIRA LATS2 KCNQ2 DISP2 SUFU SMURF2	2.73e-06	1105	112	15	35748872
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	COL4A5 FLNB UXS1 PSMF1 HIVEP2 MAN1C1 ROR2 RABGAP1 POMT1 SIL1 PACS1 LATS2 SYNJ2 FAM120C IGSF9B KDM6A SMURF2	5.69e-06	1489	112	17	28611215
Pubmed	Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice.	WASL WAS	1.03e-05	2	112	2	20071778
Pubmed	N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis.	WASL WAS	1.03e-05	2	112	2	20599953
Pubmed	Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.	CYP4F2 CYP4F3	1.03e-05	2	112	2	8026587
Pubmed	Wiskott-Aldrich syndrome: a comprehensive review.	WASL WAS	1.03e-05	2	112	2	23527602
Pubmed	Locus of the gene 'fidget' in the house mouse.	UXS1 FIGN	1.03e-05	2	112	2	14775691
Pubmed	Neuronal Wiskott-Aldrich syndrome protein regulates Pseudomonas aeruginosa-induced lung vascular permeability through the modulation of actin cytoskeletal dynamics.	WASL WAS	1.03e-05	2	112	2	31916311
Pubmed	N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.	WASL WAS	1.03e-05	2	112	2	11584271
Pubmed	Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.	MAN2A2 MAN2A1	1.03e-05	2	112	2	8524845
Pubmed	N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters.	WASL WAS	1.03e-05	2	112	2	38085658
Pubmed	Lunatic fringe protein processing by proprotein convertases may contribute to the short protein half-life in the segmentation clock.	PCSK5 MESP2	1.03e-05	2	112	2	18706457
Pubmed	X-ray scattering study of activated Arp2/3 complex with bound actin-WCA.	WASL WAS	1.03e-05	2	112	2	18462674
Pubmed	Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.	WASL WAS	1.03e-05	2	112	2	17878299
Pubmed	N-Glycan structure analysis using lectins and an alpha-mannosidase activity assay.	MAN2A2 MAN2A1	1.03e-05	2	112	2	17113875
Pubmed	Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.	MAN2A2 MAN2A1	1.03e-05	2	112	2	11778047
Pubmed	Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor structure and function.	IL12RB1 IL23A	1.03e-05	2	112	2	12671732
Pubmed	Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).	WASL WAS	1.03e-05	2	112	2	18650809
Pubmed	Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice.	MAN2A2 MAN2A1	1.03e-05	2	112	2	16754854
Pubmed	Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.	MAN2A2 MAN2A1 MAN1C1	1.44e-05	15	112	3	8892864
Pubmed	Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.	MAN2A2 MAN2A1 MAN1C1	2.14e-05	17	112	3	2355006
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CAD PLOD3 GRWD1 ROR2 NOL11 DZIP1 PRPF8 ANKLE2 ELAC2 EFTUD2 TUBGCP6 PTPN14 NDC1 IFT80 PEAK1 DDHD2	2.28e-05	1487	112	16	33957083
Pubmed	Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages.	WAS CSF1	3.08e-05	3	112	2	19808890
Pubmed	Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α.	WASL WAS	3.08e-05	3	112	2	26463123
Pubmed	N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts.	WASL WAS	3.08e-05	3	112	2	17182853
Pubmed	Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.	CYP4F2 CYP4F3	3.08e-05	3	112	2	15145985
Pubmed	Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells.	KDM7A KDM6A	3.08e-05	3	112	2	32125007
Pubmed	Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.	PTPRC SMURF2	3.08e-05	3	112	2	22552287
Pubmed	Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway.	WASL WAS	3.08e-05	3	112	2	11340081
Pubmed	Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP.	WASL WAS	3.08e-05	3	112	2	9422512
Pubmed	Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function.	WASL WAS	3.08e-05	3	112	2	22411869
Pubmed	Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons.	WASL WAS	3.08e-05	3	112	2	20150425
Pubmed	Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.	WASL IL23A	3.08e-05	3	112	2	29650963
Pubmed	Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia.	IL12RB1 IL23A	3.08e-05	3	112	2	14568135
Pubmed	Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.	WASL WAS	3.08e-05	3	112	2	10724160
Pubmed	Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression.	SOX10 SUFU	3.08e-05	3	112	2	21098272
Pubmed	Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa.	PRPF8 EFTUD2	3.08e-05	3	112	2	17317632
Pubmed	Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP.	WASL WAS	3.08e-05	3	112	2	19741094
Pubmed	The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42.	WAS CSF1	3.08e-05	3	112	2	19561083
Pubmed	Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.	MAN2A2 MAN2A1 MAN1C1	3.56e-05	20	112	3	12560567
Pubmed	Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.	MAN2A2 MAN2A1 MAN1C1	4.79e-05	22	112	3	8673525
Pubmed	Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.	MAN2A2 MAN2A1 MAN1C1	4.79e-05	22	112	3	9109416
Pubmed	Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.	MAN2A2 MAN2A1 MAN1C1	4.79e-05	22	112	3	11530211
Pubmed	Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.	MAN2A2 MAN2A1 MAN1C1	5.49e-05	23	112	3	1736542
Pubmed	Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.	MAN2A2 MAN2A1 MAN1C1	5.49e-05	23	112	3	8093218
Pubmed	Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.	MAN2A2 MAN2A1 MAN1C1	5.49e-05	23	112	3	3099781
Pubmed	Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.	MAN2A2 MAN2A1 MAN1C1	5.49e-05	23	112	3	3264072
Pubmed	Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development.	IL12RB1 IL23A	6.14e-05	4	112	2	15114670
Pubmed	Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.	PCSK5 NGF	6.14e-05	4	112	2	8615794
Pubmed	Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.	IL12RB1 IL23A	6.14e-05	4	112	2	23178247
Pubmed	Neurotrophin secretion: current facts and future prospects.	PCSK5 NGF	6.14e-05	4	112	2	12787574
Pubmed	Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation.	IL12RB1 PTPRC	6.14e-05	4	112	2	17954566
Pubmed	Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.	PRPF8 EFTUD2	6.14e-05	4	112	2	29361316
Pubmed	Variant mapping and mutation discovery in inbred mice using next-generation sequencing.	PCSK5 ABCA12	6.14e-05	4	112	2	26552429
Pubmed	Regulation of virus-induced IL-12 and IL-23 expression in human macrophages.	IL12RB1 IL23A	6.14e-05	4	112	2	12421946
Pubmed	Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly.	WASL WAS	6.14e-05	4	112	2	22921828
Pubmed	Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.	CYP4F2 CYP4F3	6.14e-05	4	112	2	18065749
Pubmed	Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.	WASL WAS	6.14e-05	4	112	2	22585739
Pubmed	Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor β1 via site II and induces p19/interleukin 23 receptor interaction via site III.	IL12RB1 IL23A	6.14e-05	4	112	2	25371211
Pubmed	Potent intestinal Th17 priming through peripheral lipopolysaccharide-based immunization.	IL23A PTPRC	6.14e-05	4	112	2	20130220
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	FLNB UXS1 B3GLCT PLOD3 MAN2A2 MAN2A1 PRPF8 ANKLE2 GFPT1 EFTUD2 PTPN14 NDC1 PTPRC FAM120C DNASE2	6.60e-05	1451	112	15	30550785
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	ROR2 DZIP1 ANKLE2 PACS1 PTPN14 NDC1 PEAK1 VAT1	6.85e-05	421	112	8	36976175
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	MAN2A2 MAN2A1 MAN1C1	7.10e-05	25	112	3	2283726
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	MAN2A2 MAN2A1 MAN1C1	8.01e-05	26	112	3	8218172
Pubmed	Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation.	MEF2C DYRK1B	1.02e-04	5	112	2	15546868
Pubmed	Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP.	WASL WAS	1.02e-04	5	112	2	15169891
Pubmed	Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization.	WASL WAS	1.02e-04	5	112	2	10563804
Pubmed	The acidic regions of WASp and N-WASP can synergize with CDC42Hs and Rac1 to induce filopodia and lamellipodia.	WASL WAS	1.02e-04	5	112	2	11943145
Pubmed	N-wasp is essential for the negative regulation of B cell receptor signaling.	WASL WAS	1.02e-04	5	112	2	24223520
Pubmed	A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.	WASL WAS	1.02e-04	5	112	2	12872157
Pubmed	NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.	PKHD1 SMURF2	1.02e-04	5	112	2	28798345
Pubmed	Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.	WASL WAS	1.02e-04	5	112	2	16293614
Pubmed	Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.	CYP4F2 CYP4F3	1.02e-04	5	112	2	18577768
Pubmed	Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology.	WASL WAS	1.02e-04	5	112	2	27143109
Pubmed	Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.	WASL WAS	1.02e-04	5	112	2	11052943
Pubmed	The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein.	PRPF8 EFTUD2	1.02e-04	5	112	2	9774689
Pubmed	FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro.	WASL WAS	1.02e-04	5	112	2	23437151
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	ZHX3 GRWD1 NOL11 PRPF8 ELAC2 EFTUD2 N4BP1	1.19e-04	339	112	7	30415952
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	COL4A5 UXS1 B3GLCT PLOD3 MAN2A2 MAN2A1 ROR2 RABGAP1 POMT1 ELAC2 SIL1 NDC1 DNASE2	1.34e-04	1201	112	13	35696571
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	WASL CAD WAS PRPF8 EFTUD2	1.46e-04	154	112	5	16055720
Pubmed	An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins.	WASL WAS	1.53e-04	6	112	2	16246732
Pubmed	Lack of association between polymorphisms in interleukin (IL)-12, IL-12R, IL-23, IL-23R genes and Takayasu arteritis in a Chinese population.	IL12RB1 IL23A	1.53e-04	6	112	2	26987707
Pubmed	IL-23 promotes tumour incidence and growth.	IL12RB1 IL23A	1.53e-04	6	112	2	16688182
Pubmed	The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions.	PRPF8 EFTUD2	1.53e-04	6	112	2	10788320
Pubmed	A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.	IL12RB1 IL23A	1.53e-04	6	112	2	17236132
Pubmed	Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion.	WASL WAS	1.53e-04	6	112	2	16582881
Pubmed	The cytochrome P450 4 (CYP4) family.	CYP4F2 CYP4F3	1.53e-04	6	112	2	9068972
Pubmed	Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis.	IL12RB1 IL23A	1.53e-04	6	112	2	24224652
Pubmed	De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation.	WASL WAS	1.53e-04	6	112	2	36622335
Pubmed	YAP Mediates Hair Cell Regeneration in Balance Organs of Chickens, But LATS Kinases Suppress Its Activity in Mice.	SOX10 LATS2	1.53e-04	6	112	2	32341094
Pubmed	The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10.	SOX10 MEF2C	1.53e-04	6	112	2	21610032
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	CAD PLOD3 MAN2A2 PPA1 PRPF8 HEPH SIL1 PTPRC DNASE2	1.70e-04	613	112	9	22268729
Pubmed	Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis.	WASL WAS	2.14e-04	7	112	2	16418535
Pubmed	CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages.	CSF1 PTPRC	2.14e-04	7	112	2	30538245
Pubmed	The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts.	WAS CSF1	2.14e-04	7	112	2	20647543
Pubmed	Down-Regulation of Inpp5e Associated With Abnormal Ciliogenesis During Embryonic Neurodevelopment Under Inositol Deficiency.	PKHD1 IFT80	2.14e-04	7	112	2	34093381
Pubmed	Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer.	WASL WAS	2.14e-04	7	112	2	26506240
Pubmed	A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.	IL12RB1 IL23A	2.14e-04	7	112	2	12023369
GeneFamily	Mannosidases alpha class 2	MAN2A2 MAN2A1	1.42e-04	5	69	2	1194
GeneFamily	Cytochrome P450 family 4	CYP4F2 CYP4F22 CYP4F3	3.47e-04	36	69	3	1003
GeneFamily	Wiskott-Aldrich Syndrome protein family	WASL WAS	1.66e-03	16	69	2	14
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-regulatory_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM46 IL12RB1 PACS1 NDC1 CSF1 IFT80	4.89e-06	172	112	6	10a1d1838492b8ce6dea08844353b51571432c56
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-Regulatory_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM46 IL12RB1 PACS1 NDC1 CSF1 IFT80	4.89e-06	172	112	6	d824e46c8040b0bb9235f9b8a2b35386b303caa0
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 COL4A5 ROR2 ITIH4 ZFPM2 PDLIM3	8.14e-06	188	112	6	3177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 COL4A5 ROR2 ITIH4 ZFPM2 PDLIM3	8.14e-06	188	112	6	293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell	COPD-Epithelial-Mesothelial\|COPD / Disease state, Lineage and Cell class	ROR2 MUC16 FIGN ZFPM2 PDLIM3 NGF	8.39e-06	189	112	6	79bb2593ad5d17f94b17972884241f03a0f43770
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 COL4A5 ROR2 ITIH4 ZFPM2 PDLIM3	8.39e-06	189	112	6	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	facs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 PCSK5 CSDC2 ZFPM2 PDLIM3 FAM131B	8.65e-06	190	112	6	c7bd087f36321cec61b98657433b4d19d135791f
ToppCell	facs-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 PCSK5 CSDC2 ZFPM2 PDLIM3 FAM131B	8.65e-06	190	112	6	834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCell	facs-Tongue-nan-18m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA12 KLK12 POF1B NGF CYP4F22 VAT1	8.91e-06	191	112	6	02f24202f9fdd46c648265a5b3b6f9066aa009fc
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 COL4A5 ROR2 ITIH4 ZFPM2 PDLIM3	8.91e-06	191	112	6	b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-T-T_CD4-T_reg\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TRIM46 IL12RB1 WAS PTPRC IGSF9B MDGA1	1.03e-05	196	112	6	c0028307cf5dddfc4b5db1445fa83b74019a20bd
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PCSK5 COL4A5 LAYN DZIP1 ZFPM2 PDLIM3	1.13e-05	199	112	6	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	PCSK5 COL4A5 LAYN DZIP1 ZFPM2 PDLIM3	1.16e-05	200	112	6	c5e051f1aac8dda376c342a9932785a23450e073
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	PCSK5 COL4A5 LAYN DZIP1 ZFPM2 PDLIM3	1.16e-05	200	112	6	9d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PAPPA2 PCSK5 COL4A5 DZIP1 ZFPM2 PDLIM3	1.16e-05	200	112	6	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PCSK5 COL4A5 LAYN DZIP1 ZFPM2 PDLIM3	1.16e-05	200	112	6	c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell	droplet-Fat-Mat-18m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKLE2 ZRANB3 ZFPM2 YAE1 FAM120C	1.38e-05	121	112	5	e82c9e10b98c8d7ad828cf8ac19a2342014be2ba
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Mup5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PAPPA2 PCSK5 THSD7B FIGN ZFPM2	1.74e-05	127	112	5	6df92f80b8922ca00eb383f79cd8dda4d602adfc
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PAPPA2 PCSK5 B3GLCT THSD7B ZFPM2	2.89e-05	141	112	5	5ef3166c5271aa90fd0633016edfe2c74b835319
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue-Thryoid_normal_tissue\|TCGA-Thryoid / Sample_Type by Project: Shred V9	LAYN DNAH7 ZFPM2 GPR142 CDH16	4.97e-05	158	112	5	8e48952af0831a1fc71ad422e8216b5a92a75991
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal-Thryoid_normal_tissue\|TCGA-Thryoid / Sample_Type by Project: Shred V9	LAYN DNAH7 ZFPM2 GPR142 CDH16	4.97e-05	158	112	5	e5b55c15a8c99c8d7fc94949f0d3c22e0c3fee7b
ToppCell	TCGA-Thryoid-Solid_Tissue_Normal\|TCGA-Thryoid / Sample_Type by Project: Shred V9	LAYN DNAH7 ZFPM2 GPR142 CDH16	4.97e-05	158	112	5	55214d674808584e4d48f8c5e3b8c0e206cb9bb8
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL4A5 ROR2 THSD7B ZFPM2 IGSF9B	5.93e-05	164	112	5	e3983f655cdba308fb192182829f17bef99ce0ba
ToppCell	P15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MARS2 CAD POF1B TUBGCP6 CDH16	6.46e-05	167	112	5	5c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell	(05)_Ciliated-(1)_24hpi\|(05)_Ciliated / shred by cell type and Timepoint	SIRT4 ZFPM2 PDLIM3 MESP2	7.22e-05	88	112	4	76959e7e3f6fae07c9881a29c28ba847be406694
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKLE2 MEF2C ZRANB3 CSF1 DNASE2	7.43e-05	172	112	5	356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKLE2 MEF2C ZRANB3 CSF1 DNASE2	7.43e-05	172	112	5	46fadeee483fdf8402df92ec98575a09c6c15b16
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKLE2 MEF2C ZRANB3 CSF1 DNASE2	7.43e-05	172	112	5	438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Activated_DCs\|Myeloid_cells / Location, Cell class and cell subclass	IL12RB1 HIVEP2 PPA1 GFPT1 DISP2	8.96e-05	179	112	5	5f7e6670a0e906a0a5bc75735408361d88e78fa2
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 FLNB ZRANB3 ZFPM2 PTPN14	8.96e-05	179	112	5	ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCell	primary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Rassf10\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SOX10 IL12RB1 FIGN IL23A	9.73e-05	95	112	4	0ac6cba7e0ed6083f777287f39a871461fa1bca4
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 MMP21 RABGAP1 PTPN14 PDLIM3	9.94e-05	183	112	5	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	IPF-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	ROR2 MUC16 FIGN ZFPM2 NGF	9.94e-05	183	112	5	7df20e3172a1220ff427f30181f4f0c3b7fe2d42
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-plasma_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAN1C1 PPA1 IL23A GFPT1 SIL1	1.05e-04	185	112	5	ff95a45b7cb782961bb8f008b6b507af2d4cb8b7
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PAPPA2 PCSK5 DZIP1 ZFPM2 PDLIM3	1.05e-04	185	112	5	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	MAST2 NDC1 PTPRC IFT80 USPL1	1.05e-04	185	112	5	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 ROR2 ITIH4 ZFPM2 PDLIM3	1.07e-04	186	112	5	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	MAST2 NDC1 PTPRC IFT80 USPL1	1.07e-04	186	112	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 ZHX3 MAN1C1 PKHD1 CYP4F3	1.07e-04	186	112	5	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK5 FLNB RABGAP1 PTPN14 PDLIM3	1.10e-04	187	112	5	7170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A5 FIGN ZFPM2 SYNJ2 IGSF9B	1.13e-04	188	112	5	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A5 ACOT6 ITIH4 PDLIM3 IGSF9B	1.13e-04	188	112	5	61f010c165826b434ca3d27553d4c9e13d2c0c51
ToppCell	droplet-Lung-nan-18m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A5 ACOT6 ITIH4 PDLIM3 IGSF9B	1.13e-04	188	112	5	7553ef7de3575af4cf34704b405b551c1af8eb83
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A5 FIGN ZFPM2 SYNJ2 IGSF9B	1.13e-04	188	112	5	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	SupraBC-Differ-KC\|World / shred by cell class for mouse tongue	ABCA12 KLK12 POF1B NGF CYP4F22	1.16e-04	189	112	5	6412741b88e241304033b41effca0c77a374d907
ToppCell	facs-Tongue-nan-3m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA12 KLK12 POF1B NGF CYP4F22	1.19e-04	190	112	5	719a5cecc3e8001ca9c38165258b5ff9c800713a
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCSK5 ROR2 ITIH4 ZFPM2 PDLIM3	1.22e-04	191	112	5	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 DNAH7 POF1B PTPN14 PKHD1	1.22e-04	191	112	5	5a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 DNAH7 POF1B PTPN14 PKHD1	1.22e-04	191	112	5	55ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THSD7B FIGN ZFPM2 PDLIM3 NGF	1.25e-04	192	112	5	24e2f15f5767a97eb3b389922bcfd7b13805e1ce
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PLEKHA4 CSF1 LATS2 PDLIM3 USPL1	1.25e-04	192	112	5	3f925a80b5e2b0577d573e88598a2984a5f6a789
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UXS1 PLOD3 GRWD1 DYNC2I2 NDC1	1.28e-04	193	112	5	f92bbe70e6c725bfb8c08bfc2a94e375528151a3
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	HIVEP2 PLEKHA4 PTPN14 CSF1 LATS2	1.28e-04	193	112	5	dbf0fe496254320c894568c31e5f9ce63707d1b5
ToppCell	facs-Marrow-KLS-18m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UXS1 PLOD3 GRWD1 DYNC2I2 NDC1	1.28e-04	193	112	5	44ba79db566d0fa3bbcfe3adf9164bf8c3cb0bc3
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAPPA2 PCSK5 ITIH4 PDLIM3 FAM131B	1.31e-04	194	112	5	7bf6edefd13047e04665dbe34051ef3f481f85a4
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAPPA2 PCSK5 ITIH4 PDLIM3 FAM131B	1.31e-04	194	112	5	19e5beae2c1f8bf42cbe618e89810ce7b01a396c
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 PCSK5 THSD7B ITIH4 PDLIM3	1.34e-04	195	112	5	d32716a12014522492becbde1088dc1106308490
ToppCell	facs-Mammary_Gland\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX10 GRWD1 CSDC2 CSF1 PDLIM3	1.34e-04	195	112	5	21cfcb751e548591fc8724a8329c294da6012e0f
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAPPA2 PCSK5 CSDC2 PDLIM3 FAM131B	1.34e-04	195	112	5	c6bb16c0076639c6ddef1a15d8cba44bc29c077d
ToppCell	droplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 PCSK5 THSD7B ITIH4 PDLIM3	1.34e-04	195	112	5	b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAPPA2 PCSK5 CSDC2 PDLIM3 FAM131B	1.34e-04	195	112	5	ea89f80d3d7e9f737442f7c1aa1791d277ffc90c
ToppCell	COVID-19-Epithelial-Club,_Basal_cells\|COVID-19 / Condition, Lineage and Cell class	COL4A5 MUC16 KLK12 POF1B CYP4F3	1.37e-04	196	112	5	dd32046067d93b9484cfbf1d7826a436a3d9f0e9
ToppCell	facs-Marrow-KLS-3m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UXS1 PLOD3 GRWD1 NDC1 DNASE2	1.37e-04	196	112	5	c5adc95df9e1d1884a7988336e459a98c5a6769b
ToppCell	severe-dn_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FLNB LAYN LCT IL23A PACS1	1.37e-04	196	112	5	14baf176bce5750ef50d6838b748caf68c151e05
ToppCell	facs-Marrow-KLS-3m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UXS1 PLOD3 GRWD1 NDC1 DNASE2	1.37e-04	196	112	5	81d1fd63397b2cf893607d828b61a926fa65185f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ROR2 ZFPM2 CSF1 PDLIM3 PEAK1	1.40e-04	197	112	5	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ROR2 ZFPM2 CSF1 PDLIM3 PEAK1	1.40e-04	197	112	5	e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ROR2 ZFPM2 CSF1 PDLIM3 PEAK1	1.40e-04	197	112	5	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	normal_Lymph_Node-Myeloid_cells-CD1c+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	WAS PPA1 MEF2C RNASE6 PTPRC	1.40e-04	197	112	5	2b3cd318c988364adcba4441444045914d58fe46
ToppCell	severe-dn_T\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FLNB LAYN LCT IL23A PACS1	1.44e-04	198	112	5	d4f2213af45ada47e6c62675f468ce05692db507
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ROR2 ZFPM2 CSF1 PDLIM3 PEAK1	1.44e-04	198	112	5	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	background-Hepatic_Stellate_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	PCSK5 ROR2 FIGN ZFPM2 PDLIM3	1.44e-04	198	112	5	bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCell	343B-Fibroblasts-Fibroblast-K_(Pericytes)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	LAYN MEF2C ITIH4 CSDC2 PDLIM3	1.51e-04	200	112	5	4fb6fd703aca9a992924245105ad99163146a415
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	ROR2 MUC16 POF1B PACS1 SYNJ2	1.51e-04	200	112	5	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-dn_T\|Int-URO / Disease, condition lineage and cell class	UXS1 CAD NDC1 IFT80 DDHD2	1.51e-04	200	112	5	020439d9e70fff7246650ab0e9105236688c3ec3
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	PAPPA2 PCSK5 COL4A5 ZFPM2 PDLIM3	1.51e-04	200	112	5	593bf6a7c557437db9a9249a5058a46014179ef6
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PAPPA2 PCSK5 COL4A5 ZFPM2 PDLIM3	1.51e-04	200	112	5	8988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PCSK5 COL4A5 DZIP1 ZFPM2 PDLIM3	1.51e-04	200	112	5	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PCSK5 COL4A5 DZIP1 ZFPM2 PDLIM3	1.51e-04	200	112	5	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCell	343B-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	LAYN MEF2C ITIH4 CSDC2 PDLIM3	1.51e-04	200	112	5	b50de1f8c8f598e281951e4587f2d96c11aac836
Disease	tumor necrosis factor receptor superfamily member EDAR measurement	MEF2C ZFPM2 SUFU	1.08e-05	12	110	3	EFO_0008310
Disease	noggin measurement	HIVEP2 MEF2C SUFU	3.95e-05	18	110	3	EFO_0021995
Disease	interstitial cystitis (is_implicated_in)	CSF1 NGF	4.12e-05	3	110	2	DOID:13949 (is_implicated_in)
Disease	Wiskott-Aldrich syndrome (implicated_via_orthology)	WASL WAS	8.22e-05	4	110	2	DOID:9169 (implicated_via_orthology)
Disease	Short rib-polydactyly syndrome, Verma-Naumoff type	DYNC2I2 IFT80	1.37e-04	5	110	2	C0432197
Disease	low tension glaucoma	FLNB ZFPM2	4.87e-04	9	110	2	EFO_1001022
Disease	aspartate aminotransferase measurement	TRIM46 FLNB CYP4F2 RABGAP1 THSD7B LCT CSF1 PTPRC NGF IFT80 VAT1	5.68e-04	904	110	11	EFO_0004736
Disease	UDP-glucuronic acid decarboxylase 1 measurement	UXS1 ZFPM2	7.41e-04	11	110	2	EFO_0803221
Disease	Jeune thoracic dystrophy	DYNC2I2 IFT80	7.41e-04	11	110	2	C0265275
Disease	Congenital Nonbullous Ichthyosiform Erythroderma	ABCA12 CYP4F22	7.41e-04	11	110	2	C0079154
Disease	Congenital ichthyosis of skin	ABCA12 CYP4F22	7.41e-04	11	110	2	cv:C0020758
Disease	cleft palate (is_implicated_in)	FLNB ROR2	8.87e-04	12	110	2	DOID:674 (is_implicated_in)
Disease	disks large homolog 3 measurement	MEF2C ZFPM2	8.87e-04	12	110	2	EFO_0802472
Disease	dickkopf‐related protein 1 measurement	ZFPM2 SUFU	8.87e-04	12	110	2	EFO_0010620
Disease	Down syndrome (implicated_via_orthology)	SYNJ2 DYRK1B	1.40e-03	15	110	2	DOID:14250 (implicated_via_orthology)
Disease	cochlin measurement	MEF2C ZFPM2	1.60e-03	16	110	2	EFO_0801481
Disease	biological sex	FIGN SIL1 PKHD1 IGSF9B PEAK1	1.74e-03	230	110	5	PATO_0000047
Disease	esophageal carcinoma, gastric carcinoma	ATG2B MAST2	1.81e-03	17	110	2	EFO_0000178, EFO_0002916
Disease	bipolar I disorder	B3GLCT PRSS36 ITIH4 PACS1	1.95e-03	141	110	4	EFO_0009963
Disease	Carcinoma of bladder	PEAK1 KDM6A	2.03e-03	18	110	2	C0699885
Disease	glomerulonephritis (is_marker_for)	CSF1 NGF	2.26e-03	19	110	2	DOID:2921 (is_marker_for)
Disease	intellectual disability (implicated_via_orthology)	HIVEP2 MEF2C DYRK1B	2.80e-03	75	110	3	DOID:1059 (implicated_via_orthology)
Disease	Disproportionate short stature	FLNB ROR2 IFT80	3.02e-03	77	110	3	C0878659
Disease	complement factor H-like 1 protein measurement	SYNJ2 KCNQ2	3.03e-03	22	110	2	EFO_0600092
Disease	tooth agenesis	NOL11 THSD7B	3.03e-03	22	110	2	EFO_0005410

Protein segments in the cluster

Peptide	Gene	Start	Entry
VHPQSEDYWGHVNPI	UXS1	211	Q8NBZ7
FPQWHLGNHAVEPVT	FAM241B	76	Q96D05
QIGGHPWHYIVTPNK	DCAF17	296	Q5H9S7
DVDPHQFPAVHRWKS	ANKLE2	846	Q86XL3
HQVPISFHKHWNIDP	B3GLCT	456	Q6Y288
KIWAPGPHNSPSHNQ	ABCA12	1001	Q86UK0
WSNPLEEHNHQSLVP	ACOT6	296	Q3I5F7
SQRDGTWKPPAVQHH	DISP2	131	A7MBM2
WAGGDVPHKTHQAPA	DYRK1B	516	Q9Y463
GLQQTHPNSFWPGHL	EFCAB12	496	Q6NXP0
QPTWGEFLDHHKEQP	ATG2B	456	Q96BY7
AQGCLQAPKSPWHTH	C9orf152	106	Q5JTZ5
TFKNPLVWVHASPEH	ITIH4	786	Q14624
HETPETPFVGHWNLS	KIAA1107	711	Q9UPP5
PGTHVVSHFVNWETP	NOL11	351	Q9H8H0
KGNVWQQAHVPISPS	MDGA1	871	Q8NFP4
ITGSWNPKSPHFQVV	RABGAP1	381	Q9Y3P9
PHIADSWPQLQDHFS	PLOD3	341	O60568
WEGTHSPVTQRFPHS	MUC16	5886	Q8WXI7
WVETHSIVIQGFPHP	MUC16	7646	Q8WXI7
PEHAQWPEQHFDITS	FIGN	16	Q5HY92
KQGHTLFVPTGWIHA	KDM7A	341	Q6ZMT4
VPAGHTIPQAHWTKL	NGF	26	P01138
LQVFVVPHSHNDPGW	MAN2A1	166	Q16706
VPHSHNDPGWLKTFN	MAN2A1	171	Q16706
QHVAPVTSVEWHPQD	GRWD1	351	Q9BQ67
HVSGWGITNHPRNPF	KLK12	141	Q9UKR0
AWDTLTSPNNKHPEH	LATS2	1021	Q9NRM7
TKKQHTIWPSPHQGN	LAYN	271	Q6UX15
PPQSLLGHDHWIFAQ	MESP2	6	Q0VG99
NPQHEDDHKSPSWIS	ZFPM2	1066	Q8WW38
SHPPVQQQAHSWCLT	KDM6A	456	O15550
QVVWLPEPGHSHRFQ	DYNC2I2	271	Q96EX3
KWGEEHIPGSPFHVT	FLNB	2586	O75369
NPQHVHIYSASWGPD	PCSK5	261	Q92824
PGTTIGHVLQTWHPF	PLSCR3	176	Q9NRY6
TSWQPQSHPRQGHGT	KCNQ2	716	O43526
WPGIPTHNIDAFVHI	MMP21	386	Q8N119
PPVQRHHWFTEAKGE	PEAK1	966	Q9H792
TKHHEGFTNWPSPVS	FUCA1	136	P04066
EFLPVNWHSPLHSTG	DDHD2	266	O94830
HVHQEPSKRIPSWSG	PRKD3	241	O94806
IGGFSQHVNHVWPQT	LCT	706	P09848
SVTGWQQQHLHNMPP	MEF2C	346	Q06413
APTQPRWNTHGHVSN	TUBGCP6	1071	Q96RT7
PQVIHSAHWQQPDSS	POF1B	196	Q8WVV4
WGKTPAVQPQHSHES	FAM131B	91	Q86XD5
LAAQWPTHVKHFPVG	PACS1	941	Q6VY07
NVFGKPVPCWLHSHQ	POMT1	331	Q9Y6A1
FPLQTHGPWISHVTR	PRSS36	541	Q5K4E3
GDSGISSHFQPWPKH	PAPPA2	211	Q9BXP8
QPHEHPITSVAWAPD	IFT80	226	Q9P2H3
VKGHHVSQEPWNSSI	DNASE2	201	O00115
TGQDWNHTPQKTDHP	CSF1	376	P09603
HQTEPVQVASRWHVP	LINC00315	101	P59091
VHSQTIQIPHCPQGW	COL4A5	1576	P29400
KPHWQQAAPSFHLSV	DNAH7	51	Q8WXX0
ITEAFHHQPEWGNPN	FAM120C	541	Q9NX05
QPEGHHWETQQIPSL	IL23A	136	Q9NPF7
LISVFGTHHNPAVWP	CYP4F2	421	P78329
PHVSGLSQEFESHWP	GPR142	131	Q7Z601
PGLNQTWHIPADTHT	IL12RB1	326	P42701
WVFNTEAHPLPVNHS	MAN1C1	606	Q9NR34
LQVFVVPHSHNDPGW	MAN2A2	166	P49641
VPHSHNDPGWIKTFD	MAN2A2	171	P49641
IPPEGCWKAQHLHTQ	MAST2	1611	Q6P0Q8
AIPQTWEDPGHNDKH	PPA1	96	Q15181
WNQGLPSIQHFPHSA	KLF17	51	Q5JT82
PSHSHPFALKENWNL	ARRDC1-AS1	51	Q9H2J1
LISVFGTHHNPAVWP	CYP4F3	421	Q08477
HHTVTIPPVGWTNTA	ENGASE	166	Q8NFI3
QLAPHTPHETWSGQV	CSDC2	136	Q9Y534
PTWVNHNGKPIFSVD	HIRA	6	P54198
IYGTHHNPTVWPDSK	CYP4F22	431	Q6NT55
QDGHVLWGPQPVLVH	CDH16	101	O75309
PIHEQWEKANVSSPH	PSMF1	141	Q92530
KWQNVHFHRSGSPTV	CAMK2D	461	Q13557
KAIAWHHSGPPSGQN	PCARE	956	A6NGG8
HLAEYVHGSQAWTPP	TRIM44	56	Q96DX7
FHPWGTQKAQHEPTL	TRIM46	201	Q7Z4K8
PLFWEQPGLQVGSHH	SYNJ2	256	O15056
WATHGEPSPVNSHPQ	GFPT1	96	Q06210
HWSQEPRTQAHSGSP	PLEKHA4	316	Q9H4M7
HIYNWTIPEGHAPTD	HEPH	161	Q9BQS7
ATQGPLPHTCHDFWQ	PTPN14	981	Q15678
HPTHEWQALQPGQAV	SIL1	71	Q9H173
VGWPQFSSHQPNPAH	SIRT4	111	Q9Y6E7
HLWSPQVSEDGKAHP	PDLIM3	86	Q53GG5
QLSPHSVNVHWGPQG	DIP2C-AS1	181	Q8N8Z3
AHWFEIQHIQPSPLQ	RNASE6	31	Q93091
PQEPWHKVRNDHSIS	PKHD1	3256	P08F94
TKSGHQCQPWALQHP	ROR2	331	Q01974
PHFAHVLNAWGAFNP	DZIP1	821	Q86YF9
WGTHQTVHLPGQLPQ	PRPF8	2151	Q6P2Q9
HTQTGVSTWHDPRVP	SMURF2	271	Q9HAU4
AFCDPEKQHIWHIPG	URGCP	866	Q8TCY9
NVIPEWHPLNAAHFG	USPL1	381	Q5W0Q7
HSEQRRGKHQPWQSP	ELAC2	186	Q9BQ52
HNGSWVHLTINAPPT	IGSF9B	126	Q9UPX0
GPQSHSPTHWEQPVY	SOX10	446	P56693
NVGSPSANIPEHWHY	SUFU	76	Q9UMX1
PSGFKHVSHVGWDPQ	WAS	241	P42768
NSVKPWQQLNHHPGT	TTLL2	136	Q9BWV7
QAITPEPFHHVVLQW	MARS2	231	Q96GW9
WPSHLPIVAHAEQQT	CAD	1581	P27708
HAHSENPSPTWILEQ	YAE1	191	Q9NRH1
QGHIKPHIDSVWPFE	VAT1	351	Q99536
PSNFQHIGHVGWDPN	WASL	206	O00401
LLEQQDPHWHVTGPV	THSD7B	416	Q9C0I4
FHHWQIVPGDPLDKS	EFTUD2	901	Q15029
WQAHFPHPFAQHPQK	HIVEP2	1226	P31629
THPSAKRQSWHQTPD	ZHX3	596	Q9H4I2
HQGVITWNPPQRSFH	PTPRC	406	P08575
VTHIQFTSWPDHGVP	PTPRC	811	P08575
PGEGHFWQVDHIKPV	ZRANB3	1011	Q5FWF4
CHPLFHGSKTTPNVW	nan	56	Q9UFV3
QGAPSSHWLPQQPHF	N4BP1	816	O75113
SLSQPGGHPHNWTAI	NDC1	351	Q9BTX1