Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574 ZNF667

2.88e-1112442514GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574 ZNF667

3.84e-1112712514GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574 ZNF667

2.41e-1014592514GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574

2.44e-0914122513GO:0000981
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

ZNF91 ZNF493 ZNF43 ZNF726 ZNF574

5.68e-04560255GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

ZNF91 ZNF493 ZNF43 ZNF726 ZNF574

5.97e-04566255GO:0001216
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ZNF91 ZNF493 ZNF43 ZNF726

6.28e-04320254GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ZNF91 ZNF493 ZNF43 ZNF726

6.73e-04326254GO:0001217
GeneOntologyMolecularFunctionmolecular adaptor activity

ZNF91 ZNF493 ZNF43 KSR2 CGAS MSL2

5.61e-031356256GO:0060090
GeneOntologyBiologicalProcesstransposable element silencing

ZNF91 ZNF493 ZNF43 ZNF726

2.65e-0746254GO:0010526
GeneOntologyBiologicalProcessretrotransposition

ZNF91 ZNF493 ZNF43 ZNF726

3.15e-0748254GO:0032197
GeneOntologyBiologicalProcesstransposition

ZNF91 ZNF493 ZNF43 ZNF726

3.72e-0750254GO:0032196
GeneOntologyBiologicalProcessnegative regulation of gene expression via chromosomal CpG island methylation

ZNF429 ZNF726

3.51e-0423252GO:0044027
GeneOntologyBiologicalProcesssex determination

ZNF429 ZNF726

6.42e-0431252GO:0007530
MousePhenodecreased eosinophil cell number

ADAMTS16 ZNF91 ZNF493 ZNF43 IL17RB

8.61e-0984135MP:0005012
MousePhenoabnormal myeloblast morphology/development

ADAMTS16 ZNF91 ZNF493 ZNF43 SPEG IL17RB

4.12e-07360136MP:0002414
MousePhenodecreased granulocyte number

ADAMTS16 ZNF91 ZNF493 ZNF43 IL17RB

2.18e-06254135MP:0000334
MousePhenoabnormal eosinophil cell number

ADAMTS16 ZNF91 ZNF493 ZNF43 IL17RB

2.22e-06255135MP:0002602
MousePhenoabnormal eosinophil morphology

ADAMTS16 ZNF91 ZNF493 ZNF43 IL17RB

2.44e-06260135MP:0005061
MousePhenoabnormal bone marrow cell morphology/development

ADAMTS16 ZNF91 ZNF493 ZNF43 SPEG IL17RB

2.05e-05706136MP:0002398
MousePhenoabnormal granulocyte number

ADAMTS16 ZNF91 ZNF493 ZNF43 SPEG IL17RB

4.33e-05805136MP:0020201
MousePhenoabnormal granulocyte morphology

ADAMTS16 ZNF91 ZNF493 ZNF43 SPEG IL17RB

5.32e-05835136MP:0002441
MousePhenomaternal imprinting

ZNF429 ZNF726

2.98e-0428132MP:0003122
MousePhenoabnormal myeloid leukocyte morphology

ADAMTS16 ZNF91 ZNF493 ZNF43 SPEG IL17RB

5.97e-041292136MP:0008250
MousePhenogenetic imprinting

ZNF429 ZNF726

9.92e-0451132MP:0003121
Domainzf-C2H2_6

ZNF429 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF43 ZNF726 ZNF574 ZNF667

1.77e-153142512PF13912
DomainKRAB

ZNF429 ZNF430 ZNF431 ZNF100 ZNF680 ZNF91 ZNF302 ZNF738 ZNF257 ZNF43 ZNF726 ZNF667

8.51e-153582512PS50805
DomainKRAB

ZNF429 ZNF430 ZNF431 ZNF100 ZNF680 ZNF91 ZNF302 ZNF738 ZNF257 ZNF43 ZNF726 ZNF667

8.51e-153582512PF01352
DomainKRAB

ZNF429 ZNF430 ZNF431 ZNF100 ZNF680 ZNF91 ZNF302 ZNF738 ZNF257 ZNF43 ZNF726 ZNF667

1.22e-143692512SM00349
DomainKRAB

ZNF429 ZNF430 ZNF431 ZNF100 ZNF680 ZNF91 ZNF302 ZNF738 ZNF257 ZNF43 ZNF726 ZNF667

1.26e-143702512IPR001909
Domain-

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574 ZNF667

1.90e-1467925143.30.160.60
Domainzf-C2H2

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574 ZNF667

2.52e-146932514PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574 ZNF667

2.57e-146942514IPR013087
DomainZINC_FINGER_C2H2_2

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574 ZNF667

1.17e-137752514PS50157
DomainZINC_FINGER_C2H2_1

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574 ZNF667

1.21e-137772514PS00028
DomainZnf_C2H2-like

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574 ZNF667

1.68e-137962514IPR015880
DomainZnf_C2H2

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574 ZNF667

1.96e-138052514IPR007087
DomainZnF_C2H2

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574 ZNF667

2.06e-138082514SM00355
DomainIon_trans_dom

TRPM8 TRPC7

1.01e-02114252IPR005821
DomainIon_trans

TRPM8 TRPC7

1.01e-02114252PF00520
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF429 ZNF430 ZNF431 ZNF100 ZNF680 ZNF302 ZNF493 ZNF738 ZNF257 ZNF43 ZNF726 ZNF667

9.92e-0813872112M734
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

ZNF429 ZNF91 ZNF493 ZNF43 ZNF726 ZNF667

6.87e-04768216MM14851
PathwayREACTOME_TRP_CHANNELS

TRPM8 TRPC7

7.81e-0428212M27241
PathwayREACTOME_TRP_CHANNELS

TRPM8 TRPC7

7.81e-0428212MM14943
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

ZNF429 ZNF91 ZNF493 ZNF43 ZNF726 ZNF667

3.01e-031022216MM15436
PathwayREACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS

ZNF429 ZNF726

3.10e-0356212MM17236
Pubmed

Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.

ZNF429 ZNF91 ZNF493 ZNF43 ZNF726

3.75e-131525515885501
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF430 ZNF100 ZNF680 ZNF91 ZNF493 ZNF738 ZNF257 ZNF726

4.62e-1318125837372979
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF429 ZNF91 ZNF493 ZNF43 ZNF726

1.47e-112925514563677
Pubmed

Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.

ZNF429 ZNF91 ZNF493 ZNF43 ZNF726

2.34e-10492559630514
Pubmed

The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.

ZNF117 ZNF91 ZNF43

1.83e-0882532023909
Pubmed

Functional analysis of the SRY-KRAB interaction in mouse sex determination.

ZNF91 ZNF493 ZNF43

3.92e-081025318588511
Pubmed

Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.

ZNF91 ZNF493 ZNF43

5.39e-081125315469996
Pubmed

Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.

ZNF91 ZNF493 ZNF43

9.34e-081325319850934
Pubmed

Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.

ZNF100 ZNF91 ZNF43

1.83e-07162538467795
Pubmed

The KRAB zinc finger protein RSL1 modulates sex-biased gene expression in liver and adipose tissue to maintain metabolic homeostasis.

ZNF429 ZNF726

4.95e-06525224190968
Pubmed

A pair of mouse KRAB zinc finger proteins modulates multiple indicators of female reproduction.

ZNF429 ZNF726

4.95e-06525220042539
Pubmed

The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.

ZNF429 ZNF726

7.43e-06625230846446
Pubmed

The human genome contains hundreds of genes coding for finger proteins of the Krüppel type.

ZNF117 ZNF91

7.43e-0662522505992
Pubmed

The KRAB zinc finger protein RSL1 regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration.

ZNF429 ZNF726

1.04e-05725222801370
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

ZNF100 ZNF680 ZNF91 ZNF257 ZNF726

1.54e-0545125536168627
Pubmed

Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes.

ZNF429 ZNF726

1.78e-05925210360839
Pubmed

Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.

ZNF429 ZNF726

9.35e-05202522542606
Pubmed

A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci.

ADAMTS16 ZNF429

9.35e-052025215329828
Pubmed

Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.

ZNF429 ZNF726

9.35e-05202527479878
Pubmed

Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.

ZNF429 ZNF302

1.03e-04212527865130
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPM8 TRPC7

1.36e-042425233884443
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPM8 TRPC7

1.47e-042525216382100
Pubmed

An introduction to TRP channels.

TRPM8 TRPC7

1.72e-042725216460286
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPM8 TRPC7

2.58e-043325219834762
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

TRPM8 TRPC7

4.61e-044425219322198
InteractionTRIM28 interactions

ZNF430 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF738 ZNF257 ZNF726

2.79e-051474249int:TRIM28
InteractionZNF726 interactions

ZNF430 ZNF726

8.91e-0512242int:ZNF726
InteractionLTBP2 interactions

ZNF430 ZNF431 ZNF574

1.37e-0485243int:LTBP2
InteractionARHGAP24 interactions

ZNF100 ZNF680 ZNF91 ZNF257 ZNF726

2.32e-04486245int:ARHGAP24
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF429 ZNF430 ZNF431 ZNF100 ZNF91 ZNF493 ZNF738 ZNF257 ZNF43 ZNF726

3.81e-201222510chr19p12
Cytoband19p12

ZNF430 ZNF431 ZNF100 ZNF91 ZNF493 ZNF738 ZNF726

4.09e-149025719p12
Cytoband7q11.21

ZNF117 ZNF680

9.43e-04832527q11.21
CytobandEnsembl 112 genes in cytogenetic band chr7q11

ZNF117 ZNF680

9.52e-03271252chr7q11
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF429 ZNF430 ZNF431 ZNF117 ZNF100 ZNF680 ZNF91 ZNF302 ZNF493 ZNF257 ZNF43 ZNF726 ZNF574 ZNF667

1.93e-15718211428
GeneFamilyTransient receptor potential cation channels

TRPM8 TRPC7

4.77e-0428212249
CoexpressionZWANG_DOWN_BY_2ND_EGF_PULSE

ZNF429 ZNF431 ZNF117 ZNF302 ZNF493 ZNF738

4.69e-07321256M2615
CoexpressionWAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D

ZNF429 ZNF91 ZNF493 ZNF43 ZNF726 SPEG ZNF574

2.34e-06675257MM1073
CoexpressionYAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN

ZNF91 ZNF493 ZNF43 ZNF726 SPEG

9.65e-06309255MM1244
CoexpressionHE_LIM_SUN_FETAL_LUNG_C2_HSC_ELP_CELL

ZNF100 ZNF302 ZNF493 ZNF738 ZNF574

3.84e-05412255M45729
CoexpressionMIKKELSEN_NPC_ICP_WITH_H3K4ME3

ZNF429 ZNF91 ZNF493 ZNF43 ZNF726

9.33e-05497255MM863
CoexpressionCOATES_MACROPHAGE_M1_VS_M2_UP

ZNF91 ZNF493 ZNF43

1.24e-04102253MM749
CoexpressionCUI_TCF21_TARGETS_2_DN

ADAMTS16 ZNF91 ZNF493 ZNF43 ZNF726 SPEG

1.52e-04888256MM1018
CoexpressionDESCARTES_ORGANOGENESIS_WHITE_BLOOD_CELLS

ZNF91 ZNF493 ZNF43 ZNF726 CGAS

2.52e-04615255MM3641
CoexpressionGRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP

ZNF91 ZNF493 ZNF43 ZNF726 MSL2

2.54e-04616255MM977
CoexpressionTERAO_AOX4_TARGETS_SKIN_DN

ZNF91 ZNF43

3.25e-0428252MM925
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

ZNF430 ZNF117 ZNF302 ZNF257 ZNF43

3.39e-04656255M18979
CoexpressionMONNIER_POSTRADIATION_TUMOR_ESCAPE_DN

ZNF91 ZNF493 ZNF43 ZNF726

5.39e-04403254MM1029
CoexpressionDESCARTES_ORGANOGENESIS_NUETROPHILS

ZNF429 ZNF726

5.39e-0436252MM3668
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8|TCGA-Bladder / Sample_Type by Project: Shred V9

ZNF100 ZNF680 ZNF738 ZNF43 ZNF726

1.94e-081502551aa9320d97ff10994ea024751790524fe133aba9
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NARF ZNF431 ZNF91 ZNF738

3.13e-06183254af14da45267261e775dd6dab7a4c359b181e46f1
DiseaseTesticular Germ Cell Tumor

ZNF257 ZNF726

1.48e-0373232EFO_1000566
Diseaselongitudinal BMI measurement

ZNF257 KSR2

1.86e-0382232EFO_0005937
Diseasesleep duration

TRPC7 KSR2 MSL2

2.70e-03362233EFO_0005271

Protein segments in the cluster

PeptideGeneStartEntry
EEKCCRKDCLKLMKY

CGAS

401

Q8N884
AKLCMLDFKKDICKA

ADAMTS16

526

Q8TE57
GMLFGLKCKNCKLKC

KSR2

431

Q6VAB6
GCLDHIMKYKKKCVK

IL17RB

161

Q9NRM6
TCQHYVCKTCKGKKM

MSL2

61

Q9HCI7
CAYKKGICAMCGKKV

CRIPT

76

Q9P021
KKKLFECKECGKMFS

ZNF667

411

Q5HYK9
KKPFKCKKCGKSFCM

ZNF431

201

Q8TF32
KCKKCEKSFCMLLHL

ZNF100

206

Q8IYN0
KKPFKCKKCGKSFCM

ZNF738

201

Q8NE65
ALLKCKMHFDGRKCK

SPEG

1011

Q15772
KCSICGKMFKKKSHV

ZNF574

496

Q6ZN55
KKLFKCKECGKSFCM

ZNF43

171

P17038
KPFKCKNCVKSFCMF

ZNF726

171

A6NNF4
KCKKCDKSFCMLLHL

ZNF430

206

Q9H8G1
HTGKKCFKCKKCVKS

ZNF91

176

Q05481
KPFQCKKCGKSFCML

ZNF429

171

Q86V71
KKPFKCKKCGKSFCM

ZNF493

51

Q6ZR52
CKKCGKSFCMLLHLC

ZNF493

56

Q6ZR52
NKHFKCKECRKTFCM

ZNF117

106

Q03924
FYMVVKKCFKCCCKE

TRPM8

1021

Q7Z2W7
KKCFKCCCKEKNMES

TRPM8

1026

Q7Z2W7
VFKCKECGKSFCMLS

ZNF680

181

Q8NEM1
KMCLIKLCKSKAKSC

TRPC7

726

Q9HCX4
KTCKCKECGKSFCML

ZNF257

171

Q9Y2Q1
IHSMKKKYECNKCLK

ZNF302

441

Q9NR11
MKCEHCTRKECSKKT

NARF

1

Q9UHQ1