Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phenanthrene-9,10-epoxide hydrolase activity	AKR7L AKR7A3	1.69e-05	3	48	2	GO:0019119
GeneOntologyMolecularFunction	phenanthrene-epoxide hydrolase activity	AKR7L AKR7A3	1.69e-05	3	48	2	GO:0019118
GeneOntologyMolecularFunction	epoxide hydrolase activity	AKR7L AKR7A3	3.07e-04	11	48	2	GO:0004301
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	AKR7L AKR7A3	4.34e-04	13	48	2	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	AKR7L AKR7A3	4.34e-04	13	48	2	GO:0016803
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR7L AKR7A3	5.06e-04	14	48	2	GO:0004032
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE6C PDE6B	1.27e-03	22	48	2	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE6C PDE6B	1.51e-03	24	48	2	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE6C PDE6B	1.64e-03	25	48	2	GO:0004114
GeneOntologyMolecularFunction	alcohol dehydrogenase (NADP+) activity	AKR7L AKR7A3	1.91e-03	27	48	2	GO:0008106
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE6C PDE6B	1.91e-03	27	48	2	GO:0004112
GeneOntologyMolecularFunction	aldo-keto reductase (NADPH) activity	AKR7L AKR7A3	2.68e-03	32	48	2	GO:0004033
MousePheno	increased adiponectin level	TLR4 LRP6 ITPRID2	5.57e-05	30	35	3	MP:0004892
MousePheno	abnormal philtrum morphology	ALX1 DISP1	6.06e-05	5	35	2	MP:0012256
MousePheno	decreased liver triglyceride level	TLR4 HELZ2 LRP6 ITPRID2	8.56e-05	94	35	4	MP:0009356
MousePheno	abnormal upper lip morphology	ALX1 LRP6 DISP1	1.05e-04	37	35	3	MP:0012523
MousePheno	abnormal lip morphology	ALX1 LRP6 DISP1	1.90e-04	45	35	3	MP:0003769
Domain	GAF	PDE6C PDE6B	1.24e-04	7	46	2	PF01590
Domain	GAF	PDE6C PDE6B	1.65e-04	8	46	2	IPR003018
Domain	GAF	PDE6C PDE6B	1.65e-04	8	46	2	SM00065
Domain	-	PDE6C PDE6B	2.11e-04	9	46	2	3.30.450.40
Domain	GAF_dom-like	PDE6C PDE6B	2.11e-04	9	46	2	IPR029016
Domain	NADP_OxRdtase_dom	AKR7L AKR7A3	7.88e-04	17	46	2	IPR023210
Domain	Aldo_ket_red	AKR7L AKR7A3	7.88e-04	17	46	2	PF00248
Domain	Aldo/ket_red/Kv-b	AKR7L AKR7A3	7.88e-04	17	46	2	IPR001395
Domain	PDEase	PDE6C PDE6B	9.88e-04	19	46	2	IPR023088
Domain	PDEase_I	PDE6C PDE6B	1.21e-03	21	46	2	PF00233
Domain	PDEASE_I	PDE6C PDE6B	1.21e-03	21	46	2	PS00126
Domain	PDEase_CS	PDE6C PDE6B	1.21e-03	21	46	2	IPR023174
Domain	-	PDE6C PDE6B	1.33e-03	22	46	2	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE6C PDE6B	1.45e-03	23	46	2	IPR002073
Domain	HDc	PDE6C PDE6B	1.58e-03	24	46	2	SM00471
Domain	HD/PDEase_dom	PDE6C PDE6B	1.58e-03	24	46	2	IPR003607
Pathway	WP_AFLATOXIN_B1_METABOLISM	AKR7L AKR7A3	9.45e-05	6	36	2	MM15846
Pubmed	Cone Phosphodiesterase-6γ' Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits.	PDE6C PDE6B	1.94e-06	2	49	2	30038560
Pubmed	Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.	PDE6C PDE6B	1.94e-06	2	49	2	26085644
Pubmed	Calcium dynamics change in degenerating cone photoreceptors.	PDE6C PDE6B	1.94e-06	2	49	2	27402880
Pubmed	Preservation of Visual Cortex Plasticity in Retinitis Pigmentosa.	PDE6B TLR4	1.94e-06	2	49	2	31901258
Pubmed	Systematic spatiotemporal mapping reveals divergent cell death pathways in three mouse models of hereditary retinal degeneration.	PDE6C PDE6B	1.94e-06	2	49	2	31710697
Pubmed	[Purification of recombinant AKR7A5 protein and measurement of substrate specificity of AKR7A5 towards naphthoquinone and its derivatives].	AKR7L AKR7A3	5.83e-06	3	49	2	22863590
Pubmed	Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.	AKR7L AKR7A3	5.83e-06	3	49	2	12071861
Pubmed	Mouse aldo-keto reductase AKR7A5 protects V79 cells against 4-hydroxynonenal-induced apoptosis.	AKR7L AKR7A3	5.83e-06	3	49	2	16919859
Pubmed	Characterisation of a novel mouse liver aldo-keto reductase AKR7A5.	AKR7L AKR7A3	5.83e-06	3	49	2	12123834
Pubmed	Aldo-keto reductase 7A5 (AKR7A5) attenuates oxidative stress and reactive aldehyde toxicity in V79-4 cells.	AKR7L AKR7A3	5.83e-06	3	49	2	24590062
Pubmed	AKR7A5 knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice.	AKR7L AKR7A3	5.83e-06	3	49	2	39365156
Pubmed	Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation.	PDE6B TLR4	5.83e-06	3	49	2	28885615
Pubmed	Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.	ALX1 OCA2 DISP1	5.91e-06	25	49	3	29475039
Pubmed	Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice.	PDE6C PDE6B	1.16e-05	4	49	2	31825309
Pubmed	Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.	AKR7L AKR7A3	1.16e-05	4	49	2	12879023
Pubmed	Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.	PDE6C PDE6B	1.16e-05	4	49	2	23033484
Pubmed	Rod phosphodiesterase-6 (PDE6) catalytic subunits restore cone function in a mouse model lacking cone PDE6 catalytic subunit.	PDE6C PDE6B	1.16e-05	4	49	2	21799013
Pubmed	Long non-coding RNA LncTUG1 regulates favourable compression force-induced cementocytes mineralization via PU.1/TLR4/SphK1 signalling.	SPHK1 TLR4	1.16e-05	4	49	2	38318762
Pubmed	The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1α protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6.	SPHK1 TLR4	1.94e-05	5	49	2	20661259
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	NUP85 CCDC168 ITPRID2 CNOT1	2.79e-05	123	49	4	26912792
Pubmed	Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit.	PDE6C PDE6B	2.91e-05	6	49	2	19798052
Pubmed	A mouse model for studying cone photoreceptor pathologies.	PDE6C PDE6B	2.91e-05	6	49	2	25034607
Pubmed	Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.	MYCBP2 LRP6 OCA2	3.34e-05	44	49	3	22645275
Pubmed	Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration.	PDE6C PDE6B	4.07e-05	7	49	2	25392995
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	NUP85 NOM1 RTL9 NCAPD2 CDT1 CNOT1	4.98e-05	469	49	6	27634302
Pubmed	Gut-liver axis calibrates intestinal stem cell fitness.	TLR4 LRP6	5.42e-05	8	49	2	38280375
Pubmed	Genetic variation associated with preterm birth: a HuGE review.	TLR4 F5	1.06e-04	11	49	2	16301860
Pubmed	A forward genetic screen in mice identifies mutants with abnormal cortical patterning.	MYCBP2 LRP6	1.06e-04	11	49	2	23968836
Pubmed	Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors.	ALX1 NCAPD2	1.06e-04	11	49	2	20589882
Pubmed	The mouse Rhl1 and Rhag genes: sequence, organization, expression, and chromosomal mapping.	AKR7L AKR7A3	1.27e-04	12	49	2	10495887
Pubmed	Retinal degeneration mutants in the mouse.	PDE6C PDE6B	1.50e-04	13	49	2	11853768
Pubmed	DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.	PDE6C PDE6B	1.75e-04	14	49	2	21297615
Pubmed	In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development.	PDE6C PDE6B	1.75e-04	14	49	2	16868010
Pubmed	Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss.	TLR4 LRP6	1.75e-04	14	49	2	19015224
Pubmed	Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.	TLR4 F5	1.75e-04	14	49	2	20078877
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	MYCBP2 AKR7L AJM1 SFXN3 HNRNPM BRSK2 AKR7A3 CNOT1	1.77e-04	1139	49	8	36417873
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	NCAPD2 FRYL ITPRID2 CNOT1	1.91e-04	202	49	4	33005030
Pubmed	Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.	TENT4A OCA2	2.02e-04	15	49	2	23548203
Pubmed	Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.	AKR7L AKR7A3	3.64e-04	20	49	2	9828140
Pubmed	A series of recombinant inbred strains between the BALB/cHeA and STS/A mouse strains.	PDE6B HAO1	4.01e-04	21	49	2	4042679
Pubmed	Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3.	PDE6C PDE6B	4.01e-04	21	49	2	27740716
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	NUP85 HNRNPM HELZ2 CDT1	4.28e-04	250	49	4	33536335
Pubmed	The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis.	TLR4 F5	4.83e-04	23	49	2	20207250
Pubmed	Overview of PDEs and their regulation.	PDE6C PDE6B	5.71e-04	25	49	2	17307970
Pubmed	Holoprosencephaly Overview	CNOT1 DISP1	5.71e-04	25	49	2	20301702
Pubmed	Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994.	TLR4 F5	6.18e-04	26	49	2	21054877
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	SFXN3 RFX7 CNOT1	6.90e-04	122	49	3	30773093
Pubmed	Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.	ZNF875 HNRNPM	8.25e-04	30	49	2	25678563
Pubmed	The genomic basis of cerebral palsy: a HuGE systematic literature review.	TLR4 F5	1.06e-03	34	49	2	19238444
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	IFI30 FRYL RFX7	1.07e-03	142	49	3	11812828
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	MYCBP2 HNRNPM FRYL ITPRID2 ADAM12	1.13e-03	560	49	5	21653829
Pubmed	Defining the membrane proteome of NK cells.	NUP85 MYCBP2 HNRNPM NCAPD2 HELZ2 F5 CNOT1	1.19e-03	1168	49	7	19946888
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	NUP85 HELZ2 ITPRID2 CNOT1	1.23e-03	332	49	4	25693804
Pubmed	Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.	SPHK1 TLR4	1.25e-03	37	49	2	29044125
Pubmed	Requirement of the Mowat-Wilson Syndrome Gene Zeb2 in the Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.	PDE6C PDE6B	1.39e-03	39	49	2	29922981
Pubmed	Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.	PKD1L1 F5 CNOT1	1.40e-03	156	49	3	22008794
Cytoband	19q13.1	CATSPERG CHST8	1.60e-03	55	49	2	19q13.1
Cytoband	1p36.13	AKR7L AKR7A3	1.66e-03	56	49	2	1p36.13
GeneFamily	Phosphodiesterases	PDE6C PDE6B	5.81e-04	24	27	2	681
Disease	PEELING SKIN SYNDROME	SERPINB8 CHST8	1.49e-05	4	47	2	C1849193
Disease	peeling skin syndrome (is_implicated_in)	SERPINB8 CHST8	3.71e-05	6	47	2	DOID:0060283 (is_implicated_in)
Disease	glycochenodeoxycholate measurement	SLC10A1 ADAM12	3.33e-04	17	47	2	EFO_0010490
Disease	myocardial infarction (is_implicated_in)	KIF6 TLR4 F5	5.34e-04	99	47	3	DOID:5844 (is_implicated_in)
Disease	facial morphology measurement	KIF6 CFAP251 ALX1 OCA2 CHST8	8.54e-04	466	47	5	EFO_0007841
Disease	D dimer measurement	CATSPERG F5	1.05e-03	30	47	2	EFO_0004507
Disease	retinal degeneration (implicated_via_orthology)	PDE6C PDE6B	1.27e-03	33	47	2	DOID:8466 (implicated_via_orthology)
Disease	beta-nerve growth factor measurement	F5 CHST8	2.05e-03	42	47	2	EFO_0008035
Disease	retinal nerve fibre layer thickness measurement	KIF6 OCA2	2.15e-03	43	47	2	EFO_0600004
Disease	optic disc area measurement	KIF6 F5	2.35e-03	45	47	2	EFO_0006937
Disease	pneumonia	HELZ2 F5	2.56e-03	47	47	2	EFO_0003106
Disease	type 2 diabetes mellitus (is_implicated_in)	KIF6 SPHK1 TLR4	2.57e-03	171	47	3	DOID:9352 (is_implicated_in)
Disease	Fibrosis	SPHK1 TLR4	2.90e-03	50	47	2	C0016059
Disease	Cirrhosis	SPHK1 TLR4	2.90e-03	50	47	2	C1623038

Protein segments in the cluster

Peptide	Gene	Start	Entry
MDNCNSLRMSPVKGM	ALX1	96	Q15699
MPSLRHSRMGSMFSS	CATSPERG	1126	Q6ZRH7
AMEMGRRMDAPTSAA	AKR7L	16	Q8NHP1
AMEMGRRMDAPTSAA	AKR7A3	16	O95154
MAFAPMVMRLHCGAT	B4GALNT3	901	Q6L9W6
TGRPFMCMIMAASEP	AJM1	946	C9J069
RMVGSCCTIMSPGEM	CDT1	481	Q9H211
FQGTTIGMAPIMSMC	ADAM12	311	O43184
IGMAPIMSMCTADQS	ADAM12	316	O43184
AALTTFVAGAMMMPS	DISP1	1086	Q96F81
DSCPEGNGIMAMAMT	CFAP251	341	Q8TBY9
RLGFPMMVVSCTVGM	OCA2	811	Q04671
SPEVAERACRMMNGM	HNRNPM	701	P52272
CMEMMTGRLSKCGSP	BRSK2	651	Q8IWQ3
SAGICRIMGDLMRTM	NUP85	226	Q9BW27
AMMMTACDLSAITKP	PDE6B	711	P35913
AMMMTACDLSAITKP	PDE6C	716	P51160
VGRPMCMTSVQMSNK	FRYL	526	O94915
VSMPICVGATAMQRM	HAO1	71	Q9UJM8
MMTSVLRDSLGGNCM	KIF6	301	Q6ZMV9
RMLCPRMKGDGETMT	LRP6	1396	O75581
MAIISGMNMSPVSRL	RASGEF1B	306	Q0VAM2
VRMPSPFRSSALMGM	ITPRID2	1036	P28290
STMGLSESCLMTAMA	OR5AN1	106	Q8NGI8
MKAMTSGYRPSMLCI	TENT4A	446	Q5XG87
VMTTCSTFCALGMMP	SLC10A1	121	Q14973
METDCNPMELSSMSG	GSKIP	1	Q9P0R6
SPDTIMECAMGDRGM	IFI30	171	P13284
ACVNMRMSMPEALAA	AMDHD1	351	Q96NU7
DISMTNLGSMACPIM	CCDC168	3026	Q8NDH2
MFCHVAGSPDRDMSM	HELZ2	781	Q9BYK8
MASCSSMMRHSLPSI	PKD1L1	2636	Q8TDX9
TGCLTAMVEMMSVLP	OR13F1	151	Q8NGS4
PASGSMSMLQMRAPV	RTL9	531	Q8NET4
MPQMRTMASGLTSAA	RTL9	551	Q8NET4
SMPLTRSTASGGMSM	RTL9	846	Q8NET4
RSTASGGMSMPLMRA	RTL9	851	Q8NET4
MMPTASGDMCTLPVR	RTL9	876	Q8NET4
RMSAQVPMNMTITGC	SFXN3	91	Q9BWM7
LIMDRDCRMPMGLST	F5	1901	P12259
MMMCAATASPAAASS	MYCBP2	1	O75592
GACVTASAMPSRLMM	NOM1	406	Q5C9Z4
SPMSISSALAMVFMG	SERPINB8	31	P50452
SGMMCGSDSEMFNIP	SPAG17	621	Q6Q759
MTLRPGTMRLACMFS	CHST8	1	Q9H2A9
RCSSVMLLGMMARGK	NCAPD2	771	Q15021
ARIRGMSNCSMTPMT	C12orf54	61	Q6X4T0
GMAMITCREPLLMSI	CNOT1	1451	A5YKK6
ITSCSISDPMLSFMM	WBP2NL	61	Q6ICG8
SMAALTVMAAAPAGM	RFX7	161	Q2KHR2
EMFAAPMGRCAAGVM	SPHK1	271	Q9NYA1
MRVNHTVSTMLPTCM	ZNF875	1	P10072
MMSASRLAGTLIPAM	TLR4	1	O00206
RSLGPIMASMADRNM	ZCCHC12	31	Q6PEW1