Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	microfilament motor activity	MYH2 MYH3 MYO6	1.10e-04	38	49	3	GO:0000146
Domain	Peptidase_S8_Asp-AS	PCSK6 PCSK4	1.00e-04	6	49	2	IPR023827
Domain	Liprin	PPFIA4 PPFIA2	1.00e-04	6	49	2	IPR029515
Domain	Galactose-bd-like	PTPRK PCSK6 PTPRU PCSK4	1.07e-04	94	49	4	IPR008979
Domain	Myosin_head_motor_dom	MYH2 MYH3 MYO6	1.34e-04	38	49	3	IPR001609
Domain	MYOSIN_MOTOR	MYH2 MYH3 MYO6	1.34e-04	38	49	3	PS51456
Domain	Myosin_head	MYH2 MYH3 MYO6	1.34e-04	38	49	3	PF00063
Domain	MYSc	MYH2 MYH3 MYO6	1.34e-04	38	49	3	SM00242
Domain	PrprotnconvertsP	PCSK6 PCSK4	1.40e-04	7	49	2	IPR002884
Domain	-	AIFM1 TXNRD3	1.40e-04	7	49	2	3.30.390.30
Domain	P_proprotein	PCSK6 PCSK4	1.40e-04	7	49	2	PF01483
Domain	S8_pro-domain	PCSK6 PCSK4	1.40e-04	7	49	2	IPR032815
Domain	-	PCSK6 PCSK4	1.40e-04	7	49	2	3.30.70.850
Domain	S8_pro-domain	PCSK6 PCSK4	1.40e-04	7	49	2	PF16470
Domain	Pyr_nucl-diS_OxRdtase_dimer	AIFM1 TXNRD3	1.87e-04	8	49	2	IPR004099
Domain	FAD/NAD-linked_Rdtase_dimer	AIFM1 TXNRD3	1.87e-04	8	49	2	IPR016156
Domain	Peptidase_S8_His-AS	PCSK6 PCSK4	2.40e-04	9	49	2	IPR022398
Domain	Peptidase_S8_Ser-AS	PCSK6 PCSK4	2.40e-04	9	49	2	IPR023828
Domain	Peptidase_S8_subtilisin-rel	PCSK6 PCSK4	2.99e-04	10	49	2	IPR015500
Domain	SUBTILASE_ASP	PCSK6 PCSK4	2.99e-04	10	49	2	PS00136
Domain	SUBTILASE_HIS	PCSK6 PCSK4	2.99e-04	10	49	2	PS00137
Domain	SUBTILASE_SER	PCSK6 PCSK4	2.99e-04	10	49	2	PS00138
Domain	-	PCSK6 PCSK4	3.65e-04	11	49	2	3.40.50.200
Domain	Peptidase_S8/S53_dom	PCSK6 PCSK4	3.65e-04	11	49	2	IPR000209
Domain	Peptidase_S8	PCSK6 PCSK4	3.65e-04	11	49	2	PF00082
Domain	Myosin_N	MYH2 MYH3	6.93e-04	15	49	2	PF02736
Domain	Myosin_N	MYH2 MYH3	6.93e-04	15	49	2	IPR004009
Domain	MAM_1	PTPRK PTPRU	7.90e-04	16	49	2	PS00740
Domain	IQ	MYH2 MYH3 MYO6	8.56e-04	71	49	3	PF00612
Domain	Propept_inh	PCSK6 PCSK4	8.94e-04	17	49	2	IPR009020
Domain	MAM	PTPRK PTPRU	8.94e-04	17	49	2	SM00137
Domain	MAM	PTPRK PTPRU	1.00e-03	18	49	2	PF00629
Domain	Myosin_tail_1	MYH2 MYH3	1.00e-03	18	49	2	PF01576
Domain	Myosin_tail	MYH2 MYH3	1.00e-03	18	49	2	IPR002928
Domain	MAM_dom	PTPRK PTPRU	1.00e-03	18	49	2	IPR000998
Domain	MAM_2	PTPRK PTPRU	1.00e-03	18	49	2	PS50060
Domain	Furin_repeat	PCSK6 PCSK4	1.00e-03	18	49	2	IPR006212
Domain	FU	PCSK6 PCSK4	1.00e-03	18	49	2	SM00261
Domain	Myosin-like_IQ_dom	MYH2 MYH3	1.12e-03	19	49	2	IPR027401
Domain	-	MYH2 MYH3	1.12e-03	19	49	2	4.10.270.10
Domain	Pyr_redox_2	AIFM1 TXNRD3	1.12e-03	19	49	2	PF07992
Domain	IQ	MYH2 MYH3 MYO6	1.25e-03	81	49	3	SM00015
Domain	IQ_motif_EF-hand-BS	MYH2 MYH3 MYO6	1.70e-03	90	49	3	IPR000048
Domain	IQ	MYH2 MYH3 MYO6	1.87e-03	93	49	3	PS50096
Domain	PTPc	PTPRK PTPRU	4.01e-03	36	49	2	SM00194
Domain	TYR_PHOSPHATASE_PTP	PTPRK PTPRU	4.70e-03	39	49	2	PS50055
Domain	PTPase_domain	PTPRK PTPRU	5.18e-03	41	49	2	IPR000242
Domain	Y_phosphatase	PTPRK PTPRU	5.18e-03	41	49	2	PF00102
Domain	SAM_2	PPFIA4 PPFIA2	5.69e-03	43	49	2	PF07647
Pubmed	Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.	PPFIA4 PPFIA2 PTPRU	5.73e-07	12	49	3	9624153
Pubmed	The association between expression of IFIT1 in podocytes of MRL/lpr mice and the renal pathological changes it causes: An animal study.	IFIT1B IFIT1	1.94e-06	2	49	2	27823966
Pubmed	2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.	IFIT1B IFIT1	1.94e-06	2	49	2	22589727
Pubmed	Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.	IFIT1B IFIT1	1.94e-06	2	49	2	33454014
Pubmed	A viral RNA structural element alters host recognition of nonself RNA.	IFIT1B IFIT1	1.94e-06	2	49	2	24482115
Pubmed	Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA.	IFIT1B IFIT1	1.94e-06	2	49	2	24098121
Pubmed	Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals.	IFIT1B IFIT1	1.94e-06	2	49	2	27240734
Pubmed	IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon.	IFIT1B IFIT1	1.94e-06	2	49	2	25927359
Pubmed	IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages.	IFIT1B IFIT1	1.94e-06	2	49	2	30282041
Pubmed	Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families.	IFIT1B IFIT1	1.94e-06	2	49	2	26157117
Pubmed	Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway.	IFIT1B IFIT1	1.94e-06	2	49	2	26459629
Pubmed	Overexpression of IFIT1 protects against LPS-induced acute lung injury via regulating CCL5-p65NF-κB signaling.	IFIT1B IFIT1	1.94e-06	2	49	2	36446235
Pubmed	Identification and validation of Ifit1 as an important innate immune bottleneck.	IFIT1B IFIT1	1.94e-06	2	49	2	22745654
Pubmed	Ifit1 inhibits Japanese encephalitis virus replication through binding to 5' capped 2'-O unmethylated RNA.	IFIT1B IFIT1	1.94e-06	2	49	2	23824812
Pubmed	Novel characteristics of the function and induction of murine p56 family proteins.	IFIT1B IFIT1	5.83e-06	3	49	2	18768971
Pubmed	Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) accelerates osteoclast formation by regulating signal transducer and activator of transcription 3 (STAT3) signalling.	IFIT1B IFIT1	5.83e-06	3	49	2	35034537
Pubmed	Structure, chromosome localization, and regulation of expression of the interferon-regulated mouse Ifi54/Ifi56 gene family.	IFIT1B IFIT1	5.83e-06	3	49	2	7896268
Pubmed	The interaction between interferon-induced protein with tetratricopeptide repeats-1 and eukaryotic elongation factor-1A.	IFIT1B IFIT1	5.83e-06	3	49	2	19856081
Pubmed	The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins.	IFIT1B IFIT1	5.83e-06	3	49	2	30232164
Pubmed	Mouse p56 blocks a distinct function of eukaryotic initiation factor 3 in translation initiation.	IFIT1B IFIT1	5.83e-06	3	49	2	15561726
Pubmed	The synaptic vesicle cycle.	SV2A PPFIA4 PPFIA2	1.15e-05	31	49	3	15217342
Pubmed	Tissue-specific and inducer-specific differential induction of ISG56 and ISG54 in mice.	IFIT1B IFIT1	1.16e-05	4	49	2	17553874
Pubmed	Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis.	AIFM1 NDUFB8	1.16e-05	4	49	2	26004228
Pubmed	Interferon-induced protein Ifit2 protects mice from infection of the peripheral nervous system by vesicular stomatitis virus.	IFIT1B IFIT1	1.16e-05	4	49	2	24991014
Pubmed	Sendai virus pathogenesis in mice is prevented by Ifit2 and exacerbated by interferon.	IFIT1B IFIT1	1.16e-05	4	49	2	25231314
Pubmed	Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages.	IFIT1B IFIT1	1.16e-05	4	49	2	24198415
Pubmed	Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity.	IFIT1B IFIT1	1.16e-05	4	49	2	24478444
Pubmed	Coordinated regulation and widespread cellular expression of interferon-stimulated genes (ISG) ISG-49, ISG-54, and ISG-56 in the central nervous system after infection with distinct viruses.	IFIT1B IFIT1	1.16e-05	4	49	2	17079283
Pubmed	Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.	MYH2 MYH3	1.16e-05	4	49	2	20357587
Pubmed	Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3.	IFIT1B IFIT1	1.16e-05	4	49	2	37496288
Pubmed	Interferon-induced Ifit proteins: their role in viral pathogenesis.	IFIT1B IFIT1	1.16e-05	4	49	2	25428874
Pubmed	Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development.	PTPRK PTPRU	1.16e-05	4	49	2	9510027
Pubmed	The glucocorticoid attenuated response genes GARG-16, GARG-39, and GARG-49/IRG2 encode inducible proteins containing multiple tetratricopeptide repeat domains.	IFIT1B IFIT1	1.16e-05	4	49	2	8660659
Pubmed	The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease.	IFIT1B IFIT1	1.94e-05	5	49	2	29879406
Pubmed	Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.	MYH2 MYH3	1.94e-05	5	49	2	3829126
Pubmed	The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing.	PPFIA4 PPFIA2	1.94e-05	5	49	2	19013515
Pubmed	Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.	MYH2 MYH3	1.94e-05	5	49	2	6196357
Pubmed	Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome.	MYH2 MYH3	1.94e-05	5	49	2	6879174
Pubmed	Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members.	IFIT1B IFIT1	1.94e-05	5	49	2	27137933
Pubmed	Ifit2 Is a Restriction Factor in Rabies Virus Pathogenicity.	IFIT1B IFIT1	1.94e-05	5	49	2	28637751
Pubmed	The new enzymology of precursor processing endoproteases.	PCSK6 PCSK4	1.94e-05	5	49	2	1429684
Pubmed	Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis.	IFIT1B IFIT1	1.94e-05	5	49	2	22615570
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH2 MYH3	2.91e-05	6	49	2	10077619
Pubmed	Analyses of the spatiotemporal expression and subcellular localization of liprin-α proteins.	PPFIA4 PPFIA2	2.91e-05	6	49	2	21618221
Pubmed	Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation.	IFIT1B IFIT1	2.91e-05	6	49	2	32277054
Pubmed	The broad-spectrum antiviral functions of IFIT and IFITM proteins.	IFIT1B IFIT1	2.91e-05	6	49	2	23237964
Pubmed	Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.	MYH2 MYH3	2.91e-05	6	49	2	10444070
Pubmed	Cloning and chromosomal location of human genes inducible by type I interferon.	IFIT1B IFIT1	2.91e-05	6	49	2	3175763
Pubmed	Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.	MYH2 MYH3	2.91e-05	6	49	2	1728586
Pubmed	Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.	MYH2 MYH3	2.91e-05	6	49	2	10588881
Pubmed	2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members.	IFIT1B IFIT1	4.07e-05	7	49	2	21085181
Pubmed	Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation.	IFIT1B IFIT1	4.07e-05	7	49	2	31083674
Pubmed	RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.	IFIT1B IFIT1	4.07e-05	7	49	2	33983932
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH2 MYH3	4.07e-05	7	49	2	35210422
Pubmed	ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.	MYH2 MYH3	4.07e-05	7	49	2	29758057
Pubmed	Proteolytic processing in the secretory pathway.	PCSK6 PCSK4	4.07e-05	7	49	2	10409610
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH2 MYH3	4.07e-05	7	49	2	16819597
Pubmed	Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting.	PPFIA4 PPFIA2	4.07e-05	7	49	2	11931740
Pubmed	The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.	PCSK6 PCSK4	4.07e-05	7	49	2	7819324
Pubmed	Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.	PCSK6 PCSK4	5.42e-05	8	49	2	7782070
Pubmed	Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.	PCSK6 PCSK4	5.42e-05	8	49	2	9885250
Pubmed	The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.	PCSK6 PCSK4	6.96e-05	9	49	2	23775089
Pubmed	Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.	PPFIA4 PPFIA2	6.96e-05	9	49	2	12629171
Pubmed	The activation and physiological functions of the proprotein convertases.	PCSK6 PCSK4	6.96e-05	9	49	2	18343183
Pubmed	Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria.	IFIT1B IFIT1	6.96e-05	9	49	2	23853600
Pubmed	Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development.	IFIT1B IFIT1	6.96e-05	9	49	2	30380406
Pubmed	SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.	PCSK6 PCSK4	6.96e-05	9	49	2	8698813
Pubmed	An essential role for Cmtr2 in mammalian embryonic development.	IFIT1B IFIT1	6.96e-05	9	49	2	39094818
Pubmed	Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.	PPFIA4 PPFIA2	6.96e-05	9	49	2	12923177
Pubmed	The prohormone theory and the proprotein convertases: it is all about serendipity.	PCSK6 PCSK4	6.96e-05	9	49	2	21805236
Pubmed	The proprotein convertases, 20 years later.	PCSK6 PCSK4	6.96e-05	9	49	2	21805237
Pubmed	The biology and therapeutic targeting of the proprotein convertases.	PCSK6 PCSK4	6.96e-05	9	49	2	22679642
Pubmed	Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.	PCSK6 PCSK4	8.69e-05	10	49	2	16163737
Pubmed	Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity.	IFIT1B IFIT1	8.69e-05	10	49	2	26633895
Pubmed	Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice.	MYH2 MYH3	8.69e-05	10	49	2	8950513
Pubmed	Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.	MYH2 MYH3	1.06e-04	11	49	2	16024798
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	AIFM1 BTAF1 POLDIP2 TRRAP	1.17e-04	178	49	4	27637333
Pubmed	Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development.	MYH2 MYH3	1.27e-04	12	49	2	28600496
Pubmed	Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.	IFIT1B IFIT1	1.27e-04	12	49	2	28874170
Pubmed	The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.	MYH2 MYH3	1.50e-04	13	49	2	8948582
Pubmed	Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies.	MYH2 MYH3	1.50e-04	13	49	2	7797078
Pubmed	Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.	MYH2 MYH3	1.50e-04	13	49	2	8404542
Pubmed	Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4.	MYH2 MYH3	1.50e-04	13	49	2	10694423
Pubmed	Postnatal gene expression in the normal mouse cornea by SAGE.	IFIT1B IFIT1	1.75e-04	14	49	2	14744882
Pubmed	Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.	MYH2 MYH3	1.75e-04	14	49	2	27184118
Pubmed	Glucocorticoid-attenuated response genes encode intercellular mediators, including a new C-X-C chemokine.	IFIT1B IFIT1	1.75e-04	14	49	2	7622488
Pubmed	Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.	MYH2 MYH3	2.02e-04	15	49	2	24852826
Pubmed	Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.	IFIT1B IFIT1	2.02e-04	15	49	2	24362933
Pubmed	Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H.	MYH2 MYH3	2.61e-04	17	49	2	16124007
Pubmed	The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.	IFIT1B IFIT1	2.93e-04	18	49	2	27001747
Pubmed	Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta.	MYH3 PCSK6	3.27e-04	19	49	2	22987638
Pubmed	Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.	IPO9 AIFM1 POLDIP2	3.32e-04	95	49	3	35896951
Pubmed	The ULK1-FBXW5-SEC23B nexus controls autophagy.	FBXL3 SEC13	3.64e-04	20	49	2	30596474
Pubmed	mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.	PPFIA4 PPFIA2	3.64e-04	20	49	2	23791195
Pubmed	Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair.	IFIT1B IFIT1	3.64e-04	20	49	2	34655526
Pubmed	A mammalian-specific Alex3/Gαq protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival.	SV2A NDUFB8	4.01e-04	21	49	2	38320000
Pubmed	An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.	IFIT1B IFIT1	4.01e-04	21	49	2	19158679
Pubmed	ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.	IFIT1B IFIT1	4.01e-04	21	49	2	35859175
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	CMKLR2 MYH3 INHBC SV2A CD101 NMUR1 CYB561A3 ANO3	4.15e-04	1293	49	8	15342556
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	MYH2 MYH3	4.41e-04	22	49	2	24301466
Cytoband	10q23.31	IFIT1B IFIT1	6.13e-04	34	49	2	10q23.31
Cytoband	Ensembl 112 genes in cytogenetic band chr10q23	IFIT1B BTAF1 IFIT1	1.20e-03	195	49	3	chr10q23
Cytoband	Ensembl 112 genes in cytogenetic band chr2q37	AGXT NMUR1 SH3BP4	1.84e-03	226	49	3	chr2q37
Cytoband	1q32.1	IPO9 PPFIA4	6.00e-03	108	49	2	1q32.1
Cytoband	17p13.1	MYH2 MYH3	7.12e-03	118	49	2	17p13.1
GeneFamily	Proprotein convertase subtilisin/kexin family	PCSK6 PCSK4	1.15e-04	9	33	2	973
GeneFamily	Myosin heavy chains	MYH2 MYH3	3.34e-04	15	33	2	1098
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRK PTPRU	6.64e-04	21	33	2	813
GeneFamily	Fibronectin type III domain containing	IFNGR2 PTPRK PTPRU	3.05e-03	160	33	3	555
GeneFamily	Sterile alpha motif domain containing	PPFIA4 PPFIA2	1.12e-02	88	33	2	760
GeneFamily	WD repeat domain containing	GEMIN5 DMXL1 SEC13	1.19e-02	262	33	3	362
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	IFIT1B IFIT1	1.86e-02	115	33	2	769
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 AMPD3 HSPBAP1 CD101 FBXL3	6.11e-07	148	49	5	ba277c898678dd36f8dc1d681301c71901b89055
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN12 AMPD3 HSPBAP1 CD101 FBXL3	6.11e-07	148	49	5	b4632029ebd14969bda59a1bd1454eadb8efe563
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYH2 MYH3 PTPRU ANO3 SH3BP4	9.54e-07	162	49	5	4d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCell	TCGA-Mesothelium\|World / Sample_Type by Project: Shred V9	CMKLR2 UPK1B SLC9C2 PKHD1L1	1.27e-05	130	49	4	3ef1733eb57e2a9a3298ce0d65401f19e2084df1
ToppCell	droplet-Liver-Npc-21m-Epithelial-Hepatocyte_(Midlobular)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELENBP1 AIFM1 AGXT NMUR1	1.85e-05	143	49	4	0cd332c128710291a39957d3da22953352f5c382
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CMKLR2 MYH2 MYH3 ANO3	2.95e-05	161	49	4	66554f59eaea4ba55a6c6724f9368e24e99c91e9
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYH2 MYH3 ANO3 SH3BP4	3.02e-05	162	49	4	58da6bc04cdac0002b0e6a751c96ff95e1a7f70f
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Brinp3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYH2 MYH3 ANO3 SH3BP4	3.10e-05	163	49	4	b0aa4a620bd58011225b42ea6dda04e3101ba342
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial-RGCs_early_2\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	IFIT1B AGXT GDPD2 IFIT1	3.25e-05	165	49	4	e460e03992781073cd836a655f15dda3157cea55
ToppCell	droplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPBAP1 PPFIA4 CYB561A3 SH3BP4	3.41e-05	167	49	4	a66552667aa6e8992c159df27a57c2e8ae14a9ce
ToppCell	droplet-Liver-Npc-18m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPBAP1 PPFIA4 CYB561A3 SH3BP4	3.41e-05	167	49	4	1248f809afbcccb42ce9e29cfe6fa1f6f6b65005
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CMKLR2 PPFIA2 PCSK6 ANO3	4.56e-05	180	49	4	c4068fe47408cfd899131a85fa4b7e5908926f94
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELENBP1 UPK1B PKHD1L1 SH3BP4	5.74e-05	191	49	4	5343a527de6b0f852f45020a91f5b4869e78f13a
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELENBP1 UPK1B PKHD1L1 SH3BP4	5.74e-05	191	49	4	a25a5f9a380031fdaf57677a079f97a90f0550c0
ToppCell	(1)_T_cell-(17)_gd_T\|(1)_T_cell / shred on Cell_type and subtype	CAPN12 MYO6 CD101 NMUR1	6.73e-05	199	49	4	4b7d8453d9c6723e51e0c2d6cbca6b7e2d4950dc
ToppCell	Severe-Epithelial-Epithelial-\|Severe / Condition, Lineage, Cell class and cell subclass	SELENBP1 PTPRK MYO6 UPK1B	6.86e-05	200	49	4	8669ce08f93eefb8ac970e30cdc4b1f908023c54
ToppCell	Severe-Epithelial\|Severe / Condition, Lineage, Cell class and cell subclass	SELENBP1 PTPRK MYO6 UPK1B	6.86e-05	200	49	4	6ead9db88568bb829d564a6d8e85f71fd765bac0
ToppCell	Severe-Epithelial-Epithelial\|Severe / Condition, Lineage, Cell class and cell subclass	SELENBP1 PTPRK MYO6 UPK1B	6.86e-05	200	49	4	3bd1ce2793651c9badd69f011d2531183594e5f4
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH2 MYH3	1.02e-04	10	45	2	DOID:0110454 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH2 MYH3	1.02e-04	10	45	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH2 MYH3	1.02e-04	10	45	2	DOID:3429 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH2 MYH3	1.02e-04	10	45	2	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH2 MYH3	1.02e-04	10	45	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH2 MYH3	1.02e-04	10	45	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH2 MYH3	1.02e-04	10	45	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH2 MYH3	1.02e-04	10	45	2	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH2 MYH3	1.49e-04	12	45	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH2 MYH3	1.49e-04	12	45	2	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH2 MYH3	1.76e-04	13	45	2	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH2 MYH3	2.36e-04	15	45	2	DOID:0050646 (implicated_via_orthology)
Disease	antiphospholipid syndrome	PTPRU SH3BP4	6.14e-04	24	45	2	EFO_0002689

Protein segments in the cluster

Peptide	Gene	Start	Entry
WRCGNWPEEHYAMVA	AHSA2P	236	Q719I0
IMTRHPENYQWENWS	C2orf69	116	Q8N8R5
YWHQSMFWSDLGPDV	AIFM1	476	O95831
WHVDWLDEYQPGMFR	DMXL1	506	Q9Y485
WFIQHKVYSPNMRWI	AMPD3	456	Q01432
YERWARWGMWYKHQP	ANO3	366	Q9BYT9
GMREAQNSHVYWWRY	POLDIP2	251	Q9Y2S7
FGICWAPFHADRVMW	NMUR1	306	Q9HB89
WHDWIIQPEGYAMNF	INHBC	261	P55103
WVGMPAWYVAACRAN	PPFIA4	841	O75335
EGYNNWVFMSTHFWD	PCSK4	531	Q6UW60
NDPIWSNMWYLHCGD	PCSK6	161	P29122
QYNIRSFMNVKHWPW	MYH2	821	Q9UKX2
VAEPYGSWAFMWQQV	METTL7B	176	Q6UX53
HNFNEFLFRRWGHWM	GDPD2	66	Q9HCC8
WGEPMHWHLDMYNRN	NDUFB8	101	O95169
PEMVYDFWRMVWQEH	PTPRU	966	Q92729
FCNMVFDWPARHWNA	HSPBAP1	46	Q96EW2
AGVFHFQLWQFGRWM	CAPN12	136	Q6ZSI9
MYWCRVAEWQLHGHP	CD101	906	Q93033
VQYVVAAACPWMGAW	BTAF1	596	O14981
WRGQFCRWQLNPGMY	GBA2	166	Q9HCG7
WNQVFHMPDLWRCFE	FBXL3	66	Q9UKT7
GKYAWAMFLDRPQQW	DPP9	361	Q86TI2
VTWGNFAWVYYHMGR	IFIT1B	96	Q5T764
VTWGNFAWMYYHMGR	IFIT1	96	P09914
WVTMPWFQHYRNVTV	IFNGR2	126	P38484
WHDEQGHNGLWYVMQ	IPO9	731	Q96P70
AWNGSIYMFNWHPVL	CYB561A3	36	Q8NBI2
YGDMNHEWIGNEWLP	PPFIA2	1016	O75334
PVHETVYDFWRMIWQ	PTPRK	961	Q15262
MARDWPDARGIWHNY	CKMT2	241	P17540
HEGPVWQVAWAHPMY	SEC13	56	P55735
WQVAWAHPMYGNILA	SEC13	61	P55735
WLANFWGCDDQPRMY	AGXT	246	P21549
YWMHFCGGSLIHPQW	TPSD1	61	Q9BZJ3
EWWYAHNTTEMGYIP	SH3BP4	91	Q9P0V3
AWPGNIMQHVNRYWK	ST8SIA3	276	O43173
WYQPRHNVMISTEWA	SELENBP1	191	Q13228
QYNIRSFMNVKHWPW	MYH3	816	P11055
AAYPFVNMAWEGWFL	PEX12	161	O00623
YAAAMAWAIIPHYGW	SV2A	306	Q7L0J3
AWAIIPHYGWSFQMG	SV2A	311	Q7L0J3
YVAMNFHWPFGIWLC	CMKLR2	96	P46091
AMAPAAGYHVWLWAV	GEMIN5	951	Q8TEQ6
VHSQGWFGMWIFEEY	PKHD1L1	2616	Q86WI1
WMALIPNANHINWYF	PKHD1L1	2886	Q86WI1
MNRHAWGVAWFGFAI	UPK1B	226	O75841
GWEYNQQVRHNWETM	TXNRD3	231	Q86VQ6
MHSNYEYNWRWGVVI	SLC9C2	361	Q5TAH2
PAWQWLAHVYQSQGM	TTC37	1401	Q6PGP7
FMVYPWRWGENAHNV	ZNF367	66	Q7RTV3
IFMWRQHHYQGKPTW	TRRAP	2991	Q9Y4A5
WWYAHFDGPWIARQM	MYO6	1201	Q9UM54