Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransporter activity

SLC6A3 VMP1 SLC38A2 SEC61A2 TPCN2 SLC11A2 ABCB9 TSPO2 ABCC8 SLC22A2 SLC15A5 SLC5A12 ATP1A2 SEC61A1 M6PR RYR3

3.85e-0712895716GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A3 SLC38A2 SEC61A2 TPCN2 SLC11A2 ABCB9 TSPO2 ABCC8 SLC22A2 SLC15A5 SLC5A12 ATP1A2 SEC61A1 RYR3

4.11e-0611805714GO:0022857
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A3 SLC38A2 TPCN2 SLC11A2 ABCC8 SLC5A12 ATP1A2 SEC61A1 RYR3

6.22e-06465579GO:0046873
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC6A3 SLC38A2 SLC11A2 ABCB9 ABCC8 SLC22A2 SLC15A5 SLC5A12 ATP1A2

7.64e-06477579GO:0022804
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC6A3 SLC38A2 TPCN2 SLC11A2 ABCC8 SLC5A12 ATP1A2 SEC61A1 RYR3

6.56e-05627579GO:0022890
GeneOntologyMolecularFunctionsymporter activity

SLC6A3 SLC38A2 SLC11A2 SLC15A5 SLC5A12

6.84e-05150575GO:0015293
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC6A3 SLC38A2 TSPO2 SLC22A2

9.27e-0583574GO:0015101
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC6A3 SLC38A2 TPCN2 SLC11A2 ABCC8 SLC5A12 ATP1A2 SEC61A1 RYR3

1.02e-04664579GO:0008324
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A3 SLC38A2 TPCN2 SLC5A12 ATP1A2

1.27e-04171575GO:0015081
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC6A3 SLC38A2 SLC11A2 ABCC8 SLC5A12 ATP1A2

2.12e-04301576GO:0022853
GeneOntologyMolecularFunctionprotein transporter activity

SEC61A2 SEC61A1 M6PR

2.34e-0442573GO:0140318
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A3 SLC38A2 TPCN2 SLC11A2 ABCC8 SLC5A12 ATP1A2 SEC61A1 RYR3

2.74e-04758579GO:0015318
GeneOntologyMolecularFunctionretromer complex binding

SLC11A2 M6PR

3.55e-0410572GO:1905394
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC6A3 SLC38A2 SLC11A2 SLC5A12

3.71e-04119574GO:0015294
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC6A3 SLC38A2 TPCN2 SLC11A2 ABCC8 SLC5A12 ATP1A2 SEC61A1 RYR3

3.82e-04793579GO:0015075
GeneOntologyMolecularFunctionmonoamine transmembrane transporter activity

SLC6A3 SLC22A2

5.19e-0412572GO:0008504
GeneOntologyMolecularFunctionsteroid binding

PROM1 TSPO2 SLC22A2 ATP1A2

5.65e-04133574GO:0005496
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

TPCN2 RYR3

1.19e-0318572GO:0015278
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR5P2 OR51E1 CSF2RA BRS3 PTPRO ABCC8 OR52H1 M6PR HCRTR2 ADGRL4 OR52J3

1.36e-0313535711GO:0004888
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC6A3 SLC38A2 SLC11A2 SLC15A5 SLC5A12

1.54e-03296575GO:0015291
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC6A3 SLC38A2 SLC5A12

1.61e-0381573GO:0015370
GeneOntologyMolecularFunctionneurotransmitter transmembrane transporter activity

SLC6A3 SLC22A2

1.62e-0321572GO:0005326
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC38A2 TSPO2 SLC22A2 SLC5A12

2.88e-03207574GO:0046943
GeneOntologyMolecularFunctionprotein transmembrane transporter activity

SEC61A2 SEC61A1

2.89e-0328572GO:0008320
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC38A2 TSPO2 SLC22A2 SLC5A12

2.94e-03208574GO:0005342
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC38A2 TSPO2 SLC22A2

3.36e-03105573GO:0015171
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TPCN2 RYR3

3.53e-0331572GO:0099604
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCB9 ABCC8 ATP1A2

3.74e-03109573GO:0042626
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

TPCN2 RYR3

3.99e-0333572GO:0005217
GeneOntologyMolecularFunctionmacromolecule transmembrane transporter activity

SEC61A2 SEC61A1

4.24e-0334572GO:0022884
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC38A2 SLC5A12

4.48e-0335572GO:0005343
GeneOntologyMolecularFunctioncalcium channel activity

TPCN2 SEC61A1 RYR3

5.98e-03129573GO:0005262
GeneOntologyBiologicalProcessamino acid transport

SLC6A3 SLC38A2 TSPO2 ABCC8 SLC22A2 ATP1A2

1.30e-05195556GO:0006865
GeneOntologyBiologicalProcessamino acid import across plasma membrane

SLC38A2 TSPO2 SLC22A2 ATP1A2

1.72e-0558554GO:0089718
GeneOntologyBiologicalProcessimport across plasma membrane

SLC38A2 SLC11A2 TSPO2 ABCC8 SLC22A2 ATP1A2

3.31e-05230556GO:0098739
GeneOntologyBiologicalProcesscarboxylic acid transmembrane transport

SLC38A2 TSPO2 SLC22A2 SLC5A12 ATP1A2

7.33e-05163555GO:1905039
GeneOntologyBiologicalProcessorganic acid transmembrane transport

SLC38A2 TSPO2 SLC22A2 SLC5A12 ATP1A2

8.22e-05167555GO:1903825
GeneOntologyBiologicalProcessneurotransmitter reuptake

SLC6A3 SLC22A2 ATP1A2

1.42e-0438553GO:0098810
GeneOntologyBiologicalProcessSRP-dependent cotranslational protein targeting to membrane, translocation

SEC61A2 SEC61A1

1.93e-048552GO:0006616
GeneOntologyBiologicalProcesspost-translational protein targeting to membrane, translocation

SEC61A2 SEC61A1

1.93e-048552GO:0031204
GeneOntologyBiologicalProcessL-amino acid transport

SLC38A2 ABCC8 SLC22A2 ATP1A2

1.97e-04108554GO:0015807
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC6A3 VMP1 SLC38A2 TPCN2 SLC11A2 ABCC8 SLC22A2 SLC5A12 ATP1A2 SEC61A1 RYR3

2.02e-0411575511GO:0006812
GeneOntologyBiologicalProcessnorepinephrine uptake

SLC6A3 SLC22A2

2.48e-049552GO:0051620
GeneOntologyBiologicalProcessglutamate secretion, neurotransmission

SLC38A2 ABCC8

2.48e-049552GO:0061535
GeneOntologyBiologicalProcessL-glutamate import

SLC38A2 ABCC8 ATP1A2

2.51e-0446553GO:0051938
GeneOntologyBiologicalProcessmetal ion transport

SLC6A3 VMP1 SLC38A2 TPCN2 SLC11A2 ABCC8 SLC5A12 ATP1A2 SEC61A1 RYR3

2.74e-0410005510GO:0030001
GeneOntologyBiologicalProcessamino acid transmembrane transport

SLC38A2 TSPO2 SLC22A2 ATP1A2

2.96e-04120554GO:0003333
GeneOntologyBiologicalProcessneurotransmitter uptake

SLC6A3 SLC22A2 ATP1A2

3.61e-0452553GO:0001504
GeneOntologyBiologicalProcessimport into cell

SLC6A3 SLC38A2 TPCN2 SLC11A2 PTX3 TSPO2 ABCC8 SLC22A2 ATP1A2 M6PR

4.83e-0410745510GO:0098657
GeneOntologyBiologicalProcessorganic cation transport

SLC6A3 SLC38A2 TSPO2 SLC22A2

6.05e-04145554GO:0015695
GeneOntologyBiologicalProcessneurotransmitter transport

SLC6A3 SLC38A2 ABCC8 SLC22A2 ATP1A2

6.26e-04259555GO:0006836
GeneOntologyCellularComponentSec61 translocon complex

SEC61A2 SSR4 SEC61A1

1.91e-075573GO:0005784
GeneOntologyCellularComponenttranslocon complex

SEC61A2 SSR4 SEC61A1

3.82e-076573GO:0071256
GeneOntologyCellularComponentrough endoplasmic reticulum membrane

SEC61A2 SSR4 SEC61A1

6.68e-0529573GO:0030867
GeneOntologyCellularComponentvacuolar membrane

VMP1 NPRL2 TPCN2 SLC11A2 ABCB9 TMEM9 M6PR

4.39e-04507577GO:0005774
GeneOntologyCellularComponentendoplasmic reticulum membrane

VMP1 SEC61A2 SRD5A3 ABCB9 TMEM208 TSPO2 SSR4 TUNAR RNF145 SEC61A1 RYR3

6.44e-0412935711GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

VMP1 SEC61A2 SRD5A3 ABCB9 TMEM208 TSPO2 SSR4 TUNAR RNF145 SEC61A1 RYR3

6.69e-0412995711GO:0098827
GeneOntologyCellularComponentrough endoplasmic reticulum

SEC61A2 SSR4 SEC61A1

7.12e-0464573GO:0005791
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

VMP1 SEC61A2 SRD5A3 ABCB9 TMEM208 TSPO2 SSR4 TUNAR RNF145 SEC61A1 RYR3

7.98e-0413275711GO:0042175
GeneOntologyCellularComponentlysosomal membrane

NPRL2 TPCN2 SLC11A2 ABCB9 TMEM9 M6PR

1.58e-03462576GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

NPRL2 TPCN2 SLC11A2 ABCB9 TMEM9 M6PR

1.58e-03462576GO:0098852
GeneOntologyCellularComponentsarcolemma

SLC38A2 ABCC8 ATP1A2 RYR3

1.79e-03190574GO:0042383
DomainPlug_translocon

SEC61A2 SEC61A1

8.51e-062552PF10559
DomainSecY_su_dom

SEC61A2 SEC61A1

8.51e-062552IPR023201
DomainSecY_CS

SEC61A2 SEC61A1

8.51e-062552IPR030659
DomainSecY

SEC61A2 SEC61A1

8.51e-062552PF00344
DomainSECY_1

SEC61A2 SEC61A1

8.51e-062552PS00755
DomainSECY_2

SEC61A2 SEC61A1

8.51e-062552PS00756
DomainSecY/SEC61-alpha

SEC61A2 SEC61A1

8.51e-062552IPR002208
Domain-

SEC61A2 SEC61A1

8.51e-0625521.10.3370.10
DomainTranslocon_Sec61/SecY_plug_dom

SEC61A2 SEC61A1

8.51e-062552IPR019561
DomainABC_membrane

ABCB9 ABCC8

2.25e-0324552PF00664
DomainABC_TM1F

ABCB9 ABCC8

3.06e-0328552PS50929
DomainABC1_TM_dom

ABCB9 ABCC8

3.06e-0328552IPR011527
DomainABC_transporter_CS

ABCB9 ABCC8

6.80e-0342552IPR017871
DomainCyclin-like

CASD1 CCNQ

7.12e-0343552IPR013763
DomainABC_TRANSPORTER_2

ABCB9 ABCC8

8.81e-0348552PS50893
DomainABC_tran

ABCB9 ABCC8

8.81e-0348552PF00005
DomainABC_TRANSPORTER_1

ABCB9 ABCC8

9.16e-0349552PS00211
DomainABC_transporter-like

ABCB9 ABCC8

9.53e-0350552IPR003439
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC6A3 SLC38A2 TPCN2 SLC11A2 ABCB9 SLC22A2 SLC5A12 ATP1A2 RYR3

9.64e-05681409MM14985
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC6A3 SLC38A2 TPCN2 SLC11A2 ABCB9 SLC22A2 SLC5A12 ATP1A2 RYR3

1.74e-04736409M27287
PathwayREACTOME_NEUROTRANSMITTER_CLEARANCE

SLC6A3 SLC22A2

2.17e-048402MM14500
PathwayREACTOME_NEUROTRANSMITTER_CLEARANCE

SLC6A3 SLC22A2

4.25e-0411402M26914
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC6A3 SLC38A2 SLC11A2 SLC22A2 SLC5A12

5.34e-04238405MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC6A3 SLC38A2 SLC11A2 SLC22A2 SLC5A12

6.56e-04249405M5988
Pubmed

The role of assembly in insulin's biosynthesis.

SEC61A2 SSR4 SEC61A1

8.61e-07125639631292
Pubmed

Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.

SEC61A2 SEC61A1

2.55e-06256218480044
Pubmed

Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.

M6PR TGOLN2

7.63e-06356234244781
Pubmed

The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.

SEC61A2 SEC61A1

1.52e-05456210212142
Pubmed

Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex.

SEC61A2 SEC61A1

2.54e-0555629565615
Pubmed

Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress.

SEC61A2 SEC61A1

3.80e-05656216705175
Pubmed

Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.

SLC6A3 RYR3

5.32e-05756220962236
Pubmed

ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.

TPCN2 RYR3

7.09e-05856230563862
Pubmed

KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2.

ATP1A2 SEC61A1

9.10e-05956231685809
Pubmed

IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity.

SLC6A3 SLC22A2

9.10e-05956216024787
Pubmed

Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts.

M6PR TGOLN2

1.14e-041056212388596
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

GPR180 VMP1 SLC38A2 TMEM9 CD46 SSR4 SEC61A1 M6PR TGOLN2

1.19e-04120156935696571
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

VMP1 TMEM9 CADM4 CD46 URB2 SSR4 SEC61A1 M6PR VIRMA

1.21e-04120356929180619
Pubmed

Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors.

SLC6A3 PROM1

1.66e-041256227246266
Pubmed

DNA cloning using in vitro site-specific recombination.

VMP1 PROM1 TCAIM TMEM9 SSR4 CCNQ HCRTR2

2.76e-0479456711076863
Pubmed

Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.

HDAC3 MED6

4.28e-041956216204234
Pubmed

Control of TurboID-dependent biotinylation intensity in proximity ligation screens.

VMP1 HDAC3 M6PR

5.72e-0410056336966971
Pubmed

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.

ATP1A2 TGOLN2

5.76e-042256222797923
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

SLC38A2 SLC22A2 ATP1A2

6.60e-0410556330280653
Pubmed

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer.

M6PR TGOLN2

7.46e-042556215078902
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

GPR180 SLC38A2 TMEM9 CD46 URB2 SSR4 SEC61A1

7.64e-0494256731073040
Pubmed

The LIFEdb database in 2006.

VMP1 PROM1 TCAIM TMEM9 SSR4 CCNQ

1.04e-0372056616381901
Pubmed

From ORFeome to biology: a functional genomics pipeline.

VMP1 PROM1 TCAIM TMEM9 SSR4 CCNQ

1.05e-0372256615489336
Pubmed

A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells.

PROM1 ATP1A2

1.08e-033056231065682
Pubmed

A common variant in DRD3 receptor is associated with autism spectrum disorder.

SLC6A3 APAF1 HCRTR2

1.17e-0312856319058789
InteractionCANX interactions

FSIP2 SLC38A2 POGLUT3 SLC11A2 PTPRO ADAM21 CD46 SSR4 RNF145 SEC61A1 M6PR VIRMA TMEM101 TGOLN2

1.12e-0612614914int:CANX
InteractionTVP23C interactions

TPCN2 SLC11A2 TMEM9 HCRTR2

1.03e-0556494int:TVP23C
InteractionTMEM140 interactions

SLC38A2 TMEM9 TSPO2 VIRMA

1.27e-0559494int:TMEM140
Cytoband11p15.4

OR5P2 OR51E1 OR52H1 OR52J3

1.15e-0420057411p15.4
CytobandEnsembl 112 genes in cytogenetic band chr11p15

OR5P2 OR51E1 ABCC8 OR52H1 OR52J3

6.80e-04564575chr11p15
GeneFamilySolute carriers

SLC6A3 SLC38A2 SLC11A2 SLC22A2 SLC15A5 SLC5A12

1.17e-04395366752
GeneFamilyOlfactory receptors, family 52

OR52H1 OR52J3

4.27e-0349362165
CoexpressionMILI_PSEUDOPODIA_HAPTOTAXIS_DN

SLC38A2 SEC61A2 TPCN2 SLC11A2 SRD5A3 SEC61A1 M6PR TMEM101 TGOLN2

1.30e-05681569M5314
CoexpressionMILI_PSEUDOPODIA_HAPTOTAXIS_DN

SLC38A2 SEC61A2 TPCN2 SLC11A2 SRD5A3 SEC61A1 M6PR TMEM101 TGOLN2

1.68e-05703569MM1055
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Mesenchymal-Unfolded_protein_responsible_cell|10w / Sample Type, Dataset, Time_group, and Cell type.

VMP1 NPRL2 TMEM208 SSR4 SEC61A1 M6PR

2.15e-07200576bc479baca21f0ff19a1c4efdb9530f289a1ab115
ToppCellILEUM-non-inflamed-(5)_Plasmablasts|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ABCB9 TMEM208 DEPDC1 SSR4 SEC61A1

3.34e-0617957558c8996120637315dcbd1991a71516c09173051e
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ABCB9 TMEM208 DEPDC1 SSR4 SEC61A1

4.94e-06194575ffba703f61faaac8b4b9a5e46cd335214303de7b
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ABCB9 TMEM208 DEPDC1 SSR4 SEC61A1

5.32e-061975756fe013f98c64b3c5a4e61002254717fb411f8e59
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Myeloid-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPCN2 CSF2RA CD46 DEPDC1

5.51e-05162574b502d6af6868425b5c919740e011330c0d3cf3b8
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PROM1 ABCC8 APAF1 DEPDC1

6.80e-05171574913bae728b5e653771a27c79a309eb023699f1d0
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PROM1 ABCC8 APAF1 DEPDC1

6.80e-05171574f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCelldroplet-Spleen-nan-3m-Myeloid-macrophage|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTCHD1 CSF2RA PTPRO RYR3

6.80e-051715745b74df72e36ad04dfb25c72f1ca8efe043f6cda6
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B_plasma-Plasma_cells|lymph-node_spleen / Manually curated celltypes from each tissue

ABCB9 TMEM208 SSR4 SEC61A1

8.84e-05183574a6866951866373a1029e04818f4a4a31278c409d
ToppCellILEUM-inflamed-(5)_IgA_plasma_cells|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ABCB9 TMEM208 SSR4 SEC61A1

8.84e-05183574a113558ca4220bac31f9336033dff82a618d9258
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B_plasma|lymph-node_spleen / Manually curated celltypes from each tissue

ABCB9 TMEM208 SSR4 SEC61A1

8.84e-05183574beadc69f511cf183e493cb445135f0748ab8b20e
ToppCellmetastatic_Lymph_Node-B_lymphocytes-MALT_B_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

ABCB9 TMEM208 SSR4 SEC61A1

9.22e-05185574bb87fa174f80706fe7be60d3b9fc3e2a6b373038
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PROM1 SRD5A3 SSR4 RNF145

9.41e-0518657455fe25f4d0f2bc0fd4802a0a375169f2c41472fc
ToppCellILEUM-inflamed-(5)_Plasma|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ABCB9 TMEM208 SSR4 SEC61A1

9.41e-051865744d105437487bf04f8cd6129b822d5c060af0bee8
ToppCellnormal_Pleural_Fluid-B_lymphocytes-MALT_B_cells|normal_Pleural_Fluid / Location, Cell class and cell subclass

ABCB9 TMEM208 SSR4 SEC61A1

1.00e-0418957405e8fb483ebb9010cc54b39d78cca960c58c0f01
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-plasma_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ABCB9 TMEM208 SSR4 SEC61A1

1.02e-0419057476b747bafff09bf8375a5717c9f213cbfb405bac
ToppCellmetastatic_Lymph_Node-B_lymphocytes-MALT_B_cells|B_lymphocytes / Location, Cell class and cell subclass

ABCB9 TMEM208 SSR4 SEC61A1

1.02e-041905745ec49cc7692053c1a525ca9137c996ccd2794e1c
ToppCellwk_08-11-Epithelial-PNS-Early_Schwann|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

TPCN2 CASD1 CADM4 ATP1A2

1.02e-041905748190674a48607984726974765aafbca116f437e0
ToppCellsevere-Lymphocytic-Plasmablast|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

ABCB9 TMEM208 SSR4 SEC61A1

1.04e-0419157473660d762c9d451980c21adc426db6670bcaf37f
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-B_lymphocytic-plasma_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ABCB9 TMEM208 SSR4 SEC61A1

1.04e-041915747b4b5d90d1023d03239ed986f273afa734d3124d
ToppCellPBMC-Convalescent-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ABCB9 TMEM208 SSR4 SEC61A1

1.04e-04191574dd1d38a531a272a746c16807688013d29cab823a
ToppCellremission-Plasmablast|remission / disease stage, cell group and cell class

ABCB9 TMEM208 SSR4 SEC61A1

1.06e-041925744bcf22061905177ad8625b87be2fbca9bff03ec6
ToppCellPBMC-Convalescent-Lymphocyte-B-Plasmablast-Plasmablast-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ABCB9 TMEM208 SSR4 SEC61A1

1.09e-04193574902dea0bf6c2997d8b877ae01113460e511a364a
ToppCellPBMC-Convalescent-Lymphocyte-B-Plasmablast|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ABCB9 TMEM208 SSR4 SEC61A1

1.09e-04193574239f2ac64f63d4d65997ba83b932a1fab1909efb
ToppCellPBMC-Convalescent-Lymphocyte-B-Plasmablast-Plasmablast|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ABCB9 TMEM208 SSR4 SEC61A1

1.09e-041935742790b245d6052063c207087b91fb9375a0e8055d
ToppCellremission-Plasmablast|World / disease stage, cell group and cell class

ABCB9 TMEM208 SSR4 SEC61A1

1.09e-04193574d62617c72863642f2222f7ed28bc6b90ee09b4e0
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ABCB9 TMEM208 SSR4 SEC61A1

1.09e-0419357422684aa2a368211baba79d29379d0bc442830524
ToppCellPBMC-Convalescent-Lymphocyte-B-Plasmablast-Plasmablast|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

ABCB9 TMEM208 SSR4 SEC61A1

1.09e-0419357494daa8a5d23558998fe3bff585344e22ce679f2d
ToppCellPBMC-Convalescent-Lymphocyte-B-Plasmablast|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

ABCB9 TMEM208 SSR4 SEC61A1

1.09e-0419357433dad901e0597f0057edc2bfbd64fd81f298b94e
ToppCellB_cell_maturation-plasma|B_cell_maturation / Lineage and Cell class

ABCB9 TMEM208 SSR4 SEC61A1

1.09e-041935745415f7e54bc40aec3dbe27fd97f6e9be6db08a48
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PROM1 SRD5A3 SSR4 RNF145

1.11e-04194574855d6acfcf323868ba98b213f06186ad4793d4ed
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PROM1 SRD5A3 SSR4 RNF145

1.11e-04194574dc531cf9089f2c956621d70d49a2b8219b4b45c1
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PROM1 SRD5A3 SSR4 RNF145

1.11e-0419457429a7770bdbea6081a9ed64a997cd92a1cbf4af58
ToppCell(5)_Plasma_IgM|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ABCB9 TMEM208 SSR4 SEC61A1

1.11e-0419457447c0f7a1c39ba0836e40ea3ca8066457c0951575
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PROM1 SRD5A3 SSR4 RNF145

1.11e-04194574ca051088f880154ae2fd3f0ab3cef5a8dba8c371
ToppCellCOVID-19_Convalescent-Lymphoid_P|COVID-19_Convalescent / Disease group, lineage and cell class

ABCB9 TMEM208 SSR4 SEC61A1

1.13e-041955744fff177aa4617060b594e637885cd0c91e7d6609
ToppCellCOVID-19_Convalescent-Lymphoid_P-Plasmablast|COVID-19_Convalescent / Disease group, lineage and cell class

ABCB9 TMEM208 SSR4 SEC61A1

1.13e-04195574b4cfc31e4f7e899c6b2578b1ea4fbf609b7ae914
ToppCellsevere-Plasmablast|severe / disease stage, cell group and cell class

ABCB9 TMEM208 SSR4 SEC61A1

1.13e-04195574e11616ad568e50e4c720b50b0c071f484c31d16b
ToppCellMild/Remission-Plasmablast|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ABCB9 TMEM208 SSR4 SEC61A1

1.13e-0419557452bdd609253613b7db75dccbc1c01c05e8d73f79
ToppCellnormal_Pleural_Fluid-B_lymphocytes-MALT_B_cells|B_lymphocytes / Location, Cell class and cell subclass

ABCB9 TMEM208 SSR4 SEC61A1

1.15e-041965740ff8cfb209063a8b217df6690ac1dec89004593f
ToppCellSevere-Plasmablast|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ABCB9 TMEM208 SSR4 SEC61A1

1.15e-04196574ee991f1d9936c656f4fbc2e0cec9e0166a34bc5b
ToppCelltumor_Lung-B_lymphocytes-MALT_B_cells|B_lymphocytes / Location, Cell class and cell subclass

ABCB9 TMEM208 SSR4 SEC61A1

1.15e-041965741f63dba9d226e4a42d9bee7258580a1e547c0e92
ToppCell(2)_B_cells-(2)_Plasma_cells|(2)_B_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

ABCB9 TMEM208 SSR4 SEC61A1

1.15e-04196574cc4f59b885d58e43471e85c51d8e366e68d10846
ToppCellMild/Remission-Plasmablast|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ABCB9 TMEM208 SSR4 SEC61A1

1.15e-04196574dcf0a804a79a05454658498d1f87320c7e079219
ToppCellSevere-Plasmablast|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ABCB9 TMEM208 SSR4 SEC61A1

1.17e-041975741089aa7991812378668d0f3d57f8000e6245a713
ToppCell(5)_Plasma|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ABCB9 TMEM208 SSR4 SEC61A1

1.17e-04197574ebb15b018ee8a68e917b43e59a5fc4330d62de21
ToppCellTransverse-B_cell|Transverse / Region, Cell class and subclass

ABCB9 TMEM208 SSR4 SEC61A1

1.22e-0419957491ac70fe1f351eb7ee3600a17120cd1301220041
ToppCellCaecum-B_cell|Caecum / Region, Cell class and subclass

ABCB9 TMEM208 SSR4 SEC61A1

1.22e-041995743e4d0206a65643ab12000d7e3af7ddeb2a5f2b62
ToppCellTransverse-(2)_B_cell|Transverse / shred on region, Cell_type, and subtype

ABCB9 TMEM208 SSR4 SEC61A1

1.22e-04199574fcdea790d2b34efac8ce80a296db54916ab621cb
ToppCellTransverse-(2)_B_cell-(20)_B_cell_IgA_Plasma|Transverse / shred on region, Cell_type, and subtype

ABCB9 TMEM208 SSR4 SEC61A1

1.22e-041995748caaa08b046f766af298d03961ccac6e4569e2a6
ToppCellCOVID-19-COVID-19_Convalescent-Lymphocyte-B-Plasmablast|COVID-19_Convalescent / Disease, condition lineage and cell class

ABCB9 TMEM208 SSR4 SEC61A1

1.22e-041995747bd4a07c4d0843921a99d5c6df6eb55e62f1ba0e
ToppCellCaecum-(2)_B_cell|Caecum / shred on region, Cell_type, and subtype

ABCB9 TMEM208 SSR4 SEC61A1

1.22e-0419957499c44abd101f9e294468b006a6b7c88c7e6dd020
ToppCellCaecum-(2)_B_cell-(20)_B_cell_IgA_Plasma|Caecum / shred on region, Cell_type, and subtype

ABCB9 TMEM208 SSR4 SEC61A1

1.22e-0419957476b3c2ee5da8ddc214e5919b5804dfedcbb60d30
ToppCellCaecum-B_cell-B_cell_IgA_Plasma|Caecum / Region, Cell class and subclass

ABCB9 TMEM208 SSR4 SEC61A1

1.22e-0419957449c19601566205f41f04bfb5714f865398482d39
ToppCellTransverse-B_cell-B_cell_IgA_Plasma|Transverse / Region, Cell class and subclass

ABCB9 TMEM208 SSR4 SEC61A1

1.22e-04199574ea65cadaf464ff4c1040fceb5f3724706f8447c1
ToppCellInfluenza-Influenza_Severe-Myeloid-cDC|Influenza_Severe / Disease, condition lineage and cell class

SEC61A2 HDAC3 PPM1J RYR3

1.24e-04200574b8415a68ad6f4fea562236a1b0da0dc376d874fb
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_2-SCUBE1|Neuronal / cells hierarchy compared to all cells using T-Statistic

CSF2RA SLC15A5 HCRTR2 RYR3

1.24e-04200574012dd2180f6f596d6e55e864be2e62b53c15edb2
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Mesenchymal|10w / Sample Type, Dataset, Time_group, and Cell type.

NPRL2 TMEM208 SSR4 SEC61A1

1.24e-04200574c968d077b7fd24fb06cedb51c737996f25667eb7
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_2-SCUBE1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

CSF2RA SLC15A5 HCRTR2 RYR3

1.24e-0420057406f949c81eecba00203f0716d0c5854724871184
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_2|Neuronal / cells hierarchy compared to all cells using T-Statistic

CSF2RA SLC15A5 HCRTR2 RYR3

1.24e-04200574d31e26387d879ee30731c497cea6aaf4746e40d9
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_2-SCUBE1--L6|Neuronal / cells hierarchy compared to all cells using T-Statistic

CSF2RA SLC15A5 HCRTR2 RYR3

1.24e-0420057457e8aea2c2f736ce37940dceb36224552dc33da1
ToppCell(20)_B_cell_IgA_Plasma|World / shred on Cell_type and subtype

ABCB9 TMEM208 SSR4 SEC61A1

1.34e-04204574fcca2135876031644a81d4aa3bc04145558f7745
ComputationalNeighborhood of MDM2

ABCB9 CADM4 ABCC8 HCRTR2 RYR3

5.74e-04279275MORF_MDM2
ComputationalNeighborhood of NOS2A

ABCB9 CADM4 ABCC8 HCRTR2 RYR3

6.63e-04288275MORF_NOS2A
ComputationalNeighborhood of ARL3

ABCB9 CADM4 ABCC8 HCRTR2 RYR3

8.47e-04304275MORF_ARL3
ComputationalNeighborhood of ERCC4

ABCB9 CADM4 ABCC8 HCRTR2 RYR3

1.08e-03321275MORF_ERCC4
ComputationalNeighborhood of BCL2L11

CADM4 ABCC8 HCRTR2 RYR3

1.12e-03186274MORF_BCL2L11
Diseaseattention deficit hyperactivity disorder (implicated_via_orthology)

SLC6A3 PTCHD1 ADGRL4

1.64e-0528523DOID:1094 (implicated_via_orthology)
Diseaseprostate carcinoma, type 2 diabetes mellitus

SEC61A2 TPCN2 SLC22A2

1.57e-0459523EFO_0001663, MONDO_0005148
DiseaseQRS duration

SLC38A2 PROM1 CES5A OR52H1 SMIM44

1.79e-04298525EFO_0005055
DiseaseMajor Depressive Disorder

PROM1 PTX3 APAF1 M6PR

8.91e-04243524C1269683
DiseaseUnipolar Depression

PROM1 PTX3 APAF1 M6PR

1.13e-03259524C0041696
DiseaseParkinsonism (biomarker_via_orthology)

SLC6A3 ABCC8

1.65e-0334522DOID:0080855 (biomarker_via_orthology)
Diseaseparental longevity

ABCC8 SLC22A2 CD46 RYR3 ADGRL4

1.75e-03494525EFO_0007796

Protein segments in the cluster

PeptideGeneStartEntry
VALYQGVYSQILLEL

URB2

1151

Q14146
EGIHLYLIVVGVIYN

ADGRL4

511

Q9HBW9
TYVTVDNLGILYILQ

APAF1

1231

O14727
YKQLGTYIILIGIEI

ADAM21

246

Q9UKJ8
IAVAVLYLALQVYGV

CCNQ

191

Q8N1B3
VGVAVICVVPYRYLQ

CD46

356

P15529
LVAYIEEAINAILGY

FSIP2

901

Q5CZC0
LYLIAVLGNLTIIYI

OR51E1

36

Q8TCB6
ALAAYEDVLVVVVQY

CES5A

161

Q6NT32
YELFVNILVVCGYIT

DEPDC1

296

Q5TB30
ALYVVAAVVSVAYLG

SLC11A2

506

P49281
LLVLVYFVIACIYAQ

GPR180

176

Q86V85
YVNDIVIGILELLKY

HDAC3

146

O15379
LYYIITLVVVNGNVV

PTPRO

91

Q16827
LLVVYIAGFLIAVSY

OR5P2

141

Q8WZ92
GLVYYVLVGLTVLSQ

SRD5A3

166

Q9H8P0
YIIVFVVALIGNVLV

HCRTR2

61

O43614
DNLYLGVVLAAVVIV

ATP1A2

126

P50993
IIYILVLGVFYNENT

CASD1

406

Q96PB1
RALYVLVVYDPGAVV

CADM4

301

Q8NFZ8
FYLILQYVLLGVAET

SLC15A5

431

A6NIM6
YQVAYTVGLLVLAGV

SLC22A2

241

O15244
NLGSVYIYVLLIVGT

CSF2RA

321

P15509
QVIPLADYYIIAGVI

MED6

91

O75586
IQLYLSYQSIVFVVG

PTX3

236

P26022
IIYIVAVVGNCILLY

OR52H1

41

Q8NGJ2
NLVLIGISYVYILRA

OR52J3

211

Q8NH60
QISYLLGGIQVVYIE

TCAIM

316

Q8N3R3
GILLAVTIIYQYFEI

SEC61A2

446

Q9H9S3
VAILQSYLCYIVGLI

PTCHD1

796

Q96NR3
VILGLKIVYYEAGII

PROM1

96

O43490
CALVVIYLLGKVYVA

PPM1J

261

Q5JR12
RIAIQNLLYYGVVTL

NPRL2

221

Q8WTW4
NLLYYGVVTLVSILQ

NPRL2

226

Q8WTW4
LVVQVSILYYGGHLV

ABCB9

421

Q9NP78
IVGVILLYYILGVSA

ABCC8

446

Q09428
YITYAVIISVGILGN

BRS3

51

P32247
GVVTVQYSDIGLLYI

TECTA

821

O75443
AAVVLPVRYFYLQAV

POGLUT3

41

Q7Z4H8
FAYLVTAAILVAVLY

TGOLN2

386

O43493
IIVIYLSVVGALLLY

TMEM9

91

Q9P0T7
GTILNLIVIIFVYIY

TUNAR

31

A0A1B0GTB2
AVYVVGGFLYQRLVV

M6PR

201

P20645
GILLAVTIIYQYFEI

SEC61A1

446

P61619
VLAAAIGLVIYYLAF

SSR4

151

P51571
YLNGNYLVLLVSLVV

SLC38A2

191

Q96QD8
LLAVVVYLYTVVAFN

RYR3

4676

Q15413
ILISLYVGFFYNVII

SLC6A3

146

Q01959
YVLYLLLAALVVVAV

SMIM44

36

A0A286YF18
ASQVLYLTEVVYALL

USP9Y

1086

O00507
YLRIILGANAIYCLV

TMEM208

26

Q9BTX3
LLLVQTAIYSVVGYA

TSPO2

46

Q5TGU0
ILYTGVVVYAPALAL

SLC5A12

136

Q1EHB4
AYRELVQVVEVYGLL

RNF145

201

Q96MT1
VAYNYACILILVVVQ

VIRMA

846

Q69YN4
LVVVYYVFAIIGINL

TPCN2

586

Q8NHX9
SGYYVTLAAQILAVL

TMEM101

196

Q96IK0
LAVLIATYYVEGVHQ

VMP1

86

Q96GC9