Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpolypeptide N-acetylgalactosaminyltransferase activity

GALNTL6 GALNT2 GALNT12 GALNT4

5.58e-06201204GO:0004653
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1C CACNA1D ANO1 CATSPER1 KCNC1 KCNC3 KCNN2 KCNN3

1.44e-051821208GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1C CACNA1D ANO1 CATSPER1 KCNC1 KCNC3 KCNN2 KCNN3

1.56e-051841208GO:0022832
GeneOntologyMolecularFunctioncalcium-activated cation channel activity

ANO1 CATSPER1 KCNN2 KCNN3

1.96e-05271204GO:0005227
GeneOntologyMolecularFunctioncytoskeletal protein binding

CACNA1C CACNA1D RANBP10 SYNM SPTBN2 OPA1 GSN NOD2 CEP350 SPTBN5 KIF9 EFHC1 KCNC1 CLU SIPA1L1 FHOD1 KCNN2 MACF1 MYO18B

2.96e-05109912019GO:0008092
GeneOntologyMolecularFunctionmonoatomic ion-gated channel activity

ANO1 CATSPER1 KCNN2 KCNN3

3.44e-05311204GO:0022839
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1C CACNA1D CATSPER1 KCNC1 KCNC3 KCNN2 KCNN3

3.74e-051521207GO:0022843
GeneOntologyMolecularFunctionacetylgalactosaminyltransferase activity

GALNTL6 GALNT2 GALNT12 GALNT4

5.62e-05351204GO:0008376
GeneOntologyMolecularFunctionsmall conductance calcium-activated potassium channel activity

KCNN2 KCNN3

2.13e-0441202GO:0016286
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1C CACNA1D ANO1 CATSPER1 KCNC1 KCNC3 PKD1 KCNN2 KCNN3

2.30e-043431209GO:0005261
GeneOntologyMolecularFunctionhexosyltransferase activity

GALNTL6 GALNT2 UGT1A8 GALNT12 COLGALT1 FUT1 GALNT4

2.89e-042111207GO:0016758
GeneOntologyMolecularFunctionUDP-glycosyltransferase activity

GALNTL6 GALNT2 UGT1A8 GALNT12 COLGALT1 GALNT4

3.27e-041531206GO:0008194
GeneOntologyMolecularFunctionglycosyltransferase activity

GALNTL6 GALNT2 UGT1A8 GALNT12 COLGALT1 UMPS FUT1 GALNT4

3.54e-042881208GO:0016757
GeneOntologyMolecularFunctionserine C-palmitoyltransferase activity

SPTLC3 SPTLC2

3.54e-0451202GO:0004758
GeneOntologyMolecularFunctionC-palmitoyltransferase activity

SPTLC3 SPTLC2

3.54e-0451202GO:0016454
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in cardiac muscle cell action potential

CACNA1C CACNA1D

3.54e-0451202GO:0086007
GeneOntologyMolecularFunctionactin filament binding

SPTBN2 GSN SPTBN5 SIPA1L1 FHOD1 MACF1 MYO18B

4.49e-042271207GO:0051015
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1C CACNA1D ANO1 SLC26A9 CATSPER1 KCNC1 KCNC3 PKD1 KCNN2 KCNN3

4.56e-0445912010GO:0005216
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

ABCA1 SMARCA5 ABCA4 LSG1 RGS19 ARHGAP35 OPA1 KIF9 ATP6V1H CLU TSR1 MACF1 MTREX

7.85e-0477512013GO:0017111
GeneOntologyMolecularFunctionalpha-actinin binding

CACNA1C CACNA1D KCNN2

8.41e-04311203GO:0051393
GeneOntologyMolecularFunctiongated channel activity

CACNA1C CACNA1D ANO1 CATSPER1 KCNC1 KCNC3 KCNN2 KCNN3

9.34e-043341208GO:0022836
GeneOntologyMolecularFunctionchannel activity

CACNA1C CACNA1D ANO1 SLC26A9 CATSPER1 KCNC1 KCNC3 PKD1 KCNN2 KCNN3

1.27e-0352512010GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1C CACNA1D ANO1 SLC26A9 CATSPER1 KCNC1 KCNC3 PKD1 KCNN2 KCNN3

1.29e-0352612010GO:0022803
GeneOntologyMolecularFunctionpalmitoyltransferase activity

SPTLC3 SPTLC2 CPT2

1.42e-03371203GO:0016409
GeneOntologyMolecularFunctionpyrophosphatase activity

ABCA1 SMARCA5 ABCA4 LSG1 RGS19 ARHGAP35 OPA1 KIF9 ATP6V1H CLU TSR1 MACF1 MTREX

1.61e-0383912013GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

ABCA1 SMARCA5 ABCA4 LSG1 RGS19 ARHGAP35 OPA1 KIF9 ATP6V1H CLU TSR1 MACF1 MTREX

1.63e-0384012013GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ABCA1 SMARCA5 ABCA4 LSG1 RGS19 ARHGAP35 OPA1 KIF9 ATP6V1H CLU TSR1 MACF1 MTREX

1.63e-0384012013GO:0016818
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1C CACNA1D ANO1 SLC26A9 NDUFS3 ATP6V1H CATSPER1 KCNC1 KCNC3 PKD1 KCNN2 KCNN3

2.04e-0375812012GO:0015318
GeneOntologyMolecularFunctionactinin binding

CACNA1C CACNA1D KCNN2

2.19e-03431203GO:0042805
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1C CACNA1D ANO1 NDUFS3 ATP6V1H CATSPER1 KCNC1 KCNC3 PKD1 KCNN2 KCNN3

2.21e-0366412011GO:0008324
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1C CACNA1D CATSPER1

2.66e-03461203GO:0005245
GeneOntologyMolecularFunctioncarbohydrate binding

GALNTL6 ATRN GALNT2 LGALS16 GALNT12 PKD1 GALNT4

2.71e-033101207GO:0030246
GeneOntologyMolecularFunctionphosphoric diester hydrolase activity

PDE8A PDE9A PLCD4 PLCL2

2.80e-03971204GO:0008081
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1C CACNA1D ANO1 SLC26A9 NDUFS3 ATP6V1H CATSPER1 KCNC1 KCNC3 PKD1 KCNN2 KCNN3

2.95e-0379312012GO:0015075
GeneOntologyMolecularFunctioncalcium-activated potassium channel activity

KCNN2 KCNN3

3.11e-03141202GO:0015269
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1C CACNA1D

3.11e-03141202GO:0008331
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNC1 KCNC3 KCNN2 KCNN3

3.35e-031021204GO:0005249
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ABCA1 ABCA4 ANO1

3.57e-03511203GO:0140303
GeneOntologyCellularComponentcalcium channel complex

CACNA1C CACNA1D CATSPERD CATSPER1 PKD1

6.06e-05731195GO:0034704
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1C CACNA1D CATSPERD CATSPER1

1.35e-04461194GO:0005891
GeneOntologyCellularComponentcation channel complex

CACNA1C CACNA1D CATSPERD CATSPER1 KCNC1 KCNC3 PKD1

4.00e-042351197GO:0034703
GeneOntologyCellularComponenttransmembrane transporter complex

CACNA1C CACNA1D CATSPERD ANO1 NDUFS3 ATP6V1H CATSPER1 KCNC1 KCNC3 PKD1

8.21e-0452311910GO:1902495
GeneOntologyCellularComponentserine palmitoyltransferase complex

SPTLC3 SPTLC2

8.80e-0481192GO:0017059
GeneOntologyCellularComponentpresynaptic membrane

CACNA1C CACNA1D ANO1 KCNC1 KCNC3 GPR158 CTBP1

1.05e-032771197GO:0042734
GeneOntologyCellularComponentspectrin

SPTBN2 SPTBN5

1.13e-0391192GO:0008091
GeneOntologyCellularComponenttransporter complex

CACNA1C CACNA1D CATSPERD ANO1 NDUFS3 ATP6V1H CATSPER1 KCNC1 KCNC3 PKD1

1.20e-0355011910GO:1990351
GeneOntologyCellularComponentleading edge membrane

CACNA1D PDE9A KCNC1 KCNC3 PLEKHA1 MACF1

1.30e-032101196GO:0031256
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA1C CACNA1D CATSPERD ANO1 CATSPER1 KCNC1 KCNC3 PKD1

1.46e-033781198GO:0034702
GeneOntologyCellularComponentpodosome

GSN KIF9 TNS3

1.64e-03411193GO:0002102
GeneOntologyCellularComponentactin cytoskeleton

SPTBN2 ARHGAP35 GSN SPTBN5 KIF9 SIPA1L1 FHOD1 MACF1 MYO18B TNS3

1.69e-0357611910GO:0015629
GeneOntologyCellularComponentpalmitoyltransferase complex

SPTLC3 SPTLC2

1.71e-03111192GO:0002178
GeneOntologyCellularComponentZ disc

CACNA1C CACNA1D SYNM KCNN2 MYO18B

1.74e-031511195GO:0030018
DomainRicin_B_lectin

GALNTL6 GALNT2 GALNT12 GALNT4

1.73e-05251184PF00652
DomainRICIN

GALNTL6 GALNT2 GALNT12 GALNT4

2.76e-05281184SM00458
DomainRICIN_B_LECTIN

GALNTL6 GALNT2 GALNT12 GALNT4

2.76e-05281184PS50231
DomainChannel_four-helix_dom

CACNA1C CACNA1D CATSPER1 KCNC1 KCNC3

2.98e-05571185IPR027359
Domain-

CACNA1C CACNA1D CATSPER1 KCNC1 KCNC3

2.98e-055711851.20.120.350
DomainRicin_B_lectin

GALNTL6 GALNT2 GALNT12 GALNT4

3.65e-05301184IPR000772
DomainGlycos_transf_2

GALNTL6 GALNT2 GALNT12 GALNT4

3.65e-05301184PF00535
DomainGlyco_trans_2-like

GALNTL6 GALNT2 GALNT12 GALNT4

3.65e-05301184IPR001173
DomainDUF1126

EFHC1 NME7

1.18e-0431182IPR010554
DomainCAC1F_C

CACNA1C CACNA1D

1.18e-0431182IPR031688
DomainDUF1126

EFHC1 NME7

1.18e-0431182PF06565
DomainDM10

EFHC1 NME7

1.18e-0431182SM00676
DomainDM10

EFHC1 NME7

1.18e-0431182PS51336
DomainCAC1F_C

CACNA1C CACNA1D

1.18e-0431182PF16885
DomainUncharacterised_DM10

EFHC1 NME7

1.18e-0431182IPR006602
DomainCaMBD

KCNN2 KCNN3

2.36e-0441182PF02888
DomainCaM-bd_dom

KCNN2 KCNN3

2.36e-0441182IPR004178
DomainCaMBD

KCNN2 KCNN3

2.36e-0441182SM01053
DomainVDCC_L_a1su

CACNA1C CACNA1D

2.36e-0441182IPR005446
DomainK_chnl_Ca-activ_SK

KCNN2 KCNN3

2.36e-0441182IPR015449
DomainK_chnl_volt-dep_Kv3

KCNC1 KCNC3

2.36e-0441182IPR003974
DomainSK_channel

KCNN2 KCNN3

2.36e-0441182PF03530
DomainSpectrin

SPTBN2 SPTBN5 MACF1

3.97e-04231183PF00435
DomainACTININ_2

SPTBN2 SPTBN5 MACF1

3.97e-04231183PS00020
DomainACTININ_1

SPTBN2 SPTBN5 MACF1

3.97e-04231183PS00019
DomainActinin_actin-bd_CS

SPTBN2 SPTBN5 MACF1

3.97e-04231183IPR001589
DomainAA_TRANSFER_CLASS_2

SPTLC3 SPTLC2

5.84e-0461182PS00599
DomainAminotrans_II_pyridoxalP_BS

SPTLC3 SPTLC2

5.84e-0461182IPR001917
DomainIon_trans_dom

CACNA1C CACNA1D CATSPER1 KCNC1 KCNC3

7.84e-041141185IPR005821
DomainIon_trans

CACNA1C CACNA1D CATSPER1 KCNC1 KCNC3

7.84e-041141185PF00520
DomainSpectrin_repeat

SPTBN2 SPTBN5 MACF1

7.97e-04291183IPR002017
DomainCa_chan_IQ

CACNA1C CACNA1D

8.14e-0471182SM01062
DomainCa_chan_IQ

CACNA1C CACNA1D

8.14e-0471182PF08763
DomainVDCC_a1su_IQ

CACNA1C CACNA1D

8.14e-0471182IPR014873
DomainGPHH

CACNA1C CACNA1D

8.14e-0471182PF16905
DomainGPHH_dom

CACNA1C CACNA1D

8.14e-0471182IPR031649
DomainSPEC

SPTBN2 SPTBN5 MACF1

1.07e-03321183SM00150
DomainSpectrin/alpha-actinin

SPTBN2 SPTBN5 MACF1

1.07e-03321183IPR018159
DomainPH_dom-spectrin-type

SPTBN2 SPTBN5

1.38e-0391182IPR001605
DomainPH_dom-like

ARHGAP23 SPTBN2 PLCD4 SPTBN5 JAK2 PLCL2 PLEKHA1 PLEKHA7 TNS3

1.54e-034261189IPR011993
DomainVDCCAlpha1

CACNA1C CACNA1D

1.72e-03101182IPR002077
Domain-

GALNTL6 GALNT2 GALNT12 COLGALT1

1.73e-038111843.90.550.10
DomainPH

ARHGAP23 SPTBN2 PLCD4 SPTBN5 PLCL2 PLEKHA1 PLEKHA7

1.94e-032781187SM00233
DomainPH_DOMAIN

ARHGAP23 SPTBN2 PLCD4 SPTBN5 PLCL2 PLEKHA1 PLEKHA7

1.98e-032791187PS50003
DomainPH_domain

ARHGAP23 SPTBN2 PLCD4 SPTBN5 PLCL2 PLEKHA1 PLEKHA7

2.02e-032801187IPR001849
DomainNucleotide-diphossugar_trans

GALNTL6 GALNT2 GALNT12 COLGALT1

2.35e-03881184IPR029044
DomainABC_A

ABCA1 ABCA4

2.51e-03121182IPR026082
Domain-

ARHGAP23 SPTBN2 PLCD4 SPTBN5 PLCL2 PLEKHA1 PLEKHA7 TNS3

3.40e-0339111882.30.29.30
DomainEF-hand_like

PLCD4 PLCL2

3.94e-03151182PF09279
DomainPI-PLC-Y

PLCD4 PLCL2

3.94e-03151182PF00387
DomainPLCYc

PLCD4 PLCL2

3.94e-03151182SM00149
DomainPLipase_C_Pinositol-sp_Y

PLCD4 PLCL2

3.94e-03151182IPR001711
DomainPIPLC_Y_DOMAIN

PLCD4 PLCL2

3.94e-03151182PS50008
DomainPI-PLC_fam

PLCD4 PLCL2

3.94e-03151182IPR001192
DomainPLC_EF-hand-like

PLCD4 PLCL2

3.94e-03151182IPR015359
DomainAminotran_1_2

SPTLC3 SPTLC2

5.06e-03171182PF00155
DomainAminotransferase_I/II

SPTLC3 SPTLC2

5.06e-03171182IPR004839
DomainPI-PLC-X

PLCD4 PLCL2

5.67e-03181182PF00388
DomainPLCXc

PLCD4 PLCL2

5.67e-03181182SM00148
DomainPDEase

PDE8A PDE9A

6.31e-03191182IPR023088
DomainPIPLC_X_DOMAIN

PLCD4 PLCL2

6.31e-03191182PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCD4 PLCL2

6.31e-03191182IPR000909
Pubmed

Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2.

CACNA1C CACNA1D KCNN2

1.60e-074120317110593
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DOCK1 CACNA1C ATRN SPTLC3 DEPTOR GALNT2 PDE9A ARHGAP35 INTS8 NDUFS3 ZNF331 JAK2 TECPR2 GPR158 NT5C2 KCNN2 MACF1 CTBP1 IFT122 IGSF9B

1.86e-0714891202028611215
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

CUL2 RANBP10 PDE8A PDE9A NUP107 WEE1 OPA1 GSN ZNF836 EFHC1 MAGED2 SCD SIPA1L1 PLCL2 CTBP1 IFT122 NME7 PLEKHA7

6.69e-0713211201827173435
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ATRN GALNT2 PDE9A SYNM RBL2 SPTBN2 DEF8 INTS8 ZNF331 CEP350 ZNF836 CLU SIPA1L1 PKD1 MACF1 CTBP1 IFT122

2.10e-0612851201735914814
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

RANBP10 TMEM248 AFF2 PDE8A ARV1 RBL2 PKHD1L1 JAK2 MAGED2 PKD1 C5 NME7

4.78e-066861201229987050
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RANBP10 LSG1 SPTBN2 OPA1 GSN STRIP1 WDR91 MAGED2 CLU GPR158 SIPA1L1 NT5C2 MACF1 CTBP1

6.26e-069631201428671696
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

RANBP10 SPTBN2 SIPA1L1 PLCL2 SCAPER MACF1

6.26e-06130120612421765
Pubmed

Ion channel expression in the developing enteric nervous system.

CACNA1C KCNC1 KCNN2 KCNN3

8.15e-0637120425798587
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

LSG1 ARHGAP35 CEP350 MAGED2 SIPA1L1 MACF1 TNS3

8.57e-06209120736779422
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RANBP10 ARHGAP23 SYNM SPTLC2 SPTBN2 ARHGAP35 CEP350 ZNF836 SCAPER MACF1

8.64e-064931201015368895
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1C CACNA1D KCNC1 KCNC3 KCNN2 KCNN3

9.19e-06139120616985003
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

CUL2 SMARCA5 NUP107 SPTBN2 ARHGAP35 STRIP1 MAGED2 MACF1 CTBP1 PSPC1

9.43e-064981201036634849
Pubmed

O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components.

GALNT2 LAMA5 GALNT12 GALNT4

1.12e-0540120422643896
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

ATRN PDE8A RBL2 CLTRN LAMA5 NCCRP1 GSN STRIP1 ATP6V1H CLU PKD1 PLEKHA1 C5 PLEKHA7

1.14e-0510161201419056867
Pubmed

Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.

KCNC1 KCNC3

1.18e-052120233508244
Pubmed

LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1.

ABCA1 SCD

1.18e-052120214967823
Pubmed

Motor dysfunction and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in mice lacking potassium channels Kv3.1 and Kv3.3.

KCNC1 KCNC3

1.18e-052120212930807
Pubmed

Kv3 potassium channels control the duration of different arousal states by distinct stochastic and clock-like mechanisms.

KCNC1 KCNC3

1.18e-052120216553620
Pubmed

TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells.

ANO1 PKD1

1.18e-052120232185407
Pubmed

Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cells.

CACNA1C CACNA1D

1.18e-052120221054386
Pubmed

Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse.

KCNC1 KCNC3

1.18e-052120235510987
Pubmed

Behavioral motor dysfunction in Kv3-type potassium channel-deficient mice.

KCNC1 KCNC3

1.18e-052120216923152
Pubmed

An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.

CACNA1C CACNA1D

1.18e-052120224086669
Pubmed

Subcellular localization of the voltage-gated potassium channels Kv3.1b and Kv3.3 in the cerebellar dentate nucleus of glutamic acid decarboxylase 67-green fluorescent protein transgenic mice.

KCNC1 KCNC3

1.18e-052120218682278
Pubmed

Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3.

CACNA1C CACNA1D

1.18e-052120226049024
Pubmed

Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.

CACNA1C CACNA1D

1.18e-052120219225208
Pubmed

Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB.

CACNA1C CACNA1D

1.18e-052120216706838
Pubmed

Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures.

CACNA1C CACNA1D

1.18e-052120223761887
Pubmed

Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.

CACNA1C CACNA1D

1.18e-052120214981074
Pubmed

CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.

CACNA1C CACNA1D

1.18e-052120225292336
Pubmed

Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.

CACNA1C CACNA1D

1.18e-052120217526649
Pubmed

Ligand-activated signal transduction in the 2-cell embryo.

CACNA1C CACNA1D

1.18e-052120212606379
Pubmed

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.

CACNA1C CACNA1D

1.18e-052120224941892
Pubmed

Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells.

CACNA1C CACNA1D

1.18e-052120222826131
Pubmed

Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization.

CACNA1C CACNA1D

1.18e-052120224470632
Pubmed

Down-regulation of the small conductance calcium-activated potassium channels in diabetic mouse atria.

KCNN2 KCNN3

1.18e-052120225605734
Pubmed

Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neurons.

CACNA1C CACNA1D

1.18e-052120224760982
Pubmed

Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia.

KCNN2 KCNN3

1.18e-052120211395478
Pubmed

Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons.

CACNA1C CACNA1D

1.18e-052120220014384
Pubmed

Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage.

OMA1 OPA1

1.18e-052120224719224
Pubmed

Ablation of Kv3.1 and Kv3.3 potassium channels disrupts thalamocortical oscillations in vitro and in vivo.

KCNC1 KCNC3

1.18e-052120218495891
Pubmed

Role of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels.

CACNA1C CACNA1D

1.18e-052120230001160
Pubmed

Distribution of Ca2+-activated K channels, SK2 and SK3, in the normal and Hirschsprung's disease bowel.

KCNN2 KCNN3

1.18e-052120212778407
Pubmed

Role of SK channel activation in determining the action potential configuration in freshly isolated human atrial myocytes from the SKArF study.

KCNN2 KCNN3

1.18e-052120230922569
Pubmed

Increased motor drive and sleep loss in mice lacking Kv3-type potassium channels.

KCNC1 KCNC3

1.18e-052120215005717
Pubmed

Rescue and worsening of congenital heart block-associated electrocardiographic abnormalities in two transgenic mice.

CACNA1C CACNA1D

1.18e-052120221352396
Pubmed

Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels.

KCNN2 KCNN3

1.18e-052120227874831
Pubmed

Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo.

ANO1 PKD1

1.18e-052120232859916
Pubmed

Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.

CACNA1C CACNA1D

1.18e-052120217409250
Pubmed

Neuronal L-type calcium channels open quickly and are inhibited slowly.

CACNA1C CACNA1D

1.18e-052120216267232
Pubmed

OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury.

OMA1 OPA1

1.18e-052120224671334
Pubmed

Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD.

OMA1 OPA1

1.18e-052120239039850
Pubmed

The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function.

CACNA1C CACNA1D

1.18e-052120224996399
Pubmed

SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons.

KCNN2 KCNN3

1.18e-052120222554781
Pubmed

Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice.

OMA1 OPA1

1.18e-052120222433842
Pubmed

Expression of postsynaptic Ca2+-activated K+ (SK) channels at C-bouton synapses in mammalian lumbar -motoneurons.

KCNN2 KCNN3

1.18e-052120223129791
Pubmed

Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesis.

JAK2 PKD1

1.18e-052120230872773
Pubmed

Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability.

CACNA1C PKD1

1.18e-052120225888683
Pubmed

Spinocerebellar ataxia-13 Kv3.3 potassium channels: arginine-to-histidine mutations affect both functional and protein expression on the cell surface.

KCNC1 KCNC3

1.18e-052120223734863
Pubmed

Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3.

KCNN2 KCNN3

1.18e-052120210988076
Pubmed

Preferential formation of human heteromeric SK2:SK3 channels limits homomeric SK channel assembly and function.

KCNN2 KCNN3

1.18e-052120236502918
Pubmed

Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics.

OMA1 OPA1

1.18e-052120224550258
Pubmed

Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.

CACNA1C CACNA1D

1.18e-052120224849370
Pubmed

Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I.

SPTLC3 SPTLC2

1.18e-052120220920666
Pubmed

A novel isoform of SK2 assembles with other SK subunits in mouse brain.

KCNN2 KCNN3

1.18e-052120215797870
Pubmed

Rescue of motor coordination by Purkinje cell-targeted restoration of Kv3.3 channels in Kcnc3-null mice requires Kcnc1.

KCNC1 KCNC3

1.18e-052120220016089
Pubmed

Divide and conquer: an L-type voltage-gated calcium channel subtype finds a role in conditioned fear.

CACNA1C CACNA1D

1.18e-052120217015854
Pubmed

Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants.

KCNC1 KCNC3

1.18e-052120218448641
Pubmed

Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area.

CACNA1C CACNA1D

1.18e-052120224848473
Pubmed

Allele-dependent changes of olivocerebellar circuit properties in the absence of the voltage-gated potassium channels Kv3.1 and Kv3.3.

KCNC1 KCNC3

1.18e-052120215217387
Pubmed

Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3.

KCNC1 KCNC3

1.18e-052120211517255
Pubmed

CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.

OMA1 CPT2 JAK2 SCD RBPJ PLCL2

1.22e-05146120629688375
Pubmed

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

ARHGAP23 ANO1 LAMA5 SLC26A9 NCCRP1 GSN ATP6V1H CLU GALNT4

1.52e-05417120919199708
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

LSG1 RGS19 WDR55 LAMA5 CCDC50 INTS8 NDUFS3 STRIP1 TSR1 SCD SIPA1L1 MACF1 CTBP1 MTREX PSPC1 PLEKHA7 C8orf33

1.56e-0514971201731527615
Pubmed

Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.

OPA1 NDUFS3 ATP6V1H CLU SCD UMPS CTBP1 PSPC1

1.73e-05323120824797263
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

TMEM248 DEF8 CCDC50 COLGALT1 CPT2 MESD TSR1 SCD SIPA1L1 RBPJ PLCL2 MACF1 PLEKHA7 TMEM18

2.34e-0510841201411544199
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ATRN SPTLC2 ZNF862 LAMA5 OPA1

3.30e-0510512059628581
Pubmed

Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.

DEPTOR OPA1 MAGED2 SCD

3.46e-0553120435216969
Pubmed

Molecular properties of small-conductance Ca2+-activated K+ channels expressed in murine colonic smooth muscle.

KCNN2 KCNN3

3.53e-053120211557517
Pubmed

Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain.

KCNN2 KCNN3

3.53e-053120211146124
Pubmed

De novo point mutations in patients diagnosed with ataxic cerebral palsy.

SPTBN2 KCNC3

3.53e-053120225981959
Pubmed

Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes.

KCNN2 KCNN3

3.53e-053120216055520
Pubmed

Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca2+ Signals.

ANO1 PKD1

3.53e-053120234199520
Pubmed

Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease.

OMA1 OPA1

3.53e-053120234400172
Pubmed

Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP).

CACNA1C CACNA1D

3.53e-053120217767505
Pubmed

ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation.

ABCA1 JAK2

3.53e-053120218776170
Pubmed

Regulation of Janus Kinase 2 by an Inflammatory Bowel Disease Causal Non-coding Single Nucleotide Polymorphism.

JAK2 RBPJ

3.53e-053120232271392
Pubmed

Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.

CACNA1C CACNA1D

3.53e-05312022173707
Pubmed

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.

OMA1 OPA1

3.53e-053120226783299
Pubmed

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

SPTLC3 SPTLC2

3.53e-053120217331073
Pubmed

Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents.

KCNN2 KCNN3

3.53e-053120215190101
Pubmed

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons.

KCNN2 KCNN3

3.53e-053120224434522
Pubmed

Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile.

ABCA1 JAK2

3.53e-053120218239666
Pubmed

Binding of gelsolin, a secretory protein, to amyloid beta-protein.

GSN CLU

3.53e-053120210329371
Pubmed

p53 is required for cisplatin-induced processing of the mitochondrial fusion protein L-Opa1 that is mediated by the mitochondrial metallopeptidase Oma1 in gynecologic cancers.

OMA1 OPA1

3.53e-053120225112877
Pubmed

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.

CACNA1C CACNA1D

3.53e-053120226831068
Pubmed

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice.

OMA1 OPA1

3.53e-053120226785494
Pubmed

m-AAA and i-AAA complexes coordinate to regulate OMA1, the stress-activated supervisor of mitochondrial dynamics.

OMA1 OPA1

3.53e-053120229545505
Pubmed

Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.

CACNA1C CACNA1D

3.53e-053120223338940
Pubmed

Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain.

KCNN2 KCNN3

3.53e-053120215234350
GeneFamilyPolypeptide N-acetylgalactosaminyltransferases

GALNTL6 GALNT2 GALNT12 GALNT4

1.98e-0620844433
GeneFamilyPotassium calcium-activated channels

KCNN2 KCNN3

3.16e-046842255
GeneFamilyEF-hand domain containing|Spectrins

SPTBN2 SPTBN5

4.41e-0478421113
GeneFamilyCation channels sperm associated

CATSPERD CATSPER1

4.41e-047842186
GeneFamilyATP binding cassette subfamily A

ABCA1 ABCA4

1.87e-0314842805
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCD4 PLCL2

3.46e-0319842832
CoexpressionLAKE_ADULT_KIDNEY_C6_PROXIMAL_TUBULE_EPITHELIAL_CELLS_FIBRINOGEN_POS_S3

SPTLC3 RNF19A SNX13 CLU SIPA1L1 NT5C2 PLEKHA1 MACF1

1.93e-061811208M39225
CoexpressionGSE21927_SPLENIC_VS_TUMOR_MONOCYTES_FROM_C26GM_TUMOROUS_MICE_BALBC_DN

DET1 RBL2 ZNF862 INTS8 CEP350 EFHC1 TECPR2 MACF1

3.75e-061981208M7605
CoexpressionGSE32255_WT_VS_JMJD2D_KNOCKDOWN_4H_LPS_STIM_DC_UP

RANBP10 SYNM RNF19A GSN TECPR2 PLCL2 GALNT4

7.51e-061551207M8913
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

DOCK1 CUL2 ATRN SMARCA5 PDE8A ARHGAP35 OPA1 SNX13 CEP350 ATP6V1H SIPA1L1 RBPJ NT5C2 MACF1 MTREX

8.85e-0685612015M4500
CoexpressionGSE40274_CTRL_VS_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN

SMARCA5 JADE3 LSG1 MESD KCNC3 PLCL2 UMPS

1.48e-051721207M9089
CoexpressionGSE25123_WT_VS_PPARG_KO_MACROPHAGE_ROSIGLITAZONE_STIM_UP

SPTLC3 PDE9A ARHGAP35 SNX13 LGI2 PLEKHA1 GALNT4

3.90e-052001207M7978
CoexpressionGSE7852_LN_VS_FAT_TREG_DN

GALNT2 ARHGAP23 GSN FZD4 RBPJ PLCL2 PLEKHA7

3.90e-052001207M5742
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1D SPTLC3 DEPTOR GALNT2 PDE9A RNF19A CLU PLEKHA1 PLEKHA7 TNS3

1.57e-10197120107e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs|Myeloid_cells / Location, Cell class and cell subclass

PDE9A SYNM WEE1 GALNT12 FBXW8 TRIM62 PLEKHA1

3.88e-071691207bea8aba1f3cc3d0e8d448c1c45f5354d26ebf850
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 ABCA4 DEPTOR PDE9A WDR91 PLEKHA1 TNS3

7.67e-071871207c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellPND01-Mesenchymal-Mesenchymal_structural|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D SYNM GSN MESD FHOD1 MACF1 TNS3

1.01e-0619512076bb6349d6ec8da094fe1c7c590021989337aeb0b
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D SYNM GSN MESD FHOD1 MACF1 TNS3

1.01e-061951207a3b468125e48f072255cede7645f6692298ecf54
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

CACNA1D GSN MESD MAGED2 FHOD1 MACF1 TNS3

1.05e-06196120754f4cf778f95a9ff662e5c7520916a25e605bf95
ToppCellE18.5-Mesenchymal-Mesenchymal_structural|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MESD MAGED2 FHOD1 MACF1 TNS3

1.05e-06196120797e26622d9582b092c18ff5b7e957818f99d9631
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MESD MAGED2 FHOD1 MACF1 TNS3

1.05e-061961207617103f4a09e009fe96c28eb5e40505a4fd6dcf4
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MESD MAGED2 FHOD1 MACF1 TNS3

1.05e-061961207f429f045ba45e24717963315832150b12a115bfa
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MESD MAGED2 FHOD1 MACF1 TNS3

1.05e-061961207db64ab27374f82553ee577aec056141170f3656f
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D SYNM GSN MESD FHOD1 MACF1 TNS3

1.09e-06197120706a0d7062dadda656decaf77dcef9a10b5f2698d
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D SYNM GSN MESD FHOD1 MACF1 TNS3

1.09e-061971207d35c7a36135b5ed6a7bf2f934849678eba2a0177
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231|Adult / Lineage, Cell type, age group and donor

ARHGAP23 SYNM HSPA12B FZD4 KCNN2 FUT1

6.15e-0616712065af9127bae05768a5164d5708a4ad37edca99324
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs|normal_Pleural_Fluid / Location, Cell class and cell subclass

PDE9A SYNM GALNT12 FBXW8 TRIM62 PLEKHA7

8.31e-0617612067a74217b7fa1032b918f00a3972dff5fab74671a
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MESD MAGED2 FHOD1 MACF1

9.15e-061791206948c2a01ec7a626c68281e6e796a9f0527a88591
ToppCellMatrixFB-Fibroblast-A|MatrixFB / shred on cell class and cell subclass (v4)

CACNA1D SYNM GSN MESD MACF1 TNS3

9.44e-061801206adc64ad6033af705dd7b9163a83e20ef5c59f6eb
ToppCellfacs-Kidney-nan-3m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK1 ATRN GSN FZD4 MTREX NME7

1.01e-0518212064c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 ABCA4 DEPTOR WDR91 PLEKHA1 TNS3

1.14e-051861206f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 ABCA4 DEPTOR WDR91 PLEKHA1 TNS3

1.21e-051881206af740fa78542438fdff627ea1f74f4eee43316be
ToppCellTransplant_Alveoli_and_parenchyma-Endothelial-Lymphatic|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

ABCA4 ARHGAP23 SYNM HSPA12B PKHD1L1 KCNN3

1.28e-0519012068d6ec2fc0af19a5cb16fff34f8b131b71b33d45f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNM ANO1 JAK2 LGI2 IGSF9B MYO18B

1.36e-051921206bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1D GSN MESD FHOD1 MACF1 TNS3

1.36e-0519212062802fae55683345ff94a1ecf73b6fbee4f17481e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNM ANO1 JAK2 LGI2 IGSF9B MYO18B

1.36e-051921206b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 DEPTOR WEE1 ZNF331 WDR91 PLEKHA1

1.40e-051931206ca7c0a4ceb05bced90f6cdc53d278e547fb241e9
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MESD FHOD1 MACF1 TNS3

1.40e-0519312068d05805295c5d3aa93aeb38be5fbefa81e1be1f0
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MESD FHOD1 MACF1 TNS3

1.40e-0519312061b2cc627b2aa002b442358bd1188d470e67ce7d9
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1D GSN MAGED2 FHOD1 MACF1 TNS3

1.44e-051941206f15e81ff12525523c62d13105cf264ea72205e2e
ToppCellPND01-03-samps-Mesenchymal|PND01-03-samps / Age Group, Lineage, Cell class and subclass

CACNA1D GSN MESD MAGED2 MACF1 TNS3

1.44e-0519412064f9bd0ded0dde1df885850714f29e73e992539a5
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MESD FHOD1 MACF1 TNS3

1.49e-051951206b616ee6f1d878935d293c8e0a8bbc5b4385301f0
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MAGED2 FHOD1 MACF1 TNS3

1.49e-051951206598b69032a8441a23749b27863d80f7a1fc82a96
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MAGED2 FHOD1 MACF1 TNS3

1.49e-0519512068aa753934debffe5ae4b5eecb6b50c46d17cc3ec
ToppCellPND07-Mesenchymal-Mesenchymal_structural|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MESD FHOD1 MACF1 TNS3

1.49e-0519512062f9a274b26fc528a85f50933ec2f4db1dc9da0ca
ToppCellE16.5-Mesenchymal-Mesenchymal_structural|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MAGED2 FHOD1 MACF1 TNS3

1.67e-0519912062cec0e370ee9bb3c88a7acb5519e9ea8ddb399bc
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MAGED2 FHOD1 MACF1 TNS3

1.67e-0519912069e87b64e16d595701c3beb07aa835afe3330bd10
ToppCellLPS-IL1RA-Unknown-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPTBN2 PKD1 KCNN2 FUT1 PLEKHA7

1.71e-051181205aefad0b35aff980b6a2a98057735442e8a65ab04
ToppCellLPS-IL1RA-Unknown|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPTBN2 PKD1 KCNN2 FUT1 PLEKHA7

1.71e-0511812056cb4063b83f867b782080ce5b1199b51bb277f2a
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA5 HSPA12B ZNF331 FZD4 KCNN2 FUT1

1.72e-0520012063653002c805c314043e2a7b0c9980dfe952dc53e
ToppCellControl-Epithelial_alveolar-AT_1-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA4 UBXN11 KCNN2 C5 PLEKHA7

3.62e-051381205611fe0fb284e12678f9c47a0bdbfc367a93c52b3
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 ABCA4 WDR91 PLEKHA1 TNS3

3.62e-051381205a88c3ae56b0af60f6e87cabade4f21e2bbb336f2
ToppCellP07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1D GSN FHOD1 MACF1 TNS3

7.54e-051611205b19f82dd98a3064581793711bb70373f18abecd9
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|E18.5-samps / Age Group, Lineage, Cell class and subclass

CACNA1D GSN FHOD1 MACF1 TNS3

8.23e-051641205519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-stromal_related-FDC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNM SLC26A9 LGI2 CLU IGSF9B

9.48e-05169120549a54fb2ea9db5c45e107f304838c536908308bb
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 SPTLC2 LGI2 PLEKHA1 TNS3

9.74e-0517012055d5f208682be21ed58320f5fc083a7898f8712da
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-mLTo|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA5 VAT1L SPTBN5 LGI2 TNS3

9.74e-0517012057653f1205d4e62abe7e31b1d76f9bbd665e45667
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122|Adult / Lineage, Cell type, age group and donor

HSPA12B ZNF331 FZD4 KCNN2 FUT1

1.00e-041711205bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C CACNA1D AFF2 GPR158 IGSF9B

1.09e-041741205f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NCCRP1 KCNC3 KCNN2 IGSF9B MYO18B

1.09e-04174120516204ff504b7b382b4d90ca35003ad5336020e07
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNM PKHD1L1 TRIM62 KCNN3 IGSF9B

1.12e-0417512050801cccec6915aefc135262fc74580280fd51aa5
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNM PKHD1L1 TRIM62 KCNN3 IGSF9B

1.12e-04175120509163e7030f76d706eccabdb1d5ec45f8412aa75
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-conventional_dendritic_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DOCK1 DEPTOR CCDC50 GSN KCNC3

1.12e-041751205c58a1f02d1e559d3638fe1500e960e82a8a7187b
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D GSN MESD MACF1 TNS3

1.15e-041761205cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCell5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA4 SYNM HSPA12B PKHD1L1 KCNN2

1.21e-0417812054b3ea0921bc598ebb9f63780ecdf8ad4349f3666
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C CACNA1D ABCA1 AFF2 GPR158

1.21e-041781205fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA4 SYNM PKHD1L1 NCCRP1 KCNN2

1.24e-04179120540c65e8623547aeb80f9cd2366e29072467ce069
ToppCellCOVID-19-kidney-vSMC/Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1C PDE8A SYNM ANO1 LGI2

1.24e-041791205111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-epithelial_progenitor_cell-CLDN10+_cells|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC26A9 SCGN NCCRP1 CLU RBPJ

1.24e-0417912057eca1e19ae6b5b1f18c721691dc3e860705628f2
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GALNTL6 ABCA1 CCDC50 NCF4 ZNF331

1.24e-041791205a28a1de500a74c6dcc43481abf9ec0f7e7a300a9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 DEPTOR LGI2 PLEKHA1 TNS3

1.31e-0418112059d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DEPTOR SPTLC2 LGI2 KCNC3 TNS3

1.31e-041811205071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

CACNA1D GSN FHOD1 MACF1 TNS3

1.34e-041821205ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell3'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA4 HSPA12B PKHD1L1 KCNN2 FUT1

1.34e-04182120582d6f72649c7dd4d64a84a9795edebdef2f285d6
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DOCK1 DEPTOR SPTLC2 GSN KCNC3

1.34e-0418212059a68d3bd1cc9139de9e9e711c249d47ade826bb1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 DEPTOR LGI2 PLEKHA1 TNS3

1.34e-041821205eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DOCK1 DEPTOR SPTLC2 GSN KCNC3

1.34e-041821205d57d18732aa6fb7b2d430601568f9ba525ac6e3c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DOCK1 DEPTOR SPTLC2 GSN KCNC3

1.34e-041821205c3fb1460160744144aa31afc76c0a4d42ebdeb91
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK1 PDE8A ARHGAP23 GSN SCD

1.38e-0418312055472cdce6d99314d229418412acf1fff6340db7d
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1D SPTLC3 FZD4 KIF9 C8orf33

1.38e-041831205dc9602bed3136db91faeffef177006246dc92743
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1C AFF2 PDE9A SYNM ANO1

1.45e-041851205a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCell3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_mucus_secreting_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GALNTL6 DEPTOR ANO1 GALNT12 SCGN

1.45e-041851205d9039770226338fbc3fce92aa229fad96e16db8c
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENGASE ARHGAP23 PKHD1L1 UBXN11 KCNN3

1.45e-041851205bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATRN ABCA1 DEPTOR LGI2 RBPJ

1.45e-0418512058207f9eff113eed429e961748c6b17d672a13b33
ToppCell3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_mucus_secreting_cell-SMG_mucous|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GALNTL6 DEPTOR ANO1 GALNT12 SCGN

1.45e-041851205b931ab35da10e6e3877071dce9b13fc0da63dc88
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 DEPTOR LGI2 KCNC3 CLU

1.48e-0418612053dae539cce15fcf2b1b32e981d7febe94c03c600
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA4 SYNM HSPA12B PKHD1L1 NCCRP1

1.48e-0418612059579180db2a0bf3f043b4d169f9a08cdc45b459a
ToppCelltumor_Lung-Epithelial_cells-tS3|Epithelial_cells / Location, Cell class and cell subclass

CATSPERD KIF9 EFHC1 UBXN11 KCNN3

1.52e-0418712053cea677279e71fdb9879530dea10a5e6393beacd
ToppCellControl-Endothelial-VE_Capillary_A|Control / Disease state, Lineage and Cell class

LAMA5 HSPA12B FZD4 KCNN2 FUT1

1.52e-04187120554d7588172ac145ff5045ad9771636729ca3f0ca
ToppCellE16.5-samps-Mesenchymal|E16.5-samps / Age Group, Lineage, Cell class and subclass

CACNA1D MAGED2 FHOD1 MACF1 TNS3

1.56e-0418812053f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Adult / Lineage, Cell type, age group and donor

HSPA12B ZNF331 FZD4 KCNN2 FUT1

1.56e-041881205e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCellFibroblast-A|World / shred on cell class and cell subclass (v4)

CACNA1D GSN MESD MAGED2 MACF1

1.56e-0418812056740bed5fb8f45b6eea17041894b804214c2a4ae
ToppCelldroplet-Lung-nan-18m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC26A9 PLCD4 KCNC3 SCD KCNN2

1.60e-041891205ca657353f2b649530809c0bc057e448adc511ec1
ToppCellIPF-Endothelial-VE_Capillary_A|World / Disease state, Lineage and Cell class

SYNM HSPA12B FZD4 KCNN2 FUT1

1.60e-041891205ea3aa3ef38f1d405bb527ae383cd12c551a3dd6f
ToppCelldroplet-Lung-nan-18m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC26A9 PLCD4 KCNC3 SCD KCNN2

1.60e-041891205e5325f1c7430b574947f8ee67e425455b60dc518
ToppCellfacs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA1 GSN SNX13 MACF1 MTREX

1.60e-041891205875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABCA1 DEPTOR NCF4 LGI2 RBPJ

1.64e-041901205f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DEPTOR SPTLC2 NCF4 SIPA1L1 RBPJ

1.64e-0419012052d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCellIPF-Endothelial-VE_Capillary_A|IPF / Disease state, Lineage and Cell class

SYNM HSPA12B FZD4 KCNN2 FUT1

1.64e-041901205b4e35cbfe4d43d2cd51f29c3085e4d9b1012e6f0
ToppCellASK454-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

CATSPERD WEE1 EFHC1 UBXN11 CLU

1.64e-0419012055cea6480f08253d7adf484e511d3fdfa96641268
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN2 C4orf54 KCNC3 CLU PLCL2

1.64e-041901205078f4be52fa4cc8dd9c8d7a2b6d9631c3d902285
ToppCellLV-08._Macrophage|World / Chamber and Cluster_Paper

SPTLC2 NCF4 SIPA1L1 RBPJ TNS3

1.68e-041911205e7a0bc46ba9ba772636a583f3387748418e18832
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal|E16.5-samps / Age Group, Lineage, Cell class and subclass

CACNA1D MAGED2 FHOD1 MACF1 TNS3

1.68e-0419112053379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

CACNA1D GSN MESD FHOD1 MACF1

1.68e-041911205e7c605b56934d1383237c1f946dbccef25d91368
ToppCellRV-08._Macrophage|World / Chamber and Cluster_Paper

SPTLC2 NCF4 SIPA1L1 RBPJ TNS3

1.72e-041921205a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCellLV-08._Macrophage|LV / Chamber and Cluster_Paper

SPTLC2 NCF4 SIPA1L1 RBPJ TNS3

1.72e-0419212057be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1D GSN FHOD1 MACF1 TNS3

1.72e-0419212050afb9dbe468e0be442c326e11c5fc0f699b32f23
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-conventional_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

DEPTOR CCDC50 GSN JAK2 RBPJ

1.72e-0419212058e606eae3e5b07a856d3c2a74186d486da96309c
ToppCellP03-Mesenchymal-mesenchymal_fibroblast|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1D GSN MESD MACF1 TNS3

1.72e-041921205e79f2253e084a9ab9afcaf7ec42a5012ade42d36
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GALNTL6 AFF2 ANO1 KCNC1 LGI2

1.72e-0419212050003d7ef9a8e521e70ac33c63aad843d9b6215c2
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

PDE8A SIPA1L1 SCAPER MACF1 PLEKHA7

1.72e-041921205e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMARCA5 GSN SNX13 CEP350 MACF1

1.76e-04193120506b65110db974f4ef90d3511ff34428976a52c9c
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ABCA1 PDE8A SIPA1L1 PLEKHA7 TNS3

1.76e-041931205779276e775cb2492e8dd36436295a536084a6415
Drugmibefradil

CACNA1C CACNA1D CATSPER1 PKD1 KCNN3

2.14e-05641195CID000060662
DrugCNS 1145

CACNA1C CACNA1D CATSPER1 PKD1

2.58e-05331194CID000190902
DrugIHC-64

CACNA1C CACNA1D CATSPER1 PKD1

2.58e-05331194CID000162753
Druggallopamil

CACNA1C CACNA1D NOD2 CATSPER1 PKD1

2.67e-05671195CID000001234
Drugcyclohexyl-(2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl)amine

KCNN2 KCNN3

2.71e-0521192ctd:C552889
Drugfelodipine

CACNA1C CACNA1D PDE8A PDE9A NOD2 CATSPER1 PKD1

3.06e-051691197CID000003333
Drugtetraethylammonium

CACNA1C CACNA1D NOD2 KCNC1 KCNC3 PKD1 KCNN2 KCNN3

3.45e-052361198CID000005413
Drugpapaverine

CACNA1C CACNA1D PDE8A PDE9A PLCD4 CATSPER1 PKD1

3.96e-051761197CID000004680
DrugCAS 298-57-7

CACNA1C CACNA1D NOD2 CATSPER1 PKD1

4.05e-05731195CID000002761
DrugLanatoside C [17575-22-3]; Down 200; 4uM; MCF7; HT_HG-U133A

DET1 SYNM SPTLC2 CPT2 JAK2 FHOD1 C5

4.73e-0518111976048_DN
DrugN-cyclopentyl-N-cyclobutylformamide

CACNA1C CACNA1D CATSPER1 KCNC3 PKD1

5.93e-05791195CID005287890
DrugGriseofulvin [126-07-8]; Down 200; 11.2uM; HL60; HT_HG-U133A

ATRN SPTLC2 CPT2 WDR91 EFHC1 SCAPER MACF1

7.10e-0519311972332_DN
DrugMeclozine dihydrochloride [1104-22-9]; Up 200; 8.6uM; MCF7; HT_HG-U133A

RANBP10 ABCA1 DEPTOR SPTLC2 ZNF862 SPTBN2 PLCL2

7.33e-0519411973285_UP
Drug6-propionyl-2-(dimethylamino)naphthalene

SPTBN2 SPTBN5 NLRP14

7.42e-05161193CID000107729
DrugOxamniquine [21738-42-1]; Up 200; 14.4uM; HL60; HT_HG-U133A

CACNA1D AFF2 ARHGAP35 GSN SNX13 NOD2 UMPS

7.57e-0519511972924_UP
DrugBrompheniramine maleate [980-71-2]; Down 200; 9.2uM; MCF7; HT_HG-U133A

CACNA1D DEPTOR SPTLC2 ARHGAP35 GSN BRF1 SCAPER

7.82e-0519611973271_DN
Drugchlorpromazine hydrochloride; Down 200; 10uM; MCF7; HG-U133A

ATRN JADE3 WEE1 SPTLC2 RGS19 MAGED2 TECPR2

7.82e-051961197419_DN
DrugFamprofazone [22881-35-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A

ABCA1 RNF19A JAK2 SIPA1L1 SCAPER KCNN2 C5

7.82e-0519611976029_DN
Drugfluphenazine dihydrochloride; Down 200; 10uM; HL60; HT_HG-U133A

ENGASE CUL2 ABCA1 SMARCA5 PDE8A RGS19 TSR1

7.82e-0519611971178_DN
DrugRauwolscine hydrochloride [6211-32-1]; Up 200; 10.2uM; MCF7; HT_HG-U133A

CACNA1D SPTBN2 WDR55 SNX13 JAK2 BRF1 FUT1

7.82e-0519611972778_UP
Drugchlorpromazine hydrochloride; Up 200; 1uM; MCF7; HT_HG-U133A

CACNA1D SYNM RNF19A SPTLC2 ZNF862 SPTBN5 SCAPER

8.07e-0519711976936_UP
DrugHydroflumethiazide [135-09-1]; Down 200; 12uM; PC3; HT_HG-U133A

RNF19A ARHGAP35 ZMAT5 BRF1 CLU TRIM62 FUT1

8.07e-0519711971809_DN
DrugPicotamide monohydrate [80530-63-8]; Down 200; 10.2uM; PC3; HT_HG-U133A

DET1 LSG1 GALNT12 CEP350 TRIM62 SCAPER IFT122

8.07e-0519711972070_DN
DrugCefotiam hydrochloride; Up 200; 7.2uM; MCF7; HT_HG-U133A

CUL2 ZNF862 SPTBN2 ARHGAP35 SIPA1L1 SCAPER FUT1

8.33e-0519811975361_UP
DrugGuanadrel sulfate [22195-34-2]; Down 200; 7.6uM; HL60; HT_HG-U133A

ATRN GALNT2 SPTLC2 NOD2 BRF1 MAGED2 C5

8.33e-0519811972575_DN
DrugCP-863187 [668981-07-5]; Up 200; 10uM; MCF7; HT_HG-U133A

DOCK1 ATRN RANBP10 SPTLC2 RBL2 WDR55 TNS3

8.33e-0519811977553_UP
DrugCephalothin sodium salt [58-71-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A

AFF2 NOD2 BRF1 KCNC1 PLCL2 SCAPER KCNN2

8.33e-0519811976819_UP
DrugIsoconazole [27523-40-6]; Down 200; 9.6uM; MCF7; HT_HG-U133A

CUL2 RANBP10 SPTLC2 OPA1 ZMAT5 TECPR2 C5

8.60e-0519911977211_DN
Drugvaldecoxib; Up 200; 10uM; PC3; HT_HG-U133A

SPTLC3 ZNF862 ARHGAP35 SNX13 SPTBN5 TRIM62 IFT122

8.87e-0520011976408_UP
Diseasehereditary sensory and autonomic neuropathy type 1 (implicated_via_orthology)

SPTLC3 SPTLC2

4.66e-0531172DOID:0070162 (implicated_via_orthology)
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1C CACNA1D

9.30e-0541172DOID:0060173 (implicated_via_orthology)
Diseasesleep duration, high density lipoprotein cholesterol measurement

ABCA1 GALNT2 SNX13 ATP6V1H MACF1

1.24e-041211175EFO_0004612, EFO_0005271
Diseasephospholipids:total lipids ratio, intermediate density lipoprotein measurement

ABCA1 GALNT2 SNX13 MACF1

1.48e-04671174EFO_0008595, EFO_0020946
Diseasemuscular disease (is_implicated_in)

CPT2 CLU

2.31e-0461172DOID:0080000 (is_implicated_in)
Diseasecholesterol:total lipids ratio, low density lipoprotein cholesterol measurement

ABCA1 GALNT2 SCGN SNX13 MACF1

2.79e-041441175EFO_0004611, EFO_0020943
Diseasecolorectal adenoma

CUL2 OMA1 NOD2

3.04e-04331173EFO_0005406
Diseasecholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

RANBP10 ABCA1 GALNT2 SCGN SNX13 MACF1

4.28e-042431176EFO_0004612, EFO_0020944
DiseaseMental deterioration

CACNA1C CLU

5.51e-0491172C0234985
DiseaseMild cognitive disorder

CACNA1C CLU

5.51e-0491172C1270972
DiseaseR-warfarin measurement

GALNTL6 CACNA1C PDE9A GALNT12 CPT2 MYO18B

6.75e-042651176EFO_0803324
DiseaseAnemia, Sickle Cell

CACNA1C UMPS

6.87e-04101172C0002895
Diseaseclonal hematopoiesis

OMA1 JAK2

6.87e-04101172EFO_0010819
DiseaseCrohn Disease

NCF4 NOD2 JAK2

1.04e-03501173C0010346
Diseasemetabolic syndrome

ABCA1 GALNT2 SNX13 NT5C2 TMEM18

1.23e-032001175EFO_0000195
Diseaseelectrocardiography

CACNA1C OMA1 MESD SIPA1L1 KCNN2 KCNN3 MYO18B NME7

1.27e-035301178EFO_0004327
DiseaseImpaired cognition

CACNA1C CLU

1.38e-03141172C0338656
Diseaseresponse to acetylsalicylate

OMA1 KIF9

1.80e-03161172GO_1903492
Diseaseneuroticism measurement, cognitive function measurement

CACNA1C GALNT2 RBL2 NDUFS3 SIPA1L1 PLCL2 PLEKHA1 IGSF9B

1.91e-035661178EFO_0007660, EFO_0008354
DiseaseHDL cholesterol change measurement, physical activity

ABCA1 GALNT2 SNX13

1.94e-03621173EFO_0003940, EFO_0007805
DiseaseColorectal Carcinoma

OMA1 ABCA1 ABCA4 SPTBN2 GALNT12 FZD4 BRF1 UMPS CTBP1

1.96e-037021179C0009402
DiseaseAntibody Deficiency Syndrome

CACNA1C C5

2.04e-03171172C0003257
Diseasephospholipids:total lipids ratio

ABCA1 GALNT2 SCGN SNX13 MACF1

2.15e-032271175EFO_0020946
Diseaseadiponectin measurement

VAT1L SNX13 KIF9 KCNN2

2.77e-031461174EFO_0004502
Diseaseenergy expenditure measurement

KCNC1 GPR158

2.83e-03201172EFO_0008005
Diseaseplatelet component distribution width

CACNA1C GALNT2 WEE1 LAMA5 SCGN C4orf54 KIF9 BRF1 MACF1

3.18e-037551179EFO_0007984
DiseaseAlzheimer disease

OMA1 ABCA1 VAT1L CATSPER1 CLU KCNN3 PLEKHA1

3.26e-034851177MONDO_0004975
Diseasefibrinogen measurement, coronary artery disease

SCGN SNX13 UMPS NME7

3.35e-031541174EFO_0001645, EFO_0004623
DiseaseFEV/FEC ratio

CACNA1D DEPTOR PDE9A RNF19A ANO1 SLC26A9 GALNT12 SPTBN5 EFHC1 SCAPER KCNN3 TMEM18

3.53e-03122811712EFO_0004713
Diseasepulse pressure measurement

CACNA1D DEPTOR PDE8A ANO1 WDR55 LAMA5 INTS8 GSN PKD1 NT5C2 NME7 PLEKHA7 TNS3

3.54e-03139211713EFO_0005763
DiseaseImmunologic Deficiency Syndromes

CACNA1C C5

3.73e-03231172C0021051
Diseasemean arterial pressure

CACNA1D RGS19 NDUFS3 SCD NT5C2 PLEKHA7 TMEM18

3.81e-034991177EFO_0006340

Protein segments in the cluster

PeptideGeneStartEntry
EVEIRGEWYFMALDS

CATSPER1

471

Q8NEC5
ADQYIWSEDVALMFR

CATSPERD

331

Q86XM0
AAWYSEQASIEMREE

CTBP1

316

Q13363
MAHRDQEWYDAEIAR

CCDC50

166

Q8IVM0
SLFGDYRAQMEAEWR

C8orf33

161

Q9H7E9
ADDMANFDWRDIFNI

ABCA4

491

P78363
SMFQDVRDAVDWVHY

NT5C2

196

P49902
MDLFDFFRDWDLEQQ

AFF2

1

P51816
DMLTVEEHIWFYARL

ABCA1

986

O95477
VYLWRRAEQDGSAMA

DET1

301

Q7L5Y6
WFDMYLSARDSVVLN

CPT2

116

P23786
PFLFDIEDYMREWRA

RANBP10

221

Q6VN20
EECVAFMLNWRENEY

INTS8

661

Q75QN2
DDFVMSYLFAQWRHD

JAK2

146

O60674
EDTVWAYFRVMVDSL

NUP107

446

P57740
LNMDEAARAEAWDSY

RBL2

56

Q08999
MPYAQWLAENDRFEE

IFT122

866

Q9HBG6
WAAQYREAMEADLKA

MAGED2

471

Q9UNF1
LLTAEQRSAWAMYFE

LSG1

216

Q9H089
SREFGIWMLEENLHY

LGALS16

66

A8MUM7
DRWDYMTAVAEFLFL

GPR158

576

Q5T848
GADDWRIAMTYERIF

KCNN2

201

Q9H2S1
YNMVLAYDLASREWL

ATRN

366

O75882
FSSDFMAYDIACDRW

ATRN

586

O75882
RDYNDADMARLLEQW

MESD

56

Q14696
TRRAAEVWMDEYKNF

GALNT2

381

Q10471
MDWFEDSRLDACVYE

NCCRP1

181

Q6ZVX7
MDDYSLDEFRRRWQE

FBXW8

1

Q8N3Y1
VIDNGADDWRIAMTY

KCNN3

346

Q9UGI6
PRIARAMENEEYWDF

PDE8A

486

O60658
WVDCLLEEYFMQSDR

PDE9A

476

O76083
EETVREAAMLWLEYN

KBTBD2

191

Q8IY47
VWVLMDEDVRIFFYQ

NCF4

121

Q15080
QMRLNYRWDLTGFEE

ANO1

431

Q5XXA6
HRLLMEFDIWYNESF

KIF9

696

Q9HAQ2
LEFENFSWRGYAQMA

LAMA5

896

O15230
LWAEMQAGDRYVVAD

HSPA12B

306

Q96MM6
DVLELAEKFWYDMAA

MACF1

6001

Q9UPN3
WDAAIYFMEEALQAR

OPA1

741

O60313
NWALFRYSADDSNMA

FZD4

461

Q9ULV1
WMTYRQHRDAEEALD

KCNC1

106

P48547
AVIMDNFDYLTRDWS

CACNA1C

1521

Q13936
DNEFANMWIERTIYT

DOCK1

1451

Q14185
KEWDFYRMFAIAALE

ARV1

136

Q9H2C2
LQNTARAAEVWMDEY

GALNT4

376

Q8N4A0
MDSWVALAAVDSAVY

C5

596

P01031
YERTFMASEFLDWLV

DEPTOR

161

Q8TB45
MLEYVERATWNDRFS

CUL2

26

Q13617
WQEAEFQNMSRELYR

CEP350

356

Q5VT06
VRAAEVWMDEFKELY

GALNT12

381

Q8IXK2
MIRTFYIAAEEVEWD

HEPHL1

731

Q6MZM0
EARWDAMEYDEKLAR

DEF8

56

Q6ZN54
QVLRFYAIWDDTDSM

EFHC1

241

Q5JVL4
DYWSVDPLDRAMAEL

GSN

766

P06396
FTNYNWREEHLERML

ENGASE

301

Q8NFI3
LQLWAFKLDYDSMER

FHOD1

781

Q9Y613
DMWADYILFVDADNL

COLGALT1

156

Q8NBJ5
VRSMEELYSFNRNEW

C4orf54

1261

D6RIA3
SSVEFMQIWRKYDAD

SCGN

106

O76038
MLDNYVRDFKALIDW

SCAPER

136

Q9BY12
AVIMDNFDYLTRDWS

CACNA1D

1461

Q01668
CRYDLDDMDIFWLQE

JADE3

136

Q92613
MNHSERFVFIAEWYD

NME7

1

Q9Y5B8
QYFSEEDMVWRTEGL

PKD1

3016

P98161
AWEPQDYEMVELFLR

PKD1

4121

P98161
VGDSAYLRQAMDWFR

FUT1

236

P19526
KRVAETWMDEFAEYI

GALNTL6

386

Q49A17
VIWMIRDSNCNYEAF

SNX13

276

Q9Y5W8
AFLRTEYSEENMLFW

RGS19

106

P49795
MAEDWNTFLLRFNDL

TMEM248

51

Q9NWD8
QLMLRVNEYRFAWVE

ATP6V1H

206

Q9UI12
FVVMDYDWKSRNDFI

PLCD4

701

Q9BRC7
AMADWLRDYQDLLQV

SYNM

286

O15061
EDIRSYWDLEQEMFG

SLC26A9

766

Q7LBE3
VLEWDHIEMNFRSYD

LGI2

256

Q8N0V4
YEREIWDMFGVFFAN

NDUFS3

166

O75489
RYFLLDADMQSLRWE

PLCL2

161

Q9UPR0
YFSADTQEDMNAWVR

PLEKHA7

261

Q6IQ23
RVDLPEDFQMNYDLW

STRIP1

806

Q5VSL9
WAVRAEDYNKAMELD

SIPA1L1

861

O43166
PLFDLMERVSDDYNW

SPTLC3

136

Q9NUV7
FWYKADISREQAIAM

TNS3

1171

Q68CZ2
ELFDQVHRWVNYESM

CYB5R4

106

Q7L1T6
FAEYLSMDAQRWEEV

SANBR

176

Q6NSI8
RSFIMNEDFYQWLEE

ARHGAP35

456

Q9NRY4
EQFRLLSELEYEAWM

OMA1

231

Q96E52
LKFFRDADEEMAWVQ

SPTBN5

2896

Q9NRC6
AWDTNEEYLFKAMVA

CLTRN

41

Q9HBJ8
YFWMNGDRIDSLLEN

CLU

151

P10909
RYFSAWAEDDHMLIQ

WEE1

361

P30291
AVVRYMFFNREDVLW

TSR1

711

Q2NL82
VAWVIFDEIHYMRDS

MTREX

246

P42285
NMLDLAWERGFVSQY

NOD2

151

Q9HC29
YEEFMLRRWLVADPD

RNF19A

201

Q9NV58
QQFYRDAAEAEAWMG

SPTBN2

1591

O15020
FEFEYASRWKALDEM

PSPC1

271

Q8WXF1
WYEFRVLAVMQDLIS

IGSF9B

681

Q9UPX0
VDIMERQSHDYNWSF

SPTLC2

146

O15270
YLFQAEDRDDMLGWI

ARHGAP23

786

Q9P227
AQRDLYWDVMLENYS

ZNF331

26

Q9NQX6
EAAEMYRKAAWEAYL

UMPS

461

P11172
ANTMAFQNDVYEWAR

SCD

141

O00767
MRAYAACQDALWALD

TECPR2

1171

O15040
MAKLDNADFLYVDAW

PKHD1L1

2166

Q86WI1
EIGDRVMAFVNYNAW

VAT1L

121

Q9HCJ6
AELWMRENAEYLREQ

BRF1

471

Q92994
NLRVWFGDVEAETMY

RBPJ

381

Q06330
FMRFEWANYAAEALG

MYO18B

846

Q8IUG5
EDVAVYFTREEWGML

ZNF862

336

O60290
FWDMAQLRAVVVDDY

WDR55

321

Q9H6Y2
VWYDMFRDAAAILLD

ZMAT5

36

Q9UDW3
AQRDLYRDVMWENYS

ZFP14

26

Q9HCL3
VLDILEDYCMWRNYE

SMARCA5

511

O60264
ILDTREDSFVWYMDN

PLEKHA1

31

Q9HB21
QLMQVYDLAALRDYW

WDR91

51

A4D1P6
NADDMSWLYTFREKF

TRIM62

431

Q9BVG3
AEYINEAAAMNWRLF

TMEM18

66

Q96B42
ALYWDVMLENYRNLV

ZNF836

31

Q6ZNA1
REMERFLSDYGLQWV

UBXN11

141

Q5T124
LDREFMDFADAQWKA

UGT1A8

86

Q9HAW9
WMTYRQHRDAEEALD

KCNC3

186

Q14003
AMLDWAEGSLYQQRF

NLRP14

196

Q86W24