Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	RSBN1 TET1 KDM3B KDM6B	1.04e-04	65	75	4	GO:0016706
GeneOntologyMolecularFunction	histone demethylase activity	RSBN1 KDM3B KDM6B	2.12e-04	31	75	3	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	RSBN1 KDM3B KDM6B	2.33e-04	32	75	3	GO:0140457
GeneOntologyMolecularFunction	steroid hormone binding	ATP1A1 ATP1A3	2.89e-04	7	75	2	GO:1990239
GeneOntologyMolecularFunction	dioxygenase activity	RSBN1 TET1 KDM3B KDM6B	5.08e-04	98	75	4	GO:0051213
GeneOntologyMolecularFunction	demethylase activity	RSBN1 KDM3B KDM6B	6.03e-04	44	75	3	GO:0032451
GeneOntologyMolecularFunction	P-type sodium transporter activity	ATP1A1 ATP1A3	6.14e-04	10	75	2	GO:0008554
GeneOntologyMolecularFunction	P-type sodium:potassium-exchanging transporter activity	ATP1A1 ATP1A3	6.14e-04	10	75	2	GO:0005391
GeneOntologyMolecularFunction	P-type potassium transmembrane transporter activity	ATP1A1 ATP1A3	7.49e-04	11	75	2	GO:0008556
GeneOntologyCellularComponent	postsynapse	FZD9 MAGI2 ANK1 CELSR3 LRFN5 DISC1 ARHGAP44 CRTAC1 CACNA1H GRIK5 ATP1A1 ARHGEF2 ATP1A3 ITPKA	1.57e-05	1018	76	14	GO:0098794
GeneOntologyCellularComponent	neuron to neuron synapse	MAGI2 CELSR3 LRFN5 DISC1 ARHGAP44 CRTAC1 GRIK5 ATP1A1 ARHGEF2 ATP1A3	1.92e-05	523	76	10	GO:0098984
GeneOntologyCellularComponent	postsynaptic density	MAGI2 CELSR3 LRFN5 DISC1 ARHGAP44 CRTAC1 GRIK5 ATP1A1 ARHGEF2	3.71e-05	451	76	9	GO:0014069
GeneOntologyCellularComponent	asymmetric synapse	MAGI2 CELSR3 LRFN5 DISC1 ARHGAP44 CRTAC1 GRIK5 ATP1A1 ARHGEF2	5.72e-05	477	76	9	GO:0032279
GeneOntologyCellularComponent	photoreceptor inner segment membrane	ATP1A1 ATP1A3	7.79e-05	4	76	2	GO:0060342
GeneOntologyCellularComponent	postsynaptic specialization	MAGI2 CELSR3 LRFN5 DISC1 ARHGAP44 CRTAC1 GRIK5 ATP1A1 ARHGEF2	8.58e-05	503	76	9	GO:0099572
GeneOntologyCellularComponent	glutamatergic synapse	FZD9 MAGI2 CELSR3 LRFN5 DISC1 ARHGAP44 CRTAC1 CACNA1H GRIK5 ARHGEF2 ITPKA	1.71e-04	817	76	11	GO:0098978
GeneOntologyCellularComponent	sodium:potassium-exchanging ATPase complex	ATP1A1 ATP1A3	8.41e-04	12	76	2	GO:0005890
Domain	P-type_ATPase_IIC	ATP1A1 ATP1A3	2.49e-04	6	77	2	IPR005775
Domain	Frizzled	FZD1 FZD9	9.01e-04	11	77	2	IPR000539
Domain	Frizzled	FZD1 FZD9	9.01e-04	11	77	2	PF01534
Domain	Frizzled	FZD1 FZD9	9.01e-04	11	77	2	SM01330
Domain	EGF_CA	CELSR3 MATN3 CRTAC1 LTBP3	1.62e-03	122	77	4	SM00179
Domain	EGF-like_Ca-bd_dom	CELSR3 MATN3 CRTAC1 LTBP3	1.72e-03	124	77	4	IPR001881
Domain	-	ATP1A1 ATP1A3	1.94e-03	16	77	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP1A1 ATP1A3	1.94e-03	16	77	2	IPR023298
Domain	Frizzled/SFRP	FZD1 FZD9	1.94e-03	16	77	2	IPR015526
Domain	GPCR_2_secretin-like	FZD1 FZD9 CELSR3	1.95e-03	60	77	3	IPR000832
Domain	GPCR_2-like	FZD1 FZD9 CELSR3	1.95e-03	60	77	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	FZD1 FZD9 CELSR3	2.04e-03	61	77	3	PS50261
Domain	ATPase_P-typ_cation-transptr_C	ATP1A1 ATP1A3	2.19e-03	17	77	2	IPR006068
Domain	Cation_ATPase_C	ATP1A1 ATP1A3	2.19e-03	17	77	2	PF00689
Domain	Cation_ATPase_N	ATP1A1 ATP1A3	2.46e-03	18	77	2	PF00690
Domain	Cation_ATPase_N	ATP1A1 ATP1A3	2.46e-03	18	77	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP1A1 ATP1A3	2.74e-03	19	77	2	IPR004014
Domain	EGF_3	CELSR3 MATN3 CRTAC1 LTBP3 NAGPA	2.86e-03	235	77	5	PS50026
Domain	FRI	FZD1 FZD9	3.04e-03	20	77	2	SM00063
Domain	-	FZD1 FZD9	3.35e-03	21	77	2	1.10.2000.10
Domain	EGF-like_dom	CELSR3 MATN3 CRTAC1 LTBP3 NAGPA	3.66e-03	249	77	5	IPR000742
Domain	HAD-like_dom	ATP1A1 ATP1A3 NT5M	4.26e-03	79	77	3	IPR023214
Domain	Frizzled_dom	FZD1 FZD9	4.37e-03	24	77	2	IPR020067
Domain	JmjC	KDM3B KDM6B	4.37e-03	24	77	2	PF02373
Domain	FZ	FZD1 FZD9	4.37e-03	24	77	2	PS50038
Domain	Fz	FZD1 FZD9	4.37e-03	24	77	2	PF01392
Domain	EGF-like_CS	CELSR3 MATN3 CRTAC1 LTBP3 NAGPA	4.47e-03	261	77	5	IPR013032
Domain	EGF_2	CELSR3 MATN3 CRTAC1 LTBP3 NAGPA	4.77e-03	265	77	5	PS01186
Domain	EGF_CA	MATN3 CRTAC1 LTBP3	5.39e-03	86	77	3	PF07645
Domain	PID	TBC1D4 SHC1	5.92e-03	28	77	2	PF00640
Domain	JMJC	KDM3B KDM6B	7.68e-03	32	77	2	PS51184
Domain	-	ATP1A1 ATP1A3	7.68e-03	32	77	2	3.40.1110.10
Domain	PID	TBC1D4 SHC1	7.68e-03	32	77	2	PS01179
Domain	-	ATP1A1 ATP1A3	7.68e-03	32	77	2	2.70.150.10
Domain	JmjC_dom	KDM3B KDM6B	7.68e-03	32	77	2	IPR003347
Domain	JmjC	KDM3B KDM6B	8.15e-03	33	77	2	SM00558
Pathway	WP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS	FZD1 FZD9 SHC1 PFN3	6.72e-05	66	47	4	M39642
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FZD1 CELSR3 GRK6 ARHGAP44 SHC1 KDM3B CHSY1 CACNA1H KAZALD1 LTBP3 ARHGEF2 KDM6B WRAP53	2.43e-06	1105	84	13	35748872
Pubmed	Immunohistochemical analyses of alpha1 and alpha3 Na+/K+-ATPase subunit expression in medulloblastomas.	ATP1A1 ATP1A3	5.76e-06	2	84	2	21498719
Pubmed	Expression of frizzled genes in mouse costochondral chondrocytes.	FZD1 FZD9	5.76e-06	2	84	2	11334716
Pubmed	All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides.	ATP1A1 ATP1A3	5.76e-06	2	84	2	11546672
Pubmed	Properties and expression of Na+/K+-ATPase α-subunit isoforms in the brain of the swamp eel, Monopterus albus, which has unusually high brain ammonia tolerance.	ATP1A1 ATP1A3	5.76e-06	2	84	2	24391932
Pubmed	TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly.	WRAP53 TERT	5.76e-06	2	84	2	37267110
Pubmed	Na+/K+ ATPase α1 and α3 isoforms are differentially expressed in α- and γ-motoneurons.	ATP1A1 ATP1A3	5.76e-06	2	84	2	23761886
Pubmed	Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells.	TET1 YTHDC2	5.76e-06	2	84	2	37474847
Pubmed	The family of human Na+,K+-ATPase genes. A partial nucleotide sequence related to the alpha-subunit.	ATP1A1 ATP1A3	5.76e-06	2	84	2	3030810
Pubmed	Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.	ATP1A1 ATP1A3	1.73e-05	3	84	2	2822726
Pubmed	Na+/K+-ATPase α isoform deficiency results in distinct spreading depolarization phenotypes.	ATP1A1 ATP1A3	1.73e-05	3	84	2	30819023
Pubmed	Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle.	WRAP53 TERT	1.73e-05	3	84	2	26170453
Pubmed	CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis.	LRFN5 GCH1	1.73e-05	3	84	2	36266731
Pubmed	Glycoprotein nonmetastatic melanoma protein B (GPNMB) promotes the progression of brain glioblastoma via Na+/K+-ATPase.	ATP1A1 ATP1A3	1.73e-05	3	84	2	27836549
Pubmed	Identification of a VxP Targeting Signal in the Flagellar Na+ /K+ -ATPase.	ATP1A1 ATP1A3	1.73e-05	3	84	2	26373354
Pubmed	Differential expression of Na+/K+-ATPase alpha-subunits in mouse hippocampal interneurones and pyramidal cells.	ATP1A1 ATP1A3	1.73e-05	3	84	2	17947306
Pubmed	Telomerase recruitment requires both TCAB1 and Cajal bodies independently.	WRAP53 TERT	1.73e-05	3	84	2	22547674
Pubmed	MAGI2-AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2.	MAGI2 TET1	1.73e-05	3	84	2	32730644
Pubmed	Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders.	ATP1A1 ATP1A3	1.73e-05	3	84	2	19058785
Pubmed	Knockout of sodium pump α3 subunit gene (Atp1a3-/-) results in perinatal seizure and defective respiratory rhythm generation.	ATP1A1 ATP1A3	1.73e-05	3	84	2	28465228
Pubmed	Developmental cell-specific regulation of Na(+)-K(+)-ATPase alpha 1-, alpha 2-, and alpha 3-isoform gene expression.	ATP1A1 ATP1A3	1.73e-05	3	84	2	8203495
Pubmed	Ankyrin facilitates intracellular trafficking of alpha1-Na+-K+-ATPase in polarized cells.	ANK1 ATP1A1	1.73e-05	3	84	2	18768923
Pubmed	Na,K-ATPase and the role of alpha isoforms in behavior.	ATP1A1 ATP1A3	1.73e-05	3	84	2	18044013
Pubmed	Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase.	ATP1A1 ATP1A3	1.73e-05	3	84	2	26988030
Pubmed	Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model.	ATP1A1 ATP1A3	1.73e-05	3	84	2	26911348
Pubmed	Cardiac glycosides induced toxicity in human cells expressing α1-, α2-, or α3-isoforms of Na-K-ATPase.	ATP1A1 ATP1A3	1.73e-05	3	84	2	25994790
Pubmed	Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.	IRS4 TET1 SAP30L ATP1A1	1.80e-05	64	84	4	22865885
Pubmed	Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2.	ATP1A1 ATP1A3	3.45e-05	4	84	2	21731499
Pubmed	The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice.	ATP1A1 ATP1A3	3.45e-05	4	84	2	12458206
Pubmed	Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.	IRS4 SHC1	3.45e-05	4	84	2	15316024
Pubmed	Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.	ATP1A1 ATP1A3	3.45e-05	4	84	2	21849490
Pubmed	Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes.	ATP1A1 ATP1A3	3.45e-05	4	84	2	17446412
Pubmed	Na,K-ATPase expression in the mouse cochlea is not dependent on the mineralocorticoid receptor.	ATP1A1 ATP1A3	3.45e-05	4	84	2	11591489
Pubmed	Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1.	ATP1A1 ATP1A3	3.45e-05	4	84	2	19751721
Pubmed	Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction.	ATP1A1 ATP1A3	3.45e-05	4	84	2	19376779
Pubmed	Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice.	ATP1A1 ATP1A3	3.45e-05	4	84	2	17234593
Pubmed	Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism.	ATP1A1 ATP1A3	3.45e-05	4	84	2	2887455
Pubmed	Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women.	FZD1 FZD9	5.74e-05	5	84	2	19543507
Pubmed	Multiple genes encode the human Na+,K+-ATPase catalytic subunit.	ATP1A1 ATP1A3	5.74e-05	5	84	2	3035563
Pubmed	A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis.	WRAP53 TERT	5.74e-05	5	84	2	19179534
Pubmed	The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.	ATP1A1 ATP1A3	8.59e-05	6	84	2	3036582
Pubmed	Transport and pharmacological properties of nine different human Na, K-ATPase isozymes.	ATP1A1 ATP1A3	8.59e-05	6	84	2	10636900
Pubmed	Differential involvement of Na(+),K(+)-ATPase isozymes in preimplantation development of the mouse.	ATP1A1 ATP1A3	1.20e-04	7	84	2	10837135
Pubmed	Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice.	ANK1 ATP1A1	1.20e-04	7	84	2	7495297
Pubmed	Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo.	WRAP53 TERT	1.20e-04	7	84	2	20351177
Pubmed	Cryo-EM structure of substrate-bound human telomerase holoenzyme.	WRAP53 TERT	1.20e-04	7	84	2	29695869
Pubmed	Molecular genetics of Na,K-ATPase.	ATP1A1 ATP1A3	1.20e-04	7	84	2	2158121
Pubmed	Expression and distribution of Na, K-ATPase isoforms in the human uterus.	ATP1A1 ATP1A3	1.20e-04	7	84	2	20065300
Pubmed	Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src.	SHC1 ATP1A1	1.20e-04	7	84	2	21278788
Pubmed	Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).	FZD1 FZD9	1.20e-04	7	84	2	15370539
Pubmed	Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit.	ATP1A1 ATP1A3	1.60e-04	8	84	2	19683723
Pubmed	Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse.	ATP1A1 ATP1A3	1.60e-04	8	84	2	2885848
Pubmed	Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis.	FZD1 FZD9	1.60e-04	8	84	2	10559494
Pubmed	Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice.	ATP1A1 ATP1A3	1.60e-04	8	84	2	23652595
Pubmed	Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.	FZD1 FZD9 CELSR3	2.04e-04	47	84	3	33141892
Pubmed	Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain.	AMH ANK1	2.05e-04	9	84	2	7615634
Pubmed	The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm.	ATP1A1 ATP1A3	2.05e-04	9	84	2	15253893
Pubmed	A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.	FZD1 FZD9	2.05e-04	9	84	2	9707618
Pubmed	Expression of Frizzled genes in developing and postnatal hair follicles.	FZD1 FZD9	2.56e-04	10	84	2	15245425
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	MAGI2 TBC1D4 CELSR3 PDZD2	2.85e-04	130	84	4	12421765
Pubmed	Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.	FZD1 FZD9	3.13e-04	11	84	2	24860427
Pubmed	Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.	FZD1 FZD9	3.13e-04	11	84	2	17582687
Pubmed	Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.	FZD1 FZD9	3.13e-04	11	84	2	17576136
Pubmed	Retinal pigment epithelial integrity is compromised in the developing albino mouse retina.	ATP1A1 ATP1A3	3.75e-04	12	84	2	27097562
Pubmed	Accelerated failure time models provide a useful statistical framework for aging research.	SHC1 PAPPA	3.75e-04	12	84	2	19007875
Pubmed	Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.	SHC1 ATP1A1	5.15e-04	14	84	2	16400024
Pubmed	Sequence and expression of murine type I hair keratins mHa2 and mHa3.	STARD9 KIF7	5.15e-04	14	84	2	7514534
Pubmed	Chromosomal assignments of 17 structural genes and 11 related DNA fragments in rats (Rattus norvegicus) by Southern blot analysis of rat x mouse somatic cell hybrid clones.	ATP1A1 ATP1A3	5.15e-04	14	84	2	1572638
Pubmed	Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.	MAGI2 PDZD2	5.93e-04	15	84	2	23782696
Pubmed	Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.	WRAP53 TERT	6.77e-04	16	84	2	25416818
Pubmed	KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.	KDM6B WRAP53	6.77e-04	16	84	2	35212626
Pubmed	Dyskeratosis Congenita and Related Telomere Biology Disorders	WRAP53 TERT	6.77e-04	16	84	2	20301779
Pubmed	The DNA sequence of human chromosome 7.	FZD1 FZD9 MAGI2 FBXO24 ADCK2 COG5	7.09e-04	441	84	6	12853948
Pubmed	PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes.	ATP1A1 ATP1A3	7.66e-04	17	84	2	36230906
Pubmed	TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis.	FZD9 CHSY1	8.60e-04	18	84	2	32924931
Pubmed	Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.	TET1 SAP30L	9.60e-04	19	84	2	22984288
Pubmed	Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.	TET1 SAP30L	9.60e-04	19	84	2	28554894
Pubmed	RNG105 deficiency impairs the dendritic localization of mRNAs for Na+/K+ ATPase subunit isoforms and leads to the degeneration of neuronal networks.	ATP1A1 ATP1A3	9.60e-04	19	84	2	20861386
Pubmed	A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.	TTC31 OSBP2 TREX2 NT5M	9.70e-04	180	84	4	24104479
Pubmed	Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol.	ATP1A1 ATP1A3	1.06e-03	20	84	2	15648052
Pubmed	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	FZD1 FZD9	1.29e-03	22	84	2	17064353
Pubmed	The DNA sequence and comparative analysis of human chromosome 10.	TET1 C10orf95 KAZALD1 MFSD13A PDCD4	1.52e-03	345	84	5	15164054
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	STARD9 KIF7	1.67e-03	25	84	2	9275178
Pubmed	SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.	MAGI2 LRFN5	1.67e-03	25	84	2	27480238
Pubmed	A role for Wnt/beta-catenin signaling in lens epithelial differentiation.	FZD1 FZD9	1.67e-03	25	84	2	12812787
Pubmed	Quantitative trait loci for body size components in mice.	FZD9 FBXO24 KIF7	1.75e-03	98	84	3	16783635
Pubmed	Identification of novel markers of mouse fetal ovary development.	MAGI2 AMH	1.80e-03	26	84	2	22844512
Pubmed	Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.	CHSY1 PAPPA	1.80e-03	26	84	2	33905568
Pubmed	Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections.	FZD1 FZD9	1.95e-03	27	84	2	17804636
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	MAGI2 ARHGAP44 ARHGEF2	1.96e-03	102	84	3	9734811
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP1A1 ATP1A3	2.24e-03	29	84	2	15071553
Pubmed	Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function.	PRSS3 ATP1A1	2.24e-03	29	84	2	34267243
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	FZD1 FZD9	2.24e-03	29	84	2	18364260
Pubmed	Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate.	PRSS27 SIM2	2.24e-03	29	84	2	27120339
Pubmed	Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes.	ATP1A1 ATP1A3	2.40e-03	30	84	2	2842249
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	CDAN1 SPINT1 STARD9 ITPKA	1.60e-04	147	84	4	chr15q15
Cytoband	7q21	FZD1 MAGI2	2.55e-04	13	84	2	7q21
Cytoband	15q15.2	CDAN1 STARD9	3.90e-04	16	84	2	15q15.2
Cytoband	Ensembl 112 genes in cytogenetic band chr10q24	C10orf95 CRTAC1 KAZALD1 MFSD13A	4.15e-04	189	84	4	chr10q24
Cytoband	10q24.32	C10orf95 MFSD13A	8.89e-04	24	84	2	10q24.32
Cytoband	15q15.1	SPINT1 ITPKA	3.39e-03	47	84	2	15q15.1
GeneFamily	ATPase Na+/K+ transporting subunits	ATP1A1 ATP1A3	1.56e-04	7	50	2	1208
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD1 FZD9	4.06e-04	11	50	2	286
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM3B KDM6B	1.99e-03	24	50	2	485
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FZD9 MAGI2 MATN3 CHADL SIM2 BTBD19	8.20e-07	169	84	6	58e22f9119240664515fe91ca53812611a8f17d6
ToppCell	facs-Tongue-nan-18m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS27 KAZALD1 VSIG8 TTC22 PDCD4 ITPKA	1.67e-06	191	84	6	02f24202f9fdd46c648265a5b3b6f9066aa009fc
ToppCell	droplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l14\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AMH TBC1D4 CELSR3 GRIK5 BTBD19	1.03e-05	152	84	5	0fda8980b10ce16179dea92301db74d728f41794
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FZD9 MATN3 KAZALD1 CHADL SIM2	1.35e-05	161	84	5	9703b7e67d9fadb6129cad166bd01be915042e44
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ANK1 CELSR3 KDM6B PDCD4 FCMR	2.26e-05	179	84	5	a28a1de500a74c6dcc43481abf9ec0f7e7a300a9
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAGI2 MATN3 PAPPA RIPOR3 PDZD2	2.26e-05	179	84	5	a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell	18-Airway-RBC\|Airway / Age, Tissue, Lineage and Cell class	CDCA2 TICRR ANK1 RIPOR3 OSBP2	2.32e-05	180	84	5	35bf5f35cf346a5b27f5e819b77db34130d70db1
ToppCell	18-Airway-RBC-RBC\|Airway / Age, Tissue, Lineage and Cell class	CDCA2 TICRR ANK1 RIPOR3 OSBP2	2.32e-05	180	84	5	3b4b220a3c150426ae55239baff756f1a7f1e1d7
ToppCell	Pericytes-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ANK1 LRFN5 MATN3 CACNA1H KIF7	2.38e-05	181	84	5	35c470988a93381eefa300831aabb813fa1b90bd
ToppCell	10x5'-bone_marrow-Hematopoietic_Erythro-Mega-Mega-Mast\|bone_marrow / Manually curated celltypes from each tissue	CDCA2 MAGI2 RIPOR3 GRIK5 ITPKA	2.64e-05	185	84	5	a62ebaff92f2ed27b27b32c27c89cfbe2cb35116
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)\|Thalamus / BrainAtlas - Mouse McCarroll V32	MATN3 RIPOR3 TERT FCMR	2.79e-05	92	84	4	bbaf5a131f860198840e34843b7c841bcc98d9c4
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	MATN3 RIPOR3 TERT FCMR	2.79e-05	92	84	4	e6aa2b8ca9235a7291ee41d976b886fec185835d
ToppCell	COPD-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	CHSY1 KAZALD1 ATP1A1 PDCD4 PDZD2	3.08e-05	191	84	5	ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FZD9 MATN3 CHADL SIM2 PDZD2	3.08e-05	191	84	5	f9a46956778a8773d6656340ecf5d218376d79c2
ToppCell	NS-critical-d_07-13-Epithelial-Squamous\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PRSS3 SPINT1 PRSS27 TTC22 SIM2	3.32e-05	194	84	5	53a34843d529ef395deb27086f71f7049a087bab
ToppCell	facs-Trachea-nan-3m-Mesenchymal-chondrocyte\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD9 MATN3 LTBP3 CHADL SIM2	3.65e-05	198	84	5	71e847e8c24744d6df4a960348ad2ecf310373b4
Drug	Gelsemine [509-15-9]; Down 200; 12.4uM; PC3; HT_HG-U133A	AMH OSBP2 KAZALD1 GRIK5 ATP1A3 WRAP53 MFSD13A	7.77e-06	197	83	7	4097_DN
Drug	Alprostadil [745-65-3]; Down 200; 11.2uM; MCF7; HT_HG-U133A	OXLD1 C10orf95 ADCK2 KAZALD1 SIM2 KDM6B FCMR	7.77e-06	197	83	7	7358_DN
Drug	Methocarbamol [532-03-6]; Up 200; 16.6uM; PC3; HT_HG-U133A	CELSR3 YTHDC2 TTC22 KDM6B MFSD13A NT5M FCMR	8.03e-06	198	83	7	2111_UP
Drug	Acetopromazine maleate salt [3598-37-6]; Up 200; 9uM; PC3; HT_HG-U133A	MAGI2 IRS4 CELSR3 ZMAT4 GRIK5 ATP1A3 KDM6B	8.30e-06	199	83	7	4494_UP
Drug	Ald1.1-H_000455; Down 200; 10uM; PC3; HT_HG-U133A	FZD1 EPM2A SIGLEC8 ZNF74 KAZALD1 WRAP53 MFSD13A	8.30e-06	199	83	7	7547_DN
Drug	wortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT_HG-U133A	ANK1 CACNA1H KAZALD1 NAGPA PDCD4 FCMR	7.12e-05	191	83	6	6959_UP
Drug	Pyrantel tartrate [33401-94-4]; Up 200; 11.2uM; MCF7; HT_HG-U133A	FZD1 FZD9 MAGI2 C10orf95 OSBP2 NT5M	7.98e-05	195	83	6	2260_UP
Drug	Spaglumic acid [4910-46-7]; Down 200; 13.2uM; HL60; HT_HG-U133A	FZD1 DISC1 ADCK2 KDM6B WRAP53 NT5M	7.98e-05	195	83	6	2962_DN
Drug	(cis-) Nanophine [5072-45-7]; Up 200; 26.8uM; MCF7; HT_HG-U133A	PRSS3 GRK6 ZMAT4 GRIK5 SIM2 FCMR	8.21e-05	196	83	6	3889_UP
Drug	Retrorsine [480-54-6]; Up 200; 11.4uM; PC3; HT_HG-U133A	HABP4 EPM2A SIGLEC8 ZNF74 GRIK5 MFSD13A	8.21e-05	196	83	6	6601_UP
Drug	Pentolinium bitartrate [52-62-0]; Up 200; 7.4uM; MCF7; HT_HG-U133A	ZNF74 C10orf95 OSBP2 KAZALD1 GRIK5 ATP1A3	8.21e-05	196	83	6	4699_UP
Drug	Bretylium tosylate [61-75-6]; Up 200; 9.6uM; MCF7; HT_HG-U133A	EPM2A SIGLEC8 DISC1 CACNA1H GRIK5 ARHGEF2	8.21e-05	196	83	6	3394_UP
Drug	ICI182,780; Down 200; 1uM; PC3; HT_HG-U133A	AMH HABP4 EPM2A CELSR3 ARHGEF2 FCMR	8.21e-05	196	83	6	7495_DN
Drug	AG-013608 [351320-38-2]; Up 200; 10uM; PC3; HT_HG-U133A	GRK6 ZNF74 ADCK2 GRIK5 KDM6B MFSD13A	8.44e-05	197	83	6	6440_UP
Drug	Benfotiamine [22457-89-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A	AMH DISC1 C10orf95 ZMAT4 KAZALD1 PDCD4	8.44e-05	197	83	6	3837_DN
Drug	Catechin-(+,-) hydrate [7295-85-4]; Up 200; 13.8uM; MCF7; HT_HG-U133A	ANK1 SIGLEC8 YTHDC2 ARHGEF2 TBC1D29P FCMR	8.44e-05	197	83	6	3351_UP
Drug	Hydroflumethiazide [135-09-1]; Up 200; 12uM; PC3; HT_HG-U133A	AMH HABP4 EPM2A SIGLEC8 YTHDC2 KDM6B	8.44e-05	197	83	6	7259_UP
Drug	Dioxybenzone [131-53-3]; Down 200; 16.4uM; PC3; HT_HG-U133A	AMH CELSR3 SIGLEC8 KAZALD1 ATP1A3 PDCD4	8.44e-05	197	83	6	4638_DN
Drug	Isoniazid [54-85-3]; Up 200; 29.2uM; MCF7; HT_HG-U133A	EPM2A SIGLEC8 MATN3 TTC22 SIM2 NT5M	8.68e-05	198	83	6	2246_UP
Drug	Ketorolac tromethamine [74103-07-4]; Up 200; 10.6uM; MCF7; HT_HG-U133A	SIGLEC8 ZNF74 PAPPA KAZALD1 SIM2 FCMR	8.68e-05	198	83	6	5988_UP
Drug	Cisapride [81098-60-4]; Up 200; 8.6uM; PC3; HT_HG-U133A	SIGLEC8 ZMAT4 TTC22 KDM6B MFSD13A FCMR	8.68e-05	198	83	6	6706_UP
Drug	Triflusal [322-79-2]; Up 200; 16.2uM; MCF7; HT_HG-U133A	MAGI2 IRS4 SIGLEC8 C10orf95 CACNA1H FCMR	8.68e-05	198	83	6	2867_UP
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; MCF7; HT_HG-U133A	DISC1 CACNA1H KAZALD1 GRIK5 SIM2 FCMR	8.68e-05	198	83	6	6031_DN
Drug	Natamycin [7681-93-8]; Up 200; 6uM; MCF7; HT_HG-U133A	IRS4 ANK1 C10orf95 CRTAC1 ATP1A3 PDCD4	8.68e-05	198	83	6	3548_UP
Drug	Ethotoin [86-35-1]; Up 200; 19.6uM; MCF7; HT_HG-U133A	SIGLEC8 CRTAC1 GRIK5 SIM2 TBC1D29P TERT	8.68e-05	198	83	6	3892_UP
Drug	clozapine; Up 200; 10uM; PC3; HT_HG-U133A	AMH GRK6 ZNF74 OSBP2 KAZALD1 FCMR	8.92e-05	199	83	6	1229_UP
Drug	Rilmenidine hemifumarate [54187-04-1]; Up 200; 8.4uM; HL60; HT_HG-U133A	IRS4 CELSR3 C10orf95 YTHDC2 NAGPA ITPKA	8.92e-05	199	83	6	3133_UP
Drug	Oxolinic acid [14698-29-4]; Up 200; 15.4uM; PC3; HT_HG-U133A	FZD1 DISC1 GRIK5 KDM6B PDCD4 FCMR	8.92e-05	199	83	6	5094_UP
Disease	bipolar disorder (is_implicated_in)	DISC1 GCH1 ATP1A3	5.72e-05	29	76	3	DOID:3312 (is_implicated_in)
Disease	familial hemiplegic migraine (implicated_via_orthology)	ATP1A1 ATP1A3	1.36e-04	7	76	2	DOID:0060178 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	GRK6 KDM3B ATP1A1 ATP1A3 KDM6B	1.51e-04	195	76	5	DOID:1574 (implicated_via_orthology)
Disease	colorectal cancer	MAGI2 ANK1 RIPOR3 OSBP2 GRIK5 TTC22 TERT PDZD2	1.63e-04	604	76	8	MONDO_0005575
Disease	Dyskeratosis congenita	WRAP53 TERT	2.33e-04	9	76	2	cv:C0265965
Disease	abdominal adipose tissue measurement	CDCA2 ATP1A1 ATP1A3	3.51e-04	53	76	3	EFO_0803316
Disease	nervous system disease (implicated_via_orthology)	ATP1A1 ATP1A3	4.25e-04	12	76	2	DOID:863 (implicated_via_orthology)
Disease	glucagon measurement	ZNF469 SLC35F3 ATP1A1 ATP1A3	6.84e-04	154	76	4	EFO_0008463
Disease	Dyskeratosis Congenita	WRAP53 TERT	7.67e-04	16	76	2	C0265965
Disease	eicosapentaenoate EPA; 20:5n3 measurement	FZD1 GRIK5	8.68e-04	17	76	2	EFO_0021049
Disease	Dystonia, Limb	GCH1 ATP1A3	8.68e-04	17	76	2	C0751093
Disease	Dystonia, Diurnal	GCH1 ATP1A3	8.68e-04	17	76	2	C0393610
Disease	Dystonia, Paroxysmal	GCH1 ATP1A3	9.75e-04	18	76	2	C0393588
Disease	Osteoarthritis of hip	LTBP3 CHADL	1.21e-03	20	76	2	C0029410
Disease	breast cancer (is_marker_for)	AMH SPINT1 KDM3B WRAP53	1.35e-03	185	76	4	DOID:1612 (is_marker_for)
Disease	Bipolar Disorder	MAGI2 STARD9 DISC1 GRIK5 ATP1A1 ATP1A3	1.46e-03	477	76	6	C0005586
Disease	Anhedonia	DISC1 ATP1A3	1.74e-03	24	76	2	C0178417
Disease	aspartate measurement	GRK6 COG5	1.74e-03	24	76	2	EFO_0010462
Disease	carnosine measurement	GRIK5 COG5	1.74e-03	24	76	2	EFO_0010470
Disease	Degenerative polyarthritis	MATN3 LTBP3 ATP1A3	1.80e-03	93	76	3	C0029408
Disease	Osteoarthrosis Deformans	MATN3 LTBP3 ATP1A3	1.80e-03	93	76	3	C0086743
Disease	taurine measurement	SLC35F3 GRK6	2.04e-03	26	76	2	EFO_0010536
Disease	sleep duration	MAGI2 ANK1 KDM3B COG5 PDZD2	2.45e-03	362	76	5	EFO_0005271

Protein segments in the cluster

Peptide	Gene	Start	Entry
GRCAIHPRRSKGADL	CEP295NL	236	Q96MC4
VAARAGALGAARCRP	EPM2A	76	B3EWF7
ASVGVCRRKAEAGAG	AMER2	21	Q8N7J2
CRRKAEAGAGTGTLA	AMER2	26	Q8N7J2
SRRRVRCSGAAGAGP	ADCK2	66	Q7Z695
KLCRANSRDGEAGRA	ARHGEF2	776	Q92974
CAKGSGAEDRRRTPT	ANK1	1366	P16157
RRGRPRASCGAQKEH	C20orf204	81	A0A1B0GTL2
RPDDGALRKRCGSRD	C1QTNF12	81	Q5T7M4
EAACSDGARRVRAAG	DISC1	161	Q9NRI5
ALGREFCQRKSPGAV	CDAN1	931	Q8IWY9
GQRATLRCKARGDPE	LRFN5	301	Q96NI6
CAAPRGCLAGRVRDA	KAZALD1	61	Q96I82
SEPGRARGAGVCKSR	MATN3	66	O15232
KEAPRAAAGSELCRR	MAGI2	1366	Q86UL8
RAAVPDAVGKCRSAG	ATP1A1	596	P05023
EAGGVAAVSGSCKRR	KDM6B	961	O15054
KRRDEAAAAAGAGPR	HABP4	56	Q5JVS0
LCPSRGRKRFVSEGD	PDCD4	446	Q53EL6
PACGAGRSKGRTRRE	NUPR2	41	A6NF83
KCRAEGRAPRADSGP	PDZD2	2021	O15018
RGGEKRSLCSEGRQA	KIF7	1221	Q2M1P5
GKDGRRRKSASDSGC	KDM3B	281	Q7LBC6
RSAGATAADGPCALR	AMH	451	P03971
AAGPATCATRAARGR	PAPPA	41	Q13219
SRRRRLEACGPGSSC	OSBP2	851	Q969R2
AVRGSGARRFSSPDC	OXLD1	16	Q5BKU9
RCAAVAAAAAAGEPR	ITPKA	41	P23677
AAAAAAGEPRARGAK	ITPKA	46	P23677
KGLDARAVCVGRAPR	PFN3	91	P60673
KCHALRRGDEARGAP	BTBD19	256	C9JJ37
KVCGASAGRRDAARP	LINC00472	61	Q9H8W2
AVGPFCRRVSDLGKS	COG5	711	Q9UP83
AGASERGKFSCPRAL	FZD1	266	Q9UP38
AAGRARAKACRAPGS	FZD9	546	O00144
RASGRRACCGRAVPL	POLR2M	121	Q6EEV4
RCVCKAGFARSRPHG	LTBP3	1281	Q9NS15
AFGGRRRCLSKSVAP	FBXO24	116	O75426
KCRRRSAVGARGSPE	CDCA2	86	Q69YH5
RAAVPDAVGKCRSAG	ATP1A3	586	P13637
RACAARGAAVAKVGQ	HAPLN4	291	Q86UW8
RGRKQRRPSASCTFG	LINC01560	21	Q8TB33
AGRSVACVDRKGSGR	CRTAC1	176	Q9NQ79
ARARVRSDGACQGPR	CHADL	326	Q6NUI6
AGTGSRKRVGTARCC	CELSR3	191	Q9NYQ7
CRRIQALRASGAGAP	GRIK5	936	Q16478
KDPAERLGCRGGSAR	GRK6	426	P43250
APSLKRRGQCGERES	CACNA1H	1151	O95180
AACGPASDRFGRRLV	SLC22A12	161	Q96S37
RRVEAARKDPGCSGL	MFSD13A	216	Q14CX5
SKRRRCGTLGAQPDG	IRS4	201	O14654
RLCSAAVPAGRRGAA	NT5M	11	Q9NPB1
PAGSARAALARCADG	RSBN1	21	Q5VWQ0
ARPGRDCEVRATFAK	WRAP53	306	Q9BUR4
VRAPAEKPRGARCSN	GCH1	6	P30793
GPGGCAARRRATVEE	NAGPA	111	Q9UK23
GPAKAARQAARDGAR	SIM2	556	Q14190
SCRKKSARPAAGVGD	SIGLEC8	386	Q9NYZ4
GQPCTARAALARKGA	STARD9	901	Q9P2P6
ARRGSSAGRKVSCAP	ARHGAP44	526	Q17R89
APAGVEAGGRASRRC	SLC35F3	41	Q8IY50
RECRLGSKEGRPFSG	TET1	1646	Q8NFU7
RRASPEGCRSGQAAA	CHSY1	41	Q86X52
AATKCGEEPRSGSRR	C10orf95	6	Q9H7T3
RRGRRAGACKPSCAG	C10orf95	156	Q9H7T3
APRAACARAKPASRA	PRDM10-DT	66	Q96N53
CPERTGGDAATRSAR	nan	46	P0C880
CTEARAGRGGPATAR	nan	61	Q96NJ1
DAVAPGCKASGRGSR	VSIG8	326	P0DPA2
PRRKRAVGCGAGSSS	TICRR	1686	Q7Z2Z1
SGSRGDALNLRCPKR	ZSCAN5DP	281	P0CG00
GTPRVCRAASARLAG	RIPOR3	831	Q96MK2
GSQRAKAATACGRPR	PRSS27	16	Q9BQR3
ERCVRPAGNASFSKR	SAP30L	36	Q9HAJ7
LASNKVGRCRGSFPR	SPINT1	251	O43278
SACPRRARGADAAGT	FCMR	316	O60667
VSLAAPKRCAGRFSG	YJEFN3	251	A6XGL0
RALKGTGRARPICES	TBC1D29P	76	Q9UFV1
EIRRRSQKPEAGGCG	TBC1D4	61	O60343
RQGGAGSAVKCRRDS	nan	111	Q8N1X5
VFSGKRRAPGARGRC	ZNF469	3591	Q96JG9
CGKGLAAARPGRVER	PRSS3	21	P35030
ASAIQRKGRAGRCRP	YTHDC2	731	Q9H6S0
ATEGRTKAPARLCAG	ZNF74	206	Q16587
ARCRKAGFDGAVVRT	TREX2	86	Q9BQ50
VGCASPEERARGLAA	TTC22	161	Q5TAA0
RDGGCPAKRLRSENG	ZMAT4	51	Q9H898
CEAVPGAKGATRRRK	SHC1	196	P29353
RAAVTPAAGVCAREK	TERT	416	O14746
RGGSQPDAARELRSC	TTC31	401	Q49AM3