Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncytoskeletal protein binding

TTLL12 MYO10 AXL CAMK2B FARP1 TLN1 SPTB UNC5C TUBGCP3 KIF19 DIAPH2 FXYD5 DLG4 SKA1 PLS1 HNRNPU SNX5 CHP1

1.63e-0610999018GO:0008092
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

KRT16 CAMK2B TLN1 SPTB TUBGCP3 MYOM2 PLS1

2.01e-06130907GO:0005200
GeneOntologyMolecularFunctionphosphatidylserine binding

SYT3 AXL TLN1 SYT9 SYT10

1.96e-0573905GO:0001786
GeneOntologyMolecularFunctionendoribonuclease activity, cleaving miRNA-paired mRNA

AGO2 AGO3

2.01e-052902GO:0090624
GeneOntologyMolecularFunctionFMN binding

POR MTRR NDUFV1

4.75e-0516903GO:0010181
GeneOntologyMolecularFunctionprotein kinase activity

JAK2 TLK1 AXL CAMK2B CSNK2A1 BTK PRKG1 CSNK2A3 ZAP70 WNK2 CHUK

7.97e-056009011GO:0004672
GeneOntologyMolecularFunctionkinase binding

JAK2 CAB39 CCNYL1 CAMK2B UNC5C SPDYE2 UGT1A9 DLG4 MYOM2 PRKG1 SPDYE2B LYST SPDYE6 CHP1

1.06e-049699014GO:0019900
GeneOntologyMolecularFunctionNADPH-hemoprotein reductase activity

POR MTRR

1.99e-045902GO:0003958
GeneOntologyMolecularFunctionmodified amino acid binding

SYT3 AXL TLN1 SYT9 SYT10

2.28e-04122905GO:0072341
GeneOntologyMolecularFunctionacetylcholine receptor regulator activity

SPDYE2 SPDYE2B SPDYE6

2.39e-0427903GO:0030548
GeneOntologyMolecularFunctionneurotransmitter receptor regulator activity

SPDYE2 SPDYE2B SPDYE6

2.67e-0428903GO:0099602
GeneOntologyMolecularFunctionphosphatidylinositol phosphate binding

SYT3 MYO10 BTK SYT9 SYT10 SNX5

2.82e-04199906GO:1901981
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

JAK2 TLK1 AXL CAMK2B CSNK2A1 BTK PRKG1 CSNK2A3 ZAP70 WNK2 CHUK

3.40e-047099011GO:0016773
GeneOntologyMolecularFunctionRNA nuclease activity

AGO2 AGO4 AGO3 PAN2 TSNAX

3.76e-04136905GO:0004540
GeneOntologyMolecularFunctiondouble-stranded RNA binding

AGO2 AGO4 AGO3 HNRNPU

4.27e-0478904GO:0003725
GeneOntologyMolecularFunctionRNA endonuclease activity

AGO2 AGO4 AGO3 TSNAX

4.48e-0479904GO:0004521
GeneOntologyMolecularFunctioncalcium ion binding

CAB39 SYT3 ENPP1 FSTL5 SLC25A13 SYT9 SYT10 PLS1 RHOT1 CHP1 STAB1

5.39e-047499011GO:0005509
GeneOntologyMolecularFunctionphosphatidylinositol binding

SYT3 MYO10 TLN1 BTK SYT9 SYT10 SNX5

5.66e-04316907GO:0035091
GeneOntologyMolecularFunctionnuclease activity

AGO2 AGO4 AGO3 ENPP1 PAN2 TSNAX

6.23e-04231906GO:0004518
GeneOntologyMolecularFunctionkinase activity

JAK2 TLK1 AXL CAMK2B CSNK2A1 BTK PRKG1 CSNK2A3 ZAP70 WNK2 CHUK

6.35e-047649011GO:0016301
GeneOntologyMolecularFunctionnon-membrane spanning protein tyrosine kinase activity

JAK2 BTK ZAP70

1.17e-0346903GO:0004715
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

POR MTRR

1.29e-0312902GO:0016653
GeneOntologyMolecularFunctionmiRNA binding

AGO2 AGO4 AGO3

1.32e-0348903GO:0035198
GeneOntologyMolecularFunctionactin binding

MYO10 CAMK2B TLN1 SPTB DIAPH2 FXYD5 PLS1 HNRNPU

1.44e-03479908GO:0003779
GeneOntologyMolecularFunctionsingle-stranded RNA binding

AGO2 AGO4 AGO3 HNRNPU

1.60e-03111904GO:0003727
GeneOntologyMolecularFunctionD1 dopamine receptor binding

DLG4 SNX5

1.76e-0314902GO:0031748
GeneOntologyMolecularFunctionprotein kinase binding

JAK2 CCNYL1 CAMK2B UNC5C SPDYE2 UGT1A9 DLG4 PRKG1 SPDYE2B LYST SPDYE6

1.86e-038739011GO:0019901
GeneOntologyMolecularFunctionHsp90 protein binding

AGO2 CYP2E1 CSNK2A1

1.96e-0355903GO:0051879
GeneOntologyMolecularFunctionpotassium channel regulator activity

FXYD5 WNK2 CHP1

2.17e-0357903GO:0015459
GeneOntologyMolecularFunctionphosphatidylinositol bisphosphate binding

SYT3 SYT9 SYT10 SNX5

2.19e-03121904GO:1902936
GeneOntologyMolecularFunctionacetylcholine receptor binding

JAK2 DLG4

2.31e-0316902GO:0033130
GeneOntologyMolecularFunctionelectron transfer activity

P4HA2 POR ME1 NDUFV1

2.40e-03124904GO:0009055
GeneOntologyMolecularFunctioncalcium-dependent phospholipid binding

SYT3 SYT9 SYT10

2.52e-0360903GO:0005544
GeneOntologyMolecularFunctionNADP binding

POR MTRR ME1

2.76e-0362903GO:0050661
GeneOntologyMolecularFunctionregulatory RNA binding

AGO2 AGO4 AGO3

2.76e-0362903GO:0061980
GeneOntologyMolecularFunctionclathrin binding

SYT3 SYT9 SYT10

2.89e-0363903GO:0030276
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

JAK2 TLK1 AXL CAMK2B CSNK2A1 BTK PRKG1 CSNK2A3 ZAP70 WNK2 CHUK

3.25e-039389011GO:0016772
GeneOntologyMolecularFunctionphospholipid binding

SYT3 MYO10 AXL TLN1 BTK SYT9 SYT10 SNX5

3.30e-03548908GO:0005543
GeneOntologyMolecularFunctionendonuclease activity

AGO2 AGO4 AGO3 TSNAX

3.35e-03136904GO:0004519
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

TLK1 CAMK2B CSNK2A1 PRKG1 CSNK2A3 WNK2 CHUK

4.02e-03446907GO:0004674
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

JAK2 AXL BTK ZAP70

4.21e-03145904GO:0004713
GeneOntologyBiologicalProcesssiRNA-mediated post-transcriptional gene silencing

AGO2 AGO4 AGO3

3.10e-074893GO:0140766
GeneOntologyBiologicalProcesssiRNA-mediated gene silencing by mRNA destabilization

AGO2 AGO4 AGO3

3.10e-074893GO:0090625
GeneOntologyBiologicalProcessRNA secondary structure unwinding

AGO2 AGO4 AGO3

6.40e-069893GO:0010501
GeneOntologyBiologicalProcessRISC complex assembly

AGO2 AGO4 AGO3

9.12e-0610893GO:0070922
GeneOntologyBiologicalProcesspre-miRNA processing

AGO2 AGO4 AGO3

5.05e-0517893GO:0031054
GeneOntologyBiologicalProcessprotein autophosphorylation

JAK2 ENPP1 CAMK2B CSNK2A1 ZAP70 WNK2 CHP1

5.87e-05228897GO:0046777
GeneOntologyBiologicalProcesspositive regulation of molecular function

JAK2 CAB39 RTKN2 AXL DOCK9 BTK SPDYE2 POR DLG4 SPDYE2B VAV1 WNK2 STAT1 SPDYE6 HNRNPU CHUK CHP1

1.15e-0414308917GO:0044093
GeneOntologyBiologicalProcessregulation of body fluid levels

JAK2 AXL ENPP1 TLN1 SERPINC1 PRKG1 LYST VAV1 CHUK

1.23e-04442899GO:0050878
GeneOntologyBiologicalProcessblood coagulation

JAK2 AXL TLN1 SERPINC1 PRKG1 LYST VAV1

1.33e-04260897GO:0007596
GeneOntologyBiologicalProcesscoagulation

JAK2 AXL TLN1 SERPINC1 PRKG1 LYST VAV1

1.53e-04266897GO:0050817
GeneOntologyBiologicalProcesshemostasis

JAK2 AXL TLN1 SERPINC1 PRKG1 LYST VAV1

1.61e-04268897GO:0007599
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE2 SPDYE2B SPDYE6

1.67e-0425893GO:0045737
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein kinase activity

SPDYE2 SPDYE2B SPDYE6

2.35e-0428893GO:1904031
GeneOntologyCellularComponentRISC-loading complex

AGO2 AGO4 AGO3

9.06e-0610903GO:0070578
GeneOntologyCellularComponentcytoplasmic side of plasma membrane

JAK2 FARP1 SPTB DLG4 ZAP70 SNX5 CHUK

1.53e-05185907GO:0009898
GeneOntologyCellularComponentendoribonuclease complex

AGO2 AGO4 AGO3 TSNAX

1.90e-0537904GO:1902555
GeneOntologyCellularComponentendonuclease complex

AGO2 AGO4 AGO3 TSNAX

3.49e-0543904GO:1905348
GeneOntologyCellularComponentcytoplasmic side of membrane

JAK2 FARP1 SPTB DLG4 ZAP70 SNX5 CHUK

6.13e-05230907GO:0098562
GeneOntologyCellularComponentprotein kinase CK2 complex

CSNK2A1 CSNK2A3

1.09e-044902GO:0005956
GeneOntologyCellularComponentP-body

AGO2 AGO4 AGO3 PAN2

9.90e-04102904GO:0000932
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

AGO2 AGO4 AGO3 PAN2 ZNFX1 HNRNPU

1.08e-03269906GO:0036464
GeneOntologyCellularComponentribonucleoprotein granule

AGO2 AGO4 AGO3 PAN2 ZNFX1 HNRNPU

1.51e-03287906GO:0035770
DomainArgonaute_N

AGO2 AGO4 AGO3

4.03e-074883IPR032474
DomainArgonaute_Mid_dom

AGO2 AGO4 AGO3

4.03e-074883IPR032473
DomainArgoL2

AGO2 AGO4 AGO3

4.03e-074883IPR032472
DomainArgoN

AGO2 AGO4 AGO3

4.03e-074883PF16486
DomainArgoMid

AGO2 AGO4 AGO3

4.03e-074883PF16487
DomainArgoL2

AGO2 AGO4 AGO3

4.03e-074883PF16488
DomainDUF1785

AGO2 AGO4 AGO3

1.00e-065883SM01163
DomainArgoL1

AGO2 AGO4 AGO3

2.00e-066883PF08699
DomainArgoL1

AGO2 AGO4 AGO3

2.00e-066883IPR014811
DomainPIWI

AGO2 AGO4 AGO3

5.56e-068883PS50822
DomainPiwi

AGO2 AGO4 AGO3

5.56e-068883SM00950
DomainPiwi

AGO2 AGO4 AGO3

5.56e-068883IPR003165
DomainPiwi

AGO2 AGO4 AGO3

5.56e-068883PF02171
DomainPAZ

AGO2 AGO4 AGO3

8.32e-069883PS50821
DomainPAZ

AGO2 AGO4 AGO3

8.32e-069883SM00949
DomainPAZ_dom

AGO2 AGO4 AGO3

8.32e-069883IPR003100
DomainPAZ

AGO2 AGO4 AGO3

8.32e-069883PF02170
DomainPROTEIN_KINASE_ATP

JAK2 TLK1 AXL CAMK2B CSNK2A1 BTK PRKG1 CSNK2A3 ZAP70 WNK2 CHUK

1.02e-054598811PS00107
DomainProtein_kinase_ATP_BS

JAK2 TLK1 AXL CAMK2B CSNK2A1 BTK PRKG1 CSNK2A3 ZAP70 CHUK

1.16e-053798810IPR017441
DomainSpy1

SPDYE2 SPDYE2B SPDYE6

1.62e-0511883PF11357
DomainSpeedy

SPDYE2 SPDYE2B SPDYE6

1.62e-0511883IPR020984
DomainProt_kinase_dom

JAK2 TLK1 AXL CAMK2B CSNK2A1 BTK PRKG1 CSNK2A3 ZAP70 WNK2 CHUK

1.84e-054898811IPR000719
DomainPROTEIN_KINASE_DOM

JAK2 TLK1 AXL CAMK2B CSNK2A1 BTK PRKG1 CSNK2A3 ZAP70 WNK2 CHUK

1.98e-054938811PS50011
DomainPH_dom-like

JAK2 RTKN2 MYO10 FARP1 DOCK9 TLN1 BTK PLEKHA2 LYST VAV1

3.17e-054268810IPR011993
DomainKinase-like_dom

JAK2 TLK1 AXL CAMK2B CSNK2A1 BTK PRKG1 CSNK2A3 ZAP70 WNK2 CHUK

4.72e-055428811IPR011009
Domain-

AGO2 AGO4 AGO3 PAN2

7.03e-05478843.30.420.10
DomainFERM_central

JAK2 MYO10 FARP1 TLN1

8.29e-0549884IPR019748
DomainFERM_domain

JAK2 MYO10 FARP1 TLN1

8.29e-0549884IPR000299
DomainFERM_1

JAK2 MYO10 FARP1 TLN1

8.98e-0550884PS00660
DomainFERM_2

JAK2 MYO10 FARP1 TLN1

8.98e-0550884PS00661
DomainFERM_3

JAK2 MYO10 FARP1 TLN1

8.98e-0550884PS50057
DomainBand_41_domain

JAK2 MYO10 FARP1 TLN1

8.98e-0550884IPR019749
DomainB41

JAK2 MYO10 FARP1 TLN1

8.98e-0550884SM00295
DomainPH

RTKN2 MYO10 FARP1 DOCK9 BTK PLEKHA2 VAV1

1.04e-04229887PF00169
DomainSynaptotagmin

SYT3 SYT9 SYT10

1.09e-0420883IPR001565
DomainSH2

JAK2 BTK ZAP70 VAV1 STAT1

1.15e-04101885PF00017
DomainSH2

JAK2 BTK ZAP70 VAV1 STAT1

1.72e-04110885SM00252
DomainSH2

JAK2 BTK ZAP70 VAV1 STAT1

1.79e-04111885PS50001
DomainSH2

JAK2 BTK ZAP70 VAV1 STAT1

1.87e-04112885IPR000980
Domain-

JAK2 BTK ZAP70 VAV1 STAT1

1.87e-041128853.30.505.10
DomainRNaseH-like_dom

AGO2 AGO4 AGO3 PAN2

3.15e-0469884IPR012337
DomainFAD_binding_1

POR MTRR

3.25e-046882PF00667
DomainFAD-binding_1

POR MTRR

3.25e-046882IPR003097
Domain-

POR MTRR

3.25e-0468821.20.990.10
DomainNADPH_Cyt_P450_Rdtase_dom3

POR MTRR

3.25e-046882IPR023173
DomainPH

RTKN2 MYO10 FARP1 DOCK9 BTK PLEKHA2 VAV1

3.41e-04278887SM00233
DomainPH_DOMAIN

RTKN2 MYO10 FARP1 DOCK9 BTK PLEKHA2 VAV1

3.48e-04279887PS50003
DomainPH_domain

RTKN2 MYO10 FARP1 DOCK9 BTK PLEKHA2 VAV1

3.56e-04280887IPR001849
Domain-

RTKN2 MYO10 FARP1 DOCK9 TLN1 BTK PLEKHA2 VAV1

5.13e-043918882.30.29.30
DomainFLAVODOXIN_LIKE

POR MTRR

6.03e-048882PS50902
DomainFlavodoxin/NO_synth

POR MTRR

6.03e-048882IPR008254
DomainFlavdoxin-like

POR MTRR

6.03e-048882IPR001094
DomainFlavodoxin_1

POR MTRR

6.03e-048882PF00258
DomainEF-hand_1

FSTL5 SLC25A13 PLS1 RHOT1 CHP1

7.61e-04152885PF00036
DomainTyrKc

JAK2 AXL BTK ZAP70

7.94e-0488884SM00219
DomainTyr_kinase_cat_dom

JAK2 AXL BTK ZAP70

7.94e-0488884IPR020635
DomainFlavoprotein-like_dom

POR MTRR

9.64e-0410882IPR029039
DomainFlavoprot_Pyr_Nucl_cyt_Rdtase

POR MTRR

9.64e-0410882IPR001709
Domain-

POR MTRR

9.64e-04108823.40.50.360
DomainPROTEIN_KINASE_TYR

JAK2 AXL BTK ZAP70

1.14e-0397884PS00109
DomainTyr_kinase_AS

JAK2 AXL BTK ZAP70

1.14e-0397884IPR008266
DomainFERM_M

MYO10 FARP1 TLN1

1.33e-0346883PF00373
DomainOxRdtase_FAD/NAD-bd

POR MTRR

1.40e-0312882IPR001433
DomainNAD_binding_1

POR MTRR

1.40e-0312882PF00175
Domain-

FSTL5 SLC25A13 PLS1 STAT1 RHOT1 CHP1

1.46e-032618861.10.238.10
DomainSer/Thr_kinase_AS

TLK1 CAMK2B CSNK2A1 PRKG1 CSNK2A3 WNK2 CHUK

1.48e-03357887IPR008271
DomainS_TKc

TLK1 CAMK2B CSNK2A1 PRKG1 CSNK2A3 WNK2 CHUK

1.53e-03359887SM00220
Domain-

MYO10 FARP1 TLN1

1.59e-03498831.20.80.10
DomainPROTEIN_KINASE_ST

TLK1 CAMK2B CSNK2A1 PRKG1 CSNK2A3 WNK2 CHUK

1.60e-03362887PS00108
DomainFERM/acyl-CoA-bd_prot_3-hlx

MYO10 FARP1 TLN1

1.69e-0350883IPR014352
DomainPkinase

TLK1 CAMK2B CSNK2A1 PRKG1 CSNK2A3 WNK2 CHUK

2.14e-03381887PF00069
DomainEF-hand-dom_pair

FSTL5 SLC25A13 PLS1 STAT1 RHOT1 CHP1

2.36e-03287886IPR011992
DomainEF_HAND_1

FSTL5 SLC25A13 PLS1 RHOT1 CHP1

2.78e-03204885PS00018
DomainPkinase_Tyr

JAK2 AXL BTK ZAP70

3.24e-03129884PF07714
DomainFd_Rdtase_FAD-bd

POR MTRR

3.56e-0319882IPR017927
DomainFAD_FR

POR MTRR

3.56e-0319882PS51384
DomainRiboflavin_synthase-like_b-brl

POR MTRR

3.56e-0319882IPR017938
DomainCH

SPTB PLS1 VAV1

3.58e-0365883SM00033
DomainSer-Thr/Tyr_kinase_cat_dom

JAK2 AXL BTK ZAP70

4.12e-03138884IPR001245
DomainCH

SPTB PLS1 VAV1

4.41e-0370883PF00307
Domain-

SPTB PLS1 VAV1

4.59e-03718831.10.418.10
PathwayREACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS

AGO2 AGO4 AGO3 TSNAX

4.31e-088724MM15082
PathwayREACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS

AGO2 AGO4 AGO3 TSNAX

7.73e-089724M27340
PathwayBIOCARTA_DICER_PATHWAY

AGO2 AGO4 AGO3

1.27e-065723M22079
PathwayREACTOME_MICRORNA_MIRNA_BIOGENESIS

AGO2 AGO4 AGO3

2.53e-066723MM14818
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

AGO2 AGO4 AGO3

2.53e-066723MM15083
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

AGO2 AGO4 AGO3

4.41e-067723M46421
PathwayREACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION

AGO2 AGO4 AGO3

1.05e-059723M27810
PathwayREACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION

AGO2 AGO4 AGO3

1.05e-059723M46436
PathwayREACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS

AGO2 AGO4 AGO3

1.49e-0510723M48013
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

AGO2 AGO4 AGO3 CAMK2B

2.02e-0532724M27900
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

AGO2 AGO4 AGO3 SYT10

2.58e-0534724M46422
PathwayREACTOME_NUCLEAR_EVENTS_STIMULATED_BY_ALK_SIGNALING_IN_CANCER

AGO2 AGO4 AGO3 ZAP70

2.91e-0535724M42525
PathwayREACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION

AGO2 AGO4 AGO3

3.52e-0513723M46434
PathwayREACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY

AGO2 AGO4 AGO3

8.25e-0517723M27788
PathwayREACTOME_SIGNALING_BY_ALK_IN_CANCER

AGO2 AGO4 AGO3 ZAP70 STAT1

1.11e-0493725M42521
PathwayREACTOME_GENE_SILENCING_BY_RNA

AGO2 AGO4 AGO3 TSNAX

1.11e-0449724MM14837
PathwayREACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS

JAK2 AGO2 AGO4 AGO3 CAMK2B TLN1 ZAP70 VAV1 STAT1 CHUK

1.17e-044647210M27547
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS

AGO2 AGO4 AGO3

1.17e-0419723M48238
PathwayWP_KIT_RECEPTOR_SIGNALING

JAK2 BTK VAV1 STAT1

2.30e-0459724M39350
PathwayBIOCARTA_TPO_PATHWAY

JAK2 CSNK2A1 STAT1

2.39e-0424723M11520
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

JAK2 AGO2 AGO4 AGO3 CAMK2B TLN1 SPTB DLG4

2.53e-04327728M27565
PathwayBIOCARTA_TPO_PATHWAY

JAK2 CSNK2A1 STAT1

2.71e-0425723MM1519
PathwayREACTOME_MICRORNA_MIRNA_BIOGENESIS

AGO2 AGO4 AGO3

2.71e-0425723M712
PathwayREACTOME_CA2_PATHWAY

AGO2 AGO4 AGO3 PRKG1

2.79e-0462724M27321
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2

AGO2 AGO4 AGO3 CAMK2B

2.97e-0463724M27862
PathwayBIOCARTA_IFNG_PATHWAY

JAK2 STAT1

3.81e-046722MM1590
PathwayBIOCARTA_IFNG_PATHWAY

JAK2 STAT1

3.81e-046722M22085
PathwayREACTOME_TGFBR3_EXPRESSION

AGO2 AGO4 AGO3

3.82e-0428723M48253
PathwayWP_IL5_SIGNALING_PATHWAY

JAK2 BTK VAV1 STAT1

3.98e-0468724MM15930
PathwayREACTOME_PARACETAMOL_ADME

NAT1 CYP2E1 UGT1A9

4.24e-0429723M45015
PathwayWP_KIT_RECEPTOR_SIGNALING_PATHWAY

JAK2 BTK VAV1 STAT1

4.69e-0471724MM15947
PathwayREACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION

AGO2 AGO4 AGO3

5.70e-0432723M48012
PathwayKEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY

BTK VAV1 CHUK CHP1

5.78e-0475724M5436
PathwayWP_PROLACTIN_SIGNALING

JAK2 ZAP70 VAV1 STAT1

6.08e-0476724M39601
PathwayPID_EPO_PATHWAY

JAK2 BTK STAT1

6.24e-0433723M233
PathwayREACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX

AGO2 AGO4 AGO3

8.76e-0437723M29790
PathwayBIOCARTA_IL22BP_PATHWAY

JAK2 STAT1

9.05e-049722MM1419
PathwayBIOCARTA_IL22BP_PATHWAY

JAK2 STAT1

9.05e-049722M8066
PathwayWP_IL2_SIGNALING_PATHWAY

JAK2 VAV1 STAT1 CHUK

1.01e-0387724MM15915
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

SYT9 DLG4 SLITRK3 SYT10

1.01e-0387724M27617
PathwayREACTOME_PARACETAMOL_ADME

NAT1 CYP2E1 UGT1A9

1.02e-0339723MM15695
PathwayREACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS

AGO2 AGO4 AGO3 CAMK2B CSNK2A1 VAV1 CHUK

1.07e-03313727M27867
PathwayWP_PDGF_PATHWAY

VAV1 STAT1 CHUK

1.10e-0340723M39555
PathwayWP_IL5_SIGNALING

JAK2 BTK STAT1

1.10e-0340723M39392
PathwayPID_IFNG_PATHWAY

JAK2 CAMK2B STAT1

1.10e-0340723M161
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_RAS

JAK2 VAV1

1.13e-0310722MM15624
PathwayWP_IL6_SIGNALING

JAK2 VAV1 STAT1

1.36e-0343723M39656
PathwayREACTOME_SIGNALING_BY_SCF_KIT

JAK2 VAV1 STAT1

1.36e-0343723M508
PathwayREACTOME_INTERLEUKIN_6_SIGNALING

JAK2 STAT1

1.37e-0311722M1014
PathwayREACTOME_INTERLEUKIN_27_SIGNALING

JAK2 STAT1

1.37e-0311722M27897
PathwayWP_IL11_SIGNALING

JAK2 STAT1 CHUK

1.46e-0344723M39716
PathwayREACTOME_SIGNALING_BY_MODERATE_KINASE_ACTIVITY_BRAF_MUTANTS

JAK2 CAMK2B TLN1

1.55e-0345723M27623
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

FARP1 DOCK9 BTK DIAPH2 DLG4 SLITRK3 SKA1 ZAP70 VAV1 RHOT1

1.62e-036497210MM15690
PathwayREACTOME_INTERLEUKIN_35_SIGNALLING

JAK2 STAT1

1.64e-0312722M27860
PathwayWP_IL6_SIGNALING_PATHWAY

JAK2 BTK VAV1 STAT1

1.70e-03100724MM15826
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

AGO2 AGO4 AGO3

1.76e-0347723M29777
PathwayWP_THYMIC_STROMAL_LYMPHOPOIETIN_TSLP_SIGNALING

JAK2 BTK STAT1

1.76e-0347723M39380
PathwayPID_IL6_7_PATHWAY

JAK2 VAV1 STAT1

1.76e-0347723M183
PathwayPID_PI3KCI_PATHWAY

BTK PLEKHA2 ZAP70

1.87e-0348723M141
PathwayKEGG_MEDICUS_VARIANT_OLIGOMERIC_CONFORMATION_PRPC_TO_ANTEROGRADE_AXONAL_TRANSPORT

CSNK2A1 CSNK2A3

1.93e-0313722M47763
PathwayREACTOME_SIGNALING_BY_TGFBR3

AGO2 AGO4 AGO3

1.99e-0349723M48250
PathwayWP_TROP2_REGULATORY_SIGNALING

JAK2 TLN1 STAT1

1.99e-0349723M46458
PathwayKEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY

ZAP70 VAV1 CHUK CHP1

2.25e-03108724M9904
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_RAS

JAK2 VAV1

2.25e-0314722M27908
PathwayREACTOME_REGULATION_OF_IFNG_SIGNALING

JAK2 STAT1

2.25e-0314722M942
PathwayREACTOME_DRUG_ADME

NAT1 CYP2E1 UGT1A9 VAV1

2.32e-03109724M45012
PathwayPID_KIT_PATHWAY

JAK2 VAV1 STAT1

2.36e-0352723M231
PathwayKEGG_STARCH_AND_SUCROSE_METABOLISM

ENPP1 GBE1 UGT1A9

2.36e-0352723M14171
PathwayPID_CD8_TCR_PATHWAY

ZAP70 VAV1 CHUK

2.49e-0353723M88
PathwayPID_NFAT_3PATHWAY

CSNK2A1 CABIN1 CHP1

2.49e-0353723M113
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

JAK2 CAB39 AGO2 AGO4 AGO3 AXL CAMK2B CSNK2A1 TLN1 BTK PRKG1 CSNK2A3 LYST ZNF687 CHUK

1.21e-08910901536736316
Pubmed

Molecular dissection of human Argonaute proteins by DNA shuffling.

AGO2 AGO4 AGO3

6.69e-08490323748378
Pubmed

Argonaute proteins: potential biomarkers for human colon cancer.

AGO2 AGO4 AGO3

6.69e-08490320146808
Pubmed

Slicing-independent RISC activation requires the argonaute PAZ domain.

AGO2 AGO4 AGO3

6.69e-08490322795694
Pubmed

Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.

AGO2 AGO4 AGO3

6.69e-08490318771919
Pubmed

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.

AGO2 AGO4 AGO3

6.69e-08490315260970
Pubmed

ATP-dependent human RISC assembly pathways.

AGO2 AGO4 AGO3

6.69e-08490319966796
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CAB39 AGO2 PNPLA6 KRT16 SYT3 CAMK2B FARP1 CSNK2A1 TLN1 SPTB POR DLG4 ZNFX1 NDUFV1 WNK2 RHOT1 HNRNPU

1.37e-071431901737142655
Pubmed

Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.

AGO2 AGO4 AGO3

1.67e-07590319393748
Pubmed

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.

AGO2 AGO4 AGO3

1.67e-07590312414724
Pubmed

The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.

AGO2 AGO4 AGO3

1.67e-07590319324964
Pubmed

Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.

AGO2 AGO4 AGO3

1.67e-07590312526743
Pubmed

Differential expression of components of the microRNA machinery during mouse organogenesis.

AGO2 AGO4 AGO3

1.67e-07590316036130
Pubmed

Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development.

AGO2 AGO4 AGO3

5.82e-07790334907157
Pubmed

Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.

AGO2 AGO4 AGO3

5.82e-07790319536157
Pubmed

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.

AGO2 AGO4 AGO3

5.82e-07790319383768
Pubmed

Functional dissection of the human TNRC6 (GW182-related) family of proteins.

AGO2 AGO4 AGO3

5.82e-07790319470757
Pubmed

Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis.

AGO2 AGO4 AGO3

9.30e-07890319345100
Pubmed

Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis.

AGO2 AGO4 AGO3

9.30e-07890329021386
Pubmed

Identification of eight members of the Argonaute family in the human genome.

AGO2 AGO4 AGO3

1.39e-06990312906857
Pubmed

Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X.

SYT3 SYT9 SYT10

1.39e-06990310531343
Pubmed

Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.

SPDYE2 SPDYE2B SPDYE6

1.39e-06990336272447
Pubmed

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

JAK2 TLN1 ZAP70 VAV1 STAT1

3.83e-069090516273093
Pubmed

Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women.

NAT1 CYP2E1 MTRR

4.70e-061390320180013
Pubmed

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

SPDYE2 SPDYE2B SPDYE6

4.70e-061390315611625
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

CSNK2A1 DOCK9 SLC25A13 KIF19 DIAPH2 MYOM2 CSNK2A3 ME1 ZNF687

5.86e-0649790936774506
Pubmed

Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese.

JAK2 STAT1

6.62e-06290227965977
Pubmed

STAT1 activation in association with JAK2 exon 12 mutations.

JAK2 STAT1

6.62e-06290226635038
Pubmed

Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.

CSNK2A1 CSNK2A3

6.62e-06290214646071
Pubmed

The peptide encoded by a novel putative lncRNA HBVPTPAP inducing the apoptosis of hepatocellular carcinoma cells by modulating JAK/STAT signaling pathways.

JAK2 STAT1

6.62e-06290232755630
Pubmed

Lymphoblastic lymphoma in a colony of N:NIH(S)-bg-nu-xid mice.

BTK LYST

6.62e-0629021434498
Pubmed

Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.

CSNK2A1 CSNK2A3

6.62e-06290212860116
Pubmed

Neurotensin enhances nitric oxide generation via the JAK2-STAT1 pathway in murine macrophage Raw264.7 cells during costimulation with LPS and IFNgamma.

JAK2 STAT1

6.62e-06290216563502
Pubmed

The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav.

ZAP70 VAV1

6.62e-0629027798261
Pubmed

[The nucleotide sequence features of the mature microRNA seem to be responsible for the affinity to human Ago2 AND Ago3 proteins].

AGO2 AGO3

6.62e-06290221634124
Pubmed

Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis.

JAK2 STAT1

6.62e-06290212426001
Pubmed

Proximal FAD histidine residue influences interflavin electron transfer in cytochrome P450 reductase and methionine synthase reductase.

POR MTRR

6.62e-06290224589657
Pubmed

Assignment of casein kinase 2 alpha sequences to two different human chromosomes.

CSNK2A1 CSNK2A3

6.62e-0629021577469
Pubmed

Endothelial transcriptomic changes induced by oxidized low density lipoprotein disclose an up-regulation of Jak-Stat pathway.

JAK2 STAT1

6.62e-06290226028607
Pubmed

Non-Canonical Role of IKKα in the Regulation of STAT1 Phosphorylation in Antiviral Signaling.

STAT1 CHUK

6.62e-06290227992555
Pubmed

Bimolecular fluorescence complementation analysis of cytochrome p450 2c2, 2e1, and NADPH-cytochrome p450 reductase molecular interactions in living cells.

CYP2E1 POR

6.62e-06290215980100
Pubmed

Human Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNA.

AGO2 AGO3

6.62e-06290233122430
Pubmed

Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL.

JAK2 VAV1

6.62e-0629027530656
Pubmed

Molecular cloning of the human casein kinase II alpha subunit.

CSNK2A1 CSNK2A3

6.62e-0629022752008
Pubmed

Structure and sequence of an intronless gene for human casein kinase II-alpha subunit.

CSNK2A1 CSNK2A3

6.62e-0629028420794
Pubmed

Zap70 controls the interaction of talin with integrin to regulate the chemotactic directionality of T-cell migration.

TLN1 ZAP70

6.62e-06290220488542
Pubmed

Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.

JAK2 TLK1 BLZF1 CDCA7L STAT1 ZNF687

6.75e-0617690627229929
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

AGO2 AGO3 SYT3 CAMK2B FARP1 CSNK2A1 DIAPH2 DLG4 ZNFX1 CABIN1 WNK2 HNRNPU

7.16e-06963901228671696
Pubmed

Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs.

AGO2 AGO4 AGO3

9.16e-061690320102707
Pubmed

Characterization of a new family of cyclin-dependent kinase activators.

SPDYE2 SPDYE2B SPDYE6

1.11e-051790315574121
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

TLN1 SPTB PLS1

1.33e-051890312119179
Pubmed

Turning catalytically inactive human Argonaute proteins into active slicer enzymes.

AGO2 AGO3

1.98e-05390223665583
Pubmed

Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.

CSNK2A1 CSNK2A3

1.98e-05390215684395
Pubmed

JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model.

JAK2 STAT1

1.98e-05390231467427
Pubmed

Progesterone activates Janus Kinase 1/2 and activators of transcription 1 (JAK1-2/STAT1) pathway in human spermatozoa.

JAK2 STAT1

1.98e-05390222748021
Pubmed

Evolution of the Cdk-activator Speedy/RINGO in vertebrates.

SPDYE2 SPDYE6

1.98e-05390222763696
Pubmed

Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

JAK2 BTK

1.98e-0539027925280
Pubmed

Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.

CSNK2A1 CSNK2A3

1.98e-0539022174700
Pubmed

Foot-and-mouth disease virus structural protein VP3 degrades Janus kinase 1 to inhibit IFN-γ signal transduction pathways.

JAK2 STAT1

1.98e-05390226901336
Pubmed

Genetics of resistance to infection with Candida albicans in mice.

BTK LYST

1.98e-0539023058198
Pubmed

The roles of individual mammalian argonautes in RNA interference in vivo.

AGO2 AGO3

1.98e-05390224992693
Pubmed

Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit.

CSNK2A1 CSNK2A3

1.98e-0539021766873
Pubmed

Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study.

FARP1 UNC5C

1.98e-05390219475631
Pubmed

Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs.

JAK2 STAT1

1.98e-05390224820309
Pubmed

Role of x-linked immunodeficiency (xid) and NK activity in rejection of human tumor xenotransplants in nude mice.

BTK LYST

1.98e-0539028329195
Pubmed

Dampening of IFN-gamma-inducible gene expression in human choriocarcinoma cells is due to phosphatase-mediated inhibition of the JAK/STAT-1 pathway.

JAK2 STAT1

1.98e-05390217237409
Pubmed

POR overexpression induces tamoxifen-resistance in breast cancer through the STAT1/c-Myc pathway.

POR STAT1

1.98e-05390236321415
Pubmed

New immunodeficient mouse strains bred by introducing beige and xid mutations into the KSN nude strain.

BTK LYST

1.98e-0539028872993
Pubmed

Structure of C3PO and mechanism of human RISC activation.

AGO2 TSNAX

1.98e-05390221552258
Pubmed

Crystallization and preliminary characterization of crystals of human protein kinase CK2.

CSNK2A1 CSNK2A3

1.98e-05390211092945
Pubmed

Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells.

JAK2 BTK

1.98e-05390211413148
Pubmed

The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines.

JAK2 STAT1

1.98e-05390228112370
Pubmed

Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.

CSNK2A1 CSNK2A3

1.98e-05390212102635
Pubmed

Enhanced human tumor cell transplantability in a new congenic immunodeficient mouse; KSN-BNX.

BTK LYST

1.98e-0539029821307
Pubmed

The angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR.

JAK2 STAT1

1.98e-05390211152457
Pubmed

JAK2 and PD-L1 Amplification Enhance the Dynamic Expression of PD-L1 in Triple-negative Breast Cancer.

JAK2 STAT1

1.98e-05390229933930
Pubmed

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

JAK2 BTK

1.98e-0539028617237
Pubmed

Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade.

CAMK2B PRKG1

1.98e-05390221479273
Pubmed

Argonaute2 is the catalytic engine of mammalian RNAi.

AGO2 AGO3

1.98e-05390215284456
Pubmed

Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins.

AGO2 AGO4

1.98e-05390219946268
Pubmed

Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.

CSNK2A1 CSNK2A3

1.98e-05390220625391
Pubmed

Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1.

JAK2 STAT1

1.98e-05390222892029
Pubmed

Inhibition of Jak/STAT signaling ameliorates mice experimental nephrotic syndrome.

JAK2 STAT1

1.98e-05390217823504
Pubmed

Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.

LAYN TLN1

1.98e-05390218638481
Pubmed

Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation.

JAK2 STAT1

1.98e-05390220592027
Pubmed

Probucol inhibits JAK2-STAT pathway activation and protects human glomerular mesangial cells from tert-butyl hydroperoxide induced premature senescence.

JAK2 STAT1

1.98e-05390223984931
Pubmed

Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages.

BTK VAV1

1.98e-05390223825946
Pubmed

Axl modulates immune activation of smooth muscle cells in vein graft remodeling.

AXL STAT1

1.98e-05390226276821
Pubmed

The NIH-3 immunodeficient mouse is a model for Lyme borreliosis myositis and carditis.

BTK LYST

1.98e-0539021632468
Pubmed

Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study.

JAK2 STAT1

1.98e-05390225104439
Pubmed

Distinct effects of V617F and exon12-mutated JAK2 expressions on erythropoiesis in a human induced pluripotent stem cell (iPSC)-based model.

JAK2 STAT1

1.98e-05390233664283
Pubmed

Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons.

JAK2 STAT1

1.98e-05390219508864
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

TTLL12 CAB39 ZNF845 TLK1 CSNK2A1 TLN1 TUBGCP3 GBE1 TSNAX STAT1 ZNF687 HNRNPU

2.74e-051103901234189442
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

JAK2 TLK1 PNPLA6 MYO10 DOCK9 TLN1 DIAPH2 CABIN1 CHPF LYST WNK2 ZNF687

2.79e-051105901235748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

NAA35 ZMYND11 AGO2 PNPLA6 AGO3 CSNK2A1 SLC25A13 TUBGCP3 DLG4 VAV1 RHOT1 ZNF687

3.07e-051116901231753913
Pubmed

Murine chromosomal location of five bHLH-Zip transcription factor genes.

BTK SERPINC1 VAV1

3.26e-05249038530024
Pubmed

Dipyrithione inhibits IFN-gamma-induced JAK/STAT1 signaling pathway activation and IP-10/CXCL10 expression in RAW264.7 cells.

JAK2 STAT1

3.96e-05490220372968
Pubmed

Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis.

JAK2 STAT1

3.96e-05490219801665
Pubmed

Regulation of TFII-I activity by phosphorylation.

JAK2 BTK

3.96e-0549029837922
Pubmed

Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases.

JAK2 STAT1

3.96e-0549029452495
InteractionCD5 interactions

CSNK2A1 ZAP70 VAV1 HNRNPU

8.53e-0630884int:CD5
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

RTKN2 MYO10 FARP1 DOCK9 SPTB BTK PLEKHA2 VAV1

2.92e-07206588682
GeneFamilyArgonaute/PIWI family

AGO2 AGO4 AGO3

1.73e-068583408
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE2 SPDYE2B SPDYE6

6.75e-0612583756
GeneFamilySH2 domain containing

JAK2 BTK ZAP70 VAV1 STAT1

1.78e-05101585741
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

JAK2 MYO10 FARP1 TLN1

1.97e-05505841293
GeneFamilySynaptotagmins

SYT3 SYT9 SYT10

2.06e-0517583765
GeneFamilyEF-hand domain containing

FSTL5 SLC25A13 PLS1 RHOT1 CHP1

6.77e-04219585863
CoexpressionLIU_OVARIAN_CANCER_TUMORS_AND_XENOGRAFTS_KINASES_DN

JAK2 AXL BTK PRKG1

4.34e-0632904MM17
CoexpressionLIU_OVARIAN_CANCER_TUMORS_AND_XENOGRAFTS_KINASES_DN

JAK2 AXL BTK PRKG1

5.57e-0634904M45005
CoexpressionGSE46606_DAY1_VS_DAY3_CD40L_IL2_IL5_STIMULATED_IRF4HIGH_BCELL_DN

JAK2 CCNYL1 AXL PLEKHA2 ZNFX1 BLZF1 LYST

5.93e-06200907M9839
CoexpressionSASSON_RESPONSE_TO_GONADOTROPHINS_DN

TLK1 AXL TLN1 STAT1 CHUK

1.19e-0586905M17143
CoexpressionBROWNE_HCMV_INFECTION_14HR_DN

HOXB1 NDUFAF1 MYO10 AXL SPTB DIAPH2 HNRNPU

6.44e-05290907M13251
CoexpressionGSE46606_IRF4HIGH_VS_IRF4MID_CD40L_IL2_IL5_DAY3_STIMULATED_BCELL_DN

JAK2 CCNYL1 AXL POR LYST STAT1

6.51e-05199906M9846
CoexpressionGSE360_L_DONOVANI_VS_B_MALAYI_LOW_DOSE_DC_DN

ABCA6 EIF2B5 POR VAV1 NDUFV1 STAB1

6.69e-05200906M5204
CoexpressionGSE27786_LIN_NEG_VS_CD8_TCELL_DN

CAMK2B CSNK2A1 PLEKHA2 SERPINC1 LYST STAT1

6.69e-05200906M4777
CoexpressionGSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_6H_UP

PNPLA6 TUBGCP3 DIAPH2 TSNAX RHOT1 STAB1

6.69e-05200906M9922
CoexpressionMANALO_HYPOXIA_UP

P4HA2 AXL ENPP1 FER1L4 DIAPH2 GBE1

7.67e-05205906M259
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P4HA2 AXL ENPP1 CHPF ME1 PLS1

1.84e-06181906cd46eba2e03fd15d8de8e875793ae2f51fa98b3b
ToppCelldroplet-Marrow-BM-30m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P4HA2 AXL ENPP1 CHPF ME1 PLS1

1.84e-06181906c7d12c7de227c9433ec2303b8929e957b833f59b
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RTKN2 ZNF845 LAYN SLC25A13 ZNF816 STAB1

2.15e-0618690674eb69a52090f9e2426a47e03a1c478ee0cfec18
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

JAK2 AXL UNC5C MYOM2 PRKG1 WNK2

2.58e-06192906bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

JAK2 AXL UNC5C MYOM2 PRKG1 WNK2

2.58e-06192906b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCellNeuronal-Excitatory-eH(THEMIS)|Neuronal / cells hierarchy compared to all cells using T-Statistic

LAYN MYO10 UNC5C GBE1 MYOM2 SYT10

3.27e-06200906651ee624ab62720546cf71c2191996b5be3ce846
ToppCellLPS_IL1RA|World / Treatment groups by lineage, cell group, cell type

JAK2 DOCK9 TLN1 DIAPH2 GBE1 ZNFX1

3.27e-06200906a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

CEP78 CYP2E1 ENPP1 MYOM2 ZAP70

1.63e-05156905afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCellEntopeduncular-Macroglia-OLIGODENDROCYTE-O1-Trf|Entopeduncular / BrainAtlas - Mouse McCarroll V32

RTKN2 ABCA6 PLS1 VAV1

1.72e-0576904efbbbf91bca35720d8ecddb076f2c9f4de25e44d
ToppCellEntopeduncular-Macroglia-OLIGODENDROCYTE-O1|Entopeduncular / BrainAtlas - Mouse McCarroll V32

RTKN2 ABCA6 PLS1 VAV1

1.72e-0576904254d18bece2676faa4bbeb8d48b1d327ab3c2215
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP2E1 SLC25A13 POR GBE1 ME1

1.84e-05160905c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TTLL12 LAYN DOCK9 NAP1L2 PAN2

1.90e-051619055fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

TTLL12 JAK2 ABCA6 DIAPH2 WNK2

2.39e-0516990584b898a9fd8ced67c6a501d5cef6416f519902c4
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

ENPP1 UNC5C MYOM2 PRKG1 CHRNB3

2.68e-05173905a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ZNF845 AGO2 CCNYL1 MYO10 HNRNPU

2.99e-05177905eb0cfe8e9a91910f9979608ed47add48d98ce4dd
ToppCell10x5'v1-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

NAT1 CYP2E1 ABCA6 ENPP1 DOCK9

3.15e-05179905bc95c3e7edc5fc6fc913b09f087d221df64c6f48
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PNPLA6 CEP78 KIF19 MYOM2 ZAP70

3.24e-05180905557453b74d4a9cc95ed1c7b9a9a58e45eb02ed6a
ToppCelldroplet-Lung-nan-18m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TLK1 SYT3 AXL ME1 CTTNBP2NL

3.24e-0518090543fd5c498a87bb078d101298b472656f3294686a
ToppCellAdult-Mesenchymal-pericyte_cell-D122|Adult / Lineage, Cell type, age group and donor

MYO10 AXL SPTB UNC5C PRKG1

3.50e-05183905fc31a43a637423cb3bb9aa184a3a889a0b9aaea6
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P4HA2 ENPP1 CHPF ME1 PLS1

3.59e-051849051e54fd372c6e6a298f427b807c14cc49aaaffe80
ToppCellCOVID-19-Heart-CM_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

CAMK2B SPTB MYOM2 RPL3L WNK2

3.59e-05184905e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CEP78 MYO10 AXL MYOM2 ZAP70

3.78e-05186905facc1bd8920003ad03d1893c32fc606d82b4d50a
ToppCellTuft|World / Class top

PNPLA6 CAMK2B SPTB VAV1 WNK2

3.78e-05186905f4d83f15ab7b49c0920a322cd832413ece7c9948
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_3|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ZNF845 LAYN SLC25A13 ZNF816 STAB1

3.88e-051879051eed2c1a05e80a7c8f639437c117afe0c18dfb0c
ToppCellTuft-tuft-2|World / Class top

PNPLA6 CAMK2B SPTB VAV1 WNK2

3.88e-051879054ec6eee866619dfe13c84f5d2e812bb380d37139
ToppCellMS-Treg-CD4_Treg|MS / Condition, Cell_class and T cell subcluster

RTKN2 TLK1 LAYN CEP78 CHRNB3

4.08e-05189905b1310eed6113b3536868340a5b2b2587ad377fa9
ToppCellMS-Treg|MS / Condition, Cell_class and T cell subcluster

RTKN2 TLK1 LAYN CEP78 CHRNB3

4.08e-051899053fa79242fb3dba4a3f52276da0124ba260423fb6
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

CAMK2B MYOM2 PRKG1 RPL3L WNK2

4.19e-05190905fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CEP78 MYO10 AXL MYOM2 ZAP70

4.19e-05190905600b9674197f743dea1d19d3df0fc993b6e6aa25
ToppCellCOVID-19-kidney-vSMC/Pericyte|kidney / Disease (COVID-19 only), tissue and cell type

KRT16 AXL UNC5C MYOM2 PRKG1

4.29e-05191905fad8eaa536001b911d05ae2b12150c2398cc6f88
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CEP78 MYO10 AXL MYOM2 ZAP70

4.40e-05192905c5f77c2103841505d13e09173549811312ef2f01
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CEP78 MYO10 AXL MYOM2 ZAP70

4.40e-05192905e981162f387a31111c0ae8355dbe9db5785c4838
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

JAK2 LAYN CYP2E1 AXL CTTNBP2NL

4.62e-05194905b16ed97eb6b7b7a220e943474c0d85c141b6e3a5
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

JAK2 LAYN CYP2E1 AXL CTTNBP2NL

4.62e-051949052210f0755882d8f04edb4c109fb17c3f9149f6f7
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ABCA6 MYO10 FARP1 UNC5C PRKG1

4.62e-05194905b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

P4HA2 ABCA6 AXL FXYD5 ME1

4.62e-05194905b829a63b51b92507a53ffd0393bd9458b2b9440f
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RTKN2 LAYN FXYD5 ZAP70 STAT1

4.74e-051959056ddce0cce14f737e45b8f57802c6a8ad07686262
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

RTKN2 LAYN FXYD5 ZAP70 STAT1

4.74e-05195905e6212373cc3c6c98f76e104e2ac1afa68965cc5f
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ABCA6 MYO10 FARP1 UNC5C PRKG1

4.74e-051959050e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellMild_COVID-19-T/NK-CD4+_T_2|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

RTKN2 LAYN FXYD5 ZAP70 STAT1

4.85e-05196905e50d03d8428dc4526e4607b6b4e99f0812a0ad31
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

JAK2 AXL UNC5C PRKG1 WNK2

4.85e-051969051522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

JAK2 AXL UNC5C PRKG1 WNK2

4.85e-051969051c8294014713684b50885e638668f2ce75f357f0
ToppCellParenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF845 CCNYL1 ENPP1 MYOM2 ZNF687

5.09e-05198905cc2b5b632e73e44bb60050f0db10d8f0dbb859fa
ToppCellNeuronal-Excitatory-eH(THEMIS)-DCSTAMP-|Neuronal / cells hierarchy compared to all cells using T-Statistic

HOXB1 GBE1 MYOM2 SYT10 CHRNB3

5.34e-052009051755f7ffe59581f429160aec32669e74d69f5345
ToppCellNeuronal-Excitatory-eH(THEMIS)-DCSTAMP---L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

HOXB1 GBE1 MYOM2 SYT10 CHRNB3

5.34e-0520090574fb44a7f6d7439c57695dad4b7a6626e3ad422e
ToppCellNeuronal-Excitatory-eH(THEMIS)-DCSTAMP--|Neuronal / cells hierarchy compared to all cells using T-Statistic

HOXB1 GBE1 MYOM2 SYT10 CHRNB3

5.34e-0520090511dc0e6d3242e2cf2d9353e97c9a6f09791648cb
ToppCellNeuronal-Excitatory-eH(THEMIS)-DCSTAMP|Neuronal / cells hierarchy compared to all cells using T-Statistic

HOXB1 GBE1 MYOM2 SYT10 CHRNB3

5.34e-05200905e20f1b1a429eeaa6b66a71f96680699724e40111
ToppCelldroplet-Heart-HEART-1m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AGO3 SLC25A13 VAV1 ZNF687

1.28e-04127904983489a69d3b1f1fe21110a862ac1dba53e9d31c
ToppCellCOVID-19_Moderate-multiplets|COVID-19_Moderate / disease group, cell group and cell class

CEP78 CYP2E1 ENPP1 ZAP70

2.25e-04147904baf15c773d7751bc6f64d4974a22738626f2b3ff
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

KIF19 MYOM2 ME1 ZAP70

2.31e-04148904e7bbb5ddf44b11b8495e83863fbf1fd9f3f24472
ToppCell368C-Lymphocytic-NK_cells|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

P4HA2 CEP78 ENPP1 MYOM2

2.43e-0415090417b3ac5ddc47b9cba0a27b268d63a6e491b2b111
ToppCellCOVID-19_Severe-multiplets|COVID-19_Severe / disease group, cell group and cell class

CEP78 CYP2E1 ENPP1 ZAP70

2.55e-04152904451745151322c2fcea22dbb3dba681e12634a510
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NDUFAF1 MYOM2 PRKG1 CHRNB3

2.62e-041539041524557514668f515ac1bbe847611f564b265b42
ToppCellileum-BEST4+_Enterocytes|ileum / shred on tissue and cell subclass

CCNYL1 UNC5C PRKG1 SYT10

2.68e-04154904608e9c982125e0c2c15b86b1920813845a0db81f
ToppCell10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3|bone_marrow / Manually curated celltypes from each tissue

CYP2E1 ENPP1 UNC5C PRKG1

2.75e-0415590483430a64c2cb5ad29caa3dacba76c28dd204ac40
ToppCellE12.5-Hematopoietic|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

BTK FXYD5 VAV1 STAB1

2.89e-04157904344351c7534440532c6cd4a95782ac90b10d45f3
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-FB-1|E18.5-samps / Age Group, Lineage, Cell class and subclass

HOXB1 SYT3 UNC5C ZNF687

3.03e-04159904b4bc888e978b1b577721b891b0af6ba9a1607044
ToppCelldroplet-Kidney-nan-3m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AXL FXYD5 CTTNBP2NL STAB1

3.03e-04159904bea6e96ba40ebfc1e38687bfa1c61fe227c5a84d
ToppCellE12.5-Hematopoietic-Immune-immune_cell_unspecified|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

BTK FXYD5 VAV1 STAB1

3.10e-041609045a4a5a50dfdf6af9406e4f685712f7fe390a02f3
ToppCellE12.5-Hematopoietic-Immune|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

BTK FXYD5 VAV1 STAB1

3.10e-04160904cd59830a524c14a1f591c5c615b55510e4104e5b
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RTKN2 KRT16 ME1 RPL3L

3.18e-041619041e17a993126e1f2a25ee7dfbb95a74ccb2a26791
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BTK FXYD5 SERPINC1 VAV1

3.25e-041629049d6931619f5eb847c79d00ff5ae031fef30fd55c
ToppCellfacs-Kidney-nan-3m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF19 MTRR ZAP70 VAV1

3.33e-04163904385b24e18df5ef92108483de312d6c85a1e6d145
ToppCelldroplet-Pancreas-Endocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AXL BTK FXYD5 VAV1

3.33e-04163904644c8a8af6a378fced4c70dec9a0de906f8d6e69
ToppCellfacs-Kidney-nan-3m-Lymphocytic-T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF19 MTRR ZAP70 VAV1

3.33e-041639048004cc0b3428be08b89957b563cd8799f822d931
ToppCelldroplet-Pancreas-Endocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AXL BTK FXYD5 VAV1

3.33e-04163904aaff80d254131d1f1230bb12b6f43bc061ab5ab3
ToppCelldroplet-Pancreas-Endocrine-18m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AXL BTK FXYD5 VAV1

3.33e-041639048b0f8a2d5b38f3bbff265211a7607acc85fa38b0
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NAA35 CCNYL1 ZNF816 STAB1

3.49e-0416590476abebe80e5f8bf44825bb619ae86fcb6f66ffeb
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MYO10 CAMK2B ZNF816 DLG4

3.57e-04166904f62db9d9b6c9dd8f2afcaea0fc5f8c69f50205b2
ToppCelldroplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CAMK2B KIF19 ZAP70 CDCA7L

3.65e-04167904895844a45721988788d01120eb880603ba3ca139
ToppCelldroplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CAMK2B KIF19 ZAP70 CDCA7L

3.65e-04167904cde82e3dacf347226a78873b166608b7851b34d4
ToppCelldroplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CAMK2B KIF19 ZAP70 CDCA7L

3.65e-041679046f54a699d9266c5f09ed890a11b403a6c8476fc1
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

AXL ENPP1 CAMK2B SPTB

3.65e-04167904c4e321bb87512ea839f324c92c0f1afea891483f
ToppCellfacs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP2E1 UGT1A9 SKA1 ME1

3.82e-04169904ee27bcfe3f9a295ec5fb0a375d77d1050e5cbaad
ToppCellfacs-Pancreas-Endocrine-18m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AXL BTK FXYD5 VAV1

3.82e-041699040e3d0b71fc21fd1de7034d13895608de5494fad8
ToppCellfacs-Marrow-KLS-3m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P4HA2 ENPP1 CHPF PLS1

3.82e-04169904b798b91567d2f49082e2d8a337169f241c8d2080
ToppCellfacs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP2E1 UGT1A9 SKA1 ME1

3.82e-04169904922086f218135b734b7d370b871923e50141edce
ToppCellfacs-Pancreas-Endocrine-18m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AXL BTK FXYD5 VAV1

3.82e-04169904c68a305069a149d66dfdeef2a8010f460dc1da3b
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

ABCA6 AXL UNC5C DIAPH2

3.82e-041699046373562ab3b1765060212a6a53d6543e7e942e80
ToppCellfacs-Pancreas-Endocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AXL BTK FXYD5 VAV1

3.82e-0416990480089dfb1f0f4d6bdf6ca161e902b38011992dfd
ToppCellfacs-Large_Intestine-Proximal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNPLA6 CAMK2B VAV1 WNK2

3.90e-04170904c638dfde9ce30190abbe0caea1c3eb874af09857
ToppCellE16.5-Immune-Immune_Myeloid|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BTK FXYD5 VAV1 STAB1

3.90e-04170904a249696c6aae08e83f44b263fc838582a2736ee5
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CYP2E1 ENPP1 FXYD5 PRKG1

3.90e-041709046c65ddb496030bb479ef346cc37a9d4dfa6b824f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L6_THEMIS_C6orf48|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GBE1 MYOM2 SYT10 CHRNB3

3.99e-0417190475279ca22f5dd6cfee11c83f3a7b5f828cdec1c6
ToppCellE16.5-Immune|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BTK FXYD5 VAV1 STAB1

3.99e-04171904b5916748fa0cecc887527be645df88a9ebd0a822
ToppCelldroplet-Kidney-KIDNEY-1m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AXL CAMK2B CTTNBP2NL VAV1

3.99e-04171904d9ad6a3bce3556abd24af1630bf4a99594437c3a
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

SPTB UNC5C MYOM2 PRKG1

4.08e-04172904c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCell10x5'v1-week_12-13-Myeloid_macrophage-stroma-monocytoid_macrophage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ABCA6 AXL CCDC110 STAB1

4.08e-041729049befd44bce43eb5dc1fe3d2e44608f442cf74a47
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AXL BTK FXYD5 VAV1

4.17e-04173904279efbab7810fa60ab12ea5d09a84800df4adef0
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTKN2 AXL CTTNBP2NL STAB1

4.17e-0417390426bba58f9fb215d1d155504906cd77e8774f6936
ToppCelldroplet-Lung-LUNG-1m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTKN2 AXL CTTNBP2NL STAB1

4.17e-0417390469b404e92aad3e6dff67e75466f073f20a71f13f
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAMK2B SPTB VAV1 WNK2

4.17e-04173904f0eb48c1283bdde313bb75f6ffc0d2626922d24b
ToppCellfacs-Marrow-KLS-18m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P4HA2 ENPP1 CHPF PLS1

4.17e-04173904295bfe1efa648173c2d5981025bc61c576baf53f
ToppCellImmune_cells-pro-B|World / Lineage and Cell class

CAMK2B KIF19 PLEKHA2 RPL3L

4.26e-04174904e173adbf5789dfa20f3cbc668efde5f0992ac219
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RTKN2 KRT16 SYT3 SKA1

4.26e-04174904dbb4e1a6c3319ce40f81bfd2d1745a88a2cc412e
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P4HA2 ENPP1 CHPF PLS1

4.26e-04174904cdfc50e5383c8670ce5109736aff36406f46c03d
ToppCellTCGA-Colorectal-Recurrent_Tumor|TCGA-Colorectal / Sample_Type by Project: Shred V9

CYP2E1 UGT1A9 SERPINC1 ETNPPL

4.35e-041759047f74961436f88c0e380819095e6104489914d765
ToppCellTCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

CYP2E1 UGT1A9 SERPINC1 ETNPPL

4.35e-04175904bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCell3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CYP2E1 ENPP1 FXYD5 PLEKHA2

4.35e-04175904f2c3e0f728a43d6988e793c8a50c964f7447db82
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AXL BTK FXYD5 VAV1

4.45e-041769046548797336c9f4ca0f38e74a2c629e2a4defa252
Diseaseliver cancer (is_implicated_in)

JAK2 CHUK

8.54e-055872DOID:3571 (is_implicated_in)
Diseasethrombosis (implicated_via_orthology)

JAK2 SERPINC1

3.81e-0410872DOID:0060903 (implicated_via_orthology)
Diseasehistidine betaine (hercynine) measurement

P4HA2 UGT1A9

4.65e-0411872EFO_0800972
DiseaseBipolar Disorder

DOCK9 FSTL5 DLG4 TSNAX NDUFV1 CHRNB3 STAB1

5.30e-04477877C0005586
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

JAK2 CYP2E1 MTRR

7.87e-0461873C1961102
Diseasethrombosis (is_implicated_in)

JAK2 SERPINC1

8.80e-0415872DOID:0060903 (is_implicated_in)
Diseaseulcerative colitis (is_implicated_in)

JAK2 MTRR

1.14e-0317872DOID:8577 (is_implicated_in)
Diseasefamilial hyperlipidemia (biomarker_via_orthology)

CYP2E1 SERPINC1

1.42e-0319872DOID:1168 (biomarker_via_orthology)
DiseaseDeep Vein Thrombosis

JAK2 SERPINC1

1.74e-0321872C0149871
DiseaseVenous Thrombosis

JAK2 SERPINC1

1.74e-0321872C0042487
DiseaseDrug toxicity

NAT1 CYP2E1 MTRR

1.99e-0384873C0013221
DiseaseAdverse reaction to drug

NAT1 CYP2E1 MTRR

1.99e-0384873C0041755
DiseaseNeoplasm Invasiveness

CYP2E1 AXL TLN1 RPL3L

2.18e-03184874C0027626
Diseaseodontogenesis

HOXB1 NALF2

2.27e-0324872GO_0042476
Diseasecolon adenocarcinoma (is_implicated_in)

JAK2 STAT1

2.67e-0326872DOID:234 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
HRRFNYKDNTDLIEF

NAT1

241

P18440
ALKAQHRDTFIEERY

CTTNBP2NL

31

Q9P2B4
FLEKAADSIRYISRH

CHRNB3

391

Q05901
YLESKQFLHRDLAAR

BTK

511

Q06187
KTFLEVRDQEHYREF

ABCA6

1171

Q8N139
KLLSAEFLEQHYDRF

CAB39

196

Q9Y376
KLRRDSAADFFSHYE

CEP78

6

Q5JTW2
AFRARYHLVDKEHDS

AGO3

811

Q9H9G7
VAFRARYHLVDKDHD

AGO4

811

Q9HCK5
RDDLYVSDAFHKAFL

SERPINC1

391

P01008
DFKYRQRLDIDLTHL

DIAPH2

466

O60879
EDDPFFYDEHTLRKR

FXYD5

131

Q96DB9
YHIKNRDANRSLDIF

CCNYL1

151

Q8N7R7
SRFLHDNIVEYAKRL

ETNPPL

81

Q8TBG4
FRARYHLVDKEHDSA

AGO2

811

Q9UKV8
RAANLESKFLREFHD

NAP1L2

121

Q9ULW6
ADILFRKHFDYNDEK

CYP2E1

181

P05181
ALDSQRKLQFYEDRH

JAK2

756

O60674
RDLRTFKVEHEFDAF

PAN2

221

Q504Q3
ELYEKVFSRRADRHS

PNPLA6

951

Q8IY17
NFEHLNSDFDRYLLL

ME1

61

P48163
AEEFANRLSKDAHRY

POR

91

P16435
DDLQYHFERLAREKN

BLZF1

171

Q9H2G9
EFFHKSIQLDLERYS

CHUK

481

O15111
AHSDFIVRLYRTFKD

PRKG1

416

Q13976
KVIYFHDTSRRLNFE

LAYN

51

Q6UX15
IDKRLQELGARHFYD

MTRR

111

Q9UBK8
EYFLFEFHDTRLRLQ

FER1L4

71

A9Z1Z3
VFRNYIKRAADHLEA

EIF2B5

631

Q13144
FSQDIKDSRAYFHLL

PLS1

291

Q14651
YLFLQSTFDKHDLDR

RHOT1

306

Q8IXI2
DTYNCDLHFKISRDR

HNRNPU

291

Q00839
LRESRFDFIYDLFEH

MYO10

576

Q9HD67
RLAADDFRTKYEHEL

KRT16

196

P08779
DFRTKYEHELALRQT

KRT16

201

P08779
LSFRLDFNEHYKARE

TUBGCP3

876

Q96CW5
FHDTLLRKYAEERNG

ENPP1

776

P22413
QRLDRHAQEKYDEFD

NALF2

251

O75949
QDVRFHSKYFTEELR

CDCA7L

56

Q96GN5
DFNADKHLALEEFYR

FSTL5

226

Q8N475
FDFSRNDERDTFKHL

P4HA2

431

O15460
RAHRSREKSYLFDVA

KIF19

56

Q2TAC6
EALDFLDKLLRYDHQ

CSNK2A3

296

Q8NEV1
QFHLTDDDLLRYKFL

GBE1

566

Q04446
EFHFNKYLSRARRVE

HOXB1

221

P14653
RFEESAKAYHELLEA

CABIN1

51

Q9Y6J0
EKRRDFERLAHLYDT

DOCK9

1746

Q9BZ29
FDEALDREHLAKNKY

FARP1

171

Q9Y4F1
SFDKAIRDEAIYHFR

NDUFAF1

81

Q9Y375
EALDFLDKLLRYDHQ

CSNK2A1

296

P68400
EYSRFEAKIHDLREQ

DLG4

396

P78352
QEDFVFSKYRHRALL

LYST

386

Q99698
SDHFSNKERSRRYAI

RTKN2

116

Q8IZC4
IEEHENSGKFLRRYF

PLEKHA2

16

Q9HB19
ELAQRKLHFSVYDFD

SYT3

376

Q9BQG1
NDLEARKLHFSVYDF

SYT9

296

Q86SS6
RKLHFSVYDFDRFSR

SYT9

301

Q86SS6
DFHRFYFENLLAKNS

CAMK2B

581

Q13554
RFHDLLSQLDDQYSR

STAT1

56

P42224
RNLYHRFIDEETKDT

SKA1

191

Q96BD8
FAEHLSDECRRRFYK

RPL3L

106

Q92901
KDEDRIFTNLYGRHD

NDUFV1

36

P49821
YLHENKLDVFRNDTF

SLITRK3

131

O94933
DDEDSKQNIFHFLYR

SPDYE2B

261

A6NHP3
ISRREKFHFDNYTHE

CCDC110

791

Q8TBZ0
ERKRHLTYAEFTQFL

SLC25A13

141

Q9UJS0
LHKAFARAELERTYQ

CHPF

336

Q8IZ52
RSNKLHFAFRLYDLD

CHP1

111

Q99653
DEAFSFKSNLERHRI

ZNF845

501

Q96IR2
AYRKEDRFDVHQLAN

TLK1

716

Q9UKI8
YLEEKNFVHRDLAAR

ZAP70

451

P43403
KFELDSEQVRYEHRF

NAA35

606

Q5VZE5
EEHETLLLRRKFFYS

TLN1

186

Q9Y490
DDEDSKQNIFHFLYR

SPDYE2

261

Q495Y8
DDEDSKQNIFHFLYR

SPDYE6

261

P0CI01
RRGDSYDLKDFVNLH

VAV1

436

P15498
EYLSTKRFIHRDLAA

AXL

661

P30530
RDKHASFFSLRLLEY

STAB1

1591

Q9NY15
LSKDRNFHVFLEYDQ

SNX5

156

Q9Y5X3
DFDHVTLLRDKFRDF

SPTB

1721

P11277
YTLEDLDREFKAFAH

UGT1A9

81

O60656
NRKLHFSVYDFDRFS

SYT10

311

Q6XYQ8
DADILFNFSHFKDYR

TTLL12

331

Q14166
AIYLDTHFRLLREDF

ZNFX1

366

Q9P2E3
SFQQELDARHDKYER

TSNAX

41

Q99598
VYHSKCLSDEFRLRD

ZMYND11

121

Q15326
AFSLEKSLARHYDRR

ZNF687

541

Q8N1G0
RYEIKDLLSHAFFAE

WNK2

441

Q9Y3S1
VYRKNHRDFESDIID

UNC5C

401

O95185
DKVFRSDSYLAEHQR

ZNF816

431

Q0VGE8
DKRFSAHYDAVEAEL

FAM50B

46

Q9Y247
YGEAKRQRFLSELAH

MYOM2

96

P54296