Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent activity

ABCA2 ATP13A1 ABCC9 XRCC3 ATP8B2 DNAH14 ABCC8 AACS DDX60L DNAH8 ATP2B3 DYNC1H1 ALPL KIF2C

2.35e-0561412214GO:0140657
GeneOntologyMolecularFunctionsulfonylurea receptor activity

ABCC9 ABCC8

3.70e-0521222GO:0008281
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCA2 ATP13A1 ABCC9 ATP8B2 ABCC8 DDX60L DNAH8 ATP2B3 DYNC1H1 ALPL KIF2C

8.38e-0544112211GO:0016887
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH14 DNAH8 DYNC1H1

1.70e-04181223GO:0008569
GeneOntologyMolecularFunctionABC-type transporter activity

ABCA2 ATP13A1 ABCC9 ABCC8

2.27e-04491224GO:0140359
GeneOntologyMolecularFunctionNAD transmembrane transporter activity

SLC25A51 SLC25A52

3.66e-0451222GO:0051724
GeneOntologyMolecularFunctionATP-activated inward rectifier potassium channel activity

ABCC9 ABCC8

5.47e-0461222GO:0015272
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCA2 ATP13A1 ABCC9 ABCC8 ATP2B3

5.52e-041091225GO:0042626
GeneOntologyMolecularFunctionATPase-coupled monoatomic cation transmembrane transporter activity

ATP13A1 ABCC9 ABCC8 ATP2B3

5.63e-04621224GO:0019829
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH14 DNAH8 DYNC1H1

6.52e-04281223GO:0051959
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ABCA2 ATP13A1 SLC26A2 SLC6A17 ABCC9 SLC39A10 SLC4A1 SLC12A4 ABCC8 ATP2B3

6.99e-0447712210GO:0022804
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH14 DNAH8 DYNC1H1 KIF2C

8.91e-04701224GO:0003777
GeneOntologyMolecularFunctionbicarbonate transmembrane transporter activity

SLC26A2 SLC39A10 SLC4A1

9.70e-04321223GO:0015106
GeneOntologyCellularComponentpotassium ion-transporting ATPase complex

ABCC9 ABCC8

1.08e-0431262GO:0031004
GeneOntologyCellularComponentinward rectifying potassium channel

ABCC9 ABCC8

2.15e-0441262GO:0008282
GeneOntologyCellularComponentdynein complex

DNAH14 DYNC2LI1 DNAH8 DYNC1H1

3.15e-04541264GO:0030286
DomainARM-type_fold

USP34 MYBBP1A IPO7 CWC22 SIL1 RIF1 JUP PSME4 ZER1 CFAP69 AGBL1 TARBP1

2.10e-0633912112IPR016024
DomainLRR_TYP

LRRC39 ERBIN CNOT6 LRRC19 LRFN5 LRRC1 PODN LRRC7 ADGRA3

2.29e-061771219SM00369
DomainLeu-rich_rpt_typical-subtyp

LRRC39 ERBIN CNOT6 LRRC19 LRFN5 LRRC1 PODN LRRC7 ADGRA3

2.29e-061771219IPR003591
Domain-

LRRC39 NLRX1 ERBIN CNOT6 LRRC19 LRFN5 LRRC1 PODN ZER1 LRRC7 ADGRA3

7.75e-06321121113.80.10.10
DomainL_dom-like

LRRC39 NLRX1 ERBIN CNOT6 LRRC19 LRFN5 LRRC1 PODN ZER1 LRRC7 ADGRA3

9.49e-0632812111IPR032675
DomainLeu-rich_rpt

LRRC39 NLRX1 ERBIN CNOT6 LRRC19 LRFN5 LRRC1 PODN LRRC7 ADGRA3

1.08e-0527112110IPR001611
DomainLRR_1

LRRC39 ERBIN CNOT6 LRRC19 LRFN5 LRRC1 PODN LRRC7 ADGRA3

1.29e-052191219PF00560
DomainLRR_8

LRRC39 ERBIN CNOT6 LRRC19 LRRC1 PODN LRRC7 ADGRA3

1.57e-051711218PF13855
DomainSulphorea_rcpt

ABCC9 ABCC8

4.16e-0521212IPR000388
DomainGrip

RGPD8 GCC2 RGPD5

4.21e-05111213SM00755
DomainGRIP

RGPD8 GCC2 RGPD5

4.21e-05111213PF01465
DomainLRR

LRRC39 ERBIN CNOT6 LRFN5 LRRC1 PODN LRRC7 ADGRA3

4.98e-052011218PS51450
DomainGRIP_dom

RGPD8 GCC2 RGPD5

5.59e-05121213IPR000237
DomainGRIP

RGPD8 GCC2 RGPD5

5.59e-05121213PS50913
DomainARM-like

IPO7 SIL1 RIF1 JUP PSME4 ZER1 CFAP69 AGBL1 TARBP1

6.65e-052701219IPR011989
DomainDynein_heavy_chain_D4_dom

DNAH14 DNAH8 DYNC1H1

9.16e-05141213IPR024317
DomainDynein_HC_stalk

DNAH14 DNAH8 DYNC1H1

9.16e-05141213IPR024743
DomainMT

DNAH14 DNAH8 DYNC1H1

9.16e-05141213PF12777
DomainAAA_8

DNAH14 DNAH8 DYNC1H1

9.16e-05141213PF12780
DomainDHC_fam

DNAH14 DNAH8 DYNC1H1

1.14e-04151213IPR026983
DomainDynein_heavy

DNAH14 DNAH8 DYNC1H1

1.14e-04151213PF03028
DomainDynein_heavy_dom

DNAH14 DNAH8 DYNC1H1

1.14e-04151213IPR004273
DomainTAFH

CBFA2T3 TAF4B

4.11e-0451212SM00549
DomainTAFH_NHR1

CBFA2T3 TAF4B

4.11e-0451212IPR003894
DomainTAFH

CBFA2T3 TAF4B

4.11e-0451212PS51119
DomainTAFH

CBFA2T3 TAF4B

4.11e-0451212PF07531
Domain-

IPO7 SIL1 RIF1 JUP PSME4 ZER1 CFAP69

6.12e-0422212171.25.10.10
DomainFAST_2

FASTK FASTKD3

6.14e-0461212PF08368
DomainRAP

FASTK FASTKD3

6.14e-0461212SM00952
DomainRAP

FASTK FASTKD3

6.14e-0461212PF08373
DomainRAP

FASTK FASTKD3

6.14e-0461212PS51286
DomainFAST_1

FASTK FASTKD3

6.14e-0461212PF06743
DomainFAST_Leu-rich

FASTK FASTKD3

6.14e-0461212IPR010622
DomainFAST_2

FASTK FASTKD3

6.14e-0461212IPR013579
DomainRAP

FASTK FASTKD3

6.14e-0461212IPR013584
DomainRab_bind

RGPD8 GCC2

8.56e-0471212PF16704
DomainCXCR4/ACKR2

ACKR2 CX3CR1

8.56e-0471212IPR001277
DomainGCC2_Rab_bind

RGPD8 GCC2

8.56e-0471212IPR032023
DomainDHC_N1

DNAH8 DYNC1H1

1.14e-0381212PF08385
DomainDynein_heavy_dom-1

DNAH8 DYNC1H1

1.14e-0381212IPR013594
DomainATPase_P-typ_cyto_domN

ATP13A1 ATP8B2 ATP2B3

1.49e-03351213IPR023299
DomainATPase_P-typ_P_site

ATP13A1 ATP8B2 ATP2B3

1.62e-03361213IPR018303
DomainP_typ_ATPase

ATP13A1 ATP8B2 ATP2B3

1.62e-03361213IPR001757
DomainATPASE_E1_E2

ATP13A1 ATP8B2 ATP2B3

1.62e-03361213PS00154
DomainATPase_P-typ_transduc_dom_A

ATP13A1 ATP8B2 ATP2B3

1.75e-03371213IPR008250
DomainE1-E2_ATPase

ATP13A1 ATP8B2 ATP2B3

1.75e-03371213PF00122
DomainLRR_5

LRFN5 PODN

1.81e-03101212PF13306
DomainLRR_5

LRFN5 PODN

1.81e-03101212IPR026906
Domain-

RGPD8 GCC2

1.81e-031012121.10.220.60
DomainAAA

ABCA2 ABCC9 ABCC8 DNAH8 DYNC1H1

2.47e-031441215SM00382
DomainAAA+_ATPase

ABCA2 ABCC9 ABCC8 DNAH8 DYNC1H1

2.47e-031441215IPR003593
DomainABC_transporter_CS

ABCA2 ABCC9 ABCC8

2.53e-03421213IPR017871
DomainRan_BP1

RGPD8 RGPD5

2.63e-03121212PF00638
DomainRANBD1

RGPD8 RGPD5

2.63e-03121212PS50196
DomainRanBD

RGPD8 RGPD5

3.10e-03131212SM00160
DomainRan_bind_dom

RGPD8 RGPD5

3.10e-03131212IPR000156
DomainDynein_heavy_dom-2

DNAH8 DYNC1H1

3.60e-03141212IPR013602
DomainDHC_N2

DNAH8 DYNC1H1

3.60e-03141212PF08393
DomainATPase_dyneun-rel_AAA

DNAH8 DYNC1H1

3.60e-03141212IPR011704
DomainAnticodon-bd

BRIX1 GARS1

3.60e-03141212IPR004154
DomainAAA_5

DNAH8 DYNC1H1

3.60e-03141212PF07728
DomainABC_tran

ABCA2 ABCC9 ABCC8

3.71e-03481213PF00005
DomainABC_TRANSPORTER_2

ABCA2 ABCC9 ABCC8

3.71e-03481213PS50893
DomainABC_TRANSPORTER_1

ABCA2 ABCC9 ABCC8

3.93e-03491213PS00211
DomainABC_transporter-like

ABCA2 ABCC9 ABCC8

4.16e-03501213IPR003439
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MYBBP1A RGPD8 GRK5 U2SURP GARS1 SPG11 GPR101 PRPF8 ERBIN NOP14 STS SLC12A4 CCAR2 UGGT2 CFAP69 DNAH8 ATP2B3 ZNF541 RGPD5

1.28e-0614421271935575683
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MYBBP1A IPO7 UBE4B HACD3 U2SURP GARS1 PRPF8 ERBIN HIRA RIF1 JUP NOP14 PSME4 CCAR2 DDX60L EXOC2 DYNC1H1 KIF2C

2.19e-0613531271829467282
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

USP34 ABCA2 UBE4B ATP13A1 GRK5 NLRX1 GRB10 SIL1 HIRA RADIL PSME4 SLC12A4 NF2 ZER1 ESPL1 DYNC1H1

2.91e-0611051271635748872
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

BRIX1 MYBBP1A IPO7 HACD3 ATP13A1 DGKE SPG11 SLC39A10 PRPF8 ERBIN JUP NOP14 NF2 EHMT2 LRRC1 OS9 UGGT2 ESPL1

8.04e-0614871271833957083
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

USP34 PITRM1 ATP13A1 SLC26A2 NLRX1 SPG11 ATP8B2 OSTC RIF1 SLC12A4 PEX2 CCAR2 UGGT2 SLC25A52 ADGRA3

8.08e-0610611271533845483
Pubmed

Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells.

ERBIN NF2

1.32e-052127215659388
Pubmed

Protein 4.2 interaction with hereditary spherocytosis mutants of the cytoplasmic domain of human anion exchanger 1.

SLC4A1 EPB42

1.32e-052127221039340
Pubmed

Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity.

ABCC9 ABCC8

1.32e-052127226181369
Pubmed

A distinct mechanism for coactivator versus corepressor function by histone methyltransferase G9a in transcriptional regulation.

ESR1 EHMT2

1.32e-052127221984853
Pubmed

Correlation of body mass index and menopausal status with the intra-tumoral estrogen system in invasive breast cancer.

ESR1 STS

1.32e-052127219347708
Pubmed

SLC25A51 is a mammalian mitochondrial NAD+ transporter.

SLC25A51 SLC25A52

1.32e-052127232906142
Pubmed

Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes.

ABCC9 ABCC8

1.32e-052127222844491
Pubmed

TRAC variants associate with IgA nephropathy.

TRA TRAC

1.32e-052127219470682
Pubmed

The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia.

TRA TRAC

1.32e-05212723875483
Pubmed

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice.

ABCC9 ABCC8

1.32e-052127233529173
Pubmed

Estrogen responsiveness of the TFIID subunit TAF4B in the normal mouse ovary and in ovarian tumors.

ESR1 TAF4B

1.32e-052127224068106
Pubmed

Modulation of estrogen receptor alpha protein level and survival function by DBC-1.

ESR1 CCAR2

1.32e-052127217473282
Pubmed

A structural basis for immunodominant human T cell receptor recognition.

TRA TRAC

1.32e-052127212796775
Pubmed

Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation.

GPR101 CX3CR1

1.32e-052127236400250
Pubmed

Elevated expression of Erbin destabilizes ERα protein and promotes tumorigenesis in hepatocellular carcinoma.

ESR1 ERBIN

1.32e-052127228192186
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

BRIX1 EXOSC9 MYBBP1A U2SURP GARS1 SLC39A10 PRPF8 CWC22 ERBIN RIF1 JUP NOP14 CCAR2 KIF2C

1.63e-059891271436424410
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

BRIX1 EXOSC9 MYBBP1A IPO7 PITRM1 HACD3 ATP13A1 U2SURP GARS1 PRPF8 CWC22 RIF1 JUP CCAR2 ATP2B3 DYNC1H1 ADGRA3

1.77e-0514251271730948266
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UBE4B GRB10 SLC39A10 ERBIN GCC2 CCAR2 LRRC7 HERC3 DYNC1H1

1.98e-05407127912693553
Pubmed

Defining the membrane proteome of NK cells.

MYBBP1A ABCA2 IPO7 ATP13A1 DGKE PRPF8 CNOT6 NOP14 NF2 MAP4K1 GCC2 PEX2 EXOC2 DYNC1H1 KIF2C

2.48e-0511681271519946888
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

EXOSC9 MYBBP1A PITRM1 GARS1 ATG2B DGKE PRPF8 CNOT6 RIF1 POMP GCC2 CCAR2 UGGT2 EXOC2 DYNC1H1 KIF2C

2.66e-0513211271627173435
Pubmed

The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ERα and enhances ERα target gene expression in breast cancer cells.

ESR1 CCAR2

3.96e-053127230597111
Pubmed

The mitochondrial NAD+ transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions.

SLC25A51 SLC25A52

3.96e-053127235932995
Pubmed

Associations of protein 4.2 with band 3 and ankyrin.

SLC4A1 EPB42

3.96e-053127216718373
Pubmed

Functional roles of KATP channel subunits in metabolic inhibition.

ABCC9 ABCC8

3.96e-053127223624089
Pubmed

A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.

ABCC9 ABCC8

3.96e-05312728630239
Pubmed

Estradiol acts directly on bone marrow myeloid progenitors to differentially regulate GM-CSF or Flt3 ligand-mediated dendritic cell differentiation.

ESR1 CX3CR1

3.96e-053127218178810
Pubmed

Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.

SPG11 AP5B1

3.96e-053127223825025
Pubmed

Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro.

DYNC2LI1 DYNC1H1

3.96e-053127221723285
Pubmed

Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells.

SLC4A1 EPB42

3.96e-053127225778531
Pubmed

Identification of a band-3 binding site near the N-terminus of erythrocyte membrane protein 4.2.

SLC4A1 EPB42

3.96e-05312727626035
Pubmed

The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance.

TRA TRAC

3.96e-053127212429093
Pubmed

Coassociation of estrogen receptor and p160 proteins predicts resistance to endocrine treatment; SRC-1 is an independent predictor of breast cancer recurrence.

MYBBP1A ESR1

3.96e-053127219276281
Pubmed

Protein 4.2 binds to the carboxyl-terminal EF-hands of erythroid alpha-spectrin in a calcium- and calmodulin-dependent manner.

SLC4A1 EPB42

3.96e-053127220007969
Pubmed

LAP proteins are localized at the post-synaptic membrane of neuromuscular junctions and appear to modulate synaptic morphology and transmission.

ERBIN LRRC1

3.96e-053127227321929
Pubmed

Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry.

ESR1 DROSHA

3.96e-053127227380242
Pubmed

A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane.

SLC4A1 EPB42

3.96e-053127212531814
Pubmed

ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2.

CBFA2T3 CX3CR1

3.96e-053127224980046
Pubmed

Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice.

GARS1 DYNC1H1

3.96e-053127219593442
Pubmed

Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line.

TRA TRAC

3.96e-05312723873654
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

SIN3B MYBBP1A IPO7 ATG2B PRPF8 JUP DYNC1H1

4.55e-05256127733397691
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

TRA ESR1 GRK5 ABCC9 FBXO47 SLC4A1 RADIL UBXN11 MALRD1 LRRC7 ACKR2 DDX60L

4.59e-058141271223251661
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

MYBBP1A IPO7 HACD3 PRPF8 ERBIN RIF1 LRRC1 CCAR2 TAF4B DYNC1H1

5.09e-055731271028330616
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

USP34 IPO7 PITRM1 HACD3 PRPF8 SIL1 LRRC1 PEX2 TXNDC16 OS9 CCAR2 ESPL1 KIF2C

6.04e-059741271328675297
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

BRIX1 MYBBP1A HACD3 ATP13A1 ATG2B PRPF8 DYNC1H1

6.07e-05268127733024031
Pubmed

Drug-inducible gene recombination by the Dppa3-MER Cre MER transgene in the developmental cycle of the germ cell lineage in mice.

ESR1 ALPL

7.90e-054127221525417
Pubmed

Lano, a novel LAP protein directly connected to MAGUK proteins in epithelial cells.

ERBIN LRRC1

7.90e-054127211440998
Pubmed

Assembly limits the pharmacological complexity of ATP-sensitive potassium channels.

ABCC9 ABCC8

7.90e-054127211825905
Pubmed

Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis.

ESR1 STS

7.90e-054127217454161
Pubmed

Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium.

ABCC9 ABCC8

7.90e-054127212356945
Pubmed

Expression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heart.

ABCC9 ABCC8

7.90e-054127216085792
Pubmed

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.

ABCA2 ABCC8

7.90e-054127210639163
Pubmed

Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway.

ESPL1 ALPL

7.90e-054127226858254
Pubmed

A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.

ABCC9 ABCC8

7.90e-05412728798681
Pubmed

G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.

ESR1 EHMT2

7.90e-054127226960573
Pubmed

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

RGPD8 RGPD5

7.90e-05412729480752
Pubmed

Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1.

DNAH8 DYNC1H1

7.90e-054127215762842
Pubmed

Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons.

ABCC9 ABCC8

7.90e-054127210022826
Pubmed

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.

ABCC9 ABCC8

7.90e-054127228842488
Pubmed

Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα.

ESR1 CX3CR1

7.90e-054127225373903
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

EXOSC9 MYBBP1A HACD3 GARS1 NF2 APEX2 GCC2 LRRC1 TAF4B

9.10e-05496127931343991
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

BRIX1 EXOSC9 MYBBP1A HACD3 PRPF8 RIF1 NOP14 DROSHA CCAR2 ESPL1 KIF2C

1.12e-047591271135915203
Pubmed

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.

HACD3 ATP13A1 SLC39A10 FADS3 OS9 LRRC7 TARBP1

1.13e-04296127734186245
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

BRIX1 MYBBP1A RGPD8 PITRM1 HACD3 GARS1 ATG2B DGKE GPAM SLC25A51 NOP14 EHMT2 CCAR2 FASTKD3 ESPL1 KIF2C

1.15e-0414961271632877691
Pubmed

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.

MYBBP1A IPO7 U2SURP PSME4 CCAR2 DYNC1H1

1.30e-04211127617314511
Pubmed

Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.

UBE4B HERC3

1.31e-045127222124266
Pubmed

A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.

SPG11 AP5B1

1.31e-045127220613862
Pubmed

Transcriptional repression by leukaemia-associated ETO family members can be independent of oligomerization and coexpressed hSIN3B and N-CoR.

SIN3B CBFA2T3

1.31e-045127218586123
Pubmed

Repression of estrogen receptor beta function by putative tumor suppressor DBC1.

ESR1 CCAR2

1.31e-045127220074560
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

USP34 MYBBP1A PCDHB2 SLC39A10 ERBIN RIF1 NF2 EHMT2 GCC2 CCAR2 DYNC1H1

1.37e-047771271135844135
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

BRIX1 USP34 MYBBP1A IPO7 U2SURP PRPF8 RIF1 NOP14 CCAR2 DYNC1H1

1.49e-046531271022586326
Pubmed

Ankyrin-B regulates Kir6.2 membrane expression and function in heart.

ABCC9 ABCC8

1.97e-046127220610380
Pubmed

Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.

ACKR2 CX3CR1

1.97e-046127210702689
Pubmed

Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer.

ESR1 STS

1.97e-046127219551860
Pubmed

Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration.

FASTK FASTKD3

1.97e-046127220869947
Pubmed

p300-mediated acetylation stabilizes the Th-inducing POK factor.

MYBBP1A PRPF8

1.97e-046127220810990
Pubmed

A novel ENU-induced ankyrin-1 mutation impairs parasite invasion and increases erythrocyte clearance during malaria infection in mice.

SLC4A1 EPB42

1.97e-046127227848995
Pubmed

Identification of Erbin interlinking MuSK and ErbB2 and its impact on acetylcholine receptor aggregation at the neuromuscular junction.

ERBIN LRRC1

1.97e-046127220463225
Pubmed

Nuclear Functions of Nucleolin through Global Proteomics and Interactomic Approaches.

BRIX1 EXOSC9 MYBBP1A U2SURP PRPF8

1.99e-04145127527049334
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

USP34 EXOSC9 IPO7 HACD3 DGKE PRPF8 ERBIN HIRA POMP OS9 CCAR2 DDX60L EXOC2 DYNC1H1 ALPL

2.53e-0414401271530833792
Pubmed

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

PRPF8 JUP CCAR2 DYNC1H1

2.61e-0484127429563501
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

BRIX1 MYBBP1A IPO7 U2SURP PRPF8 BARX1 DYNC1H1

2.63e-04340127729478914
Pubmed

Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3.

SLC4A1 EPB42

2.75e-04712722968981
Pubmed

Trim58 degrades Dynein and regulates terminal erythropoiesis.

DYNC2LI1 DYNC1H1

2.75e-047127225241935
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD8 RGPD5

2.75e-047127215710750
Pubmed

Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing.

RIF1 EHMT2

2.75e-047127224735877
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

MYBBP1A GRK5 U2SURP CWC22 JUP

2.79e-04156127522952844
Pubmed

Host PDZ-containing proteins targeted by SARS-CoV-2.

ERBIN RADIL LRRC7

2.86e-0435127333864728
Pubmed

Phosphoproteomic analysis of the developing mouse brain.

USP34 MYBBP1A UBE4B HACD3 GRB10 CCAR2

2.98e-04246127615345747
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

MYBBP1A IPO7 U2SURP PRPF8 RIF1 LRRC1 EXOC2 DYNC1H1 KIF2C

2.99e-04582127920467437
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

BRIX1 MYBBP1A HACD3 U2SURP GARS1 PRPF8 CWC22 DROSHA CCAR2 DYNC1H1

3.03e-047141271028302793
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

SIN3B CBFA2T3 PRPF8 HIRA RIF1 NOP14 CCAR2 BARX1 ATP2B3 DYNC1H1 KIF2C

3.18e-048571271125609649
Pubmed

Fetal CCL2 signaling mediates offspring social behavior and recapitulates effects of prenatal stress.

LBP CX3CR1

3.65e-048127237914098
Pubmed

Architecture of the human erythrocyte ankyrin-1 complex.

SLC4A1 EPB42

3.65e-048127235835865
Pubmed

HIV-1 uncoating is facilitated by dynein and kinesin 1.

DYNC2LI1 DYNC1H1

3.65e-048127225231297
Pubmed

A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex.

SLC25A51 EHMT2 SLC25A52

3.65e-0438127332541003
InteractionHCST interactions

NLRX1 SPG11 SLC39A10 ATP8B2 SLC25A51 GPD1L RADIL AP5B1 FASTKD3 TARBP1

5.68e-0720512410int:HCST
InteractionBSG interactions

MYBBP1A IPO7 NLRX1 GARS1 PRPF8 GPD1L RIF1 DYNC2LI1 GCC2 OS9 EXOC2 FASTKD3 CFAP69 ATP2B3 TARBP1

7.86e-0663112415int:BSG
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESR1 GPAM XRCC3 SLC12A4 APEX2 ALPL KIF2C

7.49e-0717612773766e0533b103ec92ac75eba3df02e287efc53fa
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESR1 GPAM XRCC3 SLC12A4 APEX2 ALPL KIF2C

7.49e-071761277aa1bada2175d8370fc71939a607407155259d195
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ABCC9 CCDC81 TRAC LRRC19 UGGT2 DNAH8

5.77e-061561276a5930b455e5c8586c43c50106ab4d8a1e5e9e3d6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ESR1 GRK5 RADIL LRFN5 PODN LRRC7

9.76e-0617112765d31fc9b60329d4ae3c77e4ca679359d9314397d
DrugSC-560; Up 200; 10uM; MCF7; HT_HG-U133A

USP34 GLB1L ESR1 GRK5 NLRX1 DGKE NF2 HERC3 CFAP69

1.81e-0619912796870_UP
DiseaseElliptocytosis found

SLC4A1 EPB42

1.01e-0441222C0427480
DiseaseWallerian Degeneration

UBE4B CCAR2

1.01e-0441222C0043020
Diseasehereditary spherocytosis (is_implicated_in)

SLC4A1 EPB42

1.68e-0451222DOID:12971 (is_implicated_in)
DiseaseHereditary spherocytosis

SLC4A1 EPB42

1.68e-0451222cv:C0037889
DiseaseAnemia, hereditary spherocytic hemolytic

SLC4A1 EPB42

1.68e-0451222C0221409
Diseasephosphatidylcholine measurement

GPAM CNOT6 BLK MALRD1 FADS3 ABCC8 DYNC1H1

1.85e-042841227EFO_0010226
DiseaseElliptocytosis, Hereditary

SLC4A1 EPB42

2.52e-0461222C0013902
DiseaseHereditary spherocytosis

SLC4A1 EPB42

4.67e-0481222C0037889
Diseasephysical activity

ESR1 ABCC9 FBXO47 LRRC7

4.96e-04881224EFO_0003940
DiseaseAcute Confusional Migraine

ESR1 TRPM8

5.99e-0491222C0521664
DiseaseStatus Migrainosus

ESR1 TRPM8

5.99e-0491222C0338489
DiseaseCCL17 measurement

GRK5 ACKR2

5.99e-0491222EFO_0009414
DiseaseAbdominal Migraine

ESR1 TRPM8

5.99e-0491222C0270858
DiseaseSick Headaches

ESR1 TRPM8

5.99e-0491222C0700438
Diseasepropionylcarnitine measurement

MALRD1 TAF4B

5.99e-0491222EFO_0020942
DiseaseCervical Migraine Syndrome

ESR1 TRPM8

5.99e-0491222C0007852
DiseaseHemicrania migraine

ESR1 TRPM8

5.99e-0491222C0018984
DiseaseMesothelioma

ESR1 XRCC3 NF2

6.55e-04411223C0025500
Diseasesciatic neuropathy (biomarker_via_orthology)

ABCC9 KCNC4 ABCC8 CX3CR1

7.73e-04991224DOID:11446 (biomarker_via_orthology)
DiseaseHIV Infections

IPO7 PRPF8 PSME4 CX3CR1

8.97e-041031224C0019693
DiseaseHIV Coinfection

IPO7 PRPF8 PSME4 CX3CR1

8.97e-041031224C4505456
Diseasecryptorchidism (biomarker_via_orthology)

ESR1 STS

9.10e-04111222DOID:11383 (biomarker_via_orthology)
DiseaseC-C motif chemokine 17 measurement

GRK5 ACKR2

1.09e-03121222EFO_0008045
Diseaseurate measurement

USP34 LINC00862 U2SURP CCDC81 XRCC3 SLC4A1 MALRD1 FADS3 AP5B1 UGGT2 HERC3

1.24e-0389512211EFO_0004531
DiseaseMigraine Disorders

ESR1 TRPM8

1.28e-03131222C0149931
DiseaseMetabolic Bone Disorder

ESR1 ALPL

1.49e-03141222C0005944
Diseasechromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)

PI4KAP2 HIRA

1.49e-03141222DOID:0060413 (implicated_via_orthology)
DiseaseMaturity onset diabetes mellitus in young

BLK ABCC8

1.49e-03141222C0342276
DiseaseOsteopenia

ESR1 ALPL

1.72e-03151222C0029453
Diseasemelanoma

CBFA2T3 JUP TRPM8 EXOC2

1.89e-031261224EFO_0000756
DiseaseMalaria, susceptibility to

CR1 SLC4A1

1.96e-03161222cv:C1970028
Disease

CR1 SLC4A1

1.96e-03161222611162
DiseaseMonogenic diabetes

BLK ABCC8

1.96e-03161222C3888631
Diseasesex interaction measurement, ulcerative colitis

EHMT2 OS9

2.21e-03171222EFO_0000729, EFO_0008343
DiseaseCharcot-Marie-Tooth disease type 2

GARS1 DYNC1H1

2.21e-03171222cv:C0270914
Diseasecarcinoma (implicated_via_orthology)

BLK JUP LRRC1

2.39e-03641223DOID:305 (implicated_via_orthology)
Diseasephosphatidylcholine 36:4 measurement

SIL1 FADS3

2.48e-03181222EFO_0010382
Diseasetotal blood protein measurement

LINC00862 ESR1 DGKE CBFA2T3 SLC4A1 CC2D2B BLK

2.70e-034491227EFO_0004536
Diseaseascending aortic diameter

ESR1 ABCC9 CBFA2T3 ABCC8

2.77e-031401224EFO_0021787
DiseaseMalaria

CR1 SLC4A1

3.07e-03201222C0024530
DiseaseLiver diseases

GRK5 JUP ALPL

3.34e-03721223C0023895
DiseaseLiver Dysfunction

GRK5 JUP ALPL

3.34e-03721223C0086565
DiseaseBREAST CANCER

ESR1 XRCC3

3.38e-03211222114480
Diseasein situ carcinoma (is_marker_for)

ESR1 ALPL

3.38e-03211222DOID:8719 (is_marker_for)
Diseaseaortic measurement

ESR1 ABCC9 CBFA2T3 BLK ABCC8

3.96e-032511225EFO_0020865
Diseaseobsolete Mendelian syndromes with cleft lip/palate

TXNDC16 LRRC7

4.05e-03231222MONDO_0015335
Diseasephosphatidylserines measurement

FADS3 CFAP69

4.05e-03231222EFO_0020049
Diseaseplatelet-to-lymphocyte ratio

EXOSC9 GRK5 NLRX1 XRCC3 SLC4A1 CX3CR1

4.07e-033631226EFO_0008446

Protein segments in the cluster

PeptideGeneStartEntry
RFQQNLLGFLLPLLA

ACKR2

211

O00590
VFFQLSVVKGRLPQL

CCAR2

76

Q8N163
EFLPANFGRLTKLQI

ERBIN

151

Q96RT1
RKQLLLGQFTLLFNP

EPB42

126

P16452
FLFRQLLLATQGGPK

ADAD2

296

Q8NCV1
SGIQLFDRILLLFKP

SLC4A1

801

P02730
GVLDRFSQIQPKLIF

AACS

191

Q86V21
LQLIAFRNGKLFPAT

ADGRA3

636

Q8IWK6
LADRVLQFFLGTPKL

ATP13A1

1186

Q9HD20
EIGPRFVLNLIKIFQ

BRIX1

231

Q8TDN6
RNVETNFLGFLLPLL

CX3CR1

191

P49238
RLLQEFNKIEPPLIF

EHMT2

1001

Q96KQ7
LGVRFLQPFVNLLSK

ABCC9

211

O60706
NLLNKIILGPIRFFD

ABCC9

1071

O60706
EFAGTQLKILRFLVP

APEX2

331

Q9UBZ4
TFILRQILPKLEFGI

CC2D2B

1341

Q6DHV5
ALLGFVLDLKRDFQP

ATP2B3

546

Q16720
PLRLNIDQDALFFLK

ATG2B

1706

Q96BY7
PVARLLRENFIFKII

AGBL1

826

Q96MI9
PGQLNLLFNKREFFI

ATP8B2

961

P98198
NIPKLNRFLLLFIGF

OSTC

111

Q9NRP0
LLQFIFLKPGSERER

RGPD5

1716

Q99666
LLQFIFLKPGSERER

RGPD8

1716

O14715
PKQRQVLIFFVLLGI

PCDHB2

11

Q9Y5E7
ALLKFNFQRNIPGIR

LRFN5

431

Q96NI6
FQPGTFGQLLLKIAR

RADIL

451

Q96JH8
VVQKLVLPFGRLNYL

FASTK

276

Q14296
PNLKGIFLRFNKLAV

PODN

546

Q7Z5L7
PLLKRVQLYDLGLQI

LBP

451

P18428
ILPFVQVKGNFARLQ

M1AP

76

Q8TC57
PSLIQLLGRNFILFI

HACD3

216

Q9P035
EFLPANFGRLVKLRI

LRRC7

151

Q96NW7
GLLFKELLQTPNFRI

GPD1L

176

Q8N335
LRGRKTFLIPVLFNN

HERC3

571

Q15034
LKIPEFIGRFQNLIV

LRRC39

96

Q96DD0
FPQIGELILKRLILN

CWC22

226

Q9HCG8
LLKFGVQALLAARPF

BARX1

56

Q9HBU1
LLLKIRGVINQLAFG

DYNC2LI1

226

Q8TCX1
PSNLVFVNFLKRGLF

DDX60L

1431

Q5H9U9
IAVAFPGNLQLIFIL

MCF2L2

121

Q86YR7
PKLNRATEGILFFNL

EXOSC9

66

Q06265
VLQRFKFLFNLPLNI

EXOC2

276

Q96KP1
KLLFAPNLLLDRNQG

ESR1

401

P03372
ILPAFILLFNGLKRA

IPO7

861

O95373
PLLACLLGKQFQQIR

LPO

626

P22079
LKLGGLINFLIFLQR

PEX2

146

P28328
LQRFQKLNIPCLGLE

DNAH8

461

Q96JB1
ALFKPQLVRLLGTAQ

AP5B1

306

Q2VPB7
FVGNIVLALVLQRKP

GPR101

46

Q96P66
LLFNLIKVVPRVFGR

NLRX1

551

Q86UT6
FVIPFLKANLPLLQR

CBFA2T3

231

O75081
QRFIPELINFLLGIL

NOP14

606

P78316
VRLNYGIPAIVKLLN

JUP

476

P14923
LPEQFFQLVKLRKLG

LRRC1

51

Q9BTT6
FRLLGAALPLLTKEQ

MYBBP1A

306

Q9BQG0
GFLAQEELLPKRVIN

NF2

161

P35240
IIKGNLFEPVVNALL

PPP4R3C

576

Q6ZMV5
TLRNIQGLFAPLKLQ

POMP

66

Q9Y244
AIQILRKNPKGFFLL

ALPL

316

P05186
LLGKLRNFEVIFQGI

MALRD1

1641

Q5VYJ5
LQIPRQCALFLVLKG

ESPL1

1021

Q14674
LFPLNLQLGAKVSFV

CR1

1271

P17927
VGNNKFILIQRPVFI

CCDC81

66

Q6ZN84
RQLLAPINKAGSFLI

BLK

136

P51451
NVLLQFIFLKPGSER

GCC2

1621

Q8IWJ2
FLLFPRGALNKITLL

GLB1L

591

Q6UWU2
IPLVLFFILLGLRQK

ABCA2

31

Q9BZC7
TLGAPKNNRILIFID

DNAH14

1916

Q0VDD8
FGNFKALPLEIFQII

FBXO47

41

Q5MNV8
KNLESALRFGNPLLV

DYNC1H1

3621

Q14204
IIKQQGLVDGLFLLR

GRB10

506

Q13322
LNRGFARLKALVPFL

FIGLA

81

Q6QHK4
LLGEFRILLNPVQVF

DGKE

236

P52429
LLKELLPVIGQNLRF

HIRA

986

P54198
LCDKQPIGRLLFRQF

GRK5

56

P34947
GLPLRDLAQIFKILN

CFAP69

81

A5D8W1
LNFVRKFLQPLLIGE

FADS3

81

Q9Y5Q0
ILVPIINQGCFKFLL

SLC39A10

426

Q9ULF5
INPFLKRNGGFVELL

RXYLT1

211

Q9Y2B1
SLQARLFPGLAIKIQ

KIF2C

6

Q99661
ERLPIIFNKVLFNEG

C1QTNF7

161

Q9BXJ2
NNLLRVLPFELGKLF

CNOT6

106

Q9ULM6
VLPFELGKLFQLQTL

CNOT6

111

Q9ULM6
GNFLRKILQPALDLL

PRIMPOL

186

Q96LW4
FVPLRSLKLLNLQGN

LRRC19

141

Q9H756
KRADLQLPLFLLFLG

OR8A1

36

Q8NGG7
NKFLLVRQVLFPLPT

MAP4K1

641

Q92918
DEPFLFIGALQKRIL

TAF4B

651

Q92750
KQLFGRLLFNDPDLR

DROSHA

1061

Q9NRR4
RLQALGLQLFVKDPA

AGXT

301

P21549
ILNGTPALFLIQLIF

RIF1

576

Q5UIP0
LVPILFRNGLSNVLF

SLC25A51

176

Q9H1U9
NKLILLLGIVFFERG

OVCH2

6

Q7RTZ1
LAKIFKPLFLQRLQG

FASTKD3

466

Q14CZ7
QFITFLQRLLGPLLE

GPAM

716

Q9HCL2
LNFKRLLEFNQGKLP

GARS1

306

P41250
PVELLKLGNQLAKFR

PITRM1

461

Q5JRX3
GFKRLVFLPLQIVGV

STS

181

P08842
FGNILILLFLKSPAQ

LINC00862

61

A6NCI5
EGFLLKPVFLQRNLK

SIN3B

1006

O75182
QFLKLGGLQVLRTLV

SIL1

306

Q9H173
LVPILFRNGLSNVLF

SLC25A52

176

Q3SY17
KNIFQLVGLDLFVFP

PI4KAP2

356

A4QPH2
RNLKEIFFNILVPGA

OS9

616

Q13438
LPCLQNIFGVILFLR

SLC12A4

126

Q9UP95
ARLLVDSILQGFKPQ

SLFNL1

281

Q499Z3
VIGFRILLLKVAGFN

TRAC

116

P01848
PFLIKLQNIFLGLVN

U2SURP

666

O15042
QDLGVRFLQPFVNLL

ABCC8

211

Q09428
AIFIFNPRTGQLFLK

PRPF8

1806

Q6P2Q9
LIRGFQLFFKDSPLL

SPG11

1536

Q96JI7
FRLQKPLLILFSDGT

TXNDC16

626

Q9P2K2
ALKRPLQFLGLFENS

ZER1

321

Q7Z7L7
NLQIKPGIKIFRFVA

SLC26A2

571

P50443
VIGFRILLLKVAGFN

TRA

251

P0DTU3
FKEQLLQEPRLFLGL

REXO5

611

Q96IC2
FKQIFIPILQGLALA

UBE4B

516

O95155
FLIIKIIGDLLQFQG

PSME4

891

Q14997
VFPGLFLLSKNTLQR

TLCD3B

11

Q71RH2
IPLFFLELAVGQRIR

SLC6A17

111

Q9H1V8
LLVLFPRLDQNFLNG

TARBP1

1176

Q13395
LRLLPKLFGTFQQFG

USP34

921

Q70CQ2
PKFVRLFLENGLNLR

TRPM8

471

Q7Z2W7
LQVRFKIQPGDARLF

UGGT2

366

Q9NYU1
VPYLEAQKGQFLRLL

SIGLEC10

261

Q96LC7
PGELLQKLRFGSQIF

XRCC3

166

O43542
EKFLNRLPKFVIRQG

UBXN11

331

Q5T124
PLFRQLFLKSQEPLV

ZNF541

536

Q9H0D2
KNLLNIIDFVAILPF

KCNC4

311

Q03721