Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncyclosporin A binding

PPIAL4C PPIAL4E PPIAL4H PPIAL4A PPIAL4G PPIC PPIAL4F

2.14e-1224737GO:0016018
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

PPIAL4C PPIAL4E PPIAL4H PPIAL4A PPIAL4G PPIC PPIAL4F

5.73e-1050737GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

PPIAL4C PPIAL4E PPIAL4H PPIAL4A PPIAL4G PPIC PPIAL4F

8.76e-1053737GO:0016859
GeneOntologyMolecularFunctionamide binding

PPIAL4C IGF1R PPIAL4E PPIAL4H INSR PPIAL4A PPIAL4G CERT1 PPIC PPIAL4F

1.32e-072997310GO:0033218
GeneOntologyMolecularFunctionisomerase activity

BLM PPIAL4C PPIAL4E PPIAL4H PPIAL4A PPIAL4G PPIC PPIAL4F

4.98e-07192738GO:0016853
GeneOntologyMolecularFunctioninsulin receptor activity

IGF1R INSR

3.95e-053732GO:0005009
GeneOntologyMolecularFunctioninsulin binding

IGF1R INSR

1.31e-045732GO:0043559
GeneOntologyMolecularFunctionbeta-galactosidase activity

GBA3 GLB1L2

1.31e-045732GO:0004565
GeneOntologyMolecularFunctiongalactosidase activity

GBA3 GLB1L2

2.74e-047732GO:0015925
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase binding

MET IGF1R INSR

5.21e-0443733GO:0043548
GeneOntologyMolecularFunctioninsulin-like growth factor I binding

IGF1R INSR

1.00e-0313732GO:0031994
GeneOntologyMolecularFunctioninsulin receptor substrate binding

IGF1R INSR

1.34e-0315732GO:0043560
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

MET IGF1R INSR

1.74e-0365733GO:0004714
GeneOntologyMolecularFunctioninsulin-like growth factor binding

IGF1R INSR

2.17e-0319732GO:0005520
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

PPIAL4C PPIAL4E PPIAL4H PPIAL4A PPIAL4G PPIC PPIAL4F

4.90e-1138717GO:0000413
GeneOntologyBiologicalProcesspeptidyl-proline modification

PPIAL4C PPIAL4E PPIAL4H PPIAL4A PPIAL4G PPIC PPIAL4F

6.58e-1054717GO:0018208
GeneOntologyBiologicalProcessprotein folding

PPIAL4C PPIAL4E PPIAL4H PPIAL4A PPIAL4G PPIC PPIAL4F

2.19e-05246717GO:0006457
GeneOntologyBiologicalProcesspeptidyl-amino acid modification

MET PPIAL4C IGF1R PPIAL4E PPIAL4H INSR PPIAL4A PPIAL4G PPIC NOS2 PPIAL4F NAA16

1.14e-049767112GO:0018193
GeneOntologyCellularComponentinsulin receptor complex

IGF1R INSR

7.38e-054742GO:0005899
DomainCyclophilin-type_PPIase_CS

PPIAL4C PPIAL4A PPIAL4G PPIC PPIAL4F

7.67e-0919715IPR020892
DomainCyclophilin-type_PPIase

PPIAL4C PPIAL4A PPIAL4G PPIC PPIAL4F

1.34e-0821715IPR024936
DomainCyclophilin-like_dom

PPIAL4C PPIAL4A PPIAL4G PPIC PPIAL4F

1.72e-0822715IPR029000
DomainCSA_PPIASE_2

PPIAL4C PPIAL4A PPIAL4G PPIC PPIAL4F

1.72e-0822715PS50072
DomainPro_isomerase

PPIAL4C PPIAL4A PPIAL4G PPIC PPIAL4F

1.72e-0822715PF00160
Domain-

PPIAL4C PPIAL4A PPIAL4G PPIC PPIAL4F

1.72e-08227152.40.100.10
DomainCyclophilin-type_PPIase_dom

PPIAL4C PPIAL4A PPIAL4G PPIC PPIAL4F

1.72e-0822715IPR002130
DomainCSA_PPIASE_1

PPIAL4C PPIAL4A PPIAL4G PPIC PPIAL4F

1.72e-0822715PS00170
DomainTyr_kinase_insulin-like_rcpt

IGF1R INSR

4.26e-053712IPR016246
DomainFurin-like

IGF1R INSR

2.96e-047712PF00757
DomainRcpt_L-dom

IGF1R INSR

2.96e-047712IPR000494
DomainFurin-like_Cys-rich_dom

IGF1R INSR

2.96e-047712IPR006211
DomainRecep_L_domain

IGF1R INSR

2.96e-047712PF01030
Domain-

IGF1R INSR

2.96e-0477123.80.20.20
DomainPNT

FLI1 ERG

7.66e-0411712PS51433
DomainPointed_dom

FLI1 ERG

7.66e-0411712IPR003118
DomainSAM_PNT

FLI1 ERG

7.66e-0411712PF02198
DomainTyr_kinase_rcpt_2_CS

IGF1R INSR

7.66e-0411712IPR002011
DomainSAM_PNT

FLI1 ERG

7.66e-0411712SM00251
DomainRECEPTOR_TYR_KIN_II

IGF1R INSR

9.18e-0412712PS00239
DomainTPR

APPBP2 CNOT10 TTC13 NAA16

1.48e-03129714SM00028
DomainTPR_repeat

APPBP2 CNOT10 TTC13 NAA16

1.65e-03133714IPR019734
DomainTPR-like_helical_dom

APPBP2 SAMD9 CNOT10 TTC13 NAA16

1.93e-03233715IPR011990
DomainFurin_repeat

IGF1R INSR

2.10e-0318712IPR006212
DomainFU

IGF1R INSR

2.10e-0318712SM00261
DomainZINC_FINGER_C2H2_2

ZNF512B ZXDC ZNF596 ZNF335 PLAG1 PLAGL2 ZNF749 ZNF101 ZNF681

2.59e-03775719PS50157
DomainZINC_FINGER_C2H2_1

ZNF512B ZXDC ZNF596 ZNF335 PLAG1 PLAGL2 ZNF749 ZNF101 ZNF681

2.64e-03777719PS00028
DomainZnf_C2H2-like

ZNF512B ZXDC ZNF596 ZNF335 PLAG1 PLAGL2 ZNF749 ZNF101 ZNF681

3.10e-03796719IPR015880
DomainZnf_C2H2

ZNF512B ZXDC ZNF596 ZNF335 PLAG1 PLAGL2 ZNF749 ZNF101 ZNF681

3.34e-03805719IPR007087
DomainZnF_C2H2

ZNF512B ZXDC ZNF596 ZNF335 PLAG1 PLAGL2 ZNF749 ZNF101 ZNF681

3.42e-03808719SM00355
DomainC2H2_Znf_fam

PLAG1 PLAGL2

3.73e-0324712IPR027775
Domain-

ZXDC ZNF596 ZNF335 PLAG1 PLAGL2 ZNF749 ZNF101 ZNF681

4.14e-036797183.30.160.60
DomainTyrKc

MET IGF1R INSR

4.59e-0388713SM00219
DomainTyr_kinase_cat_dom

MET IGF1R INSR

4.59e-0388713IPR020635
DomainZnf_C2H2/integrase_DNA-bd

ZXDC ZNF596 ZNF335 PLAG1 PLAGL2 ZNF749 ZNF101 ZNF681

4.72e-03694718IPR013087
DomainTPR_1

CNOT10 TTC13 NAA16

4.88e-0390713PF00515
DomainTPR_1

CNOT10 TTC13 NAA16

4.88e-0390713IPR001440
DomainETS_DOMAIN_1

FLI1 ERG

5.05e-0328712PS00345
DomainETS_DOMAIN_2

FLI1 ERG

5.05e-0328712PS00346
DomainETS

FLI1 ERG

5.05e-0328712SM00413
DomainEts_dom

FLI1 ERG

5.05e-0328712IPR000418
DomainETS_DOMAIN_3

FLI1 ERG

5.05e-0328712PS50061
DomainEts

FLI1 ERG

5.05e-0328712PF00178
DomainPROTEIN_KINASE_TYR

MET IGF1R INSR

6.01e-0397713PS00109
DomainTyr_kinase_AS

MET IGF1R INSR

6.01e-0397713IPR008266
Domain-

BLM RABL6 NWD2 SAMD9 CLPB DDX23 RFC3 AK7

7.22e-037467183.40.50.300
Domain-

FLI1 SAMD9 ERG

7.68e-031067131.10.150.50
DomainLaminin_EGF

LAMA4 MEGF10

7.82e-0335712PF00053
DomainEGF_Lam

LAMA4 MEGF10

7.82e-0335712SM00180
Domain-

GBA3 GLB1L2

7.82e-03357123.20.20.80
Domain-

APPBP2 CNOT10 TTC13 NAA16

7.99e-032077141.25.40.10
DomainGlyco_hydro_catalytic_dom

GBA3 GLB1L2

9.17e-0338712IPR013781
Pubmed

Functional genetic approach identifies MET, HER3, IGF1R, INSR pathways as determinants of lapatinib unresponsiveness in HER2-positive gastric cancer.

MET IGF1R INSR

3.69e-08474324973425
Pubmed

A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II.

IGF1R INSR

4.47e-06274219139090
Pubmed

A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism.

MET INSR

4.47e-06274222081023
Pubmed

Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody.

IGF1R INSR

4.47e-06274222438913
Pubmed

Apolipoprotein C3 and circulating mediators of preadipocyte proliferation in states of lipodystrophy.

IGF1R INSR

4.47e-06274235964946
Pubmed

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.

IGF1R INSR

4.47e-06274212813019
Pubmed

Epigenetic DNA methylation in the promoters of the Igf1 receptor and insulin receptor genes in db/db mice.

IGF1R INSR

4.47e-06274221474992
Pubmed

Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling.

IGF1R INSR

4.47e-06274228050756
Pubmed

ERG and FLI1 protein expression in epithelioid sarcoma.

FLI1 ERG

4.47e-06274224072183
Pubmed

Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.

IGF1R INSR

4.47e-06274216642022
Pubmed

IGF1R Expression in Ovarian Granulosa Cells Is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice.

IGF1R INSR

4.47e-06274228407051
Pubmed

BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis.

IGF1R INSR

4.47e-06274226438154
Pubmed

Insulin and IGF-1 have both overlapping and distinct effects on CD4+ T cell mitochondria, metabolism, and function.

IGF1R INSR

4.47e-06274238383709
Pubmed

Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

IGF1R INSR

4.47e-06274223671263
Pubmed

Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis.

IGF1R INSR

4.47e-06274224809298
Pubmed

Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells.

MET IGF1R

4.47e-06274216891453
Pubmed

Suppression of Cardiac Autophagy by Hyperinsulinemia in Insulin Receptor-Deficient Hearts Is Mediated by Insulin-Like Growth Factor Receptor Signaling.

IGF1R INSR

4.47e-06274231088290
Pubmed

Expression of IGF-1R and iNOS in nasal polyps; epithelial cell homeostasis and innate immune mechanisms in pathogenesis of nasal polyposis.

IGF1R NOS2

4.47e-06274219381485
Pubmed

Development of a Quantitative PCR Assay for Detection of Human Insulin-Like Growth Factor Receptor and Insulin Receptor Isoforms.

IGF1R INSR

4.47e-06274226862994
Pubmed

Human microvascular endothelial cells are sensitive to IGF-I but resistant to insulin at the receptor level.

IGF1R INSR

4.47e-06274218708119
Pubmed

A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.

IGF1R INSR

4.47e-06274221139139
Pubmed

The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.

IGF1R INSR

4.47e-06274225758790
Pubmed

Role of insulin receptor in the regulation of glucose uptake in neonatal hepatocytes.

IGF1R INSR

4.47e-06274216644916
Pubmed

Synergistic Role of Endothelial ERG and FLI1 in Mediating Pulmonary Vascular Homeostasis.

FLI1 ERG

4.47e-06274228248553
Pubmed

The signaling potential of the receptors for insulin and insulin-like growth factor I (IGF-I) in 3T3-L1 adipocytes: comparison of glucose transport activity, induction of oncogene c-fos, glucose transporter mRNA, and DNA-synthesis.

IGF1R INSR

4.47e-0627421660482
Pubmed

Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7.

APPBP2 RCAN1

4.47e-06274225194880
Pubmed

Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.

IGF1R INSR

4.47e-06274225246545
Pubmed

Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells.

IGF1R INSR

4.47e-06274227384680
Pubmed

Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart.

IGF1R INSR

4.47e-06274235786404
Pubmed

Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD.

IGF1R INSR

4.47e-06274227207510
Pubmed

Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas.

IGF1R INSR

4.47e-06274228138037
Pubmed

Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function.

IGF1R INSR

4.47e-06274227207537
Pubmed

Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer?

MET IGF1R

4.47e-06274221729677
Pubmed

IGF1R depletion facilitates MET-amplification as mechanism of acquired resistance to erlotinib in HCC827 NSCLC cells.

MET IGF1R

4.47e-06274228418902
Pubmed

Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation.

IGF1R INSR

4.47e-06274230070361
Pubmed

Reduced insulin-like growth factor I receptor and altered insulin receptor isoform mRNAs in normal mucosa predict colorectal adenoma risk.

IGF1R INSR

4.47e-06274225017244
Pubmed

Differential expression of IGF-I and insulin receptor isoforms in HPV positive and negative human cervical cancer cell lines.

IGF1R INSR

4.47e-06274218711691
Pubmed

Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes.

IGF1R INSR

4.47e-06274231562314
Pubmed

Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma.

IGF1R INSR

4.47e-06274227088794
Pubmed

Insulin-like growth factor I receptors are more abundant than insulin receptors in human micro- and macrovascular endothelial cells.

IGF1R INSR

4.47e-06274214722023
Pubmed

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.

IGF1R INSR

4.47e-06274217416680
Pubmed

Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling.

IGF1R INSR

4.47e-06274222692545
Pubmed

Preclinical and first-in-human phase I studies of KW-2450, an oral tyrosine kinase inhibitor with insulin-like growth factor receptor-1/insulin receptor selectivity.

IGF1R INSR

4.47e-06274226850678
Pubmed

High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy.

IGF1R INSR

4.47e-06274221177763
Pubmed

Insulin, insulin receptor and insulin-like growth factor-I receptor on the human ocular surface.

IGF1R INSR

4.47e-06274212613967
Pubmed

Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes.

IGF1R INSR

4.47e-06274218693051
Pubmed

Signalling through the insulin receptor and the insulin-like growth factor-I receptor.

IGF1R INSR

4.47e-0627427821728
Pubmed

A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer.

IGF1R INSR

4.47e-06274221908557
Pubmed

The Ets family member Erg gene is expressed in mesodermal tissues and neural crests at fundamental steps during mouse embryogenesis.

FLI1 ERG

4.47e-06274210704859
Pubmed

Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function.

IGF1R INSR

4.47e-06274219817984
Pubmed

Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.

IGF1R INSR

4.47e-06274219744489
Pubmed

Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.

FLI1 ERG

4.47e-06274230500808
Pubmed

Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.

FLI1 ERG

4.47e-06274219666492
Pubmed

Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.

IGF1R INSR

4.47e-06274228065828
Pubmed

Transdifferentiation of erythroblasts to megakaryocytes using FLI1 and ERG transcription factors.

FLI1 ERG

4.47e-06274226063314
Pubmed

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.

IGF1R INSR

4.47e-06274230765523
Pubmed

Functional collaboration of insulin-like growth factor-1 receptor (IGF-1R), but not insulin receptor (IR), with acute GH signaling in mouse calvarial cells.

IGF1R INSR

4.47e-06274224302626
Pubmed

Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon.

IGF1R INSR

4.47e-06274226251471
Pubmed

Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis.

IGF1R INSR

4.47e-06274225981038
Pubmed

Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells.

IGF1R INSR

4.47e-06274222879999
Pubmed

Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling.

IGF1R INSR

4.47e-06274236548088
Pubmed

Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.

IGF1R INSR

4.47e-06274217189427
Pubmed

Differential effects of IGF-I, IGF-II and insulin in human preadipocytes and adipocytes--role of insulin and IGF-I receptors.

IGF1R INSR

4.47e-06274221524684
Pubmed

Met, IGF1R, and other new targets in upper GI malignancies.

MET IGF1R

4.47e-06274223873272
Pubmed

Insulin-like growth factor-1 receptor is associated with better prognosis in classical Hodgkin's lymphoma: Correlation with MET expression.

MET IGF1R

4.47e-06274225916750
Pubmed

[Effects of insulin on expression of insulin receptor and insulin-like growth factor-1 receptor and proliferation in Reh cells].

IGF1R INSR

4.47e-06274222541124
Pubmed

Insulin and IGF1 receptors in human cardiac microvascular endothelial cells: metabolic, mitogenic and anti-inflammatory effects.

IGF1R INSR

4.47e-06274222825921
Pubmed

A functional assessment of insulin/insulin-like growth factor-I hybrid receptors.

IGF1R INSR

4.47e-0627427895674
Pubmed

Insulin receptor and IGF1R are not required for oocyte growth, differentiation, and maturation in mice.

IGF1R INSR

4.47e-06274219851056
Pubmed

Combined and individual tumor-specific expression of insulin-like growth factor-I receptor, insulin receptor and phospho-insulin-like growth factor-I receptor/insulin receptor in primary breast cancer: Implications for prognosis in different treatment groups.

IGF1R INSR

4.47e-06274228030849
Pubmed

Targeting Insulin Receptor in Breast Cancer Using Small Engineered Protein Scaffolds.

IGF1R INSR

4.47e-06274228468775
Pubmed

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.

IGF1R INSR

4.47e-06274219835884
Pubmed

Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.

FLI1 ERG

4.47e-06274233275876
Pubmed

The expression and role of hybrid insulin/insulin-like growth factor receptor type 1 in endometrial carcinoma cells.

IGF1R INSR

4.47e-06274220620597
Pubmed

Insulin-like growth factor type 1 receptor and insulin receptor isoform expression and signaling in mammary epithelial cells.

IGF1R INSR

4.47e-06274219406949
Pubmed

Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis.

IGF1R INSR

4.47e-06274227905925
Pubmed

Regulation of upstream binding factor 1 activity by insulin-like growth factor I receptor signaling.

IGF1R UBTF

4.47e-06274215533945
Pubmed

Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations.

IGF1R INSR

4.47e-06274219524295
Pubmed

ERG and FLI1 are useful immunohistochemical markers in phosphaturic mesenchymal tumors.

FLI1 ERG

4.47e-06274226122367
Pubmed

Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier.

IGF1R INSR

4.47e-06274215063759
Pubmed

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation.

IGF1R INSR

4.47e-06274218650937
Pubmed

Genotype-Structure-Phenotype Correlations of Disease-Associated IGF1R Variants and Similarities to Those of INSR Variants.

IGF1R INSR

4.47e-06274234074726
Pubmed

A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding.

IGF1R INSR

4.47e-06274230213860
Pubmed

Epithelial-mesenchymal transition predicts sensitivity to the dual IGF-1R/IR inhibitor OSI-906 in hepatocellular carcinoma cell lines.

IGF1R INSR

4.47e-06274222161861
Pubmed

IGF-I and insulin activate mitogen-activated protein kinase via the type 1 IGF receptor in mouse embryonic stem cells.

IGF1R INSR

4.47e-06274217641087
Pubmed

Deficiency in insulin-like growth factors signalling in mouse Leydig cells increase conversion of testosterone to estradiol because of feminization.

IGF1R INSR

4.47e-06274232975906
Pubmed

Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity.

IGF1R INSR

4.47e-06274229040448
Pubmed

Engineered ubiquitin ligase PTB-U-box targets insulin/insulin-like growth factor receptor for degradation and coordinately inhibits cancer malignancy.

IGF1R INSR

4.47e-06274224970814
Pubmed

Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor.

IGF1R INSR

4.47e-06274228096258
Pubmed

Expression and purification of functional insulin and insulin-like growth factor 1 holoreceptors from mammalian cells.

IGF1R INSR

4.47e-06274228830678
Pubmed

Periovulatory insulin signaling is essential for ovulation, granulosa cell differentiation, and female fertility.

IGF1R INSR

1.34e-05374231908002
Pubmed

Insulin receptor-related receptor as an extracellular alkali sensor.

IGF1R INSR

1.34e-05374221641549
Pubmed

MAP3K4 promotes fetal and placental growth by controlling the receptor tyrosine kinases IGF1R/IR and Akt signaling pathway.

IGF1R INSR

1.34e-05374235921893
Pubmed

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.

MET NOS2

1.34e-05374229045907
Pubmed

MicroRNA 322 Aggravates Dexamethasone-Induced Muscle Atrophy by Targeting IGF1R and INSR.

IGF1R INSR

1.34e-05374232046161
Pubmed

Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant.

IGF1R INSR

1.34e-05374216831875
Pubmed

Insulin-like growth factor 1 receptor (IGF1R) signaling regulates osterix expression and cartilage matrix mineralization during endochondral ossification.

IGF1R INSR

1.34e-05374226475121
Pubmed

Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.

IGF1R INSR

1.34e-05374225269484
Pubmed

FLI1 and ERG protein degradation is regulated via Cathepsin B lysosomal pathway in human dermal microvascular endothelial cells.

FLI1 ERG

1.34e-05374232979864
Pubmed

Insulin regulates neurovascular coupling through astrocytes.

IGF1R INSR

1.34e-05374235858325
CytobandEnsembl 112 genes in cytogenetic band chr1q21

PPIAL4C PPIAL4E PPIAL4H PPIAL4G ENSA PPIAL4F

5.00e-05404746chr1q21
Cytoband1q21.2

PPIAL4C PPIAL4E PPIAL4F

2.12e-04717431q21.2
GeneFamilyReceptor Tyrosine Kinases|CD molecules

MET IGF1R INSR

1.52e-0440473321
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZXDC ZNF596 ZNF335 PLAG1 PLAGL2 ZNF749 ZNF101 ZNF681

4.74e-0471847828
GeneFamilyETS transcription factor family

FLI1 ERG

2.39e-0328472534
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

CNOT10 TTC13 NAA16

3.32e-03115473769
ToppCellNS-critical-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

OR2L8 FADS1 ERG RAPGEF5 DNTT

7.06e-06160745c61869d9dbba250270e59366e15af204e5b4395d
ToppCellCOVID-19-kidney-Lymphatic_EC|kidney / Disease (COVID-19 only), tissue and cell type

FLI1 ERG SV2B ACKR3 LAMA4

8.69e-0616774597d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCellCOVID-19-Heart-Lymph_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ERG RAPGEF5 SV2B ACKR3 LAMA4

1.15e-05177745326fde0734ef0d7272693966d346ca479b9d8147
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZXDC FADS1 INSR PLAGL2 RFC3

1.28e-051817452b9b460239d67fd480cee60820cdb306109d3567
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZXDC FADS1 INSR PLAGL2 RFC3

1.28e-051817452a1aa4a0ec7bc367857beaff543135e4345c835b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLI1 ERG RAPGEF5 INSR NOS2

1.35e-05183745dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLI1 ERG RAPGEF5 INSR NOS2

1.35e-051837454759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLI1 ERG RCAN1 SV2B ACKR3

1.35e-05183745bc98df870de65aff6dab295c24cbc199c7f2aa15
ToppCell10x5'-GI_small-bowel-Myeloid_Monocytic-Nonclassical_monocytes|GI_small-bowel / Manually curated celltypes from each tissue

PTPRO INSR CSTA TMEM63C PLAGL2

1.46e-05186745a16ecf70271894a842925f232009e2623d16947e
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|368C / Donor, Lineage, Cell class and subclass (all cells)

ZNF512B MET SH2D4A PLAGL2 SOCS7

1.50e-05187745b827d9da7032bf051756ddf88352af922eb0f87b
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ZNF512B MET SH2D4A PLAGL2 SOCS7

1.50e-0518774561c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCellCOVID-19-kidney-VWF+PLVAP+VCAM1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLI1 ERG RAPGEF5 SV2B INSR

1.58e-05189745c121817ddad164e9cfe382c43d0cbc9215508d02
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERG RAPGEF5 SV2B ACKR3 LAMA4

1.62e-05190745876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCellhuman_hepatoblastoma-Endothelial_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

FLI1 ERG RAPGEF5 ACKR3 LAMA4

1.62e-051907458d6ef93d69e96cd6921816d152bea3b0710cf147
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERG RAPGEF5 SV2B ACKR3 LAMA4

1.62e-05190745be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERG RAPGEF5 SV2B ACKR3 LAMA4

1.62e-0519074509a8855901c3c9332dbaab3e40166485b696d0f1
ToppCellfacs-Heart-LA-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ERG ACKR3 NOS2 SPATA13

1.66e-05191745a15f0fb4bd7dd77ef5f931b6fc9d68697deec1d1
ToppCellfacs-Heart-LA-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 ERG ACKR3 NOS2 SPATA13

1.66e-05191745827be47d3574c6c5b021c6f1c1670834344f10cb
ToppCellhuman_hepatoblastoma-Endothelial_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

FLI1 ERG RAPGEF5 ACKR3 LAMA4

1.70e-05192745e09f609fed033a25baacaf4a07bbbae1076da366
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLI1 ERG RAPGEF5 SV2B INSR

1.75e-051937451f978e102a029a6beb10913052cd0a20c7253e8e
ToppCellControl_saline-Endothelial-Endothelial-Activated_Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

FLI1 SAMD9 RAPGEF5 PINX1 SOCS7

1.98e-051987453c3a5d2555f6af4aa33f9ea778808315d0e39d86
ToppCellBiopsy_IPF-Endothelial-Lymphatic_Endothelial_cells|Biopsy_IPF / Sample group, Lineage and Cell type

ERG RAPGEF5 SV2B ACKR3 LAMA4

2.02e-05199745483b01f1308eb201a1ff3788fe656c486b6b9e66
ToppCellASK452-Endothelial|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

FLI1 ERG RCAN1 RAPGEF5 LAMA4

2.02e-051997450bc97a9a78aaafd1554ae6a61356ed9ea4983fa5
ToppCellNeuronal-Excitatory-eC(RORB)|Neuronal / cells hierarchy compared to all cells using T-Statistic

MET NWD2 SV2B LAMA4 MEGF10

2.07e-052007458c803a0ce25e140b46036f6aabefc5502601f408
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FLI1 ERG RAPGEF5 LAMA4 PINX1

2.07e-05200745dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_only-Endothelial-Endothelial-Activated_Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

FLI1 ERG RCAN1 RAPGEF5 PINX1

2.07e-052007456f531a418ff25b59a543800cf4bce7b72404ce08
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FLI1 ERG RCAN1 RAPGEF5 PINX1

2.07e-052007452d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

FLI1 ERG RAPGEF5 LAMA4 PINX1

2.07e-05200745eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MET IGF1R RFC3 SOCS7

1.43e-041597448680b054622f573a82b1625fb93c2d5db81d1034
ToppCellCOVID-19-kidney-Epithelial_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

FLI1 ERG RAPGEF5 SV2B

1.46e-041607440d4880f85565d8c540c94a8f8109147b3029279a
ToppCellNS-critical-LOC-Myeloid-Basophil|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

OR2L8 ERG RAPGEF5 DNTT

1.46e-041607448a4746463ca1976f7d6de803496c851249ced797
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKM URB1 SOCS7 DNTT

1.50e-04161744ed93cb6c133855a5c244821e1a260aae8ab4df9a
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKM URB1 SOCS7 DNTT

1.50e-041617440089d7bb305c592392791862a3341fc92af8f3e2
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLI1 ERG RCAN1 RAPGEF5

1.68e-04166744f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BLM FADS1 FHDC1 RFC3

1.72e-04167744108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-B_cells-Pro-B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLI1 MIS18BP1 ERG DNTT

1.76e-04168744c833e3311af2582787d3ff2ad59d802fff865f8f
ToppCellEndothelial-B-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

ERG SV2B LAMA4 PPIAL4A

1.76e-041687444977c3837fbb1f36c89fddd5764e37290ac25ad8
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-Pro-B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLI1 MIS18BP1 ERG DNTT

1.93e-04172744001d2553a0b5dae3269727bda8ef8067deebab0d
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Follicular-7|TCGA-Thryoid / Sample_Type by Project: Shred V9

GBA3 NWD2 CLPB OSBPL6

2.10e-041767449a4cef3dc88f64a71b91ab4790ea19334afee3ee
ToppCelltumor_Lung-Endothelial_cells-EPCs|tumor_Lung / Location, Cell class and cell subclass

ERG RAPGEF5 INSR AK7

2.15e-04177744f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERG RAPGEF5 SV2B LAMA4

2.20e-04178744ad3de3e03a401dac64431a541899445262246347
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MET NWD2 SV2B LAMA4

2.20e-04178744731e1e8eff2c4018c75dfc66632a316010a09a9a
ToppCellBAL-Mild-cDC_4|Mild / Compartment, Disease Groups and Clusters

ZNF512B RCAN1 UBTF NAA16

2.24e-0417974468511e87b12b8253de7771e5ccfc5869248b8450
ToppCellEndothelial|World / shred by cell class for turbinate

FLI1 MAPRE3 ERG LAMA4

2.24e-04179744052b2681974be00efb8503fa4e2c85d91d5ebd06
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLI1 ERG RAPGEF5 INSR

2.24e-041797441ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLI1 MET ERG RAPGEF5

2.24e-041797442a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLI1 ERG RAPGEF5 NOS2

2.29e-04180744d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MET NWD2 SV2B LAMA4

2.34e-041817446e8c5460021d3999daec58e3d6661a6fa998fd16
ToppCell5'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERG RAPGEF5 ACKR3 LAMA4

2.34e-041817447d7d1edeae4e0ebe40b324d1231cd26e27ba9d42
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERG RAPGEF5 SV2B LAMA4

2.34e-04181744e898ecb8d8f2eb2204225b7b0d665cadcd241139
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAPGEF5 LAMA4 FHDC1 PPIC

2.34e-04181744a53f05c4c47465ee62e353716456bd09ab464b23
ToppCelltumor_Lymph_Node_/_Brain-Endothelial_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

ERG SV2B INSR LAMA4

2.39e-04182744d7cce5dd7046f06bf40f00c9dbfa610722b03333
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERG RAPGEF5 SV2B LAMA4

2.39e-0418274441b070085edba7a58b81c20aa4942d06f745acf8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERG RAPGEF5 SV2B LAMA4

2.39e-041827445e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERG RAPGEF5 SV2B LAMA4

2.39e-04182744b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ERG OSBPL6 FHDC1 AK7

2.44e-041837446f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERG RAPGEF5 SV2B LAMA4

2.44e-041837444d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERG RAPGEF5 ACKR3 OSBPL6

2.44e-041837442d0d3b486498a7903fa9a1f48b189291da49c430
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MET NWD2 SV2B LAMA4

2.44e-04183744274076a0978bce2bd53a1732045f18ef0f2d9985
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLI1 ERG RAPGEF5 SV2B

2.44e-04183744ff95382cfed592190d0636d2b750328471f82e0d
ToppCell3'-Broncho-tracheal-Endothelial-Lymphatic_EC|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERG RCAN1 SV2B LAMA4

2.49e-0418474415cbddea9efb2346a2028d77edfe9ba32923568f
ToppCell3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERG RCAN1 SV2B LAMA4

2.49e-041847440087c605c161fd8a39aa394f51994a04e8353bf1
ToppCell3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERG RCAN1 SV2B LAMA4

2.49e-04184744968afa6b5ba84169377a24c150bb68749fa674d9
ToppCell3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERG RCAN1 SV2B LAMA4

2.49e-04184744920f95625978132c2b6c76654ef6298244103e2d
ToppCellLPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLI1 ERG RCAN1 ACKR3

2.54e-04185744808d5e880069aff8866cd2c733b9fe568a37701f
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

ERG RAPGEF5 SV2B LAMA4

2.54e-041857444a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCellControl-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

ERG ACKR3 INSR SOCS7

2.54e-041857446814b3c94c7558443c038a227b5c8563d2cfeac4
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

ERG RAPGEF5 SV2B LAMA4

2.54e-0418574436ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPIAL4A FHDC1 CERT1 MEGF10

2.54e-04185744dd17025d8c423aa0a451ac7f1f301c93528e0229
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERG RAPGEF5 SV2B LAMA4

2.60e-0418674440070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF512B ZNF335 TBCK SOCS7

2.60e-0418674477bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|356C / Donor, Lineage, Cell class and subclass (all cells)

ERG RAPGEF5 LAMA4 NOS2

2.60e-04186744f0b78c7ee20279970ea8961bf59acb5262f2dce5
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERG RAPGEF5 SV2B LAMA4

2.60e-0418674420340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF512B ZNF335 TBCK SOCS7

2.60e-0418674413bc41c60fd628af31899a5e8b480e06cc4781be
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|356C / Donor, Lineage, Cell class and subclass (all cells)

ERG RAPGEF5 LAMA4 NOS2

2.60e-041867442b3c814a7dee8286ea113c63dc3de5daf0257d37
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

MET IGF1R INSR SOCS7

2.65e-04187744ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

FLI1 MET ERG RAPGEF5

2.65e-0418774440ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERG RAPGEF5 SV2B LAMA4

2.65e-0418774465d406122dffe18279f14a1ed35ba091730b97be
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERG RAPGEF5 SV2B LAMA4

2.65e-041877444c15c0ed41a55271fc793cb76fee97fa64190369
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERG RAPGEF5 SV2B LAMA4

2.65e-041877445274f2b302bbf7fed30c480af4f35058d2cf61e0
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D175|Adult / Lineage, Cell type, age group and donor

ERG RAPGEF5 SV2B LAMA4

2.65e-041877441e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma|TCGA-Kidney / Sample_Type by Project: Shred V9

FLI1 ACKR3 INSR LAMA4

2.70e-04188744e711c7a46d7cfa030ca2982eacc1dae5af5788dd
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MET NWD2 RAPGEF5 SV2B

2.70e-0418874450c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCelldroplet-Lung-1m-Epithelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SH2D4A OSBPL6 FHDC1 AK7

2.76e-0418974472ecd5a10e419bac475e22f5b602e7f008835ce9
ToppCellCOVID-19-lung-Lymphatic_EC|lung / Disease (COVID-19 only), tissue and cell type

ERG SV2B ACKR3 LAMA4

2.76e-04189744c8db9aaf54ea3cc96c4a2f777c3389e0f31f67f3
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

OR1N1 FLI1 ERG RAPGEF5

2.76e-041897447346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCellCOVID-19-Heart-EC_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLI1 ERG RAPGEF5 SV2B

2.76e-04189744fe49852ba15f948b384d6b4c258927c70b741357
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERG RCAN1 SV2B ACKR3

2.76e-0418974455a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

MET IGF1R INSR SOCS7

2.81e-04190744756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BLM ERG RAPGEF5 SV2B

2.81e-0419074431de1727822e9818652946dfb962daee77ffad68
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

BLM ERG FHDC1 RFC3

2.81e-04190744e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCell5'-Adult-LymphNode-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERG RAPGEF5 ACKR3 LAMA4

2.81e-041907446b704deeb44e1ffa10e604d0e5612b022f6cd9a6
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ERG RAPGEF5 SV2B INSR

2.87e-041917442f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCellCOVID-19-lung-Lymphatic_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ERG SV2B ACKR3 LAMA4

2.93e-04192744cbe57cda44232b183821ac633b60a2668265e616
ToppCellFibroblasts-CD55+_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

MET SV2B ACKR3 PPIC

2.99e-041937448f4bf9a2fbedae35432dad96730b00c70185874c
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLI1 ERG RAPGEF5 SPATA13

2.99e-04193744f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 IGF1R ERG CERT1

2.99e-04193744e4b440d50ae7391b26924778be6d9d53e0692449
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 IGF1R ERG CERT1

2.99e-04193744e523dc5751f6fdcd4fc1a62b1eecd43f6ae79da9
ToppCellPCW_10-12-Endothelial-Endothelial_cycling-endo_proliferating1_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FLI1 ERG RAPGEF5 ACKR3

2.99e-04193744643f992dbce639e7d147924d8b8f455fcebf215a
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLI1 IGF1R ERG CERT1

2.99e-041937441772f2ac217727de63c4a9303881b3a19a6bb0f0
DrugPantothenic acid calcium salt monohydrate [63409-48-3]; Down 200; 8uM; HL60; HT_HG-U133A

FLI1 SAMD9 RCAN1 XPO6 INSR PLAGL2 RFC3

2.47e-061977071311_DN
DrugInsulin Glargine

IGF1R INSR

9.32e-062702ctd:D000069036
DrugInsulin Lispro

IGF1R INSR

9.32e-062702DB00046
DrugInsulin Glargine

IGF1R INSR

9.32e-062702DB00047
Druggeldanamycin

ZXDC TPP2 MET MIS18BP1 RCAN1 LAMA4 RFX7 NOS2

1.80e-05371708ctd:C001277
Diseasegastroschisis (biomarker_via_orthology)

IGF1R NOS2

1.39e-053642DOID:11044 (biomarker_via_orthology)
Diseasegastrinoma (is_marker_for)

MET IGF1R

1.39e-053642DOID:5577 (is_marker_for)
DiseaseExtra-osseous Ewing's sarcoma

FLI1 ERG

2.77e-054642C0279980
Diseasegestational diabetes (biomarker_via_orthology)

IGF1R INSR

4.61e-055642DOID:11714 (biomarker_via_orthology)
Diseaseneutropenia, response to metamizole, Drug-induced agranulocytosis

PTPRO RFC3

6.91e-056642EFO_0010971, HP_0012235, MONDO_0001475
DiseaseDevelopmental delay (disorder)

IGF1R UBTF ZNF335

7.17e-0537643C0424605
DiseaseLewy body dementia (is_implicated_in)

IGF1R NOS2

9.66e-057642DOID:12217 (is_implicated_in)
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

FADS1 ZNF335 INSR PINX1 CERT1

1.28e-04224645EFO_0004530, EFO_0008317
DiseaseIntestinal Diseases

SAMD9 NOS2

1.29e-048642C0021831
DiseaseEwings sarcoma

FLI1 ERG

1.29e-048642C0553580
Diseasealcohol dependence (implicated_via_orthology)

IGF1R INSR

1.65e-049642DOID:0050741 (implicated_via_orthology)
Diseasesleep disorder (implicated_via_orthology)

IGF1R INSR

2.52e-0411642DOID:535 (implicated_via_orthology)
Diseaselevel of Sterol ester (27:1/20:5) in blood serum

NWD2 FADS1

2.52e-0411642OBA_2045197
Diseasedementia (is_implicated_in)

IGF1R NOS2

3.01e-0412642DOID:1307 (is_implicated_in)
Diseasediabetic neuropathy (implicated_via_orthology)

IGF1R INSR

4.14e-0414642DOID:9743 (implicated_via_orthology)
Diseasehepatic encephalopathy (biomarker_via_orthology)

INSR NOS2

4.77e-0415642DOID:13413 (biomarker_via_orthology)
Diseasealbumin:globulin ratio measurement

FLI1 FADS1 ENSA

5.43e-0473643EFO_0005128
Diseasepulmonary function measurement

ACKR3 TBCK SPATA13

6.35e-0477643EFO_0003892
DiseaseCongenital hernia of foramen of Morgagni

IGF1R INSR

7.73e-0419642C0265699
DiseaseCongenital hernia of foramen of Bochdalek

IGF1R INSR

7.73e-0419642C0265700
Diseaseprostate adenocarcinoma (is_implicated_in)

IGF1R INSR

8.58e-0420642DOID:2526 (is_implicated_in)
DiseaseFetal Growth Retardation

IGF1R SAMD9

8.58e-0420642C0015934
DiseaseKidney Diseases

SV2B ACKR3 NOS2

9.36e-0488643C0022658
DiseaseCongenital diaphragmatic hernia

IGF1R INSR

9.47e-0421642C0235833
DiseaseLewy Body Disease

IGF1R INSR

1.04e-0322642C0752347
DiseaseNeoplasm Metastasis

MET CTU2 ACKR3 CSTA

1.28e-03217644C0027627
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

FADS1 INSR PINX1 CERT1

1.35e-03220644EFO_0004529, EFO_0008317
Diseasediabetes mellitus (implicated_via_orthology)

IGF1R INSR

1.46e-0326642DOID:9351 (implicated_via_orthology)
Diseasealkaline phosphatase measurement

ZNF512B FLI1 NWD2 FADS1 SAMD9 XPO6 PINX1 ZNF101

1.53e-031015648EFO_0004533
Diseaseglucose metabolism disease (implicated_via_orthology)

IGF1R INSR

1.69e-0328642DOID:4194 (implicated_via_orthology)
Diseasehepatocellular carcinoma (biomarker_via_orthology)

MET INSR NOS2

1.69e-03108643DOID:684 (biomarker_via_orthology)
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

FADS1 ZNF335 INSR CERT1

1.82e-03239644EFO_0008317, EFO_0020945
DiseaseDrug habituation

GBA3 XPO6 INSR

2.02e-03115643C0013170
DiseaseDrug abuse

GBA3 XPO6 INSR

2.02e-03115643C0013146
DiseasePrescription Drug Abuse

GBA3 XPO6 INSR

2.02e-03115643C4316881
DiseaseSubstance-Related Disorders

GBA3 XPO6 INSR

2.02e-03115643C0236969
DiseaseDrug Use Disorders

GBA3 XPO6 INSR

2.02e-03115643C0013222
DiseaseDrug Dependence

GBA3 XPO6 INSR

2.02e-03115643C1510472
DiseaseSubstance Dependence

GBA3 XPO6 INSR

2.02e-03115643C0038580
DiseaseSubstance Use Disorders

GBA3 XPO6 INSR

2.02e-03115643C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

GBA3 XPO6 INSR

2.02e-03115643C0029231
Diseaseuric acid measurement

GBA3 IGF1R UBTF INSR ENSA AK7

2.07e-03610646EFO_0004761
DiseaseSubstance abuse problem

GBA3 XPO6 INSR

2.07e-03116643C0740858

Protein segments in the cluster

PeptideGeneStartEntry
SDFLMKRLQKGQKYF

ENSA

51

O43768
EKEALKGKSFHMFIY

EDDM3A

56

Q14507
NIMTKVHGKRYAYKF

ERG

376

P11308
SHRMKAVDFYSGKVK

AASDH

791

Q4L235
FKLAQTYMDKLSKHG

APPBP2

186

Q92624
KGKMKHSQAKRYLFS

NWD2

221

Q9ULI1
LHKTEFLGKEMKLYF

RCAN1

126

P53805
ESSMKNSFGLKYLHK

RABL6

211

Q3YEC7
YKNAMTELKKKSHFG

CERT1

291

Q9Y5P4
FIIYRHKQKGKESSM

MEGF10

876

Q96KG7
KFLFKTKFHQYAMNG

NOS2

6

P35228
NGYSHLGKKKRMRSF

FHDC1

86

Q9C0D6
AMEHFGYRNSKTSKK

PPIAL4C

141

A0A0B4J2A2
KYVFRMQKYHKSNGG

MIS18BP1

1056

Q6P0N0
FLNKMRIYDGKKHFI

MAGEB3

226

O15480
HAMRGRLFYTAKAKK

TMEM63C

271

Q9P1W3
HRNLTIKAGKMYFAF

IGF1R

436

P08069
LFAVYHMKSAEGRKK

OR2L8

221

Q8NGY9
FYMKAKIYKHIGNLK

NAA16

411

Q6N069
KNRVHYMKFTKGKDL

PINX1

121

Q96BK5
GMAYLNAKKFVHRDL

INSR

1146

P06213
AMEHFGYRNSKTSKK

PPIAL4F

141

P0DN26
EKMLANFESGKHKYR

DDX23

586

Q9BUQ8
KRFFVLDNGMLKYSK

OSBPL6

106

Q9BZF3
AMEHFGYRNSKTSKK

PPIAL4E

141

A0A075B759
MLYKDFFKGKTVFNH

PTPRO

166

Q16827
TLYKLGFFKRHYKEM

ITGAD

1121

Q13349
AMEHFGYRNSKTSKK

PPIAL4H

141

A0A075B767
AMEHFGYRNSKTSKK

PPIAL4A

141

Q9Y536
AMEHFGYRNSKTSKK

PPIAL4G

141

P0DN37
MKIFHKKFGLHNFRT

BLM

656

P54132
HSYDSLFRKKQKGMV

GBA3

206

Q9H227
NIMTKVHGKRYAYKF

FLI1

346

Q01543
LMKAFIFKYSAKTGL

ACKR3

326

P25106
KVRAGDNKYMHLKVF

CSTA

56

P01040
FVAFHINKGLVKKYM

FADS1

71

O60427
YIHNFKVLQAAFKKM

MAPRE3

71

Q9UPY8
FARFVAMKYIKSNSK

HAUS6

131

Q7Z4H7
KYMHKDAKKGFIRLD

CLPB

396

Q9H078
KNFRIYSLDMKKSFF

GLB1L2

516

Q8IW92
LLKGKMKVSYRGHFL

BVES

176

Q8NE79
FKAFYVHKFRAMLGK

CTU2

51

Q2VPK5
HLEAFVAKFMALYKK

RFC3

331

P40938
YMFNVGHKKLKIRSQ

LAMA4

1531

Q16363
FIYSLRNKDMKGALK

OR1N1

286

Q8NGS0
LFAVYHMHSKEGRKK

OR2L13

221

Q8N349
GMKYLASKKFVHRDL

MET

1191

P08581
GYKGSKFHRVIKDFM

PPIC

81

P45877
HGKLVNDKFTRMYFK

SV2B

451

Q7L1I2
GFKRFKYSKFSHMHL

BMT2

301

Q1RMZ1
KSLKFTRMQKAGFLY

DNTT

281

P04053
MPFGNTHNKFKLNYK

CKM

1

P06732
KNSFKGQYKHMHRTK

SAMD9

1461

Q5K651
SLNHKAYRDAFKKMK

RAPGEF5

476

Q92565
KGLKFRYQDHTFLKM

URB1

1436

O60287
GKAFASKYKLYRHMA

PLAGL2

76

Q9UPG8
GSFNYLKFFKHIRKL

PVALEF

36

A0A1B0GWK0
MSKHNLGIFYFKKAL

CNOT10

306

Q9H9A5
KAFVSKYKLQRHMAT

PLAG1

71

Q6DJT9
ANLMKQGKYRHFFEA

SPATA13

346

Q96N96
MLYKGLTFFHRGLLK

TTC13

286

Q8NBP0
ITYMRTKHFVSKKFG

ZNF596

131

Q8TC21
GKKFTTVYNLKAHMK

ZXDC

246

Q2QGD7
CGKFFMYNSKLIRHQ

ZNF749

331

O43361
YKHALVNKMYGRGLK

TPP2

1186

P29144
DSINRMKAYAFHQKK

SH2D4A

186

Q9H788
KYCYSGLRKKAFVHM

RFX7

76

Q2KHR2
RKGHIKLAKFGLYHM

TBCK

126

Q8TEA7
KRAIMHSKNGKFLYF

SOCS7

476

O14512
RKQFKSKAGLNYHTM

ZNF512B

546

Q96KM6
FFRKHGKMHTGEKRY

ZNF101

211

Q8IZC7
KYMKIFHKFSNLNGH

ZNF681

146

Q96N22
KLYHKKIFRTAMLFQ

XPO6

1011

Q96QU8
RFFMEKRAKYAKLHP

UBTF

121

P17480
GKSFKKRYTFKMHLL

ZNF335

596

Q9H4Z2
MVLKFGKKARKFAAY

AK7

196

Q96M32