Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription elongation factor activity

EAF1 TCERG1

5.39e-059252GO:0003711
GeneOntologyMolecularFunctiontranscription factor binding

LATS1 EAF1 SRA1 ARID1A TCERG1 NFATC4

2.70e-04753256GO:0008134
GeneOntologyMolecularFunctiontelomerase RNA binding

WRAP53 SNRPB

4.44e-0425252GO:0070034
GeneOntologyMolecularFunctionnuclear receptor binding

LATS1 SRA1 ARID1A

1.60e-03187253GO:0016922
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

LATS1 SRA1 ARID1A TCERG1

1.67e-03417254GO:0061629
GeneOntologyCellularComponentnuclear speck

RBM15B ESX1 ATXN2L EAF1 TCERG1 NFATC4

9.42e-06431256GO:0016607
GeneOntologyCellularComponentnuclear body

RBM15B ESX1 ATXN2L EAF1 WRAP53 TCERG1 NFATC4

6.65e-05903257GO:0016604
GeneOntologyCellularComponenttelomerase holoenzyme complex

WRAP53 SNRPB

4.05e-0425252GO:0005697
Pubmed

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

ATXN2L SNRPB HNRNPK

1.32e-063025315782174
Pubmed

Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.

LATS1 ARID1A TCERG1

9.36e-065725338223760
Pubmed

WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies.

WRAP53 SNRPB

1.04e-05725221072240
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

RBM15B ATXN2L RIMS1 LATS1 WRAP53 HNRNPK

1.47e-0577425615302935
Pubmed

The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1.

TCERG1 SNRPB

3.26e-051225211604498
Pubmed

The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.

TCERG1 SNRPB

3.85e-051325217218272
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

ATXN2L LATS1 ARID1A TCERG1 HNRNPK

3.94e-0554925538280479
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

RBM15B ATXN2L ARID1A TCERG1 SNRPB HNRNPK

4.75e-0595425636373674
Pubmed

Comprehensive proteomic analysis of the human spliceosome.

TCERG1 SNRPB HNRNPK

6.55e-0510925312226669
Pubmed

Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.

TCERG1 SNRPB HNRNPK

7.68e-0511525317332742
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

RBM15B ARID1A MAP1A TCERG1 SNRPB HNRNPK

9.53e-05108225638697112
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

RBM15B ATXN2L MIA2 DPY19L1 HNRNPK GRAMD1A

1.70e-04120325629180619
Pubmed

Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

RBM15B ATXN2L HNRNPK

1.75e-0415225316009940
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

ARID1A TCERG1 HNRNPK

1.82e-0415425316055720
Pubmed

RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.

ATXN2L ARID1A

1.99e-042925236800290
Pubmed

Aerobic glycolysis tunes YAP/TAZ transcriptional activity.

LATS1 ARID1A SNRPB

2.12e-0416225325796446
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

LATS1 MIA2 MAP1A NFATC4

2.37e-0443025435044719
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

RBM15B ATXN2L TCERG1 SNRPB HNRNPK

2.40e-0480725522681889
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

ATXN2L TCERG1 SNRPB HNRNPK

2.61e-0444125431239290
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

ATXN2L ARID1A TCERG1 SNRPB HNRNPK

3.00e-0484725535235311
Pubmed

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.

EPHB3 SNRPB

3.25e-043725226951610
Pubmed

A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex.

ARID1A HNRNPK

3.43e-043825232541003
Pubmed

Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.

TCERG1 HNRNPK

3.43e-043825228218735
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

ATXN2L TCERG1 CARMIL3 HNRNPK

3.46e-0447525431040226
Pubmed

A human MAP kinase interactome.

LATS1 MAP1A TCERG1 HNRNPK

3.77e-0448625420936779
Pubmed

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.

EPHB3 NFATC4

4.20e-044225211439183
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MMP21 RIMS1 LATS1 MIA2 ARID1A SNRPB

4.51e-04144225635575683
Pubmed

SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication.

ATXN2L SNRPB HNRNPK

4.91e-0421625337640791
Pubmed

Identification of DeltaNp63alpha protein interactions by mass spectrometry.

MAP1A HNRNPK

5.48e-044825220085233
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

RIMS1 MAP1A HNRNPK

5.97e-0423125316452087
Cytoband14q11.2

NFATC4 CARMIL3

4.32e-0318025214q11.2
Diseasecolorectal cancer (is_marker_for)

WRAP53 ARID1A HNRNPK

2.76e-04157243DOID:9256 (is_marker_for)
Diseasenasopharynx carcinoma (is_marker_for)

WRAP53 ARID1A

5.61e-0443242DOID:9261 (is_marker_for)
Diseaselung adenocarcinoma (is_marker_for)

WRAP53 SNRPB

2.17e-0385242DOID:3910 (is_marker_for)
Diseasecomplement factor D measurement

EPHB3 GRAMD1A

2.59e-0393242EFO_0020283
Diseaselipoprotein measurement

ARID1A NFATC4

3.29e-03105242EFO_0004732
Diseaseverbal-numerical reasoning measurement

ATXN2L NOTO

5.06e-03131242EFO_0008394
Diseaselung non-small cell carcinoma (is_implicated_in)

WRAP53 ARID1A

5.68e-03139242DOID:3908 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
VPPGSRMAPVPPGPR

ESX1

276

Q8N693
PPMPFRAPTKPPVGP

EAF1

141

Q96JC9
LPPSRPPPEPEPGTM

GRAMD1A

26

Q96CP6
PPPPAVGRMYPPRSP

ATXN2L

436

Q8WWM7
SGMSPRASPLPPPPP

RBM15B

106

Q8NDT2
GPSAPVPPMTRPPPS

ARID1A

1556

O14497
PTVPPRPEPGPSMEP

MAP1A

2041

P78559
PRGQTPPPRGTTPPP

LATS1

251

O95835
PPRTTPPGPGRPSMP

CARMIL3

981

Q8ND23
DMRPPPPSAPPSPPG

MMP21

121

Q8N119
MPSPRPRGSPPPAPS

NOTO

1

A8MTQ0
MEGRPPPEGRPPPRP

DPY19L1

1

Q2PZI1
MARARPPPPPSPPPG

EPHB3

1

P54753
RRPSGPGPPSPTPPA

DRD4

236

P21917
GPRGPRPPTVPPPMQ

RIMS1

6

Q86UR5
PPMRGPETTPPQPPT

EFCAB6

701

Q5THR3
GMPRPPPPSTRPLPP

COL27A1

431

Q8IZC6
LRRGPPFPPPPPGAM

MIA2

1321

Q96PC5
PRPRGSAPGPMETPP

GPR137B

6

O60478
MPPPPERGDPPRLSP

WRAP53

41

Q9BUR4
IPRPPPPRPGMHSPP

NFATC4

61

Q14934
PPRPGMHSPPPRPAP

NFATC4

66

Q14934
DDMSPRRGPPPPPPG

HNRNPK

281

P61978
PPPGMRPPPPGMRGP

SNRPB

216

P14678
RPPPPGMRGPPPPGM

SNRPB

221

P14678
RGPPPLMRPPPPFGM

TCERG1

41

O14776
PPMGPPPPSSKAPRS

SRA1

61

Q9HD15