Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	UBR2 UBR1 RNF168 RFPL1 RBBP6 RFPL3	4.13e-05	372	35	6	GO:0061630
GeneOntologyMolecularFunction	histone H2A ubiquitin ligase activity	UBR2 RNF168	4.46e-05	6	35	2	GO:0141053
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	UBR2 UBR1 RNF168 RFPL1 RBBP6 RFPL3	6.01e-05	398	35	6	GO:0061659
GeneOntologyMolecularFunction	L-leucine binding	UBR2 UBR1	6.23e-05	7	35	2	GO:0070728
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	UBR2 UBR1 RNF168 RFPL1 RBBP6 RFPL3	1.55e-04	473	35	6	GO:0004842
GeneOntologyMolecularFunction	histone ubiquitin ligase activity	UBR2 RNF168	1.95e-04	12	35	2	GO:0140852
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	UBR2 UBR1 RNF168 RFPL1 RBBP6 RFPL3	2.38e-04	512	35	6	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	UBR2 UBR1 RNF168 RFPL1 RBBP6 RFPL3	2.92e-04	532	35	6	GO:0016755
GeneOntologyMolecularFunction	acyltransferase activity	UBR2 UBR1 RNF168 RFPL1 RBBP6 RFPL3	2.08e-03	775	35	6	GO:0016746
GeneOntologyMolecularFunction	protein kinase binding	CDK5RAP1 SPRED1 MAP3K13 RFPL1 RBBP6 RFPL3	3.76e-03	873	35	6	GO:0019901
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process via the N-end rule pathway	UBR2 UBR1	1.67e-05	4	35	2	GO:0071596
Domain	ClpS_core	UBR2 UBR1	3.41e-06	2	35	2	IPR003769
Domain	ClpS	UBR2 UBR1	3.41e-06	2	35	2	PF02617
Domain	-	UBR2 UBR1	1.02e-05	3	35	2	3.30.1390.10
Domain	Ribosomal_L7/12_C/ClpS-like	UBR2 UBR1	1.02e-05	3	35	2	IPR014719
Domain	ZF_RING_1	UBR2 UBR1 RNF168 RFPL1 RBBP6 RFPL3	1.51e-05	291	35	6	PS00518
Domain	ZF_RING_2	UBR2 UBR1 RNF168 RFPL1 RBBP6 RFPL3	1.72e-05	298	35	6	PS50089
Domain	Znf_RING	UBR2 UBR1 RNF168 RFPL1 RBBP6 RFPL3	2.86e-05	326	35	6	IPR001841
Domain	RDM	RFPL1 RFPL3	3.40e-05	5	35	2	PF11002
Domain	RDM_domain_RFPL	RFPL1 RFPL3	3.40e-05	5	35	2	IPR022723
Domain	zf-UBR	UBR2 UBR1	7.12e-05	7	35	2	PF02207
Domain	Znf_UBR	UBR2 UBR1	7.12e-05	7	35	2	IPR003126
Domain	ZnF_UBR1	UBR2 UBR1	7.12e-05	7	35	2	SM00396
Domain	ZF_UBR	UBR2 UBR1	7.12e-05	7	35	2	PS51157
Domain	-	UBR2 UBR1 RNF168 RFPL1 RBBP6 RFPL3	1.68e-04	449	35	6	3.30.40.10
Domain	Znf_RING/FYVE/PHD	UBR2 UBR1 RNF168 RFPL1 RBBP6 RFPL3	1.89e-04	459	35	6	IPR013083
Domain	RING	UBR2 RNF168 RFPL1 RBBP6 RFPL3	2.44e-04	305	35	5	SM00184
Domain	WH1	SPRED1 PPP4R3A	2.63e-04	13	35	2	PS50229
Domain	PRY	RFPL1 RFPL3	2.80e-03	42	35	2	PF13765
Domain	PRY	RFPL1 RFPL3	3.65e-03	48	35	2	SM00589
Domain	PRY	RFPL1 RFPL3	3.65e-03	48	35	2	IPR006574
Domain	Butyrophylin	RFPL1 RFPL3	7.61e-03	70	35	2	IPR003879
Domain	ConA-like_dom	RFPL1 RFPL3 CRB2	7.90e-03	219	35	3	IPR013320
Domain	zf-C3HC4	RNF168 RFPL1 RFPL3	8.30e-03	223	35	3	PF00097
Domain	SPRY	RFPL1 RFPL3	1.16e-02	87	35	2	SM00449
Pathway	REACTOME_IRF3_MEDIATED_INDUCTION_OF_TYPE_I_IFN	NLRP4 TBK1	3.01e-05	5	25	2	MM14942
Pathway	REACTOME_IRF3_MEDIATED_ACTIVATION_OF_TYPE_1_IFN	NLRP4 TBK1	3.01e-05	5	25	2	M26979
Pathway	REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES	NLRP4 TBK1	6.31e-05	7	25	2	MM14706
Pathway	REACTOME_REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA	NLRP4 TBK1	2.33e-04	13	25	2	MM14931
Pathway	REACTOME_IRF3_MEDIATED_INDUCTION_OF_TYPE_I_IFN	NLRP4 TBK1	2.33e-04	13	25	2	M27240
Pathway	REACTOME_REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA	NLRP4 TBK1	3.13e-04	15	25	2	M27229
Pathway	REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES	NLRP4 TBK1	3.57e-04	16	25	2	M27045
Pathway	REACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS	NLRP4 TBK1	6.21e-04	21	25	2	M26978
Pathway	REACTOME_CYTOSOLIC_SENSORS_OF_PATHOGEN_ASSOCIATED_DNA	NLRP4 TBK1	1.45e-03	32	25	2	MM14707
Pubmed	Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase.	UBR2 UBR1	1.04e-06	2	36	2	28392261
Pubmed	Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway.	UBR2 UBR1	1.04e-06	2	36	2	20298436
Pubmed	Structural basis of substrate recognition and specificity in the N-end rule pathway.	UBR2 UBR1	1.04e-06	2	36	2	20835242
Pubmed	Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.	UBR2 UBR1	1.04e-06	2	36	2	16606826
Pubmed	Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).	UBR2 UBR1	1.04e-06	2	36	2	16311597
Pubmed	Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia.	UBR2 UBR1	1.04e-06	2	36	2	15548684
Pubmed	Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle.	UBR2 UBR1	3.12e-06	3	36	2	37057345
Pubmed	Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort.	GRN TBK1	3.12e-06	3	36	2	26674655
Pubmed	RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.	UBR2 UBR1	3.12e-06	3	36	2	15317757
Pubmed	Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development.	RFPL1 RFPL3	3.12e-06	3	36	2	18656177
Pubmed	Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway.	UBR2 UBR1	6.24e-06	4	36	2	14585983
Pubmed	The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway.	UBR2 UBR1	6.24e-06	4	36	2	32692156
Pubmed	NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.	NLRP4 TBK1	6.24e-06	4	36	2	22388039
Pubmed	An essential role of N-terminal arginylation in cardiovascular development.	UBR2 UBR1	6.24e-06	4	36	2	12098698
Pubmed	USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome.	NLRP4 TBK1	6.24e-06	4	36	2	27692986
Pubmed	DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation.	NLRP4 TBK1	6.24e-06	4	36	2	26407194
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR2 UBR1	6.24e-06	4	36	2	16055722
Pubmed	Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.	UBR2 UBR1	6.24e-06	4	36	2	11689692
Pubmed	The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.	UBR2 UBR1	6.24e-06	4	36	2	22670058
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR2 UBR1	6.24e-06	4	36	2	19008229
Pubmed	Duplications on human chromosome 22 reveal a novel Ret Finger Protein-like gene family with sense and endogenous antisense transcripts.	RFPL1 RFPL3	1.04e-05	5	36	2	10508838
Pubmed	The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.	RFPL1 RFPL3	1.04e-05	5	36	2	11850190
Pubmed	Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway.	UBR2 UBR1	1.56e-05	6	36	2	10805755
Pubmed	Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling.	UBR2 UBR1	1.56e-05	6	36	2	32366662
Pubmed	Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.	UBR2 UBR1	2.18e-05	7	36	2	21816346
Pubmed	RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.	RFPL1 RFPL3	2.91e-05	8	36	2	12525704
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR2 UBR1	3.73e-05	9	36	2	17855541
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR2 UBR1	6.83e-05	12	36	2	17360488
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBR2 UBR1 RNF168	1.32e-04	95	36	3	29643511
Pubmed	Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors.	OGN TBK1	2.38e-04	22	36	2	33304758
Pubmed	CPEB2-eEF2 interaction impedes HIF-1α RNA translation.	SEMA4B CAPN15	2.83e-04	24	36	2	22157746
Pubmed	ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles.	RFPL1 RFPL3	4.75e-04	31	36	2	31657143
Pubmed	KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.	UBR2 UBR1	5.39e-04	33	36	2	25582440
Pubmed	Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.	GPC1 RBBP6	5.72e-04	34	36	2	25505242
Pubmed	Web-based, participant-driven studies yield novel genetic associations for common traits.	CDK5RAP1 MC1R	5.72e-04	34	36	2	20585627
Pubmed	NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression.	RFPL1 RFPL3	6.78e-04	37	36	2	15326356
Interaction	RFPL2 interactions	PASK RFPL3 ZNF507	7.22e-06	22	35	3	int:RFPL2
Interaction	WNT10A interactions	UBR2 UBR1 PASK	3.58e-05	37	35	3	int:WNT10A
Interaction	RFPL1 interactions	RFPL1 RFPL3	4.38e-05	6	35	2	int:RFPL1
Interaction	NLRP4 interactions	NLRP4 TBK1	8.15e-05	8	35	2	int:NLRP4
Interaction	MFAP5 interactions	PASK GRN ZNF507	1.00e-04	52	35	3	int:MFAP5
Interaction	RASL10B interactions	PASK ACAD10 ZNF507	1.25e-04	56	35	3	int:RASL10B
Cytoband	16q24.3	PIEZO1 MC1R	7.73e-04	52	36	2	16q24.3
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR2 UBR1	3.84e-05	7	25	2	785
Drug	Baclofen (R,S) [1134-47-0]; Down 200; 18.8uM; PC3; HT_HG-U133A	SLC2A10 PASK ZNF442 RBBP6 PIEZO1 CAPN15	5.12e-07	197	35	6	6313_DN
Disease	Frontotemporal Lobar Degeneration	GRN TBK1	3.03e-05	7	36	2	C0751072
Disease	non-alcoholic fatty liver disease (implicated_via_orthology)	UBR2 UBR1	8.88e-04	36	36	2	DOID:0080208 (implicated_via_orthology)
Disease	atherosclerosis (is_marker_for)	UBR1 GRN	9.38e-04	37	36	2	DOID:1936 (is_marker_for)
Disease	Metastatic melanoma	PASK MAP3K13	1.99e-03	54	36	2	C0278883
Disease	JT interval	LIG3 NAA35 PRLHR	3.41e-03	248	36	3	EFO_0007885
Disease	depressive symptom measurement, response to antidepressant	MAP3K13 PIEZO1	5.19e-03	88	36	2	EFO_0007006, GO_0036276

Protein segments in the cluster

Peptide	Gene	Start	Entry
MEVSCPDGYTCCRLQ	GRN	286	P28799
CELMGTSLYAPEVCN	ACAD10	741	Q6JQN1
HYMCDILPLLECACT	OR8B8	176	Q15620
EPCDTVGIAYLSGMC	ADAMTS19	446	Q8TE59
CIMDVIGCLEYDPAL	PPP4R3A	216	Q6IN85
SPMYCFICCLALSDL	MC1R	71	Q01726
SCDVMLEPGEYAVVC	CAPN15	881	O75808
TFCGTIEYCAPEVLM	PASK	1161	Q96RG2
ECHCPLGYAGVTCEM	CRB2	131	Q5IJ48
ICPQGYTCCTSEMEE	GPC1	61	P35052
SMACCIYVSELVGPR	SLC2A10	116	O95528
MPTCLLCVCLSGSVY	OGN	91	P20774
CEALCSPDTVLVYLM	NLRP4	771	Q96MN2
IEDLSCVSCMPYLLE	LRGUK	161	Q96M69
EPQGLMYCLRCTCSE	CHRDL2	51	Q6WN34
LCSGPCEMAEQRFCV	LIG3	81	P49916
MTDAVVIPCCGNSYC	RBBP6	266	Q7Z6E9
GVCTQAPCYCIIMEY	MAP3K13	221	O43283
FTCSLLIVGMCCVSP	FAM237A	16	A0A1B0GTK4
YLEKPMSLECGCAVC	RFPL1	46	O75677
DVLMCTACVPLTLAY	PRLHR	106	P49683
VPMANCSLYRSCGDC	SEMA4B	521	Q9NPR2
CIETIMACSPCEGLY	CMTM4	71	Q8IZR5
RGCDNMCSYCIVPFT	CDK5RAP1	256	Q96SZ6
TLPELIGIMDTCFCC	NAA35	101	Q5VZE5
ALVALSFIVPCMCCY	SPRED1	406	Q7Z699
TSAQPFLCCLCGMIF	ZNF646	876	O15015
AIDPTCVLCMDCFQD	UBR1	116	Q8IWV7
YLEKPMSLECGCTVC	RFPL3	46	O75679
DAIPSLSECQCGICM	RNF168	6	Q8IYW5
CGEIMGCSFLNCYIT	ZNF442	121	Q9H7R0
PPSMEYCVLLFCCCI	ZNF507	901	Q8TCN5
CSPCILLYGMTLCCL	PIEZO1	466	Q92508
AVDPTCVLCMECFLG	UBR2	116	Q8IWV8
CYELTGEPLVCSMEG	PRSS50	306	Q9UI38
MEFCPCGSLYTVLEE	TBK1	86	Q9UHD2