Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD5 HLTF CHD7 RAD54L

8.87e-0637714GO:0140658
GeneOntologyMolecularFunctionribosomal protein S6 kinase activity

RPS6KB2 RPS6KA6

2.59e-047712GO:0004711
GeneOntologyBiologicalProcessnegative regulation of embryonic development

SFRP2 RPS6KA6

1.14e-052702GO:0045992
DomainSNF2_N

CHD5 HLTF CHD7 RAD54L

6.73e-0632724IPR000330
DomainSNF2_N

CHD5 HLTF CHD7 RAD54L

6.73e-0632724PF00176
DomainTim17

TIMM17B TIMM17A

1.47e-052722IPR005678
DomainTim17/Tim22/Tim23/PMP24

TIMM17B TIMM17A

4.04e-048722IPR003397
DomainTim17

TIMM17B TIMM17A

4.04e-048722PF02466
DomainHelicase_C

CHD5 HLTF CHD7 RAD54L

7.77e-04107724PF00271
DomainHELICc

CHD5 HLTF CHD7 RAD54L

7.77e-04107724SM00490
DomainHelicase_C

CHD5 HLTF CHD7 RAD54L

8.04e-04108724IPR001650
DomainHELICASE_CTER

CHD5 HLTF CHD7 RAD54L

8.32e-04109724PS51194
DomainHELICASE_ATP_BIND_1

CHD5 HLTF CHD7 RAD54L

8.32e-04109724PS51192
DomainDEXDc

CHD5 HLTF CHD7 RAD54L

8.32e-04109724SM00487
DomainHelicase_ATP-bd

CHD5 HLTF CHD7 RAD54L

8.61e-04110724IPR014001
DomainAGC-kinase_C

RPS6KB2 RPS6KA6 GRK1

1.32e-0356723IPR000961
DomainAGC_KINASE_CTER

RPS6KB2 RPS6KA6 GRK1

1.32e-0356723PS51285
DomainS_TK_X

RPS6KB2 RPS6KA6 GRK1

1.32e-0356723SM00133
Domain-

NUP133 WDR81 CORO1B DCAF5 PLXNA2 WDR24

1.79e-033337262.130.10.10
DomainWD40/YVTN_repeat-like_dom

NUP133 WDR81 CORO1B DCAF5 PLXNA2 WDR24

1.84e-03335726IPR015943
DomainChromo_domain

CHD5 CHD7

3.83e-0324722IPR023780
DomainChromo

CHD5 CHD7

4.49e-0326722PF00385
DomainKinase-like_dom

NPR1 DSTYK RPS6KB2 RPS6KA6 WDR81 STKLD1 GRK1

4.82e-03542727IPR011009
DomainCHROMO_1

CHD5 CHD7

5.19e-0328722PS00598
DomainCHROMO_2

CHD5 CHD7

5.19e-0328722PS50013
DomainChromodomain-like

CHD5 CHD7

6.75e-0332722IPR016197
DomainChromo/shadow_dom

CHD5 CHD7

7.16e-0333722IPR000953
DomainCHROMO

CHD5 CHD7

7.16e-0333722SM00298
DomainRGS

RGS14 GRK1

8.03e-0335722PF00615
DomainRGS

RGS14 GRK1

8.03e-0335722SM00315
DomainDNA/RNA_helicase_DEAH_CS

CHD5 CHD7

8.03e-0335722IPR002464
Pubmed

Oguchi disease masked by retinitis pigmentosa.

SAG GRK1

4.23e-06272221922265
Pubmed

Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods.

SAG GRK1

4.23e-06272227353443
Pubmed

Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness.

SAG GRK1

4.23e-0627229020843
Pubmed

C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor.

SAG GRK1

1.27e-05372225910054
Pubmed

Reversible congenital hypogonadotropic hypogonadism in patients with CHD7, FGFR1 or GNRHR mutations.

CHD7 GNRHR

1.27e-05372222724017
Pubmed

Arrestin competition influences the kinetics and variability of the single-photon responses of mammalian rod photoreceptors.

SAG GRK1

1.27e-05372219776273
Pubmed

Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses.

SAG GRK1

1.27e-05372210704496
Pubmed

Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas.

SAG GRK1

1.27e-05372211687607
Pubmed

Genetics of congenital hypogonadotropic hypogonadism in Denmark.

CHD7 GNRHR

2.53e-05472224732674
Pubmed

Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation.

SAG GRK1

2.53e-05472219361994
Pubmed

A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness.

SAG GRK1

2.53e-05472230947334
Pubmed

Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.

SFRP2 HCN4 PLXNA2

3.67e-053172325053429
Pubmed

Light-dependent redistribution of visual arrestins and transducin subunits in mice with defective phototransduction.

SAG GRK1

4.21e-05572212802257
Pubmed

Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses.

SAG GRK1

4.21e-05572212975449
Pubmed

Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.

ARL6IP5 OSBPL8 TFIP11 CHD7 CORO1B

4.92e-0519172531177093
Pubmed

DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.

WDR81 MED23 DCAF5 MED12

5.48e-059972434161765
Pubmed

Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria.

TIMM17B TIMM17A

6.31e-05672223263864
Pubmed

Light-dependent translocation of arrestin in the absence of rhodopsin phosphorylation and transducin signaling.

SAG GRK1

6.31e-05672212716919
Pubmed

Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.

NPR1 PLXNA2

8.82e-05772210520994
Pubmed

Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation.

MED23 MED12

8.82e-05772218691967
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

CHD5 RALGAPB OSBPL8 CHD7 ADGRV1

1.07e-0422572512168954
Pubmed

Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.

PRMT5 MED12

1.17e-04872223749998
Pubmed

Atrial natriuretic peptide signaling co-regulates lipid metabolism and ventricular conduction system gene expression in the embryonic heart.

NPR1 HCN4

1.17e-04872238235330
Pubmed

ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.

TIMM17B TIMM17A

1.17e-04872230598479
Pubmed

Role of Magmas in protein transport and human mitochondria biogenesis.

TIMM17B TIMM17A

1.17e-04872220053669
Pubmed

Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome.

CHD7 GNRHR

1.51e-04972221596839
Pubmed

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

MED23 MED12

1.88e-041072223746844
Pubmed

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

DSTYK CHD5 PLXNA2

2.18e-04567239455484
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

TIMM17B HLA-A NUP133 HLTF SFXN2 TIMM17A DCAF5

2.61e-0460672736538041
Pubmed

A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.

MED23 MED12

3.25e-041372214657022
Pubmed

CDK8 is a positive regulator of transcriptional elongation within the serum response network.

MED23 MED12

3.25e-041372220098423
Pubmed

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.

MED23 MED12

3.25e-041372227570068
Pubmed

Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development.

CHD7 PLXNA2

3.25e-041372223319608
Pubmed

Structure, function, and activator-induced conformations of the CRSP coactivator.

MED23 MED12

3.78e-041472211834832
Pubmed

Genetic and structural characterization of the human mitochondrial inner membrane translocase.

TIMM17B TIMM17A

3.78e-041472210339406
Pubmed

A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration.

EMC4 CORO1B

4.36e-041572230737405
Pubmed

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.

MED23 MED12

4.36e-041572218418385
Pubmed

Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle.

SFRP2 HCN4

4.98e-041672228287088
Pubmed

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

TIMM17B EMC4 PAIP2 ARL6IP5 TFIP11

5.18e-0431772511042152
Pubmed

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.

MED23 MED12

5.63e-041772210235266
Pubmed

SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.

SFRP2 CSPG4

5.63e-041772221478884
Pubmed

Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers.

PRMT5 MED23

5.63e-041772229384474
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

RGS14 HLA-A ARL6IP5 TTYH2 IPO13 GDPD2 GNRHR

6.01e-0469772728298427
Pubmed

Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.

RGS14 WDR81

6.33e-041872224068962
Pubmed

Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns.

SFRP2 HCN4

7.06e-041972220185795
Pubmed

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.

MED23 MED12

7.06e-041972216799563
Pubmed

Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo.

HCN4 CSPG4

7.06e-041972228111199
Pubmed

Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges.

SFRP2 CSPG4

7.06e-041972227671872
Pubmed

Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.

CSPG4 MED23

7.84e-042072236551904
Pubmed

Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.

MED23 MED12

7.84e-042072215340084
Pubmed

The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro.

MED23 MED12

9.50e-042272211867769
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

RPS6KA6 WDR81 TIMM17A CHD7 RAD54L

9.51e-0436372514691545
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

NUP133 RRP8 MTCL1 PPL

9.64e-0421072416565220
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

PRMT5 RALGAPB OSBPL8 HLTF TFIP11 RRP8 CHD7 MED23 MED12 EPB41

1.00e-031497721031527615
Pubmed

Composite co-activator ARC mediates chromatin-directed transcriptional activation.

MED23 MED12

1.04e-032372210235267
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

ARL6IP5 NUP133 IPO13 IGSF9 TFIP11 CORO1B

1.08e-0356072621653829
Pubmed

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

ARL6IP5 NUP133 OSBPL8 CORO1B EPB41

1.10e-0337572532788342
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

TIMM17B TCAF1 HLA-A PRMT5 NOB1 NUP133 HLTF SFXN2 MED12

1.13e-03125772937317656
Pubmed

Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.

SAG WDR81

1.13e-032472220705733
Pubmed

Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells.

CSPG4 DCT

1.13e-032472230348676
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

NPR1 GPR20 ADGRV1

1.23e-0310172323382219
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

TCAF1 IPO13 MTCL1

1.23e-031017239872452
Pubmed

Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth.

SFRP2 CSPG4

1.23e-032572230604742
Pubmed

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.

HLA-A PAIP2 VHLL BCAR3

1.24e-0322572423341629
Pubmed

Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression.

CDKN2C PLXNA2

1.33e-032672223506836
Pubmed

Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.

MED23 MED12

1.33e-032672234506481
Pubmed

Mediator and cohesin connect gene expression and chromatin architecture.

MED23 MED12

1.54e-032872220720539
Pubmed

Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency

CHD7 GNRHR

1.54e-032872220301509
Pubmed

A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.

MED23 MED12

1.65e-032972214638676
Pubmed

ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.

CHD5 CSPG4 CHD7

1.69e-0311372334474245
Pubmed

Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling.

SFRP2 CSPG4

1.77e-033072223349620
Pubmed

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

MED23 MED12

1.89e-033172223322298
Pubmed

Wnt/β-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation.

SFRP2 HCN4

1.89e-033172221757651
Pubmed

The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.

SAG EPB41

2.01e-033272223704327
Pubmed

AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.

TIMM17B KCNT2 DCT

2.06e-0312172331900314
Cytoband1q32.1

PPFIA4 DSTYK TIMM17A

6.71e-041087231q32.1
Cytoband1p32

CDKN2C RAD54L

8.30e-04277221p32
CytobandEnsembl 112 genes in cytogenetic band chr1q32

PPFIA4 DSTYK TIMM17A PLXNA2

1.14e-03290724chr1q32
Cytoband11q13.2

RPS6KB2 CORO1B

2.50e-034772211q13.2
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte-Oligo|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CSPG4 TTYH2 CHD7 ADGRV1 DCT

4.50e-06150725b30f52b94ce772632a1f2f5e0837db876cf92651
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CSPG4 TTYH2 CHD7 ADGRV1 DCT

4.50e-0615072505b9a9cbc5a95cdaf45d5f173e132acd4da9aa8a
DiseaseOguchi Disease 1

SAG GRK1

5.08e-062672C4551824
DiseaseOguchi disease

SAG GRK1

5.08e-062672C1306122
DiseaseOguchi disease

SAG GRK1

5.08e-062672cv:C1306122
DiseaseMalignant neoplasm of breast

CDKN2C SFRP2 KCNT2 CHD5 RPS6KB2 NUP133 KLHDC7A BCAR3 MED12 RAD54L

1.48e-0410746710C0006142
Diseasephotoreceptor cell layer thickness measurement

SAG CHD7 DCAF5 GRK1

3.64e-04148674EFO_0803370
DiseaseNight blindness, congenital stationary

SAG GRK1

6.76e-0417672C0339535
Diseasehair color

PLB1 DSTYK ADGRV1 ZNF831 DCT

7.13e-04311675EFO_0003924
DiseaseIdiopathic hypogonadotropic hypogonadism

CHD7 GNRHR

7.59e-0418672C0342384
Diseasecortical surface area measurement

CDKN2C PIGL SFRP2 DSTYK IGSF9 CHD7 MTCL1 ADGRV1 MED23 PLXNA2

8.70e-0413456710EFO_0010736
DiseaseMammary Carcinoma, Human

SFRP2 RPS6KB2 KLHDC7A BCAR3 MED12 RAD54L

1.23e-03525676C4704874
DiseaseMammary Neoplasms, Human

SFRP2 RPS6KB2 KLHDC7A BCAR3 MED12 RAD54L

1.23e-03525676C1257931
DiseaseMammary Neoplasms

SFRP2 RPS6KB2 KLHDC7A BCAR3 MED12 RAD54L

1.25e-03527676C1458155
Diseaseresponse to antiviral drug, cirrhosis of liver

MTCL1 PLXNA2

1.36e-0324672EFO_0001422, EFO_0010123
DiseaseBreast Carcinoma

SFRP2 RPS6KB2 KLHDC7A BCAR3 MED12 RAD54L

1.39e-03538676C0678222
Diseaseeosinophil measurement

HLA-A CHD7 ZNF282

1.93e-03108673EFO_0803540
Diseaseresting heart rate, chronic obstructive pulmonary disease

PLB1 ADGRV1

2.12e-0330672EFO_0000341, EFO_0004351

Protein segments in the cluster

PeptideGeneStartEntry
NFMESVPEPRPSEWD

EPB41

691

P11171
FQLDQIPFKDMWPDD

NUDT1

106

P36639
EAFSTLAPEAWPAME

CSPG4

396

Q6UVK1
MPPQDAFNSHWLVRD

CHD5

1441

Q8TDI0
DDRERPWEPAAAQME

BCAR3

481

O75815
PFHARQVAVALWPDM

GPR20

256

Q99678
MEEVPPDWERASFQQ

ADGRV1

6206

Q8WXG9
QLALWDPENLEEPMA

CORO1B

246

Q9BR76
LEMGPQPRAEAAWQF

SAG

186

P10523
WDMDPENGAFRVVLN

NPR1

411

P16066
MKDLPRWLEENPEFA

CHD7

2666

Q9P2D1
HEWFIPARDLPQTMD

PAIP2

71

Q9BPZ3
NRLVMFDPDWNPAND

RAD54L

586

Q92698
MWPCADADSIPFEDR

MTCL1

1311

Q9Y4B5
DILMAGALEDFPARW

MORC1

221

Q86VD1
VDLMDDYPASDPRWA

NUP133

566

Q8WUM0
SFMFWRNPLPNIDHE

NOB1

156

Q9ULX3
LEDARRKGMPFAQWD

PPFIA4

816

O75335
PYSQRPRAVDMDLEW

PLXNA2

1541

O75051
PEEAHRAGLIDWNMF

PPL

1671

O60437
PNSDIGWRVEFRPME

GCLC

416

P48506
CAMNAREENPWVPDD

MED23

1051

Q9ULK4
DFNLYMWRIPADPEA

DCAF5

301

Q96JK2
RWAPEFMIDTLENPA

MED12

1016

Q93074
RVPQAMVFWLPDEDR

GDPD2

381

Q9HCC8
PQDEPWDREMEVFSG

RPS6KA6

6

Q9UK32
LDNPPDMHFLDAICW

KCNT2

756

Q6UVM3
PERLPVFDEECWQLM

DSTYK

871

Q6XUX3
QFLVPMLQDFPDDCW

HCN4

436

Q9Y3Q4
ADTRPWDPLNDMIQF

OSBPL8

746

Q9BZF1
MAEPWGNELASAAAR

CDKN2C

1

P42773
LRCEAMAVPPADFQW

IGLON5

236

A6NGN9
WFDPEMLNRLSDPVN

GNRHR

291

P30968
FWMRVPLVAPEDLRD

PRMT5

151

O14744
DSDAASQRMEPRAPW

HLA-A

61

P04439
YDDEQDVWRPLARMP

KLHDC7A

511

Q5VTJ3
ASDWLAFIEPPERME

EMC4

161

Q5J8M3
RVFLMDPAWNPAAED

HLTF

926

Q14527
MNVAPACLPERDWAE

F10

336

P00742
EAQPMGEDWFLDFRV

GRK1

181

Q15835
EAAMADRPQPGWRES

FMR1NB

46

Q8N0W7
PDAWPCAVADMVRLF

IPO13

136

O94829
WPDMLECDRFPQDND

SFRP2

136

Q96HF1
EFLWRMQRPGNIDAP

ERVW-1

36

Q9UQF0
MEADLSGFNIDAPRW

SFXN2

1

Q96NB2
WDEVMQAVARLGAEP

TCAF1

691

Q9Y4C2
MNWDDLLAWRVDPPF

RPS6KB2

331

Q9UBS0
NRDFPDDPGMQWDTE

PIGL

111

Q9Y2B2
MDVNIAPLRAWDDFF

ARL6IP5

1

O75915
LDLQQPDLDGAWPMF

RUFY4

161

Q6ZNE9
WALRIPQDPIDDAMG

SH3TC1

281

Q8TE82
GAEEEMAARAAWPVL

VHLL

31

Q6RSH7
ICFWPTLMRPDFENR

ARHGAP5

1411

Q13017
EGARARDMPAQAWDL

PLB1

1171

Q6P1J6
MAWGLEAQDDPPAER

ZNF19

71

P17023
RAEEDPFRKSWMAPE

STKLD1

191

Q8NE28
DIDDDDPFNPQAWRM

TTYH2

426

Q9BSA4
PFKDMALAFPEEEWR

ZSCAN25

231

Q6NSZ9
MFEEPEWAEAAPVAA

RRP8

1

O43159
WLGEEVLAEPRPDMF

RGS14

141

O43566
FFREMNVDGDWPPLE

IGSF9

931

Q9P2J2
AIFDEWMKRFNPPAD

DCT

401

P40126
PPEMDNECVAQTWFR

RALGAPB

271

Q86X10
MEEYAREPCPWRIVD

TIMM17B

1

O60830
MEEYAREPCPWRIVD

TIMM17A

1

Q99595
WDVRRPFVPAAMFEE

WDR24

281

Q96S15
SAFADREAPWDSAPM

ZNF831

271

Q5JPB2
YPVDDDMWNLPLDSR

TMEM169

86

Q96HH4
WQPRNCDPMVDFLDS

TFIP11

496

Q9UBB9
ERMQNWTPDECIPEF

WDR81

481

Q562E7
AQEWDMDARRPMPFQ

ZNF282

56

Q9UDV7
SLDWPDFDAPIEEFM

NLRP13

286

Q86W25