Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of phosphatidylinositol dephosphorylation	MTMR1 MTMR4 MTMR9	6.16e-06	6	141	3	GO:0060304
GeneOntologyCellularComponent	interphotoreceptor matrix	RTBDN EYS IMPG2	6.57e-06	6	146	3	GO:0033165
Domain	Myotubularin-like_Pase_dom	MTMR1 MTMR4 MTMR11 MTMR9	3.19e-06	14	144	4	IPR010569
Domain	PPASE_MYOTUBULARIN	MTMR1 MTMR4 MTMR11 MTMR9	3.19e-06	14	144	4	PS51339
Domain	Myotubularin_fam	MTMR1 MTMR4 MTMR11 MTMR9	3.19e-06	14	144	4	IPR030564
Domain	Myotub-related	MTMR1 MTMR4 MTMR11 MTMR9	3.19e-06	14	144	4	PF06602
Domain	VWF_type-D	MUC5B SSPOP SUSD2	2.34e-04	16	144	3	IPR001846
Domain	VWFD	MUC5B SSPOP SUSD2	2.34e-04	16	144	3	PS51233
Domain	VWD	MUC5B SSPOP SUSD2	2.34e-04	16	144	3	SM00216
Domain	VWD	MUC5B SSPOP SUSD2	2.34e-04	16	144	3	PF00094
Domain	ARM-type_fold	MON2 TNPO1 USP34 ARFGEF2 FOCAD NF1 ARID2 IPO13 AP1G2 UTP20	3.04e-04	339	144	10	IPR016024
Domain	DCB_dom	MON2 ARFGEF2	3.51e-04	4	144	2	IPR032629
Domain	Sec7_C	MON2 ARFGEF2	3.51e-04	4	144	2	IPR015403
Domain	DUF1981	MON2 ARFGEF2	3.51e-04	4	144	2	PF09324
Domain	Sec7_N	MON2 ARFGEF2	3.51e-04	4	144	2	IPR032691
Domain	Sec7_N	MON2 ARFGEF2	3.51e-04	4	144	2	PF12783
Domain	DCB	MON2 ARFGEF2	3.51e-04	4	144	2	PF16213
Domain	-	MORC1 SMCHD1 TOP2B	4.65e-04	20	144	3	3.30.565.10
Domain	HATPase_C	MORC1 SMCHD1 TOP2B	5.39e-04	21	144	3	IPR003594
Domain	Sushi	CSMD2 CSMD3 SUSD2 CSMD1	6.88e-04	52	144	4	PF00084
Domain	CCP	CSMD2 CSMD3 SUSD2 CSMD1	7.95e-04	54	144	4	SM00032
Domain	SUSHI	CSMD2 CSMD3 SUSD2 CSMD1	9.12e-04	56	144	4	PS50923
Pathway	WP_PHOSPHOINOSITIDES_METABOLISM	MTMR1 MTMR4 MTMR11 PLCG1 MTMR9	2.79e-05	49	103	5	M40046
Pubmed	Identification of two new members of the CSMD gene family.	CSMD2 CSMD3 CSMD1	7.55e-08	3	148	3	12906867
Pubmed	Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.	MTMR1 MTMR4 MTMR11 MTMR9	1.52e-07	12	148	4	16787938
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	CYP1A2 ABCC4 ZNF230 TEP1 STAT1 PCTP FANCA JAK3 IGF2R MTHFR TP63 NOS2	2.81e-07	421	148	12	19692168
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP53 USP34 ABCA2 PDPR USP28 SMCHD1 FNDC3A NUP155 SMG7 SUPT6H ANAPC2 IPO13 HMGXB3	4.75e-07	529	148	13	14621295
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	ABCC4 ZNF230 TEP1 STAT1 PCTP FANCA JAK3 IGF2R MTHFR TP63 NOS2	6.60e-07	374	148	11	19625176
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	ABCC4 ZNF230 TEP1 STAT1 PCTP FANCA JAK3 IGF2R MTHFR TP63 NOS2	7.91e-07	381	148	11	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	ABCC4 ZNF230 TEP1 STAT1 PCTP FANCA JAK3 IGF2R MTHFR TP63 NOS2	8.11e-07	382	148	11	19170196
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TNPO1 USP34 SMCHD1 BEND3 CHD7 LCP1 RAD50 IGF2R NF1 NUP155 ANAPC1 SUPT6H UTP20 PTCD3	8.61e-07	653	148	14	22586326
Pubmed	JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway.	STAT1 JAK3 NOS2	4.16e-06	8	148	3	19414010
Pubmed	Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.	MTMR1 MTMR4 MTMR9	8.87e-06	10	148	3	9736772
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	USP34 ABCC1 COL6A1 ABCC4 ABCA2 CD109 ARFGEF2 NPC2 RXYLT1 FANCA IGF2R NF1 SLITRK5 OSBPL9 IPO13 UTP20 TIMELESS	1.52e-05	1201	148	17	35696571
Pubmed	IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression.	IRAK1 STAT1	1.80e-05	2	148	2	12856330
Pubmed	Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma.	ABCC1 ABCC4	1.80e-05	2	148	2	24024181
Pubmed	Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells.	USP28 TP63	1.80e-05	2	148	2	32128997
Pubmed	Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2).	ABCC1 ABCA2	1.80e-05	2	148	2	15999530
Pubmed	Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1.	SYNE1 CSMD1	1.80e-05	2	148	2	24387768
Pubmed	Loss of CSMD1 or 2 may contribute to the poor prognosis of colorectal cancer patients.	CSMD2 CSMD1	1.80e-05	2	148	2	24408017
Pubmed	Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines.	ABCC1 ABCC4	1.80e-05	2	148	2	33081264
Pubmed	Human endogenous retrovirus W env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase.	ERVW-1 NOS2	1.80e-05	2	148	2	28656540
Pubmed	Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer.	STAT1 TP63	1.80e-05	2	148	2	38509096
Pubmed	Statin-mediated correction of STAT1 signaling and inducible nitric oxide synthase expression in cystic fibrosis epithelial cells.	STAT1 NOS2	1.80e-05	2	148	2	12948935
Pubmed	An unexpected protein interaction promotes drug resistance in leukemia.	MPP1 ABCC4	1.80e-05	2	148	2	29146910
Pubmed	Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages.	STAT1 NOS2	1.80e-05	2	148	2	17689680
Pubmed	Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity.	HTR6 NF1	1.80e-05	2	148	2	27791021
Pubmed	A genetic association study of CSMD1 and CSMD2 with cognitive function.	CSMD2 CSMD1	1.80e-05	2	148	2	27890662
Pubmed	gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway.	NEDD4 AP1G2	1.80e-05	2	148	2	18772139
Pubmed	The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.	CSMD2 CSMD1	1.80e-05	2	148	2	21439553
Pubmed	The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4.	NEDD4 MTMR4	1.80e-05	2	148	2	19125695
Pubmed	Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis.	ABCC1 ABCC4	1.80e-05	2	148	2	24130369
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	MON2 USP34 MMS22L SMCHD1 PRAMEF20 CHD7 OSBPL9 IFFO2 NOS2	2.73e-05	363	148	9	14691545
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP53 USP34 USP28 RAD50 NF1 TIMELESS	4.14e-05	147	148	6	29576527
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	MON2 MPP1 USP34 USP28 CHD7 ZNF217 RAD50 SMG7 ANAPC1 SUPT6H ARID2	4.66e-05	588	148	11	38580884
Pubmed	Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).	ABCC1 ABCC4	5.38e-05	3	148	2	16156793
Pubmed	Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells.	ABCC1 ABCC4	5.38e-05	3	148	2	26600514
Pubmed	Intragraft iNOS induction during human liver allograft rejection depresses cytochrome p450 activity.	CYP1A2 NOS2	5.38e-05	3	148	2	15349722
Pubmed	H3K27 acetylation activated-COL6A1 promotes osteosarcoma lung metastasis by repressing STAT1 and activating pulmonary cancer-associated fibroblasts.	COL6A1 STAT1	5.38e-05	3	148	2	33391546
Pubmed	Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men.	MTHFR NOS2	5.38e-05	3	148	2	15494775
Pubmed	STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation.	STAT1 NOS2	5.38e-05	3	148	2	12788789
Pubmed	Association of SRC-related kinase Lyn with the interleukin-2 receptor and its role in maintaining constitutive phosphorylation of JAK/STAT in human T-cell leukemia virus type 1-transformed T cells.	JAK3 IL2RB	5.38e-05	3	148	2	21345943
Pubmed	Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1.	STAT1 PLCG1	5.38e-05	3	148	2	17561467
Pubmed	Phosphorylated TP63 induces transcription of RPN13, leading to NOS2 protein degradation.	TP63 NOS2	5.38e-05	3	148	2	20959455
Pubmed	Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR.	CYP1A2 MTHFR	5.38e-05	3	148	2	36011409
Pubmed	Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception.	ABCC1 ABCC4	5.38e-05	3	148	2	15886284
Pubmed	ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes.	NEDD4 TP63	5.38e-05	3	148	2	23589096
Pubmed	Single nucleotide polymorphisms of the genes IL-2, IL-2RB, and JAK3 in patients with cutaneous leishmaniasis caused by Leishmania (V.) guyanensis in Manaus, Amazonas, Brazil.	JAK3 IL2RB	5.38e-05	3	148	2	31393896
Pubmed	Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).	STAT1 JAK3	5.38e-05	3	148	2	21383241
Pubmed	ΔNp63α/IRF6 interplay activates NOS2 transcription and induces autophagy upon tobacco exposure.	TP63 NOS2	5.38e-05	3	148	2	21129360
Pubmed	Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier.	ABCC1 ABCC4	5.38e-05	3	148	2	25986174
Pubmed	Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages.	STAT1 NOS2	5.38e-05	3	148	2	18274639
Pubmed	C6 glioma cell insoluble matrix components enhance interferon-gamma-stimulated inducible nitric-oxide synthase/nitric oxide production in BV2 microglial cells.	STAT1 NOS2	5.38e-05	3	148	2	17981810
Pubmed	A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages.	STAT1 NOS2	5.38e-05	3	148	2	24443556
Pubmed	Estrogen regulates transcription factors STAT-1 and NF-kappaB to promote inducible nitric oxide synthase and inflammatory responses.	STAT1 NOS2	5.38e-05	3	148	2	19890039
Pubmed	Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo.	NEDD4 TP63	5.38e-05	3	148	2	15908775
Pubmed	Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells.	JAK3 PLCG1	5.38e-05	3	148	2	17015722
Pubmed	ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.	ABCC1 ABCC4	5.38e-05	3	148	2	21799180
Pubmed	An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons.	ZNF93 ZNF91	5.38e-05	3	148	2	25274305
Pubmed	Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer.	STAT1 FANCA JAK3 NOS2	5.75e-05	49	148	4	19012493
Pubmed	Identification of a genomic reservoir for new TRIM genes in primate genomes.	TRIM49 TRIM49C TRIM49D1	6.96e-05	19	148	3	22144910
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	USP34 SYNE1 ANGEL1 NUP155 IPO13	7.44e-05	101	148	5	9872452
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	MON2 TNPO1 USP34 SMCHD1 CD109 IRAK1 MTMR1 LCP1 RAD50 MTMR4 NUP155 PPP5C PLCG1 PTCD3	7.61e-05	974	148	14	28675297
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 USP34 ABCA2 LRWD1 ARFGEF2 IRAK1 TEP1 FANCA FOCAD JAK3 IGF2R MTHFR AP1G2 HMGXB3 PLCG1	7.92e-05	1105	148	15	35748872
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	USP34 COL6A1 IRAK1 BEND3 CHD7 ZNF217 RAD50 ZFHX4 ANAPC1	8.09e-05	418	148	9	34709266
Pubmed	Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.	CYP1A2 ABCA2 MTHFR	8.16e-05	20	148	3	21072184
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	MTMR1 MTMR4 MTMR11 ANAPC1 ANAPC2 MTMR9	8.41e-05	167	148	6	25659891
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	KLK10 FANCA RAD50 IGF2R MTHFR NOS2	9.27e-05	170	148	6	19064572
Pubmed	Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.	ABCC1 ABCC4 ABCA2	9.49e-05	21	148	3	23137377
Pubmed	Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.	ABCC4 MTHFR	1.07e-04	4	148	2	34331561
Pubmed	The expression and significance of MRP1, LRP, TOPOIIβ, and BCL2 in tongue squamous cell carcinoma.	ABCC1 TOP2B	1.07e-04	4	148	2	21793937
Pubmed	Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation.	ANAPC1 ANAPC2	1.07e-04	4	148	2	11438673
Pubmed	Regulation of the Jak/STAT signalling pathway.	STAT1 JAK3	1.07e-04	4	148	2	8593242
Pubmed	Anaphylactic shock depends on PI3K and eNOS-derived NO.	GUCY1A1 NOS2	1.07e-04	4	148	2	16886062
Pubmed	mRNA expression profile of multidrug-resistant genes in acute lymphoblastic leukemia of children, a prognostic value for ABCA3 and ABCA2.	ABCC1 ABCA2	1.07e-04	4	148	2	24145140
Pubmed	Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier.	ABCC1 ABCC4	1.07e-04	4	148	2	26507673
Pubmed	Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells.	JAK3 IL2RB	1.07e-04	4	148	2	9520455
Pubmed	IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB.	STAT1 NOS2	1.07e-04	4	148	2	26677135
Pubmed	Ligand-independent homomeric and heteromeric complexes between interleukin-2 or -9 receptor subunits and the gamma chain.	JAK3 IL2RB	1.07e-04	4	148	2	18829468
Pubmed	Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host.	STAT1 NOS2	1.07e-04	4	148	2	16424049
Pubmed	The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages.	STAT1 NOS2	1.07e-04	4	148	2	16284791
Pubmed	Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy.	ABCC1 ABCC4	1.07e-04	4	148	2	18690847
Pubmed	Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.	JAK3 IL2RB	1.07e-04	4	148	2	9553136
Pubmed	JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling.	JAK3 IL2RB	1.07e-04	4	148	2	11133764
Pubmed	cGMP transport by vesicles from human and mouse erythrocytes.	ABCC1 ABCC4	1.07e-04	4	148	2	17229149
Pubmed	SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation.	JAK3 IL2RB	1.07e-04	4	148	2	10373548
Pubmed	Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.	JAK3 IL2RB	1.07e-04	4	148	2	7973659
Pubmed	Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.	JAK3 IL2RB	1.07e-04	4	148	2	7973658
Pubmed	NEDD4-2 associates with gamma(c) and regulates its degradation rate.	NEDD4 IL2RB	1.07e-04	4	148	2	19615332
Pubmed	Human skeletal muscle drug transporters determine local exposure and toxicity of statins.	ABCC1 ABCC4	1.07e-04	4	148	2	19940267
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TNPO1 DNHD1 SYNE1 SMCHD1 TARS2 STAT1 RAD50 IGF2R NF1 NUP155 PPP5C ANAPC1 SUPT6H UTP20 PLCG1 TOP2B PTCD3	1.26e-04	1425	148	17	30948266
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	TNPO1 LRWD1 SYNE1 SMCHD1 IRAK1 STAT1 RAD50 HOOK3 IGF2R NF1 NUP155 SUPT6H UTP20 TOP2B	1.28e-04	1024	148	14	24711643
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	BEND3 RAD50 ANAPC1 ARID2 ANAPC2	1.43e-04	116	148	5	21549307
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	MON2 TNPO1 TARS2 RAD50 NUP155 ANAPC1 SUPT6H ANAPC2 TIMELESS PTCD3	1.52e-04	560	148	10	35241646
Pubmed	Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cells.	STAT1 EGR3	1.78e-04	5	148	2	29728568
Pubmed	Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.	JAK3 IL2RB	1.78e-04	5	148	2	23341462
Pubmed	Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus.	STAT1 NOS2	1.78e-04	5	148	2	16148148
Pubmed	Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense.	STAT1 NOS2	1.78e-04	5	148	2	25738463
Pubmed	Cutting edge: JAK3 activation and rescue of T cells from HIV gp120-induced unresponsiveness.	JAK3 IL2RB	1.78e-04	5	148	2	9637477
Pubmed	Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1.	PLCG1 EPHB1	1.78e-04	5	148	2	7689724
Pubmed	Etiology of esophageal atresia and tracheoesophageal fistula: "mind the gap".	CHD7 FANCA	1.78e-04	5	148	2	20425471
Pubmed	IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes.	JAK3 IL2RB	1.78e-04	5	148	2	18990450
Pubmed	Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy.	STAT1 JAK3	1.78e-04	5	148	2	19017763
Interaction	GYPA interactions	TNPO1 FNDC3A STAT1 FOCAD NF1 UTP20 TIMELESS GPRC5D ZNF292	3.82e-06	174	141	9	int:GYPA
Interaction	NPTN interactions	MON2 TNPO1 MMS22L GCFC2 TUBB8 ARFGEF2 FANCA FOCAD ANAPC2 IPO13 UTP20	4.26e-06	278	141	11	int:NPTN
Interaction	GPR45 interactions	MON2 TNPO1 MMS22L ABCA2 TUBB8 MYO19 IRAK1 TARS2 STAT1 FANCA IPO13	8.77e-06	300	141	11	int:GPR45
Interaction	FAM234A interactions	TNPO1 TUBB8 ARFGEF2 NF1 IPO13 UTP20 GPRC5D	2.98e-05	126	141	7	int:FAM234A
Interaction	MFSD4A interactions	MON2 TNPO1 TUBB8 ARFGEF2 IRAK1 MFSD4A STAT1 FANCA IPO13	3.00e-05	225	141	9	int:MFSD4A
Interaction	HLA-B interactions	MON2 ABCC1 ABCA2 TUBB8 ARFGEF2 IRAK1 STAT1 FANCA IPO13	4.80e-05	239	141	9	int:HLA-B
Interaction	KLRB1 interactions	ABCC1 ARFGEF2 IRAK1 TARS2 IPO13	4.88e-05	57	141	5	int:KLRB1
Cytoband	19p12	ZNF93 ZNF486 RTBDN ZNF431 ZNF91	1.15e-05	90	148	5	19p12
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR1 MTMR4 MTMR11 MTMR9	1.24e-06	15	102	4	903
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CSMD2 CSMD3 SUSD2 CSMD1	3.00e-04	57	102	4	1179
Coexpression	MIKKELSEN_IPS_ICP_WITH_H3K27ME3	SLAMF8 RTBDN GFI1B THBS2 KCNJ9	1.30e-05	55	144	5	M1970
Coexpression	MIKKELSEN_IPS_ICP_WITH_H3K27ME3	SLAMF8 RTBDN GFI1B THBS2 KCNJ9	1.30e-05	55	144	5	MM842
Coexpression	NIKOLSKY_MUTATED_AND_AMPLIFIED_IN_BREAST_CANCER	ARFGEF2 CHD7 CSMD3 FANCA HOOK3 ZFHX4	1.36e-05	94	144	6	M18108
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	MON2 ABCC4 MMS22L SMCHD1 ARFGEF2 NUP155 ARID2 MCTP2 ZNF292	1.54e-08	191	147	9	9454f642c3621370fa23640b631301346b300950
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	USP28 SYNE1 LCP1 RAD50 SAMD9L IGF2R TIGIT PLCG1 IL2RB	2.29e-08	200	147	9	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	MON2 ABCC4 MMS22L SMCHD1 NUP155 ARID2 MCTP2 ZNF292	2.00e-07	186	147	8	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	COVID-19_Mild-PLT_2\|World / Disease Group and Platelet Clusters	SLAMF8 USP53 DNHD1 USP28 CHD7 TARS2 PLCG1	1.52e-06	169	147	7	6abfdc8b437f19c03b408bedc245059d28c6ba6a
ToppCell	CF-Myeloid-Neutrophil\|Myeloid / Disease state, Lineage and Cell class	CD177 SMCHD1 LCP1 EGR3 MCTP2 ZNF292 EPHB1	1.92e-06	175	147	7	8020c3a34f77e68e8149f87481fb1dddd2ac675e
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC5B CSMD3 SSPOP SLITRK2 ZFHX4 CSMD1 HYDIN	2.68e-06	184	147	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC5B CSMD3 SSPOP SLITRK2 ZFHX4 CSMD1 HYDIN	2.68e-06	184	147	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC5B CSMD3 SSPOP SLITRK2 ZFHX4 CSMD1 HYDIN	2.68e-06	184	147	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	MON2 ABCC4 MMS22L SMCHD1 NUP155 MCTP2 ZNF292	2.78e-06	185	147	7	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	COVID-19-kidney-Myeloid\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CD177 SMCHD1 LCP1 DENND3 EGR3 MCTP2 EPHB1	3.55e-06	192	147	7	0b9d22a222f1201e375f8e55cace9ef939febae4
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD177 SMCHD1 LCP1 LRG1 DENND3 EGR3 MCTP2	3.80e-06	194	147	7	b04cbd240c59755ef7bdeb17fee3028caef6dedb
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD177 SMCHD1 LCP1 LRG1 DENND3 EGR3 MCTP2	3.80e-06	194	147	7	744fd4580942183a1058717d0c3ac86483e366ed
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MPP1 ABCC4 TUBB8 LCP1 SSPOP EGR3 ALPK2	4.21e-06	197	147	7	b597c292fc1cb381a4325fed15a32966c38def28
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD177 SYNE1 SMCHD1 LRG1 DENND3 IGF2R MCTP2	4.65e-06	200	147	7	6beabd5bad042d4d65c89c2f537c7376230f7c08
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_granulocytic\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD177 SYNE1 SMCHD1 LRG1 DENND3 IGF2R MCTP2	4.65e-06	200	147	7	026495aa7f1e7528a01d9199475cfc393677fc60
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Dendritic_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLAMF8 XCR1 LCP1 TIGIT MTMR9 EPHB1	1.19e-05	153	147	6	c81a88d3f707487c511020d3960a1c41e706c6a0
ToppCell	COPD-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	ABCC1 CD177 SMCHD1 TIGIT IL2RB ZNF292	2.99e-05	180	147	6	51a12fbad5fa7bb12e6d616a02ff9b5141e2b063
ToppCell	Control-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	ABCC1 CD177 SMCHD1 JAK3 TIGIT IL2RB	2.99e-05	180	147	6	47036eee4c128fbb443d1fc767b4de5cced93f0e
ToppCell	Adult-Immune-natural_killer_cell-D231\|Adult / Lineage, Cell type, age group and donor	ABCA2 JAK3 TIGIT IL2RB MCTP2 SPIC	3.18e-05	182	147	6	dbf47bf4754d8ec3bc3ab1d5be7a6c47a7afbf43
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	SMCHD1 ZNF217 STAT1 SAMD9L PARP12 ZNF292	3.28e-05	183	147	6	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	MMS22L MTMR1 TEP1 DENND3 FANCA MBTPS2	3.38e-05	184	147	6	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	IPF-Lymphoid-T_Regulatory\|IPF / Disease state, Lineage and Cell class	ABCC1 CD177 JAK3 TIGIT IL2RB ZNF292	3.48e-05	185	147	6	221cbd09d94cc0947d0e3c1aa14716d17cb2068d
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-Treg\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ABCC1 CD177 SMCHD1 JAK3 TIGIT IL2RB	3.48e-05	185	147	6	a86a3a1a187a4d8d7762bc6d3dcb22c982178d22
ToppCell	IPF-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	ABCC1 CD177 JAK3 TIGIT IL2RB ZNF292	3.48e-05	185	147	6	77fbecdab10bacc005b1c7e22ca414cfecef13c1
ToppCell	Control-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	CPNE2 ABCC1 CD177 TIGIT TP63 ZNF292	3.48e-05	185	147	6	e481cacda0b6b25f5f0062b962df9a442053ac30
ToppCell	droplet-Lung-nan-18m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD109 THBS2 GUCY1A1 SLITRK5 CORIN CSMD1	3.59e-05	186	147	6	b58db5abdd3e9f0214b198c3cbd09b0b3c321eab
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD109 THBS2 GUCY1A1 SLITRK5 CORIN CSMD1	3.59e-05	186	147	6	cd6502bbf9dce318fdbb4965d49df8951e5f795c
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD109 THBS2 GUCY1A1 SLITRK5 CORIN CSMD1	3.70e-05	187	147	6	8bd635abdee5d5a12a3f7bf74eab4282e8e40741
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD109 THBS2 GUCY1A1 SLITRK5 CORIN CSMD1	3.70e-05	187	147	6	3cb8cd7f7a4306ff74d1f7f9964014008ec1c6a0
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	MON2 USP34 SMCHD1 IGF2R NF1 ARID2	3.81e-05	188	147	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ARFGEF2 ZNF217 THBS2 IGF2R NTM PLCG1	3.81e-05	188	147	6	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	cellseq-Immune-Hematopoietic-Granulocytic-Neutrophil\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SMCHD1 LCP1 LRG1 JAK3 EGR3 MCTP2	3.93e-05	189	147	6	fedab592be1d6520325b8c1b659b0a4dc3f4fe4d
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD177 SYNE1 CSMD3 LRG1 DENND3 IGF2R	4.16e-05	191	147	6	d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A1 THBS2 ZFHX4 GUCY1A1 NTM CLUL1	4.29e-05	192	147	6	20ede290e01ad574afd122d72b59dbc52c595fad
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CHD7 ZNF441 FANCA SLITRK5 TIMELESS HYDIN	4.29e-05	192	147	6	d6f656be2698bd215717d35f4e7ab727c08c61e0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABCA2 SYNE1 LCP1 IGF2R IFFO2 IL2RB	4.41e-05	193	147	6	b53ffef20f918b7d1e9d3924562691d13245e2dd
ToppCell	control-Myeloid-Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CD177 SMCHD1 LRG1 STAT1 SAMD9L PARP12	4.54e-05	194	147	6	267e213e8efe53aadfe553a2ca010a0e3b4b8939
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD177 LCP1 LRG1 DENND3 EGR3 MCTP2	4.54e-05	194	147	6	d2f6c8900b5c448eede8047ca964e94b19bd6ca5
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD177 SYNE1 SMCHD1 STAT1 TIGIT IL2RB	4.67e-05	195	147	6	6ddce0cce14f737e45b8f57802c6a8ad07686262
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_2\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	CD177 SYNE1 SMCHD1 STAT1 TIGIT IL2RB	4.67e-05	195	147	6	e6212373cc3c6c98f76e104e2ac1afa68965cc5f
ToppCell	COVID-19_Severe\|World / Disease condition and Cell class	CD177 SYNE1 LCP1 LRG1 IGF2R MCTP2	4.67e-05	195	147	6	22f56ccb81967bff54a1f90e949a8dfc2ce0e4ab
ToppCell	Bronchial_Biopsy-Mesenchymal-Fibroblasts\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	COL6A1 F10 THBS2 GUCY1A1 NTM CORIN	4.67e-05	195	147	6	5870b2956d50d6550a3174a220a6cc70c5538d70
ToppCell	Mild_COVID-19-T/NK-CD4+_T_2\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	CD177 SYNE1 SMCHD1 STAT1 TIGIT IL2RB	4.81e-05	196	147	6	e50d03d8428dc4526e4607b6b4e99f0812a0ad31
ToppCell	Bronchial_Biopsy-Mesenchymal\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	COL6A1 F10 THBS2 GUCY1A1 NTM CORIN	4.81e-05	196	147	6	d37d821229dce716a05c2a5865415e10f79032de
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_ILC-NK_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	4.81e-05	196	147	6	78b28b263deaa43590b38597186222c6447ad25f
ToppCell	control-Others-Megakaryocytes\|Others / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SMCHD1 LCP1 LRG1 DENND3 IGF2R EPHB1	4.81e-05	196	147	6	10d914f1612622f64ac71da04e1995a854a4bec9
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_ILC\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	4.81e-05	196	147	6	3e78e307c9c991c1aadc85c61d401431cf75eaec
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	4.81e-05	196	147	6	f0566f2ef96584ed6d9247b149218376fb509915
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MPP1 ABCC4 NPC2 DENND3 SAMD9L EGR3	4.81e-05	196	147	6	e54c08f88779f9fd453a4f5b85aed1f460d8a1e1
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ABCA2 SYNE1 PLCG1 MCTP2 IMPG2 ZNF292	4.95e-05	197	147	6	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABCA2 USP28 SYNE1 TIGIT IL2RB MCTP2	4.95e-05	197	147	6	a44501cac24c2f4a53b413e92bd060eed6514616
ToppCell	Severe-CD8+_T_activated\|Severe / Disease group and Cell class	ABCA2 LCP1 SAMD9L TIGIT IL2RB MCTP2	4.95e-05	197	147	6	bb1e3e1d841c2c7141eb1099e7755860b168b6fc
ToppCell	BL\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SMCHD1 LCP1 STAT1 JAK3 SAMD9L IGF2R	4.95e-05	197	147	6	1acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 SMCHD1 TIGIT PLCG1 IL2RB MCTP2	4.95e-05	197	147	6	927bf36bad3bcb7346c13b660777c1c0de7dc322
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 SMCHD1 TIGIT PLCG1 IL2RB MCTP2	4.95e-05	197	147	6	3e09158507df08c08e08613ce23617206280c911
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	SYNE1 LCP1 SAMD9L SUPT6H PLCG1 PARP12	5.09e-05	198	147	6	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	healthy_donor-Lymphocytic-ILC-NK_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	SYNE1 LCP1 IGF2R TIGIT IL2RB MCTP2	5.09e-05	198	147	6	d7053a898e04478c577381085f615edaad3cdc5b
ToppCell	Severe-CD8+_T_activated\|World / Disease group and Cell class	ABCA2 LCP1 SAMD9L TIGIT IL2RB MCTP2	5.09e-05	198	147	6	5ff98c9b6c8c6863767b76c7745f263568f86acc
ToppCell	healthy_donor-Lymphocytic-ILC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	SYNE1 LCP1 IGF2R TIGIT IL2RB MCTP2	5.09e-05	198	147	6	aa33be29e26f1b8facfc894413099083ae3bbb1b
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MON2 USP34 SYNE1 SMCHD1 MCTP2 ZNF292	5.23e-05	199	147	6	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	COVID_non-vent-Lymphocytic-ILC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	ABCA2 USP28 SYNE1 IGF2R TIGIT IL2RB	5.23e-05	199	147	6	df4f7d5be099e3e6054f3b812ccf70251664e4c0
ToppCell	COVID-19_Moderate-NK\|World / disease group, cell group and cell class	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	5.23e-05	199	147	6	c41b67b760831c7d5e19fabcc932a056dc560f93
ToppCell	COVID-19_Moderate-NK\|COVID-19_Moderate / disease group, cell group and cell class	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	5.23e-05	199	147	6	e0e83ba511957be9ad3413460dcb6b7d7b65dd18
ToppCell	COVID_non-vent-Lymphocytic-ILC-NK_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	ABCA2 USP28 SYNE1 IGF2R TIGIT IL2RB	5.23e-05	199	147	6	ed35d747f11f6ea6a5cb7061057f0a98d9e0db99
ToppCell	distal-Epithelial-Alveolar_Epithelial_Type_1-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYP1A2 KLK10 ERVW-1 NTM SUSD2 CST6	5.23e-05	199	147	6	c1daa481f88d5281b6b5ea8ec8bb70cc0907d613
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	5.23e-05	199	147	6	4820f5bcd7bc34c2ebf6a3422cc8eb383a3b5a4e
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD177 SYNE1 LCP1 LRG1 DENND3 IGF2R	5.23e-05	199	147	6	b7af2b4fe6866cc8c78cf0f78390aab1b1b389ba
ToppCell	IPF-Myeloid-Macrophage\|Myeloid / Disease state, Lineage and Cell class	MPP1 CD109 IRAK1 FNDC3A NPC2 CST6	5.23e-05	199	147	6	3c2b362d5e824e1a04830e70352f8818de984174
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	5.23e-05	199	147	6	eb05ccae5187e4701bbbe6d714a6d2808fbcf306
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	5.23e-05	199	147	6	10c8729b779073c3bf808e85958d59147f0be5c5
ToppCell	Control-NK\|Control / Disease condition and Cell class	USP28 SYNE1 LCP1 IGF2R IL2RB MCTP2	5.23e-05	199	147	6	f3316fb97c6065286ffd22a0ad9fe7aa5b3b5650
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	5.23e-05	199	147	6	867fd292f3879982422e840e087bfdb3b21a8715
ToppCell	COVID-19-COVID-19_Mild-Myeloid-Neutrophil\|COVID-19_Mild / Disease, condition lineage and cell class	SMCHD1 LRG1 DENND3 IGF2R EGR3 MCTP2	5.23e-05	199	147	6	9f6b6731186ef399f952a75879eba66fd8ed3494
ToppCell	COVID-19-lung\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NPC2 LCP1 STAT1 SAMD9L MCTP2 PARP12	5.23e-05	199	147	6	155b03b859157013e9142e9248551369127d9204
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	5.23e-05	199	147	6	5e9fe852a70546c9d235414a2c26ca3e67ba6eb9
ToppCell	Control-Lymphoid_T/NK-NK\|Control / Disease group, lineage and cell class	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	5.23e-05	199	147	6	94b2693a8378b9b2c58c6aebb2c6658d75b2e3de
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MPP1 CD109 ARFGEF2 FNDC3A NPC2 LCP1	5.23e-05	199	147	6	379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	5.23e-05	199	147	6	d2c9fb69e5ef75778a1652da293fcf8cfa7ecfcc
ToppCell	Control-Control-Lymphocyte-T/NK-NK\|Control / Disease, condition lineage and cell class	USP28 SYNE1 IGF2R TIGIT IL2RB MCTP2	5.38e-05	200	147	6	c64c27dbf4df42ca2ad2bd94b50fab87b4050ef3
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SMCHD1 STAT1 SAMD9L ITSN2 ZNF292	5.38e-05	200	147	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	mild-NK\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP28 SYNE1 SAMD9L IGF2R IL2RB MCTP2	5.38e-05	200	147	6	a11fb1d7e124c352eb73fea0e0ec0fed577c97f7
ToppCell	COVID-19_Severe-NK_activated\|COVID-19_Severe / Disease condition and Cell class	USP28 SYNE1 LCP1 SAMD9L IL2RB MCTP2	5.38e-05	200	147	6	f1f6c7f7f75f891c9ccf6bf58f4d65b9cf10bbd8
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic-neutrophil\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD177 SYNE1 LCP1 LRG1 DENND3 IGF2R	5.38e-05	200	147	6	808571d74bb5c4d765ff13fc9393f88020d4e90d
ToppCell	Control-B_activate-7\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	STAT1 EGR3 CORIN IL2RB IMPG2	7.17e-05	130	147	5	d3343c19d61928f18e7d707eda5dec6e0fd2a9a2
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	CSMD2 CSMD3 EYS NTM CSMD1	1.24e-04	146	147	5	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	COVID-19_Moderate-multiplets\|COVID-19_Moderate / disease group, cell group and cell class	SLAMF8 XCR1 ABCA2 SYNE1 PLCG1	1.28e-04	147	147	5	baf15c773d7751bc6f64d4974a22738626f2b3ff
ToppCell	PND01-Immune-Immune_Myeloid-Granulocytic-Neutrophil\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CPNE2 CD177 SYNE1 LCP1 LRG1	1.36e-04	149	147	5	4de52569611e63a780cde9bd111d6d9c11a05a11
ToppCell	PND01-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CPNE2 CD177 SYNE1 LCP1 LRG1	1.36e-04	149	147	5	c957ac23ad6343eacce7e6be4a6d3ac043af4f86
ToppCell	Immune_cells-Neutrophils\|World / Lineage and Cell class	CD177 SYNE1 LCP1 LRG1 SAMD9L	1.45e-04	151	147	5	056301bedb4285e797250b55d79ee1790a17516d
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-Klrb1a/b/c(-)_NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD177 SYNE1 LRG1 TIGIT IL2RB	1.54e-04	153	147	5	cb144b8c487286384b47fdff88ff98fcf0508899
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLAMF8 CPNE2 XCR1 LCP1 LRG1	1.59e-04	154	147	5	ad6cfd7fc02f4201863dc8e12e353395c86c5fdb
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CPNE2 TMC7 CD177 TIGIT TP63	1.59e-04	154	147	5	1f8d127b657976656e4ec292f26d619943533b86
ToppCell	COVID-19_Moderate-multiplets\|World / disease group, cell group and cell class	SLAMF8 XCR1 ABCA2 SYNE1 PLCG1	1.69e-04	156	147	5	afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_A\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	USP28 PIGZ F10 EGR3 IL2RB	1.74e-04	157	147	5	542944030cd9b3f3559e64f9f6598694d74003c0
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MORC1 SMCHD1 F10 PCTP TIMELESS	1.74e-04	157	147	5	eea53cf8d8a607264e1ee00b7a97c94bcf2ac80d
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLAMF8 CPNE2 XCR1 LCP1 LRG1	1.79e-04	158	147	5	e0b862e4b9ebaa12869640b5d18d5fa852861bef
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MFSD4A TIGIT KCNJ9 SRL IL2RB	1.85e-04	159	147	5	95128a2367ff2a639b21913c0350924c174faef8
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	CSMD2 CSMD3 EYS NTM CSMD1	1.85e-04	159	147	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABCA2 ERVW-1 SSPOP TIGIT IL2RB	1.90e-04	160	147	5	50d4f867d021abcfeb49e6812bcfd5bb57466a31
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CPNE2 TMC7 CD177 TIGIT TP63	1.90e-04	160	147	5	c2b5fadb4bac17fafc08831f6d3f4ff96ada7e70
Drug	alpha-viniferin	ABCC1 NOS2 TOP2B	9.87e-07	4	144	3	CID000196402
Drug	Theobromine [83-67-0]; Up 200; 22.2uM; MCF7; HT_HG-U133A	MPP1 ABCC1 COL6A1 ABCA2 ZNF230 TEP1 DENND3 NF1 PLCG1	4.52e-06	196	144	9	4958_UP
Drug	dimethoxyphenol	CYP1A2 SYNE1 TOP2B	4.89e-06	6	144	3	CID000078828
Drug	Midecamycin [35457-80-8]; Up 200; 5uM; HL60; HG-U133A	ANGEL1 MTMR1 STAT1 NEDD4 FANCA MTMR4 ZFHX4 SUPT6H TP63	4.91e-06	198	144	9	2026_UP
Drug	Benserazide hydrochloride [14919-77-8]; Down 200; 13.6uM; PC3; HT_HG-U133A	COL6A1 ARFGEF2 MTMR1 FNDC3A MUC5B DENND3 MBTPS2 AP1G2	3.37e-05	194	144	8	6722_DN
Drug	Flecainide acetate [54143-56-5]; Up 200; 8.4uM; PC3; HT_HG-U133A	COL6A1 MTMR1 FNDC3A JAK3 NF1 PPP5C MTHFR SUPT6H	3.49e-05	195	144	8	4318_UP
Drug	0198306-0000 [212631-61-3]; Down 200; 10uM; MCF7; HT_HG-U133A	CYP1A2 MUC5B STAT1 JAK3 EGR3 AP1G2 TIMELESS PARP12	3.49e-05	195	144	8	7099_DN
Drug	Enalapril maleate [76095-16-4]; Down 200; 8.2uM; PC3; HT_HG-U133A	COL6A1 MYO19 ZNF230 DENND3 STAT1 PPP5C ANAPC2 HMGXB3	3.62e-05	196	144	8	7265_DN
Drug	Gabexate mesilate [56974-61-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	CYP1A2 MTMR1 FNDC3A LCP1 STAT1 MBTPS2 PPP5C PARP12	3.62e-05	196	144	8	7357_DN
Drug	Fenspiride hydrochloride [5053-08-7]; Down 200; 13.4uM; PC3; HT_HG-U133A	USP34 ZNF93 COL6A1 ARFGEF2 STAT1 NF1 SMG7 CST6	3.62e-05	196	144	8	7298_DN
Drug	Stachydrine hydrochloride; Down 200; 22.2uM; PC3; HT_HG-U133A	CYP1A2 ABCA2 SYNE1 CHD7 DENND3 NEDD4 SUPT6H MTMR9	3.62e-05	196	144	8	4469_DN
Drug	Crotamiton [483-63-6]; Up 200; 19.6uM; MCF7; HT_HG-U133A	SLAMF8 COL6A1 XCR1 MUC5B NF1 EGR3 SLITRK5 IL2RB	3.76e-05	197	144	8	3388_UP
Drug	zinc protoporphyrin	USP34 CYP1A2 IRAK1 CHD7 STAT1 GUCY1A1 NOS2	3.90e-05	145	144	7	ctd:C017803
Drug	1 1S	HTR6 F10	3.97e-05	2	144	2	CID000087110
Drug	AC1NSWD2	SYNE1 TOP2B	3.97e-05	2	144	2	CID005318091
Drug	Metixene hydrochloride [1553-34-0]; Down 200; 11.6uM; PC3; HT_HG-U133A	USP34 TMC7 TARS2 NF1 PPP5C MTHFR SLITRK5 PLCG1	4.04e-05	199	144	8	6672_DN
Drug	AH6809; Down 200; 1uM; PC3; HT_HG-U133A	TMC7 TEP1 DENND3 STAT1 RAD50 NF1 MBTPS2 AP1G2	4.04e-05	199	144	8	7075_DN
Drug	quinoline	CYP1A2 ABCC1 ABCC4 MCHR1 SYNE1	4.22e-05	61	144	5	CID000007047
Disease	Bipolar Disorder	MCHR1 SYNE1 PDYN ERVW-1 NEDD4 EGR3 MTHFR TIMELESS GPRC5D PLCG1 CSMD1 IL2RB	5.19e-06	477	147	12	C0005586
Disease	Malignant neoplasm of breast	ABCC1 KLK10 MAN2C1 SYNE1 CD109 ARFGEF2 STAT1 NEDD4 HOOK3 NF1 MTHFR ITSN2 CST6 UTP20 TIMELESS CLUL1 NOS2 PGBD3	7.09e-06	1074	147	18	C0006142
Disease	centronuclear myopathy X-linked (implicated_via_orthology)	MTMR1 MTMR4 MTMR9	9.95e-06	9	147	3	DOID:0111225 (implicated_via_orthology)
Disease	Undifferentiated carcinoma of ovary	ALPK2 EPHB1	2.47e-05	2	147	2	C0346167
Disease	uterine fibroid	SYNE1 CD109 FNDC3A MTMR4 HOOK3 GUCY1A1 CSMD1	6.56e-05	199	147	7	EFO_0000731
Disease	Colorectal Neoplasms	CYP1A2 ABCC1 ABCC4 SYNE1 CD109 MTHFR TP63 ZNF292	7.88e-05	277	147	8	C0009404
Disease	anorectal malformation	MUC5B CSMD2 THBS2	1.11e-04	19	147	3	MONDO_0019938
Disease	transitional cell carcinoma (is_implicated_in)	RAD50 MTHFR TP63	1.74e-04	22	147	3	DOID:2671 (is_implicated_in)
Disease	Colorectal Carcinoma	CYP1A2 ABCC1 ABCC4 SYNE1 CD109 ZNF217 CSMD3 GFI1B NF1 MTHFR TP63 ZNF292	2.16e-04	702	147	12	C0009402
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	MTMR1 MTMR4 MTMR9	2.27e-04	24	147	3	DOID:10595 (implicated_via_orthology)
Disease	Anoxic-Ischemic Encephalopathy	IRAK1 NOS2	2.44e-04	5	147	2	C0752305
Disease	Hypoxic-Ischemic Encephalopathy	IRAK1 NOS2	2.44e-04	5	147	2	C0752304
Disease	Anoxia-Ischemia, Cerebral	IRAK1 NOS2	2.44e-04	5	147	2	C0752307
Disease	Anoxia-Ischemia, Brain	IRAK1 NOS2	2.44e-04	5	147	2	C0752306
Disease	Hypoxia-Ischemia, Brain	IRAK1 NOS2	2.44e-04	5	147	2	C0752308
Disease	Cerebral Hypoxia-Ischemia	IRAK1 NOS2	2.44e-04	5	147	2	C0178540
Disease	psychosis predisposition measurement	ABCC1 TMC7 CSMD1	2.90e-04	26	147	3	EFO_0008337
Disease	Mental Depression	MCHR1 PDYN CSMD2 EGR3 MTHFR TIMELESS NOS2	2.95e-04	254	147	7	C0011570
Disease	Mammary Carcinoma, Human	ABCC1 KLK10 MAN2C1 SYNE1 CD109 MTHFR ITSN2 CST6 CLUL1 NOS2	3.15e-04	525	147	10	C4704874
Disease	Mammary Neoplasms, Human	ABCC1 KLK10 MAN2C1 SYNE1 CD109 MTHFR ITSN2 CST6 CLUL1 NOS2	3.15e-04	525	147	10	C1257931
Disease	Mammary Neoplasms	ABCC1 KLK10 MAN2C1 SYNE1 CD109 MTHFR ITSN2 CST6 CLUL1 NOS2	3.25e-04	527	147	10	C1458155
Disease	pappalysin-1 measurement	USP34 CHD7	3.65e-04	6	147	2	EFO_0802845
Disease	Lung Neoplasms	MPP1 CYP1A2 COL6A1 TEP1 MTHFR TP63 NOS2	3.81e-04	265	147	7	C0024121
Disease	Breast Carcinoma	ABCC1 KLK10 MAN2C1 SYNE1 CD109 MTHFR ITSN2 CST6 CLUL1 NOS2	3.82e-04	538	147	10	C0678222
Disease	Malignant neoplasm of lung	MPP1 CYP1A2 COL6A1 TEP1 MTHFR TP63 NOS2	3.90e-04	266	147	7	C0242379
Disease	mood instability measurement	MMS22L EYS CSMD1 CMTR2 EPHB1	4.64e-04	128	147	5	EFO_0008475
Disease	juvenile myelomonocytic leukemia (is_implicated_in)	JAK3 NF1	5.09e-04	7	147	2	DOID:0050458 (is_implicated_in)
Disease	Depressive disorder	MCHR1 PDYN CSMD2 EGR3 MTHFR TIMELESS NOS2	6.38e-04	289	147	7	C0011581
Disease	primary ovarian insufficiency (is_implicated_in)	FANCA TP63	6.77e-04	8	147	2	DOID:5426 (is_implicated_in)
Disease	otosclerosis	MAN2C1 CD109 EGR3 ANAPC1	7.31e-04	81	147	4	EFO_0004213
Disease	Drug toxicity	CYP1A2 ABCC1 ABCC4 MTHFR	8.38e-04	84	147	4	C0013221
Disease	Adverse reaction to drug	CYP1A2 ABCC1 ABCC4 MTHFR	8.38e-04	84	147	4	C0041755
Disease	advanced glycation end-product measurement	CYP1A2 FANCA	8.67e-04	9	147	2	EFO_0007819
Disease	aplastic anemia (is_marker_for)	GFI1B ANAPC2	8.67e-04	9	147	2	DOID:12449 (is_marker_for)
Disease	lymphocyte count	TNPO1 ABCC1 MMS22L PCDHGB2 IRAK1 BEND3 CHD7 ZNF217 ERVW-1 LCP1 DENND3 FOCAD PPP5C GUCY1A1 ANAPC1 PARP12 SPIC	1.03e-03	1464	147	17	EFO_0004587
Disease	triacylglycerol 54:1 measurement	IGF2R ZFHX4	1.08e-03	10	147	2	EFO_0010419
Disease	Malignant tumor of colon	LRG1 GUCY1A1 MTHFR TP63 NOS2	1.23e-03	159	147	5	C0007102
Disease	coagulation factor XA measurement	ABCC1 F10	1.32e-03	11	147	2	EFO_0020266
Disease	eosinophil percentage of leukocytes	BEND3 CHD7 LCP1 RAD50 GFI1B PPP5C ANAPC1 ANAPC2 IL2RB ALPK2 ZNF292	1.33e-03	746	147	11	EFO_0007991
Disease	sunburn	MMS22L FANCA NTM TP63	1.38e-03	96	147	4	EFO_0003958
Disease	Mood Disorders	MCHR1 HTR6 PDYN MTHFR TIMELESS	1.57e-03	168	147	5	C0525045
Disease	homocysteine measurement	FANCA MTHFR CSMD1	1.57e-03	46	147	3	EFO_0004578
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 HOOK3	1.57e-03	12	147	2	DOID:11726 (implicated_via_orthology)
Disease	Rheumatoid Arthritis	ABCC4 IRAK1 STAT1 MTHFR IL2RB	1.83e-03	174	147	5	C0003873
Disease	liver cirrhosis (implicated_via_orthology)	RAD50 FOCAD	1.85e-03	13	147	2	DOID:5082 (implicated_via_orthology)
Disease	coagulation factor X measurement	ABCC1 F10	1.85e-03	13	147	2	EFO_0020265
Disease	ocular hypertension, response to triamcinolone acetonide	GCFC2 ZNF217 TIMELESS	1.89e-03	49	147	3	EFO_0006954, EFO_1001069
Disease	acute myeloid leukemia (is_marker_for)	GFI1B NF1 ANAPC2	1.89e-03	49	147	3	DOID:9119 (is_marker_for)
Disease	nephroblastoma (is_implicated_in)	IGF2R MTHFR	2.16e-03	14	147	2	DOID:2154 (is_implicated_in)
Disease	hepatocellular carcinoma (is_implicated_in)	TEP1 IGF2R MTHFR ARID2 PLCG1	2.18e-03	181	147	5	DOID:684 (is_implicated_in)
Disease	infant head circumference	ARFGEF2 PLCG1	2.48e-03	15	147	2	EFO_0004577
Disease	factor VII measurement	F10 NEDD4 FOCAD	2.63e-03	55	147	3	EFO_0004619
Disease	Drug habituation	ABCC4 SYNE1 CSMD3 CSMD1	2.66e-03	115	147	4	C0013170
Disease	Drug abuse	ABCC4 SYNE1 CSMD3 CSMD1	2.66e-03	115	147	4	C0013146
Disease	Prescription Drug Abuse	ABCC4 SYNE1 CSMD3 CSMD1	2.66e-03	115	147	4	C4316881
Disease	Substance-Related Disorders	ABCC4 SYNE1 CSMD3 CSMD1	2.66e-03	115	147	4	C0236969
Disease	Drug Use Disorders	ABCC4 SYNE1 CSMD3 CSMD1	2.66e-03	115	147	4	C0013222
Disease	Drug Dependence	ABCC4 SYNE1 CSMD3 CSMD1	2.66e-03	115	147	4	C1510472
Disease	Substance Dependence	ABCC4 SYNE1 CSMD3 CSMD1	2.66e-03	115	147	4	C0038580
Disease	Substance Use Disorders	ABCC4 SYNE1 CSMD3 CSMD1	2.66e-03	115	147	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	ABCC4 SYNE1 CSMD3 CSMD1	2.66e-03	115	147	4	C0029231
Disease	Substance abuse problem	ABCC4 SYNE1 CSMD3 CSMD1	2.75e-03	116	147	4	C0740858
Disease	isoleucine measurement	TNPO1 LCP1 NTM	2.77e-03	56	147	3	EFO_0009793
Disease	Cardiovascular Abnormalities	NOS2 ZNF292	2.83e-03	16	147	2	C0243050
Disease	Diabetic Angiopathies	THBS2 MTHFR	2.83e-03	16	147	2	C0011875
Disease	Microangiopathy, Diabetic	THBS2 MTHFR	2.83e-03	16	147	2	C0025945
Disease	non-high density lipoprotein cholesterol measurement	TNPO1 USP34 ARFGEF2 CHD7 LCP1 IGF2R PPP5C ITSN2 OSBPL9 HYDIN	3.13e-03	713	147	10	EFO_0005689
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	CYP1A2 JAK3 MTHFR	3.53e-03	61	147	3	C1961102
Disease	cortical thickness change measurement	EGR3 CSMD1	3.58e-03	18	147	2	EFO_0021501
Disease	squamous cell carcinoma (is_implicated_in)	IRAK1 MTHFR	3.58e-03	18	147	2	DOID:1749 (is_implicated_in)
Disease	Prostatic Neoplasms	ABCC4 USP28 CHD7 IGF2R MTHFR ARID2 ITSN2 CST6 ZNF292	3.84e-03	616	147	9	C0033578
Disease	Malignant neoplasm of prostate	ABCC4 USP28 CHD7 IGF2R MTHFR ARID2 ITSN2 CST6 ZNF292	3.84e-03	616	147	9	C0376358
Disease	ankylosing spondylitis (is_implicated_in)	IRAK1 MTHFR	3.99e-03	19	147	2	DOID:7147 (is_implicated_in)
Disease	Pseudopelade	MBTPS2 MTHFR	3.99e-03	19	147	2	C0086873
Disease	Omenn Syndrome	CHD7 JAK3	3.99e-03	19	147	2	C2700553
Disease	Juvenile Myelomonocytic Leukemia	JAK3 NF1	3.99e-03	19	147	2	C0349639
Disease	cholangiocarcinoma (is_marker_for)	MFSD4A MUC5B NOS2	4.04e-03	64	147	3	DOID:4947 (is_marker_for)
Disease	corneal hysteresis	COL6A1 ANAPC1	4.42e-03	20	147	2	EFO_0010066
Disease	interstitial lung disease	MUC5B NTM CSMD1	4.60e-03	67	147	3	EFO_0004244
Disease	Schizophrenia	CYP1A2 MCHR1 HTR6 PDYN ERVW-1 CSMD2 PNPO EGR3 MTHFR CSMD1 MCTP2	4.81e-03	883	147	11	C0036341
Disease	haptoglobin measurement	CMTR2 HYDIN	4.86e-03	21	147	2	EFO_0004640

Protein segments in the cluster

Peptide	Gene	Start	Entry
WLPFFVANIVQAVCD	HTR6	281	P50406
PFCVLFTENNGRWIE	CPNE2	46	Q96FN4
ISGNPWICDQNLSDL	LRG1	296	P02750
NISPEFWNAISQCEN	ANAPC2	86	Q9UJX6
CQSVPNALAQWNDTI	CSMD1	1781	Q96PZ7
NALAQWNDTIPSCVV	CSMD1	1786	Q96PZ7
DNNAHCVWIITALNP	CSMD2	426	Q7Z408
ENNQWSANIPICIFP	CSMD3	706	Q7Z407
WLLCFVSQGQNQDVI	B3GALT5-AS1	61	P59052
WEKPTTLTANNECFQ	ALPK2	986	Q86TB3
NEVLLSDVFAQLQWC	ARFGEF2	1421	Q9Y6D5
QWLNAHFEVNPDCSV	ARID2	526	Q68CP9
EDISQQPLVQVAAWC	AP1G2	466	O75843
NNEWQLPDPSEIFTC	CMTR2	41	Q8IYT2
QEDFCNNLVNSLPLW	CD177	106	Q8N6Q3
DLVQAFPWQCVLVAE	DNHD1	1501	Q96M86
FQLLPEEEQLWAACA	DENND3	1081	A2RUS2
CIIFDSDWNPQNDLQ	CHD7	1381	Q9P2D1
VVQDADWLASCNPDA	CHD7	1706	Q9P2D1
DIECQAESFPNWTLA	MUC5B	1546	Q9HC84
DRSPIFLQFVDCVWQ	MTMR1	496	Q13613
LHVANVIDFSPEQCW	RBM41	251	Q96IZ5
LNNVIFCHQEDSNWP	RAD50	151	Q92878
CVFVNQWQVNHDPEL	CYP1A2	406	P05177
DSDPSQQWCADLQTL	ITSN2	1186	Q9NZM3
WTQGEQEVLQPFCDF	JAK3	281	P52333
HLEDTAWTPCVNNLN	KCNJ9	91	Q92806
IFQCHWTLPNDTEEN	OSBPL9	461	Q96SU4
NSPQDLETQLWACAF	LRWD1	286	Q9UFC0
FFDIWICANNPNRLE	MORC1	506	Q86VD1
TAVWQAECLPQLNDF	BEND3	321	Q5T5X7
AFTVDSPVQQALWCD	ANAPC1	116	Q9H1A4
SPVQQALWCDFIISQ	ANAPC1	121	Q9H1A4
PANVEFTQLCIDLGW	NOS2	281	P35228
QDDKNQSLFCWEIPV	NPC2	131	P61916
CNVFEPNQNNWLLTT	EPHB1	61	P54762
FSNPCILWLHADQAV	TRIT1	221	Q9H3H1
LVDNDFPLDNCLWQV	MTHFR	621	P42898
FPLDNCLWQVVEDTL	MTHFR	626	P42898
QTAQDWPATSLNCIA	PTCD3	566	Q96EY7
TLCKSANPQWQEQFD	MCTP2	391	Q6DN12
SINCLNEEWCFNIIG	EYS	416	Q5T1H1
WVVLDQPDAACHLQQ	NEDD4	591	P46934
PQISWVFFSQQLCLL	MFSD4A	51	Q8N468
LQCEASAVPSAEFQW	NTM	241	Q9P121
LDCVWQILRQFPCSF	MTMR9	401	Q96QG7
LFLDCVWQLLQQFPA	MTMR11	436	A4FU01
WSFINYQDNQPCLDL	MYO19	461	Q96H55
QLFGWDDIICPQVVA	MMS22L	771	Q6ZRQ5
LSTLFPNQCLDWTNL	GFI1B	46	Q5VTD9
QNSLAGPQECWLLTA	HMGXB3	761	Q12766
FVNWINKALENDPDC	LCP1	126	P13796
PAQDLVCDNASWEQN	PCDHGB2	776	Q9Y5G2
FWGQDINNLTTPLEC	PDPR	721	Q8NCN5
AAQCLAHPWLNNLAE	MYLK2	531	Q9H1R3
SLQCQAALLPSEEWE	PDYN	46	P01213
CQLFLEPQLWSQLAD	NAT16	331	Q8N8M0
EPQLWSQLADFCQVG	NAT16	336	Q8N8M0
NLPADLDLVCNAEWV	NAGS	311	Q8N159
QFAAWFEEAVQCPDI	PNPO	61	Q9NVS9
QDLCQLVNADAPYWL	MON2	221	Q7Z3U7
LLTWIQTFNVDAPCQ	HOOK3	16	Q86VS8
ALEPADWCQFAALIV	IRAK1	36	P51617
AVSVEQCLAALFPAW	MRGPRE	116	Q86SM8
EDQNEQCPVFLQWLD	MTMR4	461	Q9NYA4
LEQQVCTLNWDVGFV	NUP155	1271	O75694
SYNELCQLLFQNDPW	PARP12	136	Q9H0J9
NPLQDANLCSRVFFW	ABCC4	11	O15439
EQFWEACAELQQPAL	PCTP	11	Q9UKL6
QHIWDFLEQPICSVQ	TP63	56	Q9H3D4
AVFQECGLWVLTDAN	CD109	631	Q6YHK3
FCWISEEIESLQNPA	HYDIN	4011	Q4G0P3
LLQACWTAAQDEPET	COL6A1	11	P12109
QVAACLPEKWFENSA	GCFC2	701	P16383
QWDDPVVCIALVTNA	GPRC5D	236	Q9NZD1
SATCAQVNWEVPLSN	FNDC3A	771	Q9Y2H6
FDSPSNWCQDNIISL	EGR3	91	Q06889
LVVCFPEAQQLLEDW	FANCA	396	O15360
NQTCELLPVSQASWA	IL2RB	71	P14784
QLDTIDNAACGWIQF	ABCA2	556	Q9BZC7
IVGLQWPEDTDCSQF	CORIN	546	Q9Y5Q5
LLWEDFTNCNPTIDL	IFFO2	391	Q5TF58
PEFIFACSQAQQLEW	MAN2C1	291	Q9NTJ4
PVTNVQDWNECLDTI	MBTPS2	286	O43462
AIVNAVPCFALDGQW	MBTPS2	456	O43462
HWCNNVPDIFIINLS	MCHR1	141	Q99705
CDFEVLVVPWQNSSQ	CST6	126	Q15828
LQEAFDQACSSPQWV	MPP1	446	Q00013
CPWQALLINEENEGF	F10	246	P00742
QTDLLALSQADPQCW	FAM237A	36	A0A1B0GTK4
LGNEHCDNEWINPFL	RXYLT1	201	Q9Y2B1
FSSWVQLEVPLQDCE	IPO13	226	O94829
DCWPVFLQQLTAFFQ	FOCAD	146	Q5VW36
PLLFCFELVLQNAWQ	PGBD3	486	Q8N328
NPDFTKCFQNTVLVW	ABCC1	26	P33527
VVSFLWNTEAACPIQ	IGF2R	911	P11717
AQPLCEELCQAWFAN	RTBDN	111	Q9BSG5
FLGDPCLWDQAEQVL	TARS2	501	Q9BW92
FASCQPEELIQKWNT	UTP20	2491	O75691
TQCQAWEELEDQLPN	SUSD2	291	Q9UGT4
HEVSAQNPTNCWICL	ERVW-1	176	Q9UQF0
LNWQDIPFLVQCSEC	TRIM49	41	P0CI25
GRWQEPFQLCQFEVT	PUS3	256	Q9BZE2
DLQNPIIVQLCDQWD	SMCHD1	1276	A6NHR9
PPNACLDQLQNWFTI	STAT1	251	P42224
SWELAPAQAVQLDCQ	SSPOP	4736	A2VEC9
IWVFINCLIENPTFD	TOP2B	381	Q02880
QQCQAWLSAVQPDLE	SYNE1	4046	Q8NF91
CLLFWPENQELDQDS	SAMD9L	1431	Q8IVG5
CSQNPTEAIEAWINF	KBTBD4	201	Q9NVX7
FSEVFEWLPLAQCIN	PPP5C	331	P53041
SQDEQLCWTQLLALF	SMG7	321	Q92540
EVNCNWTLPVLAEFT	PRAMEF20	211	Q5VT98
FIQIDLQENPWDCTC	SLITRK2	521	Q9H156
FQACNEFSECLVNPW	IMPG2	1016	Q9BZV3
CVQPDQEYLSLNNWN	SPIC	216	Q8N5J4
EEDQFSQNPISCFEW	TM4SF20	36	Q53R12
FQHWDPDILCLQEVQ	ANGEL1	286	Q9UNK9
DLEQCWDIPNFFQLF	CLUL1	241	Q15846
CFLNSAVQVLWQLDI	USP53	41	Q70EK8
CQQDNFPELSEVWNH	SUPT6H	1201	Q7KZ85
DLQSQPCENQAWVFA	XCR1	16	P46094
VEAVWPALAEQLQCC	TIMELESS	556	Q9UNS1
LEEWECLNPAQQNLY	ZNF431	46	Q8TF32
VICSHFAQDLWPEQN	ZNF93	76	P35789
DQCTVAFPTLELWQE	ZFHX4	2451	Q86UP3
INFTCEEWALLGPSQ	ZNF441	11	Q8N8Z8
PNDWNLNIYFNCTDL	TSPAN17	161	Q96FV3
FCAIVQLPSDWIQVA	TEP1	326	Q99973
QLEENPWNCSCELIS	SLITRK5	231	O94991
FADWLPNNVKTAVCD	TUBB8	341	Q3ZCM7
CQELLNFFIWIPDAT	SAGE2P	416	A6NJ88
PFNDVCQWFIDRADL	SRL	206	Q86TD4
LNWQDIPFLVQCSEC	TRIM49C	41	P0CI26
FGDQINNDNCWDPIL	SEPTIN12	116	Q8IYM1
CLPVELSDKQWEQFQ	ZNF292	116	O60281
ALANVVPCSQWDELA	NF1	1226	P21359
ENSVWNSQLDAVCPD	PLCG1	306	P19174
QQDQLLAICNADLGW	TIGIT	61	Q495A1
CQVFLSCWAPNISEI	SLAMF8	146	Q9P0V8
CWFSAVIQSLFQLPE	USP28	171	Q96RU2
SFQVLGPVCWQQLDL	PIGZ	16	Q86VD9
NPEFISVCNNATWAI	TNPO1	726	Q92973
EFSPEEWQCLDTAQQ	ZNF91	21	Q05481
QLSPNLWVDAQSTCE	WFIKKN1	36	Q96NZ8
LNWQDIPILTQCFEC	TRIM49D1	41	C9J1S8
PCQQIWEQTASDLTQ	ZNF230	91	Q9UIE0
CIPQLDPFTTFQAWQ	ZNF217	286	O75362
EYNPSQCLDWLAVQT	USP34	2636	Q70CQ2
DLDGWPNLNLVCATN	THBS2	696	P35442
VCSHFAQDLWPEQSI	ZNF486	86	Q96H40
QCWGQQEFAIPDNVL	TMC7	531	Q7Z402
SIFPCEVAQQLWQGQ	GUCY1A1	456	Q02108
AQLWAAEAALLPQND	KLK10	26	O43240