Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	NADH oxidase H202-forming activity	DUOX1 DUOX2	6.91e-06	2	53	2	GO:0106293
GeneOntologyMolecularFunction	NADPH oxidase H202-forming activity	DUOX1 DUOX2	6.88e-05	5	53	2	GO:0106294
GeneOntologyMolecularFunction	NAD(P)H oxidase H2O2-forming activity	DUOX1 DUOX2	4.49e-04	12	53	2	GO:0016174
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	DUOX1 DUOX2	4.49e-04	12	53	2	GO:0016175
GeneOntologyMolecularFunction	heme binding	DUOX1 CYP11B2 CYP17A1 DUOX2	7.43e-04	154	53	4	GO:0020037
GeneOntologyMolecularFunction	tetrapyrrole binding	DUOX1 CYP11B2 CYP17A1 DUOX2	9.39e-04	164	53	4	GO:0046906
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	DUOX1 DUOX2	1.27e-03	20	53	2	GO:0050664
GeneOntologyBiologicalProcess	cuticle development	DUOX1 DUOX2	1.94e-05	3	53	2	GO:0042335
GeneOntologyBiologicalProcess	hormone biosynthetic process	DUOX1 CYP11B2 CYP17A1 DUOX2	6.14e-05	83	53	4	GO:0042446
HumanPheno	Increased circulating corticosterone level	CYP11B2 CYP17A1	2.10e-05	3	14	2	HP:0032362
HumanPheno	Abnormal circulating corticosterone level	CYP11B2 CYP17A1	4.20e-05	4	14	2	HP:0012112
HumanPheno	Abnormal circulating renin concentration	CYP11B2 CYP17A1 INSR	8.59e-05	33	14	3	HP:0040084
Domain	DUOX1	DUOX1 DUOX2	7.90e-06	2	53	2	IPR029595
Domain	NAD_binding_6	DUOX1 DUOX2	1.64e-04	7	53	2	PF08030
Domain	FAD-bd_8	DUOX1 DUOX2	1.64e-04	7	53	2	IPR013112
Domain	Fe_red_NAD-bd_6	DUOX1 DUOX2	1.64e-04	7	53	2	IPR013121
Domain	FAD_binding_8	DUOX1 DUOX2	1.64e-04	7	53	2	PF08022
Domain	DUF4939	RTL6 RTL3	3.50e-04	10	53	2	PF16297
Domain	Haem_peroxidase	DUOX1 DUOX2	3.50e-04	10	53	2	IPR010255
Domain	An_peroxidase	DUOX1 DUOX2	3.50e-04	10	53	2	PF03098
Domain	PEROXIDASE_3	DUOX1 DUOX2	3.50e-04	10	53	2	PS50292
Domain	DUF4939	RTL6 RTL3	3.50e-04	10	53	2	IPR032549
Domain	-	DUOX1 DUOX2	3.50e-04	10	53	2	1.10.640.10
Domain	Haem_peroxidase_animal	DUOX1 DUOX2	3.50e-04	10	53	2	IPR019791
Domain	LDOC1-rel	RTL6 RTL3	4.27e-04	11	53	2	IPR032567
Domain	Fe3_Rdtase_TM_dom	DUOX1 DUOX2	5.12e-04	12	53	2	IPR013130
Domain	Ferric_reduct	DUOX1 DUOX2	5.12e-04	12	53	2	PF01794
Domain	Fd_Rdtase_FAD-bd	DUOX1 DUOX2	1.31e-03	19	53	2	IPR017927
Domain	FAD_FR	DUOX1 DUOX2	1.31e-03	19	53	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	DUOX1 DUOX2	1.31e-03	19	53	2	IPR017938
Domain	-	ZCCHC18 RTL3	2.46e-03	26	53	2	4.10.60.10
Domain	ZF_CCHC	ZCCHC18 RTL3	4.43e-03	35	53	2	PS50158
Domain	Cyt_P450_CS	CYP11B2 CYP17A1	9.93e-03	53	53	2	IPR017972
Domain	ZnF_C2HC	ZCCHC18 RTL3	1.07e-02	55	53	2	SM00343
Domain	Znf_CCHC	ZCCHC18 RTL3	1.07e-02	55	53	2	IPR001878
Domain	fn3	SNED1 INSR EGFLAM	1.09e-02	162	53	3	PF00041
Domain	SCAN	ZNF500 ZNF445	1.10e-02	56	53	2	SM00431
Domain	CYTOCHROME_P450	CYP11B2 CYP17A1	1.14e-02	57	53	2	PS00086
Domain	SCAN_BOX	ZNF500 ZNF445	1.18e-02	58	53	2	PS50804
Domain	-	CYP11B2 CYP17A1	1.18e-02	58	53	2	1.10.630.10
Domain	SCAN	ZNF500 ZNF445	1.18e-02	58	53	2	PF02023
Domain	p450	CYP11B2 CYP17A1	1.18e-02	58	53	2	PF00067
Domain	SCAN_dom	ZNF500 ZNF445	1.18e-02	58	53	2	IPR003309
Domain	Retrov_capsid_C	ZNF500 ZNF445	1.22e-02	59	53	2	IPR008916
Domain	Cyt_P450	CYP11B2 CYP17A1	1.26e-02	60	53	2	IPR001128
Pathway	KEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE	CYP11B2 CYP17A1	6.67e-05	5	37	2	M47522
Pathway	REACTOME_THYROXINE_BIOSYNTHESIS	DUOX1 DUOX2	2.39e-04	9	37	2	MM14833
Pathway	WP_15Q112_COPY_NUMBER_VARIATION_SYNDROME	CYFIP1 TUBGCP5	2.39e-04	9	37	2	M39879
Pathway	REACTOME_THYROXINE_BIOSYNTHESIS	DUOX1 DUOX2	2.98e-04	10	37	2	M27120
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B2 CYP17A1	2.98e-04	10	37	2	M27076
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B2 CYP17A1	3.63e-04	11	37	2	MM14750
Pubmed	Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.	DUOX1 DUOX2	2.37e-06	2	54	2	28633507
Pubmed	Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.	DUOX1 DUOX2	2.37e-06	2	54	2	15972824
Pubmed	Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families.	DUOX1 DUOX2	2.37e-06	2	54	2	30375286
Pubmed	The extracellular A-loop of dual oxidases affects the specificity of reactive oxygen species release.	DUOX1 DUOX2	2.37e-06	2	54	2	25586178
Pubmed	Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins.	DUOX1 DUOX2	2.37e-06	2	54	2	23362256
Pubmed	Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.	DUOX1 DUOX2	2.37e-06	2	54	2	19144650
Pubmed	Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.	DUOX1 DUOX2	2.37e-06	2	54	2	10806195
Pubmed	Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.	DUOX1 DUOX2	2.37e-06	2	54	2	11514595
Pubmed	Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.	DUOX1 DUOX2	2.37e-06	2	54	2	16111680
Pubmed	Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling.	DUOX1 DUOX2	2.37e-06	2	54	2	24161126
Pubmed	Reactive oxygen species regulate the levels of dual oxidase (Duox1-2) in human neuroblastoma cells.	DUOX1 DUOX2	2.37e-06	2	54	2	22523549
Pubmed	Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas.	DUOX1 DUOX2	2.37e-06	2	54	2	11762710
Pubmed	Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.	DUOX1 DUOX2	2.37e-06	2	54	2	11822874
Pubmed	Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases.	DUOX1 DUOX2	2.37e-06	2	54	2	11753072
Pubmed	Expression of dual oxidases and secreted cytokines in chronic rhinosinusitis.	DUOX1 DUOX2	2.37e-06	2	54	2	23281318
Pubmed	Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.	DUOX1 DUOX2	2.37e-06	2	54	2	18281478
Pubmed	Structural and functional characterization of the two human ThOX/Duox genes and their 5'-flanking regions.	DUOX1 DUOX2	2.37e-06	2	54	2	15062544
Pubmed	Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response.	DUOX1 DUOX2	2.37e-06	2	54	2	31706280
Pubmed	Regulated hydrogen peroxide production by Duox in human airway epithelial cells.	DUOX1 DUOX2	2.37e-06	2	54	2	15677770
Pubmed	Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues.	DUOX1 DUOX2	2.37e-06	2	54	2	11443211
Pubmed	Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.	DUOX1 DUOX2	2.37e-06	2	54	2	10601291
Pubmed	Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease.	DUOX1 DUOX2	2.37e-06	2	54	2	18177232
Pubmed	Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection.	DUOX1 DUOX2	2.37e-06	2	54	2	24128054
Pubmed	Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.	DUOX1 DUOX2	2.37e-06	2	54	2	12824283
Pubmed	NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.	DUOX1 DUOX2	7.09e-06	3	54	2	21915726
Pubmed	NADPH oxidase-dependent acid production in airway epithelial cells.	DUOX1 DUOX2	7.09e-06	3	54	2	15210697
Pubmed	Characterization of steroidogenic enzyme expression in aldosterone-producing adenoma: a comparison with various human adrenal tumors.	CYP11B2 CYP17A1	7.09e-06	3	54	2	23257735
Pubmed	Role of nicotinamide adenine dinucleotide phosphate oxidase in mediating vesicant-induced interleukin-6 secretion in human airway epithelial cells.	DUOX1 DUOX2	7.09e-06	3	54	2	24164541
Pubmed	DUOX enzyme activity promotes AKT signalling in prostate cancer cells.	DUOX1 DUOX2	7.09e-06	3	54	2	23225414
Pubmed	Association of duoxes with thyroid peroxidase and its regulation in thyrocytes.	DUOX1 DUOX2	7.09e-06	3	54	2	19952225
Pubmed	Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.	DUOX1 DUOX2	1.42e-05	4	54	2	27110716
Pubmed	Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome.	CYFIP1 TUBGCP5	1.42e-05	4	54	2	16982806
Pubmed	The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA.	DUOX1 DUOX2	1.42e-05	4	54	2	22814254
Pubmed	Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus.	CYP17A1 INSR	1.42e-05	4	54	2	11232039
Pubmed	Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.	DUOX1 DUOX2	1.42e-05	4	54	2	19339556
Pubmed	Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.	CYFIP1 TUBGCP5	1.42e-05	4	54	2	14508708
Pubmed	Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1alpha/IFN-gamma, an effect partially mediated by nitric oxide.	DUOX1 DUOX2	2.36e-05	5	54	2	16478776
Pubmed	Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation.	DUOX1 DUOX2	2.36e-05	5	54	2	34784249
Pubmed	FOXL2 interaction with different binding partners regulates the dynamics of ovarian development.	CYP17A1 USP7	2.36e-05	5	54	2	38517962
Pubmed	Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.	DUOX1 DUOX2	2.36e-05	5	54	2	15561711
Pubmed	Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome.	CYP17A1 INSR	3.54e-05	6	54	2	19387820
Pubmed	Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis.	CYP11B2 CYP17A1	3.54e-05	6	54	2	17890294
Pubmed	Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta.	DUOX1 DUOX2	3.54e-05	6	54	2	12671064
Pubmed	Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult.	DUOX1 DUOX2	3.54e-05	6	54	2	17332529
Pubmed	APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury.	DUOX1 DUOX2	3.54e-05	6	54	2	28165467
Pubmed	Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine.	MYO6 MEOX2	4.94e-05	7	54	2	20351096
Pubmed	Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase.	DUOX1 DUOX2	4.94e-05	7	54	2	19005069
Pubmed	Structural and functional abnormalities in the spleen of an mFtz-F1 gene-disrupted mouse.	CYP11B2 CYP17A1	4.94e-05	7	54	2	10029587
Pubmed	Identification of a novel population of adrenal-like cells in the mammalian testis.	CYP11B2 CYP17A1	6.59e-05	8	54	2	16949566
Pubmed	Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production.	CYP11B2 CYP17A1	8.46e-05	9	54	2	12399432
Pubmed	Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo.	CYP11B2 CYP17A1	8.46e-05	9	54	2	7588219
Pubmed	Genetic polymorphisms and susceptibility to lung disease.	DUOX1 DUOX2	1.06e-04	10	54	2	16608528
Pubmed	A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes.	RTL6 RTL3	1.29e-04	11	54	2	16093683
Pubmed	Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO.	DUOX1 DUOX2	1.29e-04	11	54	2	30755476
Pubmed	Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals.	RTL6 RTL3	1.29e-04	11	54	2	15716091
Pubmed	VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.	MEOX2 TBX6	1.55e-04	12	54	2	18519639
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	PABPC3 TNRC6C	2.13e-04	14	54	2	19716330
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	TNRC6C ANKHD1 GARRE1	2.67e-04	80	54	3	35803934
Pubmed	Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure.	CYP11B2 CYP17A1	2.80e-04	16	54	2	37727456
Pubmed	Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals.	EVX1 MEOX2	2.80e-04	16	54	2	22219351
Pubmed	Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.	EVX1 TBX6	2.80e-04	16	54	2	12431380
Pubmed	Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation.	EVX1 TBX6	3.56e-04	18	54	2	17507393
Pubmed	Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors.	CYP11B2 CYP17A1	3.56e-04	18	54	2	25933105
Pubmed	Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice.	MEOX2 TBX6	3.56e-04	18	54	2	16801545
Pubmed	A quantitative survey of gravity receptor function in mutant mouse strains.	SPTBN4 MYO6	4.42e-04	20	54	2	16235133
Pubmed	BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites.	MEOX2 TBX6	4.42e-04	20	54	2	16943278
Pubmed	Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo.	EVX1 TBX6	4.88e-04	21	54	2	10421635
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	SPTBN4 ANKHD1	5.36e-04	22	54	2	12812986
Pubmed	A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.	EVX1 TBX6	5.36e-04	22	54	2	10021340
Pubmed	Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer.	CYP11B2 CYP17A1	5.86e-04	23	54	2	16638864
Pubmed	Fgfr2 is required for the expansion of the early adrenocortical primordium.	CYP11B2 INSR	6.39e-04	24	54	2	26141512
Pubmed	Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.	DUOX1 DUOX2	7.51e-04	26	54	2	33905568
Pubmed	Family-based analysis of candidate genes for polycystic ovary syndrome.	CYP17A1 INSR	8.10e-04	27	54	2	20200332
Pubmed	Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes.	CYP11B2 CYP17A1	8.72e-04	28	54	2	25668066
Pubmed	Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo.	EVX1 TBX6	8.72e-04	28	54	2	16109169
Pubmed	Motor neuron position and topographic order imposed by β- and γ-catenin activities.	CDH20 EVX1	9.35e-04	29	54	2	22036570
Pubmed	A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation.	MEOX2 TBX6	1.00e-03	30	54	2	32597756
Pubmed	Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.	MYO6 MEOX2	1.00e-03	30	54	2	28077597
Pubmed	Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.	CYP11B2 CYP17A1	1.07e-03	31	54	2	15583024
Pubmed	Genome-wide association study identifies eight loci associated with blood pressure.	RTKN2 CYP17A1	1.14e-03	32	54	2	19430483
Pubmed	eXPRESSION: an in silico tool to predict patterns of gene expression.	ZCCHC18 FRRS1L	1.36e-03	35	54	2	15939374
Pubmed	A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.	CYP11B2 CYP17A1	1.52e-03	37	54	2	26108225
Cytoband	15q15.3	DUOX1 DUOX2	4.00e-04	25	54	2	15q15.3
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	ZCCHC18 RTL3	1.12e-03	25	36	2	74
GeneFamily	Fibronectin type III domain containing	SNED1 INSR EGFLAM	3.92e-03	160	36	3	555
GeneFamily	HOXL subclass homeoboxes	EVX1 MEOX2	4.80e-03	52	36	2	518
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SPTBN4 RTKN2 OSBPL7	7.89e-03	206	36	3	682
GeneFamily	EF-hand domain containing	CACNA1E DUOX1 DUOX2	9.33e-03	219	36	3	863
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Fibroblasts\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RTKN2 CYP17A1 PABPC3 GLIPR1L1 NEU3	8.44e-07	143	54	5	57ee1830d96d73d92b5f83b028592a5d952c6013
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Fibroblasts-Monocytes-Macrophages\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CYP17A1 PABPC3 GLIPR1L1 NEU3 MEOX2	1.10e-06	151	54	5	f13a117ae26ae525da4f3e837d8f204d00dc6ee3
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-24m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN4 ZCCHC18 CACNA1E CDH20 HLA-DMA	1.47e-06	160	54	5	6bafbe2b4b98bc088406a516d079093f89d9c344
Drug	pregnanetriol	MYO6 CYP11B2 CYP17A1 ACP2	1.46e-06	36	53	4	CID000101967
Drug	alpha-aminoisobutyric acid	CACNA1E INSR BTG3 TAFAZZIN	2.49e-06	41	53	4	CID000006119
Drug	androstane-3,17-dione	CYP17A1 INSR EVX1 MEOX2	6.03e-06	51	53	4	CID000000443
Disease	phenylketonuria (implicated_via_orthology)	DUOX1 DUOX2	1.62e-05	4	49	2	DOID:9281 (implicated_via_orthology)
Disease	Drug Use Disorders	RTL6 MYO6 INSR CTNNA3	4.05e-05	115	49	4	C0013222
Disease	Drug Dependence	RTL6 MYO6 INSR CTNNA3	4.05e-05	115	49	4	C1510472
Disease	Drug habituation	RTL6 MYO6 INSR CTNNA3	4.05e-05	115	49	4	C0013170
Disease	Substance Dependence	RTL6 MYO6 INSR CTNNA3	4.05e-05	115	49	4	C0038580
Disease	Substance Use Disorders	RTL6 MYO6 INSR CTNNA3	4.05e-05	115	49	4	C0038586
Disease	Substance-Related Disorders	RTL6 MYO6 INSR CTNNA3	4.05e-05	115	49	4	C0236969
Disease	Drug abuse	RTL6 MYO6 INSR CTNNA3	4.05e-05	115	49	4	C0013146
Disease	Organic Mental Disorders, Substance-Induced	RTL6 MYO6 INSR CTNNA3	4.05e-05	115	49	4	C0029231
Disease	Prescription Drug Abuse	RTL6 MYO6 INSR CTNNA3	4.05e-05	115	49	4	C4316881
Disease	Substance abuse problem	RTL6 MYO6 INSR CTNNA3	4.19e-05	116	49	4	C0740858
Disease	able to hear with hearing aids	AHRR MYO6	5.64e-05	7	49	2	EFO_0009720
Disease	primary bacterial infectious disease (implicated_via_orthology)	DUOX1 DUOX2	9.65e-05	9	49	2	DOID:0050338 (implicated_via_orthology)
Disease	hypothyroidism (implicated_via_orthology)	DUOX1 DUOX2	2.08e-04	13	49	2	DOID:1459 (implicated_via_orthology)
Disease	congenital hypothyroidism (implicated_via_orthology)	DUOX1 DUOX2	2.43e-04	14	49	2	DOID:0050328 (implicated_via_orthology)
Disease	pulse pressure measurement	SPTBN4 CYFIP1 CYP11B2 CYP17A1 INSR CTNNA3 OSBPL7 PPCS GARRE1	4.20e-04	1392	49	9	EFO_0005763
Disease	diabetes mellitus (is_implicated_in)	CYP11B2 INSR	1.07e-03	29	49	2	DOID:9351 (is_implicated_in)
Disease	mean arterial pressure	CYP11B2 CYP17A1 INSR USP7 PRSS42P	1.40e-03	499	49	5	EFO_0006340
Disease	unipolar depression, systolic blood pressure	CYP17A1 EVX1	1.46e-03	34	49	2	EFO_0003761, EFO_0006335

Protein segments in the cluster

Peptide	Gene	Start	Entry
HWAMDPPQVVFGQPP	AHRR	176	A9YTQ3
VRAMNSHGPSPRSWP	EGFLAM	216	Q63HQ2
IGSAPPLRHSWQMPN	CACNA1E	2266	Q15878
QRLAMTWPHPADPAF	EVX1	241	P49640
RMPNSPSADWPLQGV	CCSER1	596	Q9C0I3
NPLLMWAAPDPATGQ	DUOX1	211	Q9NRD9
DPIWRGPLPSNGVMH	CYFIP1	1106	Q7L576
QRAPHPPNMHVWGEA	KIAA0100	481	Q14667
MAPWSHPSAQLQPVG	LILRA5	1	A6NI73
MAAANPWDPASAPNG	HAUS2	1	Q9NVX0
QNPLLMWAAPDPATG	DUOX2	216	Q9NRD8
MWAAPDPATGQNGPR	DUOX2	221	Q9NRD8
MARHGPPWSRLDAQQ	TUBGCP5	1	Q96RT8
EMAQRGLPPAHDPWE	SLC9A3R2	106	Q15599
NWHLPQMSSPPSAAR	MEOX2	91	P50222
RSNDPKSQNHPGWLM	INSR	566	P06213
WTAQGARPHPFQNKP	PABPC3	431	Q9H361
HGLRLPPWASPQTMQ	ACP2	216	P11117
PQPPGAARWAEVMAR	PPCS	11	Q9HAB8
QSPAGPRHPVVMWRM	CTNNA3	836	Q9UI47
AAMWNPREAQAGAAP	CDH20	681	Q9HBT6
MARPPRQHPGVWASL	FRRS1L	1	Q9P0K9
WHQPDQFMPERFLNP	CYP17A1	406	P05093
GNPRGNWPPMDDAHR	GARRE1	871	O15063
LQRARWMPGSVPNHP	GCNT3	336	O95395
PTPMWPDDLQNHTFL	HLA-DMA	31	P28067
WEGTDSQQPHPRMKP	MAMSTR	131	Q6ZN01
HNEWRGKVNPPAADM	GLIPR1L1	41	Q6UWM5
LPFEAMPQHPGNRWL	CYP11B2	36	P19099
PGHPRMEELNEWPQN	KLHL30-AS1	51	Q8NEE0
MAPGQAPHQATPWRD	PPP1R15A	1	O75807
WKPNSMPPDHERNFG	OSBPL7	721	Q9BZF2
LPPPWATLFDGNHQM	RTKN2	466	Q8IZC4
EHMNPPAAWEAQKTP	RTL3	66	Q8N8U3
WAIPHMQPDSPLRNN	RTL6	151	Q6ICC9
NPNANPAAWPVLGHE	TNRC6C	101	Q9HCJ0
RLPQWTHPNSMDNLP	TNRC6C	1296	Q9HCJ0
TPPNMPAAWGHASFI	TMEM131L	1501	A2VDJ0
PAAQAWGPALAMPQA	SPATA25	56	Q9BR10
WNPPNGPAARQMLDG	SNED1	926	Q8TER0
VPPPGMHCDRNHWIN	BTG3	231	Q14201
NGLHNPDPAWNPMIK	ANKHD1	2496	Q8IWZ3
HGANWVRPNLSIMPP	C11orf42	221	Q8N5U0
LPGHRTMNPCPVWEQ	NEU3	81	Q9UQ49
PLWHVGMNDVLPNSP	TAFAZZIN	181	Q16635
DPFNPQAWRMAAHSP	TTYH2	431	Q9BSA4
QAWRMAAHSPPRGQL	TTYH2	436	Q9BSA4
PGQNWAGMAAPRLPS	PRSS42P	21	Q7Z5A4
MEGLPAPNNNPAARW	SPTBN4	11	Q9H254
PDSPATGAHWMRQPV	TBX6	176	O95947
THWEQGPNMPTPEQH	nan	611	Q3C1V9
MPPGRWHAAYPAQAQ	ZNF445	1	P59923
SRQQNAPLPPWAHSM	ZCCHC18	11	P0CG32
LQRSQAAPWAPAPAM	ZNF74	156	Q16587
QPGNMSHPRPWLGLD	USP7	1066	Q93009
RNMPDPHNLPIVAGW	SLC36A4	256	Q6YBV0
WPERGPPAPRHQEMA	ZNF500	196	O60304
GPQPNPRAWECHRMK	nan	21	Q6ZRX8
PRAWECHRMKGPQPN	nan	26	Q6ZRX8
CHRMKGPQPNPRAWE	nan	31	Q6ZRX8
MWPQMHLPDGRAQPG	TRERF1	476	Q96PN7
WATPNMAAHPLLNLP	NAF1	451	Q96HR8
PVWAPHPTDGFQMGN	MYO6	6	Q9UM54