Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	stereocilium tip	ESPNL STRC STRCP1	1.08e-04	22	89	3	GO:0032426
GeneOntologyCellularComponent	actin-based cell projection	TGFB1 ESPNL CDHR5 STRC SHTN1 ADGRA2 STRCP1	1.86e-04	278	89	7	GO:0098858
Domain	Caskin_C	CASKIN2 CASKIN1	2.05e-05	2	85	2	IPR032117
Domain	Caskin-tail	CASKIN2 CASKIN1	2.05e-05	2	85	2	PF16632
Domain	SAM_1	SHANK1 CASKIN2 CASKIN1 PPFIA3	2.61e-04	68	85	4	PF00536
Domain	DUF3669_Znf	ZNF746 ZNF398	3.03e-04	6	85	2	IPR022137
Domain	DUF3669	ZNF746 ZNF398	3.03e-04	6	85	2	PF12417
Domain	Ank_2	SHANK1 CASKIN2 CASKIN1 ESPNL TP53BP2 PPP1R16A	4.45e-04	215	85	6	PF12796
Domain	SH3	SHANK1 CASKIN2 PIK3R2 CASKIN1 TP53BP2 RUSC2	4.57e-04	216	85	6	SM00326
Domain	SH3	SHANK1 CASKIN2 PIK3R2 CASKIN1 TP53BP2 RUSC2	4.57e-04	216	85	6	PS50002
Domain	SH3_domain	SHANK1 CASKIN2 PIK3R2 CASKIN1 TP53BP2 RUSC2	5.03e-04	220	85	6	IPR001452
Domain	Ank	SHANK1 CASKIN2 CASKIN1 ESPNL TP53BP2 PPP1R16A	6.07e-04	228	85	6	PF00023
Domain	SH3_2	SHANK1 CASKIN2 CASKIN1 RUSC2	6.39e-04	86	85	4	IPR011511
Domain	SH3_2	SHANK1 CASKIN2 CASKIN1 RUSC2	6.39e-04	86	85	4	PF07653
Domain	SAM	SHANK1 CASKIN2 CASKIN1 PPFIA3	6.97e-04	88	85	4	SM00454
Domain	SAM_DOMAIN	SHANK1 CASKIN2 CASKIN1 PPFIA3	9.28e-04	95	85	4	PS50105
Domain	-	SHANK1 CASKIN2 CASKIN1 ESPNL TP53BP2 PPP1R16A	9.40e-04	248	85	6	1.25.40.20
Domain	ANK	SHANK1 CASKIN2 CASKIN1 ESPNL TP53BP2 PPP1R16A	1.00e-03	251	85	6	SM00248
Domain	SAM	SHANK1 CASKIN2 CASKIN1 PPFIA3	1.00e-03	97	85	4	IPR001660
Domain	ANK_REPEAT	SHANK1 CASKIN2 CASKIN1 ESPNL TP53BP2 PPP1R16A	1.04e-03	253	85	6	PS50088
Domain	Ankyrin_rpt-contain_dom	SHANK1 CASKIN2 CASKIN1 ESPNL TP53BP2 PPP1R16A	1.06e-03	254	85	6	IPR020683
Domain	ANK_REP_REGION	SHANK1 CASKIN2 CASKIN1 ESPNL TP53BP2 PPP1R16A	1.06e-03	254	85	6	PS50297
Domain	Ankyrin_rpt	SHANK1 CASKIN2 CASKIN1 ESPNL TP53BP2 PPP1R16A	1.25e-03	262	85	6	IPR002110
Domain	-	SHANK1 CASKIN2 CASKIN1 PPFIA3	1.39e-03	106	85	4	1.10.150.50
Domain	SAM/pointed	SHANK1 CASKIN2 CASKIN1 PPFIA3	2.00e-03	117	85	4	IPR013761
Domain	PAS-assoc_C	KCNH2 NPAS1	5.29e-03	24	85	2	IPR000700
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZXDC NCOR2 EHBP1L1 PNPLA6 PCNX3 KCNH2 POLG CASKIN1 MEX3D OSBPL5 ZNF398 NBL1 HES6 PPP6R1 MBD6 TESK1 ADGRA2 PKN3 C6orf132 PCNT PPP1R16A RAB11FIP3	1.62e-13	1105	94	22	35748872
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	NCOR2 ZNF469 CUX2 PIK3R2 PLCH2 IRF2BPL BSN NEURL4 PRRC1 TP53BP2 C6orf132 PCNT	2.10e-09	430	94	12	35044719
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 NCOR2 ZNF219 SGIP1 CASKIN1 DIAPH1 PPP6R1 PPFIA3 BSN SHTN1 RTN1 NEURL4 TP53BP2 PCNT	3.17e-07	963	94	14	28671696
Pubmed	TSC22D4 promotes TGFβ1-induced activation of hepatic stellate cells.	TGFB1 TSC22D4	7.23e-06	2	94	2	35714570
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	7.23e-06	2	94	2	34910522
Pubmed	Structural and Biochemical Basis for the Inhibitory Effect of Liprin-α3 on Mouse Diaphanous 1 (mDia1) Function.	DIAPH1 PPFIA3	7.23e-06	2	94	2	25911102
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	7.23e-06	2	94	2	11687802
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	2.16e-05	3	94	2	30801007
Pubmed	Molecular cloning of an avian anti-Müllerian hormone homologue.	TGFB1 INHBB	2.16e-05	3	94	2	8918254
Pubmed	CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein.	CASKIN2 CASKIN1	2.16e-05	3	94	2	12040031
Pubmed	An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma.	TGFB1 INHBB	2.16e-05	3	94	2	31328883
Pubmed	Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.	CASKIN2 CASKIN1	2.16e-05	3	94	2	31727973
Pubmed	Biallelic expression of HRAS and MUCDHL in human and mouse.	DUSP8 CDHR5	2.16e-05	3	94	2	12589428
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	ATXN2L EHBP1L1 CASKIN2 USP43 LRATD2 PPP1R37 SHTN1 TP53BP2 C6orf132	2.31e-05	565	94	9	25468996
Pubmed	Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.	HOXA4 NCOR2 UNCX	2.45e-05	21	94	3	30254164
Pubmed	Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.	WIPF1 PIK3R2 IRF2BPL	4.21e-05	25	94	3	12029088
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	4.32e-05	4	94	2	18849963
Pubmed	DUSP8 induces TGF-β-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α.	TGFB1 DUSP8	4.32e-05	4	94	2	37909329
Pubmed	A variant in the fibrillin-3 gene is associated with TGF-β and inhibin B levels in women with polycystic ovary syndrome.	TGFB1 INHBB	4.32e-05	4	94	2	20630504
Pubmed	Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B.	NCOR2 HIC1	4.32e-05	4	94	2	10611298
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	ATXN2L SGIP1 STXBP5 CASKIN1 BSN RTN1 RUSC2	4.51e-05	347	94	7	17114649
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	CASKIN1 SORCS2 ZNF398 CHPF2 EIF2AK4	6.18e-05	153	94	5	10718198
Pubmed	ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.	TGFB1 TP53BP2	7.19e-05	5	94	2	28400336
Pubmed	Expression of activins and TGF beta 1 and beta 2 RNAs in early postimplantation mouse embryos and uterine decidua.	TGFB1 INHBB	7.19e-05	5	94	2	1373953
Pubmed	IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ.	SHANK1 BSN	7.19e-05	5	94	2	21940441
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	7.19e-05	5	94	2	24920589
Pubmed	The synaptic vesicle cycle.	STXBP5 PPFIA3 BSN	8.14e-05	31	94	3	15217342
Pubmed	The DNA sequence and analysis of human chromosome 13.	PRR20C PRR20D PRR20B PRR20E PRR20A	1.02e-04	170	94	5	15057823
Pubmed	The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development.	KIF12 PCNT	1.08e-04	6	94	2	22851319
Pubmed	Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis.	NCOR2 UNCX	1.08e-04	6	94	2	27506116
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ATXN2L CASKIN2 USP43 TSC22D4 SHTN1 TESK1 PRRC1 TP53BP2 C6orf132 RUSC2	1.14e-04	861	94	10	36931259
Pubmed	Effects of TGFbeta2 on wild-type and Tgfbr3 knockout mouse fetal testis.	TGFB1 INHBB	1.50e-04	7	94	2	23303681
Pubmed	Functional analysis of mammalian members of the transforming growth factor-beta superfamily.	TGFB1 INHBB	1.50e-04	7	94	2	18406693
Pubmed	Endogenous inhibins regulate steroidogenesis in mouse TM3 Leydig cells by altering SMAD2 signalling.	TGFB1 INHBB	1.50e-04	7	94	2	27465829
Pubmed	Identification of a shootin1 isoform expressed in peripheral tissues.	BHLHA15 SHTN1	2.00e-04	8	94	2	27177867
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	2.00e-04	8	94	2	21165971
Pubmed	Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea.	SHANK1 BSN	2.00e-04	8	94	2	23217150
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	NCOR2 ZNF469 ZNF219 PNPLA6 PIK3R2 DIAPH1 C16orf96 CHPF2 PPP6R1 PPFIA3 KIF18B	2.15e-04	1116	94	11	31753913
Pubmed	Superresolution imaging of chemical synapses in the brain.	SHANK1 BSN	2.57e-04	9	94	2	21144999
Pubmed	Development and distribution of neuronal cilia in mouse neocortex.	TGFB1 PCNT	3.21e-04	10	94	2	22020803
Pubmed	Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.	TGFB1 ADGRA2	3.21e-04	10	94	2	21282641
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	MEX3D PPP6R1 PPFIA3 BSN TP53BP2	3.23e-04	218	94	5	33378226
Pubmed	90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.	PIK3R2 RTN1	3.91e-04	11	94	2	15117958
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	3.91e-04	11	94	2	31776257
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	3.91e-04	11	94	2	31448880
Pubmed	Genomic analysis of mouse retinal development.	NCOR2 ZNF219 PCNX3 INHBB RP1L1 DUSP8 SORCS2 HES6 BSN RTN1	3.95e-04	1006	94	10	15226823
Pubmed	Proteomic analysis of in vivo phosphorylated synaptic proteins.	SGIP1 BSN RTN1	4.06e-04	53	94	3	15572359
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	EHBP1L1 ZNF219 INHBB PPP1R37 NBL1 HES6 C1orf159 CDHR5 BTBD2 RAB11FIP3	4.43e-04	1021	94	10	26760575
Pubmed	Cellular patterns of transcription factor expression in developing cortical interneurons.	CUX2 NPAS1	4.69e-04	12	94	2	16766712
Pubmed	Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development.	TGFB1 INHBB	4.69e-04	12	94	2	23342175
Pubmed	Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.	ZNF469 ADGRA2 PKN3	5.30e-04	58	94	3	24144296
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	NCOR2 CASKIN2 DUSP8 PPP1R37 EIF2AK4 PPP6R1 PPFIA3 NEURL4 TP53BP2 PCNT	5.47e-04	1049	94	10	27880917
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CASKIN2 PLCH2 CASKIN1 OSBPL5 EIF2AK4 BSN ADGRA2	5.93e-04	529	94	7	14621295
Pubmed	Regulation of the ovarian reserve by members of the transforming growth factor beta family.	TGFB1 INHBB	6.44e-04	14	94	2	22847922
Pubmed	Developmental changes in extracellular matrix messenger RNAs in the mouse placenta during the second half of pregnancy: possible factors involved in the regulation of placental extracellular matrix expression.	TGFB1 INHBB	8.46e-04	16	94	2	17881772
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	9.57e-04	17	94	2	20856818
Pubmed	Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition.	TGFB1 INHBB	1.08e-03	18	94	2	9716414
Pubmed	Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.	SYNPO2L DIAPH1 PRRC1 TP53BP2	1.30e-03	174	94	4	29669786
Pubmed	Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.	INHBB LRATD2	1.33e-03	20	94	2	23326517
Pubmed	Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.	TGFB1 BHLHA15 HS3ST4	1.40e-03	81	94	3	39217171
Pubmed	Ectodysplasin-A signaling is a key integrator in the lacrimal gland-cornea feedback loop.	TGFB1 BHLHA15	1.47e-03	21	94	2	31221639
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	TGFB1 USP43 PKN3 TP53BP2 C6orf132	1.50e-03	307	94	5	37499664
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZXDC CUX2 ZNF219 BHLHA15 ZNF398 HES6 TSC22D4 ZNF367	1.58e-03	808	94	8	20412781
Pubmed	The apical complex couples cell fate and cell survival to cerebral cortical development.	CUX2 PCNT	1.61e-03	22	94	2	20399730
Pubmed	Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs.	HOXA4 UNCX	1.61e-03	22	94	2	26283362
Pubmed	The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.	BSN NPAS1	1.61e-03	22	94	2	37532091
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SHANK1 ATXN2L SGIP1 PNPLA6 CASKIN1 SORCS2 PPFIA3 TSC22D4 BSN RTN1 TP53BP2	1.67e-03	1431	94	11	37142655
Pubmed	Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination.	TGFB1 INHBB	1.76e-03	23	94	2	24917498
Pubmed	Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.	BHLHA15 HES6 NPAS1	2.42e-03	98	94	3	18557763
Interaction	ZNF683 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	3.93e-10	10	90	5	int:ZNF683
Interaction	CELF4 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	7.18e-10	11	90	5	int:CELF4
Interaction	BEND2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.23e-09	12	90	5	int:BEND2
Interaction	C3orf36 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A PPP1R16A	1.44e-09	26	90	6	int:C3orf36
Interaction	PTTG2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	3.08e-09	14	90	5	int:PTTG2
Interaction	MBNL3 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	6.67e-09	16	90	5	int:MBNL3
Interaction	SH3RF1 interactions	PRR20C PRR20D PRR20B WIPF1 PRR20E SYNPO2L PRR20A TP53BP2	2.82e-08	108	90	8	int:SH3RF1
Interaction	PRR34 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	3.05e-08	21	90	5	int:PRR34
Interaction	TPRX1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	3.05e-08	21	90	5	int:TPRX1
Interaction	OXER1 interactions	PRR20C PRR20D PRR35 PRR20B PRR20E PRR20A	9.09e-08	50	90	6	int:OXER1
Interaction	KRTAP19-5 interactions	PRR20C PRR20D PRR20B PRR20E MAPK1IP1L PRR20A PPP1R16A	2.98e-07	99	90	7	int:KRTAP19-5
Interaction	ZNF385C interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	3.41e-07	33	90	5	int:ZNF385C
Interaction	TOP3B interactions	ZXDC NCOR2 EHBP1L1 PNPLA6 PCNX3 KCNH2 POLG CASKIN1 MEX3D OSBPL5 ZNF398 NBL1 HES6 PPP6R1 MBD6 TESK1 ADGRA2 PKN3 C6orf132 PCNT PPP1R16A RAB11FIP3	3.56e-07	1470	90	22	int:TOP3B
Interaction	HLX interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	6.18e-07	37	90	5	int:HLX
Interaction	ZCCHC14 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	6.18e-07	37	90	5	int:ZCCHC14
Interaction	TBX6 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.05e-06	41	90	5	int:TBX6
Interaction	FAM222B interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.19e-06	42	90	5	int:FAM222B
Interaction	SAMD11 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.34e-06	43	90	5	int:SAMD11
Interaction	BICRAL interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.34e-06	43	90	5	int:BICRAL
Interaction	SP4 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.88e-06	46	90	5	int:SP4
Interaction	PRR35 interactions	PRR20C PRR20D PRR35 PRR20B PRR20E PRR20A	1.92e-06	83	90	6	int:PRR35
Interaction	RBPMS2 interactions	PRR20C PRR20D PRR20B PRR20E PPP1R37 PRR20A	1.92e-06	83	90	6	int:RBPMS2
Interaction	KRTAP19-1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	2.10e-06	47	90	5	int:KRTAP19-1
Interaction	PRR20B interactions	PRR20C PRR20D PRR35 PRR20B PRR20E PRR20A	3.09e-06	90	90	6	int:PRR20B
Interaction	PRR20C interactions	PRR20C PRR20D PRR35 PRR20B PRR20E PRR20A	3.09e-06	90	90	6	int:PRR20C
Interaction	PRR20D interactions	PRR20C PRR20D PRR35 PRR20B PRR20E PRR20A	3.09e-06	90	90	6	int:PRR20D
Interaction	RBM23 interactions	PRR20C PRR20D PRR20B PRR20E BHLHA15 PRR20A	3.98e-06	94	90	6	int:RBM23
Interaction	RIPPLY1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	4.63e-06	55	90	5	int:RIPPLY1
Interaction	ZBTB32 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	6.04e-06	58	90	5	int:ZBTB32
Interaction	PRR20E interactions	PRR20C PRR20D PRR35 PRR20B PRR20E PRR20A	6.04e-06	101	90	6	int:PRR20E
Interaction	FAM9A interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	6.57e-06	59	90	5	int:FAM9A
Interaction	C1orf94 interactions	PRR20C PRR20D PRR20B PRR20E MAPK1IP1L PRR20A	6.77e-06	103	90	6	int:C1orf94
Interaction	CABP2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	7.76e-06	61	90	5	int:CABP2
Interaction	FOXH1 interactions	PRR20C PRR20D PRR20B PRR20E PPP1R37 PRR20A	9.38e-06	109	90	6	int:FOXH1
Interaction	PRR20A interactions	PRR20C PRR20D PRR35 PRR20B PRR20E PRR20A	9.38e-06	109	90	6	int:PRR20A
Interaction	C10orf55 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.06e-05	65	90	5	int:C10orf55
Interaction	PHF1 interactions	HIC1 PRR20C PRR20D PRR20B PRR20E PRR20A TP53BP2	1.20e-05	172	90	7	int:PHF1
Interaction	SMAP1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.23e-05	67	90	5	int:SMAP1
Interaction	TBX3 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.42e-05	69	90	5	int:TBX3
Interaction	NCK2 interactions	PRR20C PRR20D PRR20B WIPF1 CASKIN2 PRR20E PRR20A MBD6	2.27e-05	262	90	8	int:NCK2
Interaction	ESRP1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	2.44e-05	77	90	5	int:ESRP1
Interaction	CCNK interactions	PRR20C PRR20D PRR20B PRR20E PRR20A TSC22D4	2.80e-05	132	90	6	int:CCNK
Interaction	VPS37C interactions	PRR20C PRR20D PRR20B PRR20E MAPK1IP1L PRR20A	4.05e-05	141	90	6	int:VPS37C
Interaction	TCF7L2 interactions	HIC1 PRR20C PRR20D PRR20B PRR20E PRR20A HES6 NPAS1	4.12e-05	285	90	8	int:TCF7L2
Interaction	FAM168A interactions	PRR20C PRR20D PRR20B PRR20E PRR20A TP53BP2	4.21e-05	142	90	6	int:FAM168A
Interaction	DMRT3 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	4.40e-05	87	90	5	int:DMRT3
Interaction	MAGED1 interactions	PRR20C PRR20D PRR35 PRR20B PRR20E MAPK1IP1L PRR20A NPAS1	5.26e-05	295	90	8	int:MAGED1
Interaction	RGMA interactions	NCOR2 TP53BP2 PPP1R16A	7.92e-05	19	90	3	int:RGMA
Interaction	PATZ1 interactions	PRR20C PRR20D PRR20B PRR20E PPP1R37 PRR20A	9.07e-05	163	90	6	int:PATZ1
Interaction	TRIM35 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	9.85e-05	103	90	5	int:TRIM35
Interaction	GTF2A1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.03e-04	104	90	5	int:GTF2A1
Interaction	RHOXF2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.03e-04	104	90	5	int:RHOXF2
Interaction	VENTX interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.03e-04	104	90	5	int:VENTX
Interaction	VEZF1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.08e-04	105	90	5	int:VEZF1
Interaction	GLIS2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.13e-04	106	90	5	int:GLIS2
Interaction	LASP1 interactions	NCOR2 PRR20C PRR20D PRR35 PRR20B PRR20E PRR20A	1.20e-04	247	90	7	int:LASP1
Interaction	TIAL1 interactions	PRR20C PRR20D PRR20B PRR20E MAPK1IP1L PRR20A	1.22e-04	172	90	6	int:TIAL1
Interaction	POU2F1 interactions	NCOR2 PRR20C PRR20D PRR20B PRR20E PRR20A	1.34e-04	175	90	6	int:POU2F1
Interaction	NOTCH3 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.52e-04	113	90	5	int:NOTCH3
Interaction	CDH1 interactions	TGFB1 ATXN2L EHBP1L1 CASKIN2 DIAPH1 USP43 LRATD2 PPP1R37 C16orf96 SHTN1 TP53BP2 C6orf132	1.54e-04	768	90	12	int:CDH1
Interaction	TFG interactions	PRR20C PRR20D EHBP1L1 PRR20B PRR20E MAPK1IP1L PRR20A	1.57e-04	258	90	7	int:TFG
Interaction	DAZAP2 interactions	PRR20C PRR20D PRR20B PRR20E MAPK1IP1L PRR20A	1.87e-04	186	90	6	int:DAZAP2
Interaction	BHLHE40 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.94e-04	119	90	5	int:BHLHE40
Interaction	THAP1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	1.94e-04	119	90	5	int:THAP1
Interaction	HYPK interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	2.44e-04	125	90	5	int:HYPK
Interaction	PITX1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	2.63e-04	127	90	5	int:PITX1
Interaction	VAC14 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A NEURL4	2.84e-04	201	90	6	int:VAC14
Interaction	ABI2 interactions	PRR20C PRR20D PRR20B WIPF1 CASKIN2 PRR20E PRR20A	2.95e-04	286	90	7	int:ABI2
Interaction	YPEL3 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	3.26e-04	133	90	5	int:YPEL3
Interaction	TLX3 interactions	NCOR2 PRR20C PRR20D PRR20B PRR20E PRR20A TSC22D4	3.27e-04	291	90	7	int:TLX3
Interaction	YWHAH interactions	ATXN2L CASKIN2 KCNH2 MEX3D OSBPL5 USP43 TSC22D4 SHTN1 TESK1 PRRC1 TP53BP2 C6orf132 PCNT RUSC2	3.63e-04	1102	90	14	int:YWHAH
Interaction	ANKHD1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A NPAS1	4.16e-04	216	90	6	int:ANKHD1
Interaction	SIAH1 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A TP53BP2	4.93e-04	223	90	6	int:SIAH1
Interaction	ARID5A interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	5.15e-04	147	90	5	int:ARID5A
Interaction	POU6F2 interactions	PRR20C PRR20D PRR20B PRR20E PRR20A	5.31e-04	148	90	5	int:POU6F2
Interaction	SETD5 interactions	PRR20E PRR20A TP53BP2	6.00e-04	37	90	3	int:SETD5
Interaction	NPAS1 interactions	NCOR2 EHBP1L1 CASKIN2 MEX3D PPP6R1 NPAS1	8.07e-04	245	90	6	int:NPAS1
Cytoband	13q21.1	PRR20C PRR20D PRR20B PRR20E PRR20A	4.10e-11	13	94	5	13q21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr13q21	PRR20C PRR20D PRR20B PRR20E PRR20A	4.52e-06	117	94	5	chr13q21
Cytoband	7q36.1	KCNH2 ZNF746 ZNF398 CHPF2	1.70e-05	74	94	4	7q36.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q36	KCNH2 ZNF746 ZNF398 CHPF2	3.32e-04	159	94	4	chr7q36
Cytoband	15q15.3	STRC STRCP1	1.21e-03	25	94	2	15q15.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ATP8B3 PRSS57 PNPLA6 C19orf67 PIK3R2 MEX3D BTBD2	1.28e-03	797	94	7	chr19p13
Cytoband	19p13.3	ATP8B3 PRSS57 MEX3D BTBD2	1.47e-03	237	94	4	19p13.3
Cytoband	16p13.3	PRR35 CASKIN1 C16orf96 RAB11FIP3	1.63e-03	244	94	4	16p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	EIF2AK4 STRC STRCP1	3.48e-03	147	94	3	chr15q15
GeneFamily	Ankyrin repeat domain containing	SHANK1 CASKIN2 CASKIN1 ESPNL TP53BP2 PPP1R16A	1.35e-04	242	59	6	403
GeneFamily	Sterile alpha motif domain containing	SHANK1 CASKIN2 CASKIN1 PPFIA3	1.94e-04	88	59	4	760
Coexpression	GSE33374_CD8_ALPHAALPHA_VS_ALPHABETA_CD161_HIGH_TCELL_UP	TGFB1 HOXA4 CUX2 CEL KCNH2 NEURL4 NPAS1	5.74e-06	199	90	7	M8538
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000_k-means-cluster#2	SHANK1 CUX2 KCNH2 IRF2BPL SHTN1 ZNF367 RUSC2	2.50e-05	210	87	7	Facebase_RNAseq_e9.5_Olfactory Placode_1000_K2
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Biphasic\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	HIC1 ZNF469 COL20A1 RP1L1 ADGRA2 PKN3	1.23e-06	167	91	6	9062577a4b7902c9a888d706589d1b05221c0fa8
Disease	obsolete aging, cognition	PRR20C PRR20D PRR20B PRR20E PRR20A	6.53e-10	15	89	5	EFO_0003925, GO_0007568
Disease	t-tau:beta-amyloid 1-42 ratio measurement	PRR20C PRR20D PRR20B SGIP1 PRR20E PRR20A	4.99e-08	66	89	6	EFO_0007708
Disease	Tinnitus, wellbeing measurement	PRR20C PRR20D PRR20B PRR20E STXBP5 PRR20A	4.73e-07	96	89	6	EFO_0007869, HP_0000360
Disease	Nonorganic psychosis	TGFB1 SHANK1 KCNH2 PCNT NPAS1	2.15e-06	69	89	5	C0349204
Disease	mosaic loss of chromosome Y measurement	PRR20C PRR20D PRR20B PRR20E PRR20A	4.48e-06	80	89	5	EFO_0007783
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	9.00e-06	2	89	2	DOID:0110471 (implicated_via_orthology)
Disease	Psychotic Disorders	TGFB1 SHANK1 KCNH2 PCNT NPAS1	1.41e-05	101	89	5	C0033975
Disease	stem Cell Growth Factor-beta measurement	SHANK1 RAB11FIP3	8.94e-05	5	89	2	EFO_0802090
Disease	stem cell growth factor-alpha measurement	SHANK1 RAB11FIP3	1.87e-04	7	89	2	EFO_0020754
Disease	Vitiligo, response to rhododendrol	MAPK1IP1L PPFIA3	6.87e-04	13	89	2	EFO_0004208, EFO_0010824
Disease	mean arterial pressure	CUX2 SGIP1 PCNX3 STXBP5 SYNPO2L PRSS42P EIF2AK4	7.92e-04	499	89	7	EFO_0006340
Disease	JT interval	ATXN2L PRR35 SGIP1 KCNH2 TSC22D4	9.42e-04	248	89	5	EFO_0007885
Disease	response to triptolide, cytotoxicity measurement	ADGRA2 TP53BP2	1.05e-03	16	89	2	EFO_0006952, EFO_0007662
Disease	QT interval	ATXN2L PRR35 SGIP1 KCNH2 SYNPO2L TSC22D4 NEURL4	1.17e-03	534	89	7	EFO_0004682
Disease	Paroxysmal atrial fibrillation	WIPF1 KCNH2 SYNPO2L IRF2BPL	1.29e-03	156	89	4	C0235480
Disease	familial atrial fibrillation	WIPF1 KCNH2 SYNPO2L IRF2BPL	1.29e-03	156	89	4	C3468561
Disease	Persistent atrial fibrillation	WIPF1 KCNH2 SYNPO2L IRF2BPL	1.29e-03	156	89	4	C2585653
Disease	Atrial Fibrillation	WIPF1 KCNH2 SYNPO2L IRF2BPL	1.42e-03	160	89	4	C0004238
Disease	serum gamma-glutamyl transferase measurement	TGFB1 NCOR2 CUX2 SGIP1 PCNX3 BHLHA15 RP1L1 FCRLA PKN3	1.76e-03	914	89	9	EFO_0004532
Disease	cardioembolic stroke	NCOR2 WIPF1 KCNH2 SYNPO2L	1.77e-03	170	89	4	EFO_1001976
Disease	mean corpuscular hemoglobin concentration	CUX2 EHBP1L1 PRR35 RP1L1 C16orf96 EIF2AK4 PPP6R1 ZNF367 PPP1R16A SLC16A10	1.82e-03	1105	89	10	EFO_0004528
Disease	osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty	TGFB1 NCOR2	1.82e-03	21	89	2	EFO_0004616, EFO_0010726, EFO_1000786
Disease	hypertension	NCOR2 HIC1 CUX2 STXBP5 SORCS2	2.40e-03	307	89	5	EFO_0000537
Disease	telomere length	PRR20C PRR20D PRR20B PRR20E PRR20A	2.61e-03	313	89	5	EFO_0004505
Disease	migraine disorder, pulse pressure measurement	TGFB1 HIC1	2.79e-03	26	89	2	EFO_0005763, MONDO_0005277

Protein segments in the cluster

Peptide	Gene	Start	Entry
LGPAPAPPGPVSPEG	ADPGK	41	Q9BRR6
SEQRPGTPGPPPPEG	CTAG2	176	O75638
RPAGPGTPPPDSGPL	EIF2AK4	661	Q9P2K8
TRPGSPGQNPPPEPE	ADGRA2	571	Q96PE1
GLSAGGEPPAPPTPP	DUSP8	351	Q13202
PGEGTPDGSLPNPGP	BHLHA15	21	Q7RTS1
PEPSPAPPGPGDTGD	ATP8B3	16	O60423
EPAPPGPASPGGAPE	CDHR5	746	Q9HBB8
SGDATIPPPPPLPEG	DIAPH1	646	O60610
GAPPVPPTGDSGAPP	CEL	611	P19835
PPTGDSGAPPVPPTG	CEL	616	P19835
AGPPPVPPTGDSGAP	CEL	676	P19835
ATPAPGPEPLGGPEP	CUX2	521	O14529
PPPYPSGEPEGPGED	TP53BP2	871	Q13625
GGTEGPEQPPPPCPS	ATXN2L	616	Q8WWM7
AGAPGAPEPEPEPEP	RAB42	31	Q8N4Z0
GSEPPGPDPEPGGPD	RAB11FIP3	11	O75154
APGSPIPSPPGPGDD	HES6	166	Q96HZ4
SPGPEPTEPEPPTEG	NPAS1	431	Q99742
ATLGADGPPPGPPTP	NCOR2	771	Q9Y618
PPDPTGAPLPGPTGD	PNPLA6	386	Q8IY17
EGEVGPAAPGPAPPP	CASKIN1	841	Q8WXD9
SPGPPSPPSEGPRLG	ESPNL	781	Q6ZVH7
PLNGGPGSLPPEPPS	MBD6	156	Q96DN6
SGSPGPEPPGRPDGP	HIC1	311	Q14526
GPPPQGEGVPVPPSL	KIF12	116	Q96FN5
EGPAIPGDTPPPTPR	PPFIA3	706	O75145
PPPPPGSPGGSQDTC	INHBB	41	P09529
VPFSSPRPPGEPPGG	KCNH2	956	Q12809
SVSQLPPEPPGPPGF	BSN	1601	Q9UPA5
PNGFPKPTPEEGPPE	IRF2BPL	196	Q9H1B7
PPGGPAPEGSDTDPP	PCNX3	326	Q9H6A9
AEGQAPDPSPAPGPP	EHBP1L1	1311	Q8N3D4
QQPPGGSSPSEEPPP	EHBP1L1	1331	Q8N3D4
EDPGPGPAPPPEGAQ	MEX3D	26	Q86XN8
DGGDGPPPPQPQPYD	LRATD2	61	Q96KN1
GSPQPEPHAPEPGPG	MFSD2B	11	A6NFX1
PHPGGQTPEPEDPPG	NBL1	156	P41271
EGGGQPPPQDLPGSP	KIF18B	391	Q86Y91
PEPPSGSPPEGPEIQ	PCNT	1626	O95613
TLSEPAGPSEPPGPP	CASKIN2	906	Q8WXE0
DPGGPETPGPEGPLP	PRR35	376	P0CG20
GSSEPQPPPEPPRSG	PPP1R37	616	O75864
TGPPPGTVQEGPGPD	PRR20D	141	P86480
TGPPPGTVQEGPGPD	PRR20A	141	P86496
TGPPPGTVQEGPGPD	PRR20B	141	P86481
PSSPPPGGAPDGSEP	PIK3R2	261	O00459
PAPGEGPPPGTVLEP	RGL4	176	Q8IZJ4
PAPGPPQDISEPPGG	C6orf132	146	Q5T0Z8
GPVPAPGAQPPPLGD	C16orf96	371	A6NNT2
CSSETPGPPGPQGPP	COL20A1	1066	Q9P218
APGTAPEEAPGPLPP	FCRLA	281	Q7L513
GETPPPDALEPGTPP	C19orf67	16	A6NJJ6
GPTPPAPPGPGTDAQ	BTBD2	56	Q9BX70
SGSRPPLPGSPGDPP	C1orf159	236	Q96HA4
GGASPGRPPQPEQPP	HOXA4	106	Q00056
PPEPPEQPAAPGTDG	HS3ST4	111	Q9Y661
TPGPPSAALGEPPDP	NEURL4	1521	Q96JN8
PGPGPGPAEPVASGP	PKN3	81	Q6P5Z2
PNGPSLPRDEGPPTP	OSBPL5	51	Q9H0X9
TVPGPGPTGPYPTPN	MAPK1IP1L	106	Q8NDC0
PGPGPDPGPSQPSEY	RUSC2	431	Q8N2Y8
PSTEPQPGPELPPGD	RTN1	526	Q16799
GQPGPALPPPGPEAE	POLG	151	A0A3B3IS91
GPTRPTPPGAPPDEV	SYNPO2L	161	Q9H987
GPGSPGASDPPTPQP	TSC22D4	21	Q9Y3Q8
TGPPPGTVQEGPGPD	PRR20C	141	P86479
PSPGPAPGPGEDGAP	SORCS2	96	Q96PQ0
SPQPGPLPGTTRPPG	PRSS57	266	Q6UWY2
TGPPPGTVQEGPGPD	PRR20E	141	P86478
PPPEGPESPETAEPG	PPP1R16A	471	Q96I34
NSPSPPTPEPGEGPR	SHTN1	531	A0MZ66
GIETTPPGTPPPNPA	PRRC1	6	Q96M27
TPEGEQPPPLPTPVG	STXBP5	556	Q5T5C0
GEGPVGEPPPLQPPA	STRC	76	Q7RTU9
PQPGPDPPPGTDSGI	SHANK1	1661	Q9Y566
SPQRSPPGPPGAGPD	CHPF2	631	Q9P2E5
GAGPDPPSPPGADPS	CHPF2	641	Q9P2E5
APGSPGEERPPGPQP	USP43	71	Q70EL4
PGARPGEASGPSPPP	ZXDC	51	Q2QGD7
ERPGPSNPPVGPAPG	RP1L1	276	Q8IWN7
DNPADSPAPGPLGPP	SGIP1	341	Q9BQI5
DDVVPPGPGPAPEAP	PLCH2	961	O75038
PGPGPAPEAPAQEGP	PLCH2	966	O75038
SPPSQGEVPPGPLPE	TGFB1	61	P01137
GDSDPSGQPPNPPGP	ZNF398	596	Q8TD17
GQPDPAPRPGPPAGT	MOSPD3	146	O75425
PEASPAPGPEAGPPL	PRSS42P	46	Q7Z5A4
PGPPPLPPSSSGNDE	WIPF1	316	O43516
EGSSPEPEPPGPAPQ	TESK1	471	Q15569
LTPPPIPNGSAPEGP	PPP6R1	861	Q9UPN7
GPPDTELAAPGPPPA	ZNF469	421	Q96JG9
PGPGEDRPPPRGSSP	ZNF469	3456	Q96JG9
GEGPVGEPPPLQPPA	STRCP1	76	A6NGW2
DVPVDPSPGSGPPVP	ZNF746	166	Q6NUN9
GGGEPEPPPPLIPTS	ZNF367	46	Q7RTV3
PPPGEDPGTTPPGHS	TNFRSF13C	146	Q96RJ3
EQRSGAGPGPPPEPP	ZNF219	551	Q9P2Y4
DSGGGGLSPEPPEPP	UNCX	236	A6NJT0
GTAPAPPGEPPAPGT	UNCX	266	A6NJT0
GAAPPPGPGPSDSPE	SLC16A10	26	Q8TF71