Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessribonucleoside bisphosphate biosynthetic process

ACACB HACD2 PAPSS1 ELOVL2

1.33e-0561494GO:0034030
GeneOntologyBiologicalProcesspurine nucleoside bisphosphate biosynthetic process

ACACB HACD2 PAPSS1 ELOVL2

1.33e-0561494GO:0034033
GeneOntologyBiologicalProcessnucleoside bisphosphate biosynthetic process

ACACB HACD2 PAPSS1 ELOVL2

1.33e-0561494GO:0033866
GeneOntologyBiologicalProcessthioester biosynthetic process

ACACB HACD2 ELOVL2

2.15e-0449493GO:0035384
GeneOntologyBiologicalProcessacyl-CoA biosynthetic process

ACACB HACD2 ELOVL2

2.15e-0449493GO:0071616
GeneOntologyBiologicalProcesspurine nucleoside bisphosphate metabolic process

ACACB HACD2 PAPSS1 ELOVL2

3.59e-04142494GO:0034032
GeneOntologyBiologicalProcessnucleoside bisphosphate metabolic process

ACACB HACD2 PAPSS1 ELOVL2

3.59e-04142494GO:0033865
GeneOntologyBiologicalProcessribonucleoside bisphosphate metabolic process

ACACB HACD2 PAPSS1 ELOVL2

3.59e-04142494GO:0033875
MousePhenoincreased fatty acid beta-oxidation

EPRS1 ACACB

4.53e-054392MP:0014173
DomainRossmann-like_a/b/a_fold

EPRS1 PAPSS1

5.46e-0343482IPR014729
Domain-

EPRS1 PAPSS1

5.46e-03434823.40.50.620
PathwayREACTOME_NEUREXINS_AND_NEUROLIGINS

LRRTM4 LRRTM3 GRM1

5.53e-0532333MM15326
Pubmed

LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding.

LRRTM4 LRRTM3

1.94e-06249226776509
Pubmed

The different roles of cyclinD1-CDK4 in STP and mGluR-LTD during the postnatal development in mice hippocampus area CA1.

GRM1 CDK4

5.83e-06349217535444
Pubmed

Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis.

LRRTM4 LRRTM3

1.16e-05449216860615
Pubmed

A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system.

LRRTM4 LRRTM3

1.94e-05549212676565
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

CNIH4 PSMG1 PIEZO1 DPY19L4 UGT8 NCEH1 HACD2 TMEM164 ATP9A

4.01e-05120149935696571
Pubmed

Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.

LRRTM4 ADGRB1 LRRTM3

5.53e-055249324613359
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

OR4D1 PAK2 HACD2 REEP4 COQ2 PAPSS1 USP3 SLC25A37 CDK4

8.64e-05132749932694731
Pubmed

Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.

PSMG1 GET1

1.27e-041249227100087
Pubmed

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

LRRTM4 LRRTM3 HACD2 GRM1 ATP9A

2.61e-0440549538187761
Pubmed

Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.

TENM1 GRM1

4.41e-042249235245678
Pubmed

Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).

ACACB SLC2A5

4.41e-042249220965718
Pubmed

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.

UGT8 ELOVL2

6.67e-042749225269881
Pubmed

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

PIEZO1 NCEH1 ATP9A CHRM2 CDK4

6.76e-0449949522810586
Pubmed

Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21.

PSMG1 GET1

8.25e-043049211374901
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

NBEAL1 PIEZO1 TENM1 ATP9A COQ2

1.06e-0355249510737800
InteractionFPR2 interactions

PIEZO1 HACD2 REEP4 ATP9A ELOVL2

1.70e-05138475int:FPR2
GeneFamilySolute carriers

SLC24A4 SLC25A37 SLC2A5

1.67e-02395253752
GeneFamilyFibronectin type III domain containing

USH2A CRLF2

2.04e-02160252555
ToppCellRV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

ACACB VWA8 NCEH1 LRRTM3 CHRM2

1.93e-0618749578cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCellLV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

ACACB VWA8 NCEH1 LRRTM3 CHRM2

1.98e-061884950758b474457efa36488e0195f7357100f4b6a090
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

ACACB VWA8 NCEH1 LRRTM3 CHRM2

2.04e-061894955e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellLV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

ACACB VWA8 NCEH1 LRRTM3 CHRM2

2.09e-06190495de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

ACACB VWA8 NCEH1 LRRTM3 CHRM2

2.20e-06192495ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCellCOVID-19-Fibroblasts-Mesothelial_FB|COVID-19 / group, cell type (main and fine annotations)

LRRTM4 LRRTM3 OR5AR1 USH2A

1.76e-051414947e6dcccb74e7ee90b69dc91b59491b84f3a713c9
ToppCellsevere_COVID-19-B_cell|World / disease group, cell group and cell class (v2)

ACACB UGT8 SLC2A5 CMTM8

1.85e-0514349428b0e168126a9fe60541dc12bfab385b7a0a2342
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCEH1 USH2A ELOVL2 SLC2A5

3.41e-05167494ed7e785dcd25777f64e0c2596ada4f5a5ea17121
ToppCelldroplet-Kidney-nan-18m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCEH1 USH2A ELOVL2 SLC2A5

3.57e-05169494f00741203efa0b948db7223ee8c19bdd0918258a
ToppCellRV-11._Adipocyte|World / Chamber and Cluster_Paper

ACACB HACD2 TMEM164 ATP9A

4.27e-05177494f0edf04930692418953e4f00a917257804ec0ffd
ToppCellLV|World / Chamber and Cluster_Paper

VWA8 NCEH1 LRRTM3 CHRM2

4.56e-051804945ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCellRV|World / Chamber and Cluster_Paper

ACACB NCEH1 LRRTM3 CHRM2

4.66e-05181494bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ACACB UGT8 TMEM164 GRM1

4.97e-05184494e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCellLV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

VWA8 NCEH1 LRRTM3 CHRM2

5.07e-051854946baccb26f999145e51b91d94315bf8d4655bef31
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ACACB UGT8 KCNK13 TMEM164

5.07e-05185494898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

VWA8 NCEH1 LRRTM3 CHRM2

5.51e-051894949c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

ACACB VWA8 LRRTM3 CHRM2

5.63e-05190494fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

ACACB VWA8 LRRTM3 CHRM2

5.74e-0519149425f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PCNX2 TENM1 GRM1 CHRM2

5.74e-051914945d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCellEntopeduncular-Neuronal-Inhibitory|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PCNX2 TENM1 GRM1 CHRM2

5.74e-0519149473dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCellsevere-Others-CD34+_GATA2+_cells|Others / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

EPRS1 PSMG1 SLC2A5 CDK4

5.86e-051924942e80755627d0350be8976324329e106e808d5574
ToppCell10x3'2.3-week_17-19-Hematopoietic-erythroid-early_erythroid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

EPRS1 PSMG1 SLC25A37 CDK4

6.60e-051984948d900a17667a41bdfa683a34275fe4c059f6a8ef
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLC24A4 DNAH17 TENM1 CMTM8

6.86e-05200494f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLC24A4 DNAH17 TENM1 CMTM8

6.86e-052004941639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLC24A4 DNAH17 TENM1 CMTM8

6.86e-0520049470a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Akr1c18_Ntf3|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CHRM2 PCTP CMTM8

7.76e-05754935edf024797a6dd9cbf9916a503194e29e0152d6c
Diseaseglioblastoma (is_implicated_in)

ADGRB1 CDK4

6.99e-0424482DOID:3068 (is_implicated_in)
Diseasereticulocyte count

EPRS1 VWA8 CNIH4 PIEZO1 DNAH17 USP3 SLC25A37

1.42e-031045487EFO_0007986
Diseasereticulocyte measurement

VWA8 CNIH4 PIEZO1 DNAH17 PAK2 USP3 SLC25A37

1.48e-031053487EFO_0010700
Diseaseatrial fibrillation

SLC24A4 PAK2 CATSPER3 USP3

3.09e-03371484EFO_0000275

Protein segments in the cluster

PeptideGeneStartEntry
SELSMKVYVDPINYW

CATSPER3

96

Q86XQ3
TLLMLVIIYVSVWRY

ADGRB1

961

O14514
YLPVIIMTVLYWHIS

CHRM2

196

P08172
VFSYIMVWLVTIIGY

SLC24A4

466

Q8NFF2
EWQVYIEKYIVPYMK

NBEAL1

1681

Q6ZS30
EGVYTILEWLSYMPK

ACACB

2001

O00763
LVITYPLMKRISYWP

COQ2

191

Q96H96
VAMILLVIYVSWKRY

LRRTM4

436

Q86VH4
LVIYVSWKRYPASMK

LRRTM4

441

Q86VH4
TIVKSYYWRVTMAPH

TMEM63C

376

Q9P1W3
YYWRVTMAPHPKDII

TMEM63C

381

Q9P1W3
SIIYYMVTSPKLLSW

PCNX2

1536

A6NKB5
PILPRYVMVKYWVDY

NCEH1

241

Q6PIU2
SLAGWKPSVYYVMLI

KCNK13

186

Q9HB14
IWVLISIYQGSTIMY

ATP9A

926

O75110
VFTASRWMVYYLKPS

CRLF2

106

Q9HC73
KPTEAGRLMAWYYIT

HFM1

776

A2PYH4
ETVVYWEVKYPFPMS

PCTP

96

Q9UKL6
WKIPAILYLCYTDVM

PSMG1

226

O95456
MAPKAWTVLTEYYKS

PAPSS1

606

O43252
TPYWMAPEVVTRKAY

PAK2

406

Q13177
MPQVSYLKAVDVYLW

GABRR3

321

A8MPY1
SLPWKDYVIYIDDMV

DNAH17

856

Q9UFH2
LTVMYLLSIWLGNKY

ELOVL2

41

Q9NXB9
SYQMALTPVVVTLWY

CDK4

166

P11802
YLVIYNVVMTAGWLV

HACD2

41

Q6Y1H2
MKSYTPYFILLWSAV

UGT8

1

Q16880
MISLIWKYYSVPVAV

GET1

116

O00258
MVIEGLKYIWIPYVC

DPY19L4

481

Q7Z388
AVYFTTKEWAIMVPA

KRBOX1

21

C9JBD0
ILMEKVSYSYPVDWF

GRK7

361

Q8WTQ7
MYTTCIIWLAFVPIY

GRM1

791

Q13255
VVSMIFIPCIYIYTW

OR4D1

246

Q15615
YEIKMAFVLWLLSPY

REEP4

66

Q9H6H4
SPWTKYEYRVLMSTL

USH2A

2691

O75445
TSETVMYPAYAKWVQ

EPRS1

1121

P07814
LVIYVSWKRYPASMK

LRRTM3

436

Q86VH5
WMPYISIVCVISYVI

SLC2A5

371

P22732
VIYQMPSTAISWSVY

SLC25A37

306

Q9NYZ2
IWSYTYLEKSVMLLL

TENM1

1881

Q9UKZ4
VQYEILKAIAYWMTI

TENM1

2111

Q9UKZ4
DKWASVFYTVIIPML

OR5AR1

271

Q8NGP9
YITMTYTRIPQVPWT

CMTM8

91

Q8IZV2
PVATWNIYRYIMVPS

CNIH4

76

Q9P003
YPKRTDVWSVYIDMT

PDCD11

1791

Q14690
EKYIPVLMAQAKIYW

TTC30B

421

Q8N4P2
HVMLYVVPIYLLWKG

TMEM164

181

Q5U3C3
VAWILATSKVFMYPE

YY1AP1

271

Q9H869
AFSPESLFYVVWKIM

USP3

236

Q9Y6I4
VEIMTYVTWKLSTFP

UEVLD

296

Q8IX04
EKYIPVLMAQAKIYW

TTC30A

421

Q86WT1
WLVVAYTMLVLIAVY

PIEZO1

631

Q92508
AYYKQWLTVMPAEET

PTCD1

656

O75127
MPIKHAIQWLYPYSI

VWA8

331

A3KMH1