Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hydroxyacylglutathione hydrolase activity	HAGHL PNKD	4.51e-05	3	78	2	GO:0004416
Domain	Peptidase_M43	PAPPA2 PAPPA	1.63e-05	2	76	2	IPR008754
Domain	Peptidase_M43	PAPPA2 PAPPA	1.63e-05	2	76	2	PF05572
Domain	FERM_central	PLEKHH1 JAK1 JAK2 PTPN14	4.67e-05	49	76	4	IPR019748
Domain	FERM_domain	PLEKHH1 JAK1 JAK2 PTPN14	4.67e-05	49	76	4	IPR000299
Domain	Myxo_disulph_rpt	PAPPA2 PAPPA	4.89e-05	3	76	2	IPR011936
Domain	Pex2_Pex12	PEX2 PEX12	4.89e-05	3	76	2	PF04757
Domain	Pex_N	PEX2 PEX12	4.89e-05	3	76	2	IPR006845
Domain	FERM_1	PLEKHH1 JAK1 JAK2 PTPN14	5.06e-05	50	76	4	PS00660
Domain	FERM_2	PLEKHH1 JAK1 JAK2 PTPN14	5.06e-05	50	76	4	PS00661
Domain	FERM_3	PLEKHH1 JAK1 JAK2 PTPN14	5.06e-05	50	76	4	PS50057
Domain	Band_41_domain	PLEKHH1 JAK1 JAK2 PTPN14	5.06e-05	50	76	4	IPR019749
Domain	B41	PLEKHH1 JAK1 JAK2 PTPN14	5.06e-05	50	76	4	SM00295
Domain	LamGL	PAPPA2 PAPPA	9.75e-05	4	76	2	SM00560
Domain	Tyr_kinase_non-rcpt_Jak/Tyk2	JAK1 JAK2	9.75e-05	4	76	2	IPR016251
Domain	LamG-like	PAPPA2 PAPPA	9.75e-05	4	76	2	IPR006558
Domain	Ig-like_fold	SEMA3A PAPPA2 ANTXRL FLNA FLT4 HLA-DQB1 OSCAR HLA-H NXPE1 ZPBP2 LRRN4	1.27e-04	706	76	11	IPR013783
Domain	Notch_dom	PAPPA2 PAPPA	3.39e-04	7	76	2	IPR000800
Domain	Notch	PAPPA2 PAPPA	3.39e-04	7	76	2	PF00066
Domain	NL	PAPPA2 PAPPA	3.39e-04	7	76	2	SM00004
Domain	-	SEMA3A PAPPA2 ANTXRL FLNA FLT4 HLA-DQB1 OSCAR NXPE1 ZPBP2 LRRN4	3.43e-04	663	76	10	2.60.40.10
Domain	Lactamase_B	HAGHL PNKD	1.24e-03	13	76	2	PF00753
Domain	Lactamase_B	HAGHL PNKD	1.66e-03	15	76	2	SM00849
Domain	-	HAGHL PNKD	2.96e-03	20	76	2	3.60.15.10
Domain	Metallo-B-lactamas	HAGHL PNKD	2.96e-03	20	76	2	IPR001279
Domain	MetalloPept_cat_dom	PAPPA2 ADAMTS9 PAPPA	4.40e-03	81	76	3	IPR024079
Domain	-	PAPPA2 ADAMTS9 PAPPA	4.40e-03	81	76	3	3.40.390.10
Domain	TyrKc	JAK1 JAK2 FLT4	5.55e-03	88	76	3	SM00219
Domain	Tyr_kinase_cat_dom	JAK1 JAK2 FLT4	5.55e-03	88	76	3	IPR020635
Domain	PROTEIN_KINASE_TYR	JAK1 JAK2 FLT4	7.26e-03	97	76	3	PS00109
Domain	Tyr_kinase_AS	JAK1 JAK2 FLT4	7.26e-03	97	76	3	IPR008266
Domain	ZINC_PROTEASE	PAPPA2 ADAMTS9 PAPPA	7.47e-03	98	76	3	PS00142
Domain	PH_dom-like	ROCK2 PLEKHH1 JAK1 JAK2 PTPN14 OSBPL11	7.76e-03	426	76	6	IPR011993
Pubmed	Anti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for JAK/STAT pathway inhibition in myeloma patients.	JAK1 JAK2	4.97e-06	2	78	2	28645562
Pubmed	Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation.	JAK1 JAK2	4.97e-06	2	78	2	24169825
Pubmed	Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans.	FLT4 PTPN14	4.97e-06	2	78	2	20826270
Pubmed	Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice.	PAPPA2 PAPPA	4.97e-06	2	78	2	21586553
Pubmed	Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors.	JAK1 JAK2	4.97e-06	2	78	2	21393331
Pubmed	Pharmacologic Inhibition of JAK1/JAK2 Signaling Reduces Experimental Murine Acute GVHD While Preserving GVT Effects.	JAK1 JAK2	4.97e-06	2	78	2	25977345
Pubmed	The Janus kinases inhibitor AZD1480 attenuates growth of small cell lung cancers in vitro and in vivo.	JAK1 JAK2	4.97e-06	2	78	2	24158701
Pubmed	SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.	JAK1 JAK2	4.97e-06	2	78	2	33827897
Pubmed	Identifying novel risk conferring genes involved in glycosylation processes with familial schizophrenia in an Indian cohort: Prediction of ADAMTS9 gene variant for structural stability.	PIGQ ADAMTS9	4.97e-06	2	78	2	37105505
Pubmed	Ruxolitinib + capecitabine in advanced/metastatic pancreatic cancer after disease progression/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies.	JAK1 JAK2	4.97e-06	2	78	2	29508247
Pubmed	Therapeutic effect of JAK1/2 blockade on the manifestations of hemophagocytic lymphohistiocytosis in mice.	JAK1 JAK2	4.97e-06	2	78	2	27222478
Pubmed	Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.	JAK1 JAK2	4.97e-06	2	78	2	27903500
Pubmed	Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24.	JAK1 JAK2	4.97e-06	2	78	2	1581631
Pubmed	Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin.	PAPPA2 PAPPA	4.97e-06	2	78	2	11513734
Pubmed	Combined inhibition of Janus kinase 1/2 for the treatment of JAK2V617F-driven neoplasms: selective effects on mutant cells and improvements in measures of disease severity.	JAK1 JAK2	4.97e-06	2	78	2	19887489
Pubmed	Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2.	JAK1 JAK2	4.97e-06	2	78	2	35382859
Pubmed	Pregnancy associated plasma protein-A as a prognostic biomarker of all-cause mortality and cardiovascular events in patients presenting with chest pain: a systematic review.	PAPPA2 PAPPA	4.97e-06	2	78	2	29144175
Pubmed	Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells.	JAK1 JAK2	4.97e-06	2	78	2	22684105
Pubmed	Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.	JAK1 JAK2	4.97e-06	2	78	2	1848670
Pubmed	Sema3A inhibits axonal regeneration of retinal ganglion cells via ROCK2.	SEMA3A ROCK2	4.97e-06	2	78	2	31733191
Pubmed	Preclinical evaluation of JAK1/2 inhibition by ruxolitinib in a murine model of chronic graft-versus-host disease.	JAK1 JAK2	4.97e-06	2	78	2	33811972
Pubmed	Long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis.	JAK1 JAK2	4.97e-06	2	78	2	29263442
Pubmed	Frequency and prognostic implications of JAK 1-3 aberrations in Down syndrome acute lymphoblastic and myeloid leukemia.	JAK1 JAK2	1.49e-05	3	78	2	21537335
Pubmed	Progesterone activates Janus Kinase 1/2 and activators of transcription 1 (JAK1-2/STAT1) pathway in human spermatozoa.	JAK1 JAK2	1.49e-05	3	78	2	22748021
Pubmed	Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.	JAK1 JAK2	1.49e-05	3	78	2	17550976
Pubmed	Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.	JAK1 JAK2	1.49e-05	3	78	2	9548458
Pubmed	Structural organization and chromosomal mapping of JAK3 locus.	JAK1 JAK2	1.49e-05	3	78	2	8934548
Pubmed	The peroxisomal membrane targeting elements of human peroxin 2 (PEX2).	PEX2 PEX12	1.49e-05	3	78	2	12751901
Pubmed	Foot-and-mouth disease virus structural protein VP3 degrades Janus kinase 1 to inhibit IFN-γ signal transduction pathways.	JAK1 JAK2	1.49e-05	3	78	2	26901336
Pubmed	Induction of Jak/STAT signaling by activation of the type 1 TNF receptor.	JAK1 JAK2	1.49e-05	3	78	2	9510175
Pubmed	Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway.	ROCK2 CHORDC1	1.49e-05	3	78	2	24615293
Pubmed	Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function.	JAK1 JAK2	1.49e-05	3	78	2	20128689
Pubmed	Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro.	JAK1 JAK2	1.49e-05	3	78	2	27383175
Pubmed	Age-associated inflammation inhibits epidermal stem cell function.	JAK1 JAK2	1.49e-05	3	78	2	22972935
Pubmed	Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children.	JAK1 JAK2	1.49e-05	3	78	2	27554814
Pubmed	LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease.	JAK1 JAK2	1.49e-05	3	78	2	21151131
Pubmed	A preliminary study of new single polymorphisms in the T helper type 17 pathway for psoriasis in the Korean population.	JAK1 JAK2	1.49e-05	3	78	2	27774581
Pubmed	Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.	JAK1 JAK2	1.49e-05	3	78	2	8272873
Pubmed	The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes.	JAK1 JAK2	1.49e-05	3	78	2	29162613
Pubmed	Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.	JAK1 JAK2	1.49e-05	3	78	2	8378315
Pubmed	Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.	ROCK2 CHORDC1	1.49e-05	3	78	2	20230755
Pubmed	INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support.	JAK1 JAK2	1.49e-05	3	78	2	20072651
Pubmed	YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.	JAK1 JAK2	1.49e-05	3	78	2	12551917
Pubmed	Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells.	JAK1 JAK2	1.49e-05	3	78	2	15923602
Pubmed	Piperlongumine inhibits gastric cancer cells via suppression of the JAK1,2/STAT3 signaling pathway.	JAK1 JAK2	1.49e-05	3	78	2	27053336
Pubmed	Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients.	PAPPA2 PAPPA	1.49e-05	3	78	2	18805800
Pubmed	CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.	JAK1 JAK2	1.49e-05	3	78	2	26175413
Pubmed	Janus kinases 1 and 2 regulate chemokine-mediated integrin activation and naïve T-cell homing.	JAK1 JAK2	1.49e-05	3	78	2	23526587
Pubmed	ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells.	ROCK2 JAK2	1.49e-05	3	78	2	30413785
Pubmed	Jak3 maps to chromosome 8.	JAK1 JAK2	1.49e-05	3	78	2	8662243
Pubmed	Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR.	PAPPA2 PAPPA	1.49e-05	3	78	2	29532882
Pubmed	Involvement of JAK1, JAK2, and JAK3 in Stimulation of Functional Activity of Mesenchymal Progenitor Cells by Fibroblast Growth Factor.	JAK1 JAK2	1.49e-05	3	78	2	27905037
Pubmed	Altered placental expression of PAPPA2 does not affect birth weight in mice.	PAPPA2 PAPPA	1.49e-05	3	78	2	20642865
Pubmed	Three lysine residues in the common β chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling.	JAK1 JAK2	1.49e-05	3	78	2	21965659
Pubmed	Reelin is required for class-specific retinogeniculate targeting.	RELN OPN4	1.49e-05	3	78	2	21228166
Pubmed	JAK mutations in high-risk childhood acute lymphoblastic leukemia.	JAK1 JAK2	1.49e-05	3	78	2	19470474
Pubmed	A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.	PEX2 PEX12	1.49e-05	3	78	2	35768507
Pubmed	Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130.	JAK1 JAK2	1.49e-05	3	78	2	10586060
Pubmed	The Janus kinase family of protein tyrosine kinases and their role in signaling.	JAK1 JAK2	1.49e-05	3	78	2	10526570
Pubmed	Amorfrutin A inhibits TNF-α induced JAK/STAT signaling, cell survival and proliferation of human cancer cells.	JAK1 JAK2	1.49e-05	3	78	2	28879797
Pubmed	Protein tyrosine phosphorylation as a mechanism which regulates cytokine activation of early response genes.	JAK1 JAK2	1.49e-05	3	78	2	7539296
Pubmed	Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs.	JAK1 JAK2	1.49e-05	3	78	2	32001089
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	JAK1 JAK2 PTPRA	2.41e-05	25	78	3	8493579
Pubmed	Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.	ROCK2 FLNA RELN	2.72e-05	26	78	3	17875933
Pubmed	Dipyrithione inhibits IFN-gamma-induced JAK/STAT1 signaling pathway activation and IP-10/CXCL10 expression in RAW264.7 cells.	JAK1 JAK2	2.97e-05	4	78	2	20372968
Pubmed	Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.	JAK1 JAK2	2.97e-05	4	78	2	20139093
Pubmed	Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells.	JAK1 JAK2	2.97e-05	4	78	2	15988755
Pubmed	Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases.	JAK1 JAK2	2.97e-05	4	78	2	8995399
Pubmed	MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR.	FLNA TSC1	2.97e-05	4	78	2	25277454
Pubmed	Loss of JAK1 Drives Innate Immune Deficiency.	JAK1 JAK2	2.97e-05	4	78	2	30671064
Pubmed	Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases.	JAK1 JAK2	2.97e-05	4	78	2	9452495
Pubmed	Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins.	JAK1 JAK2	2.97e-05	4	78	2	8657151
Pubmed	Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation.	JAK1 JAK2	2.97e-05	4	78	2	18430728
Pubmed	Involvement of Janus kinases in the insulin signaling pathway.	JAK1 JAK2	2.97e-05	4	78	2	8536716
Pubmed	Regulation of the Jak/STAT signalling pathway.	JAK1 JAK2	2.97e-05	4	78	2	8593242
Pubmed	Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.	JAK1 JAK2	2.97e-05	4	78	2	24843152
Pubmed	Tumoricidal effects of the JAK inhibitor Ruxolitinib (INC424) on hepatocellular carcinoma in vitro.	JAK1 JAK2	2.97e-05	4	78	2	23941832
Pubmed	Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families.	SEMA3A RELN	2.97e-05	4	78	2	17684500
Pubmed	Three distinct signalling responses by murine fibroblasts to genotoxic stress.	JAK1 JAK2	2.97e-05	4	78	2	8918879
Pubmed	Interferon-γ stimulates human follicular dendritic cell-like cells to produce prostaglandins via the JAK-STAT pathway.	JAK1 JAK2	2.97e-05	4	78	2	25818476
Pubmed	Involvement of JAK/STAT (Janus kinase/signal transducer and activator of transcription) in the thyrotropin signaling pathway.	JAK1 JAK2	2.97e-05	4	78	2	10809230
Pubmed	Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells.	JAK1 JAK2	2.97e-05	4	78	2	11163768
Pubmed	JAK pathway induction of c-Myc critical to IL-5 stimulation of cell proliferation and inhibition of apoptosis.	JAK1 JAK2	2.97e-05	4	78	2	19180571
Pubmed	Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells.	JAK1 JAK2	2.97e-05	4	78	2	19361784
Pubmed	Inhibiton of RET and JAK2 signals and upregulation of VEGFR3 phosphorylation in vitro by galectin-1 in trophoblast tumor cells BeWo.	JAK2 FLT4	2.97e-05	4	78	2	19900702
Pubmed	CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.	JAK1 JAK2	2.97e-05	4	78	2	11201744
Pubmed	Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.	JAK1 JAK2	2.97e-05	4	78	2	28965767
Pubmed	Distinct modes of ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulate PTS1 protein import.	PEX2 PEX12	2.97e-05	4	78	2	24662292
Pubmed	Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.	JAK1 JAK2	2.97e-05	4	78	2	8041779
Pubmed	The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities.	JAK1 JAK2	2.97e-05	4	78	2	15659653
Pubmed	CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy.	JAK1 JAK2	2.97e-05	4	78	2	28278176
Pubmed	Molecular pathways: Jak/STAT pathway: mutations, inhibitors, and resistance.	JAK1 JAK2	2.97e-05	4	78	2	23406773
Pubmed	Cytokine receptor-like factor 1 (CRLF1) protects against 6-hydroxydopamine toxicity independent of the gp130/JAK signaling pathway.	JAK1 JAK2	2.97e-05	4	78	2	23818941
Pubmed	JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation.	JAK1 JAK2	2.97e-05	4	78	2	9516124
Pubmed	Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.	JAK1 JAK2	2.97e-05	4	78	2	9553136
Pubmed	IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis.	JAK1 JAK2	2.97e-05	4	78	2	22226123
Pubmed	The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver.	JAK1 JAK2	2.97e-05	4	78	2	10502458
Pubmed	STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction.	JAK1 JAK2	2.97e-05	4	78	2	9133424
Pubmed	The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue.	ROCK2 PLEKHH1 ZBTB41 DYNC1I1	3.10e-05	79	78	4	25921334
Pubmed	Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p.	PEX2 PEX12	4.94e-05	5	78	2	10837480
Cytoband	1p32.3-p31.3	JAK1 ANKRD13C	2.85e-06	2	78	2	1p32.3-p31.3
Cytoband	3p21.3	P4HTM VILL DLEC1	1.43e-04	59	78	3	3p21.3
GeneFamily	Pappalysins\|Sushi domain containing	PAPPA2 PAPPA	8.76e-06	2	54	2	897
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PLEKHH1 JAK1 JAK2 PTPN14	1.48e-05	50	54	4	1293
GeneFamily	AAA ATPases\|Peroxins	PEX2 PEX12	1.02e-03	16	54	2	957
GeneFamily	Immunoglobulin like domain containing	SEMA3A FLT4 OSCAR ZPBP2	2.62e-03	193	54	4	594
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3A RELN FLT4 PTPN14 ADAMTS9 FZD10 DYNC1I1	5.25e-08	195	78	7	590c0dc0db4dc62879645ed7f61292ff97d2c7d5
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	SEMA3A RELN FLT4 PTPN14 ADAMTS9 DYNC1I1	8.95e-07	185	78	6	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	SEMA3A RELN FLT4 PTPN14 ADAMTS9 DYNC1I1	8.95e-07	185	78	6	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SEMA3A RELN FLT4 PTPN14 ADAMTS9 DYNC1I1	9.83e-07	188	78	6	aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell	Transplant_Alveoli_and_parenchyma-Endothelial-Lymphatic\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	SEMA3A RELN FLT4 PTPN14 ADAMTS9 FZD10	1.05e-06	190	78	6	8d6ec2fc0af19a5cb16fff34f8b131b71b33d45f
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SEMA3A RELN FLT4 PTPN14 ADAMTS9 DYNC1I1	1.05e-06	190	78	6	6e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel\|Adult / Lineage, Cell type, age group and donor	SEMA3A RELN FLT4 PTPN14 ADAMTS9 DYNC1I1	1.05e-06	190	78	6	91bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A RELN FLT4 CHSY3 DYNC1I1	1.03e-05	164	78	5	a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A RELN FLT4 CHSY3 DYNC1I1	1.03e-05	164	78	5	1a1795969673232191425dde84ab24ee6a98143f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A RELN FLT4 CHSY3 DYNC1I1	1.03e-05	164	78	5	8f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCell	Endothelial-B-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	SEMA3A RELN FLT4 PTPN14 FZD10	1.06e-05	165	78	5	b6893882472aeb0d18e26f47eaec9d53688afcde
ToppCell	Endothelial-B-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	SEMA3A RELN FLT4 FZD10 DYNC1I1	1.19e-05	169	78	5	8889c9e8af1ab0b093d57b69abd80b59b3461be9
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3A RELN FLT4 PTPN14 KCNN1	1.26e-05	171	78	5	686f95892c3909973c66c9a27159a070a068f175
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3A RELN FLT4 PTPN14 KCNN1	1.26e-05	171	78	5	f7ba03e7bdb687f93782c936c7b3374cc5b3b77c
ToppCell	PND14-Endothelial-Endothelial_lymphatic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3A RELN FLT4 PTPN14 KCNN1	1.26e-05	171	78	5	d0ac50071a3854d02113c455fcc940a6ec59bbb9
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA3A RELN FLT4 PTPN14 KCNN1	1.26e-05	171	78	5	fbf8e9db00573adcada4b25730e191417b7c9999
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FLT4 PTPN14 SHMT1 FZD10	1.30e-05	172	78	5	b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCell	facs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN FLT4 PTPN14 SHMT1 FZD10	1.30e-05	172	78	5	2f1673fcb2356684d60871debb0f159aec553a1c
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D122\|Adult / Lineage, Cell type, age group and donor	SEMA3A RELN FLT4 ADAMTS9 DYNC1I1	1.33e-05	173	78	5	dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCell	Endothelial-B-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	SEMA3A RELN FLT4 FZD10 DYNC1I1	1.33e-05	173	78	5	a81992965137195d20fc498f750975303961a828
ToppCell	Control-Neuronal_cells-Neuronal_cells\|Control / group, cell type (main and fine annotations)	SEMA3A RELN FLT4 ADAMTS9 DYNC1I1	1.45e-05	176	78	5	98c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCell	Control-Neuronal_cells\|Control / group, cell type (main and fine annotations)	SEMA3A RELN FLT4 ADAMTS9 DYNC1I1	1.45e-05	176	78	5	c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D231\|Adult / Lineage, Cell type, age group and donor	SEMA3A RELN FLT4 ADAMTS9 DYNC1I1	1.53e-05	178	78	5	c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SEMA3A RELN FLT4 PTPN14 FZD10	1.66e-05	181	78	5	b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)\|367C / Donor, Lineage, Cell class and subclass (all cells)	SEMA3A RELN FLT4 PTPN14 FZD10	1.66e-05	181	78	5	dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A RELN FLT4 BMP2K CHSY3	1.70e-05	182	78	5	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A RELN FLT4 BMP2K CHSY3	1.70e-05	182	78	5	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A RELN FLT4 BMP2K CHSY3	1.70e-05	182	78	5	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	Endothelial-B-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	SEMA3A RELN FLT4 ADAMTS9 FZD10	1.84e-05	185	78	5	133c9dc64d564dae4aeeeca22f386aa3f13fa980
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D175\|Adult / Lineage, Cell type, age group and donor	SEMA3A RELN FLT4 PTPN14 ADAMTS9	1.94e-05	187	78	5	1e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCell	Endothelial-endothelial_cell_of_lymph_vessel\|World / Lineage, Cell type, age group and donor	SEMA3A RELN FLT4 PTPN14 ADAMTS9	1.99e-05	188	78	5	80910dcbb51990f2baed240f319456c0d3fa2065
ToppCell	Endothelial-B\|World / lung cells shred on cell class, cell subclass, sample id	SEMA3A RELN FLT4 PTPN14 FZD10	1.99e-05	188	78	5	5959a88728812a5f4cbfa54eddc7a73ccbaa2f68
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SEMA3A RELN FLT4 PTPN14 DYNC1I1	1.99e-05	188	78	5	c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCell	Endothelial-B-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	SEMA3A RELN FLT4 PEX12 WDR76	1.99e-05	188	78	5	ecb74d67314a43b5805b7f2a7bb9ff6c5a60200a
ToppCell	COVID-19-lung-Lymphatic_EC\|lung / Disease (COVID-19 only), tissue and cell type	SEMA3A RELN FLT4 ADAMTS9 DYNC1I1	2.04e-05	189	78	5	c8db9aaf54ea3cc96c4a2f777c3389e0f31f67f3
ToppCell	5'-Adult-Appendix-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA ADAMTS9 MYOCD CACNA1H DYNC1I1	2.04e-05	189	78	5	0daa8efac08dca9525d2b8d421952068cab4eb50
ToppCell	Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	FLNA OSCAR OSBPL11 ITGAL NCKAP1L	2.04e-05	189	78	5	c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCell	5'-Adult-Appendix-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA ADAMTS9 MYOCD CACNA1H DYNC1I1	2.04e-05	189	78	5	b6bb4327b4560d07d2b728abcc5f144f428948a5
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SEMA3A RELN FLT4 PTPN14 ADAMTS9	2.20e-05	192	78	5	291df12b4b5ff11fbaa43033692b8f4b5cdf65a1
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SEMA3A RELN FLT4 PTPN14 ADAMTS9	2.20e-05	192	78	5	35ffe7aa9ffab85eac3326651e901c39d0119650
ToppCell	COPD-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	SEMA3A RELN FLT4 ADAMTS9 DYNC1I1	2.26e-05	193	78	5	25bdc557055b5bce6a21f8696b48e991c696b979
ToppCell	LAM-Endothelial-LymEndo\|LAM / Condition, Lineage and Cell class	SEMA3A RELN FLT4 PTPN14 ADAMTS9	2.26e-05	193	78	5	68eadc91c2d89edd2412e86dfe134dd7c0ef6ee9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BMP2K HLA-DQB1 OSCAR ITGAL NCKAP1L	2.26e-05	193	78	5	3e3d7cb3e7242ec9c9677e07e303835649852b52
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SEMA3A RELN FLT4 PTPN14 ADAMTS9	2.26e-05	193	78	5	040f6bb42aa41d0921371fdda1cc0912c4fe1930
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SEMA3A RELN FLT4 PTPN14 ADAMTS9	2.26e-05	193	78	5	e468287c8b30c56d1de65e8347ade233ba6cf584
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic-LEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SEMA3A RELN FLT4 ADAMTS9 DYNC1I1	2.32e-05	194	78	5	f772a9f9ef8635aeaeb8b022dbb94e9672b36ead
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3A RELN FLT4 ADAMTS9 FZD10	2.32e-05	194	78	5	937ee85ffd50869b60f0f6e91017ab77e8b24c0b
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic-LEC-LEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SEMA3A RELN FLT4 ADAMTS9 DYNC1I1	2.32e-05	194	78	5	3b73f2d305a7566f7ab567e5f18c82cd3d80e32c
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SEMA3A RELN FLT4 ADAMTS9 DYNC1I1	2.32e-05	194	78	5	5d2b3ed5374e2ab10c1c7eb3a03139fc95036a48
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3A RELN FLT4 ADAMTS9 FZD10	2.37e-05	195	78	5	36d4a11bc77a4cc97a22525c78ef8359f4a3ca66
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA ADAMTS9 MYOCD CACNA1H DYNC1I1	2.43e-05	196	78	5	ce6f7ddb8104471dc90347f427486379914d63b4
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-Pericytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA ADAMTS9 MYOCD CACNA1H DYNC1I1	2.43e-05	196	78	5	6d7179decea512dd49bb2d5f6a4f5989349d52a9
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA ADAMTS9 MYOCD CACNA1H DYNC1I1	2.49e-05	197	78	5	d16bb765afdc02406ffd7ce6a75bae72b66db66c
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3A RELN FLT4 PTPN14 FZD10	2.49e-05	197	78	5	407231542fa1ffd540dcb61435c0575e71f59725
ToppCell	distal-1-Endothelial-Lymphatic\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SEMA3A RELN FLT4 PTPN14 ADAMTS9	2.55e-05	198	78	5	b6fea363463c8dd7e6780c085ece4900266a6286
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FLNA ADAMTS9 MYOCD CACNA1H DYNC1I1	2.55e-05	198	78	5	7dd874b09c81cc512ccc1e9b65f290a5f94d736e
ToppCell	Fetal_29-31_weeks-Immune\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BMP2K HLA-DQB1 OSCAR ITGAL NCKAP1L	2.55e-05	198	78	5	5dff131356b8c22743bd27b2b21f86ee6e4a0a0d
ToppCell	5'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3A RELN FLT4 PTPN14 ADAMTS9	2.55e-05	198	78	5	90e85fe7a0ab376a41666dfff6c0e95b7f1c9475
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FLNA SACS ADAMTS9 MYOCD CACNA1H	2.68e-05	200	78	5	a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3A RELN FLT4 PTPN14 DYNC1I1	2.68e-05	200	78	5	c59f262b2b0a7e7dcb2940d1e466f98db6c56625
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3A RELN FLT4 PTPN14 DYNC1I1	2.68e-05	200	78	5	e50ef394e3284a8323bfd60575b262b2be422aea
ToppCell	COVID-19-kidney-Epithelial_(EC)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SEMA3A FLT4 PCDH11Y FBN3	8.79e-05	133	78	4	a8abb6b54862123961ae6defbf251ee6e9575258
ToppCell	LPS_only-Lymphocytic_NKT-iNKT/MAIT-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HAGHL SHMT1 ITGAL ENOX2	1.43e-04	151	78	4	7270b8bbfae659e110bd9d513b602120b25de3dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A RELN FLT4 CHSY3	1.83e-04	161	78	4	fb59d96c2aa9e4654f02bf6ce36bf832776cb4dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A RELN FLT4 CHSY3	1.83e-04	161	78	4	c53c461fc721a7960cef86662f49e2a495520701
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A RELN FLT4 CHSY3	1.88e-04	162	78	4	2ac02523348660e514d464f8f2434ee0c312d784
ToppCell	droplet-Lung-nan-18m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN OOSP1 CACNA1H ZPBP2	1.92e-04	163	78	4	5efecdd8a069a822bc9d35b407092925a865e629
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ROCK2 KCNN1 LRRN4 ITGAL	1.92e-04	163	78	4	218b9ba099cb27aa91c6b73bf89b44895f5dddc3
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN OOSP1 CACNA1H ZPBP2	1.92e-04	163	78	4	0d94a427f86e62aba12c397c6d7b8cd297f3a0e5
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN FLT4 PTPN14 PAPPA	1.97e-04	164	78	4	4cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN FLT4 PTPN14 PAPPA	1.97e-04	164	78	4	7a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCell	PND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN FLT4 PTPN14 PAPPA	1.97e-04	164	78	4	5e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCell	PND10-Endothelial-Endothelial_lymphatic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN FLT4 PTPN14 PAPPA	1.97e-04	164	78	4	f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN FLT4 NIM1K FZD10	2.01e-04	165	78	4	347b59aa625a8a960828b8620824d8ac48990e07
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A SPIRE2 SLC44A5 CHSY3	2.01e-04	165	78	4	1b7dfa173e83aa8c46a3153a3261866c065c3b73
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN FLT4 NIM1K FZD10	2.01e-04	165	78	4	507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN FLT4 NIM1K FZD10	2.01e-04	165	78	4	39a25be081a5d59c7cf107a997d352793d5025fb
ToppCell	PND03-Endothelial-Endothelial_lymphatic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN FLT4 NIM1K FZD10	2.01e-04	165	78	4	1890f9c33b0c5b381d57f97042da2610a093a6de
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3A SPIRE2 SLC44A5 CHSY3	2.01e-04	165	78	4	b4f7d33af7d053ec07b01bd67d861600a9c4822e
ToppCell	droplet-Thymus-nan-21m-Myeloid-Plasma_cells_and_B_cells\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN OOSP1 CACNA1H DLEC1	2.01e-04	165	78	4	21a82a975f550080b6674750b06212205cd16742
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FLNA PAPPA MYOCD CACNA1H	2.01e-04	165	78	4	8a82e20c9b1156bb4bbc16f7785abb04458d671b
ToppCell	facs-Marrow-B-cells-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN OOSP1 OSCAR CACNA1H	2.01e-04	165	78	4	361a605d8f833d9ec54b120480dce397da35f9c3
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF547 NOL6 PRPF19 DLEC1	2.06e-04	166	78	4	ceb0a48c0d853448fd45ac31dde046df9a178571
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	SEMA3A RELN FLT4 ADAMTS9	2.06e-04	166	78	4	5ba45407a47207ff01e4a3f9f5d91d8247fe9b6f
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)\|356C / Donor, Lineage, Cell class and subclass (all cells)	SEMA3A RELN FLT4 ADAMTS9	2.06e-04	166	78	4	6bd5aa205b6e4b88ba9f8cd0999e2191d7d1d16c
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma-7\|TCGA-Kidney / Sample_Type by Project: Shred V9	RELN P4HTM DLEC1 LRRN4	2.06e-04	166	78	4	b545de32578047c9ca422354b8992f2d9c9e1cc7
ToppCell	Endothelial-B-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	RELN FLT4 PTPN14 ADAMTS9	2.11e-04	167	78	4	6a03d16165e0b003092c39972928981abd4a75aa
ToppCell	COVID-19-kidney-Lymphatic_EC\|kidney / Disease (COVID-19 only), tissue and cell type	SEMA3A RELN FLT4 CHSY3	2.11e-04	167	78	4	97d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HLA-DQB1 OSCAR ITGAL NCKAP1L	2.16e-04	168	78	4	907692c1f03d3c9889ba1bed5a4844e2c379db8e
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)\|368C / Donor, Lineage, Cell class and subclass (all cells)	SEMA3A RELN FLT4 FZD10	2.16e-04	168	78	4	a74c8a9e3299183fba31ce3053ef325b5dbcd104
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	SEMA3A RELN FLT4 FZD10	2.16e-04	168	78	4	dae37b316ce80dfe4236c4ed7f0d4e7c340fa7b6
ToppCell	Endothelial-B-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	SEMA3A RELN FLT4 PTPN14	2.16e-04	168	78	4	4977c3837fbb1f36c89fddd5764e37290ac25ad8
ToppCell	Endothelial-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	SEMA3A RELN FLT4 FZD10	2.21e-04	169	78	4	95c617143e1fbdd1d55a93ffdcc210e0be37cf2f
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 SAT1 ITGAL NCKAP1L	2.21e-04	169	78	4	0f5e737b265ba333275a0cd289dab029a1542075
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A RELN FLT4 CHSY3	2.26e-04	170	78	4	6035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A RELN FLT4 CHSY3	2.26e-04	170	78	4	c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SACS TP53I13 PRPF19 ENOX2	2.26e-04	170	78	4	32917888c3f1d54302675c1d4de1fd3b7c79af5f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3A RELN FLT4 CHSY3	2.26e-04	170	78	4	dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCell	ASK454-Immune-NK_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	JAK1 RELN CHORDC1 ITGAL	2.26e-04	170	78	4	84705434234bf2fbb5256bd5a1f6ab54c01c5a51
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3A RELN FLT4 PTPN14	2.26e-04	170	78	4	4848965bc7e9356c6601bb41eeea1553d2eea87e
Computational	Neighborhood of SNRK	JAK1 ITGAL HECA	1.82e-04	28	43	3	GNF2_SNRK
Disease	PEROXISOME BIOGENESIS DISORDER 3B	PEX2 PEX12	6.51e-05	5	76	2	C3550693
Disease	nitric oxide exhalation measurement	PAPPA2 ZPBP2 DLEC1	1.30e-04	38	76	3	EFO_0005536
Disease	disease of cellular proliferation (implicated_via_orthology)	JAK1 JAK2	1.36e-04	7	76	2	DOID:14566 (implicated_via_orthology)
Disease	Polycythemia Vera	JAK1 JAK2	1.81e-04	8	76	2	C0032463
Disease	age-related hearing impairment	SPIRE2 PTPN14 HLA-DQB1 FZD10 DLEC1 DYNC1I1	1.92e-04	324	76	6	EFO_0005782
Disease	ulcerative colitis	JAK2 HLA-DQB1 NXPE1 ZPBP2 CHORDC1 PNKD	2.30e-04	335	76	6	EFO_0000729
Disease	oropharynx cancer	JAK2 HLA-DQB1 HLA-H	2.30e-04	46	76	3	EFO_1001931
Disease	PEROXISOME BIOGENESIS DISORDER 1A (ZELLWEGER)	PEX2 PEX12	3.55e-04	11	76	2	C4721541
Disease	Zellweger Spectrum	PEX2 PEX12	5.01e-04	13	76	2	C3658299
Disease	hematologic cancer (implicated_via_orthology)	JAK1 JAK2	5.01e-04	13	76	2	DOID:2531 (implicated_via_orthology)
Disease	Infantile Refsum Disease (disorder)	PEX2 PEX12	5.01e-04	13	76	2	C0282527
Disease	Zellweger-Like Syndrome	PEX2 PEX12	5.01e-04	13	76	2	C0751594
Disease	Peroxisome biogenesis disorders	PEX2 PEX12	6.73e-04	15	76	2	C1832200
Disease	Adrenoleukodystrophy, Neonatal	PEX2 PEX12	6.73e-04	15	76	2	C0282525
Disease	Zellweger Syndrome	PEX2 PEX12	7.67e-04	16	76	2	C0043459
Disease	ulcerative colitis (is_implicated_in)	JAK2 HLA-DQB1	8.68e-04	17	76	2	DOID:8577 (is_implicated_in)
Disease	Familial Progressive Myoclonic Epilepsy	SACS TSC1	8.68e-04	17	76	2	C0751777
Disease	Atypical Inclusion-Body Disease	SACS TSC1	8.68e-04	17	76	2	C0751776
Disease	Myoclonic Epilepsies, Progressive	SACS TSC1	8.68e-04	17	76	2	C0751778
Disease	Biotin-Responsive Encephalopathy	SACS TSC1	8.68e-04	17	76	2	C0751780
Disease	May-White Syndrome	SACS TSC1	8.68e-04	17	76	2	C0751782
Disease	Dentatorubral-Pallidoluysian Atrophy	SACS TSC1	8.68e-04	17	76	2	C0751781
Disease	Action Myoclonus-Renal Failure Syndrome	SACS TSC1	9.75e-04	18	76	2	C0751779
Disease	ankylosing spondylitis (is_implicated_in)	JAK2 HLA-DQB1	1.09e-03	19	76	2	DOID:7147 (is_implicated_in)
Disease	acute myeloid leukemia (is_implicated_in)	JAK2 HLA-DQB1 DLEC1	1.35e-03	84	76	3	DOID:9119 (is_implicated_in)
Disease	reticulocyte measurement	PIGQ FLNA SPIRE2 PTPRA BMP2K HLA-DQB1 HLA-H PEX12 PNKD	1.52e-03	1053	76	9	EFO_0010700
Disease	basophil count	JAK2 HLA-DQB1 HLA-H CHORDC1 PNKD HECA	1.55e-03	483	76	6	EFO_0005090
Disease	peak expiratory flow	PAPPA2 HLA-DQB1 ZNF76 DLEC1 ASB14 FBN3	1.81e-03	498	76	6	EFO_0009718
Disease	neuroblastoma, cutaneous melanoma	SPIRE2 NOL6	2.37e-03	28	76	2	EFO_0000389, EFO_0000621
Disease	complement factor H-related protein 2 measurement	ZBTB41 DYNC1I1	2.54e-03	29	76	2	EFO_0600055

Protein segments in the cluster

Peptide	Gene	Start	Entry
IDICHQVLEAHPTYP	TTC21B	1286	Q7Z4L5
SVEPSSECVGEPYHV	ANTXRL	256	A6NF34
SECVGEPYHVVIHGN	ANTXRL	261	A6NF34
PAHYPVHECVFKGDV	ANKRD13C	111	Q8N6S4
FDCPHGDKVHPSYTV	ASB14	451	A6NK59
PPGYHLSEHTRICED	FBN3	1591	Q75N90
ECHAVGPEAHTIPGY	BMP2K	911	Q9NSY1
HAHVDSGPVYPETIC	P4HTM	326	Q9NXG6
QAEDVTFLYHPCAHP	TP53I13	61	Q8NBR0
TLPPETKVFCGHEHT	HAGHL	161	Q6PII5
TADAHHYLCTDVAPP	JAK1	416	P23458
HYLCTDVAPPLIVHN	JAK1	421	P23458
TADAHHYLCKEVAPP	JAK2	376	O60674
YTCHVQHEGLPEPLT	HLA-H	281	P01893
SPSRHDEIEYDVPCH	HECA	421	Q9UBI9
IPYGSHIIPFHLCQD	LRR1	336	Q96L50
LELAVCAIHPVPGHY	KCNN1	191	Q92952
PPPVVHYSDHECSIV	ENOX2	241	Q16206
TPLSAAAHTHPVYCV	DYNC1I1	381	O14576
DLVHPLVYCPELHFS	NPEPL1	406	Q8NDH3
PTMPHTIGCEHIFCY	PEX2	251	P28328
HADIPETCVHYVGGP	NOL6	626	Q9H6R4
VHCTHEMCPEEYPHL	NCKAP1L	576	P55160
EPVDCSIPDHHQVYA	PAPPA	1281	Q13219
GTYSVPPHVSEPCHR	NIM1K	286	Q8IY84
SFGLHPSPVHVCTEE	MYOCD	481	Q8IZQ8
YHPHDCGIVTQPLQE	OOSP1	76	A8MZH6
EICAGPHLPHSTVYS	RELN	611	P78509
CHTDITPSVPPASYH	OSCAR	16	Q8IYS5
PTVDVPDHAHYTLGT	OPN4	61	Q9UHM6
VPEHPCVSPVSNHVY	PRPF19	11	Q9UMS4
TGEPHSLICTSYHPD	PAPPA2	1211	Q9BXP8
THHGKYEIPAQSPTC	FZD10	566	Q9ULW2
TPQHGDVYTCHVEHP	HLA-DQB1	196	P01920
DVYTCHVEHPSLQNP	HLA-DQB1	201	P01920
EVYGHRLHNPTECPY	ADAMTS9	1791	Q9P2N4
ILEPPYIEAHHRVCT	GPHB5	71	Q86YW7
LYTPCHGHPVTNLAD	DCDC2B	56	A2VCK2
DHGDGTHTITYIPLC	FLNA	1211	P21333
SCVIPISHFIPSYHH	MARF1	1116	Q9Y4F3
HESSPHRLDTEAPYC	KPRP	516	Q5T749
PVYKVIAPGGHCIHE	SLC44A5	401	Q8NCS7
PPDAESVHSIYHADC	CACNA1H	566	O95180
AHEGVPSGHLYCISP	DLEC1	1376	Q9Y238
HCLIDADIPVSYVTP	SACS	3081	Q9NZJ4
EEVGTPHQDVPCDYH	LRRN4	536	Q8WUT4
PYDHSRVHLTPVEGV	PTPRA	276	P18433
IAYGTDTIHPPDHVI	NXPE1	521	Q8N323
CGYPVTTFEVPVSVH	PCDH11Y	1026	Q9BZA8
YHGTTAPAVPDICAH	PARP10	886	Q53GL7
HHPPVSGFYAECTER	OSBPL11	511	Q9BXB4
SHEVPHYFCDLTPIL	OR1M1	171	Q8NGA1
VAAGVVPSPFEHCHV	SHMT1	236	P34896
IPYLTHPLCHQDVVS	PNKD	201	Q8N490
PEHGRPCYHTLGLEV	PIGQ	601	Q9BRB3
ILPPVHVQCGEHYSE	PTPN14	336	Q15678
ISVLDYPHCVVHELP	STRIP1	631	Q5VSL9
YPHCVVHELPELTAE	STRIP1	636	Q5VSL9
EQHEYTEPTCHLPAV	SIPA1L1	1231	O43166
FGEHPFYHCLVAEVP	SAT1	46	P21673
AFHPICTYIEIGHHP	SEMA3A	136	Q14563
TVIVCPGHYVVHGTF	SHCBP1	381	Q8NEM2
PAEIPVHEVECSYST	ITGAL	626	P20701
HQACPITGYPTEVQH	PEX12	336	O00623
QSHDCVPVLSEHPLY	ACSS3	281	Q9H6R3
EEPTSPIGHCVAIYH	TRIP10	536	Q15642
EVGVVHIFHPVHCDP	CHSY3	826	Q70JA7
DDACTYHPGVPVFHD	CHORDC1	21	Q9UHD1
PSDLPHTFEYVVGHT	ZNF440	551	Q8IYI8
PPAPLCHSDDYVHIS	TSC1	396	Q92574
VEEAFPHIYSHGCVL	SPIRE2	651	Q8WWL2
YTHSAGRPTPEALHC	ZBTB41	36	Q5SVQ8
PRVAPEHEGHYVCEV	FLT4	641	P35916
HCDTAVGTPDYISPE	ROCK2	246	O75116
HCTLVIHPTEHSPTY	PLEKHH1	761	Q9ULM0
FEEHCYVILHVPQSP	VILL	36	O15195
DGTHPEQGLYTCPAH	ZNF547	106	Q8IVP9
DGVYVFHPHSQPVSC	WDR76	351	Q9H967
CHGHYPEILVVDATS	WDR7	131	Q9Y4E6
TEHVRTHTGEIPYEC	ZFP37	421	Q9Y6Q3
HVIEPSYKCHSVEIP	ZPBP2	181	Q6X784
EDGSTAYIHHPVAVP	ZNF76	91	P36508