Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesspositive regulation of mitotic cell cycle phase transition

PLCB1 SMARCD3 HSPA2 TFDP1 DDX3X CDC23

5.39e-06117786GO:1901992
GeneOntologyBiologicalProcesspositive regulation of cell cycle phase transition

PLCB1 SMARCD3 HSPA2 TFDP1 DDX3X CDC23

1.51e-05140786GO:1901989
GeneOntologyBiologicalProcesspositive regulation of mitotic cell cycle

PLCB1 SMARCD3 HSPA2 TFDP1 DDX3X CDC23

2.69e-05155786GO:0045931
GeneOntologyBiologicalProcessribosome biogenesis

IMP4 GNL2 KRI1 DHX29 RPL7A DNTTIP2 DDX3X UTP14C

3.97e-05336788GO:0042254
GeneOntologyCellularComponentcytosolic ribosome

RPL36AL RPL36A ASCC2 DHX29 RPL7A DDX3X

6.48e-06124776GO:0022626
DomainRibosomal_L44e

RPL36AL RPL36A

1.72e-052782IPR000552
DomainRibosomal_L44

RPL36AL RPL36A

1.72e-052782PF00935
DomainRibosomal_L44e

RPL36AL RPL36A

1.72e-052782PD002841
DomainRIBOSOMAL_L44E

RPL36AL RPL36A

1.72e-052782PS01172
Domain-

RPL36AL RPL36A

1.72e-0527823.10.450.80
DomainTransc_factor_DP_C

TFDP1 TFDP2

5.15e-053782IPR014889
DomainDP

TFDP1 TFDP2

5.15e-053782PF08781
DomainDP

TFDP1 TFDP2

5.15e-053782SM01138
DomainTranscrpt_fac_DP

TFDP1 TFDP2

5.15e-053782IPR015648
DomainTPR_11

STIP1 CDC23

3.57e-047782PF13414
DomainRecF/RecN/SMC_N

SMC6 RAD50

4.74e-048782IPR003395
DomainSMC_N

SMC6 RAD50

4.74e-048782PF02463
DomainIQ_motif_EF-hand-BS

IQSEC2 SCN7A ASPM UBE3C

5.48e-0490784IPR000048
DomainRibosomal_zn-bd

RPL36AL RPL36A

6.08e-049782IPR011332
DomainE2F_TDP

TFDP1 TFDP2

9.24e-0411782PF02319
DomainE2F_TDP

TFDP1 TFDP2

9.24e-0411782SM01372
DomainE2F_WHTH_DNA-bd_dom

TFDP1 TFDP2

9.24e-0411782IPR003316
DomainTPR_8

TANC2 STIP1 CDC23

1.41e-0353783PF13181
DomainAnticodon-bd

IMP4 NCOA5

1.52e-0314782IPR004154
DomainTPR

TANC2 STIP1 TTC9C CDC23

2.09e-03129784SM00028
Domain-

KAT6A COPS4 RGS9 TFDP1 TFDP2

2.19e-032187851.10.10.10
DomainTPR_repeat

TANC2 STIP1 TTC9C CDC23

2.33e-03133784IPR019734
DomainP-loop_NTPase

TANC2 NLRP9 ATAD3A SMC6 ASPM GNL2 ZNFX1 DHX29 DDX3X RAD50

2.71e-038487810IPR027417
DomainTPR-like_helical_dom

TANC2 COPS4 STIP1 TTC9C CDC23

2.92e-03233785IPR011990
DomainIQ

IQSEC2 ASPM UBE3C

3.27e-0371783PF00612
DomainWHTH_DNA-bd_dom

KAT6A COPS4 RGS9 TFDP1 TFDP2

3.43e-03242785IPR011991
DomainTPR-contain_dom

TANC2 STIP1 TTC9C CDC23

3.60e-03150784IPR013026
DomainIQ

SCN7A ASPM UBE3C

4.73e-0381783SM00015
DomainTPR_REGION

TANC2 STIP1 TTC9C CDC23

5.04e-03165784PS50293
DomainTPR

TANC2 STIP1 TTC9C CDC23

5.04e-03165784PS50005
DomainIQ

IQSEC2 ASPM UBE3C

6.94e-0393783PS50096
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

SARS2 RPL36A TAPT1 SNX6 MYCBP2 ATAD3A USP11 ASPM GNL2 COPS4 ASCC2 KRI1 STIP1 DHX29 HSPA2 TOR1AIP1 RPL7A TFDP1 DNTTIP2 GSR KIAA0753

8.21e-121487782133957083
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

RPL36A ERP44 ATAD3A SMC6 DOCK7 GNL2 COPS4 KRI1 STIP1 UBE3C DHX29 TOR1AIP1 RPL7A DNTTIP2 DDX3X GSR STX12 RAD50 NCOA5

2.59e-101425781930948266
Pubmed

The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.

SARS2 RPL36A ATAD3A GNL2 COPS4 ASCC2 KRI1 STIP1 TTC9C DHX29 TFDP1

3.96e-08547781137267103
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

RPL36AL RPL36A ATAD3A ZC3H4 IMP4 GNL2 KRI1 MVP TOR1AIP1 RPL7A DNTTIP2 DDX3X NCOA5

4.96e-08847781335850772
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

ERP44 MYCBP2 ATAD3A ZC3H4 DOCK7 GNL2 STIP1 TOR1AIP1 RPL7A DNTTIP2 DDX3X CDC23 RAD50 NCOA5

5.98e-081024781424711643
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

RPL36A SNX6 IMP4 DOCK7 GNL2 KRI1 DHX29 TOR1AIP1 DNTTIP2

6.04e-0833278925693804
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

MYCBP2 IMP4 KAT6A SMC6 ASPM GNL2 KRI1 UBE3C DHX29 RPL7A DNTTIP2 NCOA5

1.25e-07759781235915203
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MYCBP2 ATAD3A USP11 DOCK7 GNL2 KRI1 MVP HSPA2 RPL7A DNTTIP2 RAD50

2.34e-07653781122586326
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

MYCBP2 USP11 IMP4 GNL2 ASCC2 DHX29 DNTTIP2 DDX3X CDC23

6.45e-0744078934244565
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

RPL36AL RPL36A ERP44 MYCBP2 ATAD3A ZC3H4 DOCK7 GNL2 SMARCD3 MVP RPL7A DDX3X NCOA5

8.07e-071082781338697112
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

SARS2 RPL36A ERP44 MYCBP2 ATAD3A USP11 ASPM GNL2 COPS4 SH3BP5L STIP1 RIMS1 DDX3X RAD50

9.17e-071284781417353931
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

CFAP91 SARS2 SNX6 MYCBP2 USP11 ATRNL1 IQSEC2 COPS4 ZNFX1 MVP HSPA2 DDX3X TMED4 SCAI

9.25e-071285781435914814
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

ASPM KRI1 NEB RPL7A DDX3X UTP14C RAD50

1.00e-0623478736243803
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

RPL36A ZC3H4 GNL2 COPS4 STIP1 DHX29 TOR1AIP1 RPL7A DNTTIP2 DDX3X GSR RAD50

1.12e-06934781233916271
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

RPL36AL RPL36A ATAD3A IMP4 GNL2 KRI1 RPL7A DNTTIP2 DDX3X

1.39e-0648378936912080
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

TANC2 MYCBP2 ATAD3A ARFGAP3 IQSEC2 DOCK7 PLCB1 ZNFX1 STIP1 RIMS1 DHX29 HSPA2 RPL7A

1.43e-061139781336417873
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

ATAD3A ZC3H4 USP11 GNL2 ASCC2 SMARCD3 UBE3C RPL7A DDX3X

1.47e-0648678930940648
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

RPL36A SNX6 MYCBP2 ZC3H4 USP11 DOCK7 COPS4 STIP1 HSPA2 RPL7A DDX3X GSR RAD50

1.57e-061149781335446349
Pubmed

Celecoxib inhibits interleukin-12 alphabeta and beta2 folding and secretion by a novel COX2-independent mechanism involving chaperones of the endoplasmic reticulum.

IL12B ERP44

4.97e-06278216467190
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

SARS2 SNX6 MYCBP2 ATAD3A ZC3H4 USP11 ARFGAP3 IMP4 GNL2 STIP1 UBE3C TOR1AIP1 CDC23 NCOA5

5.41e-061496781432877691
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

ERP44 SNX6 MYCBP2 COPS4 TMEM30A CDYL STIP1 UBE3C TOR1AIP1 RPL7A DDX3X TMED4 GSR

5.88e-061297781333545068
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

TANC2 ZC3H4 USP11 KAT6A ASPM GNL2 SMARCD3 TFDP1 DNTTIP2 TFDP2 CDC23 RAD50

6.93e-061116781231753913
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

TANC2 CFAP91 MYCBP2 ARFGAP3 IQSEC2 SMC6 DOCK7 EXOC6B COPS4 TMED4 CDC23 CLASRP RAD50

7.16e-061321781327173435
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

SARS2 RPL36A ERP44 ATAD3A USP11 COPS4 ASCC2 STIP1 HSPA2 RPL7A DDX3X CDC23 RAD50

8.02e-061335781329229926
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

RPL36AL RPL36A TAPT1 KAT6A GNL2 KRI1 NCOA5

9.64e-0633078733301849
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TANC2 MYCBP2 ZC3H4 IQSEC2 DOCK7 PLCB1 ZNFX1 STIP1 RIMS1 DDX3X RAD50

9.92e-06963781128671696
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

RPL36AL RPL36A SNX6 ATAD3A CST2 STIP1 MVP DHX29 TOR1AIP1 RPL7A DDX3X STX12 RAD50

1.03e-051367781332687490
Pubmed

The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival.

RPL36AL RPL36A ATAD3A GNL2 COPS4 KRI1

1.05e-0522078631822558
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

ERP44 SNX6 ATAD3A USP11 KRI1 STIP1 UBE3C DHX29 RPL7A GSR RAD50

1.10e-05974781128675297
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

SARS2 RPL36A ZC3H4 GNL2 ZNFX1 DHX29 RPL7A DNTTIP2 DDX3X NCOA5

1.30e-05807781022681889
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

SARS2 ERP44 MYCBP2 USP11 SURF2 DOCK7 GNL2 COPS4 KRI1 STIP1 RAD50

1.48e-051005781119615732
Pubmed

Dp1 is largely dispensable for embryonic development.

TFDP1 TFDP2

1.49e-05378215282318
Pubmed

The MES-1 murine enhancer element is closely associated with the heterogeneous 5' ends of two divergent transcription units.

SURF2 RPL7A

1.49e-0537823025660
Pubmed

One of the tightly clustered genes of the mouse surfeit locus is a highly expressed member of a multigene family whose other members are predominantly processed pseudogenes.

SURF2 RPL7A

1.49e-0537823221868
Pubmed

Genomic structure and developmental expression of the mouse cell cycle regulatory transcription factor DP1.

TFDP1 TFDP2

1.49e-0537829000141
Pubmed

Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein.

RPL36AL RPL36A

1.49e-0537823542712
Pubmed

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

C14orf93 SARS2 ERP44 ATAD3A TMEM30A TFDP1 TFDP2 UTP14C

1.65e-0549978822810586
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

ERP44 ATAD3A IMP4 STIP1 NEB MVP HSPA2 RPL7A DDX3X GSR

1.91e-05844781025963833
Pubmed

Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.

RPL36AL RPL36A ATAD3A GNL2 RPL7A DDX3X

1.93e-0524578621182205
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

RPL36AL RPL36A SNX6 ATAD3A AP3B2 SMARCD3 DHX29 HSPA2 RPL7A RAD50

1.96e-05847781035235311
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

MYCBP2 ASPM DOCK7 ZNFX1 MVP CDC23

2.02e-0524778632989298
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

RPL36AL RPL36A USP11 KRI1 RPL7A NCOA5

2.21e-0525178628077445
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

ATAD3A IMP4 DOCK7 GNL2 ASCC2 KRI1 MVP RPL7A DNTTIP2 DDX3X RAD50 NCOA5

2.26e-051257781236526897
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

RPL36AL SARS2 RPL36A ERP44 MYCBP2 ATAD3A USP11 UBE3C HSPA2 RPL7A DDX3X CDC23

2.26e-051257781237317656
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

RNF130 SARS2 TAPT1 SMC6 COPS4 STIP1 UBE3C HSPA2 TMED4 SCAI STX12

2.43e-051061781133845483
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

ERP44 MYCBP2 ATAD3A ASPM UBE3C DHX29 CDC23 SCAI

2.64e-0553378825544563
Pubmed

MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice.

DDX3X UTP14C RAD50

2.72e-052678335920200
Pubmed

Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.

SARS2 SNX6 ATAD3A TMEM30A STIP1 TOR1AIP1 TFDP1 DDX3X SCAI

2.85e-0570478932994395
Pubmed

Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family.

TFDP1 TFDP2

2.97e-0547829027491
Pubmed

DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo.

TFDP1 TFDP2

2.97e-0547828755520
Pubmed

E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription.

TFDP1 TFDP2

2.97e-0547829704927
Pubmed

Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system.

KCNE1 NKX2-5

2.97e-05478215085192
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

C14orf93 RPL36A ATAD3A CDYL TOR1AIP1 RPL7A DNTTIP2 DDX3X CDC23 CLASRP RAD50 NCOA5

3.01e-051294781230804502
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

RPL36AL RPL36A ZC3H4 GNL2 KRI1 DHX29 RPL7A DDX3X CLASRP

3.14e-0571378929802200
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

RPL36AL ATAD3A DOCK7 GNL2 KRI1 DNTTIP2 CDC23

3.87e-0541078726949251
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

SARS2 IQSEC2 IMP4 ABTB1 PLCB1 SMARCD3 DHX29 RPL7A TFDP2 DDX3X

4.14e-05925781028986522
Pubmed

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.

RPL36A ERP44 USP11 COPS4 HSPA2 RPL7A DDX3X

4.37e-0541878732552912
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

ERP44 MYCBP2 IMP4 GNL2 ASCC2 NKX2-5 UBE3C TOR1AIP1 RAD50

4.85e-0575478933060197
Pubmed

RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

RPL36AL RPL36A IMP4 GNL2 ZNFX1 RPL7A DDX3X

4.85e-0542578721081503
Pubmed

Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene.

SURF2 RPL7A

4.94e-0557828586415
Pubmed

Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function.

NKX2-5 SMARCD3

4.94e-05578229183906
Pubmed

Ribosomal protein L7a is encoded by a gene (Surf-3) within the tightly clustered mouse surfeit locus.

SURF2 RPL7A

4.94e-0557822648130
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

RPL36AL RPL36A IMP4 DOCK7 GNL2 MVP HSPA2 RPL7A DNTTIP2 DDX3X

5.13e-05949781036574265
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

ATAD3A ZC3H4 SMC6 GNL2 KRI1 NKX2-5 HSPA2 TOR1AIP1 DNTTIP2 DDX3X

5.36e-05954781036373674
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

ZC3H4 ASPM GNL2 KRI1 STIP1 DHX29 RPL7A DDX3X CDC23 UTP14C

6.21e-05971781033306668
Pubmed

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.

RPL36AL RPL36A ATAD3A DHX29 RPL7A DDX3X STX12 RAD50

6.37e-0560478837616343
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

RPL36AL RPL36A ATAD3A GNL2 MVP DHX29 RPL7A DDX3X

7.22e-0561578831048545
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

RPL36A ZC3H4 IMP4 GNL2 KRI1 RPL7A DNTTIP2 DDX3X RAD50 NCOA5

7.23e-05989781036424410
Pubmed

The Surf-6 gene of the mouse surfeit locus encodes a novel nucleolar protein.

SURF2 RPL7A

7.40e-0567828639267
Pubmed

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.

TFDP1 TFDP2

7.40e-05678220176812
Pubmed

The mouse surfeit locus contains a cluster of six genes associated with four CpG-rich islands in 32 kilobases of genomic DNA.

SURF2 RPL7A

7.40e-0567822300057
Pubmed

The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1.

SURF2 RPL7A

7.40e-0567828499913
Pubmed

Human transcription factor protein interaction networks.

RPL36AL RPL36A ATAD3A USP11 GNL2 KRI1 NKX2-5 SMARCD3 STIP1 TFDP1 TFDP2 RAD50

7.81e-051429781235140242
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

TANC2 ATAD3A IQSEC2 AP3B2 DOCK7 ZNFX1 STIP1 RIMS1 DHX29 HSPA2 RPL7A SCAI

7.91e-051431781237142655
Pubmed

Proximity interactions among centrosome components identify regulators of centriole duplication.

MYCBP2 DOCK7 STIP1 KIAA0753

8.10e-0510178424613305
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

RPL36A MYCBP2 ATAD3A SMC6 DOCK7 KRI1 RPL7A CDC23 NCOA5

8.30e-0580978932129710
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

RPL36A ATAD3A DOCK7 GNL2 ASCC2 KRI1 STIP1 UBE3C DHX29 HSPA2 STX12 RAD50

8.39e-051440781230833792
Pubmed

A protein interaction landscape of breast cancer.

COPS4 SMARCD3 UBE3C HSPA2 RPL7A TFDP1 TFDP2 STX12

8.92e-0563478834591612
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

MYCBP2 ATAD3A DOCK7 HSPA2 DDX3X

9.41e-0520278524639526
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ERP44 ATRNL1 IQSEC2 PLCB1

9.42e-051057849628581
Pubmed

LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion.

ERP44 ATAD3A STIP1 MVP RPL7A DDX3X

9.60e-0532778631409639
Pubmed

Mesodermal expression of Moz is necessary for cardiac septum development.

KAT6A NKX2-5

1.04e-04778225912687
Pubmed

Dp1 is required for extra-embryonic development.

TFDP1 TFDP2

1.04e-04778212588846
Pubmed

A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.

KCNE1 NKX2-5

1.04e-04778217604724
Pubmed

The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome.

RPL36AL RPL7A

1.04e-0477821577483
Pubmed

Constitutive knockout of Surf1 is associated with high embryonic lethality, mitochondrial disease and cytochrome c oxidase deficiency in mice.

SURF2 RPL7A

1.04e-04778212566387
Pubmed

In vivo association of E2F and DP family proteins.

TFDP1 TFDP2

1.04e-0477827739537
Pubmed

E2F-6, a member of the E2F family that can behave as a transcriptional repressor.

TFDP1 TFDP2

1.04e-0477829501179
Pubmed

Directed proteomic analysis of the human nucleolus.

IMP4 GNL2 HSPA2 RPL7A RAD50

1.08e-0420878511790298
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

CEP95 AP3B2 DOCK7 RIMS1 RAD50

1.08e-0420878533230847
Pubmed

Quantitative analysis of PPT1 interactome in human neuroblastoma cells.

DOCK7 STIP1 HSPA2 RPL7A DDX3X

1.13e-0421078526217791
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

ATAD3A SMC6 RPL7A DNTTIP2 RAD50 NCOA5

1.19e-0434078629478914
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TANC2 ERP44 ATAD3A ATRNL1 KIAA0753 UTP14C NCOA5

1.22e-0449378715368895
Pubmed

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

SARS2 GNL2 KRI1 DNTTIP2 RAD50 NCOA5

1.37e-0434978625665578
Pubmed

Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter.

DOCK7 RPL7A

1.38e-04878219129230
Pubmed

Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

TFDP1 TFDP2

1.38e-04878216360038
Pubmed

The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.

SARS2 ATAD3A STIP1 MVP HSPA2 RPL7A

1.39e-0435078626549023
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

RPL36AL RPL36A IMP4 GNL2 KRI1 HSPA2 RPL7A DDX3X

1.41e-0467878830209976
Pubmed

Evolutionarily conserved regulators of tau identify targets for new therapies.

RNF130 ERP44 SNX6 TMEM30A STIP1 TOR1AIP1 STX12

1.62e-0451678736610398
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

TANC2 MYCBP2 ZC3H4 TOR1AIP1 RPL7A NCOA5

1.64e-0436178630344098
InteractionRBM4B interactions

RPL36AL SNX6 ZC3H4 IMP4 KAT6A GNL2 ASCC2 KRI1 DNTTIP2

7.71e-07262789int:RBM4B
InteractionDOT1L interactions

RPL36AL RPL36A ATAD3A ZC3H4 IMP4 GNL2 KRI1 UBE3C MVP TOR1AIP1 DNTTIP2 DDX3X SCAI NCOA5

2.30e-068077814int:DOT1L
InteractionBIRC3 interactions

RPL36A ERP44 ATAD3A SMC6 COPS4 KRI1 STIP1 USP35 UBE3C DHX29 TOR1AIP1 RPL7A DNTTIP2 DDX3X GSR STX12 RAD50 NCOA5

2.50e-0613347818int:BIRC3
InteractionIFI16 interactions

SARS2 RPL36A SNX6 IMP4 ASPM DOCK7 GNL2 KRI1 DHX29 TOR1AIP1 RPL7A DNTTIP2 DDX3X

3.28e-067147813int:IFI16
InteractionSNRNP40 interactions

ZC3H4 KAT6A GNL2 COPS4 KRI1 CDYL STIP1 RPL7A TFDP1 DNTTIP2 CLASRP NCOA5

5.79e-066377812int:SNRNP40
InteractionFBXL6 interactions

SARS2 RPL36A ATAD3A GNL2 COPS4 ASCC2 KRI1 STIP1 TTC9C DHX29 TFDP1

1.45e-055837811int:FBXL6
InteractionTNIK interactions

TANC2 SNX6 MYCBP2 ZC3H4 IQSEC2 DOCK7 RIMS1 MVP DDX3X

1.62e-05381789int:TNIK
InteractionHECTD1 interactions

MYCBP2 ATAD3A IMP4 KAT6A SMC6 ASPM GNL2 KRI1 STIP1 UBE3C DHX29 RPL7A DNTTIP2 NCOA5

2.20e-059847814int:HECTD1
InteractionPDGFB interactions

RPL36AL MYCBP2 ZC3H4 GNL2 KRI1

2.33e-0588785int:PDGFB
InteractionPURG interactions

RPL36AL ZC3H4 IMP4 GNL2 ASCC2 KRI1 ZNFX1

2.51e-05223787int:PURG
InteractionPPP1CC interactions

TANC2 CSRNP2 MYCBP2 ATAD3A ZC3H4 USP11 STIP1 HSPA2 TOR1AIP1 RPL7A DDX3X NCOA5

2.52e-057387812int:PPP1CC
InteractionSIRT7 interactions

MYCBP2 ATAD3A USP11 DOCK7 GNL2 COPS4 KRI1 MVP HSPA2 RPL7A DNTTIP2 RAD50

2.72e-057447812int:SIRT7
InteractionSIRT6 interactions

MYCBP2 USP11 IMP4 GNL2 ASCC2 DHX29 HSPA2 DNTTIP2 DDX3X CDC23 RAD50

2.88e-056287811int:SIRT6
InteractionCOP1 interactions

MYCBP2 KAT6A COPS4 MVP HSPA2 RPL7A CLASRP RAD50

3.77e-05326788int:COP1
InteractionFMR1 interactions

MYCBP2 USP11 IQSEC2 KAT6A DOCK7 ZNFX1 STIP1 MVP DDX3X RAD50

4.05e-055367810int:FMR1
InteractionTFDP2 interactions

KAT6A STIP1 TFDP1 TFDP2

5.26e-0553784int:TFDP2
InteractionMAGEB2 interactions

RPL36AL RPL36A ZC3H4 IMP4 GNL2 KRI1 RPL7A DNTTIP2

6.10e-05349788int:MAGEB2
InteractionFBXO42 interactions

ASPM COPS4 SH3BP5L TTC9C RPL7A GSR CDC23

6.48e-05259787int:FBXO42
InteractionCSRNP1 interactions

MYCBP2 ASPM SCAI

7.05e-0521783int:CSRNP1
InteractionPYHIN1 interactions

RPL36AL SARS2 RPL36A USP11 KRI1 RPL7A RAD50 NCOA5

7.28e-05358788int:PYHIN1
InteractionMAPK6 interactions

MYCBP2 ATAD3A USP11 ARFGAP3 KAT6A ASPM STIP1 TOR1AIP1 RAD50

8.84e-05474789int:MAPK6
InteractionRPL13A interactions

RPL36AL RPL36A ZC3H4 IMP4 KAT6A GNL2 KRI1 DHX29 RPL7A DNTTIP2

9.13e-055917810int:RPL13A
InteractionRPS3 interactions

RPL36AL IMP4 KAT6A GNL2 ASCC2 KRI1 STIP1 DHX29 RPL7A DNTTIP2 DDX3X

9.99e-057217811int:RPS3
InteractionUSP36 interactions

RPL36AL RPL36A ATAD3A IMP4 GNL2 KRI1 HSPA2 RPL7A DNTTIP2 DDX3X

1.02e-045997810int:USP36
InteractionDNAJB6 interactions

SNX6 ASPM GNL2 KRI1 STIP1 HSPA2 TOR1AIP1 DNTTIP2

1.08e-04379788int:DNAJB6
InteractionRPS13 interactions

RPL36AL SURF2 KAT6A ASCC2 KRI1 STIP1 NEB RPL7A DDX3X

1.12e-04489789int:RPS13
InteractionSTIP1 interactions

RNF130 SNX6 ATAD3A COPS4 STIP1 UBE3C NEB HSPA2 RPL7A TFDP2 DDX3X KIAA0753 RAD50

1.19e-0410067813int:STIP1
InteractionMEN1 interactions

RPL36AL RPL36A ATAD3A ZC3H4 IMP4 SMC6 GNL2 KRI1 MVP TOR1AIP1 RPL7A DNTTIP2 CDC23

1.49e-0410297813int:MEN1
InteractionH3C1 interactions

RPL36A ZC3H4 KAT6A SMC6 GNL2 KRI1 CDYL NEB RPL7A DNTTIP2 CDC23 RAD50

1.69e-049017812int:H3C1
InteractionNPM1 interactions

RPL36AL IMP4 KAT6A ASPM GNL2 ASCC2 KRI1 STIP1 NEB DHX29 RPL7A DNTTIP2 DDX3X RAD50

1.87e-0412017814int:NPM1
InteractionMKI67 interactions

RPL36AL ATAD3A USP11 SMC6 ASPM DOCK7 GNL2 KRI1 DNTTIP2 CDC23

1.93e-046487810int:MKI67
InteractionDCAF1 interactions

RPL36AL KAT6A DOCK7 COPS4 RPL7A RAD50

2.33e-04224786int:DCAF1
InteractionZBTB47 interactions

RPL36AL IMP4 GNL2 KRI1 RPL7A

2.41e-04144785int:ZBTB47
InteractionZNF2 interactions

IMP4 GNL2 RPL7A DNTTIP2

2.63e-0480784int:ZNF2
InteractionH2AC17 interactions

RPL36AL IMP4 GNL2 ASCC2 KRI1 CDYL

2.81e-04232786int:H2AC17
InteractionRPL14 interactions

RPL36AL RPL36A SNX6 IMP4 KAT6A GNL2 STIP1 DHX29 RPL7A

2.84e-04554789int:RPL14
InteractionDNAJC16 interactions

TAPT1 TMEM30A STIP1 HSPA2 TOR1AIP1 RPL7A

2.87e-04233786int:DNAJC16
InteractionDNAJB7 interactions

MYCBP2 ASPM RPL7A

3.06e-0434783int:DNAJB7
InteractionMCIDAS interactions

TFDP1 TFDP2

3.07e-047782int:MCIDAS
InteractionFAF1 interactions

MYCBP2 USP11 ASCC2 STIP1 UBE3C HSPA2 RPL7A

3.11e-04334787int:FAF1
InteractionDDX60 interactions

RPL36A ASCC2 STIP1 UBE3C

3.31e-0485784int:DDX60
InteractionAPEX1 interactions

SARS2 IQSEC2 IMP4 KAT6A GNL2 ABTB1 PLCB1 KRI1 SMARCD3 DHX29 RPL7A DNTTIP2 TFDP2 DDX3X

3.35e-0412717814int:APEX1
InteractionRPS10 interactions

RPL36AL IMP4 GNL2 ASCC2 KRI1 STIP1 DHX29 RPL7A DDX3X

3.36e-04567789int:RPS10
InteractionZBTB2 interactions

RPL36AL RPL36A TAPT1 KAT6A GNL2 KRI1 TTC9C NCOA5

3.47e-04450788int:ZBTB2
InteractionDGCR8 interactions

RPL36AL IMP4 SMC6 GNL2 RPL7A DNTTIP2

3.52e-04242786int:DGCR8
InteractionRPL17 interactions

RPL36AL RPL36A IMP4 KAT6A GNL2 KRI1 STIP1 DHX29 RPL7A

3.54e-04571789int:RPL17
InteractionNAA40 interactions

RPL36A ZC3H4 GNL2 COPS4 STIP1 DHX29 TOR1AIP1 RPL7A DNTTIP2 DDX3X GSR RAD50

3.59e-049787812int:NAA40
InteractionNAP1L1 interactions

RPL36AL RPL36A KAT6A ASPM STIP1 RPL7A CDC23

3.78e-04345787int:NAP1L1
InteractionMAFB interactions

RPL36AL RPL36A ATAD3A GNL2 COPS4 KRI1

3.84e-04246786int:MAFB
InteractionTULP3 interactions

SARS2 USP11 COPS4 ASCC2 NEB DNTTIP2 CDC23

3.85e-04346787int:TULP3
InteractionMIER2 interactions

USP11 CDYL TFDP1

3.94e-0437783int:MIER2
InteractionRIN3 interactions

RPL36A ERP44 USP11 ASPM COPS4 HSPA2 RPL7A DDX3X

4.19e-04463788int:RIN3
InteractionSMC5 interactions

ATAD3A ZC3H4 SMC6 GNL2 COPS4 KRI1 NKX2-5 HSPA2 TOR1AIP1 DNTTIP2 DDX3X RAD50

4.39e-0410007812int:SMC5
InteractionCUL4B interactions

MYCBP2 USP11 GNL2 COPS4 STIP1 UBE3C TOR1AIP1 RPL7A DDX3X RAD50

4.87e-047287810int:CUL4B
InteractionRPL30 interactions

RPL36AL RPL36A IMP4 KAT6A GNL2 DHX29 RPL7A DDX3X

4.90e-04474788int:RPL30
InteractionIL12B interactions

IL12B ERP44

5.23e-049782int:IL12B
InteractionTATDN3 interactions

HSPA2 RAD50

5.23e-049782int:TATDN3
InteractionRPS6 interactions

RPL36AL RPL36A IMP4 KAT6A GNL2 ASCC2 KRI1 DHX29 RPL7A DNTTIP2 DDX3X

5.23e-048747811int:RPS6
InteractionREXO4 interactions

RPL36AL IMP4 KAT6A GNL2 KRI1 RPL7A

5.25e-04261786int:REXO4
InteractionPEX3 interactions

SNX6 ATAD3A UBE3C RPL7A CDC23

5.31e-04171785int:PEX3
GeneFamilyTranscription factor Dp family

TFDP1 TFDP2

1.98e-053472987
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

TANC2 STIP1 TTC9C CDC23

2.24e-04115474769
GeneFamilyL ribosomal proteins

RPL36AL RPL36A RPL7A

3.14e-0451473729
CoexpressionHE_LIM_SUN_FETAL_LUNG_C2_PRE_PDC_DC5_CELL

SARS2 ATAD3A USP11 CEP95 SMC6 ASPM KRI1 CDYL TFDP1 CDC23

7.33e-065787710M45744
CoexpressionRODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP

SMC6 ASPM GNL2 PLCB1 TMEM30A CDYL STIP1 UBE3C DNTTIP2 DDX3X RAD50

8.11e-067217711M10237
CoexpressionGSE31082_DN_VS_CD4_SP_THYMOCYTE_UP

RPL36A DHX29 DNTTIP2 TFDP2 STX12 RAD50

2.77e-05200776M5057
CoexpressionGSE26351_UNSTIM_VS_WNT_PATHWAY_STIM_HEMATOPOIETIC_PROGENITORS_UP

CSRNP2 IQSEC2 DDX3X KIAA0753 RAD50 NCOA5

2.77e-05200776M8482
CoexpressionGSE14413_UNSTIM_VS_IFNB_STIM_NIH3T3_CELLS_DN

ERP44 SNX6 EXOC6B DHX29 TFDP2

5.30e-05137775M471
Drugbenserazide hydrochloride; Up 200; 10uM; MCF7; HG-U133A

TANC2 ARFGAP3 PLCB1 KRI1 CDYL MVP STX12

5.48e-06199787641_UP
Drugtolbutamide; Up 200; 100uM; MCF7; HG-U133A

SNX6 MYCBP2 SURF2 ASCC2 KRI1 CDYL STX12

5.48e-06199787142_UP
DiseaseNeurodevelopmental Disorders

TANC2 ZC3H4 IQSEC2 RIMS1 DDX3X

3.54e-0693735C1535926
DiseaseMalignant neoplasm of breast

NLRP9 ABHD12B ARFGAP3 SMC6 PLCB1 TOR1AIP1 DDX3X CLASRP STX12

1.30e-031074739C0006142
DiseaseATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)

KCNE1 NKX2-5

1.35e-0322732C1843687
Diseasesleep duration, low density lipoprotein cholesterol measurement

DOCK7 TMED4 CLASRP

1.51e-0391733EFO_0004611, EFO_0005271
Diseasebreast cancer (implicated_via_orthology)

BECN2 RAD50

1.75e-0325732DOID:1612 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
QAYRHAIEVNKRDYR

CDC23

386

Q9UJX2
SSTYKDRNEEYRRQF

GRAMD1C

61

Q8IYS0
TNAKYNSRAAQLYRE

ARFGAP3

101

Q9NP61
YYEARRLAKEAQQET

SH3BP5L

116

Q7L8J4
LRRKNVRFDQVTVYY

CSRNP2

61

Q9H175
ARAQYQDKLARQRYE

ATAD3A

176

Q9NVI7
DKRAVAAQRQRYEQY

ASCC2

576

Q9H1I8
KRDAYVSRLNAIYQN

GSR

146

P00390
YEIARNAYRNKERVK

ABHD12B

316

Q7Z5M8
LLSNDRRFYSERYKV

DHX29

886

Q7Z478
QQHYRTYRAAKLQRE

ASPM

2511

Q8IZT6
TYRAAKLQRENYIRQ

ASPM

2516

Q8IZT6
ERRNIIKDYSDYASQ

CFAP91

356

Q7Z4T9
LAKYDQNYDIRDRAR

AP3B2

566

Q13367
ENVSASDKRRNYNYR

RAD50

1171

Q92878
YRAGKERNKADRYAL

RGS9

166

O75916
YFIQKIRYTNARDRN

RNF130

216

Q86XS8
EYLYRKAREEAQRSA

IMP4

11

Q96G21
QIYEEARKFSYRSRV

DDX3X

281

O00571
VRYYETHNVKNRNRN

GNL2

696

Q13823
NNDIDYYAKRNALRA

GALNT9

386

Q9HCQ5
GAYQNREAVYRDKER

IQSEC2

121

Q5JU85
RDRVAAKNALESYTY

HSPA2

536

P54652
KEDYYRRFSVQRCAR

LHX9

121

Q9NQ69
ARNYERYKNECREKE

NCOA5

291

Q9HCD5
DYRRKFIEAAQRYNE

COPS4

196

Q9BT78
RVNAAFAARYNRYRE

KRI1

11

Q8N9T8
NINAIRDYSFKRLYR

LINGO1

226

Q96FE5
GARETFENYYRKQRR

EXOC6B

306

Q9Y2D4
DSLYAQGRRRYDRKQ

RPL36AL

31

Q969Q0
RKNASISVRAQDRYY

IL12B

301

P29460
YELERRFKQQRYLSA

NKX2-5

151

P52952
AAVQVYDYREKRARV

MVP

466

Q14764
RKEEDYQTRYRSDPN

RIMS1

346

Q86UR5
VDYSEQYRIRKRGNR

KAT6A

431

Q92794
QQERQHYRDYSALKR

BECN2

206

A8MW95
KDRITYFDKNYNLRR

DOCK7

1926

Q96N67
ESAYRYRDIVVRKQD

CDYL

336

Q9Y232
AYFLTKRREYRNSLN

C14orf93

366

Q9H972
RVNSSRENYDNAKLY

ATRNL1

761

Q5VV63
QQIVRARKYYDDYRV

CEP95

661

Q96GE4
NFYQNHRRYVKSRDD

TMEM30A

126

Q9NV96
REYRGQRSVKALADY

ERP44

121

Q9BS26
DKAYVQARVLESYRS

KCNE1

91

P15382
NKATEDEYYRRLLRV

CST2

56

P09228
TEKRNRNLLYEYARE

SARS2

36

Q9NP81
ENREDYRQIAKAYAR

STIP1

291

P31948
DSLYAQGKRRYDRKQ

RPL36A

31

P83881
AKLVEAIRTNYNDRY

RPL7A

216

P62424
SRRNSFAYDVKREVY

SLC26A8

16

Q96RN1
RYFYCKIQQRRQELE

SMARCD3

461

Q6STE5
EAYYARARAKRSSRQ

TANC2

1326

Q9HCD6
RYRRIYTAALNDRDQ

MYCBP2

76

O75592
TQGRRYQRALCKYEE

SURF2

101

Q15527
YDVYRRKASERQYQR

SMIM4

51

Q8WVI0
SVRQRYNKIAYADPR

KIAA0753

791

Q2KHM9
ADSAYDQKNIRRRVY

TFDP2

171

Q14188
RDYKQVTASCRRRDY

ABTB1

86

Q969K4
SDERKCNYERYRGLV

CLASRP

106

Q8N2M8
EYKELNDAYTAAARR

NLRP9

131

Q7RTR0
DSEFRRYNRRKYSEI

DNTTIP2

721

Q5QJE6
NESAYDQKNIRRRVY

TFDP1

156

Q14186
LQRARALQSYYEAKA

UTP14C

226

Q5TAP6
KEEVRESAYYLRSRQ

TOR1AIP1

96

Q5JTV8
TRRNSRLAFYYDLDK

RIPOR3

106

Q96MK2
ERATEQLQRAAYYQK

STX12

231

Q86Y82
YLQEQEKEARSRAAY

USP35

961

Q9P2H5
AIRQRSYYSQVNKED

SCAI

156

Q8N9R8
KKRAYNEAEVLYNRS

SMC6

356

Q96SB8
NQRYREGKYRDAVSR

TTC9C

16

Q8N5M4
KYNEIQNDYLRRRAA

PLCB1

951

Q9NQ66
YRRSRSLVDYENANK

SNX6

311

Q9UNH7
YSKELNQYRRSKDSR

ZC3H4

306

Q9UPT8
YQADTRRKILSYERQ

ZNFX1

941

Q9P2E3
QKEQDYQRYREERFR

TMED4

171

Q7Z7H5
YKNYRLRRNDKNTSD

SCN7A

1636

Q01118
HNEAKYTERRERVYT

TAPT1

86

Q6NXT6
AAYVLFYQRQDVARR

USP11

921

P51784
DRKQQYSIQRSAFDR

UBE3C

61

Q15386
QARKAYDLQSDNVYR

NEB

4341

P20929