Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	tau-protein kinase activity	BRSK2 DYRK1A BRSK1	5.11e-06	22	31	3	GO:0050321
GeneOntologyMolecularFunction	U2 snRNA binding	PRPF8 SNRPA1	3.49e-05	6	31	2	GO:0030620
GeneOntologyMolecularFunction	tau protein binding	BRSK2 DYRK1A BRSK1	4.92e-05	46	31	3	GO:0048156
GeneOntologyMolecularFunction	endonuclease activity	AGO1 AGO4 PXDNL	1.21e-03	136	31	3	GO:0004519
GeneOntologyMolecularFunction	miRNA binding	AGO1 AGO4	2.52e-03	48	31	2	GO:0035198
GeneOntologyMolecularFunction	pyridoxal phosphate binding	SPTLC3 KYAT3	3.41e-03	56	31	2	GO:0030170
GeneOntologyMolecularFunction	vitamin B6 binding	SPTLC3 KYAT3	3.53e-03	57	31	2	GO:0070279
GeneOntologyMolecularFunction	snRNA binding	PRPF8 SNRPA1	3.53e-03	57	31	2	GO:0017069
GeneOntologyMolecularFunction	regulatory RNA binding	AGO1 AGO4	4.16e-03	62	31	2	GO:0061980
GeneOntologyMolecularFunction	nuclease activity	AGO1 AGO4 PXDNL	5.41e-03	231	31	3	GO:0004518
GeneOntologyMolecularFunction	double-stranded RNA binding	AGO1 AGO4	6.51e-03	78	31	2	GO:0003725
GeneOntologyMolecularFunction	RNA endonuclease activity	AGO1 AGO4	6.67e-03	79	31	2	GO:0004521
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	AGO1 AGO4 PDE6B PXDNL LRRD1	7.55e-03	807	31	5	GO:0016788
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization involved in establishment of planar polarity	BRSK2 BRSK1	6.55e-06	3	31	2	GO:0090176
GeneOntologyBiologicalProcess	siRNA-mediated gene silencing by mRNA destabilization	AGO1 AGO4	1.31e-05	4	31	2	GO:0090625
GeneOntologyBiologicalProcess	siRNA-mediated post-transcriptional gene silencing	AGO1 AGO4	1.31e-05	4	31	2	GO:0140766
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	BRSK2 ASPM DYRK1A FSIP2 DYNC1LI1 BRSK1 IFT172	7.75e-05	720	31	7	GO:0000226
GeneOntologyBiologicalProcess	RNA secondary structure unwinding	AGO1 AGO4	7.82e-05	9	31	2	GO:0010501
GeneOntologyBiologicalProcess	RISC complex assembly	AGO1 AGO4	9.76e-05	10	31	2	GO:0070922
GeneOntologyBiologicalProcess	regulation of synaptic vesicle clustering	BRSK2 BRSK1	1.43e-04	12	31	2	GO:2000807
GeneOntologyBiologicalProcess	pre-miRNA processing	AGO1 AGO4	2.93e-04	17	31	2	GO:0031054
GeneOntologyBiologicalProcess	protein-RNA complex assembly	AGO1 AGO4 PRPF8 SNRPA1	4.68e-04	244	31	4	GO:0022618
GeneOntologyBiologicalProcess	synaptic vesicle clustering	BRSK2 BRSK1	4.96e-04	22	31	2	GO:0097091
GeneOntologyBiologicalProcess	protein-RNA complex organization	AGO1 AGO4 PRPF8 SNRPA1	5.44e-04	254	31	4	GO:0071826
GeneOntologyCellularComponent	RISC-loading complex	AGO1 AGO4	9.51e-05	10	31	2	GO:0070578
GeneOntologyCellularComponent	microtubule organizing center	BRSK2 ASPM DYNC1LI1 ZFYVE26 BRSK1 CABCOCO1 IFT172	3.23e-04	919	31	7	GO:0005815
GeneOntologyCellularComponent	centrosome	BRSK2 ASPM DYNC1LI1 ZFYVE26 BRSK1 CABCOCO1	8.20e-04	770	31	6	GO:0005813
GeneOntologyCellularComponent	U2-type catalytic step 2 spliceosome	PRPF8 SNRPA1	9.64e-04	31	31	2	GO:0071007
GeneOntologyCellularComponent	endoribonuclease complex	AGO1 AGO4	1.37e-03	37	31	2	GO:1902555
GeneOntologyCellularComponent	endonuclease complex	AGO1 AGO4	1.85e-03	43	31	2	GO:1905348
GeneOntologyCellularComponent	sperm principal piece	FSIP2 IFT172	1.94e-03	44	31	2	GO:0097228
GeneOntologyCellularComponent	U2-type precatalytic spliceosome	PRPF8 SNRPA1	2.59e-03	51	31	2	GO:0071005
GeneOntologyCellularComponent	precatalytic spliceosome	PRPF8 SNRPA1	2.90e-03	54	31	2	GO:0071011
GeneOntologyCellularComponent	sperm flagellum	FSIP2 CABCOCO1 IFT172	3.85e-03	214	31	3	GO:0036126
GeneOntologyCellularComponent	sperm midpiece	FSIP2 IFT172	4.05e-03	64	31	2	GO:0097225
Domain	Argonaute_N	AGO1 AGO4	1.49e-05	4	30	2	IPR032474
Domain	Argonaute_Mid_dom	AGO1 AGO4	1.49e-05	4	30	2	IPR032473
Domain	ArgoL2	AGO1 AGO4	1.49e-05	4	30	2	IPR032472
Domain	ArgoN	AGO1 AGO4	1.49e-05	4	30	2	PF16486
Domain	ArgoMid	AGO1 AGO4	1.49e-05	4	30	2	PF16487
Domain	ArgoL2	AGO1 AGO4	1.49e-05	4	30	2	PF16488
Domain	DUF1785	AGO1 AGO4	2.49e-05	5	30	2	SM01163
Domain	ArgoL1	AGO1 AGO4	3.73e-05	6	30	2	PF08699
Domain	ArgoL1	AGO1 AGO4	3.73e-05	6	30	2	IPR014811
Domain	PIWI	AGO1 AGO4	6.94e-05	8	30	2	PS50822
Domain	Piwi	AGO1 AGO4	6.94e-05	8	30	2	IPR003165
Domain	Piwi	AGO1 AGO4	6.94e-05	8	30	2	PF02171
Domain	Piwi	AGO1 AGO4	6.94e-05	8	30	2	SM00950
Domain	PAZ	AGO1 AGO4	8.92e-05	9	30	2	PS50821
Domain	PAZ_dom	AGO1 AGO4	8.92e-05	9	30	2	IPR003100
Domain	PAZ	AGO1 AGO4	8.92e-05	9	30	2	PF02170
Domain	PAZ	AGO1 AGO4	8.92e-05	9	30	2	SM00949
Domain	RNaseH-like_dom	AGO1 AGO4 PRPF8	1.82e-04	69	30	3	IPR012337
Domain	Aminotransferase_I/II	SPTLC3 KYAT3	3.34e-04	17	30	2	IPR004839
Domain	Aminotran_1_2	SPTLC3 KYAT3	3.34e-04	17	30	2	PF00155
Domain	LRR_1	LRRC34 SNRPA1 PXDNL LRRD1	3.97e-04	219	30	4	PF00560
Domain	Leu-rich_rpt	LRRC34 SNRPA1 PXDNL LRRD1	8.83e-04	271	30	4	IPR001611
Domain	Ets	ETV3 ERF	9.19e-04	28	30	2	PF00178
Domain	ETS_DOMAIN_1	ETV3 ERF	9.19e-04	28	30	2	PS00345
Domain	ETS_DOMAIN_2	ETV3 ERF	9.19e-04	28	30	2	PS00346
Domain	ETS	ETV3 ERF	9.19e-04	28	30	2	SM00413
Domain	Ets_dom	ETV3 ERF	9.19e-04	28	30	2	IPR000418
Domain	ETS_DOMAIN_3	ETV3 ERF	9.19e-04	28	30	2	PS50061
Domain	-	SPTLC3 KYAT3	1.44e-03	35	30	2	3.90.1150.10
Domain	PyrdxlP-dep_Trfase_major_sub2	SPTLC3 KYAT3	1.52e-03	36	30	2	IPR015422
Domain	-	LRRC34 SNRPA1 PXDNL LRRD1	1.65e-03	321	30	4	3.80.10.10
Domain	-	SPTLC3 KYAT3	1.78e-03	39	30	2	3.40.640.10
Domain	L_dom-like	LRRC34 SNRPA1 PXDNL LRRD1	1.78e-03	328	30	4	IPR032675
Domain	PyrdxlP-dep_Trfase	SPTLC3 KYAT3	1.97e-03	41	30	2	IPR015424
Domain	PyrdxlP-dep_Trfase_major_sub1	SPTLC3 KYAT3	1.97e-03	41	30	2	IPR015421
Domain	-	AGO1 AGO4	2.58e-03	47	30	2	3.30.420.10
Domain	LRR	SNRPA1 PXDNL LRRD1	4.02e-03	201	30	3	PS51450
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	BRSK2 BRSK1	5.47e-03	69	30	2	IPR020636
Pathway	REACTOME_ONCOGENE_INDUCED_SENESCENCE	AGO1 AGO4 ERF	1.81e-05	35	21	3	M27190
Pathway	BIOCARTA_DICER_PATHWAY	AGO1 AGO4	2.11e-05	5	21	2	M22079
Pathway	REACTOME_MICRORNA_MIRNA_BIOGENESIS	AGO1 AGO4	3.16e-05	6	21	2	MM14818
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	AGO1 AGO4	3.16e-05	6	21	2	MM15083
Pathway	REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS	AGO1 AGO4	4.42e-05	7	21	2	M46421
Pathway	REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS	AGO1 AGO4	5.89e-05	8	21	2	MM15082
Pathway	REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS	AGO1 AGO4	7.56e-05	9	21	2	M27340
Pathway	REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION	AGO1 AGO4	7.56e-05	9	21	2	M27810
Pathway	REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION	AGO1 AGO4	7.56e-05	9	21	2	M46436
Pathway	REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS	AGO1 AGO4	9.44e-05	10	21	2	M48013
Pathway	REACTOME_CA2_PATHWAY	AGO1 AGO4 PDE6B	1.02e-04	62	21	3	M27321
Pathway	REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION	AGO1 AGO4	1.63e-04	13	21	2	M46434
Pathway	REACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY	AGO1 AGO4	2.84e-04	17	21	2	M27788
Pathway	REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS	AGO1 AGO4	3.56e-04	19	21	2	M48238
Pathway	REACTOME_MICRORNA_MIRNA_BIOGENESIS	AGO1 AGO4	6.21e-04	25	21	2	M712
Pathway	REACTOME_TGFBR3_EXPRESSION	AGO1 AGO4	7.81e-04	28	21	2	M48253
Pathway	REACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION	AGO1 AGO4	1.02e-03	32	21	2	M48012
Pathway	REACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY	AGO1 AGO4	1.02e-03	32	21	2	M27900
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4	AGO1 AGO4	1.15e-03	34	21	2	M46422
Pathway	REACTOME_NUCLEAR_EVENTS_STIMULATED_BY_ALK_SIGNALING_IN_CANCER	AGO1 AGO4	1.22e-03	35	21	2	M42525
Pathway	REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING	AGO1 AGO4 PDE6B	1.26e-03	146	21	3	M27288
Pathway	REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX	AGO1 AGO4	1.36e-03	37	21	2	M29790
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX	AGO1 AGO4	1.67e-03	41	21	2	M29748
Pathway	PID_LKB1_PATHWAY	BRSK2 BRSK1	2.19e-03	47	21	2	M87
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	AGO1 AGO4	2.19e-03	47	21	2	M29777
Pathway	REACTOME_GENE_SILENCING_BY_RNA	AGO1 AGO4	2.38e-03	49	21	2	MM14837
Pathway	REACTOME_SIGNALING_BY_TGFBR3	AGO1 AGO4	2.38e-03	49	21	2	M48250
Pathway	REACTOME_CELLULAR_SENESCENCE	AGO1 AGO4 ERF	2.97e-03	197	21	3	M27188
Pathway	REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS	AGO1 AGO4	3.32e-03	58	21	2	M11980
Pathway	WP_CILIARY_LANDSCAPE	DYNC1LI1 ERF IFT172	3.80e-03	215	21	3	M39734
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2	AGO1 AGO4	3.91e-03	63	21	2	M27862
Pathway	WP_PPAR_SIGNALING	FADS2 MMP1	4.41e-03	67	21	2	M39553
Pathway	KEGG_PPAR_SIGNALING_PATHWAY	FADS2 MMP1	4.67e-03	69	21	2	M13088
Pathway	WP_PPAR_SIGNALING_PATHWAY	FADS2 MMP1	5.21e-03	73	21	2	MM15995
Pubmed	SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.	BRSK2 BRSK1	7.69e-07	2	31	2	16630837
Pubmed	The Importance of AGO 1 and 4 in Post-Transcriptional Gene Regulatory Function of tRF5-GluCTC, an Respiratory Syncytial Virus-Induced tRNA-Derived RNA Fragment.	AGO1 AGO4	7.69e-07	2	31	2	33233493
Pubmed	Effects of Echinococcus multilocularis miR-71 mimics on murine macrophage RAW264.7 cells.	AGO1 AGO4	7.69e-07	2	31	2	26995025
Pubmed	Ets domain transcription factor PE1 suppresses human interstitial collagenase promoter activity by antagonizing protein-DNA interactions at a critical AP1 element.	ETV3 ERF	7.69e-07	2	31	2	10913304
Pubmed	Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.	BRSK2 BRSK1	7.69e-07	2	31	2	18339622
Pubmed	Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.	BRSK2 BRSK1	7.69e-07	2	31	2	30307479
Pubmed	Microtubule stabilization specifies initial neuronal polarization.	BRSK2 BRSK1	2.31e-06	3	31	2	18268107
Pubmed	Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.	BRSK2 BRSK1	2.31e-06	3	31	2	22669945
Pubmed	Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.	BRSK2 BRSK1	2.31e-06	3	31	2	20026642
Pubmed	Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins.	AGO1 AGO4	2.31e-06	3	31	2	19946268
Pubmed	Molecular dissection of human Argonaute proteins by DNA shuffling.	AGO1 AGO4	4.61e-06	4	31	2	23748378
Pubmed	Tuberous sclerosis complex proteins control axon formation.	BRSK2 BRSK1	4.61e-06	4	31	2	18794346
Pubmed	Slicing-independent RISC activation requires the argonaute PAZ domain.	AGO1 AGO4	4.61e-06	4	31	2	22795694
Pubmed	Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.	AGO1 AGO4	4.61e-06	4	31	2	15260970
Pubmed	ATP-dependent human RISC assembly pathways.	AGO1 AGO4	4.61e-06	4	31	2	19966796
Pubmed	Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.	AGO1 AGO4	4.61e-06	4	31	2	18771919
Pubmed	A Requirement for Argonaute 4 in Mammalian Antiviral Defense.	AGO1 AGO4	4.61e-06	4	31	2	32049003
Pubmed	Roles of tau protein in health and disease.	BRSK2 DYRK1A BRSK1	6.19e-06	40	31	3	28386764
Pubmed	Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.	AGO1 AGO4	7.68e-06	5	31	2	12526743
Pubmed	Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.	BRSK2 BRSK1	7.68e-06	5	31	2	15150265
Pubmed	Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.	AGO1 AGO4	7.68e-06	5	31	2	19393748
Pubmed	The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.	AGO1 AGO4	7.68e-06	5	31	2	19324964
Pubmed	C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.	BRSK2 BRSK1	7.68e-06	5	31	2	18854318
Pubmed	Differential expression of components of the microRNA machinery during mouse organogenesis.	AGO1 AGO4	7.68e-06	5	31	2	16036130
Pubmed	The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.	AGO1 AGO4	7.68e-06	5	31	2	12414724
Pubmed	Mammalian SAD kinases are required for neuronal polarization.	BRSK2 BRSK1	1.15e-05	6	31	2	15705853
Pubmed	SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems.	BRSK2 BRSK1	1.15e-05	6	31	2	24395778
Pubmed	Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS.	ETV3 ERF	1.15e-05	6	31	2	17525531
Pubmed	Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.	BRSK2 BRSK1	1.15e-05	6	31	2	21985311
Pubmed	LKB1 and AMPK regulate synaptic remodeling in old age.	BRSK2 BRSK1	1.15e-05	6	31	2	25086610
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	BRSK2 DYRK1A TGM3 MMP1 AGO1 AGO4 BRSK1	1.25e-05	910	31	7	36736316
Pubmed	Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development.	AGO1 AGO4	1.61e-05	7	31	2	34907157
Pubmed	Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.	AGO1 AGO4	1.61e-05	7	31	2	19536157
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	AGO1 AGO4	1.61e-05	7	31	2	19383768
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	AGO1 AGO4	1.61e-05	7	31	2	19470757
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	ASPM KYAT3 AGO1 AGO4 SNRPA1	1.66e-05	364	31	5	24778252
Pubmed	Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis.	AGO1 AGO4	2.15e-05	8	31	2	19345100
Pubmed	Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis.	AGO1 AGO4	2.15e-05	8	31	2	29021386
Pubmed	FAM188B enhances cell survival via interaction with USP7.	PRPF8 SNRPA1 IFT172	2.70e-05	65	31	3	29795372
Pubmed	Identification of eight members of the Argonaute family in the human genome.	AGO1 AGO4	2.76e-05	9	31	2	12906857
Pubmed	A genome-wide perspective of genetic variation in human metabolism.	SPTLC3 ETFDH	2.76e-05	9	31	2	20037589
Pubmed	Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.	BRSK2 BRSK1	5.05e-05	12	31	2	23275438
Pubmed	Nonsyndromic Retinitis Pigmentosa Overview	PRPF8 PDE6B IFT172	5.22e-05	81	31	3	20301590
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	ASPM TGM3 PRPF8	5.82e-05	84	31	3	29563501
Pubmed	The loss of the kinases SadA and SadB results in early neuronal apoptosis and a reduced number of progenitors.	BRSK2 BRSK1	5.96e-05	13	31	2	29698519
Pubmed	LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.	BRSK2 BRSK1	8.02e-05	15	31	2	14976552
Pubmed	Tissue expression patterns identify mouse cilia genes.	LRRC34 CABCOCO1 IFT172	8.66e-05	96	31	3	17971504
Pubmed	Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs.	AGO1 AGO4	9.16e-05	16	31	2	20102707
Pubmed	Identification and characterization of VPO1, a new animal heme-containing peroxidase.	PXDNL IFT172	9.16e-05	16	31	2	18929642
Pubmed	Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.	AGO1 ERFL AGO4	1.01e-04	101	31	3	19167051
Pubmed	LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.	BRSK2 BRSK1	1.30e-04	19	31	2	17482548
Pubmed	A genome-wide association study of the metabolic syndrome in Indian Asian men.	DYRK1A FADS2	1.30e-04	19	31	2	20694148
Pubmed	Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.	BRSK2 BRSK1	1.45e-04	20	31	2	18227155
Pubmed	SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.	BRSK2 BRSK1	1.92e-04	23	31	2	23790753
Pubmed	Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.	PRPF8 IFT172	2.10e-04	24	31	2	20705733
Pubmed	ETS-dependent regulation of a distal Gata4 cardiac enhancer.	ETV3 ERF	2.10e-04	24	31	2	22056786
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	BRSK2 DYRK1A BRSK1	2.22e-04	132	31	3	16944949
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	DYRK1A FADS2 TGM3 MAN2A1 PRPF8 SNRPA1 ETFDH	2.36e-04	1451	31	7	30550785
Pubmed	The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2.	AGO1 AGO4	2.47e-04	26	31	2	19898466
Pubmed	ETS-family genes in pancreatic development.	ETV3 ERF	3.08e-04	29	31	2	17907201
Pubmed	Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.	ETV3 ERF	3.08e-04	29	31	2	26097038
Pubmed	Cryo-EM structure of a human spliceosome activated for step 2 of splicing.	PRPF8 SNRPA1	3.29e-04	30	31	2	28076346
Pubmed	14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.	BRSK2 BRSK1	3.29e-04	30	31	2	16306228
Pubmed	STK11 is required for the normal program of ciliated cell differentiation in airways.	BRSK2 BRSK1	3.52e-04	31	31	2	31636950
Pubmed	Proteomic analysis of complexes formed by human topoisomerase I.	PRPF8 SNRPA1	3.75e-04	32	31	2	15848144
Pubmed	Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.	PRPF8 SNRPA1	3.99e-04	33	31	2	28781166
Pubmed	Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract.	PDE6B MAB21L1	4.24e-04	34	31	2	33500475
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	FADS2 AGO1 BRSK1 PRPF8 SNRPA1	4.40e-04	732	31	5	34732716
Pubmed	Defining the membrane proteome of NK cells.	DOCK10 DYNC1LI1 FADS2 AGO4 MAN2A1 PRPF8	5.07e-04	1168	31	6	19946888
Pubmed	A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.	ASPM AGO1	5.87e-04	40	31	2	20308539
Pubmed	An atlas of genetic influences on human blood metabolites.	FADS2 SPTLC3 ETFDH	6.44e-04	190	31	3	24816252
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	DYNC1LI1 AGO1 SNRPA1 IFT172	8.07e-04	475	31	4	31040226
Pubmed	Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.	FADS2 SPTLC3	8.45e-04	48	31	2	22359512
Interaction	ERFL interactions	ERFL AGO4	2.29e-06	2	31	2	int:ERFL
Interaction	NBR2 interactions	AGO4 SNRPA1	3.42e-05	6	31	2	int:NBR2
GeneFamily	Argonaute/PIWI family	AGO1 AGO4	1.79e-05	8	15	2	408
GeneFamily	ETS transcription factor family	ETV3 ERF	2.40e-04	28	15	2	534
ToppCell	facs-Spleen-nan-18m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPM FADS2 BRSK1	2.05e-04	166	31	3	8d535fab019356894b4dad3fbdbc4d2ad3e16082
ToppCell	facs-Spleen-nan-18m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPM FADS2 BRSK1	2.05e-04	166	31	3	f56b1c0d6cb5353a16a2598bda905287f16d2c39
ToppCell	facs-Spleen-nan-18m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPM FADS2 BRSK1	2.05e-04	166	31	3	a5074c96c6561273029aceb93402a7e038140f50
ToppCell	PND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPTLC3 LRRC34 CABCOCO1	2.36e-04	174	31	3	179a52d77899a929396b98d4ab2c270dd2ec708e
ToppCell	PND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPTLC3 LRRC34 CABCOCO1	2.36e-04	174	31	3	9165a1094d345328e58962f4b2a20334c3e93ead
ToppCell	Club-club-15\|World / Class top	ASPM DYRK1A ERF	2.40e-04	175	31	3	ca9d012f520f697c7450ec6958a015e20538a6a8
ToppCell	wk_20-22-Epithelial-PNS-Late_Schwann\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	BRSK2 SLC16A4 MAB21L1	2.44e-04	176	31	3	81924471d8a8c5bd8eedf294c007e25b6cd3e417
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	BRSK2 DOCK10 MAB21L1	2.52e-04	178	31	3	38ffbd01230c99f52274424ee6c172381daffc73
ToppCell	ILEUM-non-inflamed-(8)_Fibroblast-(8)_Activated_fibroblasts\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ASPM PGM2L1 MMP1	2.56e-04	179	31	3	5787ffba96918db80256ced076a455a84ba01384
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-4\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	DOCK10 FADS2 AGO1	2.61e-04	180	31	3	886ebaf9cf8992e8dd13fca799a1d1a2a9ce73d8
ToppCell	COVID-19-Epithelial-Ionocytes\|Epithelial / Condition, Lineage and Cell class	DOCK10 MAN2A1 BRSK1	2.65e-04	181	31	3	4a8d4f2709c1b25f908867f1b2fae1d2d0abf1d4
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_SCP_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	BRSK2 DOCK10 MAB21L1	2.65e-04	181	31	3	fad7ba168f541ac9d04edebc206f191e48bb7e99
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASPM FADS2 MAB21L1	2.74e-04	183	31	3	29b62dd542bc3f8df843998f577724f3818d4271
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_SCP_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	BRSK2 DOCK10 MAB21L1	2.74e-04	183	31	3	f517215ff45dec914af52dfdbc4579c19654c3aa
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	BRSK2 DOCK10 MAB21L1	2.74e-04	183	31	3	9dfb398b9995d562864fe688861a831ada0814cd
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRRC34 CABCOCO1 IFT172	2.78e-04	184	31	3	2df903924df9cb71039159416bcbe6a6614e21fe
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASPM FADS2 MAB21L1	2.82e-04	185	31	3	282b3de8850f3c21704339e8d8737b432a43441a
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	BRSK2 DOCK10 MAB21L1	2.82e-04	185	31	3	56c7a0dbf141728ac76b8c90af197719942ca67c
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	BRSK2 DOCK10 MAB21L1	2.82e-04	185	31	3	512f489daeb3b72d4578dc6f4d0ebb5f38d5bbab
ToppCell	Ciliated-cil-1\|World / Class top	LRRC34 CABCOCO1 IFT172	2.87e-04	186	31	3	283de646a0e8a322c42a714ae19db9918011146e
ToppCell	Ciliated-cil-2\|World / Class top	LRRC34 CABCOCO1 IFT172	2.92e-04	187	31	3	e2e58ba039b5355c03c3b448e750aa37b0ea6913
ToppCell	PCW_05-06-Neuronal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	BRSK2 DOCK10 MAB21L1	2.92e-04	187	31	3	03a2ed85b171c887d4f3b0f4fe2e1cb4a853e658
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPTLC3 LRRC34 CABCOCO1	2.96e-04	188	31	3	0eca3dc93724e23b71e687fc24fa9f1e89bdef6a
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPTLC3 LRRC34 CABCOCO1	2.96e-04	188	31	3	9ce3e1fffce87ad19812ecbf9b7f9935a975d676
ToppCell	Ciliated\|World / Class top	LRRC34 CABCOCO1 IFT172	2.96e-04	188	31	3	cc9178361360b5800f96516ed6a65089c144b1ce
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPTLC3 LRRC34 CABCOCO1	3.01e-04	189	31	3	b55de812043b670cbde810d7d42f45909b6d66ef
ToppCell	PND01-Epithelial-Epithelial_Airway\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPTLC3 LRRC34 CABCOCO1	3.01e-04	189	31	3	38cde34295566a4ecaf7d0a81c5a192cf17d0459
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPTLC3 LRRC34 CABCOCO1	3.01e-04	189	31	3	fe958fdf9963c2dfe270f67f0da36b3264d0017c
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPTLC3 LRRC34 CABCOCO1	3.01e-04	189	31	3	4e83e49d1265ffe507fdb72924c77c4d1c73f0bd
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPTLC3 LRRC34 CABCOCO1	3.10e-04	191	31	3	1e21de183a9c09cfb6aad3f9b948087fb6bad061
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPTLC3 LRRC34 CABCOCO1	3.10e-04	191	31	3	8688708c9183ebcb200596501dc30cc12073f151
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPTLC3 LRRC34 CABCOCO1	3.10e-04	191	31	3	96483adb97c81208aa513782550acd8a08b63866
ToppCell	Ciliated-cil-3\|World / Class top	LRRC34 CABCOCO1 IFT172	3.15e-04	192	31	3	4989ebb8812b8af1870599acd932849122c05a29
ToppCell	E16.5-Epithelial-Epithelial_Airway\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPTLC3 LRRC34 CABCOCO1	3.15e-04	192	31	3	bb7eb51bc079acacde42d8e55ba06d03eba2ea28
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPTLC3 LRRC34 CABCOCO1	3.15e-04	192	31	3	a50a6279371b3be682e334082637b7ab76b9a6e5
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRRC34 CABCOCO1 IFT172	3.25e-04	194	31	3	a46238514bca920c3e3713d23c18ba24a09e2a29
ToppCell	proximal-Hematologic-Natural_Killer_T-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK10 AGO1 ETFDH	3.30e-04	195	31	3	4d7c2c4d0130c2d46877ff6dd4584525d8f74daf
ToppCell	proximal-3-Hematologic-Natural_Killer_T\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK10 AGO1 ETFDH	3.30e-04	195	31	3	93093545bb23d2619ace029a52cffa1f673a0c2a
ToppCell	proximal-Hematologic-Natural_Killer_T\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK10 AGO1 ETFDH	3.30e-04	195	31	3	3944e4800f5d904d4efa401ce8913ec0e0781211
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BRSK2 DOCK10 MAB21L1	3.34e-04	196	31	3	e874aa82a20bb59582c8cd7f8d30b2ed02903a85
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PGM2L1 LRRC34 IFT172	3.40e-04	197	31	3	d83c61d2b5742e463122e1a98c7197a5b5b3d41b
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DYNC1LI1 FADS2 PXDNL	3.45e-04	198	31	3	0a4b19c3d5e65ecd24fc2ce80ac5276c813282c7
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DYNC1LI1 FADS2 PXDNL	3.50e-04	199	31	3	e1849505b92820a219c5a2c35492bdd55579fb48
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK10 ETV3 SPTLC3	3.50e-04	199	31	3	bbb4798d6a24e756fea744a151ba67c1bafbac9a
ToppCell	distal-2-Epithelial-Ciliated\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LRRC34 CABCOCO1 IFT172	3.50e-04	199	31	3	97b66b82c76c7bc1fcd7da7b94dd2aa2d4d70a60
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts\|LPS_only / Treatment groups by lineage, cell group, cell type	DYNC1LI1 FADS2 PXDNL	3.50e-04	199	31	3	1a0add79f4e34078b3475eb11c85a4234bda197c
ToppCell	LPS_only-Mesenchymal_fibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	DYNC1LI1 FADS2 PXDNL	3.50e-04	199	31	3	211c3a08f2d484ab7a3368006767289088f0d957
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DYNC1LI1 FADS2 PXDNL	3.55e-04	200	31	3	44a68bacdb3d5bf563bd35952176995850933a81
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DYNC1LI1 FADS2 PXDNL	3.55e-04	200	31	3	dc61016c61729f69649cfb21f6264e685ce83dea
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DYNC1LI1 FADS2 PXDNL	3.55e-04	200	31	3	3bdba9612cd7c612b76aa9abecc4a6529aabfc1c
Drug	NSC626122	ETV3 ERF	5.03e-06	3	30	2	CID000362378
Drug	AC1L9IIO	ETV3 ERF	5.03e-06	3	30	2	CID000445749
Drug	N-(2-hydroxyethyl)phenazinium	ETV3 ERF	1.01e-05	4	30	2	CID000125436
Drug	AC1LCW0P	ETV3 ERF	3.51e-05	7	30	2	CID000657096
Drug	SAR 020106	BRSK2 BRSK1	3.51e-05	7	30	2	ctd:C547874
Disease	serine/threonine-protein kinase BRSK2 measurement	BRSK2 BRSK1	3.20e-06	3	31	2	EFO_0803063
Disease	Retinitis Pigmentosa	PRPF8 PDE6B IFT172	1.78e-04	104	31	3	C0035334
Disease	visuospatial function measurement	DYRK1A LRRD1	3.42e-04	26	31	2	EFO_0803533
Disease	Global developmental delay	BRSK2 AGO1 MAB21L1	3.67e-04	133	31	3	C0557874
Disease	retinitis pigmentosa (implicated_via_orthology)	PRPF8 PDE6B	3.69e-04	27	31	2	DOID:10584 (implicated_via_orthology)
Disease	retinal degeneration (implicated_via_orthology)	PDE6B IFT172	5.53e-04	33	31	2	DOID:8466 (implicated_via_orthology)
Disease	cognitive inhibition measurement	TGM3 PXDNL	1.27e-03	50	31	2	EFO_0007969
Disease	free cholesterol to total lipids in small HDL percentage	FADS2 ETFDH	1.32e-03	51	31	2	EFO_0022285
Disease	body mass index, fasting blood glucose measurement	FADS2 ETFDH	1.32e-03	51	31	2	EFO_0004340, EFO_0004465
Disease	cholesterol to total lipids in large HDL percentage	FADS2 ETFDH	1.53e-03	55	31	2	EFO_0022234
Disease	free cholesterol to total lipids in very large HDL percentage	FADS2 ETFDH	1.53e-03	55	31	2	EFO_0022288
Disease	cholesteryl esters to total lipids in large HDL percentage	FADS2 ETFDH	1.76e-03	59	31	2	EFO_0022248
Disease	triglycerides to total lipids in large HDL percentage	FADS2 ETFDH	1.82e-03	60	31	2	EFO_0022330
Disease	free cholesterol to total lipids in medium HDL percentage	FADS2 ETFDH	1.82e-03	60	31	2	EFO_0022282

Protein segments in the cluster

Peptide	Gene	Start	Entry
RYYYNKRILHKTKGK	ERFL	101	A0A1W2PQ73
RYYYNKRILHKTKGK	ERF	86	P50548
IDYLKISLFQHYKLY	CABCOCO1	66	Q8IVU9
YYYNKRILHKTKGKR	ETV3	96	P41162
VAQYFKQKYNLQLKY	AGO1	306	Q9UL18
IKTYKHINEVYYAKK	DYRK1A	101	Q13627
YFKQKYSLQLKYPHL	AGO4	301	Q9HCK5
KAIIVIQNYYHAYKA	ASPM	1776	Q8IZT6
KKKLKYLPYNHQHEY	FADS2	251	O95864
IREYYKHLYANKLEN	nan	411	O00370
YYAAKLLQKQLNLIY	LRRC34	141	Q8IZ02
LKIKYVKYLYLDKNQ	LRRD1	161	A4D1F6
LYYFALRQAHKYKIN	MAN2A1	531	Q16706
LHDVYENKKYLYLVL	BRSK2	81	Q8IWQ3
KNIDLVYKYIVQKLY	DYNC1LI1	291	Q9Y6G9
HKYNKTNLLYSYPKL	FSIP2	626	Q5CZC0
LKQQLVKVYEKYGYH	PGM2L1	471	Q6PCE3
KYLNFATLYLKIYHL	PDE6B	211	P35913
KQNYKILHKYVALYA	IFT172	1436	Q9UG01
LYLYLYKNEIHALDK	PXDNL	101	A1KZ92
LAYQCFHALKIKKNY	ETFDH	11	Q16134
YKNQIYIYPKHLKYD	DOCK10	671	Q96BY6
LHDVYENKKYLYLVL	BRSK1	96	Q8TDC3
LVKALSYLYEKLYQK	KYAT3	106	Q6YP21
TNKKHYRLYVIYKVP	SNRPA1	126	P09661
AKLVYHLNKYYNEKC	MAB21L1	6	Q13394
VDLVQKYLEKYYNLK	MMP1	31	P03956
QIIALKKKYKAYLYI	SPTLC3	321	Q9NUV7
HPIKISYAQYEKYLK	TGM3	551	Q08188
SYQKLLKYYVLNALK	PRPF8	446	Q6P2Q9
NWIKKYHYHKSYLIL	SLC16A4	361	O15374
QKKNYYHILYELQQF	ZFYVE26	2246	Q68DK2