Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF354A ZNF628 ZNF37A KLF13 ZNF177 MYT1 ZNF540 ZSCAN5C ZNF202 ZNF808 ZNF76 ZBTB41 CHD7 ZNF101 ZNF229 ZNF354B ST18 ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	1.35e-08	1459	76	22	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF354A ZNF628 ZNF37A KLF13 ZNF177 MYT1 ZNF540 ZSCAN5C ZNF202 ZNF808 ZNF76 ZBTB41 ZNF101 ZNF229 ZNF354B ST18 ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	4.00e-08	1412	76	21	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF354A ZNF628 ZNF37A KLF13 MYT1 ZNF540 ZSCAN5C ZNF202 ZNF808 ZNF76 ZBTB41 CHD7 ZNF101 ZNF229 ZNF354B ST18 ZNF433 ZNF114	6.98e-07	1244	76	18	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF354A ZNF628 ZNF37A KLF13 MYT1 ZNF540 ZSCAN5C ZNF202 ZNF808 ZNF76 ZBTB41 CHD7 ZNF101 ZNF229 ZNF354B ST18 ZNF433 ZNF114	9.53e-07	1271	76	18	GO:0000987
GeneOntologyCellularComponent	keratohyalin granule	HRNR FLG2	1.23e-04	5	74	2	GO:0036457
Domain	zf-C2H2	ZNF354A ZNF628 ZNF37A KLF13 ZNF177 ZNF540 ZSCAN5C ZNF202 ZNF808 ZNF76 ZBTB41 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	2.72e-11	693	76	19	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF354A ZNF628 ZNF37A KLF13 ZNF177 ZNF540 ZSCAN5C ZNF202 ZNF808 ZNF76 ZBTB41 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	2.79e-11	694	76	19	IPR013087
Domain	KRAB	ZNF354A ZNF37A ZNF177 ZNF540 ZNF202 ZNF808 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	1.65e-10	358	76	14	PS50805
Domain	KRAB	ZNF354A ZNF37A ZNF177 ZNF540 ZNF202 ZNF808 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	1.65e-10	358	76	14	PF01352
Domain	ZINC_FINGER_C2H2_2	ZNF354A ZNF628 ZNF37A KLF13 ZNF177 ZNF540 ZSCAN5C ZNF202 ZNF808 ZNF76 ZBTB41 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	1.83e-10	775	76	19	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF354A ZNF628 ZNF37A KLF13 ZNF177 ZNF540 ZSCAN5C ZNF202 ZNF808 ZNF76 ZBTB41 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	1.91e-10	777	76	19	PS00028
Domain	KRAB	ZNF354A ZNF37A ZNF177 ZNF540 ZNF202 ZNF808 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	2.45e-10	369	76	14	SM00349
Domain	KRAB	ZNF354A ZNF37A ZNF177 ZNF540 ZNF202 ZNF808 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	2.54e-10	370	76	14	IPR001909
Domain	Znf_C2H2-like	ZNF354A ZNF628 ZNF37A KLF13 ZNF177 ZNF540 ZSCAN5C ZNF202 ZNF808 ZNF76 ZBTB41 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	2.87e-10	796	76	19	IPR015880
Domain	Znf_C2H2	ZNF354A ZNF628 ZNF37A KLF13 ZNF177 ZNF540 ZSCAN5C ZNF202 ZNF808 ZNF76 ZBTB41 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	3.46e-10	805	76	19	IPR007087
Domain	ZnF_C2H2	ZNF354A ZNF628 ZNF37A KLF13 ZNF177 ZNF540 ZSCAN5C ZNF202 ZNF808 ZNF76 ZBTB41 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	3.69e-10	808	76	19	SM00355
Domain	-	ZNF354A ZNF628 ZNF37A KLF13 ZNF540 ZNF202 ZNF808 ZNF76 ZBTB41 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	1.43e-09	679	76	17	3.30.160.60
Domain	zf-C2H2_6	ZNF354A ZNF540 ZNF808 ZBTB41 ZNF229 ZNF354B ZNF433 ZNF669 ZNF77 ZNF114	5.60e-07	314	76	10	PF13912
Domain	MYT1	MYT1 ST18	4.89e-05	3	76	2	PF08474
Domain	Myelin_TF	MYT1 ST18	4.89e-05	3	76	2	IPR013681
Domain	BRK	CHD9 CHD7	2.43e-04	6	76	2	SM00592
Domain	Znf_C2HC	MYT1 ST18	2.43e-04	6	76	2	IPR002515
Domain	zf-C2HC	MYT1 ST18	2.43e-04	6	76	2	PF01530
Domain	BRK_domain	CHD9 CHD7	2.43e-04	6	76	2	IPR006576
Domain	BRK	CHD9 CHD7	2.43e-04	6	76	2	PF07533
Domain	ZF_CCHHC	MYT1 ST18	3.39e-04	7	76	2	PS51802
Domain	zf-C2H2_11	ZNF354A ZNF354B	5.77e-04	9	76	2	PF16622
Domain	Helicase_C	CHD9 DDX3Y CHD7 DDX3X	9.52e-04	107	76	4	PF00271
Domain	HELICc	CHD9 DDX3Y CHD7 DDX3X	9.52e-04	107	76	4	SM00490
Domain	Helicase_C	CHD9 DDX3Y CHD7 DDX3X	9.85e-04	108	76	4	IPR001650
Domain	HELICASE_CTER	CHD9 DDX3Y CHD7 DDX3X	1.02e-03	109	76	4	PS51194
Domain	HELICASE_ATP_BIND_1	CHD9 DDX3Y CHD7 DDX3X	1.02e-03	109	76	4	PS51192
Domain	DEXDc	CHD9 DDX3Y CHD7 DDX3X	1.02e-03	109	76	4	SM00487
Domain	Helicase_ATP-bd	CHD9 DDX3Y CHD7 DDX3X	1.05e-03	110	76	4	IPR014001
Domain	Chromo_domain	CHD9 CHD7	4.26e-03	24	76	2	IPR023780
Domain	Chromo	CHD9 CHD7	4.99e-03	26	76	2	PF00385
Domain	S100_CABP	HRNR FLG2	5.37e-03	27	76	2	PS00303
Domain	S_100	HRNR FLG2	5.37e-03	27	76	2	PF01023
Domain	S100_Ca-bd_sub	HRNR FLG2	5.77e-03	28	76	2	IPR013787
Domain	CHROMO_1	CHD9 CHD7	5.77e-03	28	76	2	PS00598
Domain	S100/CaBP-9k_CS	HRNR FLG2	5.77e-03	28	76	2	IPR001751
Domain	CHROMO_2	CHD9 CHD7	5.77e-03	28	76	2	PS50013
Domain	S_100	HRNR FLG2	5.77e-03	28	76	2	SM01394
Domain	DEAD_ATP_HELICASE	DDX3Y DDX3X	7.04e-03	31	76	2	PS00039
Domain	SNF2_N	CHD9 CHD7	7.49e-03	32	76	2	IPR000330
Domain	Chromodomain-like	CHD9 CHD7	7.49e-03	32	76	2	IPR016197
Domain	SNF2_N	CHD9 CHD7	7.49e-03	32	76	2	PF00176
Domain	RNA-helicase_DEAD-box_CS	DDX3Y DDX3X	7.95e-03	33	76	2	IPR000629
Domain	Chromo/shadow_dom	CHD9 CHD7	7.95e-03	33	76	2	IPR000953
Domain	CHROMO	CHD9 CHD7	7.95e-03	33	76	2	SM00298
Domain	Q_MOTIF	DDX3Y DDX3X	9.93e-03	37	76	2	PS51195
Domain	RNA_helicase_DEAD_Q_motif	DDX3Y DDX3X	9.93e-03	37	76	2	IPR014014
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	VANGL2 SETD2 SRSF6 CLK1 PPIL4 CHD9 DDX3Y TNKS1BP1 CHD7 HRNR ARHGAP35 FLG2 ZC3H6 DDX3X	8.35e-08	1082	76	14	38697112
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF354A ZNF101 ZNF229 ZNF354B ZNF441 ZNF669 ZNF77	1.49e-07	181	76	7	37372979
Pubmed	Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.	DDX3Y DDX3X	4.71e-06	2	76	2	34437837
Pubmed	Characterization of D1Pas1, a mouse autosomal homologue of the human AZFa region DBY, as a nuclear protein in spermatogenic cells.	DDX3Y DDX3X	4.71e-06	2	76	2	11591417
Pubmed	Structural characterization and expression studies of Dby and its homologs in the mouse.	DDX3Y DDX3X	4.71e-06	2	76	2	16728723
Pubmed	An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility.	DDX3Y DDX3X	4.71e-06	2	76	2	30613052
Pubmed	Differential effects of hyperphosphorylation on splicing factor SRp55.	SRSF6 CLK1	4.71e-06	2	76	2	12549978
Pubmed	Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation.	DDX3Y DDX3X	4.71e-06	2	76	2	35588748
Pubmed	Characterization of the mouse Kid1 gene and identification of a highly related gene, Kid2.	ZNF354A ZNF354B	4.71e-06	2	76	2	10564808
Pubmed	Gene structure of the human DDX3 and chromosome mapping of its related sequences.	DDX3Y DDX3X	4.71e-06	2	76	2	11710523
Pubmed	Next generation sequencing identifies double homozygous mutations in two distinct genes (EXPH5 and COL17A1) in a patient with concomitant simplex and junctional epidermolysis bullosa.	COL17A1 EXPH5	4.71e-06	2	76	2	30016581
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	DOCK2 TBC1D15 SDF2L1 DDX3Y CHD7 DDX3X	4.81e-06	197	76	6	20811636
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SETD2 SRSF6 PHF3 PPIL4 ZNF808 DDX3Y CHD7 DDX3X TASOR2 DNMT1 NCBP3	7.03e-06	954	76	11	36373674
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	HRNR FLG2	1.41e-05	3	76	2	23403047
Pubmed	The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells.	VANGL2 FZD3	1.41e-05	3	76	2	16495441
Pubmed	Myt/NZF family transcription factors regulate neuronal differentiation of P19 cells.	MYT1 ST18	2.82e-05	4	76	2	21540077
Pubmed	Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals.	VANGL2 FZD3	2.82e-05	4	76	2	16687519
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UBR2 PHF3 STARD9 KATNIP HEATR5A ST18 DOP1B	3.12e-05	407	76	7	12693553
Pubmed	Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice.	VANGL2 FZD3	4.69e-05	5	76	2	23996638
Pubmed	Planar cell polarity pathway regulates nephrin endocytosis in developing podocytes.	VANGL2 FZD3	4.69e-05	5	76	2	23824190
Pubmed	Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals.	DDX3Y DDX3X	4.69e-05	5	76	2	8144024
Pubmed	Association between genetic variants in myosin IXB and Crohn's disease.	ATG16L1 MYO9B	4.69e-05	5	76	2	19235913
Pubmed	Planar cell polarity signaling components are a direct target of β-amyloid-associated degeneration of glutamatergic synapses.	VANGL2 FZD3	4.69e-05	5	76	2	34407949
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SETD2 SRSF6 PHF3 KIAA1958 SLCO4A1 TNKS1BP1 CHD7 ARHGAP35 DNMT1	4.81e-05	774	76	9	15302935
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	KLF13 MYT1 ZSCAN5C ZNF202 ZNF76 ZBTB41 ZC3H6 DNMT1 DOP1B	6.69e-05	808	76	9	20412781
Pubmed	Spatiotemporal expression pattern of Myt/NZF family zinc finger transcription factors during mouse nervous system development.	MYT1 ST18	7.03e-05	6	76	2	24214099
Pubmed	Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.	NEK10 CHD7 HRNR DDX3X ZNF669	7.39e-05	197	76	5	23686814
Pubmed	A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.	ATG16L1 NMNAT2 BANK1	8.66e-05	39	76	3	20962850
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	COL17A1 SRSF6 PHF3 EXPH5 PPIL4 TNKS1BP1 HRNR FLG2 DDX3X TASOR2 DNMT1	8.75e-05	1257	76	11	36526897
Pubmed	Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development.	VANGL2 FZD3	1.31e-04	8	76	2	21325504
Pubmed	Rack1 regulates cellular patterning and polarity in the mouse cochlea.	VANGL2 FZD3	1.31e-04	8	76	2	36252648
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PHF3 TNKS1BP1 CHD7 ARHGAP35 DOP1B	1.38e-04	225	76	5	12168954
Pubmed	Ciliary proteins link basal body polarization to planar cell polarity regulation.	VANGL2 FZD3	1.68e-04	9	76	2	18066062
Pubmed	Frizzled3 and Frizzled6 Cooperate with Vangl2 to Direct Cochlear Innervation by Type II Spiral Ganglion Neurons.	VANGL2 FZD3	1.68e-04	9	76	2	31462532
Pubmed	Expression of planar cell polarity genes during development of the mouse CNS.	VANGL2 FZD3	1.68e-04	9	76	2	16487141
Pubmed	A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth.	VANGL2 FZD3	1.68e-04	9	76	2	18339676
Pubmed	TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.	DDX3Y DDX3X	2.10e-04	10	76	2	18632687
Pubmed	Celsr3 is required in motor neurons to steer their axons in the hindlimb.	VANGL2 FZD3	2.10e-04	10	76	2	25108913
Pubmed	Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem.	VANGL2 FZD3	2.10e-04	10	76	2	21106844
Pubmed	The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3.	MYT1 ST18	2.10e-04	10	76	2	16920096
Pubmed	Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.	VANGL2 FZD3	2.56e-04	11	76	2	18606138
Pubmed	Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases.	VANGL2 FZD3	2.56e-04	11	76	2	19210786
Pubmed	Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.	VANGL2 FZD3	2.56e-04	11	76	2	19966784
Pubmed	Rab11a Is Essential for the Development and Integrity of the Stereocilia and Kinocilia in the Mammalian Organ of Corti.	VANGL2 FZD3	2.56e-04	11	76	2	37225424
Pubmed	A dual role for planar cell polarity genes in ciliated cells.	VANGL2 FZD3	2.56e-04	11	76	2	25024228
Pubmed	A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production.	VANGL2 FZD3	3.07e-04	12	76	2	36123354
Pubmed	Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin.	VANGL2 FZD3	3.07e-04	12	76	2	22318628
Pubmed	Microtubules enable the planar cell polarity of airway cilia.	VANGL2 FZD3	3.07e-04	12	76	2	23122850
Pubmed	Identification and Characterization of USP7 Targets in Cancer Cells.	PPIL4 DNMT1	3.62e-04	13	76	2	30367141
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	PHF3 PPIL4 CHD7 DDX3X DNMT1	3.97e-04	283	76	5	30585729
Pubmed	Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).	HRNR FLG2 DNMT1	3.97e-04	65	76	3	32120844
Pubmed	CCAT1/FABP5 promotes tumour progression through mediating fatty acid metabolism and stabilizing PI3K/AKT/mTOR signalling in lung adenocarcinoma.	ZNF628 HRNR DDX3X	3.97e-04	65	76	3	34431227
Pubmed	A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.	PLCD3 SRSF6 HRNR FLG2 DDX3X	4.17e-04	286	76	5	32041737
Pubmed	Deficiency of the planar cell polarity protein Vangl2 in podocytes affects glomerular morphogenesis and increases susceptibility to injury.	VANGL2 FZD3	4.22e-04	14	76	2	25145929
Pubmed	A non-autonomous function of the core PCP protein VANGL2 directs peripheral axon turning in the developing cochlea.	VANGL2 FZD3	4.22e-04	14	76	2	29784671
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	ATG16L1 SETD2 TBC1D15 TEPSIN SRSF6 PPIL4 KATNIP TNKS1BP1 DDX3X	4.31e-04	1038	76	9	26673895
Pubmed	Aerobic glycolysis tunes YAP/TAZ transcriptional activity.	SRSF6 HRNR FLG2 DDX3X	4.48e-04	162	76	4	25796446
Pubmed	Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.	VANGL2 FZD3	4.86e-04	15	76	2	20473291
Pubmed	Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner.	VANGL2 FZD3	4.86e-04	15	76	2	25002511
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF101 ZNF114	5.54e-04	16	76	2	8467795
Pubmed	Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity.	VANGL2 FZD3	5.54e-04	16	76	2	32460029
Pubmed	TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.	HRNR FLG2	5.54e-04	16	76	2	31823782
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	KIAA1958 TNKS1BP1 CHD7 TASOR2 DNMT1 NCBP3	5.74e-04	469	76	6	27634302
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CLMN PHF3 EXPH5 STARD9 TNKS1BP1 DDX3X DNMT1 DOP1B	5.84e-04	861	76	8	36931259
Pubmed	Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance.	VANGL2 FZD3	6.27e-04	17	76	2	21316586
Pubmed	Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.	MYT1 ST18	6.27e-04	17	76	2	17928203
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	DDX3Y DDX3X	7.05e-04	18	76	2	12023983
Pubmed	SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling.	VANGL2 FZD3	7.05e-04	18	76	2	25761772
Pubmed	Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model.	DDX3Y DDX3X	7.05e-04	18	76	2	35762573
Pubmed	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.	DOCK2 TBC1D15 DDX3Y ARHGAP35 DDX3X	7.63e-04	327	76	5	15592455
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	HRNR FLG2	9.63e-04	21	76	2	19601998
Pubmed	Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.	VANGL2 FZD3	9.63e-04	21	76	2	18701545
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	TNKS1BP1 DDX3X	9.63e-04	21	76	2	33029523
Pubmed	Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.	TNKS1BP1 DDX3X	1.06e-03	22	76	2	18377426
Pubmed	Motor neurons with axial muscle projections specified by Wnt4/5 signaling.	VANGL2 FZD3	1.06e-03	22	76	2	19285468
Pubmed	TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.	HRNR FLG2 DDX3X	1.06e-03	91	76	3	34445801
Pubmed	The small GTPase Rac1 regulates auditory hair cell morphogenesis.	VANGL2 FZD3	1.16e-03	23	76	2	20016102
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SRSF6 CLK1 PHF3 PKD1L1 DDX3X	1.18e-03	361	76	5	26167880
Pubmed	Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton's tyrosine kinase.	HRNR DDX3X	1.26e-03	24	76	2	21080425
Pubmed	The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk.	VANGL2 FZD3	1.26e-03	24	76	2	28729440
Pubmed	Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium.	VANGL2 FZD3	1.26e-03	24	76	2	19300477
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	DOCK2 ABCA12 CLMN DOP1B	1.26e-03	214	76	4	22199357
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SETD2 TBC1D15 PHF3 TNKS1BP1 ARHGAP35 DNMT1	1.29e-03	549	76	6	38280479
Pubmed	Functional coherence of the human Y chromosome.	DDX3Y DDX3X	1.37e-03	25	76	2	9381176
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	UBR2 NMNAT2 CLMN MYT1 UVSSA CHD9 KATNIP ARHGAP35 SNX29 TASOR2	1.46e-03	1489	76	10	28611215
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SETD2 TNKS1BP1 ARHGAP35	1.47e-03	102	76	3	11214970
Pubmed	MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice.	DDX3Y DDX3X	1.48e-03	26	76	2	35920200
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ATG16L1 TEPSIN CLK1 CHD9 CHD7 HRNR ST18 DOP1B SPINK14	1.53e-03	1242	76	9	30973865
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	UBR2 SRSF6 MYO9B PHF3 CHD9 DDX3Y TNKS1BP1 ZC3H6 DDX3X	1.57e-03	1247	76	9	27684187
Pubmed	Genomic analysis of mouse retinal development.	PLCD3 B4GALT7 KLF13 FZD3 CLK1 SLCO4A1 KATNIP ZNF101	1.58e-03	1006	76	8	15226823
Pubmed	Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons.	VANGL2 ST18	1.60e-03	27	76	2	31257105
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	SRSF6 PHF3 CHD7 HRNR FLG2 DDX3X	1.75e-03	583	76	6	29844126
Pubmed	Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors.	ZNF354B DNMT1	1.84e-03	29	76	2	24105743
Pubmed	Functional proteomics mapping of a human signaling pathway.	PLCD3 CPXM2 EXPH5 PPIL4 ZNF76 DDX3X	1.88e-03	591	76	6	15231748
Pubmed	Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.	TBC1D15 SRSF6 PPIL4 TASOR2 NCBP3	1.92e-03	403	76	5	35253629
Pubmed	Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling.	VANGL2 FZD3	1.97e-03	30	76	2	20630950
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	PPIL4 HRNR FLG2 DDX3X	2.07e-03	245	76	4	35652658
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	MYO9B F2RL3 ZNF177 ZNF101 CERS1 ZNF433 ZNF441 DNMT1 ZNF77	6.91e-06	797	76	9	chr19p13
Cytoband	19p13.2	ZNF177 ZNF433 ZNF441 DNMT1	5.84e-04	229	76	4	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr5q35	DOCK2 B4GALT7 ZNF354A ZNF354B	6.43e-04	235	76	4	chr5q35
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF354A ZNF628 ZNF37A KLF13 ZNF177 ZNF540 ZSCAN5C ZNF202 ZNF808 ZNF76 ZBTB41 ZNF101 ZNF229 ZNF354B ZNF433 ZNF441 ZNF669 ZNF77 ZNF114	9.43e-14	718	54	19	28
GeneFamily	Zinc fingers C2H2C-type	MYT1 ST18	2.62e-05	3	54	2	1261
GeneFamily	EF-hand domain containing\|S100 fused type protein family	HRNR FLG2	1.82e-04	7	54	2	1350
Coexpression	GSE22589_HIV_VS_HIV_AND_SIV_INFECTED_DC_DN	KLF13 ZNF202 CHD9 ZNF229 DNMT1 NCBP3	2.57e-05	200	76	6	M7801
Coexpression	GSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_48H_UP	CLEC6A COL17A1 KLF13 MYO9B STARD9 HEATR5A	2.57e-05	200	76	6	M6044
Disease	childhood medulloblastoma (implicated_via_orthology)	DDX3Y DDX3X	6.37e-06	2	75	2	DOID:3869 (implicated_via_orthology)
Disease	Sertoli cell-only syndrome (implicated_via_orthology)	DDX3Y DDX3X	3.81e-05	4	75	2	DOID:0050457 (implicated_via_orthology)
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD7	1.33e-04	7	75	2	DOID:0050834 (implicated_via_orthology)
Disease	inferior parietal cortex volume measurement	TBC1D15 CPXM2	1.06e-03	19	75	2	EFO_0010307
Disease	breast carcinoma	ZNF37A MYO9B CLK1 NEK10 MYT1 SYT14 KCNS3 ZNF101 TASOR2	1.10e-03	1019	75	9	EFO_0000305
Disease	lung cancer (is_marker_for)	SRSF6 DNMT1	4.44e-03	39	75	2	DOID:1324 (is_marker_for)
Disease	verbal-numerical reasoning measurement	DOCK2 NMNAT2 SNX29	4.57e-03	131	75	3	EFO_0008394
Disease	granulocyte percentage of myeloid white cells	UBR2 SETD2 CHD9 CHD7	4.88e-03	268	75	4	EFO_0007997

Protein segments in the cluster

Peptide	Gene	Start	Entry
SYKSGHSRSSRKHRD	VANGL2	11	Q9ULK5
HHESRKTYGQSADGA	BANK1	436	Q8NDB2
KTHVTRHAYEGSSSG	COL17A1	101	Q9UMD9
RYTHHDRKNGRSSSG	DNMT1	1456	P26358
DDYRLRHTLTGHSGK	ATG16L1	396	Q676U5
TGLYSHRHKRVGTLS	ABCA12	1466	Q86UK0
SIHHSKSHVGRGRIY	C2orf73	36	Q8N5S3
LVGAAKHGVSRTDYH	CHD7	2101	Q9P2D1
GRSGRSSYKSKHRIH	CLK1	106	P49759
LHASTVKRYGLGAHR	CPXM2	151	Q8N436
ESLKSHGRIRFYHDG	SPINK14	81	Q6IE38
SRERDGHYSNSHKSK	PPIL4	446	Q8WUA2
LGHRGHMRRSESTYS	KIAA0895L	71	Q68EN5
YEHHYKGSSRGRSKS	DDX3X	576	O00571
GYSSGHSRGTVKCRH	FLG2	141	Q5D862
ASHTEGTHDYGRRTL	KATNIP	96	O60303
YTSQKRYGLATAHHG	DOP1B	1396	Q9Y3R5
SGITTGYKTFRHLHD	B4GALT7	246	Q9UBV7
DYHLLHRSSGGNSLS	NEK10	1101	Q6ZWH5
SHSSGYRKHGSRSGQ	HRNR	721	Q86YZ3
YRKHGSRSGQSSRSE	HRNR	726	Q86YZ3
DDVGLTSYKHRHSGL	NCBP3	321	Q53F19
YSSGNRHGNITERHK	EXPH5	246	Q8NEV8
RSLGATLRHSYHEVG	KCNS3	311	Q9BQ31
YLLSRLHSSSGHGKL	TEPSIN	56	Q96N21
SHSVDYRKSAGGFIH	FOXRED2	386	Q8IWF2
ATLHTLAASGRRYGH	F2RL3	266	Q96RI0
LIGAAKHGVSRTDYH	CHD9	1971	Q3L8U1
TRTGHSLALGSLHRY	HEATR5A	906	Q86XA9
YRHHVENKGATLSRS	DOCK2	571	Q92608
KSRGGSYHRLHALAA	CERS1	226	P27544
KVSSYHGSLHRSRDG	FZD3	581	Q9NPG1
SDELARHYRTHTGEK	KLF13	211	Q9Y2Y9
HHYKGGSRGRSKSNR	DDX3Y	576	O15523
IGNTSKHTLYHGRDT	PKD1L1	1231	Q8TDX9
YHSVASALKSHRTRG	RXFP3	181	Q9NSD7
LGKYHEALSRTHNSR	SYT14	96	Q8NB59
EFVRSHGLGSHKYTL	UVSSA	291	Q2YD98
DVYGNSSGRKHRGHS	SNX29	356	Q8TEQ0
GGHSAVRKNSAYSHR	STARD9	4446	Q9P2P6
GSHSHSRSRSKDEYE	SRSF6	256	Q13247
HSSFSIRKSRLVHGY	ARHGAP35	841	Q9NRY4
KHGARGTHEVRYVSA	SLCO4A1	66	Q96BD0
HISGKYTSHRTASGC	ST18	826	O60284
KTYERGGDVSHLSHR	ABRA	116	Q8N0Z2
SGRNLLHEYKSSSHR	CLMN	76	Q96JQ2
GKRLSELHSYHSSLT	CLEC6A	51	Q6EIG7
YSGFTEHLRRHTGEK	ZNF37A	451	P17032
SYSGDLRVHSRIHTG	ZNF540	421	Q8NDQ6
YSSLREHGRTHSGEK	ZNF77	336	Q15935
YSSTLRHERTHSGEK	ZNF441	236	Q8N8Z8
GKAFSHSSYLRIHER	ZNF441	621	Q8N8Z8
HTESSHKKRTGFYRD	ZC3H6	91	P61129
STGSYLIVHKRTHTG	ZNF177	406	Q13360
LGNRSHKAAEGSHYV	ZBP1	401	Q9H171
VRLHSHDIKYGSGSG	SDF2L1	51	Q9HCN8
GYRHIHLLSKDGASL	PLCD3	761	Q8N3E9
DRIGKYESHTRVHTG	ZBTB41	371	Q5SVQ8
GQDLGKRDHHGRYSS	TNKS1BP1	906	Q9C0C2
SSLVYHRRLHTGEKS	ZNF808	776	Q8N4W9
GKGDRQRFYSDSHHL	PHF3	1916	Q92576
KERGHRGSEHLNSYE	TBC1D15	81	Q8TC07
ELGFRRGSSYSKHDS	SETD2	536	Q9BYW2
FRYGSGLLSHKRVHT	ZNF229	721	Q9UJW7
SLHRHERTHSGGKLY	ZNF101	296	Q8IZC7
LRGTSDHEYHRGVKT	TASOR2	576	Q5VWN6
SSSLRYHQRIHTGEK	ZNF354A	366	O60765
SSSLRYHQRIHTGEK	ZNF354B	366	Q96LW1
SIHRDHRYRMTTSGG	UBR2	131	Q8IWV8
SSSFRYHERTHTGEK	ZNF433	406	Q8N7K0
GKSYTRSSHLARHQK	ZNF202	431	O95125
KYRGKLAVHTRSHTG	ZSCAN5C	366	A6NGD5
FATGYGLKSHVRTHT	ZNF76	206	P36508
STSLRYHGSIHTGER	ZNF669	346	Q96BR6
RESSKYTHIRSHTGE	ZNF114	371	Q8NC26
SSALLYHQRGHTGER	ZNF628	76	Q5EBL2
RSGSTRVCHGKIYHE	KIAA1958	606	Q8N8K9
AGSSGRREQAAYHLH	MYO9B	6	Q13459
TGSGHVRGKYSRHRS	MYT1	36	Q01538
LGHISGKYASHRSAS	MYT1	901	Q01538
VHDSYGKQGLVSSRH	NMNAT2	51	Q9BZQ4