Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of G2/MI transition of meiotic cell cycle	CDC25B CDC25C	9.90e-06	3	38	2	GO:0110032
GeneOntologyBiologicalProcess	positive regulation of meiotic cell cycle phase transition	CDC25B CDC25C	1.98e-05	4	38	2	GO:1901995
GeneOntologyBiologicalProcess	regulation of G2/MI transition of meiotic cell cycle	CDC25B CDC25C	3.29e-05	5	38	2	GO:0110030
GeneOntologyBiologicalProcess	negative regulation of immature T cell proliferation in thymus	TMEM131L ERBB2	4.93e-05	6	38	2	GO:0033088
GeneOntologyBiologicalProcess	negative regulation of immature T cell proliferation	TMEM131L ERBB2	6.90e-05	7	38	2	GO:0033087
GeneOntologyBiologicalProcess	G2/MI transition of meiotic cell cycle	CDC25B CDC25C	6.90e-05	7	38	2	GO:0008315
GeneOntologyBiologicalProcess	negative regulation of T cell differentiation	TMEM131L CD74 ERBB2	1.66e-04	58	38	3	GO:0045581
GeneOntologyBiologicalProcess	meiosis I cell cycle process	MSH6 CDC25B CDC25C SLX4	1.86e-04	155	38	4	GO:0061982
GeneOntologyBiologicalProcess	regulation of meiotic cell cycle phase transition	CDC25B CDC25C	2.16e-04	12	38	2	GO:1901993
GeneOntologyBiologicalProcess	cell division	CDCA2 STX2 NCOA3 NSL1 CDC25B CDC25C CSPP1	2.47e-04	697	38	7	GO:0051301
GeneOntologyBiologicalProcess	negative regulation of T cell differentiation in thymus	TMEM131L ERBB2	2.55e-04	13	38	2	GO:0033085
GeneOntologyBiologicalProcess	negative regulation of lymphocyte differentiation	TMEM131L CD74 ERBB2	2.90e-04	70	38	3	GO:0045620
GeneOntologyBiologicalProcess	meiotic cell cycle phase transition	CDC25B CDC25C	3.42e-04	15	38	2	GO:0044771
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	PLXNA4 KIF13B ERBB2 ZFYVE27 RAPGEF2 KIF1A SKOR2	3.79e-04	748	38	7	GO:0048667
GeneOntologyBiologicalProcess	regulation of immature T cell proliferation in thymus	TMEM131L ERBB2	4.42e-04	17	38	2	GO:0033084
GeneOntologyBiologicalProcess	regulation of immature T cell proliferation	TMEM131L ERBB2	4.96e-04	18	38	2	GO:0033083
GeneOntologyBiologicalProcess	immature T cell proliferation in thymus	TMEM131L ERBB2	5.54e-04	19	38	2	GO:0033080
GeneOntologyBiologicalProcess	neuron projection morphogenesis	PLXNA4 KIF13B ERBB2 ZFYVE27 RAPGEF2 KIF1A SKOR2	5.76e-04	802	38	7	GO:0048812
GeneOntologyBiologicalProcess	immature T cell proliferation	TMEM131L ERBB2	6.15e-04	20	38	2	GO:0033079
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	PLXNA4 KIF13B ERBB2 ZFYVE27 RAPGEF2 KIF1A SKOR2	6.52e-04	819	38	7	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	PLXNA4 KIF13B ERBB2 ZFYVE27 RAPGEF2 KIF1A SKOR2	6.86e-04	826	38	7	GO:0048858
GeneOntologyBiologicalProcess	regulation of cell size	PLXNA4 ZFYVE27 RB1CC1 SLC12A7	7.61e-04	225	38	4	GO:0008361
GeneOntologyBiologicalProcess	regulation of T cell differentiation	TMEM131L CD74 ERBB2 ARID1A	7.73e-04	226	38	4	GO:0045580
GeneOntologyBiologicalProcess	regulation of neuron projection development	PLXNA4 KIF13B ZFYVE27 RAPGEF2 KIF1A SKOR2	8.19e-04	612	38	6	GO:0010975
GeneOntologyBiologicalProcess	sympathetic nervous system development	PLXNA4 ERBB2	8.89e-04	24	38	2	GO:0048485
GeneOntologyBiologicalProcess	regulation of phosphate metabolic process	CDCA2 CD74 ERBB2 RB1CC1 RAPGEF2 CDC25B CDC25C PPP6R2 TARBP2	8.96e-04	1421	38	9	GO:0019220
GeneOntologyBiologicalProcess	regulation of phosphorus metabolic process	CDCA2 CD74 ERBB2 RB1CC1 RAPGEF2 CDC25B CDC25C PPP6R2 TARBP2	9.05e-04	1423	38	9	GO:0051174
GeneOntologyBiologicalProcess	cell cycle process	CDCA2 STX2 MSH6 NSL1 ARID1A CDC25B CDC25C CSPP1 SLX4	9.90e-04	1441	38	9	GO:0022402
MousePheno	increased oxygen consumption	DOK1 NCOA3 EPRS1 ACOT11 PMCHL2	1.18e-05	121	35	5	MP:0005289
Domain	MPI_Phosphatase	CDC25B CDC25C	1.41e-05	3	41	2	IPR000751
Domain	M-inducer_phosp	CDC25B CDC25C	1.41e-05	3	41	2	PF06617
Domain	Kinesin-like_KIF1-typ	KIF13B KIF1A	2.81e-05	4	41	2	IPR022140
Domain	KIF1B	KIF13B KIF1A	2.81e-05	4	41	2	PF12423
Domain	Kinesin_assoc	KIF13B KIF1A	7.01e-05	6	41	2	PF16183
Domain	Kinesin_assoc	KIF13B KIF1A	7.01e-05	6	41	2	IPR032405
Domain	DUF3694	KIF13B KIF1A	7.01e-05	6	41	2	PF12473
Domain	Kinesin-like	KIF13B KIF1A	7.01e-05	6	41	2	IPR022164
Domain	RHOD	CDC25B CDC25C	1.06e-03	22	41	2	SM00450
Domain	PWWP	PWWP3A MSH6	1.16e-03	23	41	2	PF00855
Domain	PWWP_dom	PWWP3A MSH6	1.16e-03	23	41	2	IPR000313
Domain	RHODANESE_3	CDC25B CDC25C	1.16e-03	23	41	2	PS50206
Domain	PWWP	PWWP3A MSH6	1.26e-03	24	41	2	PS50812
Domain	Rhodanese-like_dom	CDC25B CDC25C	1.26e-03	24	41	2	IPR001763
Domain	Rhodanese	CDC25B CDC25C	1.26e-03	24	41	2	PF00581
Domain	-	CDC25B CDC25C	1.26e-03	24	41	2	3.40.250.10
Domain	FHA	KIF13B KIF1A	1.71e-03	28	41	2	SM00240
Domain	FHA_DOMAIN	KIF13B KIF1A	2.10e-03	31	41	2	PS50006
Domain	FHA	KIF13B KIF1A	2.10e-03	31	41	2	PF00498
Domain	FHA_dom	KIF13B KIF1A	2.83e-03	36	41	2	IPR000253
Domain	-	KIF13B KIF1A	2.83e-03	36	41	2	2.60.200.20
Domain	Kinesin_motor_CS	KIF13B KIF1A	3.65e-03	41	41	2	IPR019821
Domain	Kinesin-like_fam	KIF13B KIF1A	4.01e-03	43	41	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF13B KIF1A	4.20e-03	44	41	2	PS00411
Domain	-	KIF13B KIF1A	4.20e-03	44	41	2	3.40.850.10
Domain	Kinesin_motor_dom	KIF13B KIF1A	4.20e-03	44	41	2	IPR001752
Domain	Kinesin	KIF13B KIF1A	4.20e-03	44	41	2	PF00225
Domain	KINESIN_MOTOR_2	KIF13B KIF1A	4.20e-03	44	41	2	PS50067
Domain	KISc	KIF13B KIF1A	4.20e-03	44	41	2	SM00129
Domain	SMAD_FHA_domain	KIF13B KIF1A	5.82e-03	52	41	2	IPR008984
Domain	ARM-type_fold	SERAC1 ARID1A PPP6R2 AOPEP	6.36e-03	339	41	4	IPR016024
Pathway	BIOCARTA_CDC25_PATHWAY	CDC25B CDC25C	1.14e-04	8	29	2	MM1553
Pathway	BIOCARTA_CDC25_PATHWAY	CDC25B CDC25C	1.46e-04	9	29	2	M22031
Pathway	BIOCARTA_SRCRPTP_PATHWAY	CDC25B CDC25C	1.82e-04	10	29	2	MM1341
Pathway	KEGG_MEDICUS_REFERENCE_CDC25_CELL_CYCLE_G2_M	CDC25B CDC25C	1.82e-04	10	29	2	M47572
Pathway	BIOCARTA_PTC1_PATHWAY	CDC25B CDC25C	2.22e-04	11	29	2	M13022
Pathway	BIOCARTA_SRCRPTP_PATHWAY	CDC25B CDC25C	2.22e-04	11	29	2	M10994
Pathway	BIOCARTA_PTC1_PATHWAY	CDC25B CDC25C	2.22e-04	11	29	2	MM1499
Pathway	BIOCARTA_RB_PATHWAY	CDC25B CDC25C	2.66e-04	12	29	2	MM1466
Pathway	BIOCARTA_RB_PATHWAY	CDC25B CDC25C	3.14e-04	13	29	2	M18159
Pathway	BIOCARTA_G2_PATHWAY	CDC25B CDC25C	9.20e-04	22	29	2	MM1365
Pathway	BIOCARTA_VDR_PATHWAY	NCOA3 ARID1A	9.20e-04	22	29	2	MM1370
Pathway	BIOCARTA_G2_PATHWAY	CDC25B CDC25C	1.10e-03	24	29	2	M8560
Pathway	REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION	CDC25B CDC25C	1.19e-03	25	29	2	MM15379
Pathway	REACTOME_DEFECTIVE_INTRINSIC_PATHWAY_FOR_APOPTOSIS	CDC25B CDC25C	1.19e-03	25	29	2	M42527
Pathway	REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION	CDC25B CDC25C	1.19e-03	25	29	2	M808
Pathway	WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER	MSH6 ARID1A CDC25B	1.46e-03	110	29	3	M48043
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	MSH6 RB1CC1 KIF1A PPP6R2 TARBP2 SLX4	4.38e-08	167	41	6	25659891
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CDCA2 ELOA MSH6 RB1CC1 ARID1A CDC25B CDC25C SLC12A7 PPP6R2 CSPP1	2.86e-07	1049	41	10	27880917
Pubmed	Induction of potent CD4+ T cell-mediated antitumor responses by a helper HER-2/neu peptide linked to the Ii-Key moiety of the invariant chain.	CD74 ERBB2	1.36e-06	2	41	2	17634957
Pubmed	CDC25B and CDC25C overexpression in nonmelanoma skin cancer suppresses cell death.	CDC25B CDC25C	1.36e-06	2	41	2	31237025
Pubmed	Phospho-Cdc25 correlates with activating G2/M checkpoint in mouse zygotes fertilized with hydrogen peroxide-treated mouse sperm.	CDC25B CDC25C	1.36e-06	2	41	2	25012723
Pubmed	Adventitious arsenate reductase activity of the catalytic domain of the human Cdc25B and Cdc25C phosphatases.	CDC25B CDC25C	1.36e-06	2	41	2	20025242
Pubmed	The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice.	NCOA3 ERBB2	1.36e-06	2	41	2	18483252
Pubmed	The dual specificity phosphatase Cdc25B, but not the closely related Cdc25C, is capable of inhibiting cellular proliferation in a manner dependent upon its catalytic activity.	CDC25B CDC25C	1.36e-06	2	41	2	17591782
Pubmed	The distinct and developmentally regulated patterns of expression of members of the mouse Cdc25 gene family suggest differential functions during gametogenesis.	CDC25B CDC25C	1.36e-06	2	41	2	7601309
Pubmed	Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases.	CDC25B CDC25C	1.36e-06	2	41	2	15767688
Pubmed	Gender-related differences in the association between concomitant amplification of AIB1 and HER2 and clinical outcomes in glioma patients.	NCOA3 ERBB2	1.36e-06	2	41	2	30153912
Pubmed	Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes.	CDC25B CDC25C	1.36e-06	2	41	2	20500813
Pubmed	Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release Via Small Extracellular Vesicles.	ERBB2 RB1CC1	1.36e-06	2	41	2	33472043
Pubmed	Nuclear localization of cyclin B1 controls mitotic entry after DNA damage.	CDC25B CDC25C	4.06e-06	3	41	2	9585407
Pubmed	Cdc25A Is a Critical Mediator of Ischemic Neuronal Death In Vitro and In Vivo.	CDC25B CDC25C	4.06e-06	3	41	2	28607169
Pubmed	Cdc25 protein phosphatases in cell proliferation.	CDC25B CDC25C	4.06e-06	3	41	2	9141461
Pubmed	Regulation of HER2 oncogene transcription by a multifunctional coactivator/corepressor complex.	NCOA3 ERBB2	4.06e-06	3	41	2	24678732
Pubmed	Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase.	CDC25B CDC25C	4.06e-06	3	41	2	8440392
Pubmed	Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells.	CDC25B CDC25C	4.06e-06	3	41	2	26474275
Pubmed	Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells.	ARID1A CDC25C	4.06e-06	3	41	2	30097580
Pubmed	A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain.	CDC25B CDC25C	4.06e-06	3	41	2	9733650
Pubmed	Cell cycle regulation by the Cdc25 phosphatase family.	CDC25B CDC25C	4.06e-06	3	41	2	10740819
Pubmed	Dual phosphorylation controls Cdc25 phosphatases and mitotic entry.	CDC25B CDC25C	4.06e-06	3	41	2	12766774
Pubmed	HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes.	NCOA3 ERBB2	4.06e-06	3	41	2	26833126
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	NCOA3 MSH6 ERBB2 RB1CC1 CDC25B CDC25C	4.86e-06	374	41	6	19625176
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	NCOA3 MSH6 ERBB2 RB1CC1 CDC25B CDC25C	5.40e-06	381	41	6	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	NCOA3 MSH6 ERBB2 RB1CC1 CDC25B CDC25C	5.49e-06	382	41	6	19170196
Pubmed	Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion.	CDC25B CDC25C	8.12e-06	4	41	2	19273838
Pubmed	Fundamental cellular processes do not require vertebrate-specific sequences within the TATA-binding protein.	CDC25B CDC25C	8.12e-06	4	41	2	12471023
Pubmed	Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death.	CDC25B CDC25C	8.12e-06	4	41	2	22899714
Pubmed	Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells.	CDC25B CDC25C	8.12e-06	4	41	2	21283624
Pubmed	Human immunodeficiency virus type 1 Vpr induces cell cycle G2 arrest through Srk1/MK2-mediated phosphorylation of Cdc25.	CDC25B CDC25C	8.12e-06	4	41	2	18160429
Pubmed	Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins.	CDC25B CDC25C	8.12e-06	4	41	2	1836978
Pubmed	Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.	CDC25B CDC25C	8.12e-06	4	41	2	9278511
Pubmed	SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair.	MSH6 TARBP2 SLX4	8.87e-06	34	41	3	31495888
Pubmed	Genetic susceptibility to distinct bladder cancer subphenotypes.	NCOA3 MSH6 ERBB2 RB1CC1 CDC25B CDC25C	9.54e-06	421	41	6	19692168
Pubmed	Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.	CDC25B CDC25C	1.35e-05	5	41	2	15150265
Pubmed	Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein.	CDC25B CDC25C	1.35e-05	5	41	2	1828290
Pubmed	Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity.	CDC25B CDC25C	2.03e-05	6	41	2	9268380
Pubmed	Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer.	NCOA3 ERBB2	2.84e-05	7	41	2	15788656
Pubmed	Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.	CDC25B CDC25C	2.84e-05	7	41	2	11333986
Pubmed	Biochemical characterization of Cdk2-Speedy/Ringo A2.	CDC25B CDC25C	3.78e-05	8	41	2	16191191
Pubmed	Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu.	NCOA3 ERBB2	3.78e-05	8	41	2	14747462
Pubmed	Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.	CDC25B CDC25C	3.78e-05	8	41	2	20360007
Pubmed	Aerobic glycolysis tunes YAP/TAZ transcriptional activity.	EPRS1 FAM120A ARID1A MVD	4.02e-05	162	41	4	25796446
Pubmed	MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.	CDC25B CDC25C	4.86e-05	9	41	2	15629715
Pubmed	Large-scale concatenation cDNA sequencing.	DOK1 STX2 ELOA FAM120A RAPGEF2 KIF1A	5.11e-05	568	41	6	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	DOK1 STX2 ELOA FAM120A RAPGEF2 KIF1A	5.42e-05	574	41	6	8619474
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CDCA2 KIF13B ERBB2 RAPGEF2 CDC25B CDC25C CSPP1	6.00e-05	861	41	7	36931259
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	EPRS1 ELOA MSH6 RRP7A FAM120A ARID1A	7.24e-05	605	41	6	28977666
Pubmed	MARF1 regulates essential oogenic processes in mice.	CDC25B CDC25C	7.41e-05	11	41	2	22442484
Pubmed	Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program.	NCOA3 ARID1A	7.41e-05	11	41	2	18003620
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	MSH6 ERBB2 ARID1A	8.22e-05	71	41	3	28319113
Pubmed	The Cdc25 genes map to mouse chromosomes 2, 9, and 18.	CDC25B CDC25C	1.22e-04	14	41	2	8854867
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	TMEM131L MSH6 FAM120A CDC25B CDC25C KIF1A PPP6R2	1.29e-04	974	41	7	28675297
Pubmed	A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.	CDC25B CDC25C	1.41e-04	15	41	2	28094252
Pubmed	The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.	CDCA2 CD74 NSL1 CDC25B	1.48e-04	227	41	4	26410627
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	EPRS1 FAM120A RAPGEF2 CDC25B	1.61e-04	232	41	4	25515538
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	EPRS1 ELOA MSH6	1.66e-04	90	41	3	35654790
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	RAPGEF2 ARID1A CDC25C PPP6R2 CSPP1	1.74e-04	446	41	5	24255178
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	KIF13B PPP6R2 ACOT11	2.41e-04	102	41	3	9734811
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	CDCA2 ELOA MSH6 RRP7A FAM120A TARBP2	2.48e-04	759	41	6	35915203
Pubmed	The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription.	NCOA3 ELOA	2.54e-04	20	41	2	16957778
Pubmed	Charting the molecular links between driver and susceptibility genes in colorectal cancer.	MSH6 ERBB2 AOPEP	2.77e-04	107	41	3	24412244
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	NCOA3 EPRS1 MSH6 FAM120A CDC25C	3.03e-04	503	41	5	16964243
Pubmed	Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.	MSH6 SLX4	3.09e-04	22	41	2	22902628
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF13B KIF1A	4.00e-04	25	41	2	9275178
Pubmed	The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.	DOK1 ERBB2 CDC25C	5.36e-04	134	41	3	24658140
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	EPRS1 CD74 FAM120A RAPGEF2 ARID1A KIF1A SLX4	6.91e-04	1285	41	7	35914814
Pubmed	Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.	CDCA2 ELOA MSH6	7.29e-04	149	41	3	25184681
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	MSH6 ERBB2 RB1CC1 CDC25C	7.69e-04	351	41	4	20453000
Pubmed	DNA Damage Regulates Translation through β-TRCP Targeting of CReP.	RAPGEF2 CDC25B	7.87e-04	35	41	2	26091241
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	KIF13B NCOA3 ELOA CDC25B CDC25C CSPP1 TARBP2	8.14e-04	1321	41	7	27173435
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	KIF13B KIF1A	8.80e-04	37	41	2	11416179
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	EPRS1 FAM120A CDC25B SLC12A7 PPP6R2	9.65e-04	650	41	5	38777146
Pubmed	Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.	DOK1 ARID1A	9.77e-04	39	41	2	25859222
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MSH6 RRP7A FAM120A ARID1A KIF1A	9.85e-04	653	41	5	22586326
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	NCOA3 EPRS1 MSH6 FAM120A TARBP2	9.98e-04	655	41	5	35819319
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	NCOA3 MSH6 ARID1A	1.01e-03	167	41	3	20362541
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	NCOA3 MSH6 ERBB2	1.07e-03	170	41	3	19064572
Pubmed	A proteome-scale map of the SARS-CoV-2-human contactome.	ELOA ACOT11 TARBP2	1.12e-03	173	41	3	36217029
GeneFamily	Class III Cys-based CDC25 phosphatases	CDC25B CDC25C	5.96e-06	3	26	2	713
GeneFamily	PWWP domain containing	PWWP3A MSH6	4.51e-04	22	26	2	1147
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF13B KIF1A	1.98e-03	46	26	2	622
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	CDCA2 RB1CC1 CDC25C	2.17e-03	181	26	3	694
Coexpression	GSE2706_UNSTIM_VS_8H_LPS_AND_R848_DC_UP	DOK1 EPRS1 MSH6 NSL1 SLC12A7	1.41e-05	198	41	5	M4704
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	KIF13B CSPP1 ACOT11 SLX4	1.31e-05	157	41	4	4183dbed6b31ebe13ef33eb19ba6d0fb4f625953
ToppCell	(01)_Cycling_Basal_(homeostasis)\|World / shred by cell type and Timepoint	CDCA2 SERPINB8 CDC25B CDC25C	2.09e-05	177	41	4	05c57578142a6662f18b294d5cc11e6efd6b0f8e
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CDCA2 CDC25C AOPEP SLX4	2.09e-05	177	41	4	844017225e9039d1bc621a9630a30c2e9a51b36d
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDCA2 NSL1 CDC25B CDC25C	2.19e-05	179	41	4	4166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDCA2 CDC25B CDC25C SLX4	2.28e-05	181	41	4	3fe648db1cb8326066d8bde3ca1287c5c9af19bd
ToppCell	P15-Endothelial-proliferative_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CDCA2 NSL1 CDC25B CDC25C	2.28e-05	181	41	4	0c5bc1660b8fc1e905ab4230202862de5be46ebd
ToppCell	P28-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CDCA2 NSL1 CDC25B CDC25C	2.28e-05	181	41	4	e482fd116c00ff4d8db7be3c06b1bd1ffa2d479d
ToppCell	P15-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CDCA2 NSL1 CDC25B CDC25C	2.28e-05	181	41	4	f83565f09dd971c5cad2704a4a86bca0accd955e
ToppCell	P28-Endothelial-proliferative_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CDCA2 NSL1 CDC25B CDC25C	2.28e-05	181	41	4	2be3d44619adb25d339e7a27b500a56e07e8de01
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDCA2 NSL1 CDC25C SLX4	2.33e-05	182	41	4	39f9b3eb22293cc27c6e175702c77d1eeb24fdc9
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDCA2 STX2 NSL1 CDC25C	2.33e-05	182	41	4	bc6a120dedc813c58baac1428c39851a07b71ba7
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PLXNA4 CDCA2 KIF13B SORCS1	2.33e-05	182	41	4	f7f9be9c7ef8da9864d6aefe20043b26e1bb8697
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PLXNA4 KIF13B KIF1A SORCS1	2.33e-05	182	41	4	b4fc5e4f5d8440a3c9ee0a6fd0da87b43cabc8c6
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_SCP_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PLXNA4 KIF13B KIF1A SORCS1	2.38e-05	183	41	4	f517215ff45dec914af52dfdbc4579c19654c3aa
ToppCell	PCW_05-06-Neuronal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PLXNA4 KIF13B KIF1A SORCS1	2.59e-05	187	41	4	03a2ed85b171c887d4f3b0f4fe2e1cb4a853e658
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PLXNA4 NCOA3 CD74 SORCS1	2.76e-05	190	41	4	1bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell	droplet-Skin-nan-21m-Epithelial-stem_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDCA2 NSL1 CDC25B CDC25C	2.88e-05	192	41	4	96f23d6e8604d1cb24910d3118d8171b57c93e14
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDCA2 NSL1 CDC25B CDC25C	2.94e-05	193	41	4	a332dfdcc48c405020014e644aa4d14fda98cc86
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDCA2 TMEM131L CDC25B CDC25C	3.00e-05	194	41	4	06b8dc2e46f833707d5b68b324b4ff6c4d0dccf9
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLXNA4 KIF13B KIF1A SORCS1	3.06e-05	195	41	4	9fea1ddb68da83ca43dd8006c9e51295b1817f0e
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasmablast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CDCA2 NSL1 ZNF784 CDC25C	3.06e-05	195	41	4	a045fb8a377e54fb57fef1181d4c3fc15d627ef6
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLXNA4 KIF13B KIF1A SORCS1	3.12e-05	196	41	4	9afd0a7135028a446f06bb68f334e79b8f171b45
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDCA2 NSL1 CDC25B CDC25C	3.18e-05	197	41	4	f84f0ddf51208764ab56408d97035bbff562e59d
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	STX2 FAM120A RB1CC1 CSPP1	3.31e-05	199	41	4	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDCA2 TMEM131L CDC25B CDC25C	3.31e-05	199	41	4	c9d15c84b9f8c87b4ea0008be7d5efc5f45efd1a
ToppCell	primary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Ccnb1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CDCA2 NSL1 CDC25C	2.27e-04	129	41	3	ff74d159034a09f7b174da18bfb9a26936252b4c
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CDCA2 NSL1 CDC25C	3.01e-04	142	41	3	7bd05d0c0ac2dee0e6cc0f3c531f9154bf300c75
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CDCA2 NSL1 CDC25C	3.01e-04	142	41	3	92bf826827b3e3387ad326566556fc90c5c2f4d5
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P4\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CDCA2 NSL1 CDC25C	3.01e-04	142	41	3	328d08ba2712cd42bb9846ac4d7453ae165b75e2
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CDCA2 NSL1 CDC25C	3.01e-04	142	41	3	94774d3e598d074f48146b0b094705dc48af5a1f
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	STX2 RB1CC1 SORCS1	3.13e-04	144	41	3	5e948d4cb913ccd8f82262a1b4d20967aadab3ab
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CDCA2 NSL1 CDC25C	3.39e-04	148	41	3	b9d3421c2eb8e748e9508c1cbd1cb4f96e23db5a
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CDCA2 NSL1 CDC25C	3.39e-04	148	41	3	2a7671dc27afbdf6a92d976c5f2b728bd18dd609
ToppCell	droplet-Bladder-nan-3m-Hematologic-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLXNA4 CD74 CDC25C	3.60e-04	151	41	3	a7b1a60d68f0ed17022fe4c97af64f9f08d39fa3
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CDCA2 NSL1 CDC25C	3.74e-04	153	41	3	d7635f3d4831c02a94f53afc674847d5b51453be
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CDCA2 NSL1 CDC25C	3.74e-04	153	41	3	e50d20f9e553b8c3e10e187770d8abe1a43d109e
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CDCA2 NSL1 CDC25C	3.74e-04	153	41	3	54a941950bbb848077c7bd5726da9e4b3244bd38
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CDCA2 NSL1 CDC25C	3.74e-04	153	41	3	69a8550418ba0fc908a84b3b85761abb6e8ca4c0
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	KIF13B CSPP1 ACOT11	4.11e-04	158	41	3	de65af8d3b8514b17978155f31975e2347b75251
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CDCA2 CDC25C PPP6R2	4.34e-04	161	41	3	8ec923c230a7a3cce5edf2a736b3a00d607c698a
ToppCell	Ionocyte-iono-3\|World / Class top	CDCA2 NSL1 TARBP2	4.74e-04	166	41	3	9c4a780f8af46d7552077c7a0ae0ab1b2413e5d4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDCA2 CDC25C KIF1A	4.83e-04	167	41	3	50c29ea660bf07b890e4ac1a1985d0761d863dee
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDCA2 CDC25C KIF1A	4.91e-04	168	41	3	d35944fd9fea9934ce1e76b2b35d48e2300cca61
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP3_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PLXNA4 KIF1A SORCS1	5.00e-04	169	41	3	d9c3b22f62b882b8a2ea6fd9cf7afbe6d1775745
ToppCell	droplet-Lung-nan-3m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDCA2 CDC25B CDC25C	5.00e-04	169	41	3	f6a6d2f614d60395ad9b867ff1cf59eba72b04ce
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOK1 TMEM131L CDC25C	5.00e-04	169	41	3	c3d410a5e98000ba872141b62e17ef4ed3d1a8eb
ToppCell	droplet-Lung-nan-3m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDCA2 CDC25B CDC25C	5.00e-04	169	41	3	df2c9c706bfc9db2bc5726602a49f5f5a94e9481
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-Sox9_Epi-Sox9_Epi_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDCA2 CDC25B CDC25C	5.17e-04	171	41	3	621f9da0bfa09c86fc89fd26919403e94cd56d2b
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DOK1 CD74 NSL1	5.26e-04	172	41	3	76c06a968d3333441eed103abef1e636a1c3e7a1
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NSL1 SERPINB8 ZNF784	5.26e-04	172	41	3	29c8510f26527d487d0fc3543102d067cdb281a6
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDCA2 NSL1 CDC25C	5.35e-04	173	41	3	f38bf7584e08d15a6e2c116b7c3551ba475a5e14
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDCA2 TMEM131L CD74	5.35e-04	173	41	3	b7e0193fd4983cb38d1bee441f608f73ee8743b9
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-LZ_GC_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM131L NCOA3 CD74	5.44e-04	174	41	3	fde40c5d51f5380088360dc5a583eb04e518deb6
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDCA2 CDC25C AOPEP	5.44e-04	174	41	3	46cbb462173a684ceb9e680f9259dc3b133763f7
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF784 SLC12A7 SLX4	5.53e-04	175	41	3	711ace94fa9a763c6ae48171a690953f25deebe4
ToppCell	10x3'2.3-week_17-19-Neuro-stroma-schwann_cells\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ERBB2 KIF1A SORCS1	5.53e-04	175	41	3	8b010220cdfb680ec839572f4933adfb85045ea6
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDCA2 RAPGEF2 CDC25C	5.53e-04	175	41	3	3e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOK1 CD74 CDC25C	5.53e-04	175	41	3	f7d191cde68de8f3457fa62b1df53b6d0dbe5001
ToppCell	10x3'2.3-week_17-19-Neuro-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ERBB2 KIF1A SORCS1	5.53e-04	175	41	3	0b579aeadcc06be83627391c0b01bd8605fdbdf3
ToppCell	10x3'2.3-week_17-19-Neuro\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ERBB2 KIF1A SORCS1	5.53e-04	175	41	3	bbce8b1a160b414c0bf643c21c4e5e78fbccb7e1
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4\|Striatum / BrainAtlas - Mouse McCarroll V32	CDCA2 NSL1 CDC25C	5.62e-04	176	41	3	d70fdc7bc48719776ed1e7c01118385e3a21623f
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5-P5_1\|Striatum / BrainAtlas - Mouse McCarroll V32	CDCA2 NSL1 CDC25C	5.62e-04	176	41	3	a84361308e5e96f3a30246cd29e109c321ee65bf
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDCA2 NSL1 CDC25C	5.62e-04	176	41	3	45c6983ab671b0f306e7390320bd84f848e474cc
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDCA2 NSL1 CDC25C	5.72e-04	177	41	3	2b63f0529ef73e0eede9b7ef1f08b0a0426a9c82
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CDCA2 CDC25C SLX4	5.72e-04	177	41	3	26c25d10aa511b64cc7db43a8deea7b5d31bca96
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PLXNA4 KIF13B SORCS1	5.72e-04	177	41	3	59726bfd98f656fdcedf448a7e2e76a9bfad8285
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-Pre-B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM131L CD74 CDC25B	5.81e-04	178	41	3	34ef4d36ddfb1cdeaaaf5d952e1ad6dc2785ce1e
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDCA2 KIF1A ACOT11	5.91e-04	179	41	3	4f20540bfbcefe0e83812be7ea542e8bb3bf19bc
ToppCell	COVID-19-kidney-Bcells\|kidney / Disease (COVID-19 only), tissue and cell type	TMEM131L NCOA3 CD74	6.00e-04	180	41	3	5650fc7ebcdf5e0be9a217a58d36a8386d59fd1b
ToppCell	5'-Adult-SmallIntestine-Neuronal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLXNA4 KIF1A SORCS1	6.00e-04	180	41	3	5e6e38ee0758ef2342a6a821c78ed24b57bb7b11
ToppCell	5'-Adult-SmallIntestine-Neuronal-Glial_mature-Adult_Glia\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLXNA4 KIF1A SORCS1	6.00e-04	180	41	3	b88cd7ae922782176c057342d1b9eb9b8e5e7204
ToppCell	5'-Adult-SmallIntestine-Neuronal-Glial_mature\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLXNA4 KIF1A SORCS1	6.00e-04	180	41	3	ebd6e719a03f25155fa8181be19469d04d6d10a6
ToppCell	control-Lymphoid-NKT-proliferating\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CDCA2 CDC25B CDC25C	6.00e-04	180	41	3	535535a67b3f3320bad2f98b1bc98a7b0ee77840
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDCA2 LNP1 CDC25C	6.10e-04	181	41	3	e4dbc09f0210de465d8347969b301c22463a2b7d
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSL1 CDC25B CDC25C	6.10e-04	181	41	3	b203b616584cdbd0bbb0e382b2916d0bd49d3526
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDCA2 CDC25B CDC25C	6.10e-04	181	41	3	74311aac2fe27dc02a9be3bc20e0c7ef1c239049
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NSL1 CDC25B CDC25C	6.10e-04	181	41	3	c748c16fd20d1949d33ff6290dc9d9016c4dc86c
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_SCP_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PLXNA4 KIF13B SORCS1	6.10e-04	181	41	3	fad7ba168f541ac9d04edebc206f191e48bb7e99
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Proliferating_T_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDCA2 CDC25B CDC25C	6.10e-04	181	41	3	cf13bf7a531a2d40f8d778629cf2431b684f65f3
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PLXNA4 KIF13B SORCS1	6.20e-04	182	41	3	bfb725fff3d20066d8ac0a6ba2f88498fcbd876e
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDCA2 NSL1 CDC25C	6.20e-04	182	41	3	0fc45214f0b0766f69be6eff69cc4bec574023aa
ToppCell	wk_15-18-Epithelial-PNS-Early_Schwann\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KIF13B KIF1A SORCS1	6.30e-04	183	41	3	7e8366ec8117d36cec67f77dcb0e9a6032d87fcb
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T\|bone_marrow / Manually curated celltypes from each tissue	CDCA2 CDC25B CDC25C	6.30e-04	183	41	3	a48a6313f2f144586951cece97ec31f6d72361df
ToppCell	Control-T/NK_proliferative\|Control / Disease group and Cell class	CDCA2 SUN3 CDC25C	6.30e-04	183	41	3	09c2b4e630f1c338f02c1242e3598e870d6b0a28
ToppCell	367C-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	CDCA2 CDC25B CDC25C	6.30e-04	183	41	3	a716b446c2bf5aa294b8f580aa845098fae76354
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDCA2 CD74 CDC25C	6.40e-04	184	41	3	8f40093de5bb978f046d66e8f05f333686a009a4
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-B_cells-Pre-B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM131L CD74 CDC25B	6.50e-04	185	41	3	0fa7970709dc957dea95fabbd83263a0335babd5
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PLXNA4 KIF13B SORCS1	6.50e-04	185	41	3	56c7a0dbf141728ac76b8c90af197719942ca67c
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CDCA2 CDC25B CDC25C	6.50e-04	185	41	3	9d424a8608b339dd6129c58d87626678d4ec4af7
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PLXNA4 KIF13B SORCS1	6.50e-04	185	41	3	a8946379fc066903fe8f4bc9cbf693b7b424a0cd
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CDCA2 CDC25B CDC25C	6.50e-04	185	41	3	6aeae77a087d695b1e58c5f63265e7113aa2e343
ToppCell	facs-Skin-Telogen-3m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDCA2 NSL1 CDC25C	6.60e-04	186	41	3	9feef5936985e936b3d88f9d1bb012abb6468570
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	TMEM131L EPRS1 MSH6	6.60e-04	186	41	3	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF13B PWWP3A MSH6	6.60e-04	186	41	3	60830822d3de3147816693404fd03392e04c2b8e
ToppCell	normal_Pleural_Fluid-Myeloid_cells-Alveolar_Mac\|Myeloid_cells / Location, Cell class and cell subclass	ZNF784 AOPEP TARBP2	6.60e-04	186	41	3	701eea0016d69f0f9d29b613948f91239096e6c7
ToppCell	wk_20-22-Hematologic_Lymphocytic-B-pre-B-I_cell\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TMEM131L CD74 CDC25B	6.60e-04	186	41	3	d708e8f3e371c8249e8e8f7458b352af7be412e6
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	NCOA3 ARID1A PPP6R2	6.60e-04	186	41	3	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF13B PWWP3A MSH6	6.60e-04	186	41	3	37860daeecd6d412bd3797f30496a56da667fbd1
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	NCOA3 ARID1A PPP6R2	6.60e-04	186	41	3	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF13B PWWP3A MSH6	6.60e-04	186	41	3	baebeffdd426ce767190ddefc857cc78e6a58d36
Drug	Dilazep dihydrochloride [20153-98-4]; Up 200; 6uM; HL60; HT_HG-U133A	NCOA3 MSH6 ERBB2 CDC25C SLC12A7	2.55e-05	195	41	5	2333_UP
Drug	Diperodon hydrochloride [537-12-2]; Up 200; 9.2uM; HL60; HG-U133A	EPRS1 MSH6 ARID1A CDC25C ACOT11	2.55e-05	195	41	5	1575_UP
Drug	Testosterone propionate [57-85-2]; Down 200; 11.6uM; MCF7; HT_HG-U133A	STX2 RAPGEF2 CDC25C CSPP1 SNX13	2.55e-05	195	41	5	2649_DN
Drug	Chloramphenicol [56-75-7]; Down 200; 12.4uM; HL60; HT_HG-U133A	DOK1 STX2 PWWP3A RAPGEF2 TARBP2	2.55e-05	195	41	5	1837_DN
Drug	AC1L1CTC	ERBB2 CDC25B CDC25C	2.59e-05	32	41	3	CID000002055
Drug	Promethazine hydrochloride [58-33-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A	ARID1A CDC25C KIF1A CSPP1 MVD	2.68e-05	197	41	5	5317_UP
Disease	Replication Error Phenotype	MSH6 ARID1A TARBP2	1.12e-06	15	41	3	C1721098
Disease	Microsatellite Instability	MSH6 ARID1A TARBP2	1.12e-06	15	41	3	C0920269
Disease	vulva squamous cell carcinoma (is_marker_for)	CDC25B CDC25C	5.65e-06	3	41	2	DOID:2101 (is_marker_for)
Disease	endometrial hyperplasia (is_marker_for)	CDC25B CDC25C	8.42e-05	10	41	2	DOID:0080365 (is_marker_for)
Disease	breast carcinoma (is_marker_for)	NCOA3 MSH6 CDC25B	1.07e-04	66	41	3	DOID:3459 (is_marker_for)
Disease	nervous system disease (implicated_via_orthology)	KIF1A SKOR2	1.23e-04	12	41	2	DOID:863 (implicated_via_orthology)
Disease	Nasopharyngeal carcinoma	ERBB2 ARID1A	4.28e-04	22	41	2	C2931822
Disease	urinary bladder cancer (is_marker_for)	MSH6 ERBB2 CDC25B	4.47e-04	107	41	3	DOID:11054 (is_marker_for)
Disease	Intrahepatic Cholangiocarcinoma	ERBB2 ARID1A	5.10e-04	24	41	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	ERBB2 ARID1A	5.10e-04	24	41	2	C3805278
Disease	breast cancer (implicated_via_orthology)	NCOA3 MSH6	5.54e-04	25	41	2	DOID:1612 (implicated_via_orthology)
Disease	Carcinoma, Granular Cell	NCOA3 ERBB2 ARID1A	5.66e-04	116	41	3	C0205644
Disease	Adenocarcinoma, Tubular	NCOA3 ERBB2 ARID1A	5.66e-04	116	41	3	C0205645
Disease	Adenocarcinoma, Oxyphilic	NCOA3 ERBB2 ARID1A	5.66e-04	116	41	3	C0205642
Disease	Carcinoma, Cribriform	NCOA3 ERBB2 ARID1A	5.66e-04	116	41	3	C0205643
Disease	Adenocarcinoma, Basal Cell	NCOA3 ERBB2 ARID1A	5.66e-04	116	41	3	C0205641
Disease	Adenocarcinoma	NCOA3 ERBB2 ARID1A	5.66e-04	116	41	3	C0001418
Disease	Cholangiocarcinoma	ERBB2 ARID1A	5.99e-04	26	41	2	C0206698
Disease	Malignant neoplasm of breast	NCOA3 CD74 MSH6 ERBB2 RB1CC1 ARID1A SORCS1	6.32e-04	1074	41	7	C0006142
Disease	Neoplasm of uncertain or unknown behavior of ovary	MSH6 ERBB2	7.47e-04	29	41	2	C0496920
Disease	Ovarian Carcinoma	MSH6 ERBB2	7.99e-04	30	41	2	C0029925
Disease	Breast Cancer, Familial	MSH6 SLX4	7.99e-04	30	41	2	C0346153
Disease	ovarian neoplasm	DOK1 MSH6 ERBB2	8.60e-04	134	41	3	C0919267
Disease	Breast Carcinoma	NCOA3 CD74 ERBB2 RB1CC1 ARID1A	8.62e-04	538	41	5	C0678222
Disease	Malignant neoplasm of ovary	DOK1 MSH6 ERBB2	9.17e-04	137	41	3	C1140680
Disease	endometrial cancer (is_implicated_in)	MSH6 CDC25C	1.15e-03	36	41	2	DOID:1380 (is_implicated_in)
Disease	Non-Small Cell Lung Carcinoma	NCOA3 CD74 ERBB2	1.33e-03	156	41	3	C0007131
Disease	age at menarche	MSH6 RB1CC1 ARID1A SLX4 SKOR2	1.34e-03	594	41	5	EFO_0004703
Disease	Neoplasm of uncertain or unknown behavior of breast	ERBB2 ARID1A	1.49e-03	41	41	2	C0496956
Disease	Breast adenocarcinoma	ERBB2 ARID1A	1.49e-03	41	41	2	C0858252
Disease	fibrinogen measurement, tissue plasminogen activator measurement	STX2 SNX13	1.80e-03	45	41	2	EFO_0004623, EFO_0004791

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPRFRELVSEFSRMA	ERBB2	966	P04626
SRDCSRMVPAEKTRV	ACOT11	206	Q8WXI4
RRCFERTKEQMDRSS	AOPEP	796	Q8N6M6
MVRFLSDRKNPVCRE	ARID1A	2151	O14497
TPREDFRVRCTSKRA	NSL1	31	Q96IY1
RKCFDSMSRLDPRII	RB1CC1	326	Q8TDY2
PESRKERNERECLRM	LNP1	131	A1A4G5
RCERSKEPRRFASEM	PLXNA4	541	Q9HCM2
RTRARSPEICKMADN	CSPP1	26	Q1MSJ5
RMAEMARCIRERDFP	MVD	236	P53602
SERGPRMCRFIRERD	CDC25B	491	P30305
RRMRAFLACMRSDTP	FAM120A	686	Q9NZB2
AEERRDVSLKDCMRR	MSH6	1021	P52701
SERGPRMCRCLREED	CDC25C	381	P30307
RDKVMFSFEAGRRCP	DOK1	211	Q99704
ERRDERKRCHRMSPT	ELOA	176	Q14241
KFPIGRRDFDTLRCM	PMCHL2	61	Q9BQD1
VVSCRDRKDRRRSMC	CDCA2	821	Q69YH5
MHRRRSRSCREDQKP	CD74	1	P04233
EESRRREAKAPRMGT	SLC12A7	106	Q9Y666
DSDTRCAARVMARPR	PPP6R2	641	O75170
RVRPFNSREMSRDSK	KIF1A	11	Q12756
RRRLSPEKQNCRSMD	KIF13B	641	Q9NQT8
CRKMLPDRSRAARDR	PWWP3A	556	Q2TAK8
AVPCRDKSIRMRTRV	SNX13	861	Q9Y5W8
RARCPMERKSIAFRS	SERAC1	461	Q96JX3
PRDMKSCQFVAVRRD	EPRS1	1371	P07814
RFKVPESTLMDCRRQ	TMEM131L	741	A2VDJ0
RSSMRPGFEDIIRRC	NCOA3	286	Q9Y6Q9
QERSREMRALACSPK	SPATA31E1	1366	Q6ZUB1
RNSRCSRMEPRFCAD	SERPINB8	336	P50452
MRDRLPDLTACRKND	STX2	1	P32856
RRMNEAADSRDCRSP	SLX4	1456	Q8IY92
MVARRRKCAARDPED	RRP7A	1	Q9Y3A4
RASDPLMSRDIVRDC	RAPGEF2	96	Q9Y4G8
KARRAAMFFRRCSED	SUN3	6	Q8TAQ9
SSRRCGMITKREAER	SKOR2	111	Q2VWA4
EVCRARLPDSELMRR	ZFYVE27	111	Q5T4F4
PAHRKEFTMTCRVER	TARBP2	186	Q15633
GTRERDPDKATRFRM	SORCS1	141	Q8WY21
CAKPFRRSSDMRDHE	ZNF784	201	Q8NCA9