Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	IARS1 SAMHD1 VARS2 BLM LIG1 LIG4 POP1 INTS11 DCLRE1A N4BP1 MTREX TDP1 NIPBL XRCC6 MOV10 TRPT1 HELLS	9.58e-05	645	183	17	GO:0140640
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYO1D MYO7B DYNC2H1 DNAH12 STARD9 MYO1F DNAH6	1.08e-04	118	183	7	GO:0003774
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	DUSP12 NT5DC4 NAPEPLD IARS1 ASTE1 SAMHD1 VARS2 PTPN21 NT5DC1 CILP2 MTMR4 PLA1A PGAP1 POP1 INTS11 DCLRE1A N4BP1 PNPLA7 TDP1	1.62e-04	807	183	19	GO:0016788
GeneOntologyMolecularFunction	DNA ligase (ATP) activity	LIG1 LIG4	2.49e-04	3	183	2	GO:0003910
GeneOntologyMolecularFunction	DNA ligase activity	LIG1 LIG4	2.49e-04	3	183	2	GO:0003909
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DYNC2H1 DNAH12 DNAH6	5.58e-04	18	183	3	GO:0008569
GeneOntologyMolecularFunction	glutathione binding	GSTM1 GSTM3 GSTM5	5.58e-04	18	183	3	GO:0043295
GeneOntologyBiologicalProcess	cellular response to ionizing radiation	ATR NET1 ECT2 BLM LIG4 NIPBL XRCC6	4.68e-06	76	181	7	GO:0071479
Domain	GDS_CDC24_CS	NET1 ARHGEF11 ECT2 PREX2 TIAM2 PREX1	1.73e-06	39	178	6	IPR001331
Domain	RhoGEF	NET1 ARHGEF11 ECT2 PREX2 TIAM2 PREX1 FGD3	3.77e-06	68	178	7	SM00325
Domain	RhoGEF	NET1 ARHGEF11 ECT2 PREX2 TIAM2 PREX1 FGD3	4.59e-06	70	178	7	PF00621
Domain	DH_2	NET1 ARHGEF11 ECT2 PREX2 TIAM2 PREX1 FGD3	4.59e-06	70	178	7	PS50010
Domain	-	NET1 ARHGEF11 ECT2 PREX2 TIAM2 PREX1 FGD3	5.05e-06	71	178	7	1.20.900.10
Domain	DH-domain	NET1 ARHGEF11 ECT2 PREX2 TIAM2 PREX1 FGD3	5.05e-06	71	178	7	IPR000219
Domain	GST_mu	GSTM1 GSTM3 GSTM5	8.39e-06	5	178	3	IPR003081
Domain	DH_1	NET1 ARHGEF11 ECT2 PREX2 TIAM2 PREX1	2.98e-05	63	178	6	PS00741
Domain	Bromodomain_CS	BAZ2B BRD3 BAZ1A PHIP	1.01e-04	26	178	4	IPR018359
Domain	DNA_ligase_ATP-dep_C	LIG1 LIG4	2.69e-04	3	178	2	IPR012309
Domain	DNA_ligase_ATP-dep_N	LIG1 LIG4	2.69e-04	3	178	2	IPR012308
Domain	DNA_ligase_ATP-dep_cent	LIG1 LIG4	2.69e-04	3	178	2	IPR012310
Domain	DNA_LIGASE_A2	LIG1 LIG4	2.69e-04	3	178	2	PS00333
Domain	TRAM1	TRAM1L1 TRAM1	2.69e-04	3	178	2	PF08390
Domain	DNA_LIGASE_A3	LIG1 LIG4	2.69e-04	3	178	2	PS50160
Domain	DNA_ligase_ATP-dep	LIG1 LIG4	2.69e-04	3	178	2	IPR000977
Domain	DNA_ligase_ATP-dep_CS	LIG1 LIG4	2.69e-04	3	178	2	IPR016059
Domain	DNA_ligase_A_M	LIG1 LIG4	2.69e-04	3	178	2	PF01068
Domain	-	LIG1 LIG4	2.69e-04	3	178	2	1.10.3260.10
Domain	DNA_LIGASE_A1	LIG1 LIG4	2.69e-04	3	178	2	PS00697
Domain	DNA_ligase_A_C	LIG1 LIG4	2.69e-04	3	178	2	PF04679
Domain	DNA_ligase_A_N	LIG1 LIG4	2.69e-04	3	178	2	PF04675
Domain	Translocation_assoc_membrane	TRAM1L1 TRAM1	2.69e-04	3	178	2	IPR016447
Domain	TRAM1	TRAM1L1 TRAM1	2.69e-04	3	178	2	IPR013599
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH12 DNAH6	2.87e-04	14	178	3	IPR024317
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH12 DNAH6	2.87e-04	14	178	3	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH12 DNAH6	2.87e-04	14	178	3	PF08393
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DNAH12 DNAH6	2.87e-04	14	178	3	IPR011704
Domain	AAA_8	DYNC2H1 DNAH12 DNAH6	2.87e-04	14	178	3	PF12780
Domain	AAA_5	DYNC2H1 DNAH12 DNAH6	2.87e-04	14	178	3	PF07728
Domain	DHC_fam	DYNC2H1 DNAH12 DNAH6	3.56e-04	15	178	3	IPR026983
Domain	Dynein_heavy	DYNC2H1 DNAH12 DNAH6	3.56e-04	15	178	3	PF03028
Domain	Dynein_heavy_dom	DYNC2H1 DNAH12 DNAH6	3.56e-04	15	178	3	IPR004273
Domain	-	MTMR12 NET1 MYO7B PTPN21 ARHGEF11 ECT2 PREX2 TIAM2 MTMR4 ARHGAP20 PREX1 FGD3	3.83e-04	391	178	12	2.30.29.30
Domain	BROMODOMAIN_1	BAZ2B BRD3 BAZ1A PHIP	4.12e-04	37	178	4	PS00633
Domain	ARM-type_fold	ATR IFT172 HEATR4 ARMC9 UPF2 RNPEP PIK3C2G DIAPH1 LTA4H AGBL1 NIPBL	4.21e-04	339	178	11	IPR016024
Domain	Bromodomain	BAZ2B BRD3 BAZ1A PHIP	4.57e-04	38	178	4	PF00439
Domain	P-loop_NTPase	MYO1D MYO7B DYNC2H1 BLM ARHGAP5 EEF2 DNAH12 IQCA1 CIITA HNRNPUL2 TJP1 STARD9 MYO1F MTREX DNAH6 HYDIN MOV10 RAC2 HELLS	4.83e-04	848	178	19	IPR027417
Domain	Oxid_FAD_bind_N	DHCR24 D2HGDH	5.35e-04	4	178	2	IPR006094
Domain	FAD_binding_4	DHCR24 D2HGDH	5.35e-04	4	178	2	PF01565
Domain	DDT	BAZ2B BAZ1A	5.35e-04	4	178	2	PF02791
Domain	Peptidase_M1_C	RNPEP LTA4H	5.35e-04	4	178	2	IPR015211
Domain	Leuk-A4-hydro_C	RNPEP LTA4H	5.35e-04	4	178	2	SM01263
Domain	Leuk-A4-hydro_C	RNPEP LTA4H	5.35e-04	4	178	2	PF09127
Domain	BROMODOMAIN_2	BAZ2B BRD3 BAZ1A PHIP	6.13e-04	41	178	4	PS50014
Domain	Bromodomain	BAZ2B BRD3 BAZ1A PHIP	6.73e-04	42	178	4	IPR001487
Domain	BROMO	BAZ2B BRD3 BAZ1A PHIP	6.73e-04	42	178	4	SM00297
Domain	-	BAZ2B BRD3 BAZ1A PHIP	6.73e-04	42	178	4	1.20.920.10
Domain	VWC_out	FRAS1 TECTA MUC2	7.37e-04	19	178	3	SM00215
Domain	PH_dom-like	MTMR12 NET1 MYO7B PTPN21 ARHGEF11 ECT2 PREX2 TIAM2 MTMR4 ARHGAP20 PREX1 FGD3	8.16e-04	426	178	12	IPR011993
Domain	-	NAPEPLD INTS11 DCLRE1A	8.61e-04	20	178	3	3.60.15.10
Domain	Metallo-B-lactamas	NAPEPLD INTS11 DCLRE1A	8.61e-04	20	178	3	IPR001279
Domain	FerI	FER1L6 OTOF	8.86e-04	5	178	2	SM01202
Domain	FerB	FER1L6 OTOF	8.86e-04	5	178	2	SM01201
Domain	Ferlin_B-domain	FER1L6 OTOF	8.86e-04	5	178	2	IPR012561
Domain	DDT	BAZ2B BAZ1A	8.86e-04	5	178	2	SM00571
Domain	Ferlin_C	FER1L6 OTOF	8.86e-04	5	178	2	PF16165
Domain	Ferlin_C	FER1L6 OTOF	8.86e-04	5	178	2	IPR032362
Domain	FerIin_dom	FER1L6 OTOF	8.86e-04	5	178	2	IPR012968
Domain	FerI	FER1L6 OTOF	8.86e-04	5	178	2	PF08151
Domain	FerB	FER1L6 OTOF	8.86e-04	5	178	2	PF08150
Domain	DDT_dom	BAZ2B BAZ1A	8.86e-04	5	178	2	IPR018501
Domain	WHIM2_dom	BAZ2B BAZ1A	8.86e-04	5	178	2	IPR028941
Domain	WSD	BAZ2B BAZ1A	8.86e-04	5	178	2	PF15613
Domain	-	MRTFB HNRNPUL2 XRCC6	9.98e-04	21	178	3	1.10.720.30
Domain	GST_N	GSTM1 GSTM3 GSTM5	1.15e-03	22	178	3	PF02798
Domain	GST_NTER	GSTM1 GSTM3 GSTM5	1.15e-03	22	178	3	PS50404
Domain	SAP	MRTFB HNRNPUL2 XRCC6	1.15e-03	22	178	3	PF02037
Domain	SAP	MRTFB HNRNPUL2 XRCC6	1.31e-03	23	178	3	SM00513
Domain	DDT	BAZ2B BAZ1A	1.32e-03	6	178	2	PS50827
Domain	-	DHCR24 D2HGDH	1.32e-03	6	178	2	3.30.465.10
Domain	Val/Leu/Ile-tRNA-synth_edit	IARS1 VARS2	1.32e-03	6	178	2	IPR009008
Domain	FAD_PCMH	DHCR24 D2HGDH	1.32e-03	6	178	2	PS51387
Domain	CO_DH_flavot_FAD-bd_sub2	DHCR24 D2HGDH	1.32e-03	6	178	2	IPR016169
Domain	FAD-bd_2	DHCR24 D2HGDH	1.32e-03	6	178	2	IPR016166
Domain	Anticodon_1	IARS1 VARS2	1.32e-03	6	178	2	PF08264
Domain	WxxW_domain	CILP2 MUC2	1.32e-03	6	178	2	IPR025155
Domain	Mucin2_WxxW	CILP2 MUC2	1.32e-03	6	178	2	PF13330
Domain	M/V/L/I-tRNA-synth_anticd-bd	IARS1 VARS2	1.32e-03	6	178	2	IPR013155
Domain	-	IARS1 VARS2	1.32e-03	6	178	2	3.90.740.10
Domain	SAP	MRTFB HNRNPUL2 XRCC6	1.68e-03	25	178	3	PS50800
Domain	SAP_dom	MRTFB HNRNPUL2 XRCC6	1.68e-03	25	178	3	IPR003034
Domain	aa-tRNA-synth_Ia	IARS1 VARS2	1.84e-03	7	178	2	IPR002300
Domain	tRNA-synt_1	IARS1 VARS2	1.84e-03	7	178	2	PF00133
Domain	Myosin_TH1	MYO1D MYO1F	1.84e-03	7	178	2	PF06017
Domain	Myosin_TH1	MYO1D MYO1F	1.84e-03	7	178	2	IPR010926
Domain	TH1	MYO1D MYO1F	1.84e-03	7	178	2	PS51757
Domain	GST_C	GSTM1 GSTM3 GSTM5	1.88e-03	26	178	3	IPR004046
Domain	GST_C	GSTM1 GSTM3 GSTM5	1.88e-03	26	178	3	PF00043
Domain	Ubiquitin-rel_dom	MYO7B SF3A1 PTPN21 GABARAPL1 PIK3C2G ARHGAP20 USP15	1.95e-03	184	178	7	IPR029071
Domain	Glutathione_S-Trfase_N	GSTM1 GSTM3 GSTM5	2.10e-03	27	178	3	IPR004045
Domain	-	MYO7B DYNC2H1 BLM ARHGAP5 EEF2 DNAH12 IQCA1 HNRNPUL2 TJP1 MYO1F MTREX DNAH6 HYDIN MOV10 RAC2 HELLS	2.12e-03	746	178	16	3.40.50.300
Domain	Atg8	GABARAPL1 GABARAPL3	2.44e-03	8	178	2	PF02991
Domain	Atg8-like	GABARAPL1 GABARAPL3	2.44e-03	8	178	2	IPR004241
Domain	TFIIS/CRSP70_N_sub	ELOA PPP1R10	3.87e-03	10	178	2	IPR003617
Domain	TFS2N	ELOA PPP1R10	3.87e-03	10	178	2	SM00509
Domain	GST_CTER	GSTM1 GSTM3 GSTM5	4.10e-03	34	178	3	PS50405
Domain	-	IARS1 VARS2	4.69e-03	11	178	2	1.10.730.10
Domain	C2_dom	ITCH FER1L6 OTOF PIK3C2G C2CD6 UVRAG	4.91e-03	164	178	6	IPR000008
Domain	PH	NET1 ARHGEF11 ECT2 PREX2 TIAM2 ARHGAP20 PREX1 FGD3	5.28e-03	278	178	8	SM00233
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	NET1 ARHGEF11 ECT2 TIAM2 PREX1 FGD3	1.11e-05	52	138	6	MM14743
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	NET1 ARHGEF11 ECT2 TIAM2 NFKB1 PREX1 FGD3	1.93e-05	85	138	7	MM14746
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	NET1 ARHGEF11 ECT2 TIAM2 PREX1 FGD3	2.32e-05	59	138	6	M11215
Pathway	REACTOME_CDC42_GTPASE_CYCLE	ARHGEF11 ECT2 PREX2 ARHGAP5 ARHGAP20 PREX1 FGD3	3.73e-05	94	138	7	MM15598
Pathway	REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	NET1 ARHGEF11 ECT2 TIAM2 NFKB1 PREX1 FGD3	4.56e-05	97	138	7	M9400
Pathway	REACTOME_RHOB_GTPASE_CYCLE	NET1 ARHGEF11 ECT2 ARHGAP5 DIAPH1 PREX1	5.70e-05	69	138	6	MM15596
Pathway	REACTOME_RHOB_GTPASE_CYCLE	NET1 ARHGEF11 ECT2 ARHGAP5 DIAPH1 PREX1	6.19e-05	70	138	6	M41806
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	NET1 ARHGEF11 ECT2 TIAM2 PREX1 FGD3	6.19e-05	70	138	6	MM14824
Pathway	REACTOME_RHOA_GTPASE_CYCLE	NET1 ARHGEF11 ECT2 PREX2 ARHGAP5 DIAPH1 ARHGAP20 PREX1	7.67e-05	142	138	8	MM15576
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	NET1 ARHGEF11 ECT2 TIAM2 PREX1 FGD3	9.83e-05	76	138	6	M19832
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	NET1 ARHGEF11 ECT2 TIAM2 PREX1 FGD3	1.06e-04	77	138	6	MM15044
Pathway	REACTOME_RHOA_GTPASE_CYCLE	NET1 ARHGEF11 ECT2 PREX2 ARHGAP5 DIAPH1 ARHGAP20 PREX1	1.08e-04	149	138	8	M41805
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	NET1 ARHGEF11 ECT2 TIAM2 PREX1 FGD3	1.31e-04	80	138	6	M800
Pathway	REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE	LIG1 LIG4 XRCC6	3.09e-04	14	138	3	M4280
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ARHGEF11 CHN2 ECT2 PREX2 TIAM2 ARHGAP5 ARHGAP20 PREX1	3.24e-04	175	138	8	MM15599
Pathway	REACTOME_RHO_GTPASE_CYCLE	NET1 ARHGEF11 CHN2 ECT2 PREX2 TIAM2 ARHGAP5 DIAPH1 ARHGAP20 PREX1 PHIP FGD3 RAC2	3.74e-04	439	138	13	MM15595
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ARHGEF11 CHN2 ECT2 PREX2 TIAM2 ARHGAP5 ARHGAP20 PREX1	4.53e-04	184	138	8	M41809
Pathway	REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES	STAT6 DTX4 XRCC6	4.68e-04	16	138	3	M27045
Pathway	REACTOME_RHO_GTPASE_CYCLE	NET1 ARHGEF11 CHN2 ECT2 PREX2 TIAM2 ARHGAP5 DIAPH1 ARHGAP20 PREX1 PHIP FGD3 RAC2	4.73e-04	450	138	13	M27078
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	NET1 ARHGEF11 ECT2 TIAM2 NFKB1 PREX1 FGD3	4.91e-04	142	138	7	MM15431
Pathway	PID_RAC1_REG_PATHWAY	CHN2 PREX2 TIAM2 PREX1	5.01e-04	38	138	4	M241
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	ATR MYO1D DYNC2H1 IARS1 SF3A1 FN3KRP SAMHD1 RCC2 PDIA4 SART1 EEF2 KHDRBS1 RNPEP HNRNPUL2 BAZ1A STARD9 DHCR24 DNAJC11 INTS11 DIAPH1 MTREX HSD17B4 ZNF512 PC NIPBL PHIP THRAP3 XRCC6 HELLS	5.75e-10	1425	185	29	30948266
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FRAS1 MTMR12 CEP85 ATR RPS6KB1 ECT2 RCC2 LIG4 UPF2 HNRNPUL2 TRAM1 SGPL1 POP1 PAM TANC1 MTREX HSD17B4 KYNU HELLS	2.35e-09	650	185	19	38777146
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ELOA MACC1 MYO1D HKDC1 CAT BRD3 PTPN21 NEB FER1L6 PDIA4 SART1 LIG4 EEF2 KHDRBS1 BAZ1A TJP1 STARD9 DNAJC11 VPS13A C4orf51 LIMCH1 HSD17B4 DNAH6 PREX1 NIPBL THRAP3 XRCC6	1.39e-08	1442	185	27	35575683
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	ELOA ATR BRD3 NT5DC1 GINS1 BLM SART1 PPP1R10 EEF2 YJU2 KHDRBS1 RNPEP HNRNPUL2 BAZ1A DIAPH1 LTA4H MTREX NIPBL KYNU THRAP3 XRCC6 HELLS	2.73e-08	1014	185	22	32416067
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	DEAF1 ATR BAZ2B SF3A1 PHRF1 BRD3 ESCO1 RCC2 BLM SART1 PPP1R10 ZZZ3 KHDRBS1 BAZ1A TRAM1 DHCR24 POP1 INTS11 DCLRE1A MTREX PC NIPBL THRAP3 XRCC6 HELLS	2.77e-08	1294	185	25	30804502
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	MYO1D IARS1 SF3A1 RCC2 PDIA4 SART1 EEF2 KHDRBS1 HNRNPUL2 SGPL1 POP1 MTREX HSD17B4 XRCC6 MOV10	3.81e-08	469	185	15	37314180
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ELOA DEAF1 BAZ2B SF3A1 CAST RCC2 BLM SART1 PPP1R10 EEF2 ZZZ3 KHDRBS1 BAZ1A TJP1 ZNF512 PC NIPBL PHIP THRAP3 XRCC6 HELLS	4.53e-08	954	185	21	36373674
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MYO7B NEB RCC2 FER1L6 EEF2 KHDRBS1 OTOF POP1 MTREX PC THRAP3	5.82e-08	234	185	11	36243803
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MYO1D SF3A1 PHRF1 RCC2 BLM PDIA4 SART1 RNPEP TJP1 POP1 LTA4H MTREX ZNF512 NIPBL PHIP XRCC6 MOV10	9.02e-08	653	185	17	22586326
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SEL1L MACC1 NET1 PHRF1 BRD3 ARHGEF11 ECT2 RCC2 BLM GSTM3 PPP1R10 TAF8 MRTFB BAZ1A TRAM1 SGPL1 DHCR24 DNAJC11 POP1 INTS11 TANC1 LIMCH1 MTREX PREX1 NIPBL MOV10	1.17e-07	1497	185	26	31527615
Pubmed	A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5.	GSTM1 GSTM3 GSTM5	1.48e-07	3	185	3	8473333
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ELOA SYNRG DEAF1 ATR SF3A1 PHRF1 CAST BRD3 HDAC7 BLM SART1 LIG1 EEF2 POP1 LIMCH1 NIPBL THRAP3 XRCC6	1.98e-07	774	185	18	15302935
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	IARS1 SF3A1 CAST ECT2 HDAC7 GINS1 CAPN8 SART1 PPP1R10 LIG1 EEF2 UPF2 DIAPH1 XRCC6 MOV10	2.24e-07	538	185	15	28524877
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	SF3A1 BRD3 SAMHD1 ECT2 HDAC7 GSTM3 SART1 KHDRBS1 POP1 INTS11 MTREX MOV10 HELLS	2.65e-07	400	185	13	35013556
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	ELOA ITCH MYO1D IARS1 SF3A1 CAT ECT2 RCC2 GSTM1 SART1 PPP1R10 EEF2 KHDRBS1 UPF2 HNRNPUL2 TJP1 SGPL1 DNAJC11 POP1 MTREX THRAP3 XRCC6 MOV10	2.73e-07	1257	185	23	36526897
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CFAP47 BAZ2B IARS1 MYOM3 BRD3 SAMHD1 ECT2 ESCO1 PCDH17 ARHGAP5 ZZZ3 POP1 VPS13A LTA4H NCR1 ARHGAP20 XRCC6	4.82e-07	736	185	17	29676528
Pubmed	Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13.	GSTM1 GSTM3 GSTM5	5.90e-07	4	185	3	8317488
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SYNRG MTMR12 ITCH NET1 KIAA1191 PTPN21 ECT2 HDAC7 NEK4 MTMR4 TJP1 STARD9 MYCBP TANC1 LIMCH1 MTREX PC UVRAG	9.19e-07	861	185	18	36931259
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ELOA MTMR12 CEP85 MYO1D BRD3 PTPN21 BLM PDIA4 ARHGAP5 PPP1R10 MTMR4 TJP1 NFKB1 INTS11 VPS13A TANC1 HSD17B4 ZNF512 PC HELLS	9.25e-07	1049	185	20	27880917
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ITCH IARS1 CAT ECT2 NT5DC1 BLM SART1 EEF2 UPF2 HNRNPUL2 BAZ1A SGPL1 POP1 INTS11 DIAPH1 TANC1 MTREX ZNF512 NIPBL PHIP THRAP3 XRCC6 MOV10	9.69e-07	1353	185	23	29467282
Pubmed	Glutathione S-transferase variants and hypertension.	GSTM1 GSTM3 GSTM5	1.47e-06	5	185	3	18551009
Pubmed	Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1.	GSTM1 GSTM3 GSTM5	1.47e-06	5	185	3	19856098
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	ARHGEF11 ECT2 TIAM2 PREX1 FGD3	1.76e-06	38	185	5	11756498
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	ITCH SF3A1 RCC2 SART1 KHDRBS1 DIAPH1 THRAP3 XRCC6	1.85e-06	154	185	8	16055720
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	SYNRG CEP85 MYO1D IARS1 CAST PDIA4 SART1 PPP1R10 UPF2 TJP1 DCLRE1A ZNF512 PEA15 THRAP3 MOV10 HELLS	1.88e-06	724	185	16	36232890
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	ATR IARS1 SF3A1 PDIA4 SART1 EEF2 CILP2 KHDRBS1 RNPEP LIMCH1 THRAP3 XRCC6 MOV10	1.89e-06	477	185	13	31300519
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	NET1 SF3A1 CAT ARHGEF11 CHN2 ECT2 PREX2 TIAM2 PDIA4 ARHGAP5 PPP1R10 MYCBP DNAJC11 HSD17B4 ARHGAP20 USP15 PREX1 FGD3	2.20e-06	916	185	18	32203420
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	ATR SF3A1 BLM PPP1R10 KHDRBS1 MYO1F LIMCH1 MTREX NIPBL XRCC6 MOV10	2.35e-06	340	185	11	24332808
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	IARS1 SAMHD1 CHN2 RCC2 SART1 EEF2 HNRNPUL2 SGPL1 POP1 DIAPH1 HSD17B4 PC THRAP3 XRCC6 MOV10	2.59e-06	655	185	15	35819319
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	MYO1D IARS1 SF3A1 CAT RCC2 PDIA4 SART1 PPP1R10 KHDRBS1 HNRNPUL2 BAZ1A TJP1 MTREX HSD17B4 NIPBL PHIP THRAP3 XRCC6 HELLS	2.61e-06	1024	185	19	24711643
Pubmed	P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.	PREX2 PREX1 RAC2	2.93e-06	6	185	3	25538043
Pubmed	DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair.	LIG1 LIG4 TDP1	2.93e-06	6	185	3	21390131
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	ARHGEF11 ECT2 TIAM2 PREX1 FGD3	3.30e-06	43	185	5	12376548
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	ITCH MYO1D IARS1 SF3A1 SAMHD1 HDAC7 RCC2 GSTM3 SART1 EEF2 KHDRBS1 TJP1 DNAJC11 POP1 DIAPH1 LIMCH1 MTREX USP15 THRAP3 XRCC6 HELLS	3.44e-06	1247	185	21	27684187
Pubmed	P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.	PREX2 PREX1 RAC2	5.10e-06	7	185	3	21178006
Pubmed	Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.	RPS6KB1 NFKB1 PEA15	5.10e-06	7	185	3	27053111
Pubmed	Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors.	HTR2C STAT6 NFKB1 DNAH6	5.26e-06	22	185	4	33304758
Pubmed	MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.	CAST RCC2 PDIA4 EEF2 RNPEP TJP1 LTA4H HSD17B4	6.40e-06	182	185	8	30711629
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	CEP85 IARS1 SF3A1 GSTM3 LIG1 EEF2 UPF2 HNRNPUL2 DNAJC11 POP1 DIAPH1 MTREX HSD17B4 ZNF512 PC NIPBL PHIP THRAP3 XRCC6 MOV10 RAC2	8.02e-06	1318	185	21	30463901
Pubmed	Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk.	LIG1 LIG4 XRCC6	8.13e-06	8	185	3	15958648
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	ELOA SF3A1 SART1 EEF2 CIITA POP1 MTREX ZNF512 USP15 XRCC6	8.28e-06	316	185	10	31665637
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	ITCH MYO1D IARS1 SAMHD1 VARS2 PDIA4 SART1 EEF2 KHDRBS1 HNRNPUL2 TRAM1 DHCR24 DNAJC11 PREX1 XRCC6	8.73e-06	725	185	15	27025967
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	ITCH MYO1D IARS1 FN3KRP SAMHD1 BLM DHCR24 DNAJC11 PC HELLS	1.00e-05	323	185	10	24797263
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	IARS1 SAMHD1 RCC2 EEF2 KHDRBS1 UPF2 TJP1 SGPL1 PC THRAP3 XRCC6 MOV10	1.28e-05	486	185	12	30940648
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	IARS1 SF3A1 CAT ECT2 RCC2 PDIA4 SART1 EEF2 GABARAPL1 KHDRBS1 HNRNPUL2 POP1 LIMCH1 PC THRAP3 XRCC6 MOV10	1.42e-05	949	185	17	36574265
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	ELOA CEP85 SF3A1 SAMHD1 VARS2 ARHGAP5 PPP1R10 EEF2 UPF2 BAZ1A TJP1 STARD9 POP1 INTS11 LIMCH1 MTREX PC THRAP3 XRCC6 MOV10 TRPT1	1.45e-05	1371	185	21	36244648
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	CFAP47 IARS1 SF3A1 FN3KRP BLM PDIA4 EEF2 KHDRBS1 HNRNPUL2 DIAPH1 XRCC6 MOV10	1.50e-05	494	185	12	26831064
Pubmed	Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation.	TRAF3IP1 RPS6KB1 STAT6	1.73e-05	10	185	3	21945076
Pubmed	Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity.	LIG1 LIG4 XRCC6	1.73e-05	10	185	3	18990028
Pubmed	Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).	ARHGEF11 ECT2 TIAM2 PREX1 FGD3	1.74e-05	60	185	5	12787561
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	MYO1D SART1 EEF2 KHDRBS1 HNRNPUL2 TJP1 MTREX THRAP3 MOV10	1.76e-05	274	185	9	34244482
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	SF3A1 CAST RCC2 SART1 PPP1R10 EEF2 CUEDC2 KHDRBS1 UPF2 SGPL1 MYCBP POP1 N4BP1 MTREX XRCC6 MOV10 HELLS	1.90e-05	971	185	17	33306668
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	CAT GINS1 ESCO1 LIG1 NIPBL THRAP3 XRCC6	2.24e-05	157	185	7	30686591
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	ELOA SF3A1 BLM SART1 PPP1R10 MRTFB ZNF512 THRAP3 XRCC6	2.27e-05	283	185	9	30585729
Pubmed	Tissue-specific expression and subcellular distribution of murine glutathione S-transferase class kappa.	GSTM1 GSTM3 GSTM5	2.37e-05	11	185	3	15100242
Pubmed	Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2).	GSTM1 GSTM5	2.81e-05	2	185	2	2689439
Pubmed	Identification of a novel murine glutathione S-transferase class mu gene.	GSTM1 GSTM3	2.81e-05	2	185	2	9480867
Pubmed	The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer.	CYP4Z1 CYP4Z2P	2.81e-05	2	185	2	28236635
Pubmed	Susceptibility genes: GSTM1 and GSTM3 as genetic risk factors in bladder cancer.	GSTM1 GSTM3	2.81e-05	2	185	2	11173863
Pubmed	Neuroepithelial transforming gene 1 (Net1) binds to caspase activation and recruitment domain (CARD)- and membrane-associated guanylate kinase-like domain-containing (CARMA) proteins and regulates nuclear factor κB activation.	NET1 NFKB1	2.81e-05	2	185	2	22343628
Pubmed	Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.	PREX2 PREX1	2.81e-05	2	185	2	20694145
Pubmed	Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.	CYP4Z1 CYP4Z2P	2.81e-05	2	185	2	15059886
Pubmed	Pi-class glutathione-S-transferase-positive hepatocytes in aging B6C3F1 mice undergo apoptosis induced by dietary restriction.	GSTM1 GSTM5	2.81e-05	2	185	2	8909248
Pubmed	DNA methylation is associated with altered gene expression in AMD.	GSTM1 GSTM5	2.81e-05	2	185	2	22410570
Pubmed	Rationale for reclassification of a distinctive subdivision of mammalian class Mu glutathione S-transferases that are primarily expressed in testis.	GSTM1 GSTM3	2.81e-05	2	185	2	9545290
Pubmed	The association of glutathione S-transferase polymorphisms in patients with osteosarcoma: evidence from a meta-analysis.	GSTM1 GSTM3	2.81e-05	2	185	2	24689813
Pubmed	Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA.	GSTM1 GSTM3	2.81e-05	2	185	2	6822548
Pubmed	Inhibition of IgE production by docosahexaenoic acid is mediated by direct interference with STAT6 and NFκB pathway in human B cells.	STAT6 NFKB1	2.81e-05	2	185	2	20576420
Pubmed	Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.	ATR BLM	2.81e-05	2	185	2	14729972
Pubmed	Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function.	PREX1 RAC2	2.81e-05	2	185	2	17227822
Pubmed	Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.	NFKB1 MUC2	2.81e-05	2	185	2	12077118
Pubmed	Identification of a unique mu-class glutathione S-transferase in mouse spermatogenic cells.	GSTM1 GSTM3	2.81e-05	2	185	2	8607970
Pubmed	Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus.	STAT6 CIITA	2.81e-05	2	185	2	15876426
Pubmed	P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.	PREX2 PREX1	2.81e-05	2	185	2	18334636
Pubmed	Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma.	GSTM1 GSTM3	2.81e-05	2	185	2	8824514
Pubmed	Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling.	ARHGEF11 TJP1	2.81e-05	2	185	2	22665792
Pubmed	Genomic organization and characterization of the promoter region of murine GSTM2 gene.	GSTM1 GSTM5	2.81e-05	2	185	2	11404019
Pubmed	Sam68 Regulates S6K1 Alternative Splicing during Adipogenesis.	RPS6KB1 KHDRBS1	2.81e-05	2	185	2	25776557
Pubmed	P-Rex1 and P-Rex2 RacGEFs and cancer.	PREX2 PREX1	2.81e-05	2	185	2	28710285
Pubmed	Association of XRCC6 C1310G and LIG4 T9I polymorphisms of NHEJ DNA repair pathway with risk of colorectal cancer in the Polish population.	LIG4 XRCC6	2.81e-05	2	185	2	31243170
Pubmed	The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.	CYP4Z1 CYP4Z2P	2.81e-05	2	185	2	25701119
Pubmed	Genetic interactions between BLM and DNA ligase IV in human cells.	BLM LIG4	2.81e-05	2	185	2	15509577
Pubmed	Analysis of the polymorphisms in non-homologous DNA end joining (NHEJ) gene Ku70 and Ligase IV in sporadic breast cancer in women.	LIG4 XRCC6	2.81e-05	2	185	2	20496270
Pubmed	Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K.	RPS6KB1 NFKB1	2.81e-05	2	185	2	19433583
Pubmed	Can synthetic lethality approach be used with DNA repair genes for primary and secondary MDS?	LIG4 XRCC6	2.81e-05	2	185	2	31667665
Pubmed	Phylogenies of glutathione transferase families.	GSTM1 GSTM3	2.81e-05	2	185	2	16399387
Pubmed	The Major Histocompatibility Complex Class II Transactivator CIITA Inhibits the Persistent Activation of NF-κB by the Human T Cell Lymphotropic Virus Type 1 Tax-1 Oncoprotein.	CIITA NFKB1	2.81e-05	2	185	2	26792751
Pubmed	The influence of polymorphisms of glutathione S-transferases M1 and M3 on the development of human urothelial cancer.	GSTM1 GSTM3	2.81e-05	2	185	2	18569590
Pubmed	Progesterone regulation of glutathione S-transferase Mu2 expression in mouse uterine luminal epithelium during preimplantation period.	GSTM1 GSTM5	2.81e-05	2	185	2	18692819
Pubmed	Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice.	F8 MUC2	2.81e-05	2	185	2	19411636
Pubmed	GSTM1 and GSTM5 Genetic Polymorphisms and Expression in Age-Related Macular Degeneration.	GSTM1 GSTM5	2.81e-05	2	185	2	25897651
Pubmed	Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice.	KHDRBS1 NFKB1	2.81e-05	2	185	2	27996939
Pubmed	Polymorphisms in double strand break repair related genes influence radiosensitivity phenotype in lymphocytes from healthy individuals.	LIG4 XRCC6	2.81e-05	2	185	2	26974709
Pubmed	Genetic variation analysis in a follow-up study of gastric cancer precursor lesions confirms the association of MUC2 variants with the evolution of the lesions and identifies a significant association with NFKB1 and CD14.	NFKB1 MUC2	2.81e-05	2	185	2	30171605
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	IARS1 RCC2 SART1 PPP1R10 EEF2 KHDRBS1 TJP1 SGPL1 DHCR24 MTREX USP15 THRAP3 MOV10	2.83e-05	615	185	13	31048545
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CCNL2 IL12RB2 ITCH NET1 PHRF1 BRD3 EZH1 SART1 FAT1 TAF8 ZZZ3 SGPL1 INTS11 DIAPH1 TANC1 AGBL1 IQCM PHIP	3.15e-05	1116	185	18	31753913
Pubmed	ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.	SAMHD1 PDIA4 EEF2 KHDRBS1 RNPEP LTA4H XRCC6	3.20e-05	166	185	7	35687106
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	IARS1 RPS6KB1 BRD3 VARS2 KIAA1191 STAT6 LIG4 GABARAPL1 RNPEP BAZ1A INTS11 LIMCH1 HSD17B4 UVRAG THRAP3 HELLS	3.88e-05	925	185	16	28986522
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ELOA KIAA1191 PCDH17 PDIA4 NEK4 MTMR4 CUEDC2 TJP1 SGPL1 DIAPH1 DCLRE1A N4BP1 TANC1 USP15	4.19e-05	733	185	14	34672954
Pubmed	A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.	ATR LIG1 LIG4 XRCC6	4.46e-05	37	185	4	19116388
Interaction	PARP1 interactions	ELOA SF3A1 BRD3 SAMHD1 ECT2 HDAC7 BLM GSTM3 NEK4 SART1 ARHGAP5 LIG1 YJU2 KHDRBS1 BAZ1A STARD9 MYCBP NFKB1 POP1 INTS11 MTREX TDP1 ZNF512 USP15 NIPBL PHIP THRAP3 XRCC6 MOV10 HELLS	1.94e-06	1316	180	30	int:PARP1
Interaction	XRCC6 interactions	ELOA DEAF1 SF3A1 PHRF1 SAMHD1 ECT2 BLM NEK4 SART1 ARHGAP5 PPP1R10 LIG4 EEF2 MRTFB BAZ1A DIAPH1 HSD17B4 ZNF512 UVRAG THRAP3 XRCC6 MOV10 HELLS	9.33e-06	928	180	23	int:XRCC6
Interaction	CAPN11 interactions	CAPN8 MTREX DNAH6 XRCC6	1.03e-05	16	180	4	int:CAPN11
Interaction	RNF123 interactions	CFAP47 BAZ2B IARS1 MYOM3 BRD3 SAMHD1 ECT2 ESCO1 PCDH17 ARHGAP5 ZZZ3 GABARAPL1 NFKB1 POP1 VPS13A LTA4H NCR1 ARHGAP20 D2HGDH XRCC6 MOV10	1.56e-05	824	180	21	int:RNF123
Interaction	FGD4 interactions	CCNL2 MTMR12 CHN2 PREX2 PREX1 FGD3	2.28e-05	64	180	6	int:FGD4
Interaction	TECTA interactions	TECTA NEK4 PGAP1	2.39e-05	7	180	3	int:TECTA
Cytoband	1p13.3	AKNAD1 GSTM1 GSTM3 GSTM5	1.80e-04	69	185	4	1p13.3
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	NET1 ARHGEF11 ECT2 PREX2 TIAM2 PREX1 FGD3	1.22e-07	66	107	7	722
GeneFamily	DNA ligases\|Nucleotide excision repair	LIG1 LIG4	1.04e-04	3	107	2	1247
GeneFamily	Glutathione S-transferases	GSTM1 GSTM3 GSTM5	4.22e-04	25	107	3	567
GeneFamily	Ferlin family	FER1L6 OTOF	5.12e-04	6	107	2	828
GeneFamily	Myosins, class I	MYO1D MYO1F	9.49e-04	8	107	2	1097
GeneFamily	TLC domain containing	TRAM1L1 TRAM1	1.51e-03	10	107	2	1374
GeneFamily	Dynein regulatory complex	DRC7 IQCA1	1.84e-03	11	107	2	981
GeneFamily	PDZ domain containing	ARHGEF11 PREX2 TIAM2 TJP1 PREX1	2.10e-03	152	107	5	1220
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	CHN2 ARHGAP5 ARHGAP20	3.23e-03	50	107	3	721
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR12 MTMR4	3.46e-03	15	107	2	903
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	MYO1D PHRF1 PREX2 PPP1R10 HYDIN	4.44e-03	181	107	5	694
GeneFamily	Dyneins, axonemal	DNAH12 DNAH6	4.45e-03	17	107	2	536
GeneFamily	DNA helicases	XRCC6 HELLS	4.45e-03	17	107	2	1167
GeneFamily	Aminoacyl tRNA synthetases, Class I	IARS1 VARS2	5.56e-03	19	107	2	131
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HRGL3	CFAP47 CAST HOATZ STAT6 ARHGAP5 FAT1 GAREM2 IQCA1 DTX4 KCNMB1 PAM LIMCH1 DNAH6 PEA15 PREX1 HYDIN	3.47e-06	574	185	16	M39056
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	ATR BAZ2B GINS1 TDRD7 BLM FAT1 ZZZ3 UPF2 BAZ1A VPS13A LIMCH1 MTREX UVRAG PHIP	6.23e-06	466	185	14	M13522
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	ITCH ATR BAZ2B GINS1 TDRD7 BLM NEK4 FAT1 ZZZ3 UPF2 BAZ1A NFKB1 VPS13A N4BP1 MTREX USP15 NIPBL UVRAG PHIP	1.11e-05	856	185	19	M4500
Coexpression	BAE_BRCA1_TARGETS_UP	NET1 STAT6 NEK4 LIG1 TRAM1 KYNU	1.12e-05	71	185	6	M2072
Coexpression	GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_2H_UP	DYM IFT172 EXTL1 HEPACAM2 FAT1 ART4 C4orf51 IL4I1 XRCC6	1.27e-05	199	185	9	M6079
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HRGL2A	CFAP47 CAST HOATZ NLGN1 FAT1 GAREM2 IQCA1 DTX4 KCNMB1 LTA4H LIMCH1 DNAH6 PEA15 PREX1 HYDIN	2.54e-05	600	185	15	M39055
Coexpression	DESCARTES_ORGANOGENESIS_EPENDYMAL_CELL	DRC7 CFAP47 HTR2C HOATZ EFHB DNAH12 IQCA1 DNAH6 HYDIN DEUP1	3.43e-05	282	185	10	MM3642
Coexpression	DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP	ITCH BAZ2B OAS1 SAMHD1 GINS1 TDRD7 ARHGAP5 ZZZ3 GABARAPL1 N4BP1	5.77e-05	300	185	10	M14151
Coexpression	GSE42021_TREG_PLN_VS_TREG_PRECURSORS_THYMUS_UP	EXTL1 ODC1 BLM LIG4 FAT1 MRTFB DCLRE1A MUC2	8.30e-05	197	185	8	M9569
Coexpression	GSE41867_NAIVE_VS_DAY15_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN	MTMR12 ITCH IFT172 PHRF1 EZH1 NT5DC1 TGFBRAP1 THRAP3	8.90e-05	199	185	8	M9501
Coexpression	GSE31082_CD4_VS_CD8_SP_THYMOCYTE_DN	GINS1 PREX2 BLM GSTM5 CUEDC2 BAZ1A C4orf51 HELLS	8.90e-05	199	185	8	M5070
Coexpression	GSE17721_12H_VS_24H_GARDIQUIMOD_BMDC_UP	SAMHD1 TMEM106A CIITA NFKB1 MYO1F IL4I1 MOV10 TRPT1	8.90e-05	199	185	8	M4148
Coexpression	GSE20366_CD103_KLRG1_DP_VS_DN_TREG_UP	EXTL1 F8 RCC2 DNAH12 PIK3C2G DHCR24 ZNF512 PHIP	8.90e-05	199	185	8	M4341
Coexpression	GSE15930_NAIVE_VS_24H_IN_VITRO_STIM_CD8_TCELL_UP	SYNRG PHRF1 YJU2 SGPL1 DIAPH1 N4BP1 PEA15 FGD3	9.22e-05	200	185	8	M3587
Coexpression	GSE19888_CTRL_VS_TCELL_MEMBRANES_ACT_MAST_CELL_PRETREAT_A3R_INH_DN	IFT172 OAS1 SAMHD1 EFHB TDRD7 NFKB1 N4BP1 IL4I1	9.22e-05	200	185	8	M7336
Coexpression	GSE8921_UNSTIM_0H_VS_TLR1_2_STIM_MONOCYTE_12H_DN	CCNL2 SYNRG NAPEPLD CAST CAT SLC9A2 GABARAPL1 DTX4	9.22e-05	200	185	8	M6408
Coexpression	GSE17721_LPS_VS_CPG_8H_BMDC_DN	IARS1 RPS6KB1 CAT ECT2 GSTM1 GSTM5 LTA4H HSD17B4	9.22e-05	200	185	8	M4004
Coexpression	GSE11864_CSF1_IFNG_VS_CSF1_PAM3CYS_IN_MAC_UP	CEP85 GINS1 LIG1 TRAM1 MYO1F DIAPH1 UVRAG MOV10	9.22e-05	200	185	8	M3142
Coexpression	CAIRO_HEPATOBLASTOMA_CLASSES_UP	IARS1 SF3A1 RPS6KB1 ARMC9 ODC1 ECT2 GINS1 PDIA4 LIG1 PIK3C2G MYCBP LTA4H TDP1 XRCC6	1.21e-04	612	185	14	M4772
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CNTNAP3B MACC1 FRAS1 HUNK SLC9A2 PIK3C2G PGAP1 LIMCH1 FGD3 HELLS	4.51e-09	180	185	10	023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell	Epithelial-Epithelial-D_(Ciliated)\|Epithelial / shred on cell class and cell subclass (v4)	TRAF3IP1 NET1 DYNC2H1 HOATZ GSTM1 DNAH12 IQCA1 MYCBP DNAH6 HYDIN	6.85e-09	188	185	10	8f30535a32968a81a304315a49c0d90a77d36948
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CNTNAP3B MACC1 FRAS1 HUNK SLC9A2 PIK3C2G LIMCH1 FGD3 HELLS	9.34e-08	187	185	9	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 FRAS1 HUNK SLC9A2 PIK3C2G PGAP1 LIMCH1 FGD3 HELLS	1.07e-07	190	185	9	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELOA BAZ2B CAST KIAA1191 ESCO1 ARHGAP5 DIAPH1 ARHGAP20 THRAP3	1.12e-07	191	185	9	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELOA BAZ2B CAST KIAA1191 ESCO1 ARHGAP5 DIAPH1 ARHGAP20 THRAP3	1.12e-07	191	185	9	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP47 MYO1D DYNC2H1 CYP4Z2P DNAH12 TANC1 LIMCH1 DNAH6 HYDIN	1.34e-07	195	185	9	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP47 MYO1D DYNC2H1 CYP4Z2P DNAH12 TANC1 LIMCH1 DNAH6 HYDIN	1.34e-07	195	185	9	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 TRAF3IP1 DYNC2H1 IFT172 HOATZ EFHB DNAH12 DNAH6 HYDIN	1.46e-07	197	185	9	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 TRAF3IP1 DYNC2H1 IFT172 HOATZ EFHB DNAH12 DNAH6 HYDIN	1.46e-07	197	185	9	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 TRAF3IP1 DYNC2H1 IFT172 HOATZ EFHB DNAH12 DNAH6 HYDIN	1.46e-07	197	185	9	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 TRAF3IP1 DYNC2H1 IFT172 HOATZ EFHB DNAH12 DNAH6 HYDIN	1.46e-07	197	185	9	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 COL12A1 MYO7B NEB CAPN8 FAT1 PIK3C2G HYDIN	1.06e-06	184	185	8	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 COL12A1 MYO7B NEB CAPN8 FAT1 PIK3C2G HYDIN	1.06e-06	184	185	8	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 COL12A1 MYO7B NEB CAPN8 FAT1 PIK3C2G HYDIN	1.06e-06	184	185	8	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B HUNK BLM FAT1 WNT16 TANC1 ARHGAP20 AGBL1	1.15e-06	186	185	8	948815663c212c4311329d503b5991cbbbff9808
ToppCell	Ciliated-cil-2\|World / Class top	DRC7 TRAF3IP1 IFT172 HOATZ IQCA1 KCNMB1 DNAH6 HYDIN	1.20e-06	187	185	8	e2e58ba039b5355c03c3b448e750aa37b0ea6913
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 FRAS1 HUNK PIK3C2G PGAP1 LIMCH1 FGD3 HELLS	1.24e-06	188	185	8	e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CNTNAP3B MACC1 FRAS1 HUNK SLC9A2 PIK3C2G FGD3 HELLS	1.29e-06	189	185	8	3a295c215b5c18e7c673f92b7af5be523421682c
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELOA BAZ2B CAST KIAA1191 ESCO1 ARHGAP5 DIAPH1 ARHGAP20	1.40e-06	191	185	8	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 DYNC2H1 EFHB GSTM1 MRTFB IQCA1 DNAH6 HYDIN	1.51e-06	193	185	8	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 TRAF3IP1 DYNC2H1 HOATZ EFHB DNAH12 DNAH6 HYDIN	1.57e-06	194	185	8	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	BL-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 IFT172 HOATZ EFHB DNAH12 IQCA1 DNAH6 HYDIN	1.64e-06	195	185	8	07a6bcef6af93ed87df455dee624037cb75e011a
ToppCell	356C-Myeloid-Dendritic-cDC2\|356C / Donor, Lineage, Cell class and subclass (all cells)	SAMHD1 PLA1A CIITA NFKB1 KCNMB1 IL4I1 PEA15 KYNU	1.64e-06	195	185	8	4c9a2167d8cfe40dfd609c303ada5b5ef800bd8f
ToppCell	Substantia_nigra-Macroglia-CSF_related\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRC7 HKDC1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.66e-06	136	185	7	47663c5d81c766a333207a44fc5b58b07309ee76
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRC7 HKDC1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.66e-06	136	185	7	6d2e5b871f4cf8d64e6fe0be666fb3490797c635
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRC7 HKDC1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.66e-06	136	185	7	fd4269d194c7c11c6ab4383393a01efab05cbace
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRC7 HKDC1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.66e-06	136	185	7	3f6cec8d52c84191f7f6e2dd4dc47524dfd5b21b
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DRC7 HKDC1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.66e-06	136	185	7	67d736096d6b6ddb4722809557f5e987063b8d23
ToppCell	Severe_COVID-19-Epithelial-Ciliated\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	DRC7 CFAP47 HOATZ EFHB DNAH12 IQCA1 DNAH6 HYDIN	1.70e-06	196	185	8	1cdef976a754c90d18b6149d367bd64e6e99b0a9
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	CFAP47 HOATZ CYP4Z2P DNAH12 TANC1 LIMCH1 DNAH6 HYDIN	1.70e-06	196	185	8	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	BAL-Severe-Epithelial-Epithelial-Ciliated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DRC7 CFAP47 HOATZ EFHB DNAH12 IQCA1 DNAH6 HYDIN	1.70e-06	196	185	8	69f5081e06d84ec1d9695762df801a9d0df1984b
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	CFAP47 HOATZ CYP4Z2P DNAH12 TANC1 LIMCH1 DNAH6 HYDIN	1.70e-06	196	185	8	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	BAL-Severe-Epithelial-Epithelial-Ciliated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DRC7 CFAP47 HOATZ EFHB DNAH12 IQCA1 DNAH6 HYDIN	1.70e-06	196	185	8	686a5a0ddb00929842c1c98445c59edfcc9a8a04
ToppCell	BAL-Severe-Epithelial-Epithelial-Ciliated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DRC7 CFAP47 HOATZ EFHB DNAH12 IQCA1 DNAH6 HYDIN	1.70e-06	196	185	8	67aefc480714e4b8c9ae53c036efdc07ec6f94af
ToppCell	BAL-Severe-Epithelial-Epithelial-Ciliated\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	DRC7 CFAP47 HOATZ EFHB DNAH12 IQCA1 DNAH6 HYDIN	1.70e-06	196	185	8	ca56311edc6788e032e7635fa69b1e07035202b5
ToppCell	(05)_Ciliated\|World / shred by cell type and Timepoint	DRC7 TRAF3IP1 IFT172 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.77e-06	197	185	8	fee3cd16af8eea697cd64e8f64af505aaa2ac4b0
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	CAT VARS2 ODC1 PDIA4 GSTM3 PLA1A DHCR24 LTA4H	1.83e-06	198	185	8	6b6572deeca98ccb015f2aa3c5ce27de44445f74
ToppCell	LPS_only-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	CAT VARS2 ODC1 PDIA4 GSTM3 PLA1A DHCR24 LTA4H	1.90e-06	199	185	8	0447f8f53389fe7c6ddc04a97d86e74122ea16f4
ToppCell	COVID-19-lung\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SAMHD1 STAT6 CAPN8 CIITA BAZ1A MYO1F LTA4H KYNU	1.90e-06	199	185	8	155b03b859157013e9142e9248551369127d9204
ToppCell	mild-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NET1 RCC2 ARHGAP5 OTOF CIITA LIMCH1 PEA15 UVRAG	1.98e-06	200	185	8	86f585bf9066b179bbcbc703bf43f15da4a07284
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Ciliated\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	CFAP47 DYNC2H1 IFT172 HOATZ EFHB DNAH12 DNAH6 HYDIN	1.98e-06	200	185	8	6a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	COL12A1 BAZ2B HDAC7 PREX2 PCDH17 MRTFB TJP1 NIPBL	1.98e-06	200	185	8	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DRC7 HOATZ EFHB OTOF PIK3C2G DNAH6 HYDIN DEUP1	1.98e-06	200	185	8	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DRC7 CNTNAP3B ASPN LIG1 SLC9A2 PGAP1 HELLS	2.91e-06	148	185	7	18cfecd6ae20edb74f5d44ba759909df356acf3a
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3-Inhibitory_Neuron.Gad1Gad2.Six3-Adcy1_(Reticular_formation)\|Thalamus / BrainAtlas - Mouse McCarroll V32	MACC1 MEIKIN FER1L6 CILP2 C2CD6	3.28e-06	55	185	5	a911a29c2db5bf32a209a9c01afc96c9f8b401f6
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3-Inhibitory_Neuron.Gad1Gad2.Six3-Adcy1_(Reticular_formation)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	MACC1 MEIKIN FER1L6 CILP2 C2CD6	3.28e-06	55	185	5	cff015b3803f5c06afc8b22be057322e0dcbd4f2
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 COL12A1 MYO7B TECTA CAPN8 PIK3C2G HYDIN	4.87e-06	160	185	7	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 COL12A1 MYO7B TECTA CAPN8 PIK3C2G HYDIN	4.87e-06	160	185	7	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Ciliated_cells-A-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	HTR2C HOATZ EFHB PCDH17 DNAH12 HYDIN DEUP1	5.50e-06	163	185	7	43194c6127df1ce3d29242f719645de3c11fd7c0
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 HTR2C DYNC2H1 DNAH12 PGAP1 DNAH6 HYDIN	6.97e-06	169	185	7	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CNTNAP3B MACC1 FRAS1 SLC9A2 IQCA1 PIK3C2G HELLS	7.25e-06	170	185	7	928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_1\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	HOATZ GINS1 LIG1 PGAP1 POP1 DNAH6 HELLS	7.25e-06	170	185	7	aabe993c9f337b1caaeb0e64626a3920579c41b7
ToppCell	Ciliated_cells-A-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	HOATZ PCDH17 FER1L6 DNAH12 WNT16 HYDIN DEUP1	7.25e-06	170	185	7	8b7ef1464ea589886b575ebad5447b085cbdcdba
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 CEP85 TRAF3IP1 ECT2 DNAH12 DEUP1 HELLS	1.05e-05	180	185	7	0c146e80d55d18b6988dd21b1da635801bd3140c
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 CEP85 TRAF3IP1 ECT2 DNAH12 DEUP1 HELLS	1.05e-05	180	185	7	e9af22beae2f3c7fe213b4e19df84abfd2453433
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MACC1 CAT NLGN1 VARS2 GSTM3 PLA1A LTA4H	1.05e-05	180	185	7	b798a3fa2dd15b68aa4267f665559527043dcc07
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 CEP85 TRAF3IP1 ECT2 DNAH12 DEUP1 HELLS	1.05e-05	180	185	7	11455ba704ac73f69b474845136cfecec6a88349
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRAF3IP1 DYNC2H1 HOATZ EFHB DNAH12 DNAH6 HYDIN	1.05e-05	180	185	7	1f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCell	P03-Epithelial-airway_epithelial_cell-club_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DRC7 TRAF3IP1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.09e-05	181	185	7	60a91587c59029a34e7bec1255083337fe21b72a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRC7 HOATZ EFHB IQCA1 ART4 HYDIN DEUP1	1.13e-05	182	185	7	587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRC7 HOATZ EFHB IQCA1 ART4 HYDIN DEUP1	1.13e-05	182	185	7	adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MACC1 FRAS1 MYO7B HKDC1 NLGN1 FAT1 HYDIN	1.17e-05	183	185	7	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-DC2\|bone_marrow / Manually curated celltypes from each tissue	CAT SAMHD1 CIITA KCNMB1 LIMCH1 PEA15 KYNU	1.17e-05	183	185	7	f482e4fe011fa450a475034b1e25587233855bdb
ToppCell	Control-Endothelial_cells-Pulmonary_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	CNTNAP3B PREX2 PCDH17 CC2D2B MRTFB ART4 PLA1A	1.17e-05	183	185	7	46be9f96755c7b65aeac061d95d15abeb6466034
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	MACC1 MYO7B MYOM3 NLGN1 FAT1 VPS13A HYDIN	1.21e-05	184	185	7	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	Ciliated-cil-1\|World / Class top	DRC7 TRAF3IP1 IFT172 HOATZ IQCA1 MYCBP DNAH6	1.30e-05	186	185	7	283de646a0e8a322c42a714ae19db9918011146e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 MYO7B MYOM3 NLGN1 FAT1 IQCA1 HYDIN	1.30e-05	186	185	7	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	COVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	CNTNAP3B F8 PREX2 PCDH17 MRTFB ART4 PLA1A	1.35e-05	187	185	7	2d20193a6cacdfa4877457c97b0077408942186c
ToppCell	PND14-Epithelial-Epithelial_Airway\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DRC7 TRAF3IP1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.35e-05	187	185	7	1399c703505211c510b3f14c7a2aa9930566c473
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GSTM1 ARHGAP5 PPP1R10 UPF2 BAZ1A DIAPH1 NIPBL	1.35e-05	187	185	7	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	Ciliated\|World / Class top	DRC7 TRAF3IP1 IFT172 HOATZ IQCA1 DNAH6 HYDIN	1.39e-05	188	185	7	cc9178361360b5800f96516ed6a65089c144b1ce
ToppCell	Adult-Epithelial-ciliated_cell-D231\|Adult / Lineage, Cell type, age group and donor	DRC7 CFAP47 HOATZ EFHB DNAH12 DNAH6 HYDIN	1.39e-05	188	185	7	34b11f72ca73153d02edcd09b38983ad1a504659
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	IARS1 HKDC1 ARMC9 NLGN1 CAPN8 DHCR24 AGBL1	1.39e-05	188	185	7	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DRC7 CFAP47 HOATZ EFHB DNAH12 DNAH6 HYDIN	1.39e-05	188	185	7	2b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCell	COPD-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	IL12RB2 CYP4Z2P DNAH12 TANC1 NCR1 HYDIN HELLS	1.39e-05	188	185	7	186fe1ea328c942910190a4240262c0d8642ea3b
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DRC7 TRAF3IP1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.44e-05	189	185	7	b55de812043b670cbde810d7d42f45909b6d66ef
ToppCell	PND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DRC7 TRAF3IP1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.44e-05	189	185	7	02c6128a9ab5818e0881dcadafdad5f08b9a67cf
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Ciliated_1\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	CFAP47 HOATZ EFHB DNAH12 IQCA1 DNAH6 HYDIN	1.44e-05	189	185	7	dc440015949a768188c67661b6be63b1ead1a0f0
ToppCell	PND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DRC7 TRAF3IP1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.44e-05	189	185	7	164ea92ff6a1aa2ead1c9b8f64f99a9d65437232
ToppCell	Control-Endothelial-VE_Venous\|World / Disease state, Lineage and Cell class	CNTNAP3B PREX2 PCDH17 MRTFB ART4 PLA1A TANC1	1.44e-05	189	185	7	f83f7521e377ded1522639e9a35c98b3e2725bac
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NAPEPLD EVC NLGN1 HUNK FAT1 DNAH6 HYDIN	1.44e-05	189	185	7	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B HUNK BLM WNT16 TANC1 ARHGAP20 AGBL1	1.44e-05	189	185	7	78cf414b98bcb19deb934409acddaad1cd51b67f
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DRC7 CFAP47 HOATZ EFHB DNAH12 DNAH6 HYDIN	1.44e-05	189	185	7	a3cd4c2da4feb9bdcd8957f3e344d095da1367b8
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DRC7 CFAP47 HOATZ EFHB DNAH12 DNAH6 HYDIN	1.44e-05	189	185	7	68a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCell	PND10-Epithelial-Epithelial_Airway\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DRC7 TRAF3IP1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.44e-05	189	185	7	407d8a59969d83f014600aae1a55092283a13970
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 FRAS1 HUNK SLC9A2 PIK3C2G LIMCH1 HELLS	1.44e-05	189	185	7	bfc76a72b600d641c8fe58346e5d8986c34f3981
ToppCell	Epithelial-D_(Ciliated)\|World / shred on cell class and cell subclass (v4)	DRC7 TRAF3IP1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.44e-05	189	185	7	0bf560b595c7a8450a46bc821b742b67965bd9f9
ToppCell	PND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DRC7 TRAF3IP1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.44e-05	189	185	7	a85099bd598a27ee64ee0664d051d89fa8d62fc9
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DRC7 TRAF3IP1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.44e-05	189	185	7	4e83e49d1265ffe507fdb72924c77c4d1c73f0bd
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DRC7 CFAP47 HOATZ EFHB DNAH12 DNAH6 HYDIN	1.44e-05	189	185	7	93b1026bb1ba759e5704561c9a5de14a30c08894
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	IL12RB2 DEAF1 NET1 ESCO1 PGAP1 N4BP1 PREX1	1.49e-05	190	185	7	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	PND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DRC7 TRAF3IP1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.49e-05	190	185	7	35248a8be476ea8d06d67c3d98a25be1f7c150b7
ToppCell	PND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DRC7 TRAF3IP1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.49e-05	190	185	7	5f5206f9e725070d865f4c891ff08bb750e58582
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 TRAF3IP1 HOATZ ECT2 DNAH12 DEUP1 HELLS	1.49e-05	190	185	7	827a1f4e4ac4beada262f4fb965dd74a447a8f4f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B HUNK BLM SLC9A2 TANC1 ARHGAP20 AGBL1	1.49e-05	190	185	7	26843ec1d19ac85a50990705353b802745d33e4d
ToppCell	Fetal_29-31_weeks-Immune-monocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SAMHD1 CIITA MYO1F DIAPH1 IL4I1 PREX1 KYNU	1.49e-05	190	185	7	ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCell	PND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DRC7 TRAF3IP1 HOATZ DNAH12 IQCA1 DNAH6 HYDIN	1.49e-05	190	185	7	088e3f39a1e5e11354d6e7458e8e6a39f14936b3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 NAPEPLD HKDC1 EVC CAT HUNK SGPL1	1.49e-05	190	185	7	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	NS-moderate-d_16-33-Epithelial-FOXN4+\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEP85 DYNC2H1 ARHGEF11 ECT2 LIG1 DEUP1 HELLS	1.49e-05	190	185	7	250ca4a605c1cccd77d23383e4fe6f91cf3609ba
Disease	Brugada syndrome (implicated_via_orthology)	GSTM1 GSTM3 GSTM5	2.25e-06	5	181	3	DOID:0050451 (implicated_via_orthology)
Disease	Majewski Syndrome	TRAF3IP1 DYNC2H1 IFT172	7.86e-05	14	181	3	C0024507
Disease	keratosis (is_implicated_in)	CAT GSTM1	1.12e-04	3	181	2	DOID:161 (is_implicated_in)
Disease	Colorectal Carcinoma	SF3A1 RPS6KB1 ODC1 PREX2 GSTM1 GSTM3 LIG1 FAT1 ZZZ3 WNT16 VPS13A C2CD6 NCR1 PHIP	1.18e-04	702	181	14	C0009402
Disease	dodecenedioate (C12:1-DC) measurement	HEATR4 CYP4Z2P	2.23e-04	4	181	2	EFO_0800561
Disease	Liver Cirrhosis, Experimental	SYNRG COL12A1 ASPN EXTL1 ECT2 TMEM106A GSTM1 FAT1 MYO1F LTA4H PC KYNU RAC2 HELLS	3.20e-04	774	181	14	C0023893
Disease	autism spectrum disorder (implicated_via_orthology)	CNTNAP3B HTR2C NLGN1 GSTM1 GSTM5 PREX1	3.63e-04	152	181	6	DOID:0060041 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	NT5DC4 GSTM1 CAPN8 GSTM3 GSTM5 SGPL1 HSD17B4	3.81e-04	215	181	7	DOID:9970 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	MTMR4 SGPL1 FGD3	4.18e-04	24	181	3	DOID:10595 (implicated_via_orthology)
Disease	Edema	CAT STAT6 SLC9A2	5.32e-04	26	181	3	C0013604
Disease	Anasarca	CAT STAT6 SLC9A2	5.32e-04	26	181	3	C0151603
Disease	larynx cancer (is_implicated_in)	GSTM1 GSTM3	5.52e-04	6	181	2	DOID:2596 (is_implicated_in)
Disease	VACTERL association (implicated_via_orthology)	DYNC2H1 IFT172	5.52e-04	6	181	2	DOID:14679 (implicated_via_orthology)
Disease	lymphocyte count	SEL1L SYNRG FRAS1 MYO1D HKDC1 BRD3 SAMHD1 VARS2 ARHGEF11 HDAC7 PREX2 CC2D2B CILP2 TAF8 SGPL1 NFKB1 HSD17B4 PREX1 KYNU RAC2	6.97e-04	1464	181	20	EFO_0004587
Disease	10-undecenoate 11:1n1 measurement	CYP4Z1 CYP4Z2P	7.70e-04	7	181	2	EFO_0021099
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	FER1L6 OTOF	7.70e-04	7	181	2	DOID:11724 (implicated_via_orthology)
Disease	Acute lymphocytic leukemia	BLM LIG4	7.70e-04	7	181	2	C0023449
Disease	angle-closure glaucoma (is_implicated_in)	CAT GSTM1	7.70e-04	7	181	2	DOID:13550 (is_implicated_in)
Disease	Polydactyly	FRAS1 TRAF3IP1 DYNC2H1 IFT172 EVC	7.91e-04	117	181	5	C0152427
Disease	adult onset asthma	HDAC7 STAT6 SLC9A2 MUC2 D2HGDH	8.22e-04	118	181	5	EFO_1002011
Disease	X-24748 measurement	HEATR4 CYP4Z2P	1.02e-03	8	181	2	EFO_0022136
Disease	cerebellar ataxia (implicated_via_orthology)	VPS13A PNPLA7	1.02e-03	8	181	2	DOID:0050753 (implicated_via_orthology)
Disease	optic neuritis (is_implicated_in)	CAT GSTM1	1.02e-03	8	181	2	DOID:1210 (is_implicated_in)
Disease	Disproportionate short stature	DYM DYNC2H1 EVC DHCR24	1.31e-03	77	181	4	C0878659
Disease	pyoderma gangrenosum	HSD17B4 USP15	1.31e-03	9	181	2	EFO_0006835
Disease	X-17653 measurement	HEATR4 HELLS	1.31e-03	9	181	2	EFO_0800783
Disease	cholestasis (implicated_via_orthology)	CAT GSTM1	1.31e-03	9	181	2	DOID:13580 (implicated_via_orthology)
Disease	glucagon-like peptide-1 measurement	COL12A1 AGBL1	1.63e-03	10	181	2	EFO_0008465
Disease	osteonecrosis (is_implicated_in)	CAT GSTM1	1.63e-03	10	181	2	DOID:10159 (is_implicated_in)
Disease	response to selective serotonin reuptake inhibitor	MTMR12 AGBL1 PREX1 KYNU	1.65e-03	82	181	4	EFO_0005658
Disease	Degenerative Diseases, Central Nervous System	GSTM1 GSTM5 KYNU	1.76e-03	39	181	3	C0270715
Disease	Neurodegenerative Disorders	GSTM1 GSTM5 KYNU	1.76e-03	39	181	3	C0524851
Disease	Degenerative Diseases, Spinal Cord	GSTM1 GSTM5 KYNU	1.76e-03	39	181	3	C0751733
Disease	Lymphoma	BLM LIG4 RAC2	1.90e-03	40	181	3	C0024299
Disease	Jeune thoracic dystrophy	DYNC2H1 IFT172	1.98e-03	11	181	2	C0265275
Disease	senile cataract (is_implicated_in)	CAT GSTM1	1.98e-03	11	181	2	DOID:9669 (is_implicated_in)
Disease	X-21607 measurement	HEATR4 CYP4Z2P	1.98e-03	11	181	2	EFO_0800819
Disease	response to anticoagulant	CHN2 SOX14 HELLS	2.04e-03	41	181	3	GO_0061476
Disease	respiratory system disease	STAT6 SLC9A2 MUC2 D2HGDH UVRAG	2.05e-03	145	181	5	EFO_0000684
Disease	high grade glioma (is_implicated_in)	GSTM1 GSTM3 LIG4	2.19e-03	42	181	3	DOID:3070 (is_implicated_in)
Disease	Short Rib-Polydactyly Syndrome	DYNC2H1 IFT172	2.79e-03	13	181	2	C0036996
Disease	undecenoylcarnitine (C11:1) measurement	HEATR4 CYP4Z2P	2.79e-03	13	181	2	EFO_0800588
Disease	colitis (implicated_via_orthology)	CAT MUC2	2.79e-03	13	181	2	DOID:0060180 (implicated_via_orthology)
Disease	hypertension (biomarker_via_orthology)	CAT GSTM1 GSTM5 RNPEP KCNMB1 HSD17B4	2.86e-03	227	181	6	DOID:10763 (biomarker_via_orthology)
Disease	hearing impairment	TECTA OTOF DIAPH1 HSD17B4	3.16e-03	98	181	4	C1384666
Disease	Chromosome Breakage	CAT GSTM1	3.24e-03	14	181	2	C0376628
Disease	Chromosome Breaks	CAT GSTM1	3.24e-03	14	181	2	C0333704
Disease	Saldino-Noonan Syndrome	DYNC2H1 IFT172	3.24e-03	14	181	2	C0036069
Disease	rostral middle frontal gyrus volume measurement	AGBL1 DEUP1	3.24e-03	14	181	2	EFO_0010328
Disease	X-17654 measurement	HEATR4 HSD17B4	3.73e-03	15	181	2	EFO_0800784
Disease	mosquito bite reaction itch intensity measurement, mosquito bite reaction size measurement	FRAS1 MEIKIN CHN2 STAT6 PIK3C2G HACE1 IQCM	4.27e-03	328	181	7	EFO_0008377, EFO_0008378
Disease	Malignant mesothelioma	COL12A1 GSTM1 MTMR4 LIMCH1	4.62e-03	109	181	4	C0345967
Disease	leukemia	GSTM1 BLM LIG4	4.71e-03	55	181	3	C0023418
Disease	Diffuse Large B-Cell Lymphoma	RPS6KB1 CAT STAT6	4.71e-03	55	181	3	C0079744
Disease	Antihistamine use measurement	STAT6 D2HGDH	4.79e-03	17	181	2	EFO_0009943
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TJP1 MUC2	4.79e-03	17	181	2	DOID:8677 (biomarker_via_orthology)
Disease	allergic disease	HDAC7 STAT6 NFKB1 DIAPH1 D2HGDH KYNU	5.32e-03	258	181	6	MONDO_0005271
Disease	rheumatoid arthritis (is_implicated_in)	CAST GSTM1 CIITA	5.47e-03	58	181	3	DOID:7148 (is_implicated_in)
Disease	Chronic myeloproliferative disorder	ATR LIG4	5.97e-03	19	181	2	C1292778

Protein segments in the cluster

Peptide	Gene	Start	Entry
PDYVKILLKRQDPKS	CYP4Z2P	96	Q8N1L4
IKLNLPDYHKIIKNP	BRD3	66	Q15059
EYFPELKKKRVDIIP	RNPEP	461	Q9H4A4
KDYPLIPVGKLVLNR	CAT	306	P04040
KELPQYLALTPRKKR	CIITA	731	P33076
LLPVNLKLVPGYKKV	BAZ2B	2086	Q9UIF8
NYKVEKKPPVRQIPR	HTR2C	386	P28335
DALEDKKRNPILKYI	ARHGEF11	526	O15085
EYKDKIPLLQQPKRE	PAM	366	P19021
APKEAPKKLIRYIDN	CUEDC2	236	Q9H467
DLKKPPANLYQIIRK	CAPN8	216	A6NHC0
GLTPKKLYKPEVQLR	DIAPH1	766	O60610
SYLPSIKEPERKIKE	DEUP1	316	Q05D60
EEVLKKYLQKVRHPP	DTX4	391	Q9Y2E6
PLNPLLKTIYRKAVK	CC2D2B	256	Q6DHV5
DIPIPKYFLKEKLEV	IQCA1	116	Q86XH1
LKKIPSGLPELKYLQ	ASPN	301	Q9BXN1
EALDNVLKYLPKKDR	ASTE1	271	Q2TB18
DPLLFKYKVQPTKKE	BAZ1A	186	Q9NRL2
VNYRTLPKILDKLAP	AGBL1	936	Q96MI9
PIHFQEKEIPVKLYK	CCDC83	381	Q8IWF9
EKEIPVKLYKDVRSP	CCDC83	386	Q8IWF9
TEKEKIKKLPEYNPR	RCC2	506	Q9P258
AKYPLPLIEKEKISH	CYB5R2	16	Q6BCY4
KPYLKAKRALSPLLQ	PCDH17	1016	O14917
IEKLKEKKLAPITYP	RAC2	126	P15153
NIVKDLPFEPSKKLY	ECT2	316	Q9H8V3
LPFEPSKKLYVVKQE	ECT2	321	Q9H8V3
QKPKSGKYIPLEIDK	IQCM	56	A0A1B0GVH7
PDKKPKVQLVISYED	PIK3C2G	1326	O75747
RDQEELKGKKVPQYP	KCNMB1	61	Q16558
DPEDPSRKIYKFIQK	LTA4H	181	P09960
VKYPLLLKEILKHTP	NET1	316	Q7Z628
LQKFYKIRLPEREKP	FAT1	1246	Q14517
LIIKPYLRAQKEKEL	DNAJC11	406	Q9NVH1
PPKREVVVYAPLSKK	HELLS	461	Q9NRZ9
YEKLQQSPKPGEKER	TRAF3IP1	551	Q8TDR0
QRPEESEPLEKKGKY	NT5DC1	346	Q5TFE4
KKKPAEDILEEYPLN	FRAS1	3931	Q86XX4
RPKPPERINKVKFYI	NCR1	71	O76036
EKLKPKYLEELPEKL	GSTM5	121	P46439
PILLEDYRKIAVDKK	INTS11	101	Q5TA45
KIPKAPGFEKRLQLY	FN3KRP	266	Q9HA64
KAQTLLKNPLYVEKP	MTMR12	531	Q9C0I1
LKNPLYVEKPKLDKG	MTMR12	536	Q9C0I1
KLKDVPLLPSLDYEK	ARMC9	306	Q7Z3E5
PLLPSLDYEKLKKDL	ARMC9	311	Q7Z3E5
AYLKEKEKAIFPPRI	KIAA1109	4871	Q2LD37
KKYPIAEEKTQLPLD	IL12RB2	676	Q99665
PLEVKLKDNYPSILK	C2CD6	481	Q53TS8
RCPKDRPIYEEDLKK	MUC2	1166	Q02817
RIPSAKKYKDIIRQP	PEA15	101	Q15121
LYRKLKEQKGQLLPE	NEK4	91	P51957
KLPEYPSKEILKDRL	HACE1	881	Q8IYU2
IVTKYKEEARKLLPP	HNRNPUL2	621	Q1KMD3
AKTKDPPRYEEAIKQ	MRTFB	866	Q9ULH7
PKYKDRPQIARVVQK	NIPBL	2716	Q6KC79
TKYPELDKLKVNIEP	DNAH12	671	Q6ZR08
PAPRLAAEKTKKEEY	PHRF1	1546	Q9P1Y6
TIDKILKCKLNLPPY	RPS6KB1	301	P23443
LKAKLAQYEPPQEEK	MYCBP	86	Q99417
KKYSLPKDTPQDIII	MEIKIN	356	A0A087WXM9
KLKPQYLEELPGQLK	GSTM3	126	P21266
YKKVENTVLPKPDLP	F8	1491	P00451
LLKDYLKRLPQDAPD	FGD3	306	Q5JSP0
KKPYKELVDQDIQPA	NLGN1	376	Q8N2Q7
KKLGKLPPQYALELL	OAS1	221	P00973
KPVIPERKYQHLAKV	KIAA1191	56	Q96A73
KRILRFKKEYPALQP	PNPLA7	96	Q6ZV29
YIQAKDLFPPKELVK	MTMR4	11	Q9NYA4
YPILRNKIEFKRPGK	IFT172	1691	Q9UG01
EKPLKKQLDKYALEP	PTPN21	81	Q16825
DPKLQKFLKCLYRPI	GPRC6A	691	Q5T6X5
QAKNLLEKYKRRPPA	POP1	676	Q99575
LPFYKRILNKPVGLK	ITCH	661	Q96J02
LEKYVKKDPRLPILL	NT5DC4	191	Q86YG4
PNDCQPDLKRIKKVY	CHN2	261	P52757
KEVSPLPLNLKRLYK	DYNC2H1	3701	Q8NCM8
EIYFLPDHPELKKIK	ATR	1251	Q13535
IQKDAAKKYDFPIPL	C5orf47	111	Q569G3
KLEPLPVLKVYQDHK	DNAH6	71	Q9C0G6
LIYRLEKKPNSILKP	HYDIN	1056	Q4G0P3
KDPIIKLLYVTPEKI	BLM	756	P54132
VKQPLSIYKPDKRGE	LIG4	431	P49917
EQELAAIKKKAYVPP	COL12A1	621	Q99715
VVALPKDRLKKFPEL	DYM	611	Q7RTS9
APKARVPDLDKRKYL	GABARAPL1	36	Q9H0R8
ARLAANPDPKKLLKY	ELOA	41	Q14241
LFVPYKRRKKENELP	DEAF1	296	O75398
DKKKPVPLLLDQDYV	CCNL2	156	Q96S94
LELYKPLPRAGKLKC	HSD17B4	411	P51659
AAEIRIIPAKKYVKL	DHCR24	226	Q15392
IIPAKKYVKLRFEPV	DHCR24	231	Q15392
KELYRVLPEAKKAPG	CEP85	216	Q6P2H3
EKKKPELLLPVYYRL	HEATR4	281	Q86WZ0
IRKKYPDRVPLIVEK	GABARAPL3	21	Q9BY60
APELLARKKYGPKID	HUNK	231	P57058
YQLPDFSKIAPKVKI	AKNAD1	256	Q5T1N1
VLPKKYTIKPPRDLC	DRC7	241	Q8IY82
IPPKYRELLAKKEGI	CAST	201	P20810
EIKSAPLSPKILVKY	MACC1	526	Q6ZN28
KLPRLITPPEAKKYF	EFHB	281	Q8N7U6
LKERVLIPVKQYPKF	KHDRBS1	156	Q07666
LPEDPKYALKKVDEI	ESCO1	671	Q5FWF5
QPYKVIKQKLEGRPE	HEPACAM2	376	A8MVW5
PGKKEDLYLKPIQRT	EEF2	436	P13639
KAKVIYPINQKFRPL	EVC	116	P57679
VYFGLPPKRKEEKLL	DCLRE1A	561	Q6PJP8
EPNLKLRYKPKKSLE	HDAC7	156	Q8WUI4
GKYPDIISRIPKIKL	LIG1	596	P18858
LPFEKAYEKLQILKP	DUSP12	136	Q9UNI6
KDEYLKKTRDGVLPP	CFAP47	1441	Q6ZTR5
KYCVRPKKPAQEALI	C4orf51	141	C9J302
VKPLLQKRPKPDEKY	ODC1	336	P11926
ALLYTLDKKPLKPIR	CNTNAP3B	191	Q96NU0
LKALLDPKGILNPYK	D2HGDH	501	Q8N465
QTAYVPAPLRKKKAE	LIMCH1	276	Q9UPQ0
PLDISPRKPKKYELR	OTOF	1721	Q9HC10
EKTVKKKRPPLQEYV	UPF2	761	Q9HAU5
KVPEKLGYALRPQEK	IL4I1	161	Q96RQ9
YVELKKANPDLPILI	NDUFA2	41	O43678
KDRDKYIPKQLNPVF	FER1L6	1391	Q2WGJ9
KIDIPLQYPGKFKLL	GAREM2	76	Q75VX8
DYPKSIPLKIFAKDI	ARHGAP20	191	Q9P2F6
LVLYEIPTKPGEKKD	VARS2	81	Q5ST30
DNPYLRPVKKPKIRR	TAF8	291	Q7Z7C8
LVALIPYGDQRLKPK	TMEM106A	76	Q96A25
DKLTEKEREFPLYPK	UVRAG	401	Q9P2Y5
LNEKPALPVIRDKYK	SYNRG	1101	Q9UMZ2
PKLKDAREILKQIEY	SAMHD1	436	Q9Y3Z3
NKDYEEPKKVRKPAL	SEL1L	101	Q9UBV2
PQYPKRLHKVVRKLV	HKDC1	421	Q2TB90
VPLLPSDVKLKLYDR	MOV10	481	Q9HCE1
EKLKPKYLEELPEKL	GSTM1	121	P09488
RISKELISLPYKPKA	HOATZ	131	Q6PI97
KYPLLLKELAKRTPG	PREX1	201	Q8TCU6
KARFAPYKPQDILLK	TANC1	356	Q9C0D5
PEYQKIELPKKLAKR	PGAP1	46	Q75T13
YEKIANILKDKDPPI	PDIA4	101	P13667
RDRKTIPIKYPLKEI	IARS1	836	P41252
LDKTRSKPKIIPYLD	ARHGAP5	246	Q13017
YAKALIEPLKPEERK	STARD9	1116	Q9P2P6
ILYAKLPLPTDKIQK	TDRD7	401	Q8NHU6
QVIVRKDYDPKASKP	SF3A1	386	Q15459
PVLFKDPVSVQRKKY	EXTL1	656	Q92935
PKYFKEALQLRPTRK	TRPT1	211	Q86TN4
DPVPEVAKLAVKYKI	SGPL1	296	O95470
QIERLLNKPGLKYKP	AKR1B15	166	C9JRZ8
LDKLEKPYLVKHPES	CILP2	286	Q8IUL8
PDYAKILLKRQDPKS	CYP4Z1	96	Q86W10
RPEYLEIDINKKKPD	TECTA	746	O75443
KIEPLPKEVKVYLLT	PLA1A	316	Q53H76
LVKQYPPEFRKKPIL	TDP1	211	Q9NUW8
LVQKALKPPPIKLYR	XRCC6	276	P12956
PDDIINCLKKYPKAL	TGFBRAP1	576	Q8WUH2
PELYFQKTKKQDIPR	TRAM1L1	181	Q8N609
YAPPGKEKQRKTEEL	THRAP3	476	Q9Y2W1
VPSSRIKYDPLKEEK	VPS13A	91	Q96RL7
IKPVQRVLKYPLLLK	TIAM2	1246	Q8IVF5
DYLPLKPRVGKAAKE	MTREX	121	P42285
RKPKKLQYAKPEDLE	PHIP	1661	Q8WWQ0
RYLSLPKNTKLPEKL	SLC9A2	666	Q9UBY0
IRDLAQLKNLYPKKP	STAT6	606	P42226
RLKQDYLRIKKDPVP	UBE2J2	16	Q8N2K1
PNVYKRKNKEIKIEP	EZH1	316	Q92800
KKPYIQLKDADGRPD	USP15	401	Q9Y4E8
QKELCKRKPYLLPSI	WNT16	56	Q9UBV4
YPLILKELLKRTPRK	PREX2	176	Q70Z35
LEPTLYRKLQDIKEK	SMCO3	91	A2RU48
SPRYKIIEKKQPVAF	TRBV11-3	26	A0A5A6
PKLKLPKDRQYVVRL	YJU2	21	Q9BW85
EKNVELRKKKPDYLP	SART1	301	O43290
KTLYRIPEPQKPQLK	TJP1	1321	Q07157
PELYFQKTKKEDIPR	TRAM1	181	Q15629
KPPKSLYIEVRCLKD	GINS1	141	Q14691
VVSDKYNLKPIPLKR	PPP1R10	231	Q96QC0
KVLQDLVPDDRKLKY	ZNF512	366	Q96ME7
KKLEQLLIKYPPEEV	ZZZ3	661	Q8IYH5
SPNVRRLEYKPIKKV	PC	26	P11498
RKPKNLLKKDRYVFP	SOX14	81	O95416
FLPERSYTEVLKKKP	TEX36	156	Q5VZQ5
PTPKRYKILLEAKAF	KYNU	151	Q16719
YVRCIKPNDKKSPQI	MYO1D	586	O94832
KPIKRDLILTPKCVY	MYO1F	776	O00160
LKKEVLIPPYELFKV	ART4	241	Q93070
KIPYKLELKNEPGRT	N4BP1	601	O75113
FIRCIKPNEYKKPLL	MYO7B	651	Q6PIF6
KPNEYKKPLLFDREL	MYO7B	656	Q6PIF6
YKGPLDPQRVKIEDK	MYOM3	936	Q5VTT5
SKEELDKELPVLKPY	NAPEPLD	96	Q6IQ20
IISEKKYRQPPDRNK	NEB	2441	P20929
KLQLYKLLEIPDPDK	NFKB1	816	P19838