Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	gated channel activity	CACNA1A GABRG1 CACNA1E TMEM87A CLCA1 KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	1.54e-07	334	103	12	GO:0022836
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1A CACNA1E KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	4.28e-07	182	103	9	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1A CACNA1E KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	4.69e-07	184	103	9	GO:0022832
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1A GABRG1 CACNA1E SCN11A TMEM87A CLCA1 KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	6.90e-07	459	103	13	GO:0005216
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1A CACNA1E KCNA7 KCNC2 KCNC3 KCNC4 KCNK3 CACNA1H	1.21e-06	152	103	8	GO:0022843
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1A CACNA1E SCN11A TMEM87A KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	1.60e-06	343	103	11	GO:0005261
GeneOntologyMolecularFunction	channel activity	CACNA1A GABRG1 CACNA1E SCN11A TMEM87A CLCA1 KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	3.06e-06	525	103	13	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1A GABRG1 CACNA1E SCN11A TMEM87A CLCA1 KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	3.12e-06	526	103	13	GO:0022803
GeneOntologyMolecularFunction	delayed rectifier potassium channel activity	KCNA7 KCNC2 KCNC3 KCNC4	1.24e-05	28	103	4	GO:0005251
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1A CACNA1E SCN11A TMEM87A KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	2.82e-05	465	103	11	GO:0046873
GeneOntologyMolecularFunction	microfilament motor activity	MYO5A MYO10 MYO19 MYO15A	4.31e-05	38	103	4	GO:0000146
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1A CACNA1E CACNA1H	4.66e-05	14	103	3	GO:0008331
GeneOntologyMolecularFunction	potassium channel activity	TMEM87A KCNA7 KCNC2 KCNC3 KCNC4 KCNK3	5.31e-05	128	103	6	GO:0005267
GeneOntologyMolecularFunction	plus-end directed microfilament motor activity	MYO10 MYO19	7.88e-05	3	103	2	GO:0060002
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	KCNC2 KCNC4 SCN1A	8.60e-05	17	103	3	GO:0099508
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA1A GABRG1 CACNA1E SCN11A TMEM87A CLCA1 KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	1.41e-04	758	103	13	GO:0015318
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	KCNA7 KCNC2 KCNC3 KCNC4 KCNK3	1.86e-04	102	103	5	GO:0005249
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1A GABRG1 CACNA1E SCN11A TMEM87A CLCA1 KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	2.19e-04	793	103	13	GO:0015075
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	TMEM87A KCNA7 KCNC2 KCNC3 KCNC4 KCNK3	2.29e-04	167	103	6	GO:0015079
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN11A SCN1A CACNA1H	3.18e-04	26	103	3	GO:0005248
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYO5A MYO10 MYO19 KIF15 MYO15A	3.65e-04	118	103	5	GO:0003774
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNA1A CACNA1E SCN11A TMEM87A KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	3.91e-04	627	103	11	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNA1A CACNA1E SCN11A TMEM87A KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	6.30e-04	664	103	11	GO:0008324
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1A CACNA1E	9.26e-04	9	103	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1A CACNA1E	9.26e-04	9	103	2	GO:0099626
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1A CACNA1E CACNA1H	1.72e-03	46	103	3	GO:0005245
GeneOntologyMolecularFunction	RNA polymerase III general transcription initiation factor activity	GTF3C1 SNAPC4	1.98e-03	13	103	2	GO:0000995
GeneOntologyMolecularFunction	sodium channel activity	SCN11A SCN1A CACNA1H	2.45e-03	52	103	3	GO:0005272
GeneOntologyMolecularFunction	MAP kinase activity	MAPK14 MAPK12	3.02e-03	16	103	2	GO:0004707
GeneOntologyMolecularFunction	ATP-dependent activity	MYO5A MYO10 MYO19 DHX57 NLRP3 KIF15 MYO15A YME1L1 HELLS	4.48e-03	614	103	9	GO:0140657
GeneOntologyMolecularFunction	GABA receptor binding	GABRG1 GABARAP	4.71e-03	20	103	2	GO:0050811
GeneOntologyMolecularFunction	general transcription initiation factor activity	GTF3C1 TAF5 SNAPC4	5.24e-03	68	103	3	GO:0140223
GeneOntologyMolecularFunction	SNARE binding	CACNA1A MYO5A SEPTIN8 SYT15	5.41e-03	136	103	4	GO:0000149
GeneOntologyBiologicalProcess	transmission of nerve impulse	CACNA1A CACNA1E SCN11A KCNC4 SCN1A CACNA1H	1.87e-05	112	101	6	GO:0019226
GeneOntologyCellularComponent	cation channel complex	CACNA1A CACNA1E SCN11A KCNA7 KCNC2 KCNC3 KCNC4 SCN1A CACNA1H	2.27e-06	235	102	9	GO:0034703
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNA1A GABRG1 CACNA1E SCN11A PORCN KCNA7 KCNC2 KCNC3 KCNC4 SCN1A CACNA1H	2.39e-06	378	102	11	GO:0034702
GeneOntologyCellularComponent	presynaptic membrane	CACNA1A CACNA1E SCN11A ADORA3 KCNC2 KCNC3 KCNC4 SCN1A CACNA1H	8.64e-06	277	102	9	GO:0042734
GeneOntologyCellularComponent	synaptic membrane	CACNA1A GABRG1 CACNA1E SCN11A CLSTN3 LRRC4 ADORA3 KCNC2 KCNC3 KCNC4 SCN1A CACNA1H	2.72e-05	583	102	12	GO:0097060
GeneOntologyCellularComponent	glutamatergic synapse	CACNA1A SCN11A CLSTN3 MYO5A SPTAN1 PORCN LRRC4 JAK2 MAPK14 KCNC3 KCNC4 NGEF HRAS CACNA1H	4.25e-05	817	102	14	GO:0098978
GeneOntologyCellularComponent	transmembrane transporter complex	CACNA1A GABRG1 CACNA1E SCN11A PORCN KCNA7 KCNC2 KCNC3 KCNC4 SCN1A CACNA1H	4.95e-05	523	102	11	GO:1902495
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN11A SCN1A CACNA1H	7.30e-05	17	102	3	GO:0001518
GeneOntologyCellularComponent	transporter complex	CACNA1A GABRG1 CACNA1E SCN11A PORCN KCNA7 KCNC2 KCNC3 KCNC4 SCN1A CACNA1H	7.76e-05	550	102	11	GO:1990351
GeneOntologyCellularComponent	dendrite membrane	GABRG1 KCNC2 KCNC3 KCNC4	1.61e-04	56	102	4	GO:0032590
GeneOntologyCellularComponent	postsynaptic membrane	CACNA1A GABRG1 CACNA1E CLSTN3 LRRC4 KCNC2 KCNC3 KCNC4 CACNA1H	1.65e-04	405	102	9	GO:0045211
GeneOntologyCellularComponent	myosin complex	MYO5A MYO10 MYO19 MYO15A	1.98e-04	59	102	4	GO:0016459
GeneOntologyCellularComponent	sodium channel complex	SCN11A SCN1A CACNA1H	3.76e-04	29	102	3	GO:0034706
GeneOntologyCellularComponent	postsynapse	CACNA1A GABRG1 CACNA1E CLSTN3 MYO5A SPTAN1 RPS13 LRRC4 JAK2 KCNC2 KCNC3 KCNC4 NGEF CACNA1H	4.21e-04	1018	102	14	GO:0098794
GeneOntologyCellularComponent	cell body	CACNA1A CACNA1E SCN11A MYO5A MYO10 GABARAP KCNC2 KCNC3 KCNC4 TMEM132E SCN1A BRINP2 CACNA1H	5.83e-04	929	102	13	GO:0044297
GeneOntologyCellularComponent	neuron projection membrane	GABRG1 KCNC2 KCNC3 KCNC4	6.98e-04	82	102	4	GO:0032589
GeneOntologyCellularComponent	somatodendritic compartment	CACNA1A GABRG1 CACNA1E SCN11A CLSTN3 MYO5A MYO10 LRRC4 ADORA3 KCNC2 KCNC3 KCNC4 SCN1A BRINP2 CACNA1H	8.88e-04	1228	102	15	GO:0036477
GeneOntologyCellularComponent	main axon	SPTAN1 KCNC2 KCNC3 SCN1A	9.49e-04	89	102	4	GO:0044304
GeneOntologyCellularComponent	voltage-gated potassium channel complex	KCNA7 KCNC2 KCNC3 KCNC4	1.03e-03	91	102	4	GO:0008076
GeneOntologyCellularComponent	neuronal cell body membrane	KCNC2 KCNC3 KCNC4	1.21e-03	43	102	3	GO:0032809
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1A CACNA1E CACNA1H	1.47e-03	46	102	3	GO:0005891
GeneOntologyCellularComponent	plasma membrane protein complex	CACNA1A CACNA1E SCN11A PORCN JAK2 KCNA7 KCNC2 KCNC3 KCNC4 SCN1A CACNA1H	1.56e-03	785	102	11	GO:0098797
GeneOntologyCellularComponent	cell body membrane	KCNC2 KCNC3 KCNC4	1.56e-03	47	102	3	GO:0044298
GeneOntologyCellularComponent	potassium channel complex	KCNA7 KCNC2 KCNC3 KCNC4	1.69e-03	104	102	4	GO:0034705
GeneOntologyCellularComponent	actin cytoskeleton	KNTC1 MYO5A MYO10 MYO19 SPTAN1 GABARAP TAF5 MYO15A TNS3	2.03e-03	576	102	9	GO:0015629
GeneOntologyCellularComponent	neuronal cell body	CACNA1A CACNA1E SCN11A MYO5A MYO10 KCNC2 KCNC3 KCNC4 SCN1A BRINP2 CACNA1H	2.52e-03	835	102	11	GO:0043025
GeneOntologyCellularComponent	CHD-type complex	MTA1 MTA3	3.06e-03	17	102	2	GO:0090545
GeneOntologyCellularComponent	NuRD complex	MTA1 MTA3	3.06e-03	17	102	2	GO:0016581
GeneOntologyCellularComponent	dendrite	CACNA1A GABRG1 CLSTN3 MYO5A LRRC4 ADORA3 KCNC2 KCNC3 KCNC4 BRINP2 CACNA1H	3.10e-03	858	102	11	GO:0030425
GeneOntologyCellularComponent	dendritic tree	CACNA1A GABRG1 CLSTN3 MYO5A LRRC4 ADORA3 KCNC2 KCNC3 KCNC4 BRINP2 CACNA1H	3.16e-03	860	102	11	GO:0097447
GeneOntologyCellularComponent	transcription factor TFTC complex	USP22 TAF5	3.43e-03	18	102	2	GO:0033276
GeneOntologyCellularComponent	presynapse	CACNA1A CACNA1E SCN11A MYO5A SEPTIN8 ADORA3 KCNC2 KCNC3 KCNC4 SCN1A CACNA1H	3.96e-03	886	102	11	GO:0098793
GeneOntologyCellularComponent	filopodium tip	MYO5A MYO10	4.23e-03	20	102	2	GO:0032433
GeneOntologyCellularComponent	axolemma	KCNC2 KCNC3	4.66e-03	21	102	2	GO:0030673
GeneOntologyCellularComponent	perikaryon	CACNA1A CACNA1E KCNC2 KCNC3 CACNA1H	4.76e-03	223	102	5	GO:0043204
MousePheno	abnormal channel response	CACNA1A CACNA1E SCN11A CACNA1H	2.78e-05	33	75	4	MP:0003484
MousePheno	clonic seizures	CACNA1A MYO5A SCN1A	5.17e-05	14	75	3	MP:0003996
Domain	Channel_four-helix_dom	CACNA1A CACNA1E SCN11A KCNA7 KCNC2 KCNC3 KCNC4 SCN1A CACNA1H	1.51e-11	57	98	9	IPR027359
Domain	-	CACNA1A CACNA1E SCN11A KCNA7 KCNC2 KCNC3 KCNC4 SCN1A CACNA1H	1.51e-11	57	98	9	1.20.120.350
Domain	Ion_trans_dom	CACNA1A CACNA1E SCN11A KCNA7 KCNC2 KCNC3 KCNC4 SCN1A CACNA1H	8.54e-09	114	98	9	IPR005821
Domain	Ion_trans	CACNA1A CACNA1E SCN11A KCNA7 KCNC2 KCNC3 KCNC4 SCN1A CACNA1H	8.54e-09	114	98	9	PF00520
Domain	K_chnl_volt-dep_Kv3	KCNC2 KCNC3 KCNC4	5.58e-07	4	98	3	IPR003974
Domain	K_chnl_volt-dep_Kv	KCNA7 KCNC2 KCNC3 KCNC4	1.14e-05	27	98	4	IPR003968
Domain	VDCCAlpha1	CACNA1A CACNA1E CACNA1H	1.64e-05	10	98	3	IPR002077
Domain	VG_K_chnl	KCNA7 KCNC2 KCNC3 KCNC4	2.59e-05	33	98	4	IPR028325
Domain	Potassium_chann	KCNC3 KCNC4	2.73e-05	2	98	2	PF11404
Domain	K_chnl_volt-dep_Kv3_ID	KCNC3 KCNC4	2.73e-05	2	98	2	IPR021105
Domain	Myosin_head_motor_dom	MYO5A MYO10 MYO19 MYO15A	4.59e-05	38	98	4	IPR001609
Domain	MYOSIN_MOTOR	MYO5A MYO10 MYO19 MYO15A	4.59e-05	38	98	4	PS51456
Domain	Myosin_head	MYO5A MYO10 MYO19 MYO15A	4.59e-05	38	98	4	PF00063
Domain	MYSc	MYO5A MYO10 MYO19 MYO15A	4.59e-05	38	98	4	SM00242
Domain	Dynamin_GTPase	NUGGC EHD2 MX2	6.09e-05	15	98	3	IPR001401
Domain	Dynamin_N	NUGGC EHD2 MX2	6.09e-05	15	98	3	PF00350
Domain	Dynamin_SF	NUGGC EHD2 MX2	6.09e-05	15	98	3	IPR022812
Domain	IQ	MYO5A MYO10 MYO19 SCN1A MYO15A	6.71e-05	81	98	5	SM00015
Domain	IQ_motif_EF-hand-BS	MYO5A MYO10 MYO19 SCN1A MYO15A	1.11e-04	90	98	5	IPR000048
Domain	IQ	MYO5A MYO10 MYO19 SCN1A MYO15A	1.29e-04	93	98	5	PS50096
Domain	P-loop_NTPase	NUGGC MYO5A MYO10 MYO19 DHX57 NLRP3 EHD2 SEPTIN8 KIF15 HRAS MYO15A YME1L1 MX2 HELLS	1.33e-04	848	98	14	IPR027417
Domain	MAPK_p38	MAPK14 MAPK12	1.62e-04	4	98	2	IPR008352
Domain	GPR107-like	TMEM87A TMEM87B	1.62e-04	4	98	2	IPR009637
Domain	Lung_7-TM_R	TMEM87A TMEM87B	1.62e-04	4	98	2	PF06814
Domain	BTB_2	KCNA7 KCNC2 KCNC3 KCNC4	1.71e-04	53	98	4	PF02214
Domain	T1-type_BTB	KCNA7 KCNC2 KCNC3 KCNC4	1.71e-04	53	98	4	IPR003131
Domain	IQ	MYO5A MYO10 SCN1A MYO15A	5.29e-04	71	98	4	PF00612
Domain	VDCC_a1su_IQ	CACNA1A CACNA1E	5.63e-04	7	98	2	IPR014873
Domain	GPHH	CACNA1A CACNA1E	5.63e-04	7	98	2	PF16905
Domain	GPHH_dom	CACNA1A CACNA1E	5.63e-04	7	98	2	IPR031649
Domain	Ca_chan_IQ	CACNA1A CACNA1E	5.63e-04	7	98	2	SM01062
Domain	Ca_chan_IQ	CACNA1A CACNA1E	5.63e-04	7	98	2	PF08763
Domain	Myb_DNA-binding	MTA1 MTA3 SNAPC4	8.12e-04	35	98	3	PF00249
Domain	MYTH4	MYO10 MYO15A	9.58e-04	9	98	2	PS51016
Domain	MyTH4_dom	MYO10 MYO15A	9.58e-04	9	98	2	IPR000857
Domain	MyTH4	MYO10 MYO15A	9.58e-04	9	98	2	PF00784
Domain	MyTH4	MYO10 MYO15A	9.58e-04	9	98	2	SM00139
Domain	MYB_LIKE	MTA1 MTA3 SNAPC4	1.03e-03	38	98	3	PS50090
Domain	Na_channel_asu	SCN11A SCN1A	1.19e-03	10	98	2	IPR001696
Domain	Na_trans_assoc	SCN11A SCN1A	1.19e-03	10	98	2	IPR010526
Domain	Na_trans_assoc	SCN11A SCN1A	1.19e-03	10	98	2	PF06512
Domain	BAH	MTA1 MTA3	1.45e-03	11	98	2	SM00439
Domain	BAH	MTA1 MTA3	1.45e-03	11	98	2	PF01426
Domain	BAH	MTA1 MTA3	1.45e-03	11	98	2	PS51038
Domain	BAH_dom	MTA1 MTA3	1.45e-03	11	98	2	IPR001025
Domain	MAP_kinase_CS	MAPK14 MAPK12	1.74e-03	12	98	2	IPR003527
Domain	ZnF_GATA	MTA1 MTA3	1.74e-03	12	98	2	SM00401
Domain	MAPK	MAPK14 MAPK12	1.74e-03	12	98	2	PS01351
Domain	ELM2	MTA1 MTA3	2.05e-03	13	98	2	PF01448
Domain	ELM2	MTA1 MTA3	2.05e-03	13	98	2	PS51156
Domain	ELM2_dom	MTA1 MTA3	2.05e-03	13	98	2	IPR000949
Domain	ELM2	MTA1 MTA3	2.05e-03	13	98	2	SM01189
Domain	FERM_central	MYO10 JAK2 MYO15A	2.17e-03	49	98	3	IPR019748
Domain	FERM_domain	MYO10 JAK2 MYO15A	2.17e-03	49	98	3	IPR000299
Domain	FERM_1	MYO10 JAK2 MYO15A	2.30e-03	50	98	3	PS00660
Domain	FERM_2	MYO10 JAK2 MYO15A	2.30e-03	50	98	3	PS00661
Domain	SANT	MTA1 MTA3 SNAPC4	2.30e-03	50	98	3	SM00717
Domain	FERM_3	MYO10 JAK2 MYO15A	2.30e-03	50	98	3	PS50057
Domain	Band_41_domain	MYO10 JAK2 MYO15A	2.30e-03	50	98	3	IPR019749
Domain	B41	MYO10 JAK2 MYO15A	2.30e-03	50	98	3	SM00295
Domain	G_DYNAMIN_dom	EHD2 MX2	2.38e-03	14	98	2	IPR030381
Domain	G_DYNAMIN_2	EHD2 MX2	2.38e-03	14	98	2	PS51718
Domain	SANT/Myb	MTA1 MTA3 SNAPC4	2.57e-03	52	98	3	IPR001005
Domain	BTB	KLHL28 KCNA7 KCNC2 KCNC3 KCNC4	2.59e-03	180	98	5	SM00225
Domain	Znf_GATA	MTA1 MTA3	2.74e-03	15	98	2	IPR000679
Domain	GATA	MTA1 MTA3	2.74e-03	15	98	2	PF00320
Domain	NTF2-like_dom	C3orf38 NXF1	2.74e-03	15	98	2	IPR032710
Domain	BTB/POZ_dom	KLHL28 KCNA7 KCNC2 KCNC3 KCNC4	2.92e-03	185	98	5	IPR000210
Domain	GATA_ZN_FINGER_1	MTA1 MTA3	3.12e-03	16	98	2	PS00344
Domain	GATA_ZN_FINGER_2	MTA1 MTA3	3.12e-03	16	98	2	PS50114
Domain	SKP1/BTB/POZ	KLHL28 KCNA7 KCNC2 KCNC3 KCNC4	3.20e-03	189	98	5	IPR011333
Pathway	REACTOME_P38MAPK_EVENTS	MAPK14 MAPK12 HRAS	4.31e-05	13	77	3	M1441
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCNA7 KCNC2 KCNC3 KCNC4	7.15e-05	41	77	4	MM14546
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCNA7 KCNC2 KCNC3 KCNC4	8.64e-05	43	77	4	M1056
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1A CACNA1E SCN11A CLCA1 KCNA7 KCNC2 KCNC3 KCNC4 SCN1A KCNK3 CACNA1H	5.03e-13	139	105	11	16985003
Pubmed	Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1.	KCNC2 KCNC3 KCNC4	2.67e-08	3	105	3	1740329
Pubmed	Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.	CACNA1A KNTC1 MYO5A MYO10 C3orf38 MC1R	8.71e-08	72	105	6	25917818
Pubmed	Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.	KCNC2 KCNC3 KCNC4	1.07e-07	4	105	3	21912965
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1A CACNA1E CACNA1H	2.22e-06	9	105	3	16382099
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	ZNF148 RPS13 DHX57 TRIP12 GTF3C1 MTA3 BOP1 TAF5 PLCH1 HELLS	5.16e-06	533	105	10	30554943
Pubmed	Ras effectors and their role in mitogenesis and oncogenesis.	MAPK14 MAPK12 HRAS	5.77e-06	12	105	3	9297626
Pubmed	Human transcription factor protein interaction networks.	SIN3B ZNF148 USP22 MYO5A SPTAN1 MC1R RPS13 TRIM24 STAT2 MTA1 GTF3C1 MTA3 NUP93 TAF5 NXF1 HELLS	6.04e-06	1429	105	16	35140242
Pubmed	International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.	KCNA7 KCNC2 KCNC3 KCNC4	6.59e-06	40	105	4	16382104
Pubmed	Kv3 voltage-gated potassium channels regulate neurotransmitter release from mouse motor nerve terminals.	KCNC3 KCNC4	9.03e-06	2	105	2	15610163
Pubmed	Gender specific hippocampal whole genome transcriptome data from mice lacking the Cav2.3 R-type or Cav3.2 T-type voltage-gated calcium channel.	CACNA1E CACNA1H	9.03e-06	2	105	2	28393090
Pubmed	p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms.	MAPK14 MAPK12	9.03e-06	2	105	2	19251701
Pubmed	Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport.	TMEM87A TMEM87B	9.03e-06	2	105	2	26157166
Pubmed	Active mutants of the human p38alpha mitogen-activated protein kinase.	MAPK14 MAPK12	9.03e-06	2	105	2	15284239
Pubmed	The metastasis-associated genes MTA1 and MTA3 are abundantly expressed in human placenta and chorionic carcinoma cells.	MTA1 MTA3	9.03e-06	2	105	2	19363681
Pubmed	Non-Mendelian inheritance during inbreeding of Cav3.2 and Cav2.3 deficient mice.	CACNA1E CACNA1H	9.03e-06	2	105	2	33009476
Pubmed	CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute respiratory distress syndrome.	MAPK14 CLCA1	9.03e-06	2	105	2	38597420
Pubmed	Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.	CACNA1A CACNA1E	9.03e-06	2	105	2	16381801
Pubmed	Two separate Ni(2+) -sensitive voltage-gated Ca(2+) channels modulate transretinal signalling in the isolated murine retina.	CACNA1E CACNA1H	9.03e-06	2	105	2	21883984
Pubmed	p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.	MAPK14 MAPK12	9.03e-06	2	105	2	17724032
Pubmed	E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/caspase-1/IL-1β-mediated pyroptosis in endometriosis.	TRIM24 NLRP3	9.03e-06	2	105	2	33724611
Pubmed	Function and regulation of MTA1 and MTA3 in malignancies of the female reproductive system.	MTA1 MTA3	9.03e-06	2	105	2	25319202
Pubmed	SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases.	MAPK14 MAPK12	9.03e-06	2	105	2	8925912
Pubmed	Meteorin-like protein elevation post-exercise improved vascular inflammation among coronary artery disease patients by downregulating NLRP3 inflammasome activity.	METRNL NLRP3	9.03e-06	2	105	2	38054817
Pubmed	Inherited neuronal ion channelopathies: new windows on complex neurological diseases.	CACNA1A SCN1A	9.03e-06	2	105	2	19005038
Pubmed	The p38 SAPK pathway is required for Ha-ras induced in vitro invasion of NIH3T3 cells.	MAPK14 HRAS	9.03e-06	2	105	2	15652346
Pubmed	Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission.	GABRG1 GABARAP	9.03e-06	2	105	2	33436612
Pubmed	Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like.	METRNL NLRP3	9.03e-06	2	105	2	34943988
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	SIN3B ZNF148 USP22 TRIM24 MTA1 GTF3C1 NXF1 HELLS	9.21e-06	339	105	8	30415952
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	SPTAN1 RPS13 DHX57 TRIP12 GTF3C1 NUP93 NXF1	1.14e-05	250	105	7	33536335
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SIN3B ZNF148 TRIM24 TRIP12 MTA1 GTF3C1 MTA3 BOP1 SNAPC4 HELLS	1.61e-05	608	105	10	36089195
Pubmed	Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.	SIN3B MTA1 MTA3	2.11e-05	18	105	3	10444591
Pubmed	p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.	NLRP3 MAPK14	2.70e-05	3	105	2	34930303
Pubmed	FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE-/- mice atherosclerosis.	STAT2 JAK2	2.70e-05	3	105	2	34725437
Pubmed	Systematic analysis of three FHM genes in 39 sporadic patients with hemiplegic migraine.	CACNA1A SCN1A	2.70e-05	3	105	2	18056581
Pubmed	Association study between polymorphisms in the CACNA1A, CACNA1C, and CACNA1H genes and drug-resistant epilepsy in the Chinese Han population.	CACNA1A CACNA1H	2.70e-05	3	105	2	26216687
Pubmed	TGF-β1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38β to proapoptotic p38α.	MAPK14 MAPK12	2.70e-05	3	105	2	22522454
Pubmed	C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting.	MAPK14 FBXO32	2.70e-05	3	105	2	21847090
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1A CACNA1E	2.70e-05	3	105	2	38996073
Pubmed	Familial Hemiplegic Migraine	CACNA1A SCN1A	2.70e-05	3	105	2	20301562
Pubmed	Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome.	JAK2 HRAS	2.70e-05	3	105	2	16598312
Pubmed	Identification and characterization of metastasis-associated gene/protein 1 (MTA1).	MTA1 MTA3	2.70e-05	3	105	2	25315816
Pubmed	Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury.	NLRP3 MAPK14	2.70e-05	3	105	2	30152849
Pubmed	The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families.	CACNA1A SCN1A	2.70e-05	3	105	2	29486580
Pubmed	ASK1/p38‑mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy.	NLRP3 MAPK14	2.70e-05	3	105	2	33416127
Pubmed	Structure, expression and functions of MTA genes.	MTA1 MTA3	2.70e-05	3	105	2	26869315
Pubmed	Association of single nucleotide polymorphisms in CACNA 1A/CACNA 1C/CACNA 1H calcium channel genes with diabetic peripheral neuropathy in Chinese population.	CACNA1A CACNA1H	2.70e-05	3	105	2	29581247
Pubmed	p38 MAPK Activity Is Required to Prevent Hyperactivation of NLRP3 Inflammasome.	NLRP3 MAPK14	2.70e-05	3	105	2	34193605
Pubmed	Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons.	KCNC2 KCNC3	2.70e-05	3	105	2	22673617
Pubmed	Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.	STAT2 JAK2	2.70e-05	3	105	2	7746328
Pubmed	Abnormal expression of tyrosine hydroxylase immunoreactivity in cerebellar cortex of ataxic mutant mice.	CACNA1A MYO5A	2.70e-05	3	105	2	10350535
Pubmed	Higher burden of rare frameshift indels in genes related to synaptic transmission separate familial hemiplegic migraine from common types of migraine.	CACNA1A SCN1A	2.70e-05	3	105	2	31980564
Pubmed	Involvement of the p38 mitogen-activated protein kinase alpha, beta, and gamma isoforms in myogenic differentiation.	MAPK14 MAPK12	2.70e-05	3	105	2	18256287
Pubmed	TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle.	MAPK14 FBXO32	2.70e-05	3	105	2	15746179
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1A CACNA1E	2.70e-05	3	105	2	24523520
Pubmed	Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription.	MAPK14 MAPK12	2.70e-05	3	105	2	17088247
Pubmed	Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I.	MAPK14 MAPK12	2.70e-05	3	105	2	18559936
Pubmed	JAK2/STAT2/STAT3 are required for myogenic differentiation.	STAT2 JAK2	2.70e-05	3	105	2	18835816
Pubmed	FHM3 in familial hemiplegic migraine is more resistant to mutation than FHM1 and FHM2.	CACNA1A SCN1A	2.70e-05	3	105	2	19007941
Pubmed	Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.	CACNA1A CACNA1H	5.40e-05	4	105	2	31800012
Pubmed	Essential role for p38alpha MAPK but not p38gamma MAPK in Igf2 expression and myoblast differentiation.	MAPK14 MAPK12	5.40e-05	4	105	2	20610565
Pubmed	Role for mitogen-activated protein kinase p38 alpha in lung epithelial branching morphogenesis.	MAPK14 MAPK12	5.40e-05	4	105	2	18177852
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1A CACNA1E	5.40e-05	4	105	2	37141091
Pubmed	p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice.	MAPK14 MAPK12	5.40e-05	4	105	2	19936205
Pubmed	Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines.	MAPK14 MAPK12	5.40e-05	4	105	2	10066767
Pubmed	Genetic studies of Polish migraine patients: screening for causative mutations in four migraine-associated genes.	CACNA1A SCN1A	5.40e-05	4	105	2	26747084
Pubmed	Localization of Shaw-related K+ channel genes on mouse and human chromosomes.	KCNC2 KCNC3	5.40e-05	4	105	2	8111118
Pubmed	Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.	CACNA1A CACNA1E	5.40e-05	4	105	2	32616470
Pubmed	Vertebrate unconventional myosins.	MYO5A MYO10	5.40e-05	4	105	2	8690736
Pubmed	The SH3 domain of alphaII spectrin is a target for the Fanconi anemia protein, FANCG.	SPTAN1 FANCG	5.40e-05	4	105	2	19102630
Pubmed	Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.	CACNA1A CACNA1H	5.40e-05	4	105	2	21788606
Pubmed	LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia.	CACNA1E CACNA1H	5.40e-05	4	105	2	24381275
Pubmed	Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors.	GABRG1 GABARAP	5.40e-05	4	105	2	11948245
Pubmed	Innate immune responses to rotavirus infection in macrophages depend on MAVS but involve neither the NLRP3 inflammasome nor JNK and p38 signaling pathways.	NLRP3 MAPK14	5.40e-05	4	105	2	26079065
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTAN1 JAK2 HRAS	5.86e-05	25	105	3	8493579
Pubmed	Nerve growth factor signaling, neuroprotection, and neural repair.	MAPK14 MAPK12 HRAS	6.61e-05	26	105	3	11520933
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MYO5A SPTAN1 DHX57 TRIP12 SEPTIN8 MTA1 BOP1 NXF1 TNS3 HELLS	7.01e-05	724	105	10	36232890
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	CACNA1A CACNA1E ZNF148 RGL3 SEPTIN8 TNS3	7.85e-05	233	105	6	37704626
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SIN3B USP22 MYO19 RPS13 TRIP12 JAK2 GTF3C1 ZNF408 ITPRIPL1 NXF1	8.03e-05	736	105	10	29676528
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	SIN3B TRIM24 MTA1 MTA3	8.08e-05	75	105	4	25593309
Pubmed	Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.	CACNA1A CACNA1E	8.97e-05	5	105	2	8825650
Pubmed	Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin.	MAPK14 HRAS	8.97e-05	5	105	2	22982107
Pubmed	Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility.	MTA1 MTA3	8.97e-05	5	105	2	16502042
Pubmed	Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links.	SPTAN1 FANCG	8.97e-05	5	105	2	11401546
Pubmed	Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly.	MAPK14 MAPK12	8.97e-05	5	105	2	15632108
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1A CACNA1E	8.97e-05	5	105	2	11296258
Pubmed	A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras.	RGL3 HRAS	8.97e-05	5	105	2	10869344
Pubmed	Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A.	TMEM87A TMEM87B	8.97e-05	5	105	2	36373655
Pubmed	MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation.	MAPK14 MAPK12	8.97e-05	5	105	2	35971771
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1A CACNA1E	8.97e-05	5	105	2	15451373
Pubmed	CXCL16 upregulates RANKL expression in rheumatoid arthritis synovial fibroblasts through the JAK2/STAT3 and p38/MAPK signaling pathway.	JAK2 MAPK14	8.97e-05	5	105	2	26621504
Pubmed	Brain dopamine receptor plasticity: testing a diathesis-stress hypothesis in an animal model.	KCNC2 KCNC3	8.97e-05	5	105	2	9266612
Pubmed	The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment.	MTA1 MTA3	8.97e-05	5	105	2	31036553
Pubmed	Developmental expression patterns of alpha1H T-type Ca2+ channels during spermatogenesis and organogenesis in mice.	CACNA1E CACNA1H	8.97e-05	5	105	2	12060068
Pubmed	Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation.	MAPK14 MAPK12	8.97e-05	5	105	2	17304211
Pubmed	Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3.	MTA1 MTA3	8.97e-05	5	105	2	11483358
Pubmed	H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells.	MAPK14 HRAS	8.97e-05	5	105	2	15677464
Pubmed	Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1.	MAPK14 HRAS	8.97e-05	5	105	2	11744690
Pubmed	Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.	KCNA7 KCNC2 KCNC4	1.13e-04	31	105	3	8034307
Pubmed	Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice.	MAPK14 MAPK12	1.34e-04	6	105	2	27856911
GeneFamily	Potassium voltage-gated channels	KCNA7 KCNC2 KCNC3 KCNC4	2.35e-05	40	76	4	274
GeneFamily	Calcium voltage-gated channel subunits	CACNA1A CACNA1E CACNA1H	1.73e-04	26	76	3	253
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN11A SCN1A	6.16e-04	9	76	2	1203
GeneFamily	PHD finger proteins\|NuRD complex	MTA1 MTA3	1.12e-03	12	76	2	1305
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO10 JAK2 MYO15A	1.21e-03	50	76	3	1293
GeneFamily	Mitogen-activated protein kinases	MAPK14 MAPK12	1.32e-03	13	76	2	651
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MTA1 MTA3 SNAPC4	1.44e-03	53	76	3	532
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MTA1 MTA3	1.77e-03	15	76	2	82
Coexpression	GSE11961_FOLLICULAR_BCELL_VS_GERMINAL_CENTER_BCELL_DAY7_DN	GABRG1 SIN3B SCN11A RGL3 POPDC2 FBXO6 KCNC3 MX2	9.44e-07	200	99	8	M9341
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A OGFRL1 CLSTN3 MYO5A KCNC3 KCNC4 SCN1A	3.00e-07	188	104	7	1efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A OGFRL1 CLSTN3 MYO5A KCNC3 KCNC4 SCN1A	3.11e-07	189	104	7	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A OGFRL1 CLSTN3 MYO5A KCNC3 KCNC4 SCN1A	3.58e-07	193	104	7	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A OGFRL1 CLSTN3 MAPK12 KCNC3 KCNC4	4.99e-06	186	104	6	d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A CACNA1E CLSTN3 KCNC2 SCN1A BRINP2	6.17e-06	193	104	6	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A CACNA1E CLSTN3 KCNC2 SCN1A BRINP2	6.17e-06	193	104	6	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A CACNA1E CLSTN3 KCNC2 SCN1A BRINP2	6.17e-06	193	104	6	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	OGFRL1 MC1R TMEM87A SCN1A TCEANC2	1.76e-05	137	104	5	ed81624b9167255ce88dcf6ad7f1636376ea0525
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_stem_cell-Mesenchymal_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	OGFRL1 MC1R TMEM87A SCN1A TCEANC2	1.76e-05	137	104	5	47859aa25f32367461c1ec75ed9060bee430c6b7
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gabrg1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GABRG1 KCNC2 KCNK3 BAIAP2L2 MX2	1.95e-05	140	104	5	2c44e8cc5190226049be7ebc465d685393e701c4
Drug	m262	RGL3 LRRC4 KCNC2 KCNC3 KCNC4	1.10e-06	42	100	5	CID000009012
Drug	3,4-dihydroquinazoline	CACNA1A CACNA1E CACNA1H	1.63e-06	6	100	3	CID000583065
Drug	4-AP	CACNA1A GABRG1 CACNA1E ADORA3 KCNA7 KCNC2 KCNC3 KCNC4 KCNK3	2.08e-06	258	100	9	CID000001727
Drug	genistein	CACNA1A GABRG1 CACNA1E RGL3 RPS13 STAT2 JAK2 MAPK14 CLCA1 MAPK12 KIF15 HRAS CACNA1H NOP10 FBXO32 PLCH1 YME1L1	6.90e-06	1117	100	17	CID005280961
Drug	valproate	CACNA1A GABRG1 CACNA1E MC1R TRIM24 MTA1 MAPK14 MAPK12 KCNC4 CACNA1H	6.96e-06	381	100	10	CID000003121
Drug	pyraclofos	CACNA1A KCNA7 KCNC2 KCNC3 KCNC4 CACNA1H	7.38e-06	106	100	6	CID000093460
Drug	AC1L1IZ2	MYO5A MYO10 MC1R PORCN ADORA3 MAPK12 GTF3C1 MYO15A YME1L1	7.87e-06	304	100	9	CID000004795
Drug	AC1L2VU3	CACNA1A CACNA1E CACNA1H	1.76e-05	12	100	3	CID000129572
Drug	butamben	CACNA1A CACNA1E CACNA1H	3.60e-05	15	100	3	CID000002482
Drug	pentasulfane	CACNA1A CACNA1E CACNA1H	4.42e-05	16	100	3	CID000448216
Drug	AMP 579	ADORA3 MAPK14 MAPK12	4.42e-05	16	100	3	CID006918429
Drug	gamma-aminobutyric acid	CACNA1A GABRG1 CACNA1E PORCN GABARAP ADORA3 CLCA1 KCNC2 KCNK3 CACNA1H	4.52e-05	474	100	10	CID000000119
Disease	Familial or sporadic hemiplegic migraine	CACNA1A SCN1A	3.27e-05	3	98	2	cv:CN295307
Disease	GIANT PIGMENTED HAIRY NEVUS	MC1R HRAS	3.27e-05	3	98	2	C1842036
Disease	Familial hemiplegic migraine	CACNA1A SCN1A	3.27e-05	3	98	2	cv:C0338484
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1A CACNA1E	3.27e-05	3	98	2	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1A CACNA1E	6.52e-05	4	98	2	DOID:6364 (implicated_via_orthology)
Disease	Epilepsy, Generalized	SCN1A CACNA1H	1.62e-04	6	98	2	C0014548
Disease	epilepsy (implicated_via_orthology)	CACNA1A CACNA1E SCN11A KCNA7 SCN1A	2.17e-04	163	98	5	DOID:1826 (implicated_via_orthology)
Disease	Childhood Absence Epilepsy	CACNA1A CACNA1H	2.27e-04	7	98	2	C4281785
Disease	Epilepsy, Minor	CACNA1A CACNA1H	2.27e-04	7	98	2	C4552765
Disease	Absence Epilepsy	CACNA1A CACNA1H	2.27e-04	7	98	2	C0014553
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1A CACNA1E	2.27e-04	7	98	2	DOID:0050951 (implicated_via_orthology)
Disease	Akinetic Petit Mal	CACNA1A CACNA1H	2.27e-04	7	98	2	C0001890
Disease	Epilepsy, Absence, Atypical	CACNA1A CACNA1H	2.27e-04	7	98	2	C0751124
Disease	Absence Seizure Disorder	CACNA1A CACNA1H	2.27e-04	7	98	2	C4553705
Disease	Juvenile Absence Epilepsy	CACNA1A CACNA1H	2.27e-04	7	98	2	C4317339
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN11A SCN1A	4.83e-04	10	98	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN11A SCN1A	4.83e-04	10	98	2	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN11A SCN1A	7.05e-04	12	98	2	DOID:0060170 (implicated_via_orthology)
Disease	IGFBP-1 measurement	MYO10 TGFBRAP1	8.32e-04	13	98	2	EFO_0005118
Disease	Abnormality of chromosome segregation	MYO10 USP29 PLCH1	1.06e-03	60	98	3	HP_0002916
Disease	Liver Cirrhosis, Experimental	MYO5A METRNL SPTAN1 TRIM24 MOB3A TMBIM1 JAK2 ADORA3 HELLS	1.11e-03	774	98	9	C0023893
Disease	Lewy body measurement, Parkinson disease	TCEANC2 MX2	1.27e-03	16	98	2	EFO_0007021, MONDO_0005180
Disease	Anophthalmia-microphthalmia syndrome	PORCN VSX2	2.20e-03	21	98	2	cv:C5680330
Disease	rheumatoid arthritis, ulcerative colitis	JAK2 SNAPC4	2.20e-03	21	98	2	EFO_0000685, EFO_0000729
Disease	Ovarian Serous Adenocarcinoma	TRIM24 JAK2	2.64e-03	23	98	2	C1335177
Disease	Mechanical Allodynia	SCN11A MC1R CACNA1H	2.79e-03	84	98	3	C2936719
Disease	Allodynia	SCN11A MC1R CACNA1H	2.79e-03	84	98	3	C0458247
Disease	Hyperalgesia, Secondary	SCN11A MC1R CACNA1H	2.79e-03	84	98	3	C0751212
Disease	Hyperalgesia, Primary	SCN11A MC1R CACNA1H	2.79e-03	84	98	3	C0751211
Disease	Hyperalgesia, Thermal	SCN11A MC1R CACNA1H	2.79e-03	84	98	3	C0751214
Disease	Tactile Allodynia	SCN11A MC1R CACNA1H	2.79e-03	84	98	3	C0751213
Disease	Hyperalgesia	SCN11A MC1R CACNA1H	2.79e-03	84	98	3	C0020429
Disease	Ataxia	CACNA1A YME1L1	3.12e-03	25	98	2	C0004134

Protein segments in the cluster

Peptide	Gene	Start	Entry
SVRLYHLLRQELTKK	BOP1	601	Q14137
LRALRLLRIFKVTKY	CACNA1A	581	O00555
ILSYVKRKRFHRLSL	CFAP54	1461	Q96N23
RLRHGAALYTRKFRL	CLSTN3	766	Q9BQT9
SYFRHKERLLRISIR	CACNA1E	456	Q15878
RVKLTVRYKRVTTHR	ADORA3	111	P0DMS8
ARLVRVHAYIISYLK	EHD2	301	Q9NZN4
LQKHLALYRIRRKVT	IBA57	136	Q5T440
KIFYFLRSLHRNLLR	FBXO6	76	Q9NRD1
ATENKLRLHYRRALR	NUP93	366	Q8N1F7
FYTLVREIRQHKLRK	HRAS	156	P01112
AKIQDYHILTRKRIR	JAK2	216	O60674
YSRHRITIKKRFKVL	NOP10	41	Q9NPE3
LIYAFHSQELRRTLK	MC1R	296	Q01726
RERRKLLRFAQKHYT	OGFRL1	291	Q5TC84
TEIRYRRLQHLLEKS	HELLS	61	Q9NRZ9
RFVRILRIFKLTRHF	KCNC2	351	Q96PR1
DRKVRHTFIRKVYSI	TMBIM1	91	Q969X1
RKVAELVHFLLLKYR	MAGEA3	111	P43357
RHVCYRDSKLTFLLR	KIF15	311	Q9NS87
YLTRKRRIEVSHALA	HOXD8	221	P13378
KNLVATRRSLRIYHI	HSFX4	201	A0A1B0GTS1
RHKIILLQSRARGYL	MYO15A	1926	Q9UKN7
RSLVHAYVSRRRYLK	MYO15A	1956	Q9UKN7
SHRNFVERYKLLRRL	MYO19	661	Q96H55
RINTLVRYLLHRAKK	KCNK3	131	O14649
SIIHAKRTYRELRLL	MAPK14	61	Q16539
TVRKILSRLFRVFVH	MOB3A	151	Q96BX8
KRRYRFLAEKHLLLS	BAIAP2L2	181	Q6UXY1
YLLRHFRKQTELRRS	CCDC28A	26	Q8IWP9
VLYRRLKLFTHLRQD	JADE2	461	Q9NQC1
LGRYRVLTKHFRKEL	PNMA6E	46	A0A0J9YXQ4
RFRLLKHTRLNVVAF	NXF1	451	Q9UBU9
YRAFLLRRRFLHLKK	MYO10	776	Q9HD67
LRRRFLHLKKAAIVF	MYO10	781	Q9HD67
VFYKLRKRHQQRSTV	LRRC4	546	Q9HBW1
QALSILKHLKSYRRI	KNTC1	1551	P50748
YFLIRKRIHLRAEDA	GABARAP	61	O95166
HLRVSRLYRQKSRVF	METRNL	226	Q641Q3
YFHLLQTLKRLDRRD	FANCG	551	O15287
VYRIILHRVQRKKAL	NIM1K	386	Q8IY84
NTFLHYRTSKVRVLR	RGL3	56	Q3MIN7
KNLVATRRSLRIYHI	HSFX3	201	A0A1B0GWH4
FITYVEHVLRKRLAR	PORCN	356	Q9H237
KLRLDYRSGRFLSIH	ITPRIPL1	351	Q6GPH6
RLVRVFRIFKLSRHS	KCNA7	281	Q96RP8
VKFLTRLYEANHLIR	KLHL28	231	Q9NXS3
RIHIRIAKIDSYSRI	GABRG1	431	Q8N1C3
LLYHEKIKTSRVFIR	DHX57	1281	Q6P158
LRRRKVHREVIFKYL	C3orf38	61	Q5JPI3
RELYLKELRTQKLHT	FAM183BP	21	Q6ZVS7
QYHFSERQIRKRLIL	FBXO32	271	Q969P5
HIFRKVKRRSLRLYA	CACNA1H	466	O95180
TVRLIIRRYSSEKHY	POLI	366	Q9UNA4
VSRVRALYKRVLQLH	SDHAF3	6	Q9NRP4
YTLRNKDVRRALRHL	OR10P1	291	Q8NGE3
SVSLNKRYTRLRLIK	NLRP3	161	Q96P20
KRYTRLRLIKEHRSQ	NLRP3	166	Q96P20
LKHRELFLSRQYESL	MTA3	86	Q9BTC8
LVLRYRHKRLSYQSV	GPR137B	66	O60478
FIFLHLKRRVKSVIL	TAS2R43	116	P59537
VLRISRDSYQLLKRH	TAF5	306	Q15542
DHILRRKRRIYESLT	NUGGC	646	Q68CJ6
RVLKFSVYHVDRQRK	SYT15	226	Q9BQS2
YRRTVRALVFTLKHR	TCEANC2	171	Q96MN5
ERRKYLKHRLIVVSN	STAT2	686	P52630
LINCIVFVLRYRHKR	TMEM132E	906	Q6IEE7
FLIKLYSRSSVRRKH	TC2N	436	Q8N9U0
RTLRTKKLFHEIYLF	NGEF	506	Q8N5V2
RLHQTLCSRLLKIYR	SIN3B	786	O75182
FYLHTTKLTRIARRL	MTA1	471	Q13330
HKKYRSATRDVIFRL	TNS3	246	Q68CZ2
IIQRAYRRHLLKRTV	SCN1A	1921	P35498
YRRHLLKRTVKQASF	SCN1A	1926	P35498
VLFKKTHRILRRLFN	BRINP2	381	Q9C0B6
EHYFLGISKRDIRRL	CHST10	321	O43529
HKYIIRISTSILDLR	CLCA1	786	A8K7I4
YKKERSTQLRRFIVH	LINC01553	11	A4QN01
RKRLLAFYREKISRL	RNF212	91	Q495C1
LRRLLQKSDLYRVHF	TGFBRAP1	641	Q8WUH2
QKSDLYRVHFLLERL	TGFBRAP1	646	Q8WUH2
LYSKRLITYRLRHLL	TRIM24	376	O15164
RFEHSAKLRRKITTY	USP22	411	Q9UPT9
KVFKLLSYLTQHRRI	ZNF695	331	Q8IW36
KSFRRSSYLLIHQRV	ZNF223	351	Q9UK11
LRHTLNTLVRERKIY	STOX2	116	Q9P2F5
ILIESRIHRLARYYK	RPS13	116	P62277
RIHRLARYYKTKRVL	RPS13	121	P62277
QVLDRYHRFKELSTL	SPTAN1	21	Q13813
YHRFKELSTLRRQKL	SPTAN1	26	Q13813
RAYTLATKLRRHLKS	ZNF408	586	Q9H9D4
SRLSRVLIIHLKRYS	USP29	501	Q9HBJ7
LKIRRSLFDYHDTRI	SEPTIN8	136	Q92599
RKSLHLLLTKERYIS	POPDC2	216	Q9HBU9
KGLVRLFYLDEHRTR	PLCH1	36	Q4KWH8
YTEKLHRSSAKRLLL	TIMM21	11	Q9BVV7
IRILLRDSYERAKHI	YME1L1	721	Q96TA2
RLRKNTVKFSLYRHF	TMEM87B	381	Q96K49
KVFSRKSYLERHRRI	ZNF888	361	P0CJ79
RLKGFRVYLTLQHAR	TRIM51G	281	A0A3B3IT33
RKRTIYRFSAKHALF	SCN11A	96	Q9UI33
DRYLRRLHFSLKKGR	SNAPC4	441	Q5SXM2
LQYFSRTDRVLKHKR	ZNF148	261	Q9UQR1
LLLLNRFHVDRRSKY	GTF3C1	241	Q12789
SREIRLKRFLHVFFS	TRIP12	1181	Q14669
ALLRKRRYHAALAVL	PXMP4	16	Q9Y6I8
LRRNIVKLSLYRHFT	TMEM87A	391	Q8NBN3
RKKRRHRTIFTSYQL	VSX2	146	P58304
VRFVRILRIFKLTRH	KCNC3	416	Q14003
FVRILRIFKLTRHFV	KCNC4	351	Q03721
LFAKRAYRELRLLKH	MAPK12	66	P53778
ILKERIYRLTQARHA	MX2	691	P20592
LHNLRVRFIDSKLIY	MYO5A	86	Q9Y4I1
FLARNRYRKILREHK	MYO5A	851	Q9Y4I1