| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | pre-mRNA 3'-splice site binding | 1.08e-04 | 7 | 46 | 2 | GO:0030628 | |
| GeneOntologyBiologicalProcess | positive regulation of macropinocytosis | 4.65e-06 | 2 | 45 | 2 | GO:1905303 | |
| GeneOntologyBiologicalProcess | regulation of macropinocytosis | 1.39e-05 | 3 | 45 | 2 | GO:1905301 | |
| GeneOntologyBiologicalProcess | regulation of Fc-gamma receptor signaling pathway involved in phagocytosis | 4.63e-05 | 5 | 45 | 2 | GO:1905449 | |
| GeneOntologyBiologicalProcess | adiponectin-activated signaling pathway | 9.71e-05 | 7 | 45 | 2 | GO:0033211 | |
| GeneOntologyBiologicalProcess | positive regulation of pinocytosis | 1.29e-04 | 8 | 45 | 2 | GO:0048549 | |
| GeneOntologyBiologicalProcess | regulation of neural precursor cell proliferation | 2.12e-04 | 135 | 45 | 4 | GO:2000177 | |
| GeneOntologyBiologicalProcess | macropinocytosis | 2.53e-04 | 11 | 45 | 2 | GO:0044351 | |
| GeneOntologyBiologicalProcess | regulation of Fc receptor mediated stimulatory signaling pathway | 4.17e-04 | 14 | 45 | 2 | GO:0060368 | |
| GeneOntologyBiologicalProcess | commissural neuron axon guidance | 4.17e-04 | 14 | 45 | 2 | GO:0071679 | |
| GeneOntologyBiologicalProcess | regulation of pinocytosis | 4.17e-04 | 14 | 45 | 2 | GO:0048548 | |
| GeneOntologyBiologicalProcess | regulation of postsynaptic membrane neurotransmitter receptor levels | 4.45e-04 | 164 | 45 | 4 | GO:0099072 | |
| GeneOntologyCellularComponent | glutamatergic synapse | ARFGEF2 APPL1 LPAR2 CTNND2 AP2A1 ATAD1 ADAM10 FZD3 ITGB4 EGLN1 ITPKA | 1.16e-06 | 817 | 46 | 11 | GO:0098978 |
| GeneOntologyCellularComponent | U2AF complex | 9.88e-05 | 7 | 46 | 2 | GO:0089701 | |
| GeneOntologyCellularComponent | pinosome | 2.57e-04 | 11 | 46 | 2 | GO:0044352 | |
| GeneOntologyCellularComponent | macropinosome | 2.57e-04 | 11 | 46 | 2 | GO:0044354 | |
| GeneOntologyCellularComponent | postsynapse | 3.21e-04 | 1018 | 46 | 9 | GO:0098794 | |
| GeneOntologyCellularComponent | early phagosome | 4.24e-04 | 14 | 46 | 2 | GO:0032009 | |
| GeneOntologyCellularComponent | filopodium tip | 8.78e-04 | 20 | 46 | 2 | GO:0032433 | |
| GeneOntologyCellularComponent | endocytic vesicle | 1.50e-03 | 384 | 46 | 5 | GO:0030139 | |
| Domain | U2AF_small | 5.91e-05 | 5 | 46 | 2 | IPR009145 | |
| Pubmed | A dual-activity topoisomerase complex regulates mRNA translation and turnover. | OBSCN ARFGEF2 HSPG2 ARSJ RHBDF1 SPRED2 AP2A1 ITGB4 SPEG RYR1 SMG6 HECTD4 | 2.42e-08 | 1105 | 48 | 12 | 35748872 |
| Pubmed | Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages. | 1.87e-06 | 2 | 48 | 2 | 27219021 | |
| Pubmed | 1.87e-06 | 2 | 48 | 2 | 22340213 | ||
| Pubmed | 1.87e-06 | 2 | 48 | 2 | 23977033 | ||
| Pubmed | 1.87e-06 | 2 | 48 | 2 | 26445298 | ||
| Pubmed | 1.87e-06 | 2 | 48 | 2 | 20814572 | ||
| Pubmed | 1.87e-06 | 2 | 48 | 2 | 15185077 | ||
| Pubmed | 1.87e-06 | 2 | 48 | 2 | 32116123 | ||
| Pubmed | Characterization of U2AF(6), a splicing factor related to U2AF(35). | 5.59e-06 | 3 | 48 | 2 | 11739736 | |
| Pubmed | 5.59e-06 | 3 | 48 | 2 | 24763056 | ||
| Pubmed | 5.59e-06 | 3 | 48 | 2 | 23891720 | ||
| Pubmed | Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway. | 5.59e-06 | 3 | 48 | 2 | 25328665 | |
| Pubmed | 5.59e-06 | 3 | 48 | 2 | 18034774 | ||
| Pubmed | 5.59e-06 | 3 | 48 | 2 | 24879834 | ||
| Pubmed | Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages. | 1.12e-05 | 4 | 48 | 2 | 25568335 | |
| Pubmed | Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment. | 1.12e-05 | 4 | 48 | 2 | 21645192 | |
| Pubmed | Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells. | 1.12e-05 | 4 | 48 | 2 | 19661063 | |
| Pubmed | Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase. | 1.12e-05 | 4 | 48 | 2 | 23055524 | |
| Pubmed | 1.16e-05 | 214 | 48 | 5 | 22199357 | ||
| Pubmed | 1.86e-05 | 5 | 48 | 2 | 23145131 | ||
| Pubmed | APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. | 1.86e-05 | 5 | 48 | 2 | 16622416 | |
| Pubmed | 1.86e-05 | 5 | 48 | 2 | 26583432 | ||
| Pubmed | APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. | 1.86e-05 | 5 | 48 | 2 | 17030088 | |
| Pubmed | 1.86e-05 | 5 | 48 | 2 | 21251613 | ||
| Pubmed | Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. | 3.90e-05 | 7 | 48 | 2 | 23676497 | |
| Pubmed | 5.19e-05 | 8 | 48 | 2 | 20040596 | ||
| Pubmed | 5.19e-05 | 8 | 48 | 2 | 19433865 | ||
| Pubmed | 5.70e-05 | 1285 | 48 | 9 | 35914814 | ||
| Pubmed | 6.10e-05 | 497 | 48 | 6 | 23414517 | ||
| Pubmed | APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. | 6.67e-05 | 9 | 48 | 2 | 15016378 | |
| Pubmed | Loss of nidogen-1 and -2 results in syndactyly and changes in limb development. | 1.02e-04 | 11 | 48 | 2 | 17023412 | |
| Pubmed | Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development. | 1.22e-04 | 12 | 48 | 2 | 20665729 | |
| Pubmed | 1.22e-04 | 12 | 48 | 2 | 10433923 | ||
| Pubmed | Basement membranes in skin are differently affected by lack of nidogen 1 and 2. | 1.44e-04 | 13 | 48 | 2 | 18356808 | |
| Pubmed | The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer. | 1.55e-04 | 75 | 48 | 3 | 37298722 | |
| Pubmed | 2.21e-04 | 16 | 48 | 2 | 24305805 | ||
| Pubmed | Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. | 2.21e-04 | 16 | 48 | 2 | 21067603 | |
| Pubmed | METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis. | 2.93e-04 | 231 | 48 | 4 | 36597993 | |
| Pubmed | 3.69e-04 | 446 | 48 | 5 | 24255178 | ||
| Pubmed | 3.85e-04 | 21 | 48 | 2 | 27856617 | ||
| Pubmed | 4.63e-04 | 23 | 48 | 2 | 20696395 | ||
| Pubmed | Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate. | 5.60e-04 | 116 | 48 | 3 | 27576135 | |
| Pubmed | Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. | 6.14e-04 | 281 | 48 | 4 | 28706196 | |
| Pubmed | Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier. | 6.40e-04 | 27 | 48 | 2 | 31541017 | |
| Pubmed | 8.45e-04 | 31 | 48 | 2 | 22274697 | ||
| Pubmed | 9.67e-04 | 140 | 48 | 3 | 26930384 | ||
| Pubmed | 1.03e-03 | 323 | 48 | 4 | 24797263 | ||
| Pubmed | Transcriptional analysis of cleft palate in TGFβ3 mutant mice. | 1.08e-03 | 35 | 48 | 2 | 32913205 | |
| Pubmed | 1.14e-03 | 148 | 48 | 3 | 35676246 | ||
| Pubmed | Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins. | 1.27e-03 | 38 | 48 | 2 | 23537643 | |
| Pubmed | Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. | 1.27e-03 | 38 | 48 | 2 | 29743679 | |
| Pubmed | 1.31e-03 | 591 | 48 | 5 | 15231748 | ||
| Cytoband | 19q13.1 | 1.53e-03 | 55 | 48 | 2 | 19q13.1 | |
| GeneFamily | X-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing | 5.14e-04 | 17 | 36 | 2 | 1291 | |
| ToppCell | renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_low-phase|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group | 4.80e-07 | 144 | 48 | 5 | f6061dd965a2b2fe6ad864f8aecc06d2e74881ce | |
| ToppCell | Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr|Frontal_cortex / BrainAtlas - Mouse McCarroll V32 | 1.95e-05 | 148 | 48 | 4 | 223d6a640f3c34e73646a615593b9c0b4a4cbd6f | |
| ToppCell | severe_COVID-19-cDC|severe_COVID-19 / disease group, cell group and cell class (v2) | 2.46e-05 | 157 | 48 | 4 | ec1978e07e2214048d015d8bb793c1d9991f6e37 | |
| ToppCell | PBMC-Mild-Myeloid-cDC-cDC-cDC_6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09) | 2.65e-05 | 160 | 48 | 4 | a90eb621481fd07a821495db07d1032e109fd386 | |
| ToppCell | AT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id | 3.52e-05 | 172 | 48 | 4 | 0be41df5d35d818deb7316ac21c9366eb4b7bfd1 | |
| ToppCell | Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types | 4.02e-05 | 178 | 48 | 4 | ccea3c8908d72f5fecd151a133048c8e9758304c | |
| ToppCell | Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types | 4.11e-05 | 179 | 48 | 4 | 9ba8693fba2175bca9ff9735cc04e657abeb9084 | |
| ToppCell | Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types | 4.48e-05 | 183 | 48 | 4 | 1645d4a55cd8c22d6eb47fc5c6b1e576c454f111 | |
| ToppCell | Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types | 4.58e-05 | 184 | 48 | 4 | 34e316ad8e7b8667cd8ad61397281802a252744f | |
| ToppCell | 5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract | 5.85e-05 | 196 | 48 | 4 | ee89f6884aea11aefeaabe043db7f80145dcdf7f | |
| ToppCell | 5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract | 5.85e-05 | 196 | 48 | 4 | e75c36cb042342d69a593fb1ce62fab033889871 | |
| ToppCell | Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group | 6.08e-05 | 198 | 48 | 4 | 399760b6b6fef8639ded53b14f251b9fce600e81 | |
| ToppCell | BAL-Severe-Epithelial-Epithelial-AT1/AT2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01) | 6.08e-05 | 198 | 48 | 4 | aed0476248e9637897eefb1623ec4035f2dacd82 | |
| ToppCell | BAL-Severe-Epithelial-Epithelial-AT1/AT2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01) | 6.08e-05 | 198 | 48 | 4 | 691a2f1779225e5519155460eeb6a2aac5f67a92 | |
| ToppCell | BAL-Severe-Epithelial-Epithelial-AT1/AT2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09) | 6.08e-05 | 198 | 48 | 4 | e115eea04012e9e492e923ed080e1723c38d14fd | |
| ToppCell | BAL-Severe-Epithelial-Epithelial-AT1/AT2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09) | 6.08e-05 | 198 | 48 | 4 | 33d1e0b6f57663544bee0ffdde83a65da764d44c | |
| ToppCell | Severe_COVID-19-Epithelial-AT1/AT2|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30） | 6.08e-05 | 198 | 48 | 4 | 43e33d28d9de5033bd00d39be953542a225236ed | |
| ToppCell | medial-2-Epithelial-Alveolar_Epithelial_Type_1|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed) | 6.20e-05 | 199 | 48 | 4 | 456460c761e26ed4b1d88d9bee4d2a7c9bd9d416 | |
| ToppCell | medial-Epithelial-Alveolar_Epithelial_Type_1|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed) | 6.20e-05 | 199 | 48 | 4 | c11365653c69a5dfb37946231f8af05149a61a71 | |
| ToppCell | medial-Epithelial-Alveolar_Epithelial_Type_1-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed) | 6.20e-05 | 199 | 48 | 4 | 5263338242f95c04690d0795749ccc20b0d19f7a | |
| ToppCell | Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01) | 6.33e-05 | 200 | 48 | 4 | 8cfbde43c5e66269ad128aa5398b1517667d7d36 | |
| ToppCell | Parenchyma_COVID-19-Epithelial-TX-Basal_1|Parenchyma_COVID-19 / Sample group, Lineage and Cell type | 6.33e-05 | 200 | 48 | 4 | 592c7c3ded409a9957cbcdc62fcc213fa8eae598 | |
| ToppCell | Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09) | 6.33e-05 | 200 | 48 | 4 | 61811380d9252f12f27b7ad4752380b52692677f | |
| ToppCell | Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)|Hippocampus / BrainAtlas - Mouse McCarroll V32 | 1.21e-04 | 89 | 48 | 3 | b66575739cb5b89234bbb8a3ea2f244e0bd19cff | |
| ToppCell | Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-|Hippocampus / BrainAtlas - Mouse McCarroll V32 | 1.21e-04 | 89 | 48 | 3 | 26f01e8530b313dd5e95ea6c20fa362e34b9ed24 | |
| Disease | Myopathy, Centronuclear, Autosomal Recessive | 1.36e-05 | 4 | 45 | 2 | C0410204 | |
| Disease | Kunitz-type protease inhibitor 2 measurement | 1.02e-04 | 10 | 45 | 2 | EFO_0008200 | |
| Disease | Autosomal Recessive Centronuclear Myopathy | 2.36e-04 | 15 | 45 | 2 | C3645536 | |
| Disease | von Willebrand factor measurement, coronary artery disease | 7.83e-04 | 118 | 45 | 3 | EFO_0001645, EFO_0004629 | |
| Disease | cortical thickness | 1.38e-03 | 1113 | 45 | 7 | EFO_0004840 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| QRCMICQGDIARYRE | 726 | Q86US8 | |
| SALRDDVLCARMLYN | 221 | Q9H672 | |
| RGYCDVFMRCRLVDA | 636 | O14672 | |
| CCLRILFRMYVDENR | 1661 | Q9Y6D5 | |
| RQRAADLLYAMCDRS | 386 | O95782 | |
| TEMESYRCRLAAALC | 651 | A6NC57 | |
| RRMRECDGLTDALLY | 731 | Q9UQB3 | |
| EYRCDRRPDCRDMSD | 216 | P98160 | |
| RRPDCRDMSDELNCE | 221 | P98160 | |
| AHLEYCCQRRLDDRM | 106 | Q8TAE7 | |
| CCQRRLDDRMSDTYT | 111 | Q8TAE7 | |
| YLNRCMDQERLRRES | 141 | O14526 | |
| DAEMRRTFRRLLCCA | 296 | Q9HBW0 | |
| RMNRLDQCYCERTCT | 261 | Q99435 | |
| RRYAAMLSCLDEAIN | 291 | Q5FYB0 | |
| DNCSVMAVDCEDRRY | 326 | Q9UKG1 | |
| NYCRIARELRVSCMQ | 41 | Q8NA75 | |
| RCYRQELCKLMCERL | 1711 | Q5VYK3 | |
| DENCLRKYRRQCMQD | 86 | P20941 | |
| AAMRLGAECARYRAC | 401 | Q2M1P5 | |
| ERCLDSVMCYDRLSF | 426 | Q2TBA0 | |
| QCERLRMLYRDCARP | 1911 | Q9Y4D8 | |
| LLRCEAALARLYCRM | 2436 | Q9Y4D8 | |
| CDMNDCYSRLRRLVP | 66 | P47928 | |
| RRCYEEAAEMDCLQD | 121 | Q02509 | |
| KDCAYCTDEMFRDRR | 46 | P16144 | |
| RMCRCLREEDRSLNQ | 386 | P30307 | |
| CSEPERYCLARLMAD | 211 | P23677 | |
| RYCLARLMADALRGC | 216 | P23677 | |
| DRYCLRQDGAMCELQ | 3316 | Q5VST9 | |
| VFRYLSRRELCECMR | 901 | Q9Y2K7 | |
| RQNCYSVCDIMRLGR | 291 | Q6IN97 | |
| DNCSVMAVDCEDRRY | 326 | Q8NEU8 | |
| NDALSCEYECRRRML | 211 | Q52LJ0 | |
| CEYECRRRMLMKRLD | 216 | Q52LJ0 | |
| RDRQYCELCGKMENL | 16 | Q9GZT9 | |
| RLCQRAYSECSKLME | 101 | Q9NPG1 | |
| RPYKCDQCSREFMRS | 341 | Q5JT82 | |
| DVIEDCLMSLCRYIR | 2601 | P21817 | |
| CMERQLEAARYRSDG | 26 | Q9BQA1 | |
| EKMRALCADEYRARC | 326 | O14654 | |
| CCESDAQRRASEYMQ | 196 | Q6ZN16 | |
| RYMDSRECLLFKNEC | 136 | Q86YW0 | |
| RCEITSREYCDFMRG | 606 | Q96CC6 | |
| EMCRDAALLCVREYV | 301 | Q8NBU5 | |
| NRREKCTYCRRHFMS | 711 | Q13129 | |
| QYCLRICRVSRRDMG | 1446 | Q15772 | |
| NSYRSEEACMLRCFR | 171 | O43291 | |
| SDRSVIERDMCTYCR | 611 | O95171 | |
| KEDGERSRCVYCRDM | 301 | Q7Z698 | |
| REACCRQYEMGECTR | 151 | Q01081 | |
| RESCCRQYEMGECTR | 151 | Q8WU68 | |
| TCYMCVERRFGSREL | 3116 | Q96JG9 |