Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	iron ion binding	SLC11A2 CYP27B1 CYP2S1 PPEF1 CYP46A1 FTHL17 ALOX15	2.02e-05	166	100	7	GO:0005506
GeneOntologyMolecularFunction	cadmium ion transmembrane transporter activity	SLC11A2 SLC11A1	7.42e-05	3	100	2	GO:0015086
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	MYLK RPS6KC1 PIKFYVE TLK1 CAMKV CSNK1G2 PRKG1 WNK4 ALPK2 CDK7	8.05e-05	446	100	10	GO:0004674
GeneOntologyMolecularFunction	protein kinase activity	MYLK RPS6KC1 PIKFYVE TLK1 CAMKV CSNK1G2 PRKG1 WNK4 ALPK2 EPHA8 CDK7	2.07e-04	600	100	11	GO:0004672
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	CERK MYLK RPS6KC1 PIKFYVE TLK1 CAMKV CSNK1G2 PRKG1 WNK4 ALPK2 EPHA8 CDK7	2.20e-04	709	100	12	GO:0016773
GeneOntologyMolecularFunction	kinase activity	CERK MYLK RPS6KC1 PIKFYVE TLK1 CAMKV CSNK1G2 PRKG1 WNK4 ALPK2 EPHA8 CDK7	4.34e-04	764	100	12	GO:0016301
GeneOntologyMolecularFunction	protein serine kinase activity	RPS6KC1 PIKFYVE TLK1 CSNK1G2 PRKG1 WNK4 ALPK2 CDK7	4.80e-04	363	100	8	GO:0106310
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC11A2 PSEN1 SLC39A10 KCNG3 SLC13A2 SLC11A1 KCNK15 SCN2A ATP2B1	5.45e-04	465	100	9	GO:0046873
GeneOntologyMolecularFunction	aspartic endopeptidase activity, intramembrane cleaving	PSEN1 PSEN2	6.82e-04	8	100	2	GO:0042500
GeneOntologyMolecularFunction	calmodulin binding	MYLK RGS2 CAMKV SCN2A MYO1F ATP2B1	1.06e-03	230	100	6	GO:0005516
GeneOntologyMolecularFunction	manganese ion transmembrane transporter activity	SLC11A2 SLC11A1	1.09e-03	10	100	2	GO:0005384
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	1.09e-03	10	100	2	GO:0001849
GeneOntologyMolecularFunction	epoxide hydrolase activity	EPHX1 ALOX15	1.33e-03	11	100	2	GO:0004301
GeneOntologyMolecularFunction	iron ion transmembrane transporter activity	SLC11A2 SLC11A1	1.33e-03	11	100	2	GO:0005381
GeneOntologyMolecularFunction	transition metal ion transmembrane transporter activity	SLC11A2 SLC39A10 SLC11A1	1.39e-03	44	100	3	GO:0046915
GeneOntologyMolecularFunction	endopeptidase activity	ZMPSTE24 PSEN1 PSEN2 SHH UQCRC2 MMP10 MMP12 ESPL1	1.43e-03	430	100	8	GO:0004175
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	EPHX1 ALOX15	1.87e-03	13	100	2	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	EPHX1 ALOX15	1.87e-03	13	100	2	GO:0016803
MousePheno	brain lesion	COL4A1 PSEN1 PIKFYVE CLCN2 NOTCH3	8.81e-06	50	79	5	MP:0021002
Domain	Nramp	SLC11A2 SLC11A1	2.90e-05	2	101	2	PF01566
Domain	NRAMP_fam	SLC11A2 SLC11A1	2.90e-05	2	101	2	IPR001046
Domain	Presenilin	PSEN1 PSEN2	2.90e-05	2	101	2	PF01080
Domain	Peptidase_A22A	PSEN1 PSEN2	2.90e-05	2	101	2	IPR001108
Domain	Anaphylatoxin_comp_syst	C4A C4B	2.86e-04	5	101	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	2.86e-04	5	101	2	IPR001840
Domain	ANATO	C4A C4B	5.97e-04	7	101	2	SM00104
Domain	PSN	PSEN1 PSEN2	5.97e-04	7	101	2	SM00730
Domain	ANAPHYLATOXIN_2	C4A C4B	5.97e-04	7	101	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	5.97e-04	7	101	2	PS01177
Domain	ANATO	C4A C4B	5.97e-04	7	101	2	PF01821
Domain	Preselin/SPP	PSEN1 PSEN2	5.97e-04	7	101	2	IPR006639
Domain	Anaphylatoxin/fibulin	C4A C4B	5.97e-04	7	101	2	IPR000020
Domain	Kinase-like_dom	MYLK RPS6KC1 TLK1 CAMKV CSNK1G2 PRKG1 WNK4 ALPK2 EPHA8 CDK7	7.04e-04	542	101	10	IPR011009
Domain	S_TKc	MYLK RPS6KC1 TLK1 CAMKV CSNK1G2 PRKG1 WNK4 CDK7	7.37e-04	359	101	8	SM00220
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	7.94e-04	8	101	2	IPR019565
Domain	Thiol-ester_cl	C4A C4B	7.94e-04	8	101	2	PF10569
Domain	MacrogloblnA2_CS	C4A C4B	7.94e-04	8	101	2	IPR019742
Domain	Pkinase	MYLK RPS6KC1 TLK1 CAMKV CSNK1G2 PRKG1 WNK4 CDK7	1.08e-03	381	101	8	PF00069
Domain	A2M	C4A C4B	1.27e-03	10	101	2	PF00207
Domain	A2M_N_2	C4A C4B	1.27e-03	10	101	2	IPR011625
Domain	A2M_comp	C4A C4B	1.27e-03	10	101	2	IPR011626
Domain	A2M_recep	C4A C4B	1.27e-03	10	101	2	PF07677
Domain	A2M_comp	C4A C4B	1.27e-03	10	101	2	PF07678
Domain	A2M_N	C4A C4B	1.27e-03	10	101	2	PF01835
Domain	A2M_N	C4A C4B	1.27e-03	10	101	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.27e-03	10	101	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.27e-03	10	101	2	PS00477
Domain	A2M_N_2	C4A C4B	1.27e-03	10	101	2	PF07703
Domain	Macroglobln_a2	C4A C4B	1.27e-03	10	101	2	IPR001599
Domain	Prot_kinase_dom	MYLK RPS6KC1 TLK1 CAMKV CSNK1G2 PRKG1 WNK4 EPHA8 CDK7	1.33e-03	489	101	9	IPR000719
Domain	PROTEIN_KINASE_DOM	MYLK RPS6KC1 TLK1 CAMKV CSNK1G2 PRKG1 WNK4 EPHA8 CDK7	1.41e-03	493	101	9	PS50011
Domain	Cyt_P450_E_grp-I	CYP27B1 CYP2S1 CYP46A1	1.85e-03	45	101	3	IPR002401
Domain	Kelch_2	LCMT2 KLHL36	2.17e-03	13	101	2	IPR011498
Domain	Kelch_2	LCMT2 KLHL36	2.17e-03	13	101	2	PF07646
Domain	Pept_M10A_Zn_BS	MMP10 MMP12	2.90e-03	15	101	2	IPR021158
Domain	Cyt_P450_CS	CYP27B1 CYP2S1 CYP46A1	2.96e-03	53	101	3	IPR017972
Domain	Ser/Thr_kinase_AS	MYLK RPS6KC1 TLK1 CSNK1G2 PRKG1 WNK4 CDK7	3.25e-03	357	101	7	IPR008271
Domain	Kelch-typ_b-propeller	LCMT2 KBTBD4 KLHL36	3.28e-03	55	101	3	IPR015915
Domain	PROTEIN_KINASE_ATP	MYLK RPS6KC1 TLK1 CSNK1G2 PRKG1 WNK4 EPHA8 CDK7	3.45e-03	459	101	8	PS00107
Domain	PROTEIN_KINASE_ST	MYLK RPS6KC1 TLK1 CSNK1G2 PRKG1 WNK4 CDK7	3.51e-03	362	101	7	PS00108
Domain	CYTOCHROME_P450	CYP27B1 CYP2S1 CYP46A1	3.63e-03	57	101	3	PS00086
Domain	Hemopexin_CS	MMP10 MMP12	3.73e-03	17	101	2	IPR018486
Domain	C345C	C4A C4B	3.73e-03	17	101	2	SM00643
Domain	-	CYP27B1 CYP2S1 CYP46A1	3.82e-03	58	101	3	1.10.630.10
Domain	p450	CYP27B1 CYP2S1 CYP46A1	3.82e-03	58	101	3	PF00067
Domain	Pept_M10A_stromelysin-type	MMP10 MMP12	4.19e-03	18	101	2	IPR016293
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	4.19e-03	18	101	2	IPR008930
Domain	Cyt_P450	CYP27B1 CYP2S1 CYP46A1	4.20e-03	60	101	3	IPR001128
Domain	NTR	C4A C4B	4.66e-03	19	101	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	4.66e-03	19	101	2	IPR018933
Domain	PG_binding_1	MMP10 MMP12	5.16e-03	20	101	2	PF01471
Domain	Peptidoglycan-bd-like	MMP10 MMP12	5.16e-03	20	101	2	IPR002477
Pathway	REACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3	PSEN1 PSEN2 NOTCH3	9.66e-06	8	80	3	M27887
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION	PSEN1 PSEN2 NOTCH3	2.81e-05	11	80	3	M47865
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B C7	2.81e-05	11	80	3	MM1430
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B C7	3.73e-05	12	80	3	MM1368
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B C7	4.83e-05	13	80	3	M4732
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B C7	7.62e-05	15	80	3	M7146
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B C7	1.13e-04	17	80	3	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B C7	1.13e-04	17	80	3	MM1369
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B C7	1.87e-04	20	80	3	M917
Pathway	WP_COMPLEMENT_ACTIVATION	C4A C4B C7	2.51e-04	22	80	3	M39502
Pathway	REACTOME_METAL_ION_SLC_TRANSPORTERS	SLC11A2 SLC39A10 SLC11A1	3.27e-04	24	80	3	M18795
Pathway	REACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS	PSEN1 PSEN2 NOTCH3	3.70e-04	25	80	3	M27879
Pathway	WP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING	PSEN1 PSEN2 NOTCH3	4.67e-04	27	80	3	M39545
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	6.56e-04	7	80	2	MM14685
Pathway	REACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3	PSEN1 NOTCH3	6.56e-04	7	80	2	MM15612
Pathway	REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS	PSEN1 PSEN2 ARRB1	7.05e-04	31	80	3	M592
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	8.71e-04	8	80	2	M47872
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	8.71e-04	8	80	2	M27031
Pathway	REACTOME_INTERLEUKIN_23_SIGNALING	IL23A P4HB	8.71e-04	8	80	2	MM15619
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ABCF3 ZMPSTE24 CYP27B1 NASP CEP192 SEC31A SLC39A10 LCMT2 RPS6KC1 KMT2C TYW1B P4HB EIF4B ESPL1 ATP2B1 CNOT2	1.26e-07	1084	103	16	11544199
Pubmed	Interactions among genetic variants from contractile pathway of vascular smooth muscle cell in essential hypertension susceptibility of Chinese Han population.	MYLK RGS2 PRKG1	2.51e-07	5	103	3	18496125
Pubmed	Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.	PSEN1 PSEN2 NOTCH3	5.01e-07	6	103	3	19573812
Pubmed	Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.	PSEN1 PSEN2 NOTCH3	8.75e-07	7	103	3	11518718
Pubmed	Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis.	PSEN1 PSEN2 NOTCH3	8.75e-07	7	103	3	16169548
Pubmed	Mice lacking both presenilin genes exhibit early embryonic patterning defects.	PSEN1 PSEN2 SHH	1.40e-06	8	103	3	10557208
Pubmed	Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.	PSEN1 PSEN2 NOTCH3	2.09e-06	9	103	3	18507503
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	IFT81 NASP EXOC3 KMT2C VPS13D GAR1 EIF4B C4A C4B WNK4	2.34e-06	497	103	10	36774506
Pubmed	Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.	PSEN1 PSEN2 CYP46A1 C7	2.45e-06	32	103	4	18842294
Pubmed	gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.	PSEN1 PSEN2 NOTCH3	2.98e-06	10	103	3	15525534
Pubmed	A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo.	PSEN1 PSEN2 SHH	7.06e-06	13	103	3	25995356
Pubmed	JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency.	PSEN1 PSEN2 NOTCH3	7.06e-06	13	103	3	34990407
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	8.69e-06	2	103	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	8.69e-06	2	103	2	16565498
Pubmed	Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.	PSEN1 PSEN2	8.69e-06	2	103	2	21285369
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	8.69e-06	2	103	2	15998580
Pubmed	Novel PSEN1 and PSEN2 Mutations Identified in Sporadic Early-onset Alzheimer Disease and Posterior Cortical Atrophy.	PSEN1 PSEN2	8.69e-06	2	103	2	33973882
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	8.69e-06	2	103	2	19062096
Pubmed	Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.	PSEN1 PSEN2	8.69e-06	2	103	2	12460542
Pubmed	Enhanced 15-Lipoxygenase 1 Production is Related to Periostin Expression and Eosinophil Recruitment in Eosinophilic Chronic Rhinosinusitis.	POSTN ALOX15	8.69e-06	2	103	2	33218117
Pubmed	Alzheimer's Disease Associated Presenilin 1 and 2 Genes Dysregulation in Neonatal Lymphocytes Following Perinatal Asphyxia.	PSEN1 PSEN2	8.69e-06	2	103	2	34067945
Pubmed	Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus.	PSEN1 PSEN2	8.69e-06	2	103	2	36710361
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	8.69e-06	2	103	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	8.69e-06	2	103	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	8.69e-06	2	103	2	17645767
Pubmed	Binding of transcription factors to Presenilin 1 and 2 promoter cis-acting elements varies during the development of mouse cerebral cortex.	PSEN1 PSEN2	8.69e-06	2	103	2	27177724
Pubmed	Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts.	PSEN1 PSEN2	8.69e-06	2	103	2	11715026
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	8.69e-06	2	103	2	12207352
Pubmed	Clinical Phenotype and Mutation Spectrum of Alzheimer's Disease with Causative Genetic Mutation in a Chinese Cohort.	PSEN1 PSEN2	8.69e-06	2	103	2	34102969
Pubmed	Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B.	KIR2DL5B KIR2DL5A	8.69e-06	2	103	2	12185535
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	8.69e-06	2	103	2	27758680
Pubmed	Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.	PSEN1 PSEN2	8.69e-06	2	103	2	23365231
Pubmed	Changes in cholesterol metabolism are associated with PS1 and PS2 gene regulation in SK-N-BE.	PSEN1 PSEN2	8.69e-06	2	103	2	17401156
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	8.69e-06	2	103	2	22387014
Pubmed	SLC11A1 (NRAMP1) but not SLC11A2 (NRAMP2) polymorphisms are associated with susceptibility to tuberculosis in a high-incidence community in South Africa.	SLC11A2 SLC11A1	8.69e-06	2	103	2	15636493
Pubmed	Identification of Structural Calcium Binding Sites in Membrane-Bound Presenilin 1 and 2.	PSEN1 PSEN2	8.69e-06	2	103	2	32420742
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	8.69e-06	2	103	2	23749435
Pubmed	Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro.	PSEN1 PSEN2	8.69e-06	2	103	2	33413468
Pubmed	Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene.	KIR2DL5B KIR2DL5A	8.69e-06	2	103	2	11086080
Pubmed	Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.	PSEN1 PSEN2	8.69e-06	2	103	2	31167792
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	8.69e-06	2	103	2	23918728
Pubmed	Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism.	PSEN1 PSEN2	8.69e-06	2	103	2	18367332
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	8.69e-06	2	103	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	8.69e-06	2	103	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	8.69e-06	2	103	2	4216347
Pubmed	Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.	PSEN1 PSEN2	8.69e-06	2	103	2	29078389
Pubmed	Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.	PSEN1 PSEN2	8.69e-06	2	103	2	19834068
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	8.69e-06	2	103	2	6950384
Pubmed	Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.	PSEN1 PSEN2	8.69e-06	2	103	2	18971484
Pubmed	Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications.	PSEN1 PSEN2	8.69e-06	2	103	2	38227890
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	8.69e-06	2	103	2	8660986
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	8.69e-06	2	103	2	8428773
Pubmed	Epigenetic regulation of presenilin 1 and 2 in the cerebral cortex of mice during development.	PSEN1 PSEN2	8.69e-06	2	103	2	25652771
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	8.69e-06	2	103	2	24638111
Pubmed	Loss of presenilin function enhances tau phosphorylation and aggregation in mice.	PSEN1 PSEN2	8.69e-06	2	103	2	34593029
Pubmed	Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels.	PSEN1 PSEN2	8.69e-06	2	103	2	25204494
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	8.69e-06	2	103	2	21345967
Pubmed	β-Arrestin-1 links mitogenic sonic hedgehog signaling to the cell cycle exit machinery in neural precursors.	SHH ARRB1	8.69e-06	2	103	2	20935513
Pubmed	Increased inflammatory response both in brain and in periphery in presenilin 1 and presenilin 2 conditional double knock-out mice.	PSEN1 PSEN2	8.69e-06	2	103	2	19584449
Pubmed	Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway.	PSEN1 PSEN2	8.69e-06	2	103	2	28619096
Pubmed	Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.	PSEN1 PSEN2	8.69e-06	2	103	2	8574969
Pubmed	In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.	PSEN1 PSEN2	8.69e-06	2	103	2	12846562
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	8.69e-06	2	103	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	8.69e-06	2	103	2	2302180
Pubmed	Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling.	SLC11A2 SLC11A1	8.69e-06	2	103	2	20394798
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	8.69e-06	2	103	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	8.69e-06	2	103	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	8.69e-06	2	103	2	29080553
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	8.69e-06	2	103	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	8.69e-06	2	103	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	8.69e-06	2	103	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	8.69e-06	2	103	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	8.69e-06	2	103	2	6149581
Pubmed	Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.	PSEN1 PSEN2	8.69e-06	2	103	2	37864790
Pubmed	Ibuprofen partially attenuates neurodegenerative symptoms in presenilin conditional double-knockout mice.	PSEN1 PSEN2	8.69e-06	2	103	2	24699228
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	8.69e-06	2	103	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	8.69e-06	2	103	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	8.69e-06	2	103	2	2387317
Pubmed	Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.	RGS2 PRKG1	8.69e-06	2	103	2	14608379
Pubmed	Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.	PSEN1 PSEN2	8.69e-06	2	103	2	15287885
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	8.69e-06	2	103	2	16908004
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	8.69e-06	2	103	2	7365238
Pubmed	Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4.	KIR2DL5B KIR2DL5A	8.69e-06	2	103	2	17215859
Pubmed	A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.	PSEN1 PSEN2	8.69e-06	2	103	2	15537629
Pubmed	Inhibition of cGMP-dependent protein kinase reduces the response to sonic hedgehog in neuralized embryoid bodies.	SHH PRKG1	8.69e-06	2	103	2	17105400
Pubmed	Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.	PSEN1 PSEN2	8.69e-06	2	103	2	12885769
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	8.69e-06	2	103	2	7391573
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	8.69e-06	2	103	2	17971360
Pubmed	Age and sex dependent alteration in presenilin expression in mouse cerebral cortex.	PSEN1 PSEN2	8.69e-06	2	103	2	17874292
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	8.69e-06	2	103	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	8.69e-06	2	103	2	17971229
Pubmed	Two homologous genes causing early-onset familial Alzheimer's disease.	PSEN1 PSEN2	8.69e-06	2	103	2	9246482
Pubmed	A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.	PSEN1 PSEN2	8.69e-06	2	103	2	16103124
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	8.69e-06	2	103	2	6881182
Pubmed	Dimorphic effects of Notch signaling in bone homeostasis.	PSEN1 PSEN2	8.69e-06	2	103	2	18297084
Pubmed	Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.	PSEN1 PSEN2	8.69e-06	2	103	2	15128703
Pubmed	Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.	PSEN1 PSEN2	8.69e-06	2	103	2	21914807
Pubmed	Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population.	SLC11A2 SLC11A1	8.69e-06	2	103	2	33781609
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	8.69e-06	2	103	2	17921792
Pubmed	Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.	PSEN1 PSEN2	8.69e-06	2	103	2	17614943
Interaction	PRKCSH interactions	MYLK NASP RGS2 EDEM3 NCAPG NOP14 P4HB UQCRC2 EPHA8	5.83e-06	257	101	9	int:PRKCSH
GeneFamily	Complement system\|Sushi domain containing	C4A C4B C7	3.32e-04	36	68	3	492
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	4.93e-04	9	68	2	1234
GeneFamily	CD molecules\|Killer cell immunoglobulin like receptors	KIR2DL5B KIR2DL5A	2.05e-03	18	68	2	620
Coexpression	GSE44649_WT_VS_MIR155_KO_NAIVE_CD8_TCELL_UP	PSEN2 RENBP SLC13A2 ARRB1 CAMKV PNPLA3 EPHA8	1.27e-05	198	102	7	M9778
Coexpression	GSE37301_LYMPHOID_PRIMED_MPP_VS_RAG2_KO_NK_CELL_UP	MYLK SRSF6 CYP27B1 RGS2 GAR1 UQCRC2 MAPRE2	1.31e-05	199	102	7	M8863
Coexpression	MENON_FETAL_KIDNEY_3_STROMAL_CELLS	COL4A1 MYL6 MYLK POSTN ATP2B1	1.64e-05	81	102	5	M39253
ToppCell	Dendritic_Cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	CYP27B1 CYP2S1 RGS2 MYO1F AP1S2 PRAME	3.84e-06	183	101	6	499da89b4abe7b746e703cd1e5c56f9b1d97ac3c
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 MYLK POSTN PNPLA3 PRKG1 NOTCH3	4.62e-06	189	101	6	ca3a04c202afc32aa11d17154066ef7dc6d01405
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 EPHX1 POSTN PRKG1 MAPRE2 NOTCH3	5.69e-06	196	101	6	6708026bafd19c35c5c4e81911344d36a0f508cd
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 MYL6 MYLK POSTN PRKG1 NOTCH3	6.03e-06	198	101	6	b258f672529fb2c03e62e2696d335043c4963280
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SGO1 POSTN NCAPG AP1S2 MAPRE2 ALOX15	6.03e-06	198	101	6	a11ac83dbd69d1c068971266d7c7343d114a6294
ToppCell	metastatic_Brain-Fibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	COL4A1 MYLK POSTN PRKG1 C7 NOTCH3	6.21e-06	199	101	6	63eb2106bb6e2e33d020628583536c8d96662c84
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Monocytic-Monocyte_CD14\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HPSE RGS2 SLC11A1 MYO1F AP1S2 ATP2B1	6.39e-06	200	101	6	47a3fd432c35958c5d478d34f5e0355e39ed0aba
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Monocytic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HPSE RGS2 SLC11A1 MYO1F AP1S2 ATP2B1	6.39e-06	200	101	6	d237cf947d6768b022d18211e14af4adb4990708
ToppCell	Bronchus_Control_(B.)-Immune-TX-MoAM-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	HPSE RGS2 SLC11A1 MYO1F AP1S2 ATP2B1	6.39e-06	200	101	6	fe7f8b04067b6680b69c8523f0fa514ef97207e2
ToppCell	facs-Heart-Unknown-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH2A CYP27B1 LAMA1 WNK4 EPHA8	1.81e-05	142	101	5	759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SHH KCNG3 CLCN2 ATP2B1 EPHA8	1.94e-05	144	101	5	08005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCell	droplet-Kidney-nan-18m-Myeloid-CD45____macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 RGS2 SLC11A1 MYO1F MMP12	3.21e-05	160	101	5	d18c4cc99a31481dd0ee8af9299695d5f6857b42
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYL6 MYLK IFT81 RGS2 POSTN	3.21e-05	160	101	5	8624f101828efd32cdd38a65df8d94d690720a63
ToppCell	droplet-Kidney-nan-18m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 RGS2 SLC11A1 MYO1F MMP12	3.21e-05	160	101	5	a707a4ad9fbedcca227f76b49f1393e88101c2fb
ToppCell	droplet-Kidney-nan-18m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 RGS2 SLC11A1 MYO1F MMP12	3.21e-05	160	101	5	73b604cbdcd9e8f0f317964abc632abee314a557
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYL6 MYLK IFT81 RGS2 POSTN	3.21e-05	160	101	5	9de3dd6b9d4b51314d60b3b01f4132bcfa2dfc18
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZMYND15 CFAP47 DENND1C GAR1 TRABD	3.41e-05	162	101	5	388670cf3acef17df971c0d8ae3ce14398945192
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZMYND15 CFAP47 DENND1C GAR1 TRABD	3.41e-05	162	101	5	9333d923225df7bfdf6b3a4c32816751315aec50
ToppCell	droplet-Kidney-nan-3m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 RGS2 SLC11A1 MYO1F MMP12	3.83e-05	166	101	5	961f93f7fb127f449cb1021f6ba73775dc666c53
ToppCell	droplet-Kidney-nan-3m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 RGS2 SLC11A1 MYO1F MMP12	3.83e-05	166	101	5	fc71e871084299fb6f006c76f91e72026a290149
ToppCell	droplet-Kidney-nan-3m-Myeloid-CD45____macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 RGS2 SLC11A1 MYO1F MMP12	3.83e-05	166	101	5	f55fc58572ae6080ac2758462a6b1f3f8b5a93f3
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHX1 CLSTN3 C7 ALPK2 NOTCH3	4.17e-05	169	101	5	559e98216720e4babf0b0941100f1b485c35b11b
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYL6 SLC13A2 CLCN2 PLEKHG6 ATP2B1	4.41e-05	171	101	5	e7dbee63cc39230aa12e7868ec78a129160c0d22
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-Enterocyte\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYL6 SLC13A2 CLCN2 PLEKHG6 ATP2B1	4.41e-05	171	101	5	b0d616699e2110ffd6cf1868ed1f1a29f824e1fc
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 NASP POSTN PRKG1 NOTCH3	4.54e-05	172	101	5	03a0aff6b7971093a4347b5ed12546d78374c56f
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 SGO1 POSTN ESPL1 NOTCH3	4.92e-05	175	101	5	fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	POSTN NOP14 PRKG1 C7 NOTCH3	4.92e-05	175	101	5	12f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 SGO1 POSTN NCAPG PRKG1	4.92e-05	175	101	5	3e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK SLC13A2 CLCN2 PLEKHG6 ATP2B1	5.06e-05	176	101	5	7622f5a8e7320cc7b593141854107ecaf4adff7f
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SGO1 POSTN NCAPG ESPL1 NOTCH3	5.06e-05	176	101	5	45c6983ab671b0f306e7390320bd84f848e474cc
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 MYLK POSTN PRKG1 NOTCH3	5.48e-05	179	101	5	56db12467b445f2b8ef92af50779eeab10413eb2
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGO1 NCAPG C4A ESPL1 NOTCH3	5.93e-05	182	101	5	39f9b3eb22293cc27c6e175702c77d1eeb24fdc9
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SGO1 PPEF1 POSTN NCAPG NOTCH3	6.25e-05	184	101	5	d1e0e3b0eed2db8a5b7e3d6f81294667e4ba64e5
ToppCell	368C-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	EPHX1 NASP UPF3A NCAPG	6.25e-05	94	101	4	56176a9435ef197f07034bbbd16b85016a89ad3c
ToppCell	facs-Heart-RA-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLSTN3 MYLK POSTN PRKG1 NOTCH3	6.41e-05	185	101	5	c4ef8d9f8b9769e887daac4efd9dc05738b28ae2
ToppCell	facs-Heart-RA-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLSTN3 MYLK POSTN PRKG1 NOTCH3	6.41e-05	185	101	5	10ddf38d908525b4258f9d2da8be4c56ebc08ff4
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK CYP46A1 POSTN PRKG1 NOTCH3	6.57e-05	186	101	5	e2ba9f3518d87a44537a57a648df17ab98fbbb39
ToppCell	facs-Heart-LA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYLK CYP46A1 POSTN PRKG1 NOTCH3	6.57e-05	186	101	5	fda3415222f688ef5cd8de4b0b79daa2493c585f
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PPEF1 POSTN CAMKV AP1S2 MAPRE2	6.74e-05	187	101	5	dfc2b95d70daf533bc0cc4ce78af9f65dd75a25b
ToppCell	droplet-Liver-HEPATOCYTES-1m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3TC2 IFT81 LAMA1 POSTN NOTCH3	6.74e-05	187	101	5	b6ecf55014f246461bf1ca12f24cb4d046661fa4
ToppCell	droplet-Liver-HEPATOCYTES-1m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3TC2 IFT81 LAMA1 POSTN NOTCH3	6.74e-05	187	101	5	9fb15f24b9b364b0c4704ec98aec236eaec5411c
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	COL4A1 MYLK POSTN PRKG1 NOTCH3	6.74e-05	187	101	5	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	droplet-Liver-HEPATOCYTES-1m-Mesenchymal\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3TC2 IFT81 LAMA1 POSTN NOTCH3	6.74e-05	187	101	5	e6afbaed352310a1cb49571a2aae18be1f533c9a
ToppCell	IPF-Stromal-SMC\|World / Disease state, Lineage and Cell class	COL4A1 MYLK C4B PRKG1 NOTCH3	6.91e-05	188	101	5	b66264e8f8d536ed2beec31e6746c687718f239b
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYLK LCMT2 PRKG1 NOTCH3 RBM38	6.91e-05	188	101	5	a5e7a363fbd5ae4d9312cf6f9941413d6a5c0b4d
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 EPHX1 POSTN PRKG1 NOTCH3	6.91e-05	188	101	5	a906c29e3fda22eecfec3e5cac706c417bf2b7a4
ToppCell	IPF-Stromal-SMC\|IPF / Disease state, Lineage and Cell class	COL4A1 MYLK C4B PRKG1 NOTCH3	6.91e-05	188	101	5	e98b24c0de41285f01f7ac194ff0a1b59fd5c333
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL4A1 EPHX1 POSTN PRKG1 NOTCH3	7.09e-05	189	101	5	26cfe5b7e7f477f225f4e9f25f983f432f01e183
ToppCell	5'-Adult-Distal_Rectal-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZMPSTE24 CYP2S1 HPSE SLC11A1 TRABD	7.09e-05	189	101	5	9e3c083174a64ea78648c6d48498fc4e721b569f
ToppCell	5'-Adult-Distal_Rectal-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZMPSTE24 CYP2S1 HPSE SLC11A1 TRABD	7.09e-05	189	101	5	6e19bfa52406ebe095daa99f958ec4d596ce6e39
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 EPHX1 PSEN2 ARRB1 WNK4	7.09e-05	189	101	5	1137583e21d874c201c20581ba1995e2bfa3de59
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL4A1 EPHX1 POSTN PRKG1 NOTCH3	7.27e-05	190	101	5	2ab604d35456beba71c25511e0f819000e6642d2
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 EPHX1 PSEN2 ARRB1 WNK4	7.27e-05	190	101	5	7068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_2\|Striatum / BrainAtlas - Mouse McCarroll V32	IL23A C4A PNPLA3 C7	7.35e-05	98	101	4	7a62a77ca83153dacff4d02d6e32104227d0980d
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocye.Tnr.Pdgfa_(Pdgfa)\|Striatum / BrainAtlas - Mouse McCarroll V32	IL23A C4A PNPLA3 C7	7.35e-05	98	101	4	26250ea4171a0557a67505839cf79d3fe4d9d41a
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr\|Striatum / BrainAtlas - Mouse McCarroll V32	IL23A C4A PNPLA3 C7	7.35e-05	98	101	4	42875d16ae9fcbaf988cd71be82568f2f862f2dd
ToppCell	(11)_FOXN4+-(0)_Reference\|(11)_FOXN4+ / shred by cell type by condition	EPHX1 CLCN2 TRABD MYO1F ALOX15	7.64e-05	192	101	5	ef06f96b934dd05b40025f8215b6d919d3a17045
ToppCell	Fibroblast-D_(Pericyte)\|World / shred on cell class and cell subclass (v4)	COL4A1 MYLK POSTN PRKG1 NOTCH3	7.64e-05	192	101	5	8c13c351fcc3d88e8c2ffa017e71ff6272cc6fac
ToppCell	droplet-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A1 MYLK POSTN SLC11A1 NOTCH3	7.64e-05	192	101	5	a804cb101c3a5585f72217e1143584b1ca436724
ToppCell	P15-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYL6 MYLK POSTN SLC11A1 NOTCH3	7.64e-05	192	101	5	a476895b7b252c388d6346eacbc72f0115b1443e
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYL6 MYLK POSTN PRKG1 NOTCH3	7.82e-05	193	101	5	88916d9a7d831eb52848599917c04238f8f9812b
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 MYLK POSTN PRKG1 NOTCH3	7.82e-05	193	101	5	800b0f5705fefcd3608e37801afae8a94474723e
ToppCell	IIH\|World / Condition, Cell_class and T cell subcluster	CYP46A1 RGS2 SLC11A1 MYO1F AP1S2	7.82e-05	193	101	5	a9af5ccff108d51939ead130583f5b950d3092ed
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	COL4A1 MYLK POSTN PRKG1 C7	8.02e-05	194	101	5	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	nucseq-Mesenchymal-Myocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL4A1 MYLK POSTN PRKG1 NOTCH3	8.02e-05	194	101	5	2d66091097e106c7bee22e5281f50724700bdf8d
ToppCell	15-Airway-Mesenchymal-Pericyte\|Airway / Age, Tissue, Lineage and Cell class	COL4A1 MYL6 MYLK PRKG1 NOTCH3	8.02e-05	194	101	5	5c1218d239c88082496924653ed2a092dc44a906
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL4A1 MYLK NCAPG PRKG1 NOTCH3	8.02e-05	194	101	5	78dcb9d48259afabe73b41c5508a73a8d62339a4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 MYLK POSTN PRKG1 C7	8.21e-05	195	101	5	49c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 MYLK RGS2 POSTN NOTCH3	8.21e-05	195	101	5	2eed0332e338d6f0dbcb399d9d36c4611d491b0a
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 EPHX1 POSTN MAPRE2 NOTCH3	8.21e-05	195	101	5	4a5d2f62aad5817d077177bf8b4ff0e46d3b8d97
ToppCell	myeloid-CD14+_Monocyte\|myeloid / Lineage and Cell class	HPSE RGS2 SLC11A1 AP1S2 ATP2B1	8.21e-05	195	101	5	60fab0c24c827567fb42bbd7eb165bf45178c198
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 MYLK POSTN PRKG1 C7	8.21e-05	195	101	5	dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYL6 MYLK POSTN PRKG1 NOTCH3	8.21e-05	195	101	5	c51b1bee79e77aa2ac444a4883ef533c0095eaad
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 EPHX1 POSTN MAPRE2 NOTCH3	8.21e-05	195	101	5	7a32a8535c29b819dacba901d0658280a2631c94
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYL6 MYLK POSTN C4B NOTCH3	8.21e-05	195	101	5	43d372373367b71243c6ea958aedccde4478618f
ToppCell	ASK452\|World / Donor, Lineage and Cell class of Lung cells from Dropseq	COL4A1 RGS2 POSTN C7 ATP2B1	8.21e-05	195	101	5	7efd9d3a3f5e7dfe9698a4143ce4a0f9bf3a862c
ToppCell	COPD-Stromal-Myofibroblast\|COPD / Disease state, Lineage and Cell class	COL4A1 MYLK POSTN PRKG1 C7	8.41e-05	196	101	5	af206bb5bbb8b604a6212acd79878bcc3d326cec
ToppCell	11.5-Distal-Mesenchymal-Airway_Smooth_Muscle\|Distal / Age, Tissue, Lineage and Cell class	COL4A1 MYL6 MYLK POSTN RBM38	8.41e-05	196	101	5	05530fe7a5681c2f39b95016cd22ef99d6ac0430
ToppCell	IPF-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	COL4A1 MYLK POSTN PRKG1 C7	8.41e-05	196	101	5	7fc9894ceb79dab9f0495acc84e2d6d0d1c69bb7
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 EPHX1 RGS2 POSTN NOTCH3	8.41e-05	196	101	5	acbb493dbb49a33f20cf11106363f7ed51209706
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL4A1 PPEF1 PRKG1 C7 NOTCH3	8.41e-05	196	101	5	7acd782a587b7d331517f60daa8b5c2177bedfc7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 MYLK PRKG1 C7 NOTCH3	8.41e-05	196	101	5	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HPSE RGS2 SLC11A1 AP1S2 ATP2B1	8.41e-05	196	101	5	555c9e443fe3b9893cb320b78d84002e1f8c1701
ToppCell	IPF-Stromal-Myofibroblast\|IPF / Disease state, Lineage and Cell class	COL4A1 MYLK POSTN PRKG1 C7	8.41e-05	196	101	5	2d0a48e49b3b37bb66e33e74c52915911e1f8a74
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 MYLK PRKG1 C7 NOTCH3	8.41e-05	196	101	5	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZMYND15 EPHX1 PSEN2 ARRB1 WNK4	8.41e-05	196	101	5	e386526332138e636aef2542c11316347a45689c
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HPSE RGS2 SLC11A1 AP1S2 ATP2B1	8.41e-05	196	101	5	a1b21f4667c05e837a1229cc5934db805ad562c5
ToppCell	metastatic_Lymph_Node-Fibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	COL4A1 MYLK POSTN PRKG1 C7	8.41e-05	196	101	5	275e153347caf94edc0c50021bbab49c8696fecb
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PPEF1 POSTN CAMKV AP1S2 MAPRE2	8.62e-05	197	101	5	1378bf90a4b80b8166ef352c282ce51b114ba693
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	KCNK15 C4A C4B WNK4 ALOX15	8.62e-05	197	101	5	88a86286b9c3ea3b076d7464faec42d0392ee7f8
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic-Mesothelia\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	KCNK15 C4A C4B WNK4 ALOX15	8.62e-05	197	101	5	2773d2eb5f232a7e49da116efffcb6bf5eb90810
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	MYLK POSTN PRKG1 C7 CFAP69	8.62e-05	197	101	5	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	343B-Myeloid-Dendritic\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	NASP SGO1 RGS2 NCAPG AP1S2	8.62e-05	197	101	5	b340d6f041231e5c69140895aaa1e8d28bafb998
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HPSE RGS2 SLC11A1 AP1S2 ATP2B1	8.62e-05	197	101	5	f431f11196dc4332933b5d71c7c7408d54c2dedc
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHX1 CLSTN3 C7 ALPK2 NOTCH3	8.62e-05	197	101	5	5fbbc570a4e77c703f569a4f85ce2d8af67d6297
ToppCell	356C-Fibroblasts-Fibroblast-K_(Pericytes)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	COL4A1 MYL6 MYLK PRKG1 NOTCH3	8.62e-05	197	101	5	71367bebc23d0e81f60f780d6b0ab3a1783ac014
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 MYLK RGS2 POSTN NOTCH3	8.62e-05	197	101	5	e132f4b9deef6a565262c0aa0863cafe28f248e6
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	COL4A1 MYLK POSTN PRKG1 C7	8.62e-05	197	101	5	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	356C-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	COL4A1 MYL6 MYLK PRKG1 NOTCH3	8.62e-05	197	101	5	0f9836554ace3f9d155ebafdd719aa26466ca44e
ToppCell	PBMC\|World / Compartment, Disease Groups and Clusters	SRSF6 RGS2 EIF4B MYO1F AP1S2	8.83e-05	198	101	5	84f5b43dad0c57556171dbc0b799735654582ecf
Disease	Alzheimer's disease 3 (implicated_via_orthology)	PSEN1 PSEN2	1.14e-05	2	100	2	DOID:0110042 (implicated_via_orthology)
Disease	Dementia	COL4A1 PSEN2 NOTCH3	2.48e-05	17	100	3	C0497327
Disease	Familial schizencephaly	COL4A1 SHH	6.79e-05	4	100	2	C2931870
Disease	Schizencephaly	COL4A1 SHH	6.79e-05	4	100	2	C0266484
Disease	Non-alcoholic Fatty Liver Disease	LAMA1 PEMT PNPLA3 KLB	9.59e-05	70	100	4	C0400966
Disease	Nonalcoholic Steatohepatitis	LAMA1 PEMT PNPLA3 KLB	9.59e-05	70	100	4	C3241937
Disease	Ovarian Mucinous Adenocarcinoma	MYLK RPS6KC1 WNK4	1.58e-04	31	100	3	C1335167
Disease	early-onset Parkinson's disease (implicated_via_orthology)	PSEN1 PSEN2	1.69e-04	6	100	2	DOID:0060894 (implicated_via_orthology)
Disease	Asphyxia Neonatorum	PSEN1 PSEN2	1.69e-04	6	100	2	C0004045
Disease	Complement deficiency disease	C4A C4B C7	1.91e-04	33	100	3	C0272242
Disease	Early-onset autosomal dominant Alzheimer disease	PSEN1 PSEN2	2.36e-04	7	100	2	cv:CN043596
Disease	autism spectrum disorder (is_marker_for)	SHH EIF4B	2.36e-04	7	100	2	DOID:0060041 (is_marker_for)
Disease	cytochrome c oxidase assembly factor 3 homolog, mitochondrial measurement	PIKFYVE C7	3.14e-04	8	100	2	EFO_0801513
Disease	Alzheimer disease	PSEN1 PSEN2	3.14e-04	8	100	2	cv:C0002395
Disease	cytochrome c oxidase subunit 4 isoform 2, mitochondrial measurement	PIKFYVE C7	4.03e-04	9	100	2	EFO_0801514
Disease	RNA-binding protein 24 measurement	PIKFYVE C7	4.03e-04	9	100	2	EFO_0802030
Disease	DNA-directed RNA polymerases I and III subunit RPAC1 measurement	PIKFYVE C7	5.03e-04	10	100	2	EFO_0801535
Disease	Familial thoracic aortic aneurysm and aortic dissection	MYLK PRKG1	5.03e-04	10	100	2	cv:C4707243
Disease	Cardiomyopathy, Dilated	PSEN1 PSEN2 RENBP	5.85e-04	48	100	3	C0007193
Disease	thoracic aortic aneurysm (is_implicated_in)	MYLK PRKG1	6.13e-04	11	100	2	DOID:14004 (is_implicated_in)
Disease	guanylate-binding protein 6 measurement	PIKFYVE C7	6.13e-04	11	100	2	EFO_0801662
Disease	Cardiomyopathy, Familial Idiopathic	PSEN1 PSEN2 RENBP	6.59e-04	50	100	3	C1449563
Disease	Centriacinar Emphysema	EPHX1 MMP12	7.34e-04	12	100	2	C0221227
Disease	Panacinar Emphysema	EPHX1 MMP12	7.34e-04	12	100	2	C0264393
Disease	Parkinson Disease, Secondary Vascular	SHH RGS2	7.34e-04	12	100	2	C0751414
Disease	Atherosclerotic Parkinsonism	SHH RGS2	7.34e-04	12	100	2	C0751415
Disease	Secondary Parkinson Disease	SHH RGS2	7.34e-04	12	100	2	C0030569
Disease	Focal Emphysema	EPHX1 MMP12	7.34e-04	12	100	2	C2350878
Disease	Familial thoracic aortic aneurysm and aortic dissection	COL4A1 MYLK PRKG1	7.82e-04	53	100	3	C4707243
Disease	Metastatic melanoma	WNK4 ALPK2 EPHA8	8.26e-04	54	100	3	C0278883
Disease	Migraine Disorders	COL4A1 NOTCH3	8.66e-04	13	100	2	C0149931
Disease	Impaired cognition	COL4A1 NOTCH3	1.01e-03	14	100	2	C0338656
Disease	anemia (is_implicated_in)	EPHX1 SLC11A2	1.01e-03	14	100	2	DOID:2355 (is_implicated_in)
Disease	Cerebrovascular accident	COL4A1 MMP12 NOTCH3	1.24e-03	62	100	3	C0038454
Disease	systemic lupus erythematosus (is_implicated_in)	SLC11A1 C4A C4B	1.24e-03	62	100	3	DOID:9074 (is_implicated_in)
Disease	Pulmonary Emphysema	EPHX1 MMP12	1.50e-03	17	100	2	C0034067
Disease	Eye Abnormalities	COL4A1 SHH	1.50e-03	17	100	2	C0015393
Disease	major depressive disorder (is_marker_for)	ARRB1 EIF4B	1.50e-03	17	100	2	DOID:1470 (is_marker_for)
Disease	C-X-C motif chemokine 16 measurement	ZMYND15 ALOX15	1.68e-03	18	100	2	EFO_0010911
Disease	brain age measurement	SHH PRKG1	2.08e-03	20	100	2	EFO_0010602
Disease	Infiltrating duct carcinoma of female breast	RPS6KC1 EPHA8	2.29e-03	21	100	2	C3165106
Disease	Acute Lung Injury	EPHX1 MYLK	2.51e-03	22	100	2	C0242488
Disease	Colorectal Carcinoma	CLSTN3 SLC11A2 SRSF6 LAMA1 POSTN KMT2C NCAPG UQCRC2	2.69e-03	702	100	8	C0009402
Disease	Rheumatoid Arthritis	IL23A SLC11A1 MMP10 MMP12	2.95e-03	174	100	4	C0003873

Protein segments in the cluster

Peptide	Gene	Start	Entry
FALDKDAPLRYAGEI	CLSTN3	51	Q9BQT9
YVRFGLLDEDGKKTF	C4B	281	P0C0L5
KKLDFFGRGDTYVSL	ADGRG4	31	Q8IZF6
KEDFLHDSYFGGRLR	ALPK2	1901	Q86TB3
LAEYLFDKLTLGGRV	FTHL17	166	Q9BXU8
RLDGYRGDFETFIKS	ABCF3	401	Q9NUQ8
LFLKAQALLFGGYRD	DENND1C	331	Q8IV53
FRYGREDLDVLGLTF	ARRB1	61	P49407
LLFAGEKFFDIDSGR	ATP2B1	946	P20020
GEFYFDLRLKGDKGD	COL4A1	531	P02462
YDFLLKFLLVGDSDV	RAB40B	11	Q12829
TDASLRKYFEGFGDI	RBM38	46	Q9H0Z9
IGLFIKAGSRYEDFS	UQCRC2	61	P22695
LFGERYLEKFYGLEI	MMP12	31	P39900
SRLGFTIFSLYKEDG	KIR2DL5A	51	Q8N109
GGARYSLSRELLKDF	KCNG3	16	Q8TAE7
SGFQDLKLREFYCEG	LRRC69	216	Q6ZNQ3
FEKAYFILDEFLLGG	AP1S2	106	P56377
ALVRDVAGEFYKFGL	CYP27B1	181	O15528
DAISTLRGEYLFFKD	MMP10	296	P09238
LDAAKAGGEFLLRYA	RENBP	91	P51606
SIYSLKRLDAFIDGF	KLHL36	156	Q8N4N3
SDFYDIEERLGSGKF	MYLK	1461	Q15746
AYLQEAFFGKDLLDT	KMT2C	1361	Q8NEZ4
AASDFYRKGVDLLLE	RPS6KC1	261	Q96S38
KFGFSAEDYRELERL	KCNK15	51	Q9H427
ILDHRGYAKLVDFGF	PRKG1	491	Q13976
FLEFEFRPDGKLRYA	MAGOH	21	P61326
KAYVLLGDDSFLERF	EDEM3	301	Q9BZQ6
DYLRKLFTDLFDRSG	CSNK1G2	306	P78368
LFGLRFSYEDKEFQA	CYP2S1	186	Q96SQ9
SRLGFTIFSLYKEDG	KIR2DL5B	51	Q8NHK3
FQLFDRTGDGKILYS	MYL6	16	P60660
LLYGYREGFDKIDLT	NUDT6	271	P53370
GYLDAFRFLEEKGIC	PNPLA3	241	Q9NST1
LFLAAREGSYEAAKL	NOTCH3	1976	Q9UM47
DLADRGLLGVKSSFY	ALOX15	446	P16050
FLDNYGLRKLEAFFG	SLC11A1	186	P49279
ADTFVFLFLDKYGLR	SLC11A2	191	P49281
FGLEELYGLALRFFK	ACBD3	81	Q9H3P7
ITDAGIGYLFSFRKL	LRRC42	246	Q9Y546
DYNGERTLDGFKKFL	P4HB	456	P07237
EKLFGFLLEYVGDLA	NOP14	471	P78316
YLRFGGTKTDFLIFD	HPSE	91	Q9Y251
EAFFFYGKSLLELAR	NASP	86	P49321
TFLGDYFGILKEARV	PEMT	116	Q9UBM1
GREGKLDVYLFLFSD	PLEKHG6	421	Q3KR16
FYGKNDLTLGIFLER	PIKFYVE	1246	Q9Y2I7
RLDAILSLFAFLGGY	ESPL1	356	Q14674
EFRYLEDGGLERKFS	EPHX1	336	P07099
FDGTEVLKGDEFKRY	IFT81	386	Q8WYA0
LFRKILAGDYEFDSP	CAMKV	236	Q8NCB2
IGSKRYLDFEDLGRL	CYP46A1	336	Q9Y6A2
RYEKLDFLGEGQFAT	CDK7	11	P50613
LGLARYDFSGLKTFL	CERK	306	Q8TCT0
LSKRGFYLAFQDIGA	EPHA8	176	P29322
RKVFSGDGKDFYRLS	C7	166	P10643
GLIFYEKLLGSDIFT	IL23A	96	Q9NPF7
LALEGVEKERDFYFG	MAPRE2	256	Q15555
KDDASYLRLSLGEFF	CEP192	571	Q8TEP8
YIFLEKDLSALDFIG	KLB	131	Q86Z14
LGVGYFAFARDKELR	CCDC174	246	Q6PII3
FRKLASGFGEDVDGY	EXOC3	641	O60645
LIGRKELFAAFGFYD	ZMPSTE24	366	O75844
SEDYFLEKEGIFLLL	CFAP69	601	A5D8W1
EYLKDSNLLFFGGLL	SLC13A2	81	Q13183
YGENGRLSFFGLEKL	SLC39A10	71	Q9ULF5
YALFLRFESVGSKDG	CFAP47	366	Q6ZTR5
YVRFGLLDEDGKKTF	C4A	281	P0C0L4
LKGFGYAEFEDLDSL	EIF4B	136	P23588
GDLHGKLDDLFLIFY	PPEF1	171	O14829
SLEKGFLYRALGFTL	MROH2A	681	A6NES4
GKVDEIFGQLRDFYF	GAR1	111	Q9NY12
ELLASKYGLAAFRAF	RGS2	86	P41220
GRLLYSDFLTFLDRD	SHH	231	Q15465
LFLKEGACDELFSYL	PRAME	181	P78395
ERGVKLGLGDFIFYS	PSEN1	376	P49768
YLLGGEENDLDFFTK	KBTBD4	381	Q9NVX7
LFRDRFDGYIFLDSK	UPF3A	126	Q9H1J1
GSYGTKDFLSIELFR	LAMA1	2346	P25391
STFFRDLGDKGLISY	MICU2	146	Q8IYU8
LAGKSFEFERVGFLD	SGO1	216	Q5FBB7
LLALKLYEEAGDVFF	SH3TC2	1081	Q8TF17
GYEKALEFATLAARL	SH3TC2	1141	Q8TF17
FFSGYGRLLEVDLKN	SRSF6	21	Q13247
EFKRGSGEYLSLAFK	SLFNL1	226	Q499Z3
EDGGLLNYLFTFLLK	NCAPG	91	Q9BPX3
KFLSLFGGIYENESR	CLCN2	221	P51788
LAAIKLGRYGEDLLF	CNOT2	431	Q9NZN8
LLGRGGFSEVYKAFD	TLK1	461	Q9UKI8
GLEQKLERDFYAGLF	ARHGAP40	321	Q5TG30
RLAVKAAFFGLLGYS	TRABD	331	Q9H4I3
VEEEYKLRKAIFFGG	TBC1D16	411	Q8TBP0
GFRFSLEGSRLTYEK	SCN2A	536	Q99250
EERGVKLGLGDFIFY	PSEN2	356	P49810
LSLGAGFDSLYFRLK	LCMT2	86	O60294
GFDSLYFRLKTAGRL	LCMT2	91	O60294
KLREEIEGKGSFTYF	POSTN	121	Q15063
FEDDSRGKYLELLGY	SEC31A	481	O94979
GYRDEFLDFTALLFG	ZMYND15	6	Q9H091
GRYLKFDIEIGRGSF	WNK4	171	Q96J92
EASIDFRFGKTYLKG	TYW1B	111	Q6NUM6
GLIEFSVGKFRYFEL	TM7SF3	31	Q9NS93
FLKSGDYVDREAIFL	VPS13D	4286	Q5THJ4
DALAKGLYARLFDFL	MYO1F	351	O00160