Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncarbohydrate binding

CRYBG2 UAP1 DCDC1 FBXO2 IGF2R ACAN ASGR2 C4A C4B

3.52e-053101049GO:0030246
DomainMed12

MED12L MED12

2.95e-0521022PF09497
DomainMediator_Med12_catenin-bd

MED12L MED12

2.95e-0521022IPR021989
DomainMed12-PQL

MED12L MED12

2.95e-0521022PF12144
DomainMed12-LCEWAV

MED12L MED12

2.95e-0521022PF12145
DomainMed12

MED12L MED12

2.95e-0521022SM01281
DomainMediator_Med12

MED12L MED12

2.95e-0521022IPR019035
DomainMediator_Med12_LCEWAV

MED12L MED12

2.95e-0521022IPR021990
DomainSRCR

PRSS12 LGALS3BP DMBT1

1.96e-04211023PF00530
DomainConA-like_dom

COL15A1 TRIM41 CNTNAP1 NBEA TRIM34 PTPRK SPSB2

1.99e-042191027IPR013320
DomainAnaphylatoxin_comp_syst

C4A C4B

2.92e-0451022IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

2.92e-0451022IPR001840
Domain-

PRSS12 LGALS3BP DMBT1

3.33e-042510233.10.250.10
DomainSR

PRSS12 LGALS3BP DMBT1

3.33e-04251023SM00202
DomainSRCR-like_dom

PRSS12 LGALS3BP DMBT1

3.75e-04261023IPR017448
DomainSRCR_1

PRSS12 LGALS3BP DMBT1

3.75e-04261023PS00420
DomainSRCR_2

PRSS12 LGALS3BP DMBT1

3.75e-04261023PS50287
DomainSRCR

PRSS12 LGALS3BP DMBT1

4.21e-04271023IPR001190
DomainANATO

C4A C4B

6.09e-0471022SM00104
DomainDUF3585

MICAL1 EHBP1L1

6.09e-0471022IPR022735
DomainANAPHYLATOXIN_2

C4A C4B

6.09e-0471022PS01178
DomainANAPHYLATOXIN_1

C4A C4B

6.09e-0471022PS01177
DomainDUF3585

MICAL1 EHBP1L1

6.09e-0471022PF12130
DomainANATO

C4A C4B

6.09e-0471022PF01821
DomainAnaphylatoxin/fibulin

C4A C4B

6.09e-0471022IPR000020
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

8.09e-0481022IPR019565
DomainThiol-ester_cl

C4A C4B

8.09e-0481022PF10569
DomainMacrogloblnA2_CS

C4A C4B

8.09e-0481022IPR019742
DomainA2M

C4A C4B

1.29e-03101022PF00207
DomainA2M_N_2

C4A C4B

1.29e-03101022IPR011625
DomainA2M_comp

C4A C4B

1.29e-03101022IPR011626
DomainA2M_recep

C4A C4B

1.29e-03101022PF07677
DomainA2M_comp

C4A C4B

1.29e-03101022PF07678
DomainA2M_N

C4A C4B

1.29e-03101022PF01835
DomainA2M_N

C4A C4B

1.29e-03101022IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

1.29e-03101022IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

1.29e-03101022PS00477
DomainA2M_N_2

C4A C4B

1.29e-03101022PF07703
DomainMacroglobln_a2

C4A C4B

1.29e-03101022IPR001599
DomainPLAC

ADAMTS19 ADAMTS17

2.57e-03141022PF08686
DomainC345C

C4A C4B

3.81e-03171022SM00643
Domainig

LILRA1 PTGFRN TYRO3 PTPRK IGHE

3.88e-031901025PF00047
DomainImmunoglobulin

LILRA1 PTGFRN TYRO3 PTPRK IGHE

3.88e-031901025IPR013151
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

4.27e-03181022IPR008930
DomainNTR

C4A C4B

4.75e-03191022PF01759
DomainNetrin_module_non-TIMP

C4A C4B

4.75e-03191022IPR018933
DomainPLAC

ADAMTS19 ADAMTS17

4.75e-03191022PS50900
DomainPLAC

ADAMTS19 ADAMTS17

4.75e-03191022IPR010909
DomainTSP_1

ADAMTS19 ADAMTS17 C8A

4.95e-03631023PF00090
DomainUBA-like

USP24 USP5 DCUN1D2

5.18e-03641023IPR009060
DomainTSP1

ADAMTS19 ADAMTS17 C8A

5.41e-03651023SM00209
DomainTSP1_rpt

ADAMTS19 ADAMTS17 C8A

5.41e-03651023IPR000884
DomainTSP1

ADAMTS19 ADAMTS17 C8A

5.41e-03651023PS50092
PathwayBIOCARTA_LECTIN_PATHWAY

C4A C4B C8A

5.01e-0513813M4732
PathwayBIOCARTA_CLASSIC_PATHWAY

C4A C4B C8A

7.91e-0515813M7146
PathwayWP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY

C4A C4B C8A

1.17e-0417813MM15944
PathwayBIOCARTA_COMP_PATHWAY

C4A C4B C8A

1.94e-0420813M917
PathwayWP_COMPLEMENT_ACTIVATION

C4A C4B C8A

2.60e-0422813M39502
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

MYO6 PRSS12 LCAT CUBN LGALS3BP EHD4 ASGR2 DMBT1 SOAT2

3.28e-04381819M48063
Pubmed

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

RELN IGF2R SVIL GPC5

5.72e-0639104419010793
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

8.86e-062104222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

8.86e-062104216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

8.86e-062104215998580
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

8.86e-062104219062096
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

8.86e-062104219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

8.86e-06210422459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

8.86e-062104217645767
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

8.86e-062104212207352
Pubmed

Microvesicles in active lupus nephritis show Toll-like receptor 9-dependent co-expression of galectin-3 binding protein and double-stranded DNA.

TLR9 LGALS3BP

8.86e-062104233354779
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

8.86e-062104227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

8.86e-062104222387014
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

8.86e-062104223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

8.86e-062104223918728
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

8.86e-06210423037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

8.86e-062104211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

8.86e-06210424216347
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

8.86e-06210426950384
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

8.86e-06210428660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

8.86e-06210428428773
Pubmed

METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism.

METTL3 FASN

8.86e-062104231405565
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

8.86e-062104224638111
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

8.86e-062104221345967
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

8.86e-06210422572548
Pubmed

The complement component C4 of mammals.

C4A C4B

8.86e-06210422302180
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

8.86e-062104222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

8.86e-062104218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

8.86e-062104229080553
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

8.86e-06210426589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

8.86e-062104225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

8.86e-062104217728371
Pubmed

Structure and organization of the C4 genes.

C4A C4B

8.86e-06210426149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

8.86e-06210426149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

8.86e-062104212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

8.86e-06210423542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

8.86e-06210422387317
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

8.86e-062104216908004
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

8.86e-06210427365238
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

8.86e-06210427391573
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

8.86e-062104217971360
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

8.86e-062104229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

8.86e-062104217971229
Pubmed

Epistasis between IGF2R and ADAMTS19 polymorphisms associates with premature ovarian failure.

ADAMTS19 IGF2R

8.86e-062104224014609
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

8.86e-06210426881182
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

8.86e-062104217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

8.86e-062104221880985
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

8.86e-06210426978711
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

8.86e-062104235898513
Pubmed

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

C4A C4B

8.86e-062104228873507
Pubmed

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.

C4A C4B

8.86e-0621042276882
Pubmed

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

C4A C4B

8.86e-06210426832377
Pubmed

Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.

C4A C4B

8.86e-06210423794341
Pubmed

Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner.

TLR9 LGALS3BP

8.86e-062104231681284
Pubmed

Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.

C4A C4B

8.86e-062104222785613
Pubmed

Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.

C4A C4B

8.86e-062104232691186
Pubmed

The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.

C4A C4B

8.86e-06210428390682
Pubmed

Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).

C4A C4B

8.86e-06210423902619
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

8.86e-06210427373044
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

8.86e-06210423696167
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

8.86e-06210421357031
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

8.86e-062104216098595
Pubmed

Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.

C4A C4B

8.86e-062104215787745
Pubmed

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.

C4A C4B

8.86e-062104230026462
Pubmed

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.

C4A C4B

8.86e-06210426559257
Pubmed

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

C4A C4B

8.86e-062104234299197
Pubmed

Assessment of complement C4 gene copy number using the paralog ratio test.

C4A C4B

8.86e-062104220506482
Pubmed

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

C4A C4B

8.86e-062104212480675
Pubmed

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

C4A C4B

8.86e-062104226800705
Pubmed

Murine complement C4 is not required for experimental autoimmune encephalomyelitis.

C4A C4B

8.86e-062104215390104
Pubmed

Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.

C4A C4B

8.86e-06210421699796
Pubmed

Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

C4A C4B

8.86e-06210422997024
Pubmed

Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.

C4A C4B

8.86e-06210423624865
Pubmed

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.

C4A C4B

8.86e-062104221857912
Pubmed

Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.

C4A C4B

8.86e-06210426208559
Pubmed

The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.

C4A C4B

8.86e-06210424514997
Pubmed

The inheritance of susceptibility to the Gross leukemia virus in mice.

C4A C4B

8.86e-06210425919331
Pubmed

An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.

C4A C4B

8.86e-06210423167981
Pubmed

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.

C4A C4B

8.86e-06210427545960
Pubmed

Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.

C4A C4B

8.86e-062104230041577
Pubmed

Complete cDNA sequence of the fourth component of murine complement.

C4A C4B

8.86e-06210423862104
Pubmed

The BS variant of C4 protects against age-related loss of white matter microstructural integrity.

C4A C4B

8.86e-062104234358307
Pubmed

Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.

C4A C4B

8.86e-062104218360261
Pubmed

Ubiquitin specific peptidase 5 promotes ovarian cancer cell proliferation through deubiquitinating HDAC2.

USP5 HDAC2

8.86e-062104231727867
Pubmed

Schizophrenia risk from complex variation of complement component 4.

C4A C4B

8.86e-062104226814963
Pubmed

Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.

C4A C4B

8.86e-06210428132550
Pubmed

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

C4A C4B

8.86e-06210422395880
Pubmed

Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.

C4A C4B

8.86e-062104226814708
Pubmed

cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).

C4A C4B

8.86e-06210426192448
Pubmed

Complete primary structure of human C4a anaphylatoxin.

C4A C4B

8.86e-06210426167582
Pubmed

Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.

C4A C4B

8.86e-06210421438267
Pubmed

Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.

C4A C4B

8.86e-062104219150565
Pubmed

Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.

C4A C4B

8.86e-062104217506029
Pubmed

Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.

C4A C4B

8.86e-062104223715124
Pubmed

Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.

C4A C4B

8.86e-06210423464002
Pubmed

Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.

C4A C4B

8.86e-06210422993295
Pubmed

Identification of the site of sulfation of the fourth component of human complement.

C4A C4B

8.86e-06210423944109
Pubmed

Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.

C4A C4B

8.86e-062104233353966
Pubmed

Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).

C4A C4B

8.86e-06210423008092
Pubmed

The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.

C4A C4B

8.86e-06210426609966
Pubmed

Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.

C4A C4B

8.86e-06210422900855
Cytoband17q25

CYGB LGALS3BP FASN

9.73e-0539104317q25
GeneFamilyComplement system|Sushi domain containing

C4A C4B C8A

4.26e-0436743492
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

5.84e-0497421234
GeneFamilyImmunoglobulin like domain containing

PTGFRN TYRO3 PTPRK CEACAM16 IGSF9

1.17e-03193745594
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_RORB_CARTPT|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL26A1 PRSS12 FREM3 PTK2B PTPRK MED12L PDE7B

2.24e-0718010475e78b29fa1cbdcf502fee3577e5b45766b90d1dc
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_P2ry12|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PRSS12 LGALS3BP PROM2 SVIL SCN10A

2.38e-069110453f56358ff0dacdf6b8fc22cea64082231bceb851
ToppCellwk_15-18-Mesenchymal-Fibroblast-Mesenchymal_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

RELN COL26A1 NBEA ADAMTS17 KCNN3 IGSF9

3.29e-061731046b43817a6b1ed8d6b5366702343be4311c0d52d83
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL26A1 FREM3 KCNH3 TYRO3 PTK2B PTPRK

3.63e-061761046212e643c50c68462d4b016428ab30eeb7868ef40
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCDC1 COL26A1 KCNH3 TYRO3 PTK2B PDE7B

3.63e-061761046c7be4eaa5eb76ad9389fb9d15ad0934e88d267d1
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL26A1 FREM3 PTK2B PTPRK MED12L PDE7B

3.88e-061781046ccea3c8908d72f5fecd151a133048c8e9758304c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCDC1 COL26A1 TYRO3 PTK2B KCNN3 PDE7B

4.55e-0618310461645d4a55cd8c22d6eb47fc5c6b1e576c454f111
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCDC1 COL26A1 FREM3 PTK2B KCNN3 PDE7B

4.69e-06184104634e316ad8e7b8667cd8ad61397281802a252744f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

USP24 CLCNKA ADAMTS17 MED12L KCNN3 GPC5

5.31e-061881046bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellCV-Healthy-1|Healthy / Virus stimulation, Condition and Cluster

LGALS3BP EHD4 CACNA2D4 FGFBP2 OASL HERC5

5.99e-0619210462a2052b44e8f679ef484f03ba4fb37b0ec841b88
ToppCell11.5-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

RELN COL15A1 FBXO2 ACAN FGFBP2 RFLNA

6.17e-061931046d4779d92a4dd4b8b656383e6f4fce76d3bd70931
ToppCell18-Distal-Mesenchymal-Cartilage|Distal / Age, Tissue, Lineage and Cell class

RELN COL15A1 FBXO2 ACAN FGFBP2 RFLNA

6.17e-06193104652f3d1bb8d8ca91ba12439d46392f377928ff8f8
ToppCellTracheal-10x5prime-Stromal-Schwann-Schwann_Myelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SOX10 MICAL1 RELN MCF2L2 CUBN FGFBP2

7.35e-0619910462b567b6fd8addf059bbf2b72c55a7647aefdc595
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3---L2-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL26A1 FREM3 PTK2B MED12L KCNN3 PDE7B

7.56e-0620010469c89e91bb630cc306a820927a36ea6fb3d13e9d7
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3-|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL26A1 FREM3 PTK2B MED12L KCNN3 PDE7B

7.56e-0620010468821574d17b55dfea3ca0204e6b4c0ca6b19588a
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL26A1 FREM3 PTK2B MED12L KCNN3 PDE7B

7.56e-0620010460f23e72649a274043bf23e0952a9b5707c516acf
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3--|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL26A1 FREM3 PTK2B MED12L KCNN3 PDE7B

7.56e-06200104696b1d2e70fbbba744fd4356a70efcf356aca9abc
ToppCellBronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

POU6F1 CUBN ACAN FGFBP2 C4A PDE7B

7.56e-06200104629054cf55e88e1ac81a562d8dd9af9b7c749321d
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL26A1 FREM3 PTK2B MED12L KCNN3 PDE7B

7.56e-062001046ad6f1d4d7f5d7bab2ba2e4fff58c535290065c0e
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-3|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

LILRA1 PELI3 KCNH3 EHBP1L1 ASGR2

1.70e-0513610454f5e0b6c7d6e3e922af4daa7c3eb56490455c1df
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 PELI3 CUBN ACAN C4B

1.82e-051381045c1a46fbf1beffa12c3d1b78361e0613e2e9e2d13
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 PELI3 CUBN ACAN C4B

2.09e-05142104567d4ff3483ae34f77c3325aa0fbd3462ca19ade4
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 TLR9 PTK2B ASGR2 C4A

2.55e-0514810457c7c87b57aa16f8b91698489df39ace5a3a53df8
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 PELI3 CUBN ACAN C4B

2.72e-051501045afd651c654e715414eff64cf3a37378d057a56a2
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Hsd11b1_Endou|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COL15A1 COL26A1 PTGFRN PTPRK IGSF9

3.48e-051581045c8af8964a140acb2987e3b4906d72c546108d229
ToppCelldroplet-Lung-30m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l32|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN MMEL1 KDM8 SOAT2

3.54e-0579104411e92ae55dae24b6f73dd5a52e1c3c4e579ddf7b
ToppCell3'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK2 LILRA1 ARPC1B DARS2 CACNA2D4

3.81e-0516110453a5f2877e3b29463a3a6da05009b0ab8747b4c47
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL26A1 PRSS12 PTK2B PTPRK PDE7B

4.80e-051691045319cba07263bf41fcbcbfecd117f91b729394241
ToppCellClub-club-3|World / Class top

TLR9 FBXO2 CAPN13 TYRO3 DMBT1

5.22e-05172104534fbb82a2ec77dd183cf26b38edeb7e936b707bc
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PRSS12 PTGFRN PTK2B PTPRK MED12L

5.36e-0517310459a2d42f8d9cb834856522661d524abb91c4637c5
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Lymphocytic-B_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 MIF4GD CXCR5 PTK2B SLC22A1

5.36e-051731045a693772987f1baee533dd0bd285a3c7b5619a73b
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL26A1 FREM3 PTK2B PTPRK KCNN3

5.51e-0517410459cc7251661ea2b1565eef1dfb8cf6dec3ade13d4
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN KCNH3 IGHE GPC5 DNAH11

5.51e-05174104516204ff504b7b382b4d90ca35003ad5336020e07
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|356C / Donor, Lineage, Cell class and subclass (all cells)

CPB1 CAPN13 PROM2 IGSF9 C4B

5.66e-051751045af9c5104c86231cfdb93a0f7d7032379efaa009e
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|356C / Donor, Lineage, Cell class and subclass (all cells)

CPB1 CAPN13 PROM2 IGSF9 C4B

5.66e-0517510454bfae78ac3a2cb9404382aae96d291504a9cfa14
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP24 CLCNKA PROM2 ADAMTS17 GPC5

5.98e-051771045dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL26A1 KCNH3 TYRO3 PTK2B PDE7B

5.98e-0517710458b003ed7887479c3a010ef37dd981b748256bda7
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYGB KCNH3 PTK2B CEACAM16 IGSF9

6.14e-051781045a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK2 TMC6 LGALS3BP SVIL OASL

6.14e-0517810450b398656f26c4061b11ccf98908d0e2e1367585a
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYGB KCNH3 PTK2B CEACAM16 IGSF9

6.14e-0517810451bddbc083c36657bd6910f7466126ab325e88176
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PELI3 CYGB PHETA2 C4B SPSB2

6.47e-051801045e9785ac2806103f725f5a5208495826354ec6e22
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

MYO6 STXBP1 PTPRK SVIL GPC5

6.64e-051811045c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-chondrocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

COL15A1 FBXO2 ACAN FGFBP2 RFLNA

6.82e-051821045ed487f3a774812caa2903a646b60c86edcc1e65e
ToppCellEpithelial-lung_goblet_cell|World / Lineage, Cell type, age group and donor

UAP1 CRACR2A NBEA CAPN13 PROM2

7.00e-051831045940cbe298e9c53b5622af09264586ed823d3141f
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

MYO6 FASN PTPRK GPC5 DMBT1

7.18e-051841045369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellT_cells-Resident_memory_CD8+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

CRYBG2 CRACR2A FBXO2 ADAMTS17 SOAT2

7.18e-051841045e04cabff33a8e36967622ec3e5b37b89afa7e148
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL15A1 FBXO2 ACAN FGFBP2 RFLNA

7.37e-0518510458ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

MYO6 PRSS12 CAPN13 PTPRK GPC5

7.37e-051851045cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL15A1 FBXO2 ACAN FGFBP2 RFLNA

7.37e-051851045b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCellP28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FAM110D CYGB EHD4 PTK2B EHBP1L1

7.56e-051861045153c8b2fd8a6e2141ca97c626f82e5f081f3180a
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN CARMIL2 CNTNAP1 STXBP1 DNAH11

7.75e-0518710451b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FAM110D CYGB ARPC1B EHD4 PTK2B

7.95e-0518810455eb107122064f0a99dfd445cc87d3766f7257216
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

MYO6 FASN PTPRK GPC5 DNAH11

7.95e-051881045c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

USP24 CLCNKA ADAMTS17 KCNN3 GPC5

7.95e-051881045eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCellMesenchymal-chondrocyte|World / Lineage, Cell type, age group and donor

COL15A1 FBXO2 ACAN FGFBP2 RFLNA

7.95e-0518810457b1e3f8a941eaa68e89c562129a92314642eec66
ToppCelldroplet-Heart-HEART-1m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 RELN FBXO2 RFLNA DNAH11

8.15e-051891045a618a1ddf5097a010c6c2c7341f3a0bd46a29c02
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP24 ADAMTS17 MED12L KCNN3 GPC5

8.15e-051891045977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCelldroplet-Heart-HEART-1m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 RELN FBXO2 RFLNA DNAH11

8.15e-0518910454e61f9cd1c06bddb47ebf98affc0f97770e26e8c
ToppCellAdult|World / Lineage, Cell type, age group and donor

DOCK2 TMC6 PTK2B FASN DMBT1

8.15e-0518910455cd285bfad973125d46d704fec18b21266a63379
ToppCelldroplet-Heart-nan-18m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 RELN CRACR2A PRSS12 RGS11

8.15e-0518910450493f7b79127c207fd7ade778ef4810500495d7e
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CYGB ARPC1B EHD4 PTK2B EHBP1L1

8.35e-051901045d072bb285bd34d518b958e7c9ad44739c60b359c
ToppCellIPF-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

MYO6 MCF2L2 LGALS3BP SVIL OASL

8.35e-0519010452592765016f291565697265800a232b2edef3792
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP24 ADAMTS17 MED12L KCNN3 GPC5

8.35e-051901045e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

COL15A1 FBXO2 ACAN FGFBP2 RFLNA

8.56e-051911045273c4a757292a9301de0eaeacdec91c9866be229
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

COL15A1 FBXO2 ACAN FGFBP2 RFLNA

8.56e-051911045f9a46956778a8773d6656340ecf5d218376d79c2
ToppCellCOVID-19-Myeloid-TRAM2|Myeloid / Condition, Lineage and Cell class

MYO6 LGALS3BP SVIL OASL HERC5

9.21e-0519410454060a60c0271e7397b07993a1ef47b3291bba6e3
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

USP24 CLCNKA PROM2 ADAMTS17 MED12L

9.44e-051951045a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCell15-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

RELN COL15A1 FBXO2 ACAN RFLNA

9.44e-051951045414f60bc0f0d0ecb5137bcd617fae91f0c15038a
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN MYO6 NBEA RGS11 STXBP1

9.44e-0519510453e519cffa6144a62b06124642a14c9ff39b76554
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL26A1 PTK2B STXBP1 PTPRK PDE7B

9.44e-051951045787e95fb59c40bba784544b662fac37606ae1427
ToppCellMild-CD4+_T_activated|World / Disease group and Cell class

ARPC1B LGALS3BP EHD4 OASL HERC5

9.67e-051961045417b4fc2e4388f34c410576131b02936f93e46b6
ToppCellNS-moderate-d_07-13-Epithelial-Secretory|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

UAP1 LGALS3BP CAPN13 PTPRK PROM2

9.67e-05196104547930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCellFetal_29-31_weeks-Immune-monocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK2 LILRA1 PTK2B EHBP1L1 ASGR2

9.90e-05197104548a8169a4d33c6a68d66bcd936861c75cb4b60ef
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|lung / Disease (COVID-19 only), tissue and cell type

DOCK2 LILRA1 PTK2B EHBP1L1 ASGR2

9.90e-051971045a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCelldistal-Hematologic-Platelet/Megakaryocyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DCDC1 PRSS12 KCNH3 IGSF9 DNAH11

9.90e-051971045751ffb8792058384079ebfe94872b3525f1aea84
ToppCelldistal-Hematologic-Platelet/Megakaryocyte|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DCDC1 PRSS12 KCNH3 IGSF9 DNAH11

9.90e-051971045e28b1b154d9588dce07c123b36f7f01fa90a5fc1
ToppCelldroplet-Trachea-nan-3m-Mesenchymal-chondrocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UAP1 FBXO2 EHBP1L1 ACAN RFLNA

9.90e-0519710458786125b669d5d0b15e12df0ade6b319f09f7333
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK2 LILRA1 PTK2B EHBP1L1 ASGR2

1.01e-041981045ea34096bee852a7e996f097fa279381afa8f86ff
ToppCellBiopsy_Other_PF-Mesenchymal-Mesothelial_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

CPB1 FBXO2 IGSF9 C4A C4B

1.01e-04198104586736f01e61bf4961f060b24ee1f1f48340737dd
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 MYO6 FBXO2 TYRO3 FASN

1.01e-041981045731a90f7e68b19e387499d63e3979af78b503b0c
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

UAP1 FBXO2 EHBP1L1 ACAN RFLNA

1.01e-0419810453575620db5aeaeb0bdcd7a8ff65c43abd3fa13e4
ToppCellImmune-monocyte|World / Lineage, Cell type, age group and donor

DOCK2 LILRA1 PTK2B EHBP1L1 ASGR2

1.01e-041981045d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCell18-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

COL15A1 FBXO2 ACAN FGFBP2 RFLNA

1.04e-041991045f5d0aa4170367c080d3c2f01d9af3529762917fa
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-FILIP1L|Neuronal / cells hierarchy compared to all cells using T-Statistic

PRSS12 PTGFRN PTK2B PTPRK MED12L

1.06e-042001045f6af5ef02625aaae21e885e1ebd195e34731e53a
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-FILIP1L-|Neuronal / cells hierarchy compared to all cells using T-Statistic

PRSS12 PTGFRN PTK2B PTPRK MED12L

1.06e-04200104553f61e28c3ad6399f63c54e06120ecb5ebbf90d9
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-FILIP1L--L3-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

PRSS12 PTGFRN PTK2B PTPRK MED12L

1.06e-042001045c1f243ae929f7791e040437470033abf749b44cc
ToppCelldistal-3-Hematologic-Platelet/Megakaryocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DCDC1 PRSS12 KCNH3 IGSF9 DNAH11

1.06e-042001045f5f5a8b0e4d802d95dc42646dd5e7d7daaad72b4
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MYO6 FBXO2 KCNN3 GPC5 PDE7B

1.06e-042001045d0812817ef99608994193787a62d39adeb2070ca
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SOX10 ADAMTS19 CRACR2A DMBT1 TECPR1

1.06e-0420010457c2d499af60654b7b28f172ac2c914ad49fb74b4
ToppCellSevere-Myeloid-Macrophages-FCN1_high|Severe / Condition, Lineage, Cell class and cell subclass

LILRA1 APOBEC3B ASGR2 OASL HERC5

1.06e-042001045449623d6786e30d493f68156b3f1ee8caf9265a6
ToppCellmild-CD163+_Monocytes_(Sample_ID1_d7)|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LILRA1 APOBEC3B LGALS3BP OASL HERC5

1.06e-04200104599eb02f974ddc8d1882f4a5b34d4503d6ec0a5f5
ToppCellmild-CD163+_Monocytes_(Sample_ID1_d7)|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LILRA1 APOBEC3B LGALS3BP OASL HERC5

1.06e-04200104582126e25bfd8fba78dc1348fa5ad6a576289a139
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MYO6 FBXO2 KCNN3 GPC5 PDE7B

1.06e-042001045cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Col6a1_Fezf2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DCDC1 TLR9 OR52B2

1.48e-044410432aa44b57544d5264db5b265ae60f7460c5b2a217
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_ALM_Olfr111_Nxph1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PRSS12 LGALS3BP SVIL SCN10A

1.92e-041221044dba1c647172a11381efcb178a23808161908daa3
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MICAL1 C4A C4B GPC5

1.98e-041231044a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_ALM_Olfr111_Spon1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PRSS12 LGALS3BP SVIL SCN10A

2.24e-041271044cd69ba386796715e87674f8324d2acaad1d4d094
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_P2ry12|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PRSS12 LGALS3BP SVIL SCN10A

2.52e-04131104480630812f8894b9358d36dc2dd03fea7ee870502
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Crh|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PRSS12 LGALS3BP SCN10A KCNN3

2.91e-04136104444f03e4f55fb2c5f8b9397142c89f7194b009cc6
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial-Pericyte_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL15A1 PCNX3 CUBN GPC5

3.16e-0413910442fb51abb3ce88c21726c026d6365b2582e2e79f6
Drughalofuginone

CYGB PTGFRN LGALS3BP TYRO3 PTK2B C4B SMAD7

1.93e-061271047ctd:C010176
Diseasediverticulitis

NBEA CXCR5 SVIL PDE7B

8.46e-06371034EFO_1001460
DiseaseAutosomal dominant epilepsy with auditory features

MICAL1 RELN

3.61e-0531032cv:C1838062
DiseaseX-11261 measurement

IGF2R SLC22A1

3.61e-0531032EFO_0021221
DiseaseEPILEPSY, FAMILIAL TEMPORAL LOBE, 1

MICAL1 RELN

3.61e-0531032600512
DiseaseEpilepsy, Familial Temporal Lobe 1

MICAL1 RELN

3.61e-0531032C4551957
DiseaseEpilepsy, familial temporal lobe, 1

MICAL1 RELN

3.61e-0531032cv:C4551957
DiseaseX-24422 measurement

IGF2R SLC22A1

3.61e-0531032EFO_0800880
Diseasesystemic lupus erythematosus (is_implicated_in)

NAT2 TLR9 C4A C4B

6.69e-05621034DOID:9074 (is_implicated_in)
Diseasecation-independent mannose-6-phosphate receptor measurement

IGF2R SLC22A1

7.21e-0541032EFO_0008075
Diseasepolyunsaturated fatty acid measurement

NAT2 LCAT ASGR2 SLC22A1 DNAH11

9.87e-051311035EFO_0010733
Diseasewhole-brain volume

CUBN DNAH11

1.20e-0451032EFO_0005089
Diseasephospholipids:total lipids ratio

USP24 LCAT IGF2R SLC22A1 RFLNA SOAT2

1.49e-042271036EFO_0020946
DiseaseHirschsprung Disease

SOX10 RELN MED12

1.73e-04311033C0019569
DiseaseComplement deficiency disease

C4A C4B C8A

2.09e-04331033C0272242
Diseaseacisoga measurement

IGF2R SLC22A1

2.51e-0471032EFO_0800068
Diseasecholesteryl ester measurement

NAT2 LCAT IGF2R SLC22A1 OASL RFLNA

2.91e-042571036EFO_0010351
Diseaseargininate measurement

IGF2R SLC22A1

3.33e-0481032EFO_0800055
Diseasepimeloylcarnitine/3-methyladipoylcarnitine (C7-DC) measurement

IGF2R SLC22A1

3.33e-0481032EFO_0800494
DiseaseLiver carcinoma

NAT2 COL15A1 LCAT FASN IGF2R SLC22A1 KDM8 HERC5

4.10e-045071038C2239176
DiseaseX-11381 measurement

IGF2R SLC22A1

4.28e-0491032EFO_0021228
DiseaseSecondary Biliary Cholangitis

CYGB CXCR5 MMEL1

4.30e-04421033C0238065
DiseaseBiliary cirrhosis

CYGB CXCR5 MMEL1

4.30e-04421033C0023892
DiseaseBiliary Cirrhosis, Primary, 1

CYGB CXCR5 MMEL1

4.30e-04421033C4551595
Diseaseautistic disorder (is_implicated_in)

RELN MTR C4B

4.30e-04421033DOID:12849 (is_implicated_in)
DiseasePrimary biliary cirrhosis

CYGB CXCR5 MMEL1

5.99e-04471033C0008312
Diseaseomega-6 polyunsaturated fatty acid measurement

NAT2 IGF2R ASGR2 SLC22A1 DNAH11

6.50e-041971035EFO_0005680
Diseasenon-alcoholic fatty liver disease, cirrhosis of liver

CRACR2A EHBP1L1 SVIL

8.52e-04531033EFO_0001422, EFO_0003095
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

NAT2 IGF2R SLC22A1 RFLNA DNAH11

1.07e-032201035EFO_0004529, EFO_0008317
DiseaseReplication Error Phenotype

MSH6 HDAC2

1.23e-03151032C1721098
DiseaseMicrosatellite Instability

MSH6 HDAC2

1.23e-03151032C0920269
DiseaseMalignant neoplasm of breast

ADAMTS19 NAT2 MICAL1 MCF2L2 CUBN APOBEC3B CXCR5 MSH6 FASN MTR MED12

1.33e-03107410311C0006142
Diseasefree cholesterol measurement, low density lipoprotein cholesterol measurement

USP24 IGF2R SLC22A1 CEACAM16

1.38e-031371034EFO_0004611, EFO_0008591
Diseaseuridine diphosphate galactose measurement, uridine diphosphate glucose measurement

IGFN1 SVIL

1.59e-03171032EFO_0010543, EFO_0010544
DiseaseAntibody Deficiency Syndrome

C4A C8A

1.59e-03171032C0003257
Diseasehearing loss

MYO6 PTPRK ACAN

1.68e-03671033EFO_0004238
Diseasemelanoma

CUBN PTK2B FASN PTPRK HDAC2

1.81e-032481035C0025202
DiseasePhenyllactate (PLA) measurement

ADAMTS17 SLC38A7

1.99e-03191032EFO_0021662
DiseaseLupus Erythematosus, Systemic

PCNX3 C4A C4B

1.99e-03711033C0024141
Diseaselow density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

NAT2 LCAT IGF2R SOAT2

2.06e-031531034EFO_0004611, EFO_0020944
Diseasetemporal lobe epilepsy (is_marker_for)

RELN HDAC2

2.20e-03201032DOID:3328 (is_marker_for)
Diseaseend stage renal disease (implicated_via_orthology)

LCAT SOAT2

2.20e-03201032DOID:783 (implicated_via_orthology)
Diseasecitrate measurement

IGF2R SLC22A1 SLC38A7

2.69e-03791033EFO_0010114
DiseaseModerate albuminuria

CUBN TYRO3 EHBP1L1

2.79e-03801033HP_0012594
DiseaseImmunologic Deficiency Syndromes

C4A C8A

2.91e-03231032C0021051
DiseaseInvolutional paraphrenia

RELN FREM3

3.44e-03251032C1571983
DiseasePsychosis, Involutional

RELN FREM3

3.44e-03251032C1571984
DiseaseInvolutional Depression

RELN FREM3

3.44e-03251032C0011574

Protein segments in the cluster

PeptideGeneStartEntry
CNRRWVYDAIVTESG

ARL14EPL

126

P0DKL9
FVVYCDIRENRAWTV

CNTNAP1

611

P78357
GNLRYWLEEAECRDQ

EIF3B

291

P55884
WCYVGVVHRLRQAQR

CXCR5

236

P32302
QCETVYNGEWRELRY

C8A

176

P07357
EQESRVHYTVCIWRN

C4B

1461

P0C0L5
LCYEVERLDNGTWVL

APOBEC3B

216

Q9UH17
YRWVCEKRRNATGEV

ASGR2

296

P07307
EIQWDVDTIYHRQGC

CARMIL2

176

Q6F5E8
RIVTCGTDRNAYVWT

ARPC1B

66

O15143
IRREEAGAYQCEVWN

CEACAM16

191

Q2WEN9
QDDCWGYIERVRAAT

DNAH11

806

Q96DT5
LQLWDTAGQERYRCI

CRACR2A

596

Q9BSW2
AEQIQYRRGWEEIIS

CAPN13

256

Q6MZZ7
HDWIINRCGTEVRYV

HCCS

211

P53701
CPVGEQRRNLWTEAY

DAZ2

531

Q13117
RDQWTVYCRVIREKN

ADAMTS17

1051

Q8TE56
KGDRLVIACQEQTYW

RGS11

176

O94810
GDQWPVYCRVIREKN

ADAMTS19

1166

Q8TE59
CVWFYIGQREIESSE

KCNH3

376

Q9ULD8
VRWEYCVRAKRGQTD

KIAA0895L

366

Q68EN5
RDELVYVSCGELWIN

DCDC1

996

M0R2J8
PIYWSNVRCRGDEEN

PRSS12

231

P56730
WTELNTYVVCRQLGF

PRSS12

416

P56730
EYARYVLRTICQQEW

MED12L

1241

Q86YW9
RVEIFYRGQWGTVCD

LGALS3BP

36

Q08380
GVQTCEEVRKLFQWR

GPC5

26

P78333
WSLEYIQEIAGCRTV

KDM8

221

Q8N371
AGERTAIYCLTQNEW

DCUN1D2

21

Q6PH85
RQLDKVSQWCEAGIY

MCF2L2

431

Q86YR7
CRKAQVIDLQAEGYW

FBXO2

176

Q9UK22
EWIQYCASRRSQPVD

PCNX3

1556

Q9H6A9
WTVRVCERYHDQQDV

KCNN3

476

Q9UGI6
VARLACADITVNIWY

OR52B2

186

Q96RD2
QWSERVCEEFYRQGE

PDE7B

336

Q9NP56
NVIIWDTNRYTEDGC

DCAF10

276

Q5QP82
EVWLRVDCRNTDQTY

FGFBP2

56

Q9BYJ0
QSLLEWCQEVTTGYR

EHBP1L1

1041

Q8N3D4
LNYDREVVRVWFCNR

POU6F1

271

Q14863
YVLRSICQQEWVGER

MED12

1281

Q93074
QEELLRWCQEQTAGY

MICAL1

511

Q8TDZ2
QRISRGYDFCQVLQW

EHD4

166

Q9H223
VEEVRWRECVGYVNS

MMEL1

431

Q495T6
EKQRNRIGCRTIVYW

MSH6

956

P52701
RECLNLWGYERVDEI

METTL3

441

Q86U44
YEQCDAGWLRDQTVR

ACAN

521

P16112
ENLRVGEVYEACWAL

RELN

331

P78509
GYRWDIVAQRASQCL

OASL

316

Q15646
ELVGYRVTQIACGRW

HERC5

291

Q9UII4
NWECIYRITVRTGQL

CUBN

1071

O60494
IGDVVRIQETCGDWY

DOCK2

31

Q92608
VITFDCRNRGWYIQA

CACNA2D4

271

Q7Z3S7
FGAVVRWAEAECQRQ

BTBD1

241

Q9H0C5
WARLYANCEDVGVAI

CYGB

31

Q8WWM9
VASIRVVRGCWVLYE

CRYBG2

1016

Q8N1P7
VGTRDWIEGETYQCR

IGHE

286

P01854
CLTEERGIWYLDQIR

NAT2

151

P11245
VDCWIDNTRVVYNRS

LCAT

96

P04180
RRWTVADVRQGCQYE

IGFN1

801

Q86VF2
DQETYRCELIQGWNI

PTK2B

261

Q14289
IRNVARCWTYETAVA

HDAC2

306

Q92769
QEEAVLAAYWRGQCI

FASN

596

P49327
GVRLVDNYCEAWRTA

COL15A1

1331

P39059
KCVWEIEVNSGYRIN

DMBT1

1791

Q9UGM3
GQCRRYEVDWNQSAL

SLC22A1

86

O15245
CQWFVREAVRTYGRE

CPB1

186

P15086
GSETVVQRVYQSCRW

COL26A1

71

Q96A83
RRCVVLADGFYEWQR

HMCES

116

Q96FZ2
EQESRVHYTVCIWRN

C4A

1461

P0C0L4
EQLRARSLQGWVCYV

MIF4GD

91

A9UHW6
IAVDWESLGYNITRC

PTPRK

406

Q15262
HVNESARYVEVCVWR

FREM3

2021

P0C091
ARYVEVCVWRRGTDL

FREM3

2026

P0C091
DQGSYRCIVSEWIAE

PTGFRN

241

Q9P2B2
LQDGCEYVFIWRTVE

IGF2R

1201

P11717
VTLCGWIQYRRQNTF

DARS2

66

Q6PI48
VRCYWVDVTLNSVNL

TRIM34

296

Q9BYJ4
QREVWCVGTNGKRYQ

TRIM41

546

Q8WV44
CEEFWGSQERQRQLY

PRLHR

211

P49683
NVQSEWRLYCVRGEV

SVIL

1876

O95425
TLWCQGILETQEYRL

LILRA1

46

O75019
WREISVCGNVYTLRD

PELI3

256

Q8N2H9
RWRNSEIRCYVNGQL

NBEA

336

Q8NFP9
RRELWAYCGSEQLDV

MTR

1146

Q99707
ARVQDLIGLICWQYT

MAPKAP1

201

Q9BPZ7
NERTYQEVVWAVCGK

SLC38A7

111

Q9NVC3
RCAYEVTQANGKWEV

STXBP1

551

P61764
VERNARVIQWLYGCQ

FAM110D

246

Q8TAY7
GIQVSLYCQEWYARR

SOAT2

486

O75908
IGCVVRAHQWLYREI

CLCNKA

71

P51800
YGQEIVELRQCWQKR

PHETA2

231

Q6ICB4
IQLTREVDGVWVYNR

SMAD7

321

O15105
QEVQRYETYRWIVGC

PROM2

416

Q8N271
WVYNELRGQLEECRG

TLR9

886

Q9NR96
DVGWQVRKTCYRIVE

SCN10A

1136

Q9Y5Y9
ETIVAAPNCTWRNYR

RFLNA

136

Q6ZTI6
VWGIGCEDRAVYFRQ

TECPR1

346

Q7Z6L1
VWGQCQVRIRYLGER

SPSB2

206

Q99619
CIREAVSQVLSGYDW

SOX10

71

P56693
SACIRWKQDVEGAVY

POPDC2

16

Q9HBU9
EGLRVEDQGWYECRV

IGSF9

96

Q9P2J2
QRGIWSIHVYCVDNI

UAP1

241

Q16222
CQWLVEYFISSEGRE

USP24

2206

Q9UPU5
RRVGVLQGQCWEDFV

TMC6

531

Q7Z403
EGRWVIYNDQKVCAS

USP5

826

P45974
SVERSDAGRYWCQVE

TYRO3

106

Q06418
RQFEEIWERCGGIQY

MYO6

1256

Q9UM54
IWERCGGIQYLQNAI

MYO6

1261

Q9UM54