Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DYNC2H1 DNAH2 DYNC1H1	5.80e-05	18	85	3	GO:0008569
GeneOntologyMolecularFunction	guanine nucleotide transmembrane transporter activity	SLC17A9 SLC19A1	1.78e-04	5	85	2	GO:0001409
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DYNC2H1 DNAH2 DYNC1H1	2.26e-04	28	85	3	GO:0051959
GeneOntologyMolecularFunction	dynein intermediate chain binding	DYNC2H1 DNAH2 DYNC1H1	5.21e-04	37	85	3	GO:0045505
GeneOntologyCellularComponent	endoplasmic reticulum protein-containing complex	AMFR RPN2 EMC2 RNF139 RYR1	1.58e-04	125	85	5	GO:0140534
GeneOntologyCellularComponent	GARP complex	VPS52 VPS53	1.62e-04	5	85	2	GO:0000938
GeneOntologyCellularComponent	EARP complex	VPS52 VPS53	1.62e-04	5	85	2	GO:1990745
GeneOntologyCellularComponent	membrane protein complex	HIGD1A AMFR EFCAB9 RPN2 SGCG SYNE1 SCN8A TCIRG1 ABCC9 CALCRL OSMR EMC2 FLOT1 RNF139 RYR1 TTC19	3.13e-04	1498	85	16	GO:0098796
GeneOntologyCellularComponent	Derlin-1 retrotranslocation complex	AMFR RNF139	4.50e-04	8	85	2	GO:0036513
HumanPheno	Proximal lower limb amyotrophy	SYNE1 SPG11 DYNC1H1 RYR1	2.32e-05	20	45	4	HP:0008956
HumanPheno	Abnormality thigh musculature morphology	SYNE1 SPG11 DYNC1H1 RYR1	2.85e-05	21	45	4	HP:0001441
HumanPheno	Erlenmeyer flask deformity of the femurs	CSF1R TCIRG1 ABCC9	5.22e-05	9	45	3	HP:0004975
Domain	DHC_N1	DYNC2H1 DNAH2 DYNC1H1	5.01e-06	8	85	3	PF08385
Domain	Dynein_heavy_dom-1	DYNC2H1 DNAH2 DYNC1H1	5.01e-06	8	85	3	IPR013594
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH2 DYNC1H1	3.19e-05	14	85	3	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH2 DYNC1H1	3.19e-05	14	85	3	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH2 DYNC1H1	3.19e-05	14	85	3	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH2 DYNC1H1	3.19e-05	14	85	3	PF08393
Domain	MT	DYNC2H1 DNAH2 DYNC1H1	3.19e-05	14	85	3	PF12777
Domain	AAA_8	DYNC2H1 DNAH2 DYNC1H1	3.19e-05	14	85	3	PF12780
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DNAH2 DYNC1H1	3.19e-05	14	85	3	IPR011704
Domain	AAA_5	DYNC2H1 DNAH2 DYNC1H1	3.19e-05	14	85	3	PF07728
Domain	DHC_fam	DYNC2H1 DNAH2 DYNC1H1	3.98e-05	15	85	3	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DNAH2 DYNC1H1	3.98e-05	15	85	3	IPR004273
Domain	Dynein_heavy	DYNC2H1 DNAH2 DYNC1H1	3.98e-05	15	85	3	PF03028
Domain	SAM_1	EPHA6 SEC23IP BICC1	3.68e-03	68	85	3	PF00536
Domain	AAA+_ATPase	DYNC2H1 DNAH2 ABCC9 DYNC1H1	4.23e-03	144	85	4	IPR003593
Domain	AAA	DYNC2H1 DNAH2 ABCC9 DYNC1H1	4.23e-03	144	85	4	SM00382
Domain	Actinin_actin-bd_CS	SYNE1 MACF1	4.87e-03	23	85	2	IPR001589
Domain	DEP_dom	FMN2 DEPDC1	4.87e-03	23	85	2	IPR000591
Domain	Spectrin	SYNE1 MACF1	4.87e-03	23	85	2	PF00435
Domain	ACTININ_2	SYNE1 MACF1	4.87e-03	23	85	2	PS00020
Domain	ACTININ_1	SYNE1 MACF1	4.87e-03	23	85	2	PS00019
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TTLL12 AMFR VPS52 IPO9 RPN2 DYNC2H1 SLC19A1 SEC23IP DNAH2 EMC2 VPS53 BAG6 DYNC1H1 PGM3	7.73e-08	942	86	14	31073040
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TTLL12 GBF1 IPO9 NRDC RPN2 DYNC2H1 SYNE1 SEC23IP SUPT16H MRPS9 FASTKD2 SUZ12 EMC2 FLOT1 BAG6 DYNC1H1	3.74e-07	1425	86	16	30948266
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	AMFR VPS52 INTS14 IPO9 NRDC SEC23IP SUZ12 BAG6 DYNC1H1 PGM3	1.28e-06	560	86	10	35241646
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	HIGD1A AMPD1 ZNF536 IPO9 DYNC2H1 SEC23IP DNAH2 MRPS9 RYR1 TEFM	4.07e-06	638	86	10	31182584
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DYNC2H1 DNAH2 DYNC1H1	5.21e-06	14	86	3	9373155
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	UBR1 OMA1 ANK3 NRDC MRPS9 FASTKD2 VPS53 TTC19 TEFM	5.35e-06	515	86	9	31617661
Pubmed	Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6.	ANK3 SCN8A	6.04e-06	2	86	2	16775201
Pubmed	Human Plk4 phosphorylates Cdc25C.	CDC25C PLK4	6.04e-06	2	86	2	18239451
Pubmed	Inhibition of microtubules and dynein rescues human immunodeficiency virus type 1 from owl monkey TRIMCyp-mediated restriction in a cellular context-specific fashion.	DYNC2H1 DYNC1H1	6.04e-06	2	86	2	25502651
Pubmed	Genetic analysis of the cytoplasmic dynein subunit families.	DYNC2H1 DYNC1H1	6.04e-06	2	86	2	16440056
Pubmed	A new mouse model for autosomal recessive polycystic kidney disease.	ANK3 BICC1	6.04e-06	2	86	2	11944981
Pubmed	DEP Domain Containing 1 Promotes Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Colorectal Cancer by Enhancing Expression of Suppressor of Zest 12.	DEPDC1 SUZ12	6.04e-06	2	86	2	32343606
Pubmed	Preferential targeting of Nav1.6 voltage-gated Na+ Channels to the axon initial segment during development.	ANK3 SCN8A	6.04e-06	2	86	2	25874799
Pubmed	Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.	RASGRP1 ANK3 SYNE1	1.37e-05	19	86	3	18711365
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	TTLL12 ANK3 RPN2 DYNC2H1 SLC19A1 SYNE1 SUPT16H MRPS9 MACF1 SPG11 FASTKD2 EMC2 FLOT1 BAG6	1.63e-05	1487	86	14	33957083
Pubmed	The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation.	CSF1R EIF2AK1	1.81e-05	3	86	2	17932563
Pubmed	Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro.	DYNC2H1 DYNC1H1	1.81e-05	3	86	2	21723285
Pubmed	Cytoplasmic dynein promotes HIV-1 uncoating.	DYNC2H1 DYNC1H1	1.81e-05	3	86	2	25375884
Pubmed	Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.	DYNC2H1 DYNC1H1	1.81e-05	3	86	2	8666668
Pubmed	[Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier.	ANK3 SCN8A	1.81e-05	3	86	2	11807096
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF536 VPS52 INTS14 SUPT16H SCAPER FMN2 MACF1 SIGLEC1 SUZ12 OSMR VPS53 SLC40A1	1.93e-05	1116	86	12	31753913
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	VPS52 IPO9 EPHA6 SUPT16H SCAPER MRPS9 PARN SPG11 SUZ12 EIF2AK1 RNF139 BAG6 PGM3	2.24e-05	1327	86	13	32694731
Pubmed	Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.	RASGRP1 ORMDL3 IKZF4	3.23e-05	25	86	3	21829393
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	ADAMTS19 HIGD1A ZNF536 EPHA6 DSCAM ABCC9 ADGRV1 OSMR GTDC1 BICC1	3.33e-05	814	86	10	23251661
Pubmed	A tectorin-based matrix and planar cell polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane.	TECTB OTOG	3.61e-05	4	86	2	28935705
Pubmed	UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.	HIGD1A MRPS9 MACF1 SUZ12 PANX2	4.29e-05	155	86	5	34921745
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	AMFR RPN2 TCIRG1 EMC2 FLOT1 BAG6 DYNC1H1	5.48e-05	392	86	7	33144569
Pubmed	Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.	AMFR RNF139	6.01e-05	5	86	2	22143767
Pubmed	Characterization of the human GARP (Golgi associated retrograde protein) complex.	VPS52 VPS53	6.01e-05	5	86	2	15878329
Pubmed	Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.	VPS52 VPS53	6.01e-05	5	86	2	18367545
Pubmed	The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes.	VPS52 VPS53	6.01e-05	5	86	2	28658628
Pubmed	The Chaperone BAG6 Regulates Cellular Homeostasis between Autophagy and Apoptosis by Holding LC3B.	AMFR BAG6	6.01e-05	5	86	2	33241194
Pubmed	A neurogenomics approach to gene expression analysis in the developing brain.	NRDC NRXN2 SCAPER MACF1 IKZF4	6.65e-05	170	86	5	15582152
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	TTLL12 ORMDL3 GBF1 SUPT16H MRPS9 MACF1 FASTKD2 BAG6 DYNC1H1	6.71e-05	711	86	9	33022573
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	OMA1 VPS52 SYNE1 SEC23IP SUPT16H MRPS9 FASTKD2 EMC2 FLOT1 BAG6 DDX4 TTC19 TEFM	7.65e-05	1496	86	13	32877691
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	MACF1 DYNC1H1 DDX4	8.26e-05	34	86	3	25925205
Pubmed	A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.	OMA1 EIF2AK1	9.01e-05	6	86	2	32132706
Pubmed	Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.	OMA1 EIF2AK1	9.01e-05	6	86	2	32132707
Pubmed	Fine genetic map of mouse chromosome 10 around the polycystic kidney disease gene, jcpk, and ankyrin 3.	ANK3 BICC1	9.01e-05	6	86	2	8812475
Pubmed	TSSC1 is novel component of the endosomal retrieval machinery.	VPS52 VPS53	9.01e-05	6	86	2	27440922
Pubmed	Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.	AMFR RNF139	9.01e-05	6	86	2	23223569
Pubmed	Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.	SGCG SYNE1	9.01e-05	6	86	2	21738484
Pubmed	RNF41 interacts with the VPS52 subunit of the GARP and EARP complexes.	VPS52 VPS53	9.01e-05	6	86	2	28542518
Pubmed	A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.	AMFR BAG6	1.26e-04	7	86	2	23665563
Pubmed	ENU mutagenesis in mice identifies candidate genes for hypogonadism.	PLK4 BICC1	1.26e-04	7	86	2	22258617
Pubmed	Agrin has a pathological role in the progression of oral cancer.	AMFR IPO9 ANK3 SYNE1 SUPT16H	1.33e-04	197	86	5	29872149
Pubmed	Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.	HIGD1A AMFR IPO9	1.56e-04	42	86	3	32738194
Pubmed	Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex.	VPS52 VPS53	1.68e-04	8	86	2	20685960
Pubmed	PFGE mapping and RFLP analysis of the S/D region of the mouse H-2 complex.	BAG6 CFB	1.68e-04	8	86	2	1351875
Pubmed	A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart.	OMA1 SIGLEC1	1.68e-04	8	86	2	32937105
Pubmed	HIV-1 uncoating is facilitated by dynein and kinesin 1.	DYNC2H1 DYNC1H1	1.68e-04	8	86	2	25231297
Pubmed	Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions.	AMFR BAG6	1.68e-04	8	86	2	27387505
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	TTLL12 GBF1 IPO9 RPN2 SEC23IP SUPT16H BAG6 DYNC1H1	1.85e-04	638	86	8	33239621
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	IPO9 SYNE1 TCIRG1 OSMR RYR1	1.96e-04	214	86	5	22199357
Pubmed	EARP is a multisubunit tethering complex involved in endocytic recycling.	VPS52 VPS53	2.15e-04	9	86	2	25799061
Pubmed	Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.	VPS52 VPS53	2.15e-04	9	86	2	19620288
Pubmed	Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy.	ADAMTS19 CSF1R	2.15e-04	9	86	2	16081819
Pubmed	EZH1 in germ cells safeguards the function of PRC2 during spermatogenesis.	SUZ12 DDX4	2.15e-04	9	86	2	28254491
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	HIGD1A AMFR IPO9 RPN2 SUPT16H MRPS9 EMC2 FLOT1 VPS53 BAG6 DYNC1H1 PGM3	2.18e-04	1440	86	12	30833792
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	DYNC2H1 DNAH2 DYNC1H1	2.19e-04	47	86	3	8812413
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	GBF1 IPO9 DYNC2H1 SCAPER MACF1 EIF2AK1 EMC2	2.26e-04	493	86	7	15368895
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	AMPD1 SGCG SYNE1 SUPT16H MACF1 RYR1 TTC19	2.37e-04	497	86	7	23414517
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	GBF1 NRXN2 SYNE1 MACF1 ADGRV1	2.47e-04	225	86	5	12168954
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	IPO9 RPN2 SCAPER DNAH2 MACF1 EMC2 FLOT1 BAG6 DYNC1H1	2.49e-04	847	86	9	35235311
Pubmed	Dynein and kinesin regulate stress-granule and P-body dynamics.	DNAH2 DYNC1H1	2.68e-04	10	86	2	19825938
Pubmed	Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms.	CSF1R CFB	2.68e-04	10	86	2	8706013
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TTLL12 GBF1 IPO9 FMN2 MACF1 CDC25C PLK4 BICC1 OTOG	2.81e-04	861	86	9	36931259
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	GBF1 DYNC2H1 SEC23IP TCIRG1 MACF1 SPG11 OSMR EMC2 BAG6 BICC1	2.91e-04	1061	86	10	33845483
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TTLL12 ANK3 DSCAM SYNE1 SEC23IP MRPS9 FMN2 MACF1 EIF2AK1 FLOT1 DYNC1H1	3.25e-04	1285	86	11	35914814
Pubmed	USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.	AMFR BAG6	3.28e-04	11	86	2	24424410
Pubmed	Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.	ANK3 SYNE1	3.28e-04	11	86	2	20351715
Pubmed	gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.	AMFR BAG6	3.28e-04	11	86	2	26424800
Pubmed	Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.	SUZ12 TEFM	3.93e-04	12	86	2	17632510
Pubmed	A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.	AMFR BAG6	3.93e-04	12	86	2	21636303
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	ANK3 SCN8A	3.93e-04	12	86	2	30175250
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	IPO9 ANK3 DYNC2H1 SEC23IP SUPT16H EIF2AK1 CDC25C VPS53 DYNC1H1 PGM3 TEFM	4.10e-04	1321	86	11	27173435
Pubmed	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	SLC19A1 CALCRL OSMR RYR1	4.48e-04	143	86	4	20424473
Pubmed	A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation.	FASTKD2 TEFM	4.63e-04	13	86	2	27667664
Pubmed	Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse.	SUZ12 TEFM	4.63e-04	13	86	2	12696059
Pubmed	Cytoplasmic dynein nomenclature.	DYNC2H1 DYNC1H1	4.63e-04	13	86	2	16260502
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	AMFR VPS52 INTS14 RPN2 SYNE1 CDC25C DYNC1H1	5.55e-04	573	86	7	28330616
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	IPO9 RPN2 MRPS9 DYNC1H1 PGM3	5.86e-04	272	86	5	25315684
Pubmed	Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.	SUZ12 BAG6	6.21e-04	15	86	2	29295817
Pubmed	Upstream open reading frames control PLK4 translation and centriole duplication in primordial germ cells.	PLK4 DDX4	6.21e-04	15	86	2	35772791
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	TCIRG1 SIGLEC1 VPS53 BAG6	6.21e-04	156	86	4	30409884
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	OMA1 RPN2 TCIRG1 EMC2 FLOT1 DYNC1H1	6.39e-04	422	86	6	27342126
Pubmed	Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.	CSF1R BAG6	7.09e-04	16	86	2	20098615
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	AMFR GBF1 SUPT16H VPS53 BAG6	7.58e-04	288	86	5	23383273
Pubmed	Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.	MACF1 DYNC1H1	8.02e-04	17	86	2	20395553
Pubmed	Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers.	AMFR RPN2	8.02e-04	17	86	2	32938586
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	TECTB OTOG	8.02e-04	17	86	2	20856818
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	ANK3 RPN2 DYNC2H1 SYNE1 SCN8A MACF1 DYNC1H1 RYR1	8.76e-04	807	86	8	30575818
Pubmed	Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.	ANK3 SCN8A	9.01e-04	18	86	2	37321992
Pubmed	Defining human ERAD networks through an integrative mapping strategy.	AMFR IPO9 RPN2 EMC2	9.14e-04	173	86	4	22119785
Pubmed	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	VPS52 FLOT1 BAG6 CFB	9.54e-04	175	86	4	19851445
Pubmed	Bioinformatics and cellular signaling.	ELMO3 FCRLA BAG6 RYR1	1.10e-03	182	86	4	15102471
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	SYNE1 MACF1	1.12e-03	20	86	2	21689717
Pubmed	The role of RNF149 in the pre-emptive quality control substrate ubiquitination.	EMC2 BAG6	1.12e-03	20	86	2	37031316
Pubmed	Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line.	UBR1 RASGRP1	1.12e-03	20	86	2	17082620
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DYNC2H1 SYNE1 RTTN PGM3	1.22e-03	187	86	4	26460568
Cytoband	1p32.2-p32.1	OMA1 NRDC	3.47e-06	2	86	2	1p32.2-p32.1
Cytoband	10q25-q26	SEC23IP TECTB	2.08e-05	4	86	2	10q25-q26
Cytoband	6p21.3	VPS52 OR1F12P FLOT1 BAG6 CFB	1.12e-04	250	86	5	6p21.3
GeneFamily	Dyneins, cytoplasmic	DYNC2H1 DYNC1H1	7.98e-04	13	59	2	538
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	TBC1D16 CSF1R EPHA6 TCIRG1 CALCRL BICC1 RYR1	1.23e-07	200	86	7	be1abe5bb1ce4e7dfec63af4ed0fc5b96bf77866
ToppCell	distal-Hematologic-Plasma-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	AMPD1 ORMDL3 EPHA6 SLC17A9 FCRLA MEI1	2.16e-06	195	86	6	4280a5bc5ed9bb12e278b182e0be6cb88fa83d83
ToppCell	distal-Hematologic-Plasma\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	AMPD1 ORMDL3 EPHA6 SLC17A9 FCRLA MEI1	2.23e-06	196	86	6	2a11dc1e51c64af7705e1622a9da583a6634c563
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DYNC2H1 SYNE1 MACF1 OSMR SLC40A1 BICC1	2.43e-06	199	86	6	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ABCC9 DEPDC1 CDC25C SLC40A1	1.57e-05	162	86	5	b502d6af6868425b5c919740e011330c0d3cf3b8
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 SLC40A1 TLR8	1.92e-05	169	86	5	aec1b4c7e973a31c53aaea47c2c05d24ce16aa4f
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF536 INTS14 ANK3 SIGLEC1 PLK4	2.60e-05	180	86	5	da723df348d7b8449bb1124f23fe6fa706412adb
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-Macrophages\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CSF1R SIGLEC1 SLC40A1 TLR8 ETV3L	2.60e-05	180	86	5	7af90f0e7ca001bf1fe5c860ee54c4cc8eb483bf
ToppCell	droplet-Heart-nan-3m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF536 INTS14 ANK3 SIGLEC1 PLK4	2.60e-05	180	86	5	5b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF536 INTS14 ANK3 SIGLEC1 PLK4	2.60e-05	180	86	5	50758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS19 RASGRP1 SGCG ABCC9 CALCRL	2.67e-05	181	86	5	08f44323bf71b6004a921bbc969c954c75feeb66
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	ANK3 SYNE1 ABCC9 ADGRV1 OSMR	2.81e-05	183	86	5	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	OMA1 ZNF536 ANK3 CALCRL BICC1	3.20e-05	188	86	5	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	OMA1 ZNF536 ANK3 CALCRL BICC1	3.20e-05	188	86	5	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	OMA1 ZNF536 ANK3 CALCRL BICC1	3.20e-05	188	86	5	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	Int-URO-Lymphocyte-T_NK-T_NK_proliferative\|Int-URO / Disease, Lineage and Cell Type	SCN8A DEPDC1 CDC25C PLK4 OR2AE1	3.36e-05	190	86	5	005967c540418b85311308072a07c684f4296aef
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	ADAMTS19 EPHA6 DYNC2H1 CALCRL BICC1	3.36e-05	190	86	5	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CSF1R ARHGAP30 SIGLEC1 RNF175 RYR1	3.62e-05	193	86	5	bd08555f02db8bc903caacae57e80bb91e2556ce
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBC1D16 CSF1R SIGLEC1 SLC40A1 RYR1	3.71e-05	194	86	5	7c7091de47359760003e910cfbe63db5c99410d6
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF536 SGCG FMN2 ABCC9 IKZF4	3.81e-05	195	86	5	d32716a12014522492becbde1088dc1106308490
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CSF1R ARHGAP30 SIGLEC1 SLC40A1 RYR1	3.81e-05	195	86	5	42bfdff88da1d07828c0ad65d412fb1752f0cee4
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 SCAPER FMN2 MACF1 DYNC1H1	3.81e-05	195	86	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF536 SGCG FMN2 ABCC9 IKZF4	3.81e-05	195	86	5	b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 SCAPER FMN2 MACF1 DYNC1H1	3.81e-05	195	86	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN2 ABCC9 OSMR BICC1 CFB	3.90e-05	196	86	5	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN2 ABCC9 OSMR BICC1 CFB	3.90e-05	196	86	5	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	TCGA-Skin-Metastatic-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	CSF1R ABCC9 CALCRL SLC40A1 TLR8	4.09e-05	198	86	5	af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CSF1R SIGLEC1 RNF175 PLK4 RYR1	4.09e-05	198	86	5	2b724d2a36843801984d46a969d33149b76c9771
ToppCell	TCGA-Skin-Metastatic\|TCGA-Skin / Sample_Type by Project: Shred V9	CSF1R ABCC9 CALCRL SLC40A1 TLR8	4.09e-05	198	86	5	ad39cce004867f083f8da1954e0cf5a263815184
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	CSF1R ABCC9 CALCRL SLC40A1 TLR8	4.09e-05	198	86	5	62cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCell	Sigmoid-Dendritic_cell-cycling_DCs\|Sigmoid / Region, Cell class and subclass	CSF1R DEPDC1 CDC25C SLC40A1 PLK4	4.19e-05	199	86	5	bd6f8c0f79e9a94cc0f8c6105d38851463de821c
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMPD1 DEPDC1 FCRLA CDC25C PLK4	4.19e-05	199	86	5	c9d15c84b9f8c87b4ea0008be7d5efc5f45efd1a
ToppCell	Sigmoid-(5)_Dendritic_cell-(52)_cycling_DCs\|Sigmoid / shred on region, Cell_type, and subtype	CSF1R DEPDC1 CDC25C SLC40A1 PLK4	4.19e-05	199	86	5	8ee78a39729633bcbb3ab17e1dfaca33f38db569
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SYNE1 MACF1 OSMR SLC40A1 BICC1	4.19e-05	199	86	5	e1849505b92820a219c5a2c35492bdd55579fb48
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DYNC2H1 SYNE1 MACF1 OSMR BICC1	4.29e-05	200	86	5	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	RPN2 SUPT16H SPG11 DYNC1H1 TTC19	4.29e-05	200	86	5	e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Glia_progenitor_cell\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	CSF1R EPHA6 TCIRG1 CALCRL RYR1	4.29e-05	200	86	5	4b937b1d0179d1d0e51931f35720e205d460a07e
ToppCell	LPS_only-Unknown-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 SGCG ABCC9 TLR8	7.32e-05	115	86	4	ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCell	LPS_only-Unknown\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 SGCG ABCC9 TLR8	7.32e-05	115	86	4	7a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCell	LPS_only-Unknown-Endothelial-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS19 SGCG ABCC9 TLR8	7.32e-05	115	86	4	c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCell	primary_visual_cortex-Non-neuronal-macrophage-Macrophage-PVM_Mrc1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CSF1R ARHGAP30 SIGLEC1 TLR8	1.18e-04	130	86	4	3a0846b74ba34bd0e2a05b4f1f39f3940df93780
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-AT1_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ELMO3 NRXN2 MRPS9 CALCRL	1.79e-04	145	86	4	186b8bd8ac2d5c66cc29fdc2dd6751eddce3e8b8
ToppCell	droplet-Pancreas-Exocrine-18m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 TLR8 RYR1	1.89e-04	147	86	4	684e2d8d2f0516cf8b0dc53efa7efc3050bbf0d1
ToppCell	droplet-Pancreas-Exocrine-18m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 TLR8 RYR1	1.89e-04	147	86	4	c031fad0a4e192019775809968e46da54a111d27
ToppCell	frontal_cortex-Non-neuronal-macrophage-Macrophage-PVM_Mrc1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CSF1R ARHGAP30 SIGLEC1 TLR8	1.94e-04	148	86	4	d3ea907f8f408e9bb97ed223a3089e403e35f911
ToppCell	Ciliated_cells-B-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	ADAMTS19 ZNF536 DNAH2 BICC1	1.99e-04	149	86	4	6399c5a2f06d79f020dece252526f1c0c110d569
ToppCell	COVID-19_Mild\|World / 5 Neutrophil clusters in COVID-19 patients	ANK3 NRDC SIGLEC1 ADGRV1	2.14e-04	152	86	4	2ff0980dfd8d430cca14649151d856edef115720
ToppCell	facs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNC2H1 FMN2 SIGLEC1 TLR8	2.20e-04	153	86	4	0ef7c45cdd854c79e527006034029767f8e108b2
ToppCell	facs-Marrow-KLS-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM ABCC9 ADGRV1 BICC1	2.25e-04	154	86	4	37765512dfae557b9f6eb30a29463b93682a4404
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CSF1R TECTB SLC40A1 TLR8	2.31e-04	155	86	4	93bfcf5c12cbb61a1e0444312afd2aa411a8bf50
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	ZNF536 EPHA6 DSCAM RYR1	2.55e-04	159	86	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FMN2 FASTKD2 SLC40A1 TEFM	2.55e-04	159	86	4	b1d5ebd0c186b6d0279dab20d8f3b4a915acdc1f
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHA6 PDILT SIGLEC1 ADGRV1	2.73e-04	162	86	4	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL12 RASGRP1 SLC17A9 IKZF4	2.80e-04	163	86	4	4af92b211d12c5b88b65bb746242cd702b545bd0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DEPDC1 CDC25C PLK4 DDX4	2.80e-04	163	86	4	3f434015c0cbefb31eeda133c34f75384c5f7e22
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL12 RASGRP1 SLC17A9 IKZF4	2.80e-04	163	86	4	d24774e0aa612322c22fdb3b314aef275fa01d68
ToppCell	droplet-Heart-nan-3m-Hematologic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SLC40A1 TLR8	2.86e-04	164	86	4	df9fe446c1a43100048e11c01bf009bec3414dcf
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R DSCAM TCIRG1 ADGRV1	2.86e-04	164	86	4	b77995958c938e10a526118f75d78cee72e0b207
ToppCell	facs-SCAT-Fat-3m-Myeloid-myeloid_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 TLR8	3.00e-04	166	86	4	8395c74db8e4e54af97a3f2b75cb75171140ec31
ToppCell	facs-SCAT-Fat-3m-Myeloid\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 TLR8	3.00e-04	166	86	4	76807edc5620514b53a14be354b84c54c112b8f9
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-plasma_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AMPD1 SLC17A9 FCRLA MEI1	3.00e-04	166	86	4	a1009d25c5a500f470e8edb04097ac47d4d72f3c
ToppCell	facs-SCAT-Fat-3m-Myeloid-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 TLR8	3.00e-04	166	86	4	645b842b94b8d2f4b26c2623f8589f56bd782c26
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AMPD1 SLC17A9 FCRLA MEI1	3.00e-04	166	86	4	5a6e3364d223829f66e8da7f3560d95fd8bb9b11
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AMPD1 SLC17A9 FCRLA MEI1	3.00e-04	166	86	4	e25bcbb5b3ba453a6e2572637f2521a32223a3ad
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DSCAM DNAH2 CDC25C RYR1	3.07e-04	167	86	4	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	droplet-Heart-nan-3m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SLC40A1 TLR8	3.07e-04	167	86	4	47447bcf184b1ad24ef17e135199fe7cd1d73c02
ToppCell	droplet-Kidney-nan-24m-Myeloid-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R DNAH2 ARHGAP30 RYR1	3.07e-04	167	86	4	2ee1660be117e20f24557522345572d11cbee813
ToppCell	droplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l34\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CSF1R SCN8A FCRLA TLR8	3.14e-04	168	86	4	84977db9d71e59208727885320cc18d80d064380
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_1\|390C / Donor, Lineage, Cell class and subclass (all cells)	CSF1R DEPDC1 RNF175 CDC25C	3.14e-04	168	86	4	2082b15fc7935a211f1c61506b305af5501a21ad
ToppCell	facs-Heart-RV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 TLR8	3.14e-04	168	86	4	8ee57814c7e9d45444f48b6b269c4d535bc4d5e1
ToppCell	facs-Heart-RV-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 TLR8	3.14e-04	168	86	4	c1a5f4f4d32a1f8583048db709a7037cc9357ad8
ToppCell	facs-Heart-RV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 TLR8	3.14e-04	168	86	4	a405f0de70293f68b4e000c1fc8a9ad33d56539a
ToppCell	droplet-Heart-nan-3m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SLC40A1 TLR8	3.14e-04	168	86	4	a4eebc78babb9b5ef33065b0642793820195a613
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP30 SIGLEC1 RNF175 CDC25C	3.21e-04	169	86	4	c3d410a5e98000ba872141b62e17ef4ed3d1a8eb
ToppCell	facs-Lung-nan-3m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R TCIRG1 ARHGAP30 TLR8	3.21e-04	169	86	4	05b138511039f1255a5f647040b1b9bdf222bd52
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R SIGLEC1 SLC40A1 TLR8	3.21e-04	169	86	4	44d841fd997a6f26104f16cd00223ecce8352f43
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 SLC40A1	3.21e-04	169	86	4	0f5e737b265ba333275a0cd289dab029a1542075
ToppCell	facs-Lung-nan-3m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R TCIRG1 ARHGAP30 TLR8	3.21e-04	169	86	4	bf0a97f53d6e3f9ffeaeae0402b010c49a6cccb7
ToppCell	-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	RASGRP1 AMPD1 FCRLA MEI1	3.28e-04	170	86	4	601630644f09133ee4c5e64499460b55cf3e80a0
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF536 DEPDC1 SLC40A1 PLK4	3.36e-04	171	86	4	913bae728b5e653771a27c79a309eb023699f1d0
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF536 DEPDC1 SLC40A1 PLK4	3.36e-04	171	86	4	f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCell	droplet-Trachea-3m-Hematologic-myeloid-granulocyte-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CSF1R ARHGAP30 DEPDC1 SIGLEC1	3.36e-04	171	86	4	41932c9e70829ee3d55ca5fdb74d290fc8229416
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP30 DEPDC1 FCRLA CDC25C	3.36e-04	171	86	4	55c7bf7211587fa08df13c0a4ff5b78a85d5439e
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D16 OMA1 DSCAM FCRLA	3.43e-04	172	86	4	356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D16 OMA1 DSCAM FCRLA	3.43e-04	172	86	4	46fadeee483fdf8402df92ec98575a09c6c15b16
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CSF1R SIGLEC1 SLC40A1 TLR8	3.43e-04	172	86	4	f0e767a20d93e546ce278db67dbd779cc68af533
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS19 ZNF536 FMN2 ALS2CL	3.43e-04	172	86	4	6c17a1e586a72d1bd80c20c06370429c61dc9f85
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D16 OMA1 DSCAM FCRLA	3.43e-04	172	86	4	438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D16 ELMO3 MEI1 CFB	3.51e-04	173	86	4	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	5'-Adult-Appendix-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMPD1 SLC17A9 MEI1 OR2AE1	3.51e-04	173	86	4	68bcc0eee15df9cf3516c641709154301bd7b38f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AMPD1 ARHGAP30 FCRLA MEI1	3.51e-04	173	86	4	62ba49c1c16760a8c6cde0cc44e068f94386946a
ToppCell	facs-Heart-LA-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 TLR8	3.58e-04	174	86	4	30c083fe4711735e83dccfd00fcd746ae673d353
ToppCell	facs-Heart-LV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 TLR8	3.58e-04	174	86	4	54166a0faf748cccb6406c2c268e1e6e21caf6d0
ToppCell	facs-Heart-LA-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 TLR8	3.58e-04	174	86	4	46d19c1144fff19be682b7ba59d4c3e014f79e15
ToppCell	facs-Heart-LA-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 TLR8	3.58e-04	174	86	4	1802a52552256d1e25d8b328ba62dcfe41671900
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	CSF1R RNF175 CDC25C PLK4	3.58e-04	174	86	4	a75ba49ccea6bd3d78ada1092b46deb5202c58a5
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_macrophage\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CSF1R OR1F12P SIGLEC1 SLC40A1	3.58e-04	174	86	4	7f1e26b58b66f4ac4c3bc315354bd620ad782eaa
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DEPDC1 ADGRV1 CDC25C PLK4	3.58e-04	174	86	4	7b2f35add804981c7d588a996bdbca6ec11a1ca5
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_macrophage-macrophage\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CSF1R OR1F12P SIGLEC1 SLC40A1	3.58e-04	174	86	4	2479e4804253f55647d2192e40566d713419c51b
ToppCell	facs-Heart-LV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R ARHGAP30 SIGLEC1 TLR8	3.58e-04	174	86	4	dc8a238ec1d954bec0f8eb67c04a61734c96f5b5
Computational	Genes upregulated in subsets of cells of a given type within various tumors	RASGRP1 SYNE1 MACF1 DYNC1H1	9.47e-05	49	53	4	GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
Drug	coproporphyrin III	SGCG TCIRG1 SIGLEC1 DYNC1H1	5.46e-06	32	83	4	CID000114935
Drug	Perhexiline maleate [6724-53-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	CSF1R ANK3 SCAPER OSMR EIF2AK1 GTDC1 PLK4	7.52e-06	196	83	7	5081_DN
Disease	Intellectual Disability	NRXN2 SYNE1 RTTN SUPT16H SCN8A SCAPER MACF1 SUZ12 VPS53 DYNC1H1 PGM3	5.17e-08	447	83	11	C3714756
Disease	Cerebellar Ataxia	SYNE1 SCN8A	7.77e-05	5	83	2	C0007758
Disease	Abnormal corpus callosum morphology	SUPT16H SUZ12	1.16e-04	6	83	2	C1842581
Disease	nervous system disorder	SLC19A1 SCN8A TTC19	4.54e-04	53	83	3	C0027765
Disease	Papillary Renal Cell Carcinoma	ZNF536 FMN2 RNF139 RYR1	4.76e-04	128	83	4	C1306837
Disease	Renal Cell Carcinoma	ZNF536 FMN2 RNF139 RYR1	4.76e-04	128	83	4	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	ZNF536 FMN2 RNF139 RYR1	4.76e-04	128	83	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	ZNF536 FMN2 RNF139 RYR1	4.76e-04	128	83	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	ZNF536 FMN2 RNF139 RYR1	4.76e-04	128	83	4	C1266044
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	ZNF536 FMN2 RNF139 RYR1	8.21e-04	148	83	4	C0279702
Disease	coronary thrombosis, GM11992	DSCAM SCAPER	9.14e-04	16	83	2	EFO_0001124, EFO_1000883
Disease	cortical thickness	OMA1 ZNF536 SLC19A1 FMN2 MACF1 ABCC9 ADGRV1 CALCRL OSMR ETV3L	1.12e-03	1113	83	10	EFO_0004840
Disease	small cell lung carcinoma	DYNC2H1 ADGRV1 BAG6	1.51e-03	80	83	3	EFO_0000702
Disease	systemising measurement	ORMDL3 DSCAM	1.59e-03	21	83	2	EFO_0010221
Disease	Primary microcephaly	RTTN PLK4	1.74e-03	22	83	2	C0431350
Disease	triacylglycerol 58:9 measurement	GBF1 FASTKD2	1.74e-03	22	83	2	EFO_0010443
Disease	unipolar depression	TBC1D16 AMFR RASGRP1 ZNF536 IPO9 NRDC DYNC2H1 OR2T12 MEI1 CFB	2.03e-03	1206	83	10	EFO_0003761
Disease	lateral orbital frontal cortex volume measurement	OMA1 OTOG	2.07e-03	24	83	2	EFO_0010312
Disease	congestive heart failure (is_implicated_in)	AMPD1 RYR1	2.62e-03	27	83	2	DOID:6000 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
IQHLGAEIHLIRDMM	ALS2CL	896	Q60I27
KAEHLDHVMFRMGLL	PGM3	31	O95394
AFLLPILAHMMHDGI	DDX4	341	Q9NQI0
ILAHMMHDGITASRF	DDX4	346	Q9NQI0
LGMHMLESVQVFHAL	C2orf78	626	A6NCI8
NFSMVDVVMLLHGHF	BAG6	761	P46379
LAHITQFRMMVSLGH	RASGRP1	41	O95267
LTHMMAASLGTQILF	ADGRV1	5941	Q8WXG9
HLHLFMPAVMGFVAT	ABCC9	101	O60706
HLMTAFMIADDISHG	AMPD1	581	P23109
STQLDIAAQHHLFMM	BICC1	286	Q9H694
EHSSMLIHILLPMVF	OSMR	736	Q99650
LAFTIAHEMGHNMGI	ADAMTS19	476	Q8TE59
MSIHLIHMRVAAQGF	HIGD1A	56	Q9Y241
GHNMLLDVMHTVHQF	PARN	286	O95453
RHVIILMTDGLHNMG	CFB	381	P00751
IAILNPLLHTLMMAH	OR1F12P	151	Q8NHA8
FNHTRAHQVLFMMLL	OR2T12	16	Q8NG77
MLVCMLLAHQNHLEG	EFCAB9	86	A8MZ26
LETLEGHQRAIMAHM	FLOT1	101	O75955
AHMRLEFHNIETGIM	NRXN2	851	Q9P2S2
LHDAMGTRSLMIHTF	DEPDC1	636	Q5TB30
HGDLDLVMNLMDAHK	MACF1	6691	Q9UPN3
EVHLAGMNHDQHLMK	CDC25C	106	P30307
ELVMEHGNLMEHLLR	MEI1	171	Q5TIA1
GASVNSLIHMAILMH	OR2AE1	151	Q8NHA4
ADQLMFALHFVRGMH	DYNC2H1	3566	Q8NCM8
MSELKIMSHLGQHEN	CSF1R	631	P07333
YHLMLHIQMQLCELS	EIF2AK1	376	Q9BQI3
HLYHQMGLLLKHMQD	FCRLA	316	Q7L513
AAHGLTMLFEHMATN	INTS14	31	Q96SY0
HFHSMTLLMLGLLTN	MT-CO3	36	P00414
MFLPHMNHLTLEQTF	C1orf112	1	Q9NSG2
AFMGHVNIVSQLMHH	ANK3	441	Q12955
DEMAHHLYVLQALML	ELMO3	276	Q96BJ8
VMQSLIMVFAHLVHT	IPO9	801	Q96P70
VARGMLHQDHITFAM	DYNC1H1	3871	Q14204
LLAMAHMFVSTNLGE	DYNC1H1	4001	Q14204
HNSEVMIHMGLHLLT	GBF1	421	Q92538
MIHMGLHLLTVALES	GBF1	426	Q92538
FCLEELMMTNPHNHL	EMC2	176	Q15006
SELLHSMLFAHQAMV	ETV3L	161	Q6ZN32
MHLKDLGLNFHVSVL	GTDC1	306	Q4AE62
LMSSLHLDMKDIQHA	FMN2	1371	Q9NZ56
LLQLAEHMGMAQRFH	DNAH2	3851	Q9P225
KMAIFLQHAAGLLHA	SCAPER	1131	Q9BY12
MLHQEGHMDDALSLT	RYR1	376	P21817
TLHLHMIFLRGMLTL	BVES	61	Q8NE79
DYIMHILMHFQGLLV	CALCRL	366	Q16602
RILFLDHVMFTIHMG	IKZF4	536	Q9H2S9
LTNLIHNMGMYIFLH	ORMDL3	51	Q8N138
MHHLLEQSADMATAL	PANX2	1	Q96RD6
EFLMRHLVHMASFSA	ARHGAP30	146	Q7Z6I6
FCLVMLNMTHLAHQV	OTOG	2166	Q6ZRI0
TLRLHMMHIQEKGFH	EPHA6	1021	Q9UF33
ELHIMSHMLLFVSKS	PDILT	271	Q8N807
MCLLLTAVLHFIHGM	RNF139	356	Q8WU17
RITGINHENLIMDHM	DSCAM	361	O60469
TILCLLHLSHEMMAQ	RTTN	1326	Q86VV8
LHLSHEMMAQAGSLE	RTTN	1331	Q86VV8
HEMSHGLLLMLENID	SYNE1	8556	Q8NF91
QHMFEVLAAMNHRSL	FASTKD2	346	Q9NYY8
AHLAFMTFSRILMGL	SLC17A9	116	Q9BYT1
CGIILMMVFLHKHEL	SLC40A1	106	Q9NP59
SFSDVLHHLIMMLGI	TECTB	311	Q96PL2
ILLHFHIMEAMLYAL	TEFM	246	Q96QE5
GMEINHLHALFMSRN	SEC23IP	556	Q9Y6Y8
AHFLLVMLSMLTLQH	HERC2P3	511	Q9BVR0
NEARHFMHQIITGML	PLK4	111	O00444
MIIVLHFHLKNAIMF	SUPT16H	716	Q9Y5B9
AGMVHLLDFLGMIFL	OMA1	341	Q96E52
LSQMDILFHSSDGML	SGCG	221	Q13326
HGMHTLAFMAAESLL	AMFR	211	Q9UKV5
LTLLSLDLMHHIHML	AMFR	266	Q9UKV5
LDLMHHIHMLLFGNI	AMFR	271	Q9UKV5
HMEGIIRVLQAAHML	SPG11	2131	Q96JI7
AHDLFHAVMGRTLSM	VPS52	411	Q8N1B4
ELHMVLSNLAAVLMH	TTC19	316	Q6DKK2
FFITTMVMLAALAHH	TLR8	836	Q9NR97
DIAFGTHHTKMMLLL	TDP1	256	Q9NUW8
LMLAHHTLSILGIIM	TLCD5	101	Q6ZRR5
LMHDVYGMLLNLEKH	MRPS9	161	P82933
TIIFHLGHAAMLGLM	RPN2	576	P04844
RGHDSMHVEMILIFL	RNF175	46	Q8N4F7
NLCRNFMLHLVSMHD	SUZ12	651	Q15022
FMLHLVSMHDFNLIS	SUZ12	656	Q15022
LLGHSVAHMQLMELF	SLC19A1	111	P41440
LATDQMLLHFGNLAM	TBC1D16	661	Q8TBP0
LYLFHLITMAHMLQI	UBR1	1436	Q8IWV7
LAHFLEHMVFMGSLK	NRDC	231	O43847
ICIVLNTLFMAMEHH	SCN8A	761	Q9UQD0
LSALLDMGQGHMALF	SIGLEC1	801	Q9BZZ2
LLHRMANLMGIEFHG	TTLL12	141	Q14166
HLHMLAGGVDSLEAM	VPS53	151	Q5VIR6
SSMELMALHLQANHL	ZNF536	1011	O15090
DVGHGLLMFLFALAM	TCIRG1	406	Q13488