Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	C21-steroid hormone biosynthetic process	SCP2 HSD3B2 CYP11B1	2.12e-05	26	43	3	GO:0006700
GeneOntologyBiologicalProcess	hormone biosynthetic process	TPO SCP2 HSD3B2 CYP11B1	2.67e-05	83	43	4	GO:0042446
GeneOntologyBiologicalProcess	C21-steroid hormone metabolic process	SCP2 HSD3B2 CYP11B1	1.13e-04	45	43	3	GO:0008207
GeneOntologyBiologicalProcess	steroid hormone biosynthetic process	SCP2 HSD3B2 CYP11B1	1.64e-04	51	43	3	GO:0120178
HumanPheno	Elevated circulating 17-hydroxyprogesterone concentration	HSD3B2 CYP11B1	2.42e-05	3	15	2	HP:0031213
HumanPheno	Increased circulating progesterone	HSD3B2 CYP11B1	4.84e-05	4	15	2	HP:0031216
HumanPheno	Congenital adrenal hyperplasia	HSD3B2 CYP11B1	8.05e-05	5	15	2	HP:0008258
HumanPheno	Abnormal circulating progesterone level	HSD3B2 CYP11B1	1.21e-04	6	15	2	HP:0031212
MousePheno	delayed head development	BTAF1 FBXL19	1.72e-05	3	34	2	MP:0012177
Domain	Cyt_P450_CS	CYP11B1 CYP26C1	6.62e-03	53	43	2	IPR017972
Domain	CYTOCHROME_P450	CYP11B1 CYP26C1	7.63e-03	57	43	2	PS00086
Domain	-	CYP11B1 CYP26C1	7.89e-03	58	43	2	1.10.630.10
Domain	p450	CYP11B1 CYP26C1	7.89e-03	58	43	2	PF00067
Domain	Cyt_P450	CYP11B1 CYP26C1	8.42e-03	60	43	2	IPR001128
Domain	MFS	SLC16A13 SLC17A1	1.36e-02	77	43	2	IPR011701
Domain	MFS_1	SLC16A13 SLC17A1	1.36e-02	77	43	2	PF07690
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	HSD3B2 CYP11B1	2.22e-04	10	32	2	M27076
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	HSD3B2 CYP11B1	2.71e-04	11	32	2	MM14750
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	HSD3B2 CYP11B1	3.25e-04	12	32	2	MM14749
Pubmed	Myeloid cells are capable of synthesizing aldosterone to exacerbate damage in muscular dystrophy.	HSD3B2 CYP11B1	4.36e-05	8	44	2	27798095
Pubmed	Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production.	HSD3B2 CYP11B1	5.60e-05	9	44	2	12399432
Pubmed	Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex.	HSD3B2 CYP11B1	8.54e-05	11	44	2	18599507
Pubmed	Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.	LTBP3 SLC17A1 BCAS3	8.55e-05	67	44	3	23263486
Pubmed	Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung.	HSD3B2 CYP11B1	1.21e-04	13	44	2	24580729
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	POLR1B REXO4 LTBP3 MAPK7 TAP2 NEURL4 BCAS3	1.49e-04	925	44	7	28986522
Pubmed	Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure.	HSD3B2 CYP11B1	1.86e-04	16	44	2	37727456
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	HOXC13 NEURL4 BCAS3 UBR4	2.16e-04	233	44	4	37704626
Pubmed	Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors.	HSD3B2 CYP11B1	2.36e-04	18	44	2	25933105
Pubmed	Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.	SLC17A1 CYP11B1	2.64e-04	19	44	2	7628695
Pubmed	WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.	HSD3B2 CYP11B1	2.93e-04	20	44	2	24135228
Pubmed	Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex.	HSD3B2 CYP11B1	4.61e-04	25	44	2	30541888
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	POLR1B BTAF1 TTC13 REXO4	4.63e-04	285	44	4	32838362
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIAA1549 TRIOBP USP34 CDK14 SNX17	5.32e-04	529	44	5	14621295
Pubmed	MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation.	HSD3B2 CYP11B1	5.79e-04	28	44	2	29879378
Pubmed	Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes.	HSD3B2 CYP11B1	5.79e-04	28	44	2	25668066
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	BTAF1 HOXC13 ZNF268 BCAS3 SNX17 UBR4	6.99e-04	857	44	6	25609649
Pubmed	Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.	HSD3B2 CYP11B1	7.11e-04	31	44	2	15583024
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	POLR1B FASTK PPFIA4 SNX17	7.92e-04	329	44	4	17474147
Pubmed	[IMAGE: molecular integration of the analysis of the human genome and its expression].	C21orf58 FASTK	9.06e-04	35	44	2	7757816
Pubmed	A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.	HSD3B2 CYP11B1	1.01e-03	37	44	2	26108225
Pubmed	F-box only protein 9 is an E3 ubiquitin ligase of PPARγ.	TRIOBP HTR3D	1.18e-03	40	44	2	27197753
ToppCell	Substantia_nigra-Macroglia-OLIGODENDROCYTE-O2-Tfr-Oligodendrocyte.Tfr.Ndrg2_(Ndrg2)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	HOXC13 C21orf58 CYP26C1	3.17e-05	62	44	3	19867e62ca7e024572192a2654e2eb8f226bdd60
ToppCell	Substantia_nigra-Macroglia-OLIGODENDROCYTE-O2-Tfr-Oligodendrocyte.Tfr.Ndrg2_(Ndrg2)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	HOXC13 C21orf58 CYP26C1	3.17e-05	62	44	3	f7697057fb5568368ec7edead2bcdd25ede7627b
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KIAA1549 FBXL19 ZNF785 PPFIA4	3.30e-05	185	44	4	636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Bcl11b-Inhibitory_Gad1Gad2_Id2.Bcl11b_(Interneuron,_Neurogliaform2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	HOXC13 SLC17A1 DGKK	4.18e-05	68	44	3	cfd75c373e10b3761666ccd445ba74755efeb95f
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Bcl11b\|Hippocampus / BrainAtlas - Mouse McCarroll V32	HOXC13 SLC17A1 DGKK	4.18e-05	68	44	3	c25fb921dc83eecdc337353894829ae6b5192353
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Bcl11b-Inhibitory_Gad1Gad2_Id2.Bcl11b_(Interneuron,_Neurogliaform2)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	HOXC13 SLC17A1 DGKK	4.18e-05	68	44	3	712f5f4d3a1e0c0db1a340332876206b93bdac31
Disease	Hypospadias	HSD3B2 DGKK	2.17e-05	5	44	2	C0848558
Disease	Disorder of endocrine system	HSD3B2 CYP11B1	2.17e-05	5	44	2	cv:C0014130
Disease	Congenital adrenal hyperplasia	HSD3B2 CYP11B1	2.17e-05	5	44	2	cv:C0001627
Disease	urate measurement	USP34 HSD3B2 REXO4 AURKAIP1 SLC17A1 TAP2 BCAS3 SNX17	4.67e-05	895	44	8	EFO_0004531
Disease	optic cup area measurement	TRIOBP LTBP3 BCAS3	8.11e-05	56	44	3	EFO_0006940
Disease	Acute monocytic leukemia	FANCG DNMT3A	6.90e-04	26	44	2	C0023465
Disease	Growth Disorders	LTBP3 DNMT3A	1.33e-03	36	44	2	C0018273
Disease	glaucoma	TRIOBP LTBP3 BCAS3	1.58e-03	154	44	3	MONDO_0005041
Disease	immunoglobulin isotype switching measurement	TAP2 UBR4	1.98e-03	44	44	2	EFO_0010128

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLRLDSRWSLPLTLM	HSD3B2	276	P26439
WESSLRQRPMPRLTF	DNMT3A	176	Q9Y6K1
SLEPLRWMLRSPFDR	ACTR5	86	Q9H9F9
DLPPRLWELTDMSSI	CDK14	421	O94921
MSRPQLRRWRLVSSP	CTBS	1	Q01459
MMTSPRASWTLVRTP	BCAS3	646	Q9H6U6
WPRMDLSRRKSLTPP	FBXL19	461	Q6PCT2
TIMLLPSRSEVSPWS	KIAA1549	706	Q9HCM3
ESWSPSPNSMLRVLL	FASTK	26	Q14296
RWTRMARPAAPALTS	MAPK7	571	Q13164
WSVMIRETPRQTPLL	DGKK	616	Q5KSL6
MKTIRLPRWLAASPT	FAM3D	31	Q96BQ1
ALPLTVTLRSPTWMR	PPFIA4	546	O75335
SGRLPRVTWISMSLA	TPO	841	P07202
PWASLLDMPLLRTLD	LRIT3	121	Q3SXY7
LSRTSSLLPKMSRLW	FANCG	421	O15287
NSSSWLIPILPDMLR	BTAF1	551	O14981
MARSRLPATSLRKPW	C21orf58	1	P58505
LRTPPLSSLREMWIS	FUT10	431	Q6P4F1
QLMFMPRSLSRWTSP	CYP11B1	236	P15538
LSTLPRMAPTWLSDI	CCHCR1	21	Q8TD31
RWMLSRDRASTLPLP	CYP26C1	36	Q6V0L0
ELISRPSPPTMRWFL	LTBP3	541	Q9NS15
MTTSLLLHPRWPESL	HOXC13	1	P31276
RMWSSIRLLSPVLSL	ERMARD	576	Q5T6L9
PSLPELRTKTTWMVS	NEURL4	996	Q96JN8
LLSPVMGLLSRAWSR	PPP1R15A	21	O75807
WESMARDRRPLLTAP	REXO4	401	Q9GZR2
LSSPLEMTVWVPRLP	TMEM132D	511	Q14C87
WAPPLERGRLTSMST	SLC17A1	161	Q14916
MRLPDLRPWTSLLLV	TAP2	1	Q03519
WSISPALEPMTTLLS	IL9R	166	Q01113
MSSSPWEPATLRRVF	SCP2	1	P22307
LVTSWRMPGDRPTLF	TRIOBP	1746	Q9H2D6
TPSISPSMDRARAWR	HTR3D	161	Q70Z44
PRKMSVSPLESWLTA	AURKAIP1	66	Q9NWT8
TRMRCWRVTSSVPLP	SNX17	316	Q15036
PVLWLDQMPARSLSR	TTC13	581	Q8NBP0
MATRVRTASIWVPPL	ZNF268	1	Q14587
VPGPVTRLLMLWTTL	SLC16A13	276	Q7RTY0
SRRVWELLMLLPTCP	USP34	1391	Q70CQ2
MRTTTVRRLLPESWG	POLR1B	481	Q9H9Y6
PVRLQAWLTRMTTSP	UBR4	1461	Q5T4S7
SPMNPWLKDTLTRRL	ZNF785	156	A8K8V0