Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	postsynaptic density membrane	PTPRF DLG2 DLG3 PRRT1 NOTCH1 EPHA4	3.82e-05	157	83	6	GO:0098839
GeneOntologyCellularComponent	synaptic membrane	CADM3 EFNB1 PTPRF DLG2 DLG3 HTR3C PRRT1 RIMS2 NOTCH1 EPHA4	1.03e-04	583	83	10	GO:0097060
GeneOntologyCellularComponent	postsynaptic specialization membrane	PTPRF DLG2 DLG3 PRRT1 NOTCH1 EPHA4	1.50e-04	201	83	6	GO:0099634
HumanPheno	Broad thumb	GDF5 TRPM3 POGZ RERE MED12 MEIS2	3.27e-05	90	36	6	HP:0011304
HumanPheno	Abnormal nasal tip morphology	TGFB3 FRAS1 EFNB1 PTPRF TRPM3 AUTS2 POGZ RERE CPT2 WDR26 MED12	4.36e-05	386	36	11	HP:0000436
HumanPheno	Brachycephaly	TGFB3 EFNB1 ERF SATB1 AUTS2 POGZ RERE WDR26 MED12	4.61e-05	253	36	9	HP:0000248
HumanPheno	Aplasia/Hypoplasia of the phalanges of the hand	GDF5 FRAS1 EFNB1 ERF TRPM3 POGZ RERE MED12 NOTCH1 MEIS2	4.74e-05	319	36	10	HP:0009767
HumanPheno	Broad phalanx	GDF5 EFNB1 TRPM3 POGZ RERE MED12 MEIS2	6.24e-05	148	36	7	HP:0006009
HumanPheno	Broad phalanges of the hand	GDF5 EFNB1 TRPM3 POGZ RERE MED12 MEIS2	6.24e-05	148	36	7	HP:0009768
HumanPheno	Broad finger	GDF5 EFNB1 TRPM3 POGZ RERE MED12 MEIS2	8.04e-05	154	36	7	HP:0001500
HumanPheno	Broad long bones	GDF5 EFNB1 TRPM3 POGZ RERE MED12 MEIS2	9.09e-05	157	36	7	HP:0005622
HumanPheno	High anterior hairline	EFNB1 SATB1 RERE MED12 MEIS2	1.70e-04	76	36	5	HP:0009890
HumanPheno	Broad hallux	GDF5 EFNB1 TRPM3 MED12 MEIS2	1.70e-04	76	36	5	HP:0010055
HumanPheno	Short phalanx of finger	GDF5 EFNB1 ERF TRPM3 POGZ RERE MED12 NOTCH1 MEIS2	2.01e-04	306	36	9	HP:0009803
HumanPheno	Short 2nd finger	GDF5 ERF MEIS2	2.06e-04	17	36	3	HP:0009536
HumanPheno	Broad foot	GDF5 MAGEL2 SATB1 POGZ RERE WDR26 DYNC1H1	2.07e-04	179	36	7	HP:0001769
HumanPheno	Abnormal 2nd finger morphology	GDF5 ERF MED12 MEIS2	2.13e-04	43	36	4	HP:0004100
HumanPheno	Widow's peak	EFNB1 SATB1 RERE	2.91e-04	19	36	3	HP:0000349
HumanPheno	Aplasia/Hypoplasia of the 2nd finger	GDF5 ERF MEIS2	2.91e-04	19	36	3	HP:0006264
HumanPheno	Flared metaphysis	GDF5 EFNB1 TRPM3 POGZ RERE MED12 MEIS2	3.09e-04	191	36	7	HP:0003015
HumanPheno	Broad toe	GDF5 EFNB1 TRPM3 MED12 MEIS2	3.22e-04	87	36	5	HP:0001837
Domain	Gamma_tubulin	TUBG2 TUBG1	1.90e-05	2	82	2	IPR002454
Domain	SH3_1	CACNB2 SRGAP1 DLG2 DLG3 SNX33 SPATA13	8.44e-05	164	82	6	PF00018
Domain	MAGUK_N_PEST	DLG2 DLG3	1.14e-04	4	82	2	PF10608
Domain	PDZ_assoc	DLG2 DLG3	1.14e-04	4	82	2	PF10600
Domain	DLG1_PEST_dom	DLG2 DLG3	1.14e-04	4	82	2	IPR019590
Domain	PDZ_assoc	DLG2 DLG3	1.14e-04	4	82	2	IPR019583
Domain	MAGUK_N_PEST	DLG2 DLG3	1.14e-04	4	82	2	SM01277
Domain	DLG1	DLG2 DLG3	1.14e-04	4	82	2	IPR016313
Domain	Guanylate_kin	CACNB2 DLG2 DLG3	1.97e-04	26	82	3	PF00625
Domain	GK/Ca_channel_bsu	CACNB2 DLG2 DLG3	1.97e-04	26	82	3	IPR008145
Domain	Guanylate_kin-like_dom	CACNB2 DLG2 DLG3	1.97e-04	26	82	3	IPR008144
Domain	GuKc	CACNB2 DLG2 DLG3	1.97e-04	26	82	3	SM00072
Domain	SH3	CACNB2 SRGAP1 DLG2 DLG3 SNX33 SPATA13	3.76e-04	216	82	6	SM00326
Domain	SH3	CACNB2 SRGAP1 DLG2 DLG3 SNX33 SPATA13	3.76e-04	216	82	6	PS50002
Domain	PDZ	SHROOM3 DLG2 DLG3 FRMPD3 RIMS2	3.91e-04	141	82	5	PF00595
Domain	SH3_domain	CACNB2 SRGAP1 DLG2 DLG3 SNX33 SPATA13	4.15e-04	220	82	6	IPR001452
Domain	PDZ	SHROOM3 DLG2 DLG3 FRMPD3 RIMS2	4.88e-04	148	82	5	SM00228
Domain	-	SHROOM3 DLG2 DLG3 FRMPD3 RIMS2	5.19e-04	150	82	5	2.30.42.10
Domain	PDZ	SHROOM3 DLG2 DLG3 FRMPD3 RIMS2	5.35e-04	151	82	5	PS50106
Domain	PDZ	SHROOM3 DLG2 DLG3 FRMPD3 RIMS2	5.51e-04	152	82	5	IPR001478
Domain	FAD-dep_OxRdtase	GPD2 DMGDH	1.22e-03	12	82	2	IPR006076
Domain	DAO	GPD2 DMGDH	1.22e-03	12	82	2	PF01266
Domain	Guanylate_kinase_CS	DLG2 DLG3	2.20e-03	16	82	2	IPR020590
Domain	Homeodomain-like	SATB1 POGZ RERE HOXB13 MEIS2 BSX	3.40e-03	332	82	6	IPR009057
Domain	-	TUBG2 TUBG1	3.44e-03	20	82	2	3.30.1330.20
Domain	-	TUBG2 TUBG1	3.79e-03	21	82	2	1.10.287.600
Domain	Tubulin_C	TUBG2 TUBG1	4.15e-03	22	82	2	SM00865
Domain	Tubulin_C	TUBG2 TUBG1	4.15e-03	22	82	2	PF03953
Domain	Tubulin/FtsZ_2-layer-sand-dom	TUBG2 TUBG1	4.15e-03	22	82	2	IPR018316
Domain	-	TUBG2 TUBG1	4.15e-03	22	82	2	3.40.50.1440
Domain	Tubulin_C	TUBG2 TUBG1	4.54e-03	23	82	2	IPR023123
Domain	TUBULIN	TUBG2 TUBG1	4.54e-03	23	82	2	PS00227
Domain	Tubulin	TUBG2 TUBG1	4.54e-03	23	82	2	IPR000217
Domain	Tub_FtsZ_C	TUBG2 TUBG1	4.54e-03	23	82	2	IPR008280
Domain	Tubulin	TUBG2 TUBG1	4.54e-03	23	82	2	SM00864
Domain	GUANYLATE_KINASE_2	DLG2 DLG3	4.54e-03	23	82	2	PS50052
Domain	GUANYLATE_KINASE_1	DLG2 DLG3	4.54e-03	23	82	2	PS00856
Domain	Tubulin_CS	TUBG2 TUBG1	4.54e-03	23	82	2	IPR017975
Domain	Kunitz_BPTI	METAP1 AUTS2	4.54e-03	23	82	2	IPR002223
Domain	Tubulin_FtsZ_GTPase	TUBG2 TUBG1	4.94e-03	24	82	2	IPR003008
Domain	Tubulin	TUBG2 TUBG1	4.94e-03	24	82	2	PF00091
Domain	TGFb_propeptide	TGFB3 GDF5	6.68e-03	28	82	2	PF00688
Domain	TGF-b_N	TGFB3 GDF5	6.68e-03	28	82	2	IPR001111
Domain	-	SATB1 POGZ HOXB13 MEIS2 BSX	8.15e-03	283	82	5	1.10.10.60
Domain	TGF-beta-rel	TGFB3 GDF5	8.67e-03	32	82	2	IPR015615
Domain	TGFb_CS	TGFB3 GDF5	8.67e-03	32	82	2	IPR017948
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNB2 SHROOM3 CAD ZBTB22 DLG2 DLG3 FRMPD3 PRRT1 WDR26 DYNC1H1 SPATA13 KHSRP FERMT3 EPHA4	7.45e-08	963	84	14	28671696
Pubmed	Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.	TUBG2 DYNC1H1 TUBG1	2.21e-06	11	84	3	29229923
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	CAD GTF3C1 WDR26 LIN9 MED12 DYNC1H1 KHSRP	4.49e-06	272	84	7	31010829
Pubmed	Differential expression of human γ-tubulin isotypes during neuronal development and oxidative stress points to a γ-tubulin-2 prosurvival function.	TUBG2 TUBG1	5.76e-06	2	84	2	28119396
Pubmed	p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1.	NOTCH1 TP73	5.76e-06	2	84	2	35617425
Pubmed	Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification.	CBFA2T3 NOTCH1	5.76e-06	2	84	2	20123979
Pubmed	MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages.	TUBG2 TUBG1	5.76e-06	2	84	2	17442887
Pubmed	Overexpression of γ-tubulin in non-small cell lung cancer.	TUBG2 TUBG1	5.76e-06	2	84	2	22806905
Pubmed	Gene knockout analysis of two gamma-tubulin isoforms in mice.	TUBG2 TUBG1	5.76e-06	2	84	2	15893303
Pubmed	Allocation of gamma-tubulin between oocyte cortex and meiotic spindle influences asymmetric cytokinesis in the mouse oocyte.	TUBG2 TUBG1	5.76e-06	2	84	2	17287496
Pubmed	Notch signaling promotes the generation of EphrinB1-positive intestinal epithelial cells.	EFNB1 NOTCH1	5.76e-06	2	84	2	19332065
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CADM3 NAA35 EFNB1 PTPRF PIAS3 CYB5R3 AUTS2 POGZ RERE ZFC3H1 MED12 RNF111 CPSF7	6.10e-06	1203	84	13	29180619
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	GTF3C1 SATB1 POGZ SNX33 CBFA2T3 FOXH1 LIN9 HOXB13 DYNC1H1 NOTCH1 KHSRP	6.90e-06	857	84	11	25609649
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	GTF3C1 SATB1 CYB5R3 POGZ RERE WDR26 LIN9 MED12	8.00e-06	418	84	8	34709266
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ERF GTF3C1 SATB1 PIAS3 ZBTB22 POGZ HOXB13 MEIS2 CREB3 RNF111	8.27e-06	709	84	10	22988430
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FRAS1 SHROOM3 PTPRF PIK3C2B ZNF341 MED12 HOXB13 DYNC1H1 TUBG1 NOTCH1 CREB3 SPATA13	1.37e-05	1105	84	12	35748872
Pubmed	A brain atlas of synapse protein lifetime across the mouse lifespan.	DLG2 DLG3	1.73e-05	3	84	2	36202095
Pubmed	The gamma-tubulin gene family in humans.	TUBG2 TUBG1	1.73e-05	3	84	2	10903841
Pubmed	MAGUKs are essential, but redundant, in long-term potentiation.	DLG2 DLG3	1.73e-05	3	84	2	34244435
Pubmed	Human TUBG2 gene is expressed as two splice variant mRNA and involved in cell growth.	TUBG2 TUBG1	1.73e-05	3	84	2	27015882
Pubmed	Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.	DLG2 DLG3	1.73e-05	3	84	2	23486974
Pubmed	Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin.	TUBG2 TUBG1	1.73e-05	3	84	2	9566969
Pubmed	Architecture of the Mouse Brain Synaptome.	DLG2 DLG3	1.73e-05	3	84	2	30078578
Pubmed	Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.	DLG2 DLG3	1.73e-05	3	84	2	17046693
Pubmed	A craniosynostosis massively parallel sequencing panel study in 309 Australian and New Zealand patients: findings and recommendations.	EFNB1 ERF	1.73e-05	3	84	2	29215649
Pubmed	The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.	TUBG2 TUBG1	1.73e-05	3	84	2	26021315
Pubmed	Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference.	DLG2 DLG3	1.73e-05	3	84	2	28077487
Pubmed	Generation of mice with functional inactivation of talpid3, a gene first identified in chicken.	GDF5 TUBG2 TUBG1	2.32e-05	23	84	3	21750036
Pubmed	PDK1 Regulates Transition Period of Apical Progenitors to Basal Progenitors by Controlling Asymmetric Cell Division.	TUBG2 TUBG1 NOTCH1	2.32e-05	23	84	3	31504280
Pubmed	Interaction network of human early embryonic transcription factors.	ERF SATB1 AUTS2 POGZ RERE LIN9 MED12	2.34e-05	351	84	7	38297188
Pubmed	Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development.	TUBG2 TUBG1 TP73	2.65e-05	24	84	3	35322202
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZSWIM8 CAD GTF3C1 ELP1 DLAT POGZ MED12 DYNC1H1 KHSRP	2.89e-05	653	84	9	22586326
Pubmed	Neural tube defects by NUAK1 and NUAK2 double mutation.	SHROOM3 TUBG2 TUBG1	3.01e-05	25	84	3	22689267
Pubmed	MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development.	TUBG2 TUBG1 NOTCH1	3.01e-05	25	84	3	27707753
Pubmed	Eph receptor interclass cooperation is required for the regulation of cell proliferation.	EFNB1 EPHA4	3.45e-05	4	84	2	27565439
Pubmed	Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1.	NOTCH1 TP73	3.45e-05	4	84	2	31712410
Pubmed	Loss of Necdin impairs myosin activation and delays cell polarization.	TUBG2 TUBG1	3.45e-05	4	84	2	20665884
Pubmed	Cilia organize ependymal planar polarity.	TUBG2 TUBG1	3.45e-05	4	84	2	20164345
Pubmed	Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.	TUBG2 TUBG1	3.45e-05	4	84	2	36574677
Pubmed	Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1.	EFNB1 EPHA4	3.45e-05	4	84	2	14576067
Pubmed	Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex.	DLG2 DLG3	3.45e-05	4	84	2	21031555
Pubmed	Synaptic scaffold evolution generated components of vertebrate cognitive complexity.	DLG2 DLG3	3.45e-05	4	84	2	23201973
Pubmed	Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells.	TUBG2 TUBG1	3.45e-05	4	84	2	16798874
Pubmed	Human transcription factor protein interaction networks.	CAD ERF GTF3C1 SATB1 CYB5R3 AUTS2 DLAT POGZ RERE LIN9 DYNC1H1 TAB3 CPSF7	3.73e-05	1429	84	13	35140242
Pubmed	Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis.	SHROOM3 TUBG2 TUBG1	4.26e-05	28	84	3	21880782
Pubmed	Primary cilia and Gli3 activity regulate cerebral cortical size.	TUBG2 TUBG1 NOTCH1	4.75e-05	29	84	3	21976438
Pubmed	Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium.	TUBG2 TUBG1	5.74e-05	5	84	2	21285373
Pubmed	Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.	TUBG2 TUBG1	5.74e-05	5	84	2	29244804
Pubmed	Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.	EFNB1 EPHA4	5.74e-05	5	84	2	12084815
Pubmed	Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95.	DLG2 DLG3	5.74e-05	5	84	2	11134026
Pubmed	Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia.	TUBG2 TUBG1	5.74e-05	5	84	2	31390572
Pubmed	EphB2 and EphA4 receptors regulate formation of the principal inter-hemispheric tracts of the mammalian forebrain.	EFNB1 EPHA4	5.74e-05	5	84	2	19289155
Pubmed	A two-kinesin mechanism controls neurogenesis in the developing brain.	TUBG2 TUBG1	5.74e-05	5	84	2	38040957
Pubmed	Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases.	TUBG2 TUBG1	5.74e-05	5	84	2	16751367
Pubmed	Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins.	DLG2 DLG3	5.74e-05	5	84	2	12713445
Pubmed	A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos.	TUBG2 TUBG1	5.74e-05	5	84	2	15680357
Pubmed	Analysis of Ellis van Creveld syndrome gene products: implications for cardiovascular development and disease.	TUBG2 TUBG1	5.74e-05	5	84	2	19251731
Pubmed	The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis.	TUBG2 TUBG1	5.74e-05	5	84	2	21529752
Pubmed	Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis.	TUBG2 TUBG1	5.74e-05	5	84	2	18729223
Pubmed	WDR62 is associated with the spindle pole and is mutated in human microcephaly.	TUBG2 TUBG1	5.74e-05	5	84	2	20890279
Pubmed	Speriolin is a novel human and mouse sperm centrosome protein.	TUBG2 TUBG1	5.74e-05	5	84	2	20542897
Pubmed	The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.	DLG2 DLG3	5.74e-05	5	84	2	10725395
Pubmed	Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies.	TUBG2 TUBG1	5.74e-05	5	84	2	25877302
Pubmed	HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.	TUBG2 TUBG1	5.74e-05	5	84	2	14767062
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	GPD2 CAD GTF3C1 CYB5R3 POGZ CBFA2T3 MED12 DYNC1H1 TUBG1 KHSRP CPSF7	5.86e-05	1082	84	11	38697112
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	METAP1 ZSWIM8 SATB1 PIAS3 TUBG2 DLAT DLG2 POGZ ZFC3H1 WDR26 DYNC1H1 RNF111	5.96e-05	1285	84	12	35914814
Pubmed	Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.	DLAT WDR26 CPSF7	6.41e-05	32	84	3	19542561
Pubmed	OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.	PIAS3 DLAT TAB3 CPSF7	7.21e-05	91	84	4	30472188
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	MGAM CAD DYNC1H1 TUBG1 KHSRP	8.21e-05	182	84	5	31067453
Pubmed	The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.	TUBG2 TUBG1 NOTCH1	8.41e-05	35	84	3	28402857
Pubmed	Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage.	TUBG2 TUBG1 TP73	8.41e-05	35	84	3	37890489
Pubmed	The CPLANE protein Fuzzy regulates ciliogenesis by suppressing actin polymerization at the base of the primary cilium via p190A RhoGAP.	TUBG2 TUBG1	8.59e-05	6	84	2	38546045
Pubmed	Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif.	DLG2 DLG3	8.59e-05	6	84	2	12070168
Pubmed	Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor.	TUBG2 TUBG1	8.59e-05	6	84	2	30970247
Pubmed	Expression Analyses of Cep152, a Responsible Gene Product for Autosomal Recessive Primary Microcephaly, during Mouse Brain Development.	TUBG2 TUBG1	8.59e-05	6	84	2	35259752
Pubmed	EphA4 is necessary for spatially selective peripheral somatosensory topography.	EFNB1 EPHA4	8.59e-05	6	84	2	20014408
Pubmed	Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.	DLG2 DLG3	8.59e-05	6	84	2	11572861
Pubmed	Cyclin C is a haploinsufficient tumour suppressor.	MED12 NOTCH1	8.59e-05	6	84	2	25344755
Pubmed	DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.	TUBG2 TUBG1	8.59e-05	6	84	2	22842144
Pubmed	Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins.	DLG2 DLG3	8.59e-05	6	84	2	11274188
Pubmed	Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.	TUBG2 TUBG1	8.59e-05	6	84	2	29229864
Pubmed	Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.	DLG2 DLG3	8.59e-05	6	84	2	19118189
Pubmed	Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton.	TUBG2 TUBG1	8.59e-05	6	84	2	10840040
Pubmed	CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors.	TUBG2 TUBG1	8.59e-05	6	84	2	36334595
Pubmed	Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis.	CACNB2 NOTCH1	8.59e-05	6	84	2	8756350
Pubmed	Ephrin-B1 forward and reverse signaling are required during mouse development.	EFNB1 EPHA4	8.59e-05	6	84	2	15037550
Pubmed	A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.	TUBG2 TUBG1	8.59e-05	6	84	2	11237715
Pubmed	Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.	PTPRF PIAS3 RNF111	1.08e-04	38	84	3	28680062
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	GTF3C1 PIAS3 ZFC3H1 WDR26 MED12 KHSRP CPSF7	1.16e-04	453	84	7	29656893
Pubmed	A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.	DLG2 DLG3	1.20e-04	7	84	2	9753324
Pubmed	HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis.	TUBG2 TUBG1	1.20e-04	7	84	2	29724823
Pubmed	Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein.	DYNC1H1 TUBG1	1.20e-04	7	84	2	14970193
Pubmed	Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway.	RIPK1 TAB3	1.20e-04	7	84	2	19955178
Pubmed	Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes lineage progression.	TUBG2 TUBG1	1.20e-04	7	84	2	22902295
Pubmed	Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.	DLG2 DLG3	1.20e-04	7	84	2	19243221
Pubmed	PCP auto count: a novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting.	TUBG2 TUBG1	1.20e-04	7	84	2	38827526
Pubmed	Mammalian RanBP1 regulates centrosome cohesion during mitosis.	TUBG2 TUBG1	1.20e-04	7	84	2	12840069
Pubmed	AIRE is a critical spindle-associated protein in embryonic stem cells.	TUBG2 TUBG1	1.20e-04	7	84	2	28742026
Pubmed	Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses.	DLG2 DLG3	1.20e-04	7	84	2	11997254
Pubmed	TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis.	TUBG2 TUBG1	1.20e-04	7	84	2	38261656
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	CACNB2 DLG2 DLG3	8.99e-05	26	61	3	904
GeneFamily	PDZ domain containing	SHROOM3 DLG2 DLG3 FRMPD3 RIMS2	1.60e-04	152	61	5	1220
Coexpression	GUO_HEX_TARGETS_UP	MAGEL2 ERF SATB1 WDR26 EPHA4	4.96e-06	78	83	5	M1436
Coexpression	GUO_HEX_TARGETS_UP	MAGEL2 ERF SATB1 WDR26 EPHA4	5.62e-06	80	83	5	MM626
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFNB1 PIK3C2B SRGAP1 CBFA2T3 NOTCH1 MEIS2	1.65e-06	193	83	6	d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Thalamus / BrainAtlas - Mouse McCarroll V32	MAGEL2 DACT2 DLG2 FRMPD3 MEIS2	8.50e-06	148	83	5	afebb64365c94b9476494bffe7c364677f19c8cf
ToppCell	Thalamus-Neuronal-Inhibitory\|Thalamus / BrainAtlas - Mouse McCarroll V32	MAGEL2 DACT2 DLG2 FRMPD3 MEIS2	8.50e-06	148	83	5	5f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGSF10 CACNB2 SHROOM3 TRPM3 DLG2	2.02e-05	177	83	5	b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 PIK3C2B CBFA2T3 MEIS2 EPHA4	2.19e-05	180	83	5	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF10 PIK3C2B CBFA2T3 MEIS2 EPHA4	2.19e-05	180	83	5	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SHROOM3 TRPM3 DLG2 RERE	2.98e-05	192	83	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B SRGAP1 CBFA2T3 NOTCH1 MEIS2	3.05e-05	193	83	5	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2B SRGAP1 CBFA2T3 NOTCH1 MEIS2	3.05e-05	193	83	5	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPD2 SATB1 PTPRF RERE DYNC1H1	3.21e-05	195	83	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPD2 SATB1 PTPRF RERE DYNC1H1	3.21e-05	195	83	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-PFC\|World / Primary Cells by Cluster	SRGAP1 AUTS2 RERE DYNC1H1 MEIS2	3.37e-05	197	83	5	2c3b0072f8e1e09c77a85c6fc3133d1796932fb2
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-PFC-29\|World / Primary Cells by Cluster	SRGAP1 AUTS2 RERE DYNC1H1 MEIS2	3.37e-05	197	83	5	c5bc0e7eb85642b270efc2ba92b13a736af22052
ToppCell	Transverse-T_cell-Tfh\|Transverse / Region, Cell class and subclass	SRGAP1 NANOS1 NOTCH1 SPATA13 KCNRG	3.53e-05	199	83	5	cbef8f95edf2e86e16c448a76068d7ed8f6b7748
ToppCell	Transverse-(1)_T_cell-(16)_Tfh\|Transverse / shred on region, Cell_type, and subtype	SRGAP1 NANOS1 NOTCH1 SPATA13 KCNRG	3.53e-05	199	83	5	aa31e26d48066f865ca33251a33a28934c0a7a44
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-B-Plasmablast\|Leuk-UTI / Disease, condition lineage and cell class	DMGDH RIPK1 PIK3C2B TUBG1 TAB3	3.53e-05	199	83	5	1b17e6d5e6b994dec65efae2667f4f1f438161b1
Disease	complex cortical dysplasia with other brain malformations 4 (implicated_via_orthology)	TUBG2 TUBG1	7.63e-06	2	82	2	DOID:0090138 (implicated_via_orthology)
Disease	muscular disease (is_implicated_in)	CPT2 TUBG1	1.14e-04	6	82	2	DOID:0080000 (is_implicated_in)
Disease	benign neoplasm (implicated_via_orthology)	DLG2 DLG3	2.11e-04	8	82	2	DOID:0060072 (implicated_via_orthology)
Disease	Familial thoracic aortic aneurysm and aortic dissection	TGFB3 MED12 NOTCH1	4.38e-04	53	82	3	C4707243
Disease	Small cell carcinoma of lung	RIMS2 TP73 KHSRP	4.63e-04	54	82	3	C0149925
Disease	behavior	NANOS1 MEIS2 SPATA13	4.89e-04	55	82	3	GO_0007610
Disease	Malformations of Cortical Development	DYNC1H1 TUBG1	6.79e-04	14	82	2	C1955869
Disease	Cortical Dysplasia	DYNC1H1 TUBG1	6.79e-04	14	82	2	C0431380
Disease	atopic eczema	NAA35 ADO SATB1 RERE RNF111	6.98e-04	252	82	5	EFO_0000274
Disease	1,3,7-trimethylurate measurement	FRAS1 PTPRF	7.82e-04	15	82	2	EFO_0021172
Disease	Trigonocephaly	EFNB1 ERF	8.93e-04	16	82	2	C0265535
Disease	Scaphycephaly	EFNB1 ERF	8.93e-04	16	82	2	C0265534
Disease	Synostotic Posterior Plagiocephaly	EFNB1 ERF	8.93e-04	16	82	2	C1833340
Disease	Synostotic Anterior Plagiocephaly	EFNB1 ERF	8.93e-04	16	82	2	C2931150
Disease	Metopic synostosis	EFNB1 ERF	8.93e-04	16	82	2	C1860819
Disease	Craniosynostosis, Type 1	EFNB1 ERF	8.93e-04	16	82	2	C4551902
Disease	Acrocephaly	EFNB1 ERF	8.93e-04	16	82	2	C0030044
Disease	cancer (implicated_via_orthology)	POLD2 DLG2 DLG3 NOTCH1 TP73	9.19e-04	268	82	5	DOID:162 (implicated_via_orthology)
Disease	Brachycephaly	EFNB1 ERF	1.01e-03	17	82	2	C0221356
Disease	Carcinoma of bladder	NOTCH1 EPHA4	1.13e-03	18	82	2	C0699885
Disease	Craniosynostosis	EFNB1 ERF	1.40e-03	20	82	2	C0010278
Disease	Moderate albuminuria	SHROOM3 GALP SPATA13	1.46e-03	80	82	3	HP_0012594
Disease	Arthrogryposis	MAGEL2 DYNC1H1	1.55e-03	21	82	2	C0003886
Disease	urinary albumin to creatinine ratio	MGAM SHROOM3 ADO AUTS2	1.58e-03	179	82	4	EFO_0007778
Disease	body weight	GDF5 MGAM CACNB2 TUBG2 ZNF341 AUTS2 DLG2 ITIH6 KCNRG EPHA4	2.57e-03	1261	82	10	EFO_0004338

Protein segments in the cluster

Peptide	Gene	Start	Entry
PALPMTPTHLAYTPS	ERF	266	P50548
QPLPPNLPPVTYMHI	ADO	76	Q96SZ5
YPLMPTPTLLAPHAH	BSX	56	Q3C1V8
YLLHVATTQPPPMPR	HTR3C	331	Q8WXA8
RPHISLVPSAYPLQM	ADAD1	451	Q96M93
YTPTAMIRPDPPHPR	CADM3	231	Q8N126
HTPPYDVVPSMRPVV	CACNB2	271	Q08289
PTMHYQDSLPRLPIP	CPT2	41	P23786
PPPMIQYACLPNLDH	CYB5R3	276	P00387
VLPYFNRPPSALPLM	CPSF7	221	Q8N684
ICRPLHYPTLMTPTL	OR6N1	126	Q8NGY5
VEPPPPAQLHFMYVA	NOTCH1	1726	P46531
YRPPPAAPHLQELMA	FRAS1	1541	Q86XX4
PFRPPPITPHEYMLS	GDF5	161	P43026
APHLSAPLPIMLPVY	GPD2	151	P43304
MTPPRLHYTPPLQSP	LIN9	296	Q5TKA1
KLRPHYPLMPTRPVP	METAP1	86	P53582
YPLMPTRPVPSYIQR	METAP1	91	P53582
PVYSRPTVLMRAPPA	MAGEL2	21	Q9UJ55
YCMDTSHQPLLPAPP	LYSMD4	191	Q5XG99
YLPIYTPNVVMPLAP	FOXH1	281	O75593
YPPNPKSRAPRMLVI	GPBP1	161	Q86WP2
TLLLPPPPLYTRHRM	MYG1	11	Q9HB07
PPPLYTRHRMLGPES	MYG1	16	Q9HB07
SYTPPQMTPHPTQLR	MEIS2	406	O14770
PTQLRHGPPMHSYLP	MEIS2	416	O14770
RYEVPVPLNIPSMPS	MGAM	1061	O43451
YRLPPPMDCPIALHQ	EPHA4	841	P54764
PTNYTLPQQPLHPCM	POLD2	301	P49005
APPPMALVPSARYVS	NANOS1	16	Q8WY41
PGSSYPPHMQVLLPA	DLAT	211	P10515
PVVHRGMPRYVPNSP	PCED1A	401	Q9H1Q7
TPGLPSMHYPRISPT	AUTS2	1186	Q8WXX7
VRLPMQKLPTRPTYP	MED12	1861	Q93074
PPMCTYQLLFPHPVN	ELP1	411	O95163
MTLLPLPPQRPSYHD	KCNRG	161	Q8N5I3
PCIFVYMRPPATLPI	OR4C13	251	Q8NGP0
PTPPPHYRLEDIAMA	CBFA2T3	336	O75081
RSKTMPPQVPPRTYA	PIK3C2B	276	O00750
PHPSPYMPRRQLHGE	RIMS2	941	Q9UQ26
HLQPPSYGPVLSPMN	TP73	401	O15350
PYSHPPQPSKRNVME	GALP	76	Q9UBC7
APYHQPPTRRLNPMA	ERVK-10	241	P87889
VMIVAYPPRITNRPP	IGSF10	2521	Q6WRI0
RSKPPATVHYTRPMP	IFT46	191	Q9NQC8
LYPMPVLVPLAVAPQ	DACT2	566	Q5SW24
LTSDVYPHPPLGMLP	FRMPD3	1441	Q5JV73
HPVYIVQEMPPQSPA	EFNB1	326	P98172
QVPPTRYSPIPRHML	DLG3	361	Q92796
PITYSPDILPMVGPH	DMGDH	371	Q9UI17
QVPKYPLHTRPRVPA	ITIH6	816	Q6UXX5
MPVVYDKLPQPPSHR	DYNC1H1	3126	Q14204
YMNITLPPPFQHPDL	GPR63	26	Q9BZJ6
PISPGRYSPIPKHML	DLG2	321	Q15700
HPAAPTLMPAVNYAP	HOXB13	36	Q92826
LLHYMPQAPSAEPPL	CREB3	311	O43889
PRRPPHDYMPIAVLT	PRRT1	216	Q99946
YQTPGMRDHPPIPIT	PTPRF	1321	P10586
PIHPPPRTSMTEEYR	KHSRP	136	Q92945
HRAEYMTTRPPNVPP	SRGAP1	471	Q7Z6B7
PPSYMHIPRYSTNPI	TAB3	181	Q8N5C8
SMDPLPVFLYPPVQR	POGZ	721	Q7Z3K3
YPSQHMAFRPKPPLE	SNX33	151	Q8WV41
QPLPPYTPAMMHRSN	SHROOM3	1376	Q8TF72
MPLNPTDPLLAYHMP	RERE	1276	Q9P2R6
PRVWYRPIPSHMPSL	RIPK1	486	Q13546
YLNHPPPVSRSMNKP	SATB1	346	Q01826
QPVHPDVTMKPLPFY	PIAS3	121	Q9Y6X2
SRPPMPAHQVPPYKA	SPATA13	51	Q96N96
LNMHSVPSYLTQPPP	ZNF341	166	Q9BYN7
APFNSVMTPPPVHYL	NAA35	621	Q5VZE5
MPPPYASLTRPLHHQ	RNF111	646	Q6ZNA4
IPTPRLHFLMTGYTP	TUBG1	261	P23258
PLRAAIPYMPFPVAV	STUM	41	Q69YW2
RPVLPPPLIIFSHMT	TRPM3	1166	Q9HCF6
TEACYHMLSRPQPPP	FERMT3	191	Q86UX7
PDYPIHPPRVKLMTT	UBE2Z	156	Q9H832
LRYVAPPSLRMPPTV	CAD	2101	P27708
SFPVPSMAPITVHPY	ZSWIM8	1576	A7E2V4
IPTPRLHFLMTGYTP	TUBG2	261	Q9NRH3
LQTYLPPSVMLPPRR	WDR26	286	Q9H7D7
MGITPLRNYHPIVVP	GTF3C1	771	Q12789
MEVKPCPFRPYHSPL	ZFC3H1	1136	O60293
PPEPTVMTHVPYQVL	TGFB3	56	P10600
LRRPTYTPPSIMPQK	ZBTB22	281	O15209
SCPAPYLIHILIPMP	TEX13B	266	Q9BXU2
CPHLLMLPQDPSYPT	ZNF683	216	Q8IZ20