Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	GABRE GABRR2 NPY1R GPR18 OR4S2 OR4C11 OR11H4 FFAR3 GPR42 TMEM63C OR2J3 OR2A5 TAAR6 MET OR51E1 IL22RA2 OR4C15 SPHK1 OR52H1 OR1E3 ROS1 OR2AE1	7.11e-07	1353	100	22	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	NPY1R GPR18 OR4S2 OR4C11 OR11H4 FFAR3 GPR42 OR2J3 OR2A5 TAAR6 OR51E1 OR4C15 SPHK1 OR52H1 OR1E3 OR2AE1	7.81e-06	884	100	16	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 OR51E1 OR4C15 OR52H1 OR1E3 OR2AE1	6.06e-05	431	100	10	GO:0004984
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	GABRE GABRR2 TMEM63C RHAG RYR2 KCNH3 SLC9A2 SLC46A3 SLC30A5 KCNJ12 KCNJ18 SLC39A5	4.04e-04	758	100	12	GO:0015318
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GABRE GABRR2 TMEM63C RYR2 KCNJ12 KCNJ18	4.23e-04	193	100	6	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	GABRE GABRR2 TMEM63C RYR2 KCNJ12 KCNJ18	4.72e-04	197	100	6	GO:0022834
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	GABRE SFXN4 GABRR2 TMEM63C RYR2 KCNH3 SLC9A2 SLC46A3 SLC30A5 KCNJ12 KCNJ18 SLC39A5	6.04e-04	793	100	12	GO:0015075
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	STEAP2 SLC9A2 SLC30A5 PPP3R1 KCNJ12 KCNJ18 SLC39A5	5.19e-06	142	98	7	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	STEAP2 SLC9A2 SLC30A5 PPP3R1 KCNJ12 KCNJ18 SLC39A5	5.19e-06	142	98	7	GO:0098659
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 TLR9 RYR2 OR51E1 OR4C15 OR52H1 OR1E3 OR2AE1	7.12e-06	524	98	12	GO:0009593
GeneOntologyBiologicalProcess	transition metal ion transport	STEAP2 RYR2 SLC46A3 SLC30A5 HEPHL1 SLC39A5	1.65e-05	113	98	6	GO:0000041
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	GABRE SFXN4 GABRR2 MYO5A TMEM63C TLR9 STEAP2 FASLG RYR2 KCNH3 SLC9A2 SLC46A3 SLC30A5 PPP3R1 KCNJ12 KCNJ18 SLC39A5	1.83e-05	1115	98	17	GO:0034220
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	GABRE GABRR2 MYO5A TLR9 STEAP2 FASLG RHAG RYR2 KCNH3 SLC9A2 SLC46A3 SLC30A5 PPP3R1 KCNJ12 KCNJ18 SLC39A5	2.28e-05	1017	98	16	GO:0098660
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	NPY1R GPR18 OR4S2 OR4C11 OR11H4 FFAR3 GPR42 OR2J3 OR2A5 TSHB TAAR6 MET OR51E1 OR4C15 GUCY2F SPHK1 OR52H1 OR1E3 OR2AE1	2.67e-05	1395	98	19	GO:0007186
GeneOntologyBiologicalProcess	detection of stimulus	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 TLR9 RYR2 OR51E1 OR4C15 GUCY2F OR52H1 OR1E3 OR2AE1	3.69e-05	722	98	13	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 OR51E1 OR4C15 OR52H1 OR1E3 OR2AE1	3.97e-05	432	98	10	GO:0050911
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	6.68e-05	3	98	2	GO:0002879
GeneOntologyBiologicalProcess	sensory perception of smell	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 OR51E1 OR4C15 OR52H1 OR1E3 OR2AE1	7.34e-05	465	98	10	GO:0007608
GeneOntologyBiologicalProcess	monoatomic ion transport	GABRE SFXN4 GABRR2 MYO5A TMEM63C TLR9 STEAP2 FASLG RYR2 KCNH3 SLC9A2 SLC46A3 SLC30A5 PPP3R1 KCNJ12 KCNJ18 HEPHL1 SLC39A5	7.45e-05	1374	98	18	GO:0006811
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 OR51E1 OR4C15 GUCY2F OR52H1 OR1E3 OR2AE1	1.00e-04	582	98	11	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 OR51E1 OR4C15 OR52H1 OR1E3 OR2AE1	1.04e-04	485	98	10	GO:0050907
GeneOntologyBiologicalProcess	copper ion transport	STEAP2 SLC46A3 HEPHL1	1.12e-04	20	98	3	GO:0006825
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	MYO5A TLR9 STEAP2 FASLG RHAG RYR2 KCNH3 SLC9A2 SLC46A3 SLC30A5 PPP3R1 KCNJ12 KCNJ18 SLC39A5	1.14e-04	922	98	14	GO:0098662
GeneOntologyBiologicalProcess	import across plasma membrane	STEAP2 SLC9A2 SLC30A5 PPP3R1 KCNJ12 KCNJ18 SLC39A5	1.14e-04	230	98	7	GO:0098739
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	1.33e-04	4	98	2	GO:0002877
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	MYO5A TMEM63C TLR9 STEAP2 FASLG RYR2 KCNH3 SLC9A2 SLC46A3 SLC30A5 PPP3R1 KCNJ12 KCNJ18 SLC39A5	1.43e-04	942	98	14	GO:0098655
GeneOntologyBiologicalProcess	acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	2.21e-04	5	98	2	GO:0002525
GeneOntologyBiologicalProcess	chemical homeostasis	TLCD3B NPY1R MYO5A STXBP5L FFAR3 GPR42 STEAP2 FASLG RHAG RYR2 MET SLC9A2 SLC30A5 HEPHL1 SLC39A5 NR1H4	2.54e-04	1249	98	16	GO:0048878
GeneOntologyBiologicalProcess	metal ion transport	MYO5A TLR9 STEAP2 FASLG RYR2 KCNH3 SLC9A2 SLC46A3 SLC30A5 PPP3R1 KCNJ12 KCNJ18 HEPHL1 SLC39A5	2.64e-04	1000	98	14	GO:0030001
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 OR51E1 OR4C15 OR52H1 OR1E3 OR2AE1	2.74e-04	547	98	10	GO:0007606
GeneOntologyBiologicalProcess	norepinephrine secretion	FFAR3 GPR42 NISCH	3.13e-04	28	98	3	GO:0048243
GeneOntologyBiologicalProcess	positive regulation of neuronal action potential	FFAR3 GPR42	3.31e-04	6	98	2	GO:1904457
GeneOntologyBiologicalProcess	monoatomic cation transport	MYO5A TMEM63C TLR9 STEAP2 FASLG RYR2 KCNH3 SLC9A2 SLC46A3 SLC30A5 PPP3R1 KCNJ12 KCNJ18 HEPHL1 SLC39A5	3.57e-04	1157	98	15	GO:0006812
GeneOntologyBiologicalProcess	sensory perception	GABRR2 NPY1R OR4S2 MYO5A OR4C11 OR11H4 OR2J3 OR2A5 OR51E1 OR4C15 GUCY2F OR52H1 OR1E3 OR2AE1	5.31e-04	1072	98	14	GO:0007600
GeneOntologyBiologicalProcess	catecholamine secretion	MYO5A FFAR3 GPR42 NISCH	5.48e-04	79	98	4	GO:0050432
Domain	7tm_1	NPY1R GPR18 OR4S2 OR4C11 OR11H4 FFAR3 GPR42 OR2J3 OR2A5 TAAR6 OR51E1 OR4C15 OR52H1 OR2AE1	1.02e-05	677	97	14	PF00001
Domain	G_PROTEIN_RECEP_F1_1	NPY1R GPR18 OR4S2 OR4C11 OR11H4 FFAR3 GPR42 OR2J3 OR2A5 TAAR6 OR51E1 OR4C15 OR52H1 OR2AE1	1.17e-05	685	97	14	PS00237
Domain	G_PROTEIN_RECEP_F1_2	NPY1R GPR18 OR4S2 OR4C11 OR11H4 FFAR3 GPR42 OR2J3 OR2A5 TAAR6 OR51E1 OR4C15 OR52H1 OR2AE1	1.29e-05	691	97	14	PS50262
Domain	GPCR_Rhodpsn	NPY1R GPR18 OR4S2 OR4C11 OR11H4 FFAR3 GPR42 OR2J3 OR2A5 TAAR6 OR51E1 OR4C15 OR52H1 OR2AE1	1.31e-05	692	97	14	IPR000276
Domain	K_chnl_inward-rec_Kir2.2	KCNJ12 KCNJ18	2.67e-05	2	97	2	IPR003272
Domain	GPCR_Rhodpsn_7TM	NPY1R GPR18 OR4S2 OR4C11 OR11H4 FFAR3 OR2J3 OR2A5 TAAR6 OR51E1 OR4C15 OR52H1 OR2AE1	4.23e-05	670	97	13	IPR017452
Domain	K_chnl_inward-rec_Kir_N	KCNJ12 KCNJ18	7.98e-05	3	97	2	IPR013673
Domain	IRK_N	KCNJ12 KCNJ18	7.98e-05	3	97	2	PF08466
Domain	GPR40-rel_orph	FFAR3 GPR42	1.59e-04	4	97	2	IPR013312
Domain	Olfact_rcpt	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 OR51E1 OR4C15 OR52H1 OR2AE1	2.06e-04	393	97	9	IPR000725
Domain	HNOB_dom_associated	GUCY1A2 GUCY2F	3.95e-04	6	97	2	IPR011645
Domain	HNOBA	GUCY1A2 GUCY2F	3.95e-04	6	97	2	PF07701
Domain	Leu-rich_rpt	LRRC3C NLRX1 FBXL14 TLR9 IGSF10 LRRC3B NISCH	5.30e-04	271	97	7	IPR001611
Domain	-	LRRC3C NLRX1 FBXL14 TLR9 IGSF10 LRRC3B NISCH	1.42e-03	321	97	7	3.80.10.10
Domain	UBA	USP24 MARK2 NBR1	1.54e-03	44	97	3	IPR015940
Domain	L_dom-like	LRRC3C NLRX1 FBXL14 TLR9 IGSF10 LRRC3B NISCH	1.61e-03	328	97	7	IPR032675
Domain	UBA	USP24 MARK2 NBR1	1.87e-03	47	97	3	PS50030
Domain	LRR_6	NLRX1 FBXL14 TLR9	2.93e-03	55	97	3	PF13516
Domain	K_chnl_inward-rec_Kir_cyto	KCNJ12 KCNJ18	3.06e-03	16	97	2	IPR013518
Domain	IRK	KCNJ12 KCNJ18	3.06e-03	16	97	2	PF01007
Domain	-	KCNJ12 KCNJ18	3.06e-03	16	97	2	2.60.40.1400
Domain	K_chnl_inward-rec_Kir	KCNJ12 KCNJ18	3.06e-03	16	97	2	IPR016449
Domain	A/G_cyclase_CS	GUCY1A2 GUCY2F	3.45e-03	17	97	2	IPR018297
Domain	Nucleotide_cyclase	GUCY1A2 GUCY2F	3.87e-03	18	97	2	IPR029787
Domain	-	GUCY1A2 GUCY2F	3.87e-03	18	97	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	GUCY1A2 GUCY2F	4.31e-03	19	97	2	PS00452
Domain	Guanylate_cyc	GUCY1A2 GUCY2F	4.31e-03	19	97	2	PF00211
Domain	GUANYLATE_CYCLASE_2	GUCY1A2 GUCY2F	4.31e-03	19	97	2	PS50125
Domain	A/G_cyclase	GUCY1A2 GUCY2F	4.31e-03	19	97	2	IPR001054
Domain	CYCc	GUCY1A2 GUCY2F	4.31e-03	19	97	2	SM00044
Domain	-	ELAC2 INTS9	4.77e-03	20	97	2	3.60.15.10
Domain	Metallo-B-lactamas	ELAC2 INTS9	4.77e-03	20	97	2	IPR001279
Domain	LRR_1	LRRC3C FBXL14 TLR9 LRRC3B NISCH	5.70e-03	219	97	5	PF00560
Domain	Cupredoxin	PADI6 HEPHL1	5.76e-03	22	97	2	IPR008972
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 OR51E1 OR4C15 OR52H1 OR1E3	6.96e-07	340	101	9	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 OR51E1 OR4C15 OR52H1 OR1E3	6.96e-07	340	101	9	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 OR51E1 OR4C15 OR52H1 OR1E3	7.48e-07	343	101	9	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR4S2 OR4C11 OR11H4 OR2J3 OR2A5 OR51E1 OR4C15 OR52H1 OR1E3	8.04e-07	346	101	9	14611657
Pubmed	Fas ligand enhances malignant behavior of tumor cells through interaction with Met, hepatocyte growth factor receptor, in lipid rafts.	FASLG MET	8.35e-06	2	101	2	22535954
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	8.35e-06	2	101	2	25637492
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	8.35e-06	2	101	2	30478340
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	8.35e-06	2	101	2	35858247
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	8.35e-06	2	101	2	22506074
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	8.35e-06	2	101	2	24748202
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	8.35e-06	2	101	2	36362376
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	8.35e-06	2	101	2	20399779
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	8.35e-06	2	101	2	23110765
Pubmed	Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse.	KCNJ12 KCNJ18	8.35e-06	2	101	2	15705530
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	8.35e-06	2	101	2	26522986
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	8.35e-06	2	101	2	27664183
Pubmed	Crizotinib in c-MET- or ROS1-positive NSCLC: results of the AcSé phase II trial.	MET ROS1	8.35e-06	2	101	2	31584608
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	8.35e-06	2	101	2	37019194
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	8.35e-06	2	101	2	38040866
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	8.35e-06	2	101	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	8.35e-06	2	101	2	26091414
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	8.35e-06	2	101	2	27550964
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	8.35e-06	2	101	2	32073900
Pubmed	The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation.	TLR9 NR1H4	8.35e-06	2	101	2	23372731
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	8.35e-06	2	101	2	19630535
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	8.35e-06	2	101	2	14722361
Pubmed	ROS-1 re-arrangements and c-MET amplifications in adenocarcinoma lung: A tertiary care center study from North India.	MET ROS1	8.35e-06	2	101	2	31361233
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	8.35e-06	2	101	2	26260360
Pubmed	Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain.	EIF2S3B EIF2S3	8.35e-06	2	101	2	16325480
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42	2.50e-05	3	101	2	12496283
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42	2.50e-05	3	101	2	23665276
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42	2.50e-05	3	101	2	34210970
Pubmed	FISH patterns of ROS1, MET, and ALK with a correlation of ALK immunohistochemistry in lung cancer: a case for introducing ALK immunohistochemistry 'Equivocal' interpretation category in the Ventana anti-ALK (D5F3) CDx assay - A tertiary cancer center experience.	MET ROS1	2.50e-05	3	101	2	33402590
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42	2.50e-05	3	101	2	31719611
Pubmed	Analysis of the status of EGFR, ROS1 and MET genes in non-small cell lung adenocarcinoma.	MET ROS1	2.50e-05	3	101	2	28952227
Pubmed	Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation.	KCNJ12 KCNJ18	2.50e-05	3	101	2	10904001
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42	2.50e-05	3	101	2	25581519
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42	2.50e-05	3	101	2	31272808
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42	2.50e-05	3	101	2	38524121
Pubmed	Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.	FFAR3 GPR42	2.50e-05	3	101	2	22673524
Pubmed	Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels.	KCNJ12 KCNJ18	2.50e-05	3	101	2	17640933
Pubmed	Expression levels of ROS1/ALK/c-MET and therapeutic efficacy of cetuximab plus chemotherapy in advanced biliary tract cancer.	MET ROS1	2.50e-05	3	101	2	27136744
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42	2.50e-05	3	101	2	16123168
Pubmed	GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.	FFAR3 GPR42	2.50e-05	3	101	2	22493486
Pubmed	Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.	KCNJ12 KCNJ18	2.50e-05	3	101	2	8083233
Pubmed	Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain.	KLHL2 NPY1R	2.50e-05	3	101	2	10397770
Pubmed	The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes.	KCNJ12 KCNJ18	2.50e-05	3	101	2	11410627
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42	2.50e-05	3	101	2	23066016
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42	2.50e-05	3	101	2	22190648
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42	2.50e-05	3	101	2	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42	2.50e-05	3	101	2	29768180
Pubmed	Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.	FFAR3 GPR42	2.50e-05	3	101	2	18931303
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	FFAR3 GPR42	2.50e-05	3	101	2	38329121
Pubmed	CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.	TLCD3B BAZ1B MET	3.04e-05	21	101	3	22154806
Pubmed	Assignment of the murine inward rectifier potassium channel Irk2 (Kir2.2) gene to the central region of mouse chromosome 11.	KCNJ12 KCNJ18	4.99e-05	4	101	2	8921409
Pubmed	mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism.	RICTOR MET	4.99e-05	4	101	2	28475179
Pubmed	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.	FFAR3 GPR42	4.99e-05	4	101	2	23401498
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	FFAR3 GPR42	4.99e-05	4	101	2	9344866
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	FFAR3 GPR42	4.99e-05	4	101	2	21518883
Pubmed	Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.	EIF2S3B EIF2S3	4.99e-05	4	101	2	31836389
Pubmed	A family of fatty acid binding receptors.	FFAR3 GPR42	4.99e-05	4	101	2	15684720
Pubmed	Location of the gene for theta antigen in the mouse. II. Three-point crosses place Thy-1 in proximal region of chromosome 9.	MYO5A HEPHL1	4.99e-05	4	101	2	310441
Pubmed	Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma.	ITGA3 MET	4.99e-05	4	101	2	20927591
Pubmed	Genetic mapping of the polycystic kidney gene, pcy, on mouse chromosome 9.	GALK1 MYO5A	4.99e-05	4	101	2	8825940
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	FFAR3 GPR42	4.99e-05	4	101	2	29644622
Pubmed	Functional characterization of inward rectifier potassium ion channel in murine fetal ventricular cardiomyocytes.	KCNJ12 KCNJ18	4.99e-05	4	101	2	20798526
Pubmed	A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.	KCNJ12 KCNJ18	4.99e-05	4	101	2	32990585
Pubmed	Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.	GCH1 RYR2	4.99e-05	4	101	2	22798524
Pubmed	Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.	TLR9 FASLG	4.99e-05	4	101	2	29889098
Pubmed	Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.	FFAR3 GPR42	4.99e-05	4	101	2	29021375
Pubmed	Genetic interaction mapping in mammalian cells using CRISPR interference.	MED14 THOC2 TRRAP INTS9	5.01e-05	69	101	4	28481362
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	MED14 BAZ1B TRRAP MCM3AP INTS9 NUP188 IPO11	6.40e-05	341	101	7	32971831
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR4C11 OR11H4 OR4C15 OR1E3	6.59e-05	74	101	4	15081110
Pubmed	Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis.	ITGA3 MET	8.30e-05	5	101	2	19176588
Pubmed	Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.	KCNJ12 KCNJ18	8.30e-05	5	101	2	16177047
Pubmed	Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.	FFAR3 GPR42	8.30e-05	5	101	2	24327954
Pubmed	Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.	FFAR3 GPR42	8.30e-05	5	101	2	19047060
Pubmed	RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.	TLR9 FASLG	8.30e-05	5	101	2	16260486
Pubmed	Fatty acid binding receptors and their physiological role in type 2 diabetes.	FFAR3 GPR42	8.30e-05	5	101	2	19009545
Pubmed	Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease.	ITGA3 MET	1.24e-04	6	101	2	20852388
Pubmed	Genetic analysis of autoimmune type 1 diabetes mellitus in mice.	MPO TSHB	1.24e-04	6	101	2	1675432
Pubmed	Genetic mapping refines DFNB3 to 17p11.2, suggests multiple alleles of DFNB3, and supports homology to the mouse model shaker-2.	KCNJ12 KCNJ18	1.24e-04	6	101	2	9529344
Pubmed	The inward rectifier potassium channel family.	KCNJ12 KCNJ18	1.24e-04	6	101	2	7580148
Pubmed	New Targets in Non-Small Cell Lung Cancer.	MET ROS1	1.24e-04	6	101	2	27912827
Pubmed	Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.	FFAR3 GPR42	1.24e-04	6	101	2	19460454
Pubmed	Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration.	ITGA3 MET	1.24e-04	6	101	2	14602071
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	EIF2S3B TLR9 GLG1 TGFBRAP1 EIF2S3 NR1H4	1.63e-04	277	101	6	30745168
Pubmed	Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development.	EIF2S3B EIF2S3	1.74e-04	7	101	2	15669143
Pubmed	The human olfactory receptor gene family.	OR4S2 OR4C11 OR11H4 OR2J3 OR51E1 OR4C15 OR52H1 OR1E3	1.86e-04	541	101	8	14983052
Pubmed	Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.	FFAR3 GPR42	2.31e-04	8	101	2	34626852
Pubmed	Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS.	KCNJ12 KCNJ18	2.31e-04	8	101	2	27930290
Pubmed	Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide.	RICTOR TLR9	2.31e-04	8	101	2	24740015
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	SFXN4 RICTOR TRRAP MCM3AP	2.47e-04	104	101	4	31240132
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	NLRX1 ITGA3 STEAP2 MET SLC30A5 EIF2S3 MCM3AP NUP188 MARK2 NBR1 IPO11	2.63e-04	1061	101	11	33845483
Pubmed	Wnt pathway anomalies in developing amygdalae of Turner syndrome-like mice.	EIF2S3B EIF2S3	2.97e-04	9	101	2	17873295
Pubmed	Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution.	EIF2S3B EIF2S3	2.97e-04	9	101	2	9736774
Pubmed	Effect of tumour necrosis factor-alpha receptor 1 genetic deletion on carrageenan-induced acute inflammation: a comparison with etanercept.	MPO FASLG	2.97e-04	9	101	2	18505433
Pubmed	Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23.	MET ROS1	2.97e-04	9	101	2	1611909
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	MPO SEH1L MED14 BAZ1B EIF2S3B TRRAP SLC9A2 EIF2S3 ROS1	3.57e-04	754	101	9	35906200
Pubmed	A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.	KCNJ12 KCNJ18	3.70e-04	10	101	2	14960569
Cytoband	Ensembl 112 genes in cytogenetic band chr11q11	OR4S2 OR4C11 OR4C15	9.62e-05	40	101	3	chr11q11
Cytoband	11q11	OR4S2 OR4C11 OR4C15	1.56e-04	47	101	3	11q11
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Trf.Ctps_(Ctps)\|Striatum / BrainAtlas - Mouse McCarroll V32	GABRR2 A3GALT2 TSHB B3GNT6 MET	9.23e-07	79	99	5	239d34f40c3a96186231f3aabd41c4988af3f372
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf\|Striatum / BrainAtlas - Mouse McCarroll V32	GABRR2 A3GALT2 TSHB B3GNT6 MET	9.23e-07	79	99	5	a60fcbb278ba629af922c53faf58e4d96c537b15
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KLHL2 STXBP5L DENND3 RYR2 KCNH3 GUCY1A2	3.75e-06	186	99	6	84ba666237c18189d7e7556bd92dd953af733c00
Disease	MEHMO syndrome (implicated_via_orthology)	EIF2S3B EIF2S3	1.05e-05	2	96	2	DOID:0060801 (implicated_via_orthology)
Disease	hypopituitarism (implicated_via_orthology)	EIF2S3B EIF2S3	1.56e-04	6	96	2	DOID:9406 (implicated_via_orthology)
Disease	leukodystrophy (implicated_via_orthology)	EIF2S3B EIF2S3	3.72e-04	9	96	2	DOID:10579 (implicated_via_orthology)
Disease	asthma	LRRC3C IKZF3 GALK1 ADAM19 ZKSCAN2 FASLG SLC9A2 LRRC3B TGFBRAP1	7.71e-04	751	96	9	MONDO_0004979
Disease	cholangiocarcinoma (biomarker_via_orthology)	MET NR1H4	7.98e-04	13	96	2	DOID:4947 (biomarker_via_orthology)
Disease	high grade glioma (biomarker_via_orthology)	MET SPHK1	1.07e-03	15	96	2	DOID:3070 (biomarker_via_orthology)
Disease	third ventricle volume measurement	GABRR2 GUCY1A2	1.07e-03	15	96	2	EFO_0010335
Disease	lupus nephritis (is_implicated_in)	MPO TLR9	1.55e-03	18	96	2	DOID:0080162 (is_implicated_in)
Disease	Non-Small Cell Lung Carcinoma	FASLG MET ERGIC3 ROS1	1.71e-03	156	96	4	C0007131
Disease	Lung Neoplasms	MPO RICTOR FASLG MET ERGIC3	1.77e-03	265	96	5	C0024121
Disease	Malignant neoplasm of lung	MPO RICTOR FASLG MET ERGIC3	1.80e-03	266	96	5	C0242379
Disease	cardiovascular system disease (is_implicated_in)	MPO TLR9	2.11e-03	21	96	2	DOID:1287 (is_implicated_in)
Disease	hepatocellular carcinoma (is_implicated_in)	MPO TLR9 MET NR1H4	2.93e-03	181	96	4	DOID:684 (is_implicated_in)
Disease	interstitial lung disease (is_marker_for)	MPO TLR9	2.99e-03	25	96	2	DOID:3082 (is_marker_for)
Disease	primary biliary cholangitis (is_marker_for)	TLR9 NR1H4	2.99e-03	25	96	2	DOID:12236 (is_marker_for)
Disease	hepatocellular carcinoma (is_marker_for)	RICTOR TLR9 FASLG MET NR1H4	3.07e-03	301	96	5	DOID:684 (is_marker_for)
Disease	neutrophil-to-lymphocyte ratio	MPO LRRC3C IKZF3 AK9	3.17e-03	185	96	4	EFO_0008447

Protein segments in the cluster

Peptide	Gene	Start	Entry
MCAASASPDNLVFHM	CCDC148	1	Q8NFR7
FHGTTIGLAPLMAMC	ADAM19	306	Q9H013
TFSRMHVLLGMLDAC	BAZ1B	1161	Q9UIG0
FCGNDGFMHMTLASL	ALDH3B1	386	P43353
MPFHICFAFLMLGTG	GPR18	246	Q14330
EFSHIMAMTDPAFGS	FBXO4	306	Q9UKT5
HPEGSSYPFEVMCDM	ANGPTL5	171	Q86XS5
MGNEASYPLEMCSHF	PPP3R1	1	P63098
DFVMAPTSFLMGCHL	DENND3	256	A2RUS2
HFVSMLSEAMCFLAP	DENND3	536	A2RUS2
CMMALPYITEHTGFT	INTS9	106	Q9NV88
PHCSCTPSGFFMEMM	NR1H4	16	Q96RI1
FSICTMLIGALMHAV	KCNH3	481	Q9ULD8
LCQFMAMLPTAGHLL	LRRC3C	16	A6NJW4
LMTGHVDEFMCFIPT	PADI6	476	Q6TGC4
HFLCDMDPLMALSCA	OR11H4	186	Q8NGC9
ISFEGCMMQLFAEHF	OR4C15	91	Q8NGM1
DASITMCPSCFQMFH	IFT122	1201	Q9HBG6
TPCVMQVHGFMAAFL	KCNJ12	121	Q14500
MFCMAGLCLISFLHF	MGAT3	11	Q09327
PETGTYKDCMLMSHL	IPO11	886	Q9UI26
IHCAHFMCEEPMSSF	MCM3AP	756	O60318
MFMAHHCLGFAPRNS	TMEM63C	201	Q9P1W3
SAVFHGFFSMPEMRC	ITGA3	536	P26006
SLHEPMYIFLCMLSG	OR51E1	56	Q8TCB6
HFTGMAGDAMPTFCI	OIT3	61	Q8WWZ8
HIAMVVIFFGPCTFM	OR4S2	241	Q8NH73
MGVPFFSSLRCMVDL	MPO	1	P05164
MFLVTFDFSDMPAAH	FAM214B	441	Q7L5A3
FDFSDMPAAHMTFLR	FAM214B	446	Q7L5A3
FPHMPCAYLSIDAMD	ERGIC3	76	Q9Y282
SFAGMPCGIMDQFIS	GALK1	176	P51570
IDAGCSLHMLRFPMD	GABRE	191	P78334
MMPKHCFLGFLISFF	IL22RA2	1	Q969J5
FVLMILCFHSASMCP	LRRC3B	21	Q96PB8
ELFPMFMGGLLSAHN	NLRX1	621	Q86UT6
MTQVFALHLFGCMEI	OR4C11	96	Q6IEV9
METHISCLFPELLAM	FBXL14	1	Q8N1E6
LFLPFRMVEAANGMH	GPR42	66	O15529
LHCLPTLMNMAASFD	RICTOR	446	Q6R327
LAHFVAMCDTNMPFV	MED14	641	O60244
PCTMQTFLYMAFAHT	OR2A5	96	Q96R48
SLIHMAILMHFPFCG	OR2AE1	156	Q8NHA4
IMCLPFTFVYTLMDH	NPY1R	91	P25929
GDPMILSCLMEHLYT	GLG1	521	Q92896
SSGMLALHEEFMVPA	IGSF10	796	Q6WRI0
IAFSIENSHMCMSPL	BORA	466	Q6PGQ7
HGGIDPAFAMMVCLT	GUCY2F	461	P51841
LFLPFRMVEAANGMH	FFAR3	66	O14843
GLPGREAHFMFCMDV	A3GALT2	186	U3KPV4
FRVFCATMPHLSRGM	HEPHL1	696	Q6MZM0
YMLLCMHGTPGHEDF	MARK2	731	Q7KZI7
SFVDCPGHDILMATM	EIF2S3B	131	Q2VIR3
MFTIHMGCHGFRDPF	IKZF3	466	Q9UKT9
HTPLFPIDDAYMGMC	B3GNT6	301	Q6ZMB0
FAPKHMGLMLATCSA	SEH1L	121	Q96EE3
MSAGFCPDHKAAMVL	RYR2	2456	Q92736
AMCNMDFSHFPLDSQ	GABRR2	176	P28476
HMPMYLCLSNLSFSD	OR1E3	56	Q8WZA6
RFPSCAMHRFIQMGS	PANK1	311	Q8TE04
AHLMAVSLFFIPAMC	OR2J3	246	O76001
HSLHEPMFFFLSMLA	OR52H1	61	Q8NGJ2
AFPFHLMFDPSMSVL	GUCY1A2	326	P33402
FCSINSGLHSYMEMP	MET	281	P08581
SGLHSYMEMPLECIL	MET	286	P08581
TPCVMQVHGFMAAFL	KCNJ18	121	B7U540
MEFGVFPMEATHSSI	AK9	481	Q5TCS8
CTVLAMGLMVPFSFS	SFXN4	291	Q6P4A7
CADFLVGVTVMPFSM	TAAR6	76	Q96RI8
QTAALMAHLFEMGFC	NBR1	916	Q14596
DMFSMCEHHLVPFVG	GCH1	136	P30793
CMEDIHMAFIGIFTT	SLC46A3	321	Q7Z3Q1
PFAIMLFGMVTKFCS	STRIP1	261	Q5VSL9
FFAMVHVAYSLCLPM	STEAP2	311	Q8NFT2
CFCANGHIMIMSLPS	STXBP5L	996	Q9Y2K9
MMGSPVSHLLAGFCV	SLC39A5	1	Q6ZMH5
ISFMPTLHCVMHNGA	ZCCHC2	716	Q9C0B9
LCPFLMGAMRDSIHA	TGFBRAP1	766	Q8WUH2
RVMDADGLLEMFHCP	ZNF653	456	Q96CK0
MSMCEPQTLCHILGF	THOC2	236	Q8NI27
CISYHAPEALLTEMM	VPS35L	401	Q7Z3J2
AFDHMKVCFGDFPTM	ELAC2	746	Q9BQ52
EMFHLSGIMAITACA	SLC9A2	326	Q9UBY0
MHFPCHMTIEPSTFL	TLR9	106	Q9NR96
ESIFPGFASQHMLMR	EZH1	86	Q92800
MAMLCSPILYGSHTS	NISCH	816	Q9Y2I1
MDCLMLTFGDIPHHA	NUP188	306	Q5SRE5
CADMAIHPFGSMIIG	RHAG	286	Q02094
MSFQLEGMSPRCFIA	ROS1	1111	P08922
NHSTGLCLLVMFFMV	FASLG	76	P48023
GQAMSFCIPTEYTMH	TSHB	16	P01222
EQHMTTLLCMGFSDP	USP24	6	Q9UPU5
HMLFDCSALVMGLFA	SLC30A5	451	Q8TAD4
DFFLGCMLMAEVSTP	TLCD3B	156	Q71RH2
HMLEPCAFFEDMDAL	ZKSCAN2	411	Q63HK3
SHLGSEMFAAPMGRC	SPHK1	266	Q9NYA1
MMNCRFHVSGKPFTF	ZNF530	156	Q6P9A1
HSCPMLFATAEAMEA	ZNF142	321	P52746
CHFVSVGFHMAKPDM	ZNF382	41	Q96SR6
CPHGGLMFTFASMTK	USP48	776	Q86UV5
VLEHFAGVFTMMNPL	TRRAP	631	Q9Y4A5
MFTVDAMEKACLPGH	USP17L23	166	D6RBM5
SFVDCPGHDILMATM	EIF2S3	131	P41091
ACSPYFHAMFTGEMS	KLHL2	76	O95198
FHSVMCQHGMDPELI	MYO5A	1671	Q9Y4I1